Probe Set ID Gene Symbol Gene Title 1891 APR1 Vacuolar aspartic proteinase; mRNA abundance is equivalent in yeast-form and mycelial cells but is elevated at lower growth temperatures; upregulated in the presence of human neutrophils; detected by mass spec in stationary phase cultures 3680 SEP7 Septin, required for wild-type invasive growth in vitro but not required for virulence in a mouse model of systemic infection; localizes to hyphal septum or bud neck; Asn-rich; aberrant gel mobility 7436 AAF1 Possible regulatory protein; Glu-rich domain; production in S. cerevisiae increases endothelial cell adherence and flocculence; expressed under diverse conditions, detected in yeast-form and hyphal cells; alkaline or caspofungin upregulated 2251 AAH1 Protein not essential for viability; similar to S. cerevisiae Aah1p, which is an adenine deaminase involved in purine salvage and nitrogen catabolism; shows colony morphology-related gene regulation by Ssn6p; Hog1p-, biofilm-, CO2-induced 2810 AAP1 Putative amino acid permease; fungal-specific (no human or murine homolog) 3554 AAT1 Protein described as aspartate aminotransferase; soluble protein in hyphae; macrophage-induced protein; alkaline upregulated; amphotericin B repressed; gene used for strain identification by multilocus sequence typing, farnesol-induced 6287 AAT21 Predicted ORF in Assemblies 19, 20 and 21; Gcn4p-regulated; protein detected by mass spec in exponential and stationary phase cultures 4669 AAT22 Protein not essential for viability; similar to S. cerevisiae Aat2p, which is an aspartate aminotransferase involved in nitrogen metabolism; clade-associated gene expression; protein level decreased in stationary phase cultures 3331 ABC1 Protein described as ubiquinol-cytochrome-c reductase; induced upon adherence to polystyrene 6716 ABD1 RNA (guanine-N7-)-methyltransferase, SAM-dependent; methylates mRNA 5' cap; binds phosphorylated RNA Pol II C-terminal domain peptide; does not bind mRNA TPase and mRNA GTase (Cet1p and Cgt1p); functional homolog of S. cerevisiae Abd1p 1597 ABG1 Vacuolar membrane protein; depletion causes abnormal vacuolar morphology, cell separation defect, sensitivity to cell wall perturbation, and increased hyphal branching; essential gene with no mammalian homolog; Cyr1p-regulated 2699 ABP1 Protein similar to S. cerevisiae Abp1p, which is an actin-binding protein of the cortical actin cytoskeleton; caspofungin induced; protein detected by mass spec in stationary phase cultures 3676 ABP140 Protein similar to S. cerevisiae actin-binding protein Abp140p; induced upon biofilm formation 3529 ABP2 Protein of unknown function; induced in response to alpha pheromone in SpiderM medium 1291 ABZ1 Protein not essential for viability; similar to S. cerevisiae Abz1p, which is para-aminobenzoate (PABA) synthase; reports differ on whether a murine homolog exists 7043.1 ACB1 Protein described as similar to a region of acyl-coenzyme-A-binding protein; amphotericin B repressed; regulated by Nrg1p, Tup1p 7466 ACC1 Protein with similarity to acetyl-coenzyme-A carboxylases; regulated by Efg1p; amphotericin B repressed; caspofungin repressed; intron in 5'-UTR 6124 ACE2 Putative transcription factor involved in regulation of morphogenesis; required for wild-type cell separation, adherence, biofilm formation, and virulence in mouse; mutant is hyperfilamentous; similar to S. cerevisiae Ace2p and Swi5p 3417 ACF2 Putative endo-1,3-beta-glucanase; fungal-specific (no human or murine homolog) 3171 ACH1 Acetyl-coA hydrolase; acetate utilization; nonessential; soluble protein in hyphae; antigenic in human; induced on polystyrene adherence; farnesol-, ketoconazole-induced; no human or murine homolog 6385 ACO1 Protein described as aconitase; Gcn4p-regulated; amino acid starvation (3-AT treatment), amphotericin B, phagocytosis, farnesol induced; fluconazole-downregulated; expression greater in high iron; antigenic in human or murine infection 6632 ACO2 Protein described as aconitate hydratase 2; regulated by Gcn4p; repressed in response to amino acid starvation (3-aminotriazole treatment); transcriptionally regulated by iron; expression greater in high iron 1743 ACS1 Putative acetyl-CoA synthetase, similar to S. cerevisiae Acs1p; upregulated in the presence of human neutrophils; fluconazole-downregulated; regulated by Nrg1p and Mig1p; shows colony morphology-related gene regulation by Ssn6p 1064 ACS2 Probable acetyl-CoA synthetase, similar to known fungal acetyl-CoA synthetases; antigenic during murine systemic infection; antigenic in human; upregulated by Efg1p; macrophage-induced protein; soluble protein in hyphae 5007 ACT1 Actin; gene has intron; transcriptionally regulated by growth phase and by starvation; localizes to polarized growth site in budding and hyphal cells; required for wild-type Cdc42p localization; unprocessed N terminus 2331 ADA2 Putative transcriptional coactivator; cell wall integrity role; required for wild-type transcriptional response to caspofungin; mutant is caspofungin hypersensitive; role in regulation with Cas5p; zinc finger DNA-binding motif 868 ADAEC Transcription is specific to white cell type 7484 ADE1 Phosphoribosylaminoimadazole succinocarboxamide synthetase, enzyme of adenine biosynthesis; not induced during GCN response, in contrast to the S. cerevisiae ortholog; fungal-specific (no human or murine homolog) 4827 ADE12 Predicted enzyme of adenine biosynthesis; upregulated in biofilm; decreased expression in hyphae compared to yeast-form cells; not induced during GCN response, in contrast to the S. cerevisiae ortholog, which is induced by Gcn4p 3870 ADE13 Enzyme of adenine biosynthesis; soluble protein in hyphae; not induced during GCN response, in contrast to the S. cerevisiae ortholog; repressed by nitric oxide 492 ADE17 Enzyme of adenine biosynthesis; antigenic in human; soluble protein in hyphae; not induced during GCN response, in contrast to the S. cerevisiae ortholog 5906 ADE2 Phosphoribosylaminoimadazole carboxylase; enzyme of adenine biosynthesis; required for wild-type growth and virulence in immunosuppressed mouse systemic infection; not induced during GCN response, in contrast to S. cerevisiae ortholog 1233 ADE4 Predicted ORF in Assemblies 19, 20 and 21; flucytosine induced 5061 ADE5,7 Enzyme of adenine biosynthesis; interacts with Vps34p; required for hyphal growth and virulence; flucytosine induced; not induced during GCN response, in contrast to the S. cerevisiae ortholog 6317 ADE6 Enzyme of adenine biosynthesis; not induced during GCN response, in contrast to the S. cerevisiae ortholog; protein detected by mass spec in stationary phase cultures 5789 ADE8 Predicted enzyme of amino acid biosynthesis; upregulated in biofilm; S. cerevisiae ortholog is Gcn4p regulated; protein detected by mass spec in stationary phase cultures 3997 ADH1 Alcohol dehydrogenase; at yeast-form but not hyphal cell surface; soluble in hyphae; immunogenic in human or mouse; complements S. cerevisiae adh1 adh2 adh3 mutation; regulated by growth phase, carbon source; fluconazole-, farnesol-induced 5113 ADH2 Putative alcohol dehydrogenase; soluble protein in hyphae; fungal-specific (no human or murine homolog); expression is regulated upon white-opaque switching; regulated by Ssn6p; transcriptionally activated by Mnl1p under weak acid stress 4505 ADH3 Expression is regulated upon white-opaque switching; induced by nitric oxide in yhb1 mutant 271 ADH4 Protein not essential for viability; transcription is increased in an azole-resistant strain overexpressing MDR1; transcription is increased in populations of cells exposed to fluconazole over multiple generations 2608 ADH5 Putative alcohol dehydrogenase; soluble protein in hyphae; expression is regulated upon white-opaque switching; fluconazole-induced; antigenic during murine systemic infection; regulated by Nrg1p, Tup1p; macrophage-downregulated protein 3391 ADK1 Protein described as adenylate kinase; decreased expression in hyphae compared to yeast-form cells; macrophage-induced protein; adenylate kinase release can be used as a marker for cell lysis 5591 ADO1 Putative protein of unknown function; heterozygous null mutant exhibits resistance to cordycepin in the C. albicans fitness test; ketoconazole-induced; protein level decreased in stationary phase cultures 459 ADP1 Putative PDR-subfamily ABC transporter; similar to WHITE subfamily proteins; gene used for strain identification by multilocus sequence typing 2752 ADR1 Putative transcription factor with zinc finger DNA-binding motif; similar to S. cerevisiae Adr1p but mutant phenotype suggests that it has a different set of target genes; transposon mutation affects filamentous growth 4743 AFG1 Protein not essential for viability; similar to S. cerevisiae Afg1p, which is a putative mitochondrial ATPase of the AAA family 1669 AFG3 Protein likely to be essential for growth, based on an insertional mutagenesis strategy; similar to S. cerevisiae Afg3p, which is a subunit of the mitochondrial inner membrane m-AAA protease 935 AGA1 Protein with some similarity to agglutinin subunit; expression is regulated upon white-opaque switching 3050 AGE1 Protein described as a GTPase activator; transcriptionally regulated by iron; expression greater in low iron 5013 AGM1 Phosphoacetylglucosamine mutase (N-acetylglucosamine-phosphate mutase); enzyme of UDP-N-acetylglucosamine (UDP-GlcNAc) biosynthesis 4679 AGP2 Protein described as an amino acid permease; hyphal downregulated; regulated upon white-opaque switching; induced in core caspofungin response, during cell wall regeneration, or by flucytosine; fungal-specific (no human or murine homolog) 3795 AGP3 Putative serine transporter with possible role in assimilation of sulfur; induced upon early biofilm formation; fungal-specific (no human or murine homolog) 2762 AHP1 Putative alkyl hydroperoxide reductase; immunogenic in mouse; biofilm-induced; fluconazole-induced; amphotericin B, caspofungin, alkaline downregulated; induced in core stress response; regulated by Ssk1p, Nrg1p, Tup1p, Ssn6p, Hog1p 6470 AHP2 Predicted ORF in Assemblies 19, 20 and 21; macrophage-downregulated gene 300 AIP2 Protein described as an actin interacting protein; regulated by Gcn4p; induced in response to amino acid starvation (3-aminotriazole treatment); repressed in the presence of elevated CO2 5357 AKL1 Protein induced during the mating process 4950 AKR1 Ankyrin-repeat protein; increased transcription is observed upon fluphenazine treatment 5746 ALA1 Alanyl-tRNA synthetase; translational regulation generates cytoplasmic and mitochondrial forms; regulated by Gcn4p; repressed upon amino acid starvation (3-AT); translation-related genes downregulated upon phagocytosis by murine macrophage 5806 ALD5 Protein described as an aldehyde dehydrogenase; decreased expression in fluconazole-resistant isolate, or in hyphae; biofilm induced;fluconazole-downregulated; protein abundance is affected by URA3 expression in the CAI-4 strain background 742 ALD6 Putative aldehyde dehydrogenase; expression is regulated upon white-opaque switching; protein detected by mass spec in stationary phase cultures; transcription is upregulated in both intermediate and mature biofilms 4410 ALG1 Protein likely to be essential for growth, based on an insertional mutagenesis strategy; similar to S. cerevisiae Alg1p, which is a mannosyltransferase involved in N-linked protein glycosylation 3468 ALG11 Protein with similarity to mannosyltransferases 1221 ALG2 Putative mannosyltransferase involved in cell wall mannan biosynthesis; transcription is elevated in chk1, nik1, and sln1 homozygous null mutants 2837 ALG5 Putative glucosyltransferase involved in cell wall mannan biosynthesis 1843 ALG6 Putative glucosyltransferase involved in cell wall mannan biosynthesis; transcription is elevated in chk1, nik1, and sln1 homozygous null mutants; repressed by nitric oxide 2187 ALG7 Protein involved in cell wall mannan biosynthesis; mutation confers hypersensitivity to tunicamycin; transcription is elevated in chk1, nik1, and sln1 homozygous null mutants 1659 ALG8 Putative glucosyltransferase involved in cell wall mannan biosynthesis; transcription is elevated in nik1 and sln1 homozygous null mutants, but not in the chk1 null mutant 4442 ALG9 Putative mannosyltransferase; similar to S. cerevisiae Alg9p; has HKEXRF motif 6574 ALK6 Protein described as cytochrome P-450 of N-alkane-induced detoxification; macrophage-induced gene 10 ALK8 Alkane-inducible cytochrome P450; catalyzes hydroxylation of lauric acid to hydroxylauric acid; overproduction causes fluconazole resistance in a wild-type background and causes multidrug resistance in a cdr1 cdr2 double mutant background 7551 ALO1 D-Arabinono-1,4-lactone oxidase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone, which has a protective role against oxidative damage; required for full virulence in a mouse model of systemic infection 2337 ALP1 Putative high-affinity basic amino acid permease; fungal-specific (no human or murine homolog) 1607 ALR1 Putative transporter of divalent cations; hyphal-induced expression; fungal-specific (no human or murine homolog) 5741 ALS1 Adhesin; ALS family of cell-surface glycoproteins; adhesion, virulence roles; immunoprotective; in band at hyphal base; amyloid domain; biofilm-induced; Rfg1p, Ssk1p, growth-regulated; strain background affects expression 2355 ALS10 ALS family protein; ALS family includes cell-surface glycoproteins, some with adhesin function; putative GPI-anchor; filament induced; regulated by Nrg1p, Rfg1p, Tup1p; merged with orf19.1816 in Assembly 20 5745 ALS11 ALS family protein; ALS family includes cell-surface glycoproteins, some with adhesin function; putative GPI-anchor; merged with orf19.5742 in Assembly 20 2122 ALS12 ALS family protein which includes cell-surface glycoproteins, some with adhesin function; putative GPI-anchor; induced by ketoconazole, low iron and during cell wall regeneration; regulated by Sfu1p; merged with orf19.1097 in Assembly 20 1097 ALS2 ALS family protein; role in adhesion, biofilm formation, germ tube induction; expressed at infection of human buccal epithelial cells; putative GPI-anchor; induced by ketoconazole, low iron and at cell wall regeneration; regulated by Sfu1p 1816 ALS3 Adhesin; ALS family; role in epithelial adhesion, endothelial invasiveness; allelic variation in adhesiveness; immunoprotective in mice; predicted GPI-anchor cell wall protein; macrophage, hyphal induced, pH, Nrg1p, Rfg1p, Tup1p regulated 4555 ALS4 ALS family protein; role in adhesion and wild-type germ tube induction; growth and temperature regulated; expressed during infection of human buccal epithelial cells; down-regulated upon vaginal contact; putative GPI-anchored 5736 ALS5 Adhesin; ALS family protein; highly variable; expression in S. cerevisiae causes adhesion to human epithelium, endothelium or ECM, endothelial invasiveness by endocytosis, and, at high abundance, ECM-induced aggregation; has amyloid domain 7414 ALS6 ALS family protein; expression in S. cerevisiae confers adhesion to gelatin; macrophage-induced gene; N-terminal adhesion domain; ALS family includes cell-surface glycoproteins, some with adhesin function 7400 ALS7 ALS family protein; hypermutable contingency gene; growth-regulated, downregulated in biofilm; two variable repeat regions; expression in S. cerevisiae does not confer adhesiveness; ALS family includes adhesins, cell-surface glycoproteins 5742 ALS9 ALS family protein; expressed during infection of human epithelial cells; confers laminin adhesion to S. cerevisiae; highly variable; ALS family includes cell-surface glycoproteins, some with adhesin function; putative GPI-anchor 3152 AMO2 Protein similar to A. niger predicted peroxisomal copper amino oxidase; mutation confers hypersensitivity to toxic ergosterol analog; induced upon biofilm formation 2768 AMS1 Putative alpha-mannosidase; transcription is regulated by Nrg1p; induced during cell wall regeneration 3426 ANB1 Putative translation initiation factor; decreased expression in hyphae compared to yeast-form cells; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 3622 ANP1 Putative mannosyltransferase of Golgi; member of Mnn9p family; similar to S. cerevisiae Anp1p; fungal-specific (no human or murine homolog) 6254 ANT1 Predicted ORF in Assemblies 19, 20 and 21 4774 AOX1 Alternative oxidase; low abundance; constitutively expressed; one of two isoforms (Aox1p and Aox2p); involved in a cyanide-resistant respiratory pathway present in plants, protists, and some fungi, although absent from S. cerevisiae 4773 AOX2 Alternative oxidase; induced by antimycin A, some oxidants; growth- and carbon-source-regulated; one of two isoforms (Aox1p and Aox2p); involved in cyanide-resistant respiratory pathway that is absent from S. cerevisiae 5630 APA2 Protein described as ATP adenylyltransferase II; regulated by Gcn4p; repressed in response to amino acid starvation (3-aminotriazole treatment); increased expression in response to prostaglandins 6046 APC1 Predicted ORF in Assemblies 19, 20 and 21; essential for growth; periodic mRNA expression, peak at cell-cycle S/G2 phase 5197 APE2 Neutral arginine-, alanine-, leucine-specific metallo-aminopeptidase; expected to be secreted, purified from cell wall and intracellular fractions; protein repressed during the mating process; Hog1p-, farnesol-induced 3591 APE3 Predicted ORF in Assemblies 19, 20 and 21; regulated by Gcn2p and Gcn4p 707 APG7 Protein not essential for viability; similar to S. cerevisiae Atg7p, which is an E1 protein conjugation enzyme involved in protein-vacuolar targeting and autophagy 231 APL2 Phosphorylated protein of unknown function; mutation confers hypersensitivity to toxic ergosterol analog; predicted ORF in Assemblies 19, 20 and 21 248 APL5 Phosphorylated protein, not essential for viability; similar to S. cerevisiae Apl5p, which is a subunit of the AP-3 adaptor complex involved in Golgi-to-vacuole transport 4036 APM1 Phosphorylated protein similar to S. cerevisiae Apm1, which is involved in vesicle transport; transposon mutation affects filamentous growth 7428 APN1 Ortholog of S. cerevisiae Apn1p, which is an AP endonuclease; transcriptionally induced by interaction with macrophage; fungal-specific (no human or murine homolog) 1836 APN2 Predicted ORF in Assemblies 19, 20 and 21; flucytosine induced 1448 APT1 Predicted ORF in Assemblies 19, 20 and 21; flucytosine induced; repressed by nitric oxide; protein level decreased in stationary phase cultures 2849 AQY1 Aquaporin water channel; mutant has increased resistance to osmotic shock; required for wild-type tolerance of freezing; not required for virulence in a mouse model of systemic infection; flucytosine repressed 2172 ARA1 D-Arabinose dehydrogenase; in dehydro-D-arabinono-1,4-lactone biosynthesis; NADP+ cofactor; active toward D-arabinose, L-fucose, L-xylose, L-galactose; inhibited by metal ions, thiol group-specific reagents; induced on polystyrene adherence 2422 ARC1 Predicted ORF in Assemblies 19, 20 and 21; macrophage/pseudohyphal-repressed; protein detected by mass spec in stationary phase cultures 6151 ARC15 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to cytochalasin D 121 ARC18 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to cytochalasin D 3251 ARC19 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to cytochalasin D 2437 ARC35 Predicted ORF in Assemblies 19, 20 and 21; shows colony morphology-related gene regulation by Ssn6p; mutation confers hypersensitivity to cytochalasin D 3873 ARC40 Protein similar to S. cerevisiae Arc40p, which is involved in actin filament organization in S. cerevisiae; transposon mutation affects filamentous growth 6322 ARD D-arabitol dehydrogenase, NAD-dependent (ArDH); enzyme of D-arabitol and D-arabinose catabolism; D-arabitol is a marker for active infection in humans; has conserved YXXXK motif of short-chain alcohol-polyol-sugar dehydrogenases 2248 ARE2 Acyl CoA:sterol acyltransferase (ASAT); uses cholesterol and oleoyl-CoA substrates; protoberberine derivative drug inhibits enzyme activity; 7 putative transmembrane regions; ketoconazole-induced 6447 ARF1 ADP-ribosylation factor, probable GTPase involved in intracellular transport; one of several C. albicans ADP-ribosylation factors; N-myristoylprotein; substrate of Nmt1p 5964 ARF2 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to Brefeldin A 1702 ARF3 Transcription is filament induced; Tup1p regulated (see Locus History Note for Assembly 19 correction) 7469 ARG1 Similar to argininosuccinate synthase; enzyme of arginine biosynthesis; increased transcription is observed upon benomyl treatment; regulated by Gcn4p, Rim101p; induced in response to amino acid starvation (3-aminotriazole treatment) 5926 ARG11 Protein induced during the mating process 56 ARG2 Putative enzyme of arginine biosynthesis; transcription of genes of arginine biosynthesis pathway, except for ARG2, is induced upon phagocytosis by macrophage 5610 ARG3 Alkaline downregulated; Gcn4p-regulated 6689 ARG4 Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway; alkaline downregulated 4788 ARG5,6 Arginine biosynthetic enzyme activities; in S. cerevisiae, processed into distinct polypeptides with acetylglutamate kinase (Arg6p) activity and acetylglutamate-phosphate reductase (Arg5p) activity; Gcn4p regulated; alkaline downregulated 3770 ARG8 Predicted ORF in Assemblies 19, 20 and 21; Gcn2p-, Gcn4p-regulated; transcription is upregulated in both intermediate and mature biofilms 3521 ARH2 Predicted ORF in Assemblies 19, 20 and 21 4603 ARL1 Predicted ORF in Assemblies 19, 20 and 21; mutation confers dose-dependent sensitivity to Brefeldin A 2297 ARL3 Predicted ORF in Assemblies 19, 20 and 21; induced by nitric oxide in yhb1 mutant 4704 ARO1 Putative pentafunctional arom enzyme; fungal-specific (no human or murine homolog); Gcn2p-, Gcn4p-regulated 1847 ARO10 Aromatic decarboxylase of the Ehrlich fusel oil pathway of aromatic alcohol biosynthesis; pH-regulated (alkaline downregulated); protein abundance is affected by URA3 expression in the CAI-4 strain background 1986 ARO2 Putative chorismate synthase; fungal-specific (no human or murine homolog); protein level decreased in stationary phase cultures 3489 ARO22 Putative chorismate synthase; fungal-specific (no human or murine homolog); merged with orf19.1986 in Assembly 20 1517 ARO3 3-Deoxy-D-arabinoheptulosonate-7-phosphate synthase; enzyme of aromatic amino acid biosynthesis; GCN-regulated; feedback-inhibited by phenylalanine when heterologously produced in S. cerevisiae; Aro3p and Aro4p catalyze the same reaction 4060 ARO4 3-Deoxy-D-arabinoheptulosonate-7-phosphate synthase; enzyme of aromatic amino acid biosynthesis; GCN-regulated; feedback-inhibited by tyrosine when produced in S. cerevisiae; fungal-specific; Aro3p and Aro4p catalyze the same reaction 1170 ARO7 Putative chorismate mutase; fungal-specific (no human or murine homolog); alkaline upregulated 2098 ARO8 Aromatic transaminase of the Ehrlich fusel oil pathway of aromatic alcohol biosynthesis; Rim101p-independent pH-regulation (alkaline induced); protein abundance is affected by URA3 expression in the CAI-4 strain background; Gcn4p-regulated 3012 ARO80 Regulator of aromatic alcohol biosynthesis via the Ehrlich pathway; not essential for viability; similar to S. cerevisiae Aro80p, which is a transcriptional activator required for aromatic amino acid catabolism 1237 ARO9 Aromatic transaminase of the Ehrlich fusel oil pathway of aromatic alcohol biosynthesis; Rim101p-dependent pH-regulation (alkaline induced) 2641 ARP1 Protein described as centractin; induced upon adherence to polystyrene 7292 ARP2 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to cytochalasin D; regulated by Gcn2p and Gcn4p 2289 ARP3 Predicted ORF in Assemblies 19, 20 and 21; shows Myo5p-dependent localization to cortical actin patches at hyphal tip; mutation confers hypersensitivity to cytochalasin D 5623 ARP4 Subunit of the NuA4 histone acetyltransferase complex 3359 ARP8 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to toxic ergosterol analog, and to amphotericin B 2507 ARP9 Protein likely to be essential for growth, based on an insertional mutagenesis strategy; similar to S. cerevisiae Arp3p, which is a component of the Arp2/3 complex involved in actin-dependent processes 3122 ARR3 Protein not essential for viability; similar to S. cerevisiae Arr3p, which is an arsenite transporter of the plasma membrane required for resistance to arsenic compounds; benomyl-induced; Gcn4p-regulated 3015 ARX1 Predicted ORF in Assemblies 19, 20 and 21; downregulated during core stress response; decreased expression in response to prostaglandins 6906 ASC1 40S ribosomal subunit protein; similar to G-beta subunits; antigenic in human, murine infection; soluble in hyphae; iron, temperature, Gcn4p regulated; amino acid starvation (3-aminotriazole)-, caspofungin-, farnesol-downregulated 7377 ASE1 Predicted ORF in Assemblies 19, 20 and 21; member of conserved Mcm1p regulon; periodic mRNA expression, peak at cell-cycle G2/M phase 3715 ASF1 Protein likely to be essential for growth, based on an insertional mutagenesis strategy; similar to S. cerevisiae Asf1p, which is a chromatin assembly complex component 166 ASG1 Predicted zinc-finger protein of unknown function; has similarity to S. cerevisiae Asg1p, which is a proposed transcription factor of the Gal4p family 5520 ASG7 Predicted ORF in Assemblies 19, 20 and 21; specific to a-cells; transcription is induced in response to alpha pheromone in SpiderM medium; member of conserved Mcm1p regulon 5343 ASH1 GATA-like transcription factor; localizes to nuclei of daughter cells and hyphal tip cells; required for wild-type virulence but not kidney colonization in a mouse model of systemic infection; required for wild-type filamentous growth 3964 ASH2 Predicted ORF in Assemblies 19, 20 and 21 6037 ASM3 Putative secreted acid sphingomyelin phosphodiesterase; induced upon biofilm formation; possible Kex2p substrate; increased transcription is observed in an azole-resistant strain that overexpresses MDR1 198 ASN1 Protein described as asparagine synthetase; soluble protein in hyphae; regulated by Rim101p; decreased expression at pH 4 compared to pH 8 2344 ASR1 Protein described as similar to heat shock proteins; transcription regulated by cAMP, osmotic stress, ciclopirox olamine, ketoconazole; negatively regulated by Cyr1p, Ras1p; shows colony morphology-related gene regulation by Ssn6p 7284 ASR2 Gene regulated by cAMP and by osmotic stress; greater mRNA abundance observed in a cyr1 or ras1 homozygous null mutant than in wild type; protein detected by mass spec in stationary phase cultures 842 ASR3 Gene regulated by cAMP and by osmotic stress; greater mRNA abundance observed in a cyr1 or ras1 homozygous null mutant than in wild type; possibly spurious ORF (Annotation Working Group prediction) 6214 ATC1 Cell wall acid trehalase; catalyzes hydrolysis of the disaccharide trehalose; similar to S. cerevisiae vacuolar acid trehalase (Ath1p) 5877 ATF1 Putative alcohol acetyltransferase; caspofungin repressed; expression depends on Tac1p 3412 ATG15 Putative lipase; fungal-specific (no human or murine homolog) 5974 ATG9 Protein similar to S. cerevisiae Atg9p, required for an early step in autophagy; required for cytoplasm to vacuole trafficking of Lap41p 1077 ATM1 Member of MDR subfamily of ABC family; similar to S. cerevisiae ABC transporter, Atm1p; transcriptionally regulated by iron; expression greater in low iron; induced by nitric oxide in yhb1 mutant 6854 ATP1 Protein similar to alpha subunit of ATP synthase; antigenic in human, mouse; at surface of hyphae, not yeast-form; soluble protein in hyphae; induced by ciclopirox olamine, ketoconazole, or flucytosine; downregulated by Efg1p, caspofungin 5491.1 ATP14 ORF Predicted by Annotation Working Group; macrophage/pseudohyphal-induced 7509.1 ATP17 Protein described as a component of mitochondrial ATPase complex; downregulated by Efg1p; flucytosine induced; caspofungin repressed 5653 ATP2 Protein described as a similar to F1 beta subunit of F1F0 ATPase complex; antigenic in human, mouse; transcription upregulated in response to ciclopirox olamine; flucytosine induced; caspofungin repressed; macrophage/pseudohyphal-induced 3757 ATP20 Predicted ORF in Assemblies 19, 20 and 21; shows colony morphology-related gene regulation by Ssn6p; flucytosine induced; caspofungin repressed; macrophage/pseudohyphal-induced 3223 ATP3 Predicted ORF in Assemblies 19, 20 and 21; flucytosine induced; caspofungin repressed; macrophage/pseudohyphal-induced 3579 ATP4 Predicted ORF in Assemblies 19, 20 and 21; macrophage/pseudohyphal-induced 5419 ATP5 Predicted ORF in Assemblies 19, 20 and 21; caspofungin repressed; protein level decreased in stationary phase cultures 2785 ATP7 Putative subunit of the F1F0-ATPase complex; shows colony morphology-related gene regulation by Ssn6p; farnesol-, macrophage-downregulated protein abundance 6399 ATS1 Induced upon adherence to polystyrene 2369.1 ATX1 ORF Predicted by Annotation Working Group; flucytosine induced; decreased expression observed in an ssr1 homozygous null mutant 1945 AUR1 Inositolphosphorylceramide (IPC) synthase, catalyzes the key step in the synthesis of sphingolipids; target for antifungal drugs; mutation confers hypersensitivity to aureobasidin A 2480.1 AUT7 ORF Predicted by Annotation Working Group; macrophage/pseudohyphal-repressed; intron in 5'-UTR 5496 AVT1 Predicted ORF in Assemblies 19, 20 and 21 905 AVT7 Predicted ORF in Assemblies 19, 20 and 21; similar to S. cerevisiae Avt7p; downregulated upon adherence to polystyrene; constitutive expression independent of MTL or white-opaque status 7342 AXL1 Protein of unknown function, induced by alpha factor; transcription is upregulated in an RHE model of oral candidiasis and in clinical isolates from HIV+ patients with oral candidiasis 5292 AXL2 Protein not essential for viability; similar to S. cerevisiae Axl2p, which is a plasma membrane protein involved in determination of budding pattern; O-glycosylated by Pmt4p 6167 AYR1 Protein described as putative oxidoreductase; transcriptionally induced by interaction with macrophage 5615 AYR2 Predicted ORF in Assemblies 19, 20 and 21; shows colony morphology-related gene regulation by Ssn6p 797 BAT21 Protein described as a branched chain amino acid aminotransferase; regulated by Gcn4p, Gcn2p; induced in response to amino acid starvation (3-aminotriazole treatment) 6994 BAT22 Protein described as a branched chain amino acid aminotransferase; regulated by Gcn4p; induced in response to amino acid starvation (3-aminotriazole treatment), farnesol treatment 5162 BCK1 Predicted ORF in Assemblies 19, 20 and 21; similar to S. cerevisiae Bck1p MAP kinase kinase kinase of cell integrity pathway 723 BCR1 Transcription factor required for wild-type biofilm formation; not required for hyphal growth; regulates cell-surface-associated genes; has C2H2 zinc finger; filament induced; Tup1p-, Tec1p-, Mnl1p-regulated 2014 BCY1 Regulatory subunit of protein kinase A; required for nuclear localization of Tpk1p; physically interacts with Tpk1p; essential for viability; apoptosis-regulated; bcy1 heterozygous or bcy1 tpk2 mutant has filamentous growth defect 978 BDF1 Putative transcription factor; downregulated upon adherence to polystyrene; reduced mRNA abundance detected in homozygous fkh2 null mutant; macrophage/pseudohyphal-repressed 4645 BEM1 Protein required for wild-type budding, hyphal growth, and virulence in a mouse systemic infection; suppresses pseudohyphal and filamentous growth defects of various S. cerevisiae mutants and heat sensitivity of S. cerevisiae cdc24-4 mutant 6573 BEM2 Putative Rho1p GTPase activating protein (GAP); serum-induced transcription 2771 BEM3 Putative GTPase-activating protein (GAP) for Rho-type GTPase Cdc42p; involved in cell signaling pathways that control cell polarity; similar to S. cerevisiae Bem3p 7563 BET2 Transcription is regulated by Mig1p 4560 BFR1 Predicted ORF in Assemblies 19, 20 and 21; protein detected by mass spec in stationary phase cultures 4565 BGL2 1,3-beta-Glucosyltransferase, cell wall enzyme; one of multiple 1,3-beta-glucosyltransferases; mutant has cell-wall and growth defects, but wild-type 1,3- or 1,6-beta-glucan content; antigenic; virulence role in mouse systemic infection 7339 BGL22 Putative glucanase; induced during cell wall regeneration 2334 BIG1 Protein of the endoplasmic reticulum required for beta-1,6-glucan synthesis, filamentation, adhesion, and virulence; ortholog of S. cerevisiae Big1p 2593 BIO2 Protein described as biotin synthase; transcriptionally upregulated in high iron; transcription is downregulated in response to treatment with ciclopirox olamine; upregulated in clinical isolates from HIV+ patients with oral candidiasis 3567 BIO32 Predicted ORF in Assemblies 19, 20 and 21; induced during planktonic growth 2182 BLM3 Predicted ORF in Assemblies 19, 20 and 21; similar to S. cerevisiae Blm10p; transcription is regulated by Nrg1p and Mig1p 3014 BMH1 14-3-3 protein, role in hyphal growth; possibly regulated by host interaction; sole 14-3-3 protein in C. albicans while S. cerevisiae has two 14-3-3 proteins; localizes to cell surface of yeast-form cells but not of hyphae; intron in 5'-UTR 2504 BMS1 Predicted ORF in Assemblies 19, 20 and 21; mutation confers resistance to 5-fluorocytosine (5-FC); flucytosine induced; decreased expression in response to prostaglandins 6782 BMT1 Putative beta-mannosyltransferase, required for addition of the first beta-mannose residue to the acid-stable fraction of cell wall phosphopeptidomannan; member of a 9-gene family; predicted ORF in Assemblies 19, 20 and 21 3282 BMT3 Putative beta-mannosyltransferase, required for addition of the 2nd beta-mannose to the acid-stable fraction of cell wall phosphopeptidomannan and for elongation of beta-mannose chains on the phosphopeptidomannan acid-labile fraction 5612 BMT4 Putative beta-mannosyltransferase, required for elongation of beta-mannose chains on the acid-labile fraction of cell wall phosphopeptidomannan; member of a 9-gene family; regulated by Tsa1p, Tsa1Bp 1464 BMT5 Putative beta-mannosyltransferase, member of a 9-gene family that includes characterized genes BMT1, BMT2, BMT3, and BMT4 with roles in beta-1,2-mannosylation of cell wall phosphopeptidomannan; predicted ORF in Assemblies 19, 20 and 21 5602 BMT6 Putative beta-mannosyltransferase, member of a 9-gene family that includes characterized genes BMT1, BMT2, BMT3, and BMT4 with roles in beta-1,2-mannosylation of cell wall phosphopeptidomannan; predicted ORF in Assemblies 19, 20 and 21 342 BMT7 Putative beta-mannosyltransferase, member of a 9-gene family that includes characterized genes BMT1, BMT2, BMT3, and BMT4 with roles in beta-1,2-mannosylation of cell wall phosphopeptidomannan; downregulated in an azole-resistant strain 860 BMT8 Putative beta-mannosyltransferase, member of a 9-gene family that includes characterized genes BMT1, BMT2, BMT3, and BMT4 with roles in beta-1,2-mannosylation of cell wall phosphopeptidomannan; predicted ORF in Assemblies 19, 20 and 21 4673 BMT9 Putative beta-mannosyltransferase, member of a 9-gene family that includes characterized genes BMT1, BMT2, BMT3, and BMT4 with roles in beta-1,2-mannosylation of cell wall phosphopeptidomannan; predicted ORF in Assemblies 19, 20 and 21 4927 BNI1 Formin; role in cytoskeletal organization, cell polarity; role in systemic virulence in mouse; cell-cycle regulated localization to site of polarized growth, bud neck; localizes to Spitzenkorper of hyphae, minor localization at septum 4457 BNI4 Protein required for wild-type cell wall chitin distribution, morphology, hyphal growth; not essential; similar to S. cerevisiae Bni4p (targeting subunit for Glc7p phosphatase, involved in bud-neck localization of chitin synthase III) 7537 BNR1 Formin; probable role in hyphal cytoskeletal polarity; synthetic lethality if Bnr1p and Bni1p are absent 3230 BOI2 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to toxic ergosterol analog 6261 BPH1 Protein not essential for viability; similar to S. cerevisiae Bph1p, which is a putative ortholog of human Chediak-Higashi syndrome protein and murine beige gene implicated in disease syndromes involving defective lysosomal trafficking 976 BRE1 Putative transcription factor with C3HC4 zinc finger DNA-binding motif; similar to S. cerevisiae Bre1p; transposon mutation affects filamentous growth 6649 BRF1 Component of the general transcription factor for RNA polymerase III (TFIIIB) 1251 BRN1 Predicted ORF in Assemblies 19, 20 and 21; cell-cycle regulated periodic mRNA expression 1670 BRO1 Protein involved in transport from multivesicular body to vacuole; similar to S. cerevisiae Bro1p, which is a class E vacuolar protein sorting (VPS) factor; not involved in RIM101 pathway; macrophage/pseudohyphal-repressed 6674 BTS1 Decreased transcription is observed upon benomyl treatment 2678 BUB1 Predicted ORF in Assemblies 19, 20 and 21; mutation confers increased sensitivity to nocodazole 5827 BUB2 Predicted ORF in Assemblies 19, 20 and 21; described as similar to S. cerevisiae Bub2p; mutation confers hypersensitivity to amphotericin B; induced upon adherence to polystyrene; fungal-specific (no human or murine homolog) 2655 BUB3 Protein similar to S. cerevisiae Bub3p, which is a kinetochore checkpoint component; induced under hydroxyurea treatment 1828 BUD16 Protein similar to S. cerevisiae Bud16p; induced in response to alpha pheromone in SpiderM medium 940 BUD2 GTPase activating protein (GAP) for Rsr1p; negative regulator of filament branching, acts in hyphal growth guidance; required for wild-type budding pattern; expression greater in low iron; regulated by tyrosol and cell density 218 BUD20 Protein similar to S. cerevisiae Bud20p, which affects bud site selection; transposon mutation affects filamentous growth 5430 BUD21 Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins 3287 BUD22 Predicted ORF in Assemblies 19, 20 and 21; downregulated during core stress response; decreased expression in response to prostaglandins 1966 BUD23 Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins 4855 BUD31 Not subject to mating-type regulation, in contrast to the S. cerevisiae ortholog, which has a role in specification of the bud site 5087 BUD6 Protein required for Spitzenkorper formation in hyphal cells (wild-type localization of Mlc1p to the Spitzenkorper); localizes to polarisome 1112 BUD7 Predicted ORF in Assemblies 19, 20 and 21; fungal-specific (no human or murine homolog) 5094 BUL1 Protein not essential for viability; macrophage/pseudohyphal-induced; similar to S. cerevisiae Bul1p, which may be involved in selection of substrates for ubiquitination 4284 BUR2 Protein with similarity to S. cerevisiae Bur2p, contains a cyclin domain; not required for wild-type hyphal growth, adherence to buccal epithelial cells, or virulence in mouse systemic infection 1699 BZZ1 Protein similar to S. cerevisiae Bzz1p, which is an SH3 domain protein involved in the regulation of actin polymerization 6670 CAC2 Predicted ORF in Assemblies 19, 20 and 21; macrophage-induced gene 388 CAF16 ABC family protein, predicted not to be a transporter; caspofungin repressed 4015 CAG1 Alpha subunit of heterotrimeric G protein; positive role in mating pheromone response; more mRNA in opaque than white cells; transcriptionally repressed by MTLa1p-MTLalpha2p complex; regulated by hemoglobin-responsive Hbr1p via MTL genes 793 CAK1 Monomeric CDK-activating kinase (CAK); functional homolog of S. cerevisiae Cak1p; phosphorylates cyclin-free human CDK2; lacks glycine loop motif; conserved lysine (K36) not required for activity 7382 CAM1 Putative translation elongation factor eEF1 gamma; protein level decreased in stationary phase cultures 2651 CAM1-1 Putative translation elongation factor; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 97 CAN1 Amino acid permease, transports basic amino acids; complements lysine transport mutation; contains 10 predicted transmembrane regions and 3 predicted N-glycosylation sites; transcriptionally induced upon phagocytosis by macrophage 111 CAN2 Putative amino acid permease; transcription is regulated by Nrg1p and Tup1p; caspofungin induced; flucytosine induced; shows colony morphology-related gene regulation by Ssn6p; ; fungal-specific (no human or murine homolog) 84 CAN3 Predicted ORF in Assemblies 19, 20 and 21; expression is regulated upon white-opaque switching 1623 CAP1 Transcription factor, AP-1 family; role in oxidative stress response and resistance, multidrug resistance; oxidative stress regulates nuclear localization; partially complements S. cerevisiae yap1 mutation; human neutrophil-induced 3934 CAR1 Transcription is regulated by Nrg1p, Mig1p, and Tup1p; shows colony morphology-related gene regulation by Ssn6p; alkaline upregulated; protein level decreased in stationary phase cultures 5641 CAR2 Alkaline upregulated; mutation confers hypersensitivity to toxic ergosterol analog, and to amphotericin B 1135 CAS1 Putative transcription factor with beta-barrel DNA-binding motif; mutation causes marginal increase in caspofungin sensitivity 1693 CAS4 Protein of RAM cell wall integrity signaling network; role in cell separation, azole sensitivity; required for hyphal growth; insertion mutation near 3' end of gene causes increase in caspofungin sensitivity; pheromone/hyphal induced 4670 CAS5 Putative zinc finger transcription factor; cell wall damage response; required for wild-type transcriptional response to caspofungin; mutant caspofungin hypersensitive; downregulated in core stress response; avirulent, reduced CFU in mice 6229 CAT1 Catalase; role in resistance to oxidative stress, neutrophils, peroxide; role in murine systemic virulence; regulated by iron, ciclopirox olamine, fluconazole, growth, carbon source, pH, Rim101p, Ssn6p, Hog1p, farnesol, core stress response 4591 CAT2 Major carnitine acetyl transferase localized in peroxisomes and mitochondria; involved in intracellular acetyl-CoA transport; transcriptionally induced in macrophage; farnesol-upregulated in biofilm; Hog1p-downregulated 5097 CAT8 Predicted zinc-cluster protein; null mutant shows a defect in transcription of JEN1 lactate permease gene; flucytosine repressed; similar to S. cerevisiae Cat8p but mutant phenotype suggests that it has a different set of target genes 2876 CBF1 Transcription factor that binds to a conserved sequence at ribosomal protein genes and the rDNA locus, with Tbf1p; also regulates sulfur starvation-response and other genes; binds centromeres and has a role in centromere maintenance 4909 CBK1 Putative S/T kinase of cell wall integrity pathway; required for hyphal growth; mutant cells show abnormal morphology and aggregation; Mob2p associated; required for wild-type transcriptional regulation of several cell-wall-associated genes 7323 CBP1 Corticosteroid binding protein; transcription induced at late log-phase or upon adherence to polystyrene; not induced by corticosterone; contains a possible NAD/FAD binding region; regulated by Nrg1p, Tup1p 6948 CCC1 Protein described as predicted manganese transporter; alkaline downregulated; shows colony morphology-related gene regulation by Ssn6p; repressed by nitric oxide 4328 CCC2 Copper-transporting P-type ATPase of Golgi; required for wild-type iron assimilation (indirect effect via Fet3p); induced by iron starvation, ciclopirox olamine; caspofungin repressed; not required for virulence in mouse systemic infection 3264 CCE1 Putative Holliday junction resolving enzyme; similar to S. cerevisiae Cce1p 3298 CCH1 Putative voltage-gated Ca2+ channel of the high affinity calcium uptake system; roles in thigmotropism, establishment of galvanotropism; transcription is regulated by Nrg1p and Mig1p 3207 CCN1 G1 cyclin; required for hyphal growth maintenance (not initiation); cell-cycle regulated transcription (G1/S); Cdc28p-Ccn1p initiates Cdc11p S394 phosphorylation on hyphal induction; expression in S. cerevisiae inhibits pheromone response 238 CCP1 Similar to cytochrome-c peroxidase N terminus; transcription is negatively regulated by Rim101p or alkaline pH; transcription induced by interaction with macrophage or low iron; oxygen-induced activity 5101 CCR4 Protein similar to S. cerevisiae Ccr4p of the CCR4-NOT transcription regulatory complex; transposon mutation affects filamentous growth 1402 CCT2 Predicted ORF in Assemblies 19, 20 and 21; protein detected by mass spec in exponential and stationary phase cultures 4004 CCT3 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to cytochalasin D 2288 CCT5 Predicted ORF in Assemblies 19, 20 and 21. Protein detected by mass spec in exponential and stationary phase cultures. 3126 CCT6 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to cytochalasin D 3206 CCT7 Predicted ORF in Assemblies 19, 20 and 21. Protein detected by mass spec in exponential and stationary phase cultures. 6099 CCT8 Essential protein similar to chaperonin complex subunit 8; involved in hyphal morphogenesis, particularly starvation-induced; production in S. cerevisiae inhibits Ras2p-mediated pathways (including pseudohyphal); CCT1 and TRP1 genes overlap 1969 CCW14 Putative mannoprotein of cell wall with role in response to stress; increased mRNA abundance observed in cyr1 homozygous mutant (hyphal or yeast-form cells) and in ras1 homozygous mutant (yeast-form cells) 7503 CDA2 Putative protein of unknown function, transcription is positively regulated by Tbf1p; predicted ORF in Assemblies 19, 20 and 21 548 CDC10 Septin, required for wild-type cell, hyphal, or chlamydospore morphology; role in virulence and kidney tissue invasion in a mouse model of systemic infection; forms ring at sites of cell division and filaments in mature chlamydospore 5691 CDC11 Septin; required for wild-type cell and hyphal morphology, agar-invasive growth, full virulence and kidney tissue invasion in mouse, but not for kidney colonization, immunogenicity; phosphorylation is hyphal- and cell-cycle-regulated 3013 CDC12 Septin; essential for viability; gene has predicted splice sites; forms ring at sites of cell division and also forms filaments in mature chlamydospore; filamentous growth induced; regulated by Nrg1p, Tup1p, tyrosol and cell density 4192 CDC14 Protein involved in exit from mitosis and morphogenesis; ortholog of S. cerevisiae Cdc14p, which is a dual-specificity phosphatase and cell-cycle regulator; suppresses S. cerevisiae cdc15-lyt1, dbf2-2, and (partially) tem1 mutant phenotypes 3575 CDC19 Putative pyruvate kinase; on yeast-form cell surface; soluble in hyphae; antigenic; Gcn4p, Hog1p regulated; induced on polystyrene adherence; downregulated upon phagocytosis, farnesol treatment; mutation affects filamentation 122 CDC20 Protein similar to S. cerevisiae Cdc20p, which is a cell-cycle regulated activator of the anaphase promoting complex; induced under Cdc5p depletion; member of conserved Mcm1p regulon; periodic mRNA expression, peak at cell-cycle G2/M phase 3549 CDC21 Predicted ORF in Assemblies 19, 20 and 21; flucytosine induced; transcription is downregulated in both intermediate and mature biofilms 6437 CDC23 Similar to anaphase-promoting complex component; possibly transcriptionally regulated by Tac1p 3174 CDC24 GDP-GTP exchange factor for Cdc42p; phosphorylated; required for maintenance of hyphal growth; misexpression blocks hyphal growth and causes avirulence in a mouse model of systemic infection; antigenic during human oral infection 3231 CDC27 Predicted ORF in Assemblies 19, 20 and 21; periodic mRNA expression, peak at cell-cycle S/G2 phase 3856 CDC28 Cyclin-dependent protein kinase, interacts with regulatory subunit Cyb1p; involved in determination of cell morphology during the cell cycle; phosphorylated primarily by Swe1p and phosphorylation is regulated by Hsl1p; intron in 5'-UTR 1055 CDC3 Septin; essential for viability; functional homolog of S. cerevisiae Cdc3p; down-regulation associated with azole resistance; macrophage/pseudohyphal-repressed; virulence-group-correlated expression; gene has intron 6529 CDC34 Transcription is regulated by Nrg1p and Tup1p, and by Gcn2p and Gcn4p 5531 CDC37 Chaperone for Crk1p; interacts with Crk1p kinase domain and with Sti1p; putative phosphorylation site at Ser14; functional homolog of S. cerevisiae Cdc37p; likely to be essential for growth; regulated by Gcn2p and Gcn4p 1084 CDC39 Protein similar to S. cerevisiae Cdc39p, which is part of the CCR4-NOT transcription regulatory complex; transposon mutation affects filamentous growth 2559 CDC4 F-box subunit of SCF(CDC4) ubiquitin ligase; functional homolog of S. cerevisiae Cdc4p; mutation or depletion causes hyperfilamentation; nonessential; Sol1p is a substrate of SCF-Cdc4p 390 CDC42 Rho-type GTPase; required for budding and maintenance of hyphal growth; GGTase I geranylgeranylated; misexpression blocks hyphal growth, causes avirulence in mouse IV infection; shows actin-dependent localization to hyphal tip 1803 CDC43 Beta subunit of heterodimeric protein geranylgeranyltransferase type I; GGTase I enzyme binds zinc, is Mg-dependent; Cdc42p is GGTase I substrate 1988 CDC45 Protein described as a DNA replication initiation factor; transcriptionally regulated by interaction with macrophage 5487 CDC46 Protein described as having role in control of cell division; periodic mRNA expression, peak at cell-cycle M/G1 phase; regulated by tyrosol and cell density; Plc1p-regulated; repressed in response to alpha pheromone in SpiderM medium 202 CDC47 Phosphorylated protein described as having role in control of cell division; RNA abundance regulated by tyrosol and cell density; merged with orf19.201 in Assembly 20; unmerged from orf19.201 in a revision of Assembly 21 2340 CDC48 Protein described as microsomal ATPase; regulated by Gcn2p and Gcn4p; induced in response to amino acid starvation (3-aminotriazole treatment); macrophage/pseudohyphal-repressed 6010 CDC5 Polo-like kinase; probably essential for viability; depletion causes defects in spindle elongation and causes Cdc35p-dependent filamentation; member of conserved Mcm1p regulon; virulence-group-correlated expression 5735 CDC50 Predicted ORF in Assemblies 19, 20 and 21; transcriptionally activated by Mnl1p under weak acid stress 1674 CDC53 Cullin, a scaffold subunit of the SCF ubiquitin-ligase complexes; depletion leads to increased filamentous growth and premature cell death 3761 CDC54 Transcription is regulated by Nrg1p and Mig1p; periodic mRNA expression, peak at cell-cycle M/G1 phase 5242 CDC6 Predicted ORF in Assemblies 19, 20 and 21; member of conserved Mcm1p regulon; periodic mRNA expression, peak at cell-cycle M/G1 phase 2560 CDC60 Cytosolic leucyl tRNA synthetase; has conserved amino acid and ATP binding class I signature, tRNA binding, and proofreading motifs; likely essential for growth; interacts with benzoxaborole antifungals; similar to S. cerevisiae Cdc60p 2562 CDC60B Putative tRNA-Leu synthetase; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage; merged with orf19.2560 in Assembly 20 2884 CDC68 Functional homolog of S. cerevisiae Cdc68p, which is a transcription elongation factor; essential; possible drug target 3561 CDC7 Predicted ORF in Assemblies 19, 20 and 21; cell-cycle regulated periodic mRNA expression; S. cerevisiae ortholog is not cell-cycle regulated 2983 CDC73 Protein similar to S. cerevisiae Cdc73p, which is a transcription elongation factor; cdc73 kap114 double transposon mutation affects filamentous growth 7314 CDG1 Protein described as similar to cysteine dioxygenases; expression is regulated upon white-opaque switching; transcription is upregulated in both intermediate and mature biofilms 2084 CDH1 Predicted ORF in Assemblies 19, 20 and 21; transcriptionally activated by Mnl1p under weak acid stress 6000 CDR1 Multidrug transporter of ATP-binding cassette (ABC) superfamily; transports phospholipids in an in-to-out direction; transcription induced by beta-estradiol, progesterone, corticosteroid, or cholesterol 918 CDR11 Putative transporter of PDR subfamily of ABC family; Gcn4p-regulated; upregulated by Rim101p at pH 8 5958 CDR2 Multidrug transporter, ATP-binding cassette (ABC) superfamily; transports phospholipids, in-to-out direction; low mRNA level; overexpressed in azole-resistant isolates; expression confers multidrug resistance to S. cerevisiae pdr5 mutant 1313 CDR3 Transporter of the Pdrp/Cdrp family of the ATP-binding cassette (ABC) superfamily; transports phospholipids in an out-to-in direction; expressed in opaque-phase cells; induced by macrophage interaction; fluconazole-downregulated 5079 CDR4 Putative transporter of ATP-binding cassette (ABC) superfamily; fluconazole, Sfu1p, Hog1p, core stress response induced; caspofungin repressed; fluconazole resistance is not affected by mutation or correlated with expression 1279 CDS1 Protein similar to S. cerevisiae Cds1p; transposon mutation affects filamentous growth 4152 CEF3 Translation elongation factor 3 (EF-3); antigenic in human; predicted C-term nucleotide-binding active site, poly-Lys region; PROTEIN localizes to surface of yeast form, not hyphae; polystyrene adherence induced; EF-3 is fungal-specific 2886 CEK1 ERK-family protein kinase, required for wild-type yeast-hyphal switching, mating efficiency, and virulence in a mouse model; Cst20p-Hst7p-Cek1p-Cph1p MAPK pathway regulates mating, and invasive hyphal growth under some conditions 460 CEK2 MAP kinase required for wild-type efficiency of mating; component of the signal transduction pathway that regulates mating; ortholog of S. cerevisiae Fus3p; induced by Cph1p, pheromone; transposon mutation affects filamentous growth 5977 CEM1 Protein likely to be essential for growth, based on an insertional mutagenesis strategy; similar to S. cerevisiae Cem1p, which is an acyl carrier protein involved in fatty acid biosynthesis 2609 CET1 mRNA 5'-triphosphatase; large subunit of mRNA capping enzyme; positively regulates Ceg1p activity; functional homolog of S. cerevisiae Cet1p; Cet1p and Cgt1p form a 2:1 complex 1263 CFL1 Protein similar to ferric reductase Fre10p; possible functional homolog of S. cerevisiae Fre1p (reports differ); transcription is negatively regulated by Sfu1p, copper, amphotericin B, caspofungin; induced by ciclopirox olamine 701 CFL11 Predicted ORF in Assemblies 19, 20 and 21; similar to ferric reductase Fre10p; flucytosine repressed; possibly adherence-induced 1264 CFL2 Iron utilization protein; similar to an S. cerevisiae oxidoreductase, Ynr060Wp; regulated by Sfu1p, Nrg1p, Tup1p, Rim101p; alkaline, low iron, fluphenazine, ciclopirox olamine, flucytosine, induced; caspofungin, amphotericin B repressed 1932 CFL4 Similar to ferric reductase, C-terminal region; expression greater in low iron; transcription is negatively regulated by Sfu1p; ciclopirox olamine induced; shows colony morphology-related gene regulation by Ssn6p 1930 CFL5 Protein similar to ferric reductase Fre10p; expression greater in low iron; negatively regulated by Sfu1p; ciclopirox olamine, flucytosine induced; amphotericin B repressed; transcription is positively regulated by Tbf1p 2722 CGR1 Possible negative regulator of yeast-form growth; induced upon growth cessation at yeast-hyphal transition or during planktonic growth; physically interacts with Msi3p, an HSP70 family member; similar to rat anti-aging gene, SMP30 1261 CGT1 mRNA 5' guanylyltransferase; small subunit of mRNA capping enzyme; binds an RNA Pol II C-terminal domain peptide; Cet1p and Cgt1p form a 2:1 complex; functional homolog of S. cerevisiae Ceg1p 1996 CHA1 Protein similar to serine/threonine dehydratases, catabolic; negatively regulated by Rim101p; expression greater in low iron; regulated on white-opaque switching; filament induced; transposon mutation affects filamentous growth 896 CHK1 Histidine kinase involved in a two-component signaling pathway that regulates cell wall biosynthesis; disruption impairs hyphal development and decreases virulence in mouse intravenous (but not rat vaginal) infection 6851 CHL4 Protein described as having role in chromosome segregation; RNA abundance regulated by tyrosol and cell density 677 CHO1 Putative phosphatidylserine synthase; similar to S. cerevisiae Cho1p, which is involved in phosphatidylserine biosynthesis; transposon mutation affects filamentous growth; regulated by Nrg1p, Tup1p; no human or murine homolog 169 CHO2 Putative phosphatidyl-ethanolamine N-methyltransferase; fungal-specific (no human or murine homolog); amphotericin B repressed 3756 CHR1 Predicted DEAD-box ATP-dependent RNA helicase, functional homolog of S. cerevisiae Rok1p 5188 CHS1 Chitin synthase; essential; required for primary septum synthesis in yeast-form cells and hyphae; one of multiple chitin synthases; enzymatically activated by proteolytic processing; complements defects of S. cerevisiae chs1 or chs2 mutant 7298 CHS2 Chitin synthase; nonessential; required for wild-type chitin deposition in hyphae; transcription is regulated during dimorphic transition; Chs1p and Chs2p, but not Chs3p, are inhibited by the protoberberine HWY-289; fungal-specific 4937 CHS3 Major chitin synthase of yeast-form and hyphal cells; synthesizes short-chitin fibrils; Chs4p-activated; transcription induced at yeast-hyphal transition; Chs1p and Chs2p, but not Chs3p, are inhibited by the protoberberine HWY-289 7349 CHS4 Activator of Chs3p chitin synthase; required for wild-type wall chitin content, but not for hyphal growth; mutant resistant to Calcofluor white; prenylation and 2 transmembrane segments predicted; functional homolog of S. cerevisiae Chs4p 807 CHS5 Putative chitin biosynthesis protein; fungal-specific (no human or murine homolog); transcription decreases upon yeast-to-hyphal switch 5155 CHS6 Protein with tetratricopeptide repeats (TPRs); similar to S. cerevisiae Chs6p, which has role in localization of chitin synthase; decreased mRNA abundance observed in cyr1 homozygous mutant hyphae 2444 CHS7 Protein required for wild-type chitin synthase III activity; similar to (but not functional homolog of) S. cerevisiae Chs7p, which effects ER export of Chs3p; induced in homozygous cyr1 null mutant hyphae and ras1 yeast-form cells 5384 CHS8 Chitin synthase required for synthesis of long-chitin fibrils; nonessential; 8 or 9 membrane spanning regions; mRNA present in yeast and hyphae; induced during cell wall regeneration; fungal-specific (no human or murine homologs) 7517 CHT1 Chitinase; putative N-terminal catalytic domain; has secretory signal sequence; lacks S/T region and N-glycosylation motifs of Chs2p and Chs3p; alkaline downregulated; expression not detected in yeast-form or hyphal cells 3895 CHT2 Chitinase; putative N-terminal catalytic domain, GPI anchor, O-mannosylated region, signal peptide; 3 N-glycosylation motifs; downregulated in core caspofungin response; induced in yeast-form cells; Cyr1p-, Efg1p-, pH-regulated 7586 CHT3 Chitinase, major; functional homolog of S. cerevisiae Cts1p; 4 N-glycosylation motifs; possible O-mannosylated region; putative signal peptide; hyphal-repressed; farnesol upregulated in biofilm; regulated by Efg1p, Cyr1p, Ras1p 1515 CHT4 Chitinase; similar to S. cerevisiae sporulation-specific Cts2p; functionally complements A. gossypii cts2 mutant sporulation defect; homozygous null mutation causes no obvious defects; transcription decreases upon yeast-to-hyphal switch 124 CIC1 Predicted ORF in Assemblies 19, 20 and 21; transcription is upregulated in both intermediate and mature biofilms 113 CIP1 Protein with slight similarity to plant isoflavone reductase; transcription induced by cadmium (specifically, not by other heavy metals or heat shock), yeast-hyphal switch, oxidative stress (via Cap1p), or macrophage interaction 2839 CIRT4B Decreased transcription is observed in an azole-resistant strain that overexpresses CDR1 and CDR2 6053 CIS2 Putative role in regulation of biogenesis of the cell wall; upregulated in biofilm; Gcn4p-regulated 4393 CIT1 Protein described as citrate synthase; soluble protein in hyphae; biofilm induced; expression greater in high iron; upregulated upon phagocytosis; Hog1p-downregulated; regulated by Efg1p under yeast-form but not hyphal growth conditions 7652 CKA1 Putative alpha subunit (catalytic subunit) of protein kinase CK2; Cka1p and Cka2p have a common target with respect to fluconazole resistance; synthetically lethal with CKA2; flucytosine induced 3530 CKA2 Catalytic subunit (alpha-subunit) of protein kinase CK2; interaction with calcineurin pathway to affect fluconazole sensitivity; not essential for viability; synthetically lethal with CKA1; similar to S. cerevisiae Cka2p 2102 CKB1 Regulatory subunit of protein kinase CK2 (casein kinase II), beta subunit 4297 CKB2 Regulatory subunit of protein kinase CK2 (casein kinase II), beta' subunit 1282 CKS1 Predicted ORF in Assemblies 19, 20 and 21 4890 CLA4 S/T kinase of Ste20p family; required for wild-type filamentous growth and for wild-type organ colonization and virulence in mouse systemic infection; role in chlamydospore formation; functional homolog of S. cerevisiae Cla4p 1446 CLB2 B-type mitotic cyclin (cyclin-dependent protein kinase regulatory subunit); essential; required for wild-type mitotic exit; role in cell polarization; interacts with catalytic subunit Cdk1p 7186 CLB4 B-type mitotic cyclin; nonessential; negative regulator of pseudohyphal growth; dispensible for mitotic exit, cytokinesis; increased CLB4 transcript detected in fkh2 mutant; farnesol-upregulated in biofilm; reduced total RNA in clb4 mutant 6146 CLG1 Transcription is regulated upon yeast-hyphal switch 1960 CLN3 G1 cyclin; depletion causes abolished budding and hyphal growth defects; likely to be essential; farnesol regulated, upregulated in biofilm; functional in S. cerevisiae; similar to S. cerevisiae Cln3p, which is a G1-specific cyclin 4413 CMD1 Calmodulin; calmodulin inhibitors cause a defect in hyphal growth; not transcriptionally regulated by yeast-hyphal transition; mutation confers hypersensitivity to cytochalasin D and high concentrations of tunicamycin; gene has intron 5911 CMK1 Expression is regulated upon white-opaque switching; biochemically purified Ca2+/CaM-dependent kinase is soluble, cytosolic, monomeric, and serine-autophosphorylated 6033 CMP1 Catalytic subunit of calcineurin (Ca[2+]-calmodulin-regulated S/T protein phosphatase); required for wild-type virulence, resistance to high pH, Na(+), Li(+), Mn(2+), and fluconazole tolerance; micafungin is fungicidal to null mutant 4009 CNB1 Regulatory subunit of calcineurin B (Ca[2+]-calmodulin-regulated S/T protein phosphatase); required for wild-type resistance to fluconazole or to SDS; micafungin is fungicidal to null mutant 367 CNH1 Na+/H+ antiporter; required for wild-type growth, cell morphology, and virulence in a mouse model of systemic infection; not transcriptionally regulated by NaCl; fungal-specific (no human or murine homolog) 6052 CNS1 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to radicicol 4118 CNT Cation-coupled nucleoside transporter (H(+)/nucleoside symporter); CNT family; transports adenosine, uridine, inosine, guanosine, tubercidin; variant alleles encode high- and low-affinity isoforms; S or G at residue 328 affects specificity 953.1 COF1 Protein described as cofilin; macrophage-induced protein; protein detected by mass spec in exponential and stationary phase cultures 3400 COQ3 Protein described as having role in coenzyme Q biosynthesis; transcriptionally induced by interaction with macrophage 3008 COQ4 Protein described as having role in coenzyme Q biosynthesis; transcriptionally induced by interaction with macrophage 3577 COQ5 Protein described as methyltransferase of ubiquinone biosynthesis; regulated by Gcn4p; repressed in response to amino acid starvation (3-aminotriazole treatment); induced upon adherence to polystyrene 1416 COX11 Protein repressed during the mating process; transcription is regulated by Nrg1p; transcription is upregulated in both intermediate and mature biofilms 1467 COX13 Predicted ORF in Assemblies 19, 20 and 21; flucytosine induced; repressed by nitric oxide 3656 COX15 Transcription is regulated by Nrg1p and Tup1p; alkaline downregulated 2006.1 COX17 ORF predicted by Annotation Working Group; transcription is upregulated in both intermediate and mature biofilms 4967 COX19 Predicted ORF in Assemblies 19, 20 and 21; Plc1p-regulated 1471 COX4 Protein described as subunit IV of cytochrome c oxidase; transcription is regulated by Mig1p; macrophage/pseudohyphal-induced gene; macrophage-induced protein; repressed by nitric oxide: intron in 5'-UTR 4759 COX5 Protein described as cytochrome oxidase subunit V; has putative regulatory element, upstream CCAAT box; macrophage/pseudohyphal-induced; repressed by nitric oxide; intron in 5'-UTR 873.1 COX6 Flucytosine induced 227 COX7 Predicted ORF in Assemblies 19, 20 and 21; flucytosine induced; repressed by nitric oxide 5213.1 COX8 ORF Predicted by Annotation Working Group; flucytosine induced; caspofungin repressed 5213.2 COX9 Putative subunit VIIa of cytochrome c oxidase; flucytosine induced 4630 CPA1 Putative carbamoyl-phosphate synthase subunit; alkaline downregulated; transcription is upregulated in both intermediate and mature biofilms 3221 CPA2 Predicted ORF in Assemblies 19, 20 and 21; protein detected by mass spec in stationary phase cultures; transcription is upregulated in both intermediate and mature biofilms 4433 CPH1 Transcription factor required for mating and hyphal growth on solid media; with Efg1p required for host cytokine response; in filamentation pathway with Ess1p and Czf1p; regulates genes of galactose metabolism 1187 CPH2 Transcriptional activator of hyphal growth; Myc bHLH family: directly regulates Tec1p, which regulates hypha-specific genes; probably homodimeric, phosphorylated; enhances S. cerevisiae nitrogen starvation-induced pseudohyphal growth 4866 CPP1 MAPK phosphatase of the VH1 family; regulates Cst20p-Hst7p-Cek1p-Cph1p hyphal growth pathway; required for wild-type virulence in mouse systemic infection; C516 is active site Cys; antigenic in human thrush; more mRNA in yeast than hyphae 1552 CPR3 Protein described as a peptidyl-prolyl cis-trans isomerase; macrophage-induced protein; protein level decreased in stationary phase cultures 7654 CPR6 Predicted ORF in Assemblies 19, 20 and 21; macrophage/pseudohyphal-repressed; heavy metal (cadmium) stress-induced; heterozygous null mutant displays sensitivity to virgineone 1339 CPY1 Carboxypeptidase Y; transcriptionally regulated at yeast-hyphal transition or macrophage response; upregulated in the presence of human neutrophils; regulated by Gcn2p and Gcn4p; putative N-glycosylation 4674.1 CRD2 Metallothionein; role in adaptation to growth with high concentration of copper ions; basal transcription is cadmium-repressed; regulated by Ssn6p; complements copper sensitivity of an S. cerevisiae cup1 null mutant 2706 CRH11 Putative ortholog of S. cerevisiae Crh1p; predicted glycosyl hydrolase domain; similar to Csf4p, to antigenic Aspergillus fumigatus Aspf9; predicted Kex2p substrate; putative GPI-anchor; localizes to cell wall; caspofungin-induced 3966 CRH12 Putative cell wall protein, member of the CRH family; transcription is regulated by Nrg1p and Tup1p; alkaline upregulated by Rim101p; repressed during cell wall regeneration 3523 CRK1 Protein kinase of the Cdc2 kinase subfamily involved in hyphal development and virulence; promotes hyphal development independently of Cph1 and Efg1; functionally complements pheromone hypersensitivity of S. cerevisiae sgv1 mutant 3330 CRL1 Predicted GTPase of RHO family; CAAX motif geranylgeranylated; expression in S. cerevisiae causes dominant-negative inhibition of pheromone response 7483 CRM1 Functional homolog of S. cerevisiae Crm1p, which acts in protein nuclear export; predicted to be resistant to antifungal drug leptomycin B; partially suppresses signal transduction defects of S. cerevisiae ste20 mutant 4784 CRP1 Copper transporter of the plasma membrane; P1-type ATPase (CPx type); mediates Cu resistance; similar to proteins of Menkes and Wilson disease; copper-induced; Tbf1p-activated; suppresses Cu sensitivity of S. cerevisiae cup1 null mutant 7359 CRZ1 Putative transcription factor; similar to S. cerevisiae calcineurin-regulated transcription factor Crz1p; mutant is fluconazole hypersensitive; likely to act downstream of calcineurin; has C2H2 zinc fingers; not required for mouse virulence 2356 CRZ2 Putative transcription factor; zinc finger; similar to S. cerevisiae Crz1p; homozygous crz1, not crz2, null mutation suppresses fluconazole resistance of homozygous cka2 null (defective in CK2 kinase ); Rim101p-downregulated at pH 8 7114 CSA1 Surface antigen on elongating hyphae and buds; no obvious hyphal defects in mutant; strain variation in number of repeat domains; upregulated in filaments; alkaline upregulated by Rim101p; ciclopirox induced; Efg1p- and Cph1p-regulated 3117 CSA2 Predicted ORF in Assemblies 19, 20 and 21; downregulated by Rim101p at pH 8; regulated by Tsa1p, Tsa1Bp in minimal media at 37 deg; induced by ketoconazole and nitric oxide 6926 CSC25 Guanyl-nucleotide exchange factor; activator of Ras/adenylyl cyclase pathway; functional homolog of S. cerevisiae Cdc25p; transposon mutation affects filamentous growth 6163 CSE4 Centromere-associated protein; essential; 4 Cse4p-containing nucleosomes, each containing 2 Cse4p molecules, bind to each centromere; similar to CENP-A (centromeric histone H3 variant) proteins; Cse4p and Mif2p colocalize at centromeres 4477 CSH1 Member of aldo-keto reductase family, similar to aryl alcohol dehydrogenases; role in adhesion to fibronectin, cell surface hydrophobicity; regulated by temperature, growth phase, benomyl, macrophage interaction; azole resistance associated 3366 CSH3 Functional homolog of S. cerevisiae Shr3p, which is a chaperone specific for amino acid permeases; localized to ER; required for wild-type amino-acid responsive hyphal growth and for mouse systemic virulence; regulated by Gcn2p and Gcn4p 5232 CSI2 Protein essential for growth; transposon mutation affects filamentous growth 7208 CSK1 Putative mitogen-activated protein (MAP) kinase with an unknown role; null mutant produces wrinkled colonies; similar to S. cerevisiae Smk1p, which is a protein kinase required for sporulation 2883 CSO99 Protein of unknown function, not conserved in S. cerevisiae 2531 CSP37 Plasma membrane, hyphal cell wall protein; role in progression of murine systemic infection; predicted P-loop, divalent cation binding, N-glycosylation sites; expressed in yeast and hyphae; hyphal downregulated; lacks S. cerevisiae homolog 3794 CSR1 Putative zinc-finger transcription factor involved in zinc homeostasis; involved in negative regulation of biofilm matrix; similar to S. cerevisiae Zap1p; mutation affects filamentous growth; suppresses S. cerevisiae rok1 mutant inviability 4242 CST20 Protein kinase of Ste20p/p65PAK family, required for wild-type mating efficiency and virulence in a mouse model; Cst20p-Hst7p-Cek1p-Cph1p MAPK pathway regulates some hyphal growth; involved in Cdc42p growth regulation 3401 CTA1 Protein similar to S. cerevisiae Mos10p, which affects S. cerevisiae filamentous growth; activates transcription in 1-hybrid assay in S. cerevisiae; protein levels increase under weak acid stress; nonessential 6112 CTA2 Putative transcriptional activator, activates transcription in 1-hybrid assay in S. cerevisiae; downregulated by Efg1p; member of a family of telomere-proximal genes; transcription is positively regulated by Tbf1p 4054 CTA24 Putative transcriptional activator, downregulated by Efg1p; member of a family of telomere-proximal genes; transcription is upregulated in an RHE model of oral candidiasis 7680 CTA26 Putative transcriptional activator; downregulated by Efg1p; transcription is upregulated in an RHE model of oral candidiasis; member of a family of telomere-proximal genes 1166 CTA3 Protein similar to S. cerevisiae Ede1p, which is involved in endocytosis; activates transcription in 1-hybrid assay in S. cerevisiae 7374 CTA4 Predicted transcription factor involved in response to nitric oxide; downregulated upon adherence to polystyrene; induced by nitric oxide; transcriptionally activated by Mnl1p under weak acid stress 3102 CTA6 Predicted ORF in Assemblies 19, 20 and 21; activates transcription in 1-hybrid assay in S. cerevisiae; possibly spurious ORF (Annotation Working Group prediction) 4288 CTA7 Predicted zinc-finger protein of unknown function; activates transcription in 1-hybrid assay in S. cerevisiae; has similarity to S. cerevisiae Stb4p 4775 CTA8 Protein that activates transcription in 1-hybrid assay in S. cerevisiae; transcriptionally activated by Mnl1p under weak acid stress 3315 CTA9 Protein induced during the mating process; activates transcription in 1-hybrid assay in S. cerevisiae 1499 CTF1 Putative zinc-finger transcription factor, similar to A. nidulans FarA and FarB; activates genes required for fatty acid degradation; induced by oleate; null mutant displays carbon source utilization defects and slightly reduced virulence 3239 CTF18 Predicted ORF in Assemblies 19, 20 and 21; cell-cycle regulated periodic mRNA expression 3494 CTF5 Protein induced during the mating process; transcription is repressed in response to alpha pheromone in SpiderM medium 576 CTF8 Protein repressed during the mating process 7612 CTM1 Predicted ORF in Assemblies 19, 20 and 21; regulated by Gcn2p and Gcn4p; transcriptionally activated by Mnl1p under weak acid stress 4551 CTN1 Predicted carnitine acetyl transferase; required for growth on nonfermentable carbon sources but not for hyphal growth or virulence in mouse systemic model; transcription induced in macrophage; macrophage/pseudohyphal-repressed after 16 hr 2809 CTN3 Predicted peroxisomal carnitine acetyl transferase; Ura+ deletion strain has no obvious metabolic, hyphal, or virulence defects; transcription induced by macrophage engulfment, hyphal growth, starvation, or nonfermentable carbon sources 5870 CTP1 Predicted ORF in Assemblies 19, 20 and 21; flucytosine induced; amphotericin B repressed, caspofungin repressed 3646 CTR1 Copper transporter; probably multimeric; transcribed if copper limited; induced by Mac1p, macrophage interaction, alkaline pH via Rim101p; 17-beta-estradiol downregulated; complements S. cerevisiae ctr1 ctr3 copper transport mutant 4720 CTR2 Predicted ORF in Assemblies 19, 20 and 21; induced by nitric oxide; clade-associated gene expression 3940.1 CUP1 Metallothionein, involved in copper resistance; transcription is induced by copper 5001 CUP2 Protein not essential for viability; similar to S. cerevisiae Cup2p, which is a copper-binding transcription factor that activates transcription of metallothionein genes 5886 CUP5 Predicted ORF in Assemblies 19, 20 and 21; caspofungin repressed 6514 CUP9 Protein of unknown function, upregulated in clinical isolates from HIV+ patients with oral candidiasis; transcription reduced upon yeast-hyphal switch; ketoconazole-induced; Plc1p-regulated; shows colony morphology-related Ssn6p regulation 4719 CWH41 Processing alpha glucosidase I, involved in N-linked protein glycosylation and assembly of cell wall beta 1,6 glucan 3225 CWH43 Predicted ORF in Assemblies 19, 20 and 21; transcription is downregulated in both intermediate and mature biofilms 3682 CWH8 Putative dolichyl pyrophosphate (Dol-P-P) phosphatase; ketoconazole-induced; expression is increased in a fluconazole-resistant isolate; clade-associated gene expression 5849 CWT1 Putative transcription factor; mutant has cell wall defects; transcription increased at stationary phase; has predicted PAS domain and Zn(II) Cys(6)-type DNA-binding region; similar to S. cerevisiae Ypl133cp 5000 CYB2 Protein described as precursor protein of cytochrome b2; transcriptionally regulated by iron; expression greater in high iron; alkaline downregulated; shows colony morphology-related gene regulation by Ssn6p 7049 CYB5 Cytochrome b(5); not essential for viability; similar to S. cerevisiae Cyb5p; transcriptionally regulated by iron; expression greater in high iron; fluconazole-induced; shows colony morphology-related gene regulation by Ssn6p 1770 CYC1 Cytochrome c; complements defects of an S. cerevisiae cyc1 cyc7 double mutant; transcriptionally regulated by iron; expression greater in high iron; alkaline downregulated; repressed by nitric oxide 1957 CYC3 Cytochrome c heme lyase, mitochondrial; gene also encodes antigenic cell-wall protein; mRNA more abundant in filaments than yeast-form; induced on polystyrene adherence, interaction with macrophage; N-glycosylation, 2 heme-binding motifs 6472 CYP1 Peptidyl-propyl cis-trans isomerase (PPIase); activity is cyclosporin A sensitive; soluble protein in hyphae; biofilm induced, macrophage-induced protein; downregulated upon treatment of biofilm with farnesol 7421 CYP5 Protein described as a peptidyl-prolyl cis-trans isomerase; macrophage-downregulated protein level; protein level decreased in stationary phase cultures 5148 CYR1 Adenylyl cyclase; mutant lacks cAMP; required for mucosal or systemic infection in mice; hyphal growth defect of mutant is rescued by exogenous cAMP; role in macrophage sensitivity, apoptosis; in pathway downstream of Ras1p 6402 CYS3 Predicted enzyme of sulfur amino acid biosynthesis; upregulated in biofilm; alkaline upregulated; amphotericin B induced; possibly adherence-induced; induced by heavy metal (cadmium) stress, oxidative stress (via Cap1p); Hog1p regulated 4536 CYS4 Predicted enzyme of sulfur amino acid biosynthesis; antigenic in mouse; upregulated in biofilm; alkaline upregulated; macrophage/pseudohyphal-induced 3527 CYT1 Protein described as cytochrome c1; transcriptionally regulated by iron; expression greater in high iron; alkaline downregulated 4578 CYT2 Protein described as cytochrome c1 heme lyase; transcription is regulated by Nrg1p; transcriptionally regulated by iron; expression greater in high iron 3127 CZF1 Transcriptional regulator of white-opaque switching frequency; hyphal growth regulator; has C-terminal zinc finger and central Glu-rich region; expression in S. cerevisiae causes dominant-negative inhibition of pheromone response 2157 DAC1 N-acetylglucosamine-6-phosphate (GlcNAcP) deacetylase; enzyme of N-acetylglucosamine utilization; required for wild-type hyphal growth and virulence in mouse systemic infection; gene is GlcNAc-induced 4688 DAG7 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to toxic ergosterol analog; a-specific transcription; alpha-factor induced 4777 DAK2 Protein described as similar to dihydroxyacetone kinase; transcription is decreased upon yeast-hyphal switch; fluconazole-induced; caspofungin repressed; protein detected by mass spec in stationary phase cultures 5454 DAL1 Predicted ORF in Assemblies 19, 20 and 21; transcription is regulated by Nrg1p and Mig1p; macrophage/pseudohyphal-repressed 313 DAL4 Putative allantoin permease; fungal-specific (no human or murine homolog) 309 DAL5 Putative allantoate permease; nitrogen catabolite repressed gene, induced in absence of preferred N sources; gene regulation by nitrogen source requires Gat1p; fungal-specific (no human or murine homolog) 3208 DAL52 Putative allantoate permease; fungal-specific (no human or murine homolog); not essential for viability; similar to S. cerevisiae Dal5p 5023 DAL7 Putative allantoate permease; fungal-specific (no human or murine homolog); not essential for viability 5859 DAL8 Putative allantoate permease; fungal-specific (no human or murine homolog) 6956 DAL9 Putative allantoate permease; fungal-specific (no human or murine homolog) 3065 DAO1 Putative D-amino acid oxidase; transcription is regulated upon yeast-hyphal switch 3365 DAO2 Putative D-amino acid oxidase 489 DAP1 Protein similar to S. cerevisiae Dap1p, which is a protein related to mammalian membrane-associated progesterone receptors involved in response to DNA damage; induced in core stress response; Hog1p regulated; clade-associated expression 4322 DAP2 Protein described as dipeptidyl aminopeptidase; transcriptionally regulated during macrophage response 1223 DBF2 Essential serine/threonine protein kinase involved in mitotic spindle formation and cytokinesis; required for septum formation, exit from mitosis, and normal hyphal morphogenesis; virulence-group-correlated expression 5166 DBF4 Predicted ORF in Assemblies 19, 20 and 21; macrophage/pseudohyphal-repressed; cell-cycle regulated periodic mRNA expression; S. cerevisiae ortholog is not cell-cycle regulated 171 DBP2 Predicted ORF in Assemblies 19, 20 and 21; flucytosine induced; downregulated in core stress response 4870 DBP3 Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins 6902 DBP7 Predicted ORF in Assemblies 19, 20 and 21; transcription is upregulated in both intermediate and mature biofilms 6652 DBP8 Protein likely to be essential for growth, based on insertional mutagenesis; similar to S. cerevisiae Dbp8p, which is an ATP-dependent helicase involved in rRNA processing; oxidative stress-repressed via Cap1p; flucytosine repressed 3506 DBR1 Debranchase; homozygous mutant accumulates lariat intermediates of mRNA splicing 7083 DCC1 Predicted ORF in Assemblies 19, 20 and 21; cell-cycle regulated periodic mRNA expression 244 DCG1 Transcription is regulated by Nrg1p and Mig1p 815 DCK1 Putative guanine nucleotide exchange factor required for embedded filamentous growth; activates Rac1p; contains a DOCKER domain; similar to adjacent DCK2 and to S. cerevisiae Ylr422wp; regulated by Nrg1p 816 DCK2 Predicted ORF in Assemblies 19, 20 and 21; similar to S. cerevisiae Ylr422wp; transposon mutation affects filamentous growth; transcriptionally activated by Mnl1p under weak acid stress 1989 DCW1 Protein with predicted GPI modification; dfg5 dcw1 double mutant is inviable; not required for wild-type hyphal growth; increased mRNA abundance observed in cyr1 homozygous null mutant (yeast-form or hyphal); fungal-specific 245 DDC1 Transcription is induced during filamentous growth; regulated by Nrg1p, Tup1p 7258 DDI1 Predicted ORF in Assemblies 19, 20 and 21; macrophage/pseudohyphal-repressed 4082 DDR48 Immunogenic stress-associated protein; regulated by filamentous growth pathways; induced by benomyl, caspofungin, or in azole-resistant strain; Hog1p, farnesol, alkaline downregulated; similar to S. cerevisiae Ddr48p 6702 DED81 Putative tRNA-Asn synthetase; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 7561 DEF1 Protein required for filamentous growth and for escape from epithelial cells and dissemination in an RHE model; transcription induced in oral candidiasis clinical isolates; induced by fluconazole, high cell density; hyphally regulated 4392 DEM1 Predicted ORF in Assemblies 19, 20 and 21; alpha-factor induced 4048 DES1 Putative delta-4 sphingolipid desaturase 209 DFG10 Predicted ORF in Assemblies 19, 20 and 21 881 DFG16 Protein of the Rim101p pathway that regulates filamentation in response to alkaline pH; required for host tissue invasion during infection; similar to S. cerevisiae Dfg16p that acts in Rim101p processing 2075 DFG5 N-linked mannoprotein of cell wall and membrane; possible signal transducer; role in hyphal growth and HWP1 induction in alkaline pH; GPI modification predicted; dfg5 dcw1 double mutant is inviable; caspofungin-induced, fungal-specific 5142 DFR1 Dihydrofolate reductase; trimethoprim resistant; DHFR reduces 7,8-dihydrofolate to 5,4,7,8-tetrahydrofolate; binds NADPH; target of drugs that selectively inhibit the fungal enzyme rather than the human enzyme 6971 DIE2 Protein not essential for viability; similar to S. cerevisiae Die2p, which is dolichyl-phosphoglucose-dependent glucosyltransferase involved in protein N-glycosylation 5010 DIM1 Protein likely to be essential for growth, based on an insertional mutagenesis strategy; similar to S. cerevisiae Dim1p, which is an 18S rRNA dimethylase involved in rRNA modification and processing; induced upon biofilm formation 5106 DIP2 Protein similar to S. cerevisiae Dip2p, of small ribonucleoprotein complex; transposon mutation affects filamentous growth; physically interacts with TAP-tagged Nop1p; heterozygous null mutant exhibits resistance to parnafungin 2942 DIP5 Putative permease for dicarboxylic amino acids; mutation confers hypersensitivity to toxic ergosterol analog; transcriptionally induced upon phagocytosis by macrophage; Gcn4p-regulated; upregulated by Rim101p at pH 8 554 DIT2 Monooxygenase of the cytochrome P450 family involved in chlamydospore formation; produces N,N'-bisformyl dityrosine from N-formyltyrosine; transcription is regulated by Nrg1p, Mig1p, and Tup1p 991 DJP1 Similar to bacterial DnaJ; reported to have a role in peroxisome biogenesis; transcriptionally regulated by iron; expression greater in low iron; induced upon adherence to polystyrene 5805 DLD1 Putative D-lactate dehydrogenase; transcription is specific to white cell type; shows colony morphology-related gene regulation by Ssn6p; transcription is upregulated in both intermediate and mature biofilms 3760 DLH1 Functional homolog of S. cerevisiae Dmc1p, which is a meiosis-specific protein 1192 DNA2 Protein similar to S. cerevisiae Dna2p, which is a DNA replication factor involved in DNA repair; induced under hydroxyurea treatment 6987 DNM1 Putative protein of unknown function; ; transcription is upregulated in an RHE model of oral candidiasis; transcription is regulated by Nrg1p, Mig1p, and Tup1p 4829 DOA1 Protein with WD-repeats and a mellitin-like sequence, similar to S. cerevisiae Doa1p, which is involved in ubiquitin-mediated protein degradation 7207 DOA4 Protein not essential for viability; similar to S. cerevisiae Doa4p, which is ubiquitin hydrolase, involved in recycling ubiquitin from proteasome-bound ubiquitinated intermediates; oxidative stress-induced via Cap1p 3392 DOG1 Putative 2-deoxyglucose-6-phosphatase; haloacid dehalogenase hydrolase/phosphatase superfamily; similar to S. cerevisiae Dog1p, Dog2p, Hor1p, and Rhr2p; regulated by Nrg1p, Tup1p 3370 DOT4 Protein similar to ubiquitin C-terminal hydrolase; localizes to cell surface of hyphal cells, but not yeast-form cells; repressed upon high-level peroxide stress 5417 DOT5 Alkaline downregulated 2545 DOT6 Predicted ORF in Assemblies 19, 20 and 21; repressed upon high-level peroxide stress 7564 DPB2 Probable subunit of DNA polymerase II (DNA polymerase epsilon), similar to S. cerevisiae Dpb2p; essential for viability 5073 DPM1 Protein with similarity to S. cerevisiae Dpm1p, which is dolichol phosphate mannose synthase; filament induced; Tup1p-regulated 656 DPP1 Putative diacylglycerol pyrophosphate phosphatase of diacylglycerol production for phospholipid biosynthesis; downregulation correlates with clinical development of fluconazole resistance 1155 DPP2 Predicted ORF in Assemblies 19, 20 and 21; similar to S. cerevisiae pyrophosphate phosphatase Lpp1p; possible role in farnesol biosynthesis 6459 DPP3 Protein similar to S. cerevisiae pyrophosphate phosphatase Dpp1p; required for farnesol biosynthesis; downregulated in response to 17-beta-estradiol, ethynyl estradiol 2407 DPS1-1 Putative tRNA-Asp synthetase; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage; protein detected by mass spec in stationary phase cultures 2283 DQD1 Predicted ORF in Assemblies 19, 20 and 21; ketoconazole-repressed; macrophage-downregulated protein abundance 5083 DRG1 Member of the DRG family of GTP-binding proteins; involved in regulation of invasive filamentous growth 7635 DRS1 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to 5-fluorouracil (5-FU), tubercidin (7-deazaadenosine); transcription is positively regulated by Tbf1p; downregulated during core stress response 3629 DSE1 Predicted cell wall protein; transcription is decreased in mutant lacking ACE2; periodic mRNA expression, peak at cell-cycle M/G1 phase 2370 DSL1 Protein similar to S. cerevisiae Dsl1p, which is a member of the t-SNARE complex of the endoplasmic reticulum 297 DTD2 Predicted ORF in Assemblies 19, 20 and 21 4002 DUN1 Protein similar to S. cerevisiae Dun1p, which is a serine-threonine protein kinase involved in DNA damage cell-cycle checkpoint; induced under Cdc5p depletion 780 DUR1,2 Urea amidolyase, contains urea carboxylase and allophanate hydrolase activities needed to hydrolyze urea to CO2; required for utilization of urea as nitrogen source and for hyphal switch in macrophages; transcription is regulated by Nrg1p 6656 DUR3 Putative protein of unknown function, transcription is upregulated in clinical isolates from HIV+ patients with oral candidiasis; alkaline downregulated; amphotericin B induced; shows colony morphology-related gene regulation by Ssn6p 5677 DUR4 Putative urea permease; fungal-specific (no human or murine homolog) 7205 DUR7 Putative urea transporter; fungal-specific (no human or murine homolog) 3322 DUT1 dUTP pyrophosphatase; converts dUTP to dUMP and pyrophosphate; cell-cycle regulated if expressed in S. cerevisiae; upstream MluI and SCB transcription regulatory elements; induced by 17-beta-estradiol, ethynyl estradiol, macrophage 5999 DYN1 Dynein heavy chain; dynein is a motor protein that moves toward the microtubule minus end; required for wild-type yeast-form cell separation, spindle positioning, nuclear migration, hyphal growth; transcription is regulated by Mig1p 2660 EAF3 Subunit of the NuA4 histone acetyltransferase complex 396 EAF6 Subunit of the NuA4 histone acetyltransferase complex 497 EAF7 subunit of the NuA4 histone acetyltransferase complex 1401 EAP1 Cell wall adhesin required for cell-cell adhesion and biofilm formation; GPI anchored; Efg1p-regulated; suppresses polystyrene or cell adhesion, filamentation, invasive growth defects of S. cerevisiae flo8 or flo11 mutant 125 EBP1 NADPH oxidoreductase; interacts with phenolic substrates, such as 17beta-estradiol; possible role in response to estrogen; induced by oxidative and weak acid stress, nitric oxide, benomyl; activated by Cap1p, Mnl1p; no mammalian homolog 5816 EBP7 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to toxic ergosterol analog; oxidative stress-induced via Cap1p 3374 ECE1 Protein comprising eight 34-residue repeats; hyphal-specific expression increases with extent of elongation of the cell; regulated by Rfg1p, Nrg1p, Tup1p, Cph1p, Efg1p, Hog1p, farnesol, phagocytosis; may contribute to biofilm formation 6445 ECI1 Protein similar to S. cerevisiae Eci1p, which is involved in fatty acid oxidation; transposon mutation affects filamentous growth; expression is regulated upon white-opaque switching 5299 ECM1 Decreased mRNA abundance observed in cyr1 homozygous mutant hyphae; induced by heavy metal (cadmium) stress; Hog1p regulated 299 ECM14 Predicted ORF in Assemblies 19, 20 and 21 7436.1 ECM15 ORF Predicted by Annotation Working Group; caspofungin repressed 4099 ECM17 Predicted enzyme of sulfur amino acid biosynthesis; putative role in regulation of cell wall biogenesis; upregulated in biofilm; possibly adherence-induced; regulated by Tsa1p, Tsa1Bp under H2O2 stress; Gcn4p-regulated; Tbf1p-activated 6958 ECM18 Predicted ORF in Assemblies 19, 20 and 21 4887 ECM21 Protein not essential for viability; similar to S. cerevisiae Ecm21p (may have cell wall role); alkaline upregulated by Rim101p; fluconazole induced; caspofungin repressed; downregulated in azole-resistant strain overexpressing MDR1 2623 ECM22 Putative transcription factor with zinc cluster DNA-binding motif 4958 ECM25 Non-essential protein involved in cell morphogenesis; predicted ORF in Assemblies 19, 20 and 21 6773 ECM29 Protein similar to S. cerevisiae Ecm29p; transposon mutation affects filamentous growth 1563 ECM3 Predicted ORF in Assemblies 19, 20 and 21 3010.1 ECM33 Cell wall protein; putative GPI-anchor; mutants show cell-wall defects and reduced adhesion, host cell damage, and endocytosis; mutant infection is immunoprotectiive in murine model; fluconazole-induced; caspofungin repressed 4255 ECM331 GPI-anchored protein; mainly at plasma membrane, also at cell wall; caspofungin induced; Plc1p-regulated; repressed by Rim101p, Hog1p; colony morphology-related gene regulation by Ssn6p; induced in cyr1 homozygous null mutant yeast-form cel 1325 ECM38 Alkaline upregulated 5164 ECM39 Putative mannosyltransferase; similar to S. cerevisiae Ecm39p, which has a role in Calcofluor white resistance; predicted Kex2p substrate; has HKEXRF motif 2613 ECM4 Protein similar to S. cerevisiae Ecm4p; transcription is regulated by Nrg1p and Tup1p; induced in core stress response or in cyr1 or ras1 homozygous null mutant (yeast-form or hyphal cells); transposon mutation affects filamentous growth 6500 ECM42 Putative ornithine acetyltransferase; fungal-specific (no human or murine homolog); Gcn2p-, Gcn4p-regulated; clade-specific gene expression 5643 ECM7 Predicted ORF in Assemblies 19, 20 and 21 3838 EFB1 Translation elongation factor EF-1 beta; downregulated in the presence of human whole blood or polymorphonuclear cells; macrophage/pseudohyphal-induced; antigenic in mouse; functional homolog of S. cerevisiae Efb1p; farnesol-downregulated 610 EFG1 Transcriptional repressor; required for white-phase cell type; hyphal growth, metabolism, cell-wall gene regulator; roles in adhesion, virulence; Cph1p and Efg1p have role in host cytokine response; bHLH; binds E-box; T206 phosphorylated 5498 EFH1 Transcriptional activator; minor role in transcriptional regulation, compared to Efg1p; regulates filamentous growth, phenotypic switching; homodimerizes; has APSES domain and acidic region; EFG1 and EFH1 genetically interact 5788 EFT2 Elongation Factor 2 (eEF2); GTPase; essential; highly expressed; target of sordarin antifungals; antigenic in human, mouse; lacks site for regulatory phosphorylation by eEF2 kinase; GCN-regulated; complements S. cerevisiae eft1 eft2 mutant 1154 EGD1 Predicted ORF in Assemblies 19, 20 and 21; soluble protein in hyphae; biofilm induced; macrophage/pseudohyphal-induced; protein detected by mass spec in exponential and stationary phase cultures 5858 EGD2 Predicted ORF in Assemblies 19, 20 and 21; soluble protein in hyphae; macrophage/pseudohyphal-induced; protein level decreased in stationary phase cultures 3040 EHT1 Protein similar to S. cerevisiae Eht1p; transcription is induced in response to alpha pheromone in SpiderM medium 7626 EIF4E Putative translation initiation factor eIF4E; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage; intron in 5'-UTR 6849 ELC1 Transcription is regulated by Nrg1p and Mig1p; regulated by Gcn2p and Gcn4p 7332 ELF1 Protein required for wild-type morphology, growth; Walker A and B (ATP/GTP binding) motifs, ABC transporter consensus; expressed in hyphal, pseudohyphal, and yeast form, upregulated in biofilm; S. pombe homolog is ABC ATPase of mRNA export 1907 EMC9 Protein not essential for viability, induced during the mating process 731 EMP46 Protein similar to S. cerevisiae Emp46p; transcription is induced in response to alpha pheromone in SpiderM medium 6070 ENA2 Protein described as sodium transporter; transcription is upregulated in response to ciclopirox olamine; alkaline upregulated by Rim101p; repressed upon high-level peroxide stress; upregulated in oral candidiasis clinical isolates 5170 ENA21 Predicted ORF similar to S. cerevisiae sodium transporters Ena1p and Ena5p; Gcn4p-regulated; flucytosine, amphotericin B, or ketoconazole-induced; osmotic stress-induced; overlaps orf19.5170.1, which is annotated as a blocked reading frame 1711 END3 Regulated by Gcn4p; induced in response to amino acid starvation (3-aminotriazole treatment) 3066 ENG1 Endo-1,3-beta-glucanase required for cell separation after division, orthologous to S. cerevisiae Dse4p; caspofungin repressed; fungal-specific (no human or murine homolog); repressed in response to alpha pheromone in SpiderM medium 395 ENO1 Enolase (2-phospho-D-glycerate-hydrolyase), enzyme of glycolysis and gluconeogenesis; major cell-surface antigen; binds host plasmin and plasminogen; immunoprotective; phagocytosis, biofilm-regulated; farnesol-downregulated 5507 ENP1 Protein similar to S. cerevisiae Enp1p; transposon mutation affects filamentous growth; decreased expression in response to prostaglandins 6686 ENP2 Predicted ORF in Assemblies 19, 20 and 21; essential; S. cerevisiae ortholog is essential; heterozygous mutation confers resistance to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine) 1553 ENT3 Putative protein of unknown function, induced during the mating process; transcription is upregulated in an RHE model of oral candidiasis 7529 EPL1 Subunit of the NuA4 histone acetyltransferase complex 1047 ERB1 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine); hyphal repressed; macrophage repressed 3541 ERF1 Putative translation release factor 1, which interacts with stop codons and promotes release of nascent peptides from ribosomes 406 ERG1 Squalene epoxidase, catalyzes epoxidation of squalene to 2,3(S)-oxidosqualene in the ergosterol biosynthetic pathway; essential; target of allylamine antifungal drugs; uses NADH as a reducing cofactor, while S. cerevisiae Erg1p uses NADPH 1591 ERG10 Protein similar to acetyl-CoA acetyltransferase; role in ergosterol biosynthesis; soluble in hyphae; changes in protein abundance associated with azole resistance; fluconazole or ketoconazole induced; macrophage-downregulated protein 922 ERG11 Lanosterol 14-alpha-demethylase, member of cytochrome P450 family that functions in ergosterol biosynthesis; target of azole antifungals; may contribute to drug resistance; azole- or biofilm-induced; subject to hypoxic regulation 4809 ERG12 Predicted ORF in Assemblies 19, 20 and 21 7312 ERG13 Protein similar to S. cerevisiae Erg13p, which is involved in ergosterol biosynthesis; transposon mutation affects filamentous growth; amphotericin B, caspofungin repressed; detected by mass spec in exponential and stationary phase cultures 6026 ERG2 C-8 sterol isomerase; enzyme of ergosterol biosynthesis pathway; converts fecosterol to episterol; mutant is hypersensitive to multiple drugs; ketoconazole-induced 4491 ERG20 Putative farnesyl pyrophosphate synthetase involved in isoprenoid and sterol biosynthesis, based on similarity to S. cerevisiae Erg20p; likely to be essential for growth, based on an insertional mutagenesis strategy 1598 ERG24 C-14 sterol reductase, has a role in ergosterol biosynthesis; mutation confers increased sensitivity to dyclonine 3732 ERG25 Putative C-4 methyl sterol oxidase with role in C4-demethylation of ergosterol biosynthesis intermediates, based on similarity to S. cerevisiae Erg25p; fluconazole-induced; upregulated in biofilm and in azole-resistant strain 4631 ERG251 Predicted ORF in Assemblies 19, 20 and 21; ketoconazole-induced; amphotericin B, caspofungin repressed 2909 ERG26 C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; amphotericin B, caspofungin repressed 3240 ERG27 3-Keto sterol reductase of ergosterol biosynthesis; acts in C-4 sterol demethylation with Erg25p and Erg26p; possible drug target, essential for viability; functional homolog of S. cerevisiae Erg27p 767 ERG3 C-5 sterol desaturase; introduces C-5(6) double bond into episterol in ergosterol biosynthesis; clinically-isolated homozygous null mutants show azole resistance, defects in hyphal growth and virulence; Efg1p-repressed; fluconazole-induced 5379 ERG4 Protein described as similar to sterol C-24 reductase; shows Mob2p-dependent hyphal regulation; fluconazole-induced; caspofungin repressed 5178 ERG5 Putative C-22 sterol desaturase; fungal C-22 sterol desaturases are cytochrome P450 enzymes of ergosterol biosynthesis, catalyze formation of the C-22(23) double bond in the sterol side chain; transposon mutation affects filamentous growth 1631 ERG6 Delta(24)-sterol C-methyltransferase, converts zymosterol to fecosterol in ergosterol biosynthesis by methylating position C-24; mutation confers nystatin resistance; fluconazole-induced; transcription increased in azole-resistant strain 1570 ERG7 2,3-epoxysqualene-lanosterol cyclase (lanosterol synthase), catalyzes the conversion of 2,3-oxidosqualene to lanosterol in sterol biosynthesis; fluconazole-induced 4606 ERG8 Putative phosphomevalonate kinase; enzyme of the mevalonate pathway of isoprenoid biosynthesis; transcription is regulated by Nrg1p; possible drug target, not conserved in H. sapiens 3616 ERG9 Putative farnesyl-diphosphate farnesyl transferase (squalene synthase) involved in the sterol biosynthesis pathway; likely to be essential for growth; regulated by fluconazole and lovastatin; amphotericin B, caspofungin repressed 4871 ERO1 Protein described as similar to S. cerevisiae Ero1p, which has a role in formation of disulfide bonds in the endoplasmic reticulum; fluconazole-induced; transcriptionally activated by Mnl1p under weak acid stress 7409 ERV25 Transcription is induced upon filamentous growth 586 ERV46 Transcription is induced upon filamentous growth 5416 ESA1 Subunit of the NuA4 histone acetyltransferase complex 1445 ESC4 Protein similar to S. cerevisiae Esc4p, which represses transposition; transposon mutation affects filamentous growth 3356 ESP1 Predicted ORF in Assemblies 19, 20 and 21; mutation confers increased sensitivity to nocodazole; periodic mRNA expression, peak at cell-cycle S/G2 phase 5196 ESS1 Prolyl isomerase (parvulin class); essential; involved in yeast-hyphal switching, Cph1p pathway; has inflexible linker between WW and isomerase domains, unlike human homolog; functional homolog of S. cerevisiae Ess1p 4045 EST1 Telomerase subunit; allosteric activator of catalytic activity, but not required for catalytic activity; has TPR domain 5423 EST3 Telomerase subunit; required for telomere maintenance in vivo; separable roles in telomerase activity and processivity; not required for catalytic activity in vitro; related to mammalian Tpp1p 2952 EXG2 Protein similar to S. cerevisiae Exg2p, which is an exo-1,3-beta-glucosidase; predicted Kex2p substrate; induced during cell wall regeneration 3116 EXM2 Decreased transcription is observed upon fluphenazine treatment 926 EXO1 Predicted ORF in Assemblies 19, 20 and 21; cell-cycle regulated periodic mRNA expression 6512 EXO70 Predicted ORF in Assemblies 19, 20 and 21; induced during planktonic growth 7379 FAA2 Predicted acyl CoA synthetase; expression is regulated upon white-opaque switching; transcription is upregulated in both intermediate and mature biofilms 272 FAA21 Predicted acyl CoA synthetase; upregulated upon phagocytosis; transcription is regulated by Nrg1p and Mig1p 4114 FAA2-1 Predicted long chain fatty acid CoA ligase; upregulated upon phagocytosis; induced by nitric oxide in yhb1 mutant 7156 FAA2-3 Predicted acyl CoA synthetase 7592 FAA4 Predicted acyl CoA synthase 1513 FAB1 Phosphatidylinositol 3-phosphate 5-kinase; required for hyphal growth on solid media, and for wild-type vacuolar morphology and acidification; not required for wild-type virulence in mouse systemic infection or for adherence to HeLa cells 118 FAD2 Delta-12 fatty acid desaturase, involved in production of linoleic acid, which is a major component of membranes 4933 FAD3 Omega-3 fatty acid desaturase, involved in production of alpha-linolenic acid, which is a major component of membranes; caspofungin induced; Plc1p-regulated; shows colony morphology-related gene regulation by Ssn6p 2488 FAL1 Predicted ORF in Assemblies 19, 20 and 21 7105 FAR1 Protein involved in regulation of pheromone-mediated mating; repressed by A1p and Alpha2p in white-phase cells; null mutant shows no pheromone response in opaque cells; overexpression causes enhanced pheromone response and cell cycle arrest 979 FAS1 Beta subunit of fatty-acid synthase; multifunctional enzyme; fluconazole-induced; amphotericin B, caspofungin repressed; macrophage/pseudohyphal-induced; fungal-specific (no human or murine homolog) 5949 FAS2 Alpha subunit of fatty-acid synthase; required for virulence in mouse systemic infection and rat oropharyngeal infection models; regulated by Efg1p; fluconazole-induced; amphotericin B repressed 3653 FAT1 Predicted enzyme of sphingolipid biosynthesis; upregulated in biofilm 3801 FAV1 Protein with weak similarity to S. cerevisiae Fus2p; induced by alpha pheromone mating factor in MTLa/MTLa opaque cells 1120 FAV2 Induced by mating factor in MTLa/MTLa opaque cells; greater mRNA abundance observed in a cyr1 homozygous null mutant than in wild type; filament induced; regulated by Nrg1p, Rfg1p, Tup1p; possibly spurious ORF (AWG prediction) 1914 FAV3 Induced by mating factor in MTLa/MTLa opaque cells 4618 FBA1 Putative fructose-bisphosphate aldolase; enzyme of glycolysis; antigenic in murine or human infection; regulated on yeast-hyphal switch; induced by Efg1p, Gcn4p, Hog1p, biofilm growth, or fluconazole; phagocytosis-repressed; fungal-specific 6178 FBP1 Fructose-1,6-bisphosphatase, a key enzyme of gluconeogenesis; involved in the carbohydrate metabolism; regulated by Efg1p, Ssn6p; upregulated upon phagocytosis, effecting switch from glycolysis to gluconeogenesis in macrophage 4195.1 FCA1 Cytosine deaminase; enzyme of pyrimidine salvage; functional homolog of S. cerevisiae Fcy1p; mutation is associated with resistance to flucytosine (5-FC) in a clinical isolate; hyphal downregulated; gene has intron 6817 FCR1 Putative zinc cluster transcription factor; negative regulator of fluconazole, ketoconazole, brefeldin A resistance; transposon mutation affects filamentous growth; partially suppresses S. cerevisiae pdr1 pdr3 mutant fluconazole sensitivity 3193 FCR3 Transcriptional regulator of the bZip family; partially functionally complements the fluconazole sensitivity of an S. cerevisiae pdr1 pdr3 double mutant; probable ortholog of S. cerevisiae Yap3p 333 FCY2 Putative purine-cytosine permease of pyrimidine salvage; similar to S. cerevisiae Fcy2p; mutation associated with resistance to flucytosine in clinical isolates; transposon mutation affects filamentation; farnesol-upregulated in biofilm 1357 FCY21 High affinity, high capacity, hypoxanthine-adenine-guanine-cytosine/ H+ symporter; purine-cytosine permease of pyrimidine salvage; similar to S. cerevisiae Fcy2p; mutation confers resistance to 5-fluorocytosine (5-FC) 1832 FCY23 Putative transporter; Gcn4p-regulated; more similar to S. cerevisiae Tpn1p, which is a vitamin B6 transporter, than to purine-cytosine permeases 7331 FCY24 Putative transporter; more similar to S. cerevisiae Tpn1p, which is a vitamin B6 transporter, than to purine-cytosine permeases; transcription is regulated by Nrg1p 638 FDH1 Putative formate dehydrogenase, oxidizes formate to produce CO2; induced during macrophage infection; fluconazole-downregulated; Mig1p regulated; downregulated by Efg1p under yeast, not hyphal, growth conditions; predicted to be cytosolic 7600 FDH3 Putative protein of glycine catabolism; downregulated by Efg1p under yeast-form but not hyphal growth conditions; transcriptionally activated by Mnl1p under weak acid stress 908 FEN12 Predicted ORF in Assemblies 19, 20 and 21; amphotericin B, caspofungin repressed 6794 FESUR1 Protein described as ubiquinone reductase; transcriptionally induced by interaction with macrophage; alkaline downregulated; repressed by nitric oxide; clade-associated gene expression 4211 FET3 Multicopper oxidase; required for growth under low-iron conditions; null mutant shows decreased prostaglandin E2 production; functional homolog of S. cerevisiae Fet3p; ketoconazole, caspofungin, amphotericin B repressed 4213 FET31 Predicted ORF in Assemblies 19, 20 and 21; flucytosine induced; caspofungin repressed 943 FET33 Putative multicopper ferro-O2-oxidoreductase; downregulated in core caspofungin response; fungal-specific (no human or murine homolog) 4215 FET34 Protein similar to multicopper ferroxidase; expression greater in low iron and reduced in a fluconazole-resistant isolate; downregulated by Sfu1p, Hog1p; alkaline upregulated by Rim101p; ciclopirox olamine induced 1206 FET35 Protein with similarity to multicopper ferroxidase; transcriptionally activated in low iron conditions; transcription is repressed by Sfu1p and activated under weak acid stress by Mnl1p; merged with orf19.4215 in Assembly 20 4212 FET99 Protein of multicopper oxidase family; similar to S. cerevisiae Fet3p; does not functionally complement S. cerevisiae fet3 mutant growth under low-iron conditions; iron-repressed transcription; regulated by Tup1p, Rim101p 3791 FGR10 Putative asparaginase; lacks ortholog in S. cerevisiae; transposon mutation affects filamentous growth 5479 FGR12 Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth 562 FGR13 Protein encoded in retrotransposon Zorro3 with a potential zinc finger; lacks an ortholog in S. cerevisiae; transposon mutation affects filamentous growth; possibly spurious ORF (Annotation Working Group prediction) 559 FGR14 Protein encoded in retrotransposon Zorro3 with similarity to retroviral endonuclease-reverse transcriptase proteins; lacks an ortholog in S. cerevisiae; transposon mutation affects filamentous growth 2054 FGR15 Putative transcription factor with zinc finger DNA-binding motif; lacks an ortholog in S. cerevisiae; transposon mutation affects filamentous growth; caspofungin induced; mutation causes marginal increase in caspofungin sensitivity 2303 FGR16 Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth; fluconazole-downregulated 5729 FGR17 Putative DNA-binding transcription factor; has zinc cluster DNA-binding motif; lacks an ortholog in S. cerevisiae; transposon mutation affects filamentous growth 4067 FGR18 Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth; possibly spurious ORF (Annotation Working Group prediction) 7071 FGR2 Protein similar to phosphate transporters; transposon mutation affects filamentous growth; expression is regulated upon white-opaque switching 1586 FGR22 Putative phosphatidylinositol-specific phospholipase C (PI-PLC); predicted type 2 membrane protein; no S. cerevisiae ortholog; role in, and regulated by, filamentation; no mouse systemic virulence role; almost identical to orf19.5797 1616 FGR23 Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth; transcriptionally repressed by A1p and Alpha2p in white-phase cells, a-specific and induced by alpha factor 7275 FGR24 Protein encoded in retrotransposon Zorro2 with similarity to retroviral endonuclease-reverse transcriptase proteins; lacks an ortholog in S. cerevisiae; transposon mutation affects filamentous growth 6680 FGR27 Putative transcription factor with zinc cluster DNA-binding motif; lacks an ortholog in S. cerevisiae; transposon mutation affects filamentous growth 1596 FGR28 Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth; possibly spurious ORF (Annotation Working Group prediction) 5316 FGR29 Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth 3845 FGR3 Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth 6965 FGR30 Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth; removed from Assembly 20 593 FGR32 Protein described as similar to S. cerevisiae Swa2p; induced upon adherence to polystyrene; transposon mutation affects filamentous growth 7579 FGR34 Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth 3413 FGR37 Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth 4549 FGR38 Protein lacking an ortholog in S. cerevisiae; member of a family of related proteins; transposon mutation affects filamentous growth; macrophage-induced gene 679 FGR39 Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth; possibly spurious ORF (Annotation Working Group prediction) 4910 FGR41 Putative GPI-anchored protein; transposon mutation affects filamentous growth; possibly spurious ORF (Annotation Working Group prediction) 3209 FGR42 Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth 4786 FGR43 Protein lacking an S. cerevisiae ortholog; transposon mutation affects filamentous growth; transcriptionally activated by Mnl1p under weak acid stress; possible spurious ORF (Annotation Working Group prediction) 5967 FGR44 Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth 7557 FGR46 Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth 3429 FGR47 Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth 3884 FGR50 Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth; possibly spurious ORF (Annotation Working Group prediction) 156 FGR51 Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth 5315 FGR6 Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth; removed from Assembly 20 5191 FGR6-1 Protein lacking an ortholog in S. cerevisiae; member of a family encoded by FGR6-related genes in the RB2 repeat sequence; transposon mutation affects filamentous growth 1234 FGR6-10 Protein lacking an ortholog in S. cerevisiae; member of a family encoded by FGR6-related genes in the RB2 repeat sequence; transposon mutation affects filamentous growth 4712 FGR6-3 Protein lacking an ortholog in S. cerevisiae; member of a family encoded by FGR6-related genes in the RB2 repeat sequence; transposon mutation affects filamentous growth 3490 FGR6-4 Protein lacking an ortholog in S. cerevisiae; member of a family encoded by FGR6-related genes in the RB2 repeat sequence; transposon mutation affects filamentous growth 2236 FHL1 Protein with forkhead domain; similar to Fhl1p 138 FIG1 Probable ortholog of S. cerevisiae Fig1p, which is an integral membrane protein required for mating; role in thigmotropism; transcription is opaque-specific, a-specific, and activated by Cph1p or alpha pheromone 5389 FKH2 Forkhead transcription factor; morphogenesis regulator; required for wild-type hyphal transcription, cell separation, and for virulence in cell culture; mutant lacks true hyphae, is constitutively pseudohyphal; upregulated in RHE model 2501 FLC1 Protein involved in heme uptake; putative FAD transporter, similar to S. cerevisiae Flc1p; regulated by iron; macrophage-induced gene; mutant shows defect in filamentous growth 1813 FLC2 Protein involved in heme uptake; putative FAD transporter, similar to S. cerevisiae Flc2p 2198 FLC3 Protein involved in heme uptake; putative FAD transporter, similar to S. cerevisiae Flc3p 1093 FLO8 Transcription factor; required for wild-type hyphal formation; regulates hyphal gene expression; required for virulence in mouse systemic infection; binds Efg1p; binds Mss11p via LisH motif; has LUFS domain; ortholog of S. cerevisiae Flo8p 5404 FLO9 Protein repressed during the mating process 6577 FLU1 Multidrug efflux pump of the plasma membrane; member of the MDR family of the MFS (major facilitator superfamily) of transporters; preferred substrate may be mycophenolic acid; fungal-specific (no human or murine homolog) 1523 FMO1 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to toxic ergosterol analog, and to amphotericin B 857 FMO2 Predicted ORF in Assemblies 19, 20 and 21; expression regulated during planktonic growth 3422 FMP27 Predicted ORF in Assemblies 19, 20 and 21; fungal-specific (no human or murine homolog) 6489 FMP45 Protein induced during the mating process; mutation confers hypersensitivity to toxic ergosterol analog, and to amphotericin B; alkaline downregulated; repressed in response to alpha pheromone in SpiderM medium 4418 FMT1 Protein described as a methionyl-tRNA transformylase; induced upon adherence to polystyrene 579 FOL1 Putative dihydroneopterin aldolase (dihydro-6-hydroxymethylpterin pyrophosphokinase); fungal-specific (no human or murine homolog) 1288 FOX2 Predicted 3-hydroxyacyl-CoA epimerase, required for fatty acid beta-oxidation; upregulated upon phagocytosis; transcription is regulated by Mig1p and by white-opaque switching; transcriptional activation by oleate requires Ctf1p 1704 FOX3 Putative peroxisomal 3-oxoacyl CoA thiolase; expression is regulated upon white-opaque switching 3402 FPG1 Formamidopyrimidine DNA glycosylase, involved in repair of gamma-irradiated DNA 1415 FRE10 Major cell-surface ferric reductase under low-iron conditions; 7 transmembrane regions and a secretion signal predicted; repressed by Tup1p, Rim101p, Ssn6p, Hog1p, caspofungin; ciclopirox olamine induced; not required for filamentous growth 6140 FRE30 Protein with similarity to ferric reductases; downregulated in response to amphotericin B, estradiol, or ciclopirox olamine, and upregulated by interaction with macrophage; un-merged from orf19.6139 in a revision of Assembly 21 6139 FRE7 Protein similar to ferric reductase Fre10p; transcription is downregulated in response to treatment with ciclopirox olamine or 17-beta-estradiol; transcriptionally induced by alkaline conditions or interaction with macrophage 3538 FRE9 Protein similar to ferric reductase Fre10p; alkaline upregulated; ciclopirox olamine induced; induced by nitric oxide 5634 FRP1 Predicted ferric reductase; gene alkaline-induced directly by Rim101p; iron-chelation-induced by CCAAT-binding factor (with Hap43p); fluconazole-downregulated; ciclopirox olamine induced; colony morphology-related gene regulation by Ssn6p 7112 FRP2 Protein described as ferric reductase; alkaline upregulated by Rim101p; fluconazole-downregulated; upregulated in the presence of human neutrophils; possibly adherence-induced 1224 FRP3 Upregulated in the presence of human neutrophils; fluconazole-downregulated; repressed by nitric oxide 3440 FRP5 Predicted ORF in Assemblies 19, 20 and 21; flucytosine repressed 3441 FRP6 Transcription is regulated by Nrg1p and Tup1p; regulated by Ssn6p; upregulated in the presence of human neutrophils 2573 FRS1 Protein similar to the beta subunit of S. cerevisiae phenylalanyl-tRNA synthetase; possible role in early cell wall biosynthesis; translation-related genes are downregulated upon phagocytosis by murine macrophage 2960 FRS2 Putative tRNA-Phe synthetase; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 4802 FTH1 Protein not essential for viability; similar to S. cerevisiae Fth1p (putative high affinity iron transporter for intravacuolar stores of iron); repressed by Sfu1p, amphotericin B, caspofungin; induced by alkaline pH, ciclopirox olamine 3227 FTH2 Putative iron transporter; similar to S. cerevisiae Fth1p 7219 FTR1 High-affinity iron permease (ferric citrate, ferrioxamines E or B, transferrin); required for mouse virulence, low-iron growth; iron, amphotericin B, caspofungin, ciclopirox, Hog1p regulated; complements S. cerevisiae ftr1 iron transport 7231 FTR2 High-affinity iron permease; not required for mouse systemic virulence; regulated by iron level, ciclopirox olamine, amphotericin B, caspofungin; complements S. cerevisiae ftr1 iron transport defect; probably interacts with ferrous oxidase 543 FUM11 Protein described as fumarate hydratase; transcriptionally regulated by iron; expression greater in high iron; protein detected by mass spec in exponential and stationary phase cultures 6724 FUM12 Protein described as similar to fumarate hydratase, enzyme of citric acid cycle; fluconazole-downregulated; downregulated by Efg1p; transcriptionally regulated by iron; expression greater in high iron 5081 FUN12 Functional homolog of S. cerevisiae Fun12p translation initiation factor eIF5B; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 7451 FUN31 Putative PAS kinase involved in cell wall damage response; similar to S. cerevisiae Psk1p, which is a putative serine/threonine protein kinase; transcriptionally activated by Mnl1p under weak acid stress 2640 FUR1 Uracil phosphoribosyltransferase; enzyme of pyrimidine salvage; predicted tetrameric enzyme; mutations are associated with resistance to flucytosine (5-FC) in clinical isolates (clade I); macrophage-induced protein; flucytosine induced 360 FUR4 Predicted ORF in Assemblies 19, 20 and 21 1156 FUS1 Probable ortholog of S. cerevisiae Fus1p, which is a membrane protein required for mating; transcription is activated by Cph1p in mating type a cells, homozygous for the MTLa locus; alpha factor induced 1422 FZO1 Putative mitochondrial biogenesis protein; fungal-specific (no human or murine homolog) 7053 GAC1 Protein described as similar to regulatory subunit of serine/threonine phosphoprotein phosphatase 1; fluconazole-induced; caspofungin repressed; transcriptionally activated by Mnl1p under weak acid stress; regulated by Nrg1p, Tup1p 1153 GAD1 Protein described as glutamate decarboxylase; macrophage-downregulated gene; alkaline downregulated; amphotericin B induced; transcriptionally activated by Mnl1p under weak acid stress 3670 GAL1 Galactokinase; transcription regulated by galactose; transcription regulated by Mig1p and Tup1p; not required for systemic mouse virulence; farnesol-downregulated in biofilm; fluconazole-induced 3672 GAL10 UDP-glucose 4-epimerase, required for galactose utilization; mutant shows cell wall defects and increased filamentation; fluconazole-induced; protein detected by mass spec in stationary phase cultures 3674 GAL102 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to toxic ergosterol analog 5338 GAL4 Putative transcription factor with zinc cluster DNA-binding motif; ortholog of S. cerevisiae Gal4p, but is not involved in the regulation of galactose utilization genes; caspofungin repressed 3675 GAL7 Predicted ORF in Assemblies 19, 20 and 21; macrophage/pseudohyphal-repressed 4304 GAP1 General amino acid permease; antigenic in human, mouse; 10-12 transmembrane regions; regulated by nitrogen source; alkaline, GlcNAc, phagocytosis upregulated; not required for virulence in mouse systemic infection; fungal-specific 6993 GAP2 Protein similar to amino acid permeases; ketoconazole, flucytosine repressed; induced by histidine, and induction requires Ssy1p; regulated by Nrg1p, Tup1p; shows colony morphology-related gene regulation by Ssn6p 4456 GAP4 Putative amino acid permease; hyphal induced; regulated by Gcn2p and Gcn4p; shows colony morphology-related gene regulation by Ssn6p; detected at plasma membrane of yeast-form and germ tube by mass spectrometry 6659 GAP6 Putative general amino acid permease; Plc1p-regulated; Gcn4p-regulated; fungal-specific (no human or murine homolog) 1164 GAR1 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to tubercidin (7-deazaadenosine); macrophage/pseudohyphal-induced 1275 GAT1 Zinc finger transcriptional regulator of nitrogen utilization; required for nitrogen catabolite repression and utilization of isoleucine, tyrosine and tryptophan N sources; required for virulence in a mouse systemic infection model 4056 GAT2 Putative DNA-binding transcription factor; similar to S. cerevisiae Gat2p; transposon mutation affects filamentous growth 4899 GCA1 Predicted extracellular or plasma membrane-associated glucoamylase; promotes biofilm matrix formation; possible adhesin; gene is transcribed during rat oral infection; transcription is regulated by carbohydrates, pH, galactose 999 GCA2 Predicted extracellular glucoamylase, promotes biofilm matrix formation 481 GCD1 Putative translation initiation factor; transcription is regulated by Mig1p; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 4223 GCD11 Protein similar to S. cerevisiae Gcd11p, which is a subunit of translation initiation factor eIF2; likely to be essential for growth, based on an insertional mutagenesis strategy 6776 GCD2 Putative translation initiation factor; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 407 GCD6 Putative catalytic epsilon subunit of the translation initiation factor eIF2B, based on similarity to S. cerevisiae Gcd6p; genes encoding translation factors are downregulated upon phagocytosis by murine macrophage 825 GCD7 Protein described as a translation initiator; downregulated in the presence of human whole blood or polymorphonuclear (PMN) cells 400 GCF1 HMG box-containing mitochondrial (mt) protein; binds to mt DNA and to the HWP1 promoter; mutant phenotype and functional complementation of an S. cerevisiae abf2 mutation suggest a role in mt genome replication and maintenance 5328 GCN1 Protein not essential for viability; similar to S. cerevisiae Gcn1p, which is a regulator of the protein kinase Gcn2p involved in translation initiation 6913 GCN2 Translation initiation factor 2-alpha (eIF2alpha) kinase; has nonessential role in amino acid starvation response, in contrast to S. cerevisiae homolog; similar to S. cerevisiae Gcn2p 6060 GCN20 YEF3-subfamily ABC family protein, predicted not to be a transporter 6904 GCN3 Protein described as a translation initiator; downregulated in the presence of human whole blood or polymorphonuclear (PMN) cells 1358 GCN4 Transcriptional activator of general amino acid control response; required for Efg1p-dependent pseudohyphal filament induction by amino acid starvation but not by serum; upregulated in the presence of human whole blood or PMN cells 705 GCN5 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to 5-fluorouracil (5-FU) 387 GCR3 Functional homolog of S. cerevisiae Gcr3p, which acts in regulation of glycolytic genes; no intron predicted, in contrast to intron in S. cerevisiae GCR3 gene 5059 GCS1 Gamma-glutamylcysteine synthetase; enzyme of glutathione synthesis; similar to Hansenula polymorpha Gsh2p; induced on early/intermediate biofilm formation, in low iron, H2O2, Cd, or presence of human neutrophils; possibly adherence-induced 5519 GCV1 Protein described as T subunit of glycine decarboxylase; transcription is negatively regulated by Sfu1p 385 GCV2 Putative protein of glycine catabolism; downregulated by Efg1p; Hog1p-induced; upregulated by Rim101p at acid pH; transcription is activated in the presence of elevated CO2; protein detected by mass spec in stationary phase cultures 5006 GCV3 Predicted ORF in Assemblies 19, 20 and 21; protein level decreased in stationary phase cultures 6757 GCY1 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to toxic ergosterol analog; farnesol-downregulated; protein detected by mass spec in stationary phase cultures 7394 GDA1 Golgi membrane GDPase, required for wild-type O-mannosylation, not N-glycosylation; required for wild-type hyphal induction, cell wall, and cell surface charge; not required for HeLa cell adherence; functional homolog of S. cerevisiae Gda1p 744 GDB1 Putative glycogen debranching enzyme; expression is regulated upon white-opaque switching; regulated by Nrg1p, Tup1p 2192 GDH2 Putative NAD-specific glutamate dehydrogenase; fungal-specific (no human or murine homolog); transcription is regulated by Nrg1p, Mig1p, Tup1p, and Gcn4p 4716 GDH3 Protein described as similar to NADP-glutamate dehydrogenase; hyphal downregulated expression; transcription is regulated by Nrg1p, Plc1p; downregulated by Efg1p; upregulated by Rim101p at pH 8; ciclopirox olamine induced 1712 GEA2 Protein described as an ARF GTP/GDP exchange factor; transcriptionally regulated by iron; expression greater in low iron 3734 GEF2 Predicted ORF in Assemblies 19, 20 and 21 1618 GFA1 Glucosamine-6-phosphate synthase; enzyme of chitin/hexosamine biosynthesis; homotetrameric; inhibited by UDP-GlcNAc, FMDP, N-acyl peptide, kanosamine-6-P; functional homolog of S. cerevisiae Gfa1p; growth-phase regulated; catalytic Cys 2471 GIM5 Predicted ORF in Assemblies 19, 20 and 21; macrophage/pseudohyphal-repressed gene and macrophage-induced protein 658 GIN1 Protein involved in regulation of DNA-damage-induced filamentous growth; putative component of DNA replication checkpoint; ortholog of S. cerevisiae Mrc1p, an S-phase checkpoint protein 663 GIN4 Kinase involved in pseudohyphal-to-hyphal switch; phosphorylates Cdc11p on S395 (regulatory); autophosphorylates; necessary for septin ring within germ tube, but not for septin band at mother cell junction; role in cytokinesis 3182 GIS2 Transcriptionally regulated by iron; expression greater in high iron; transcription reduced upon yeast-hyphal switch; similar to proteins that bind nucleic acid 1979 GIT1 Putative glycerophosphoinositol permease; fungal-specific (no human or murine homolog); alkaline downregulated; transcription is specific to white cell type; caspofungin repressed; macrophage/pseudohyphal-repressed 1978 GIT2 Putative glycerophosphoinositol permease; fungal-specific (no human or murine homolog); transcription is repressed in response to alpha pheromone in SpiderM medium 1980 GIT4 Putative glycerophosphoinositol permease; fungal-specific (no human or murine homolog) 5622 GLC3 Protein described as similar to 1,4-glucan branching enzyme; fluconazole-induced; shows colony morphology-related gene regulation by Ssn6p; protein detected by mass spec in stationary phase cultures 6285 GLC7 Protein described as serine/threonine phosphatase; transcriptionally regulated by iron; expression greater in high iron; intron in 5'-UTR 2215 GLE1 Predicted ORF in Assemblies 19, 20 and 21; moderately induced at 42 deg 7434 GLG2 Protein described as self-glucosylating initiator of glycogen synthesis; expression is regulated upon white-opaque switching; hyphal-induced 734 GLK1 Putative glucokinase; transcription is regulated upon yeast-hyphal switch; transcriptionally regulated by Efg1p; fluconazole-induced; induced in core stress response; shows colony morphology-related gene regulation by Ssn6p 6116 GLK4 Protein described as a glucokinase; decreased expression in hyphae compared to yeast-form cells 646 GLN1 Protein described as similar to glutamate synthase; regulated by Tsa1p, Tsa1Bp under H2O2 stress conditions 3912 GLN3 GATA transcription factor involved in regulation of filamentous growth induced by nitrogen starvation; regulates transcription of Mep2p ammonium permease; regulated by Gcn2p and Gcn4p 7064 GLN4 Putative tRNA-Gln synthetase; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 6058 GLO1 Predicted ORF in Assemblies 19, 20 and 21; oxidative stress-induced via Cap1p 5445 GLO3 Protein not essential for viability; similar to S. cerevisiae Glo3p, which is a GTPase-activating protein for ADP-ribosylation factors 4147 GLR1 Glutathione reductase; transcriptionally regulated by Cap1p; upregulated in the presence of human neutrophils; oxidative stress-induced via Cap1p; overexpression correlates with multidrug resistance in a cap1 mutant, farnesol induced 6257 GLT1 Putative glutamate synthase; alkaline downregulated; transcription is downregulated in both intermediate and mature biofilms 986 GLY1 L-threonine aldolase; possibly tetrameric; complements the glycine auxotrophy of an S. cerevisiae shm1 null shm2 null gly1-1 triple mutant; macrophage/pseudohyphal-induced; the GLY1 locus has an RFLP and is triploid in strain SGY269 837 GNA1 Glucosamine-6-phosphate acetyltransferase; enzyme of UDP-GlcNAc biosynthesis; required for viability in absence of GlcNAc supplementation; required for persistent infection and wild-type virulence in mouse systemic infection 5024 GND1 Putative 6-phosphogluconate dehydrogenase; soluble protein in hyphae; farnesol-, macrophage-induced protein; antigenic in mouse; protein detected by mass spec in exponential and stationary phase cultures 1193 GNP1 Protein described as similar to asparagine and glutamine permease; fluconazole or caspofungin induced; transcription is regulated by Nrg1p, Mig1p, Tup1p, Gcn2p, Gcn4p, and alkaline regulated by Rim101p; fungal-specific 7565 GNP3 Putative high-affinity glutamine permease; fungal-specific (no human or murine homolog) 3818 GOA1 Protein required for respiratory growth, resistance to oxidants, chlamydospore formation, hyphal growth under some conditions, and virulence; relocalizes from the cytoplasm to the mitochondrion during oxidative or osmotic stress 1621 GPA2 G-protein alpha subunit; regulates filamentous growth; reports differ on a role in cAMP-mediated glucose signaling, cAMP-PKA pathway, MAP kinase cascade; Gpr1p C terminus binds Gpa2p; regulates HWP1 and ECE1 1756 GPD1 Protein similar to S. cerevisiae glycerol-3-phosphate dehydrogenase (enzyme of glycerol biosynthesis); biofilm-induced expression; regulated by Efg1p; regulated by Tsa1p, Tsa1Bp under H2O2 stress conditions 691 GPD2 Similar to glycerol 3-P dehydrogenases; regulated by Ssn6p (colony morphology-related), Nrg1p, Efg1p; induced upon osmotic and oxidative stress (via Hog1p), cell wall regeneration, macrophage/pseudohyphal growth, core stress response 7021 GPH1 Putative glycogen phosphorylase; gene regulated by Ssk1p, Mig1p, and Tup1p; fluconazole-induced; localizes to cell surface of hyphal cells, but not yeast-form cells; S. cerevisiae Gph1p is a stress-regulated protein of glycogen metabolism 6977 GPI1 Putative protein of GPI synthesis; expression is reduced in a fluconazole-resistant isolate 832 GPI13 Protein of major facilitator superfamily; has phosphodiesterase/nucleotide pyrophosphatase domain; similar to S. cerevisiae Gpi13p, which acts in GPI anchor biosynthesis 4064 GPI7 Protein involved in attachment of GPI-linked proteins to cell wall; member of major facilitator superfamily; phosphodiesterase/nucleotide pyrophosphatase domain; similar to S. cerevisiae Gpi7p 2799 GPI8 Protein likely to be essential for growth, based on an insertional mutagenesis strategy; similar to S. cerevisiae Gpi8p, which is a subunit of the GPI transamidase complex that adds GPI anchors to proteins 903 GPM1 Surface protein that binds host complement Factor H and FHL-1; phosphoglycerate mutase; antigenic in murine, human infection; biofilm-, fluconazole-, or amino acid starvation (3-aminotriazole treatment) induced, farnesol-downregulated 1067 GPM2 Protein described as phosphoglycerate mutase; decreased expression in hyphae compared to yeast-form cells; macrophage/pseudohyphal-repressed; induced by high levels of peroxide stress, farnesol-induced 1944 GPR1 Putative G-protein-coupled receptor of plasma membrane; required for wild-type hyphal growth; acts in cAMP-PKA pathway; reports differ on role in cAMP-mediated glucose signaling; Gpr1p C terminus binds Gpa2p; regulates HWP1 and ECE1 4063 GPT1 GABA/polyamine transporter; 9 to 11 membrane spanning segments; complements GABA uptake defect of an S. cerevisiae uga4 put4 gap1 triple mutant; complements growth of an S. cerevisiae spe1 mutant under polyamine limitation 87 GPX1 Predicted ORF in Assemblies 19, 20 and 21; peroxide-induced 85 GPX2 Similar to glutathione peroxidase; expression greater in high iron; alkaline upregulated by Rim101p; transcriptionally induced by alpha factor or interaction with macrophage; regulated by Efg1p; caspofungin repressed 3150 GRE2 Protein described as a reductase; transcription is regulated by Nrg1p and Tup1p; benomyl-induced; hyphal-induced; macrophage/pseudohyphal-repressed; expression greater in low iron; reported to be involved in osmotic stress response 4317 GRE3 Similar to D-xylose reductases; antigenic in murine systemic infection; soluble protein in hyphae; transcriptionally induced by macrophage interaction; transcriptionally induced by Mnl1p under weak acid stress, farnesol-induced 4781 GRP1 Protein similar to dihydroflavonol-4-reductases 4309 GRP2 Similar to S. cerevisiae Gre2p (methylglyoxal reductase); antigenic in human; regulation associated with azole resistance; induced in core stress response or by oxidative stress (via Cap1p), fluphenazine, benomyl, or fluconazole (long term) 3944 GRR1 Protein involved in the negative control of pseudohyphal growth; ortholog of S. cerevisiae Grr1p, which is an F-box protein component of the SCF ubiquitin-ligase complex required for cell cycle progression 437 GRS1 Putative tRNA-Gly synthetase; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage; protein detected by mass spec in stationary phase cultures 6510 GRX1 Protein described as glutaredoxin; transcriptionally regulated by iron; expression greater in low iron 2727 GRX3 Protein described as glutaredoxin; flucytosine induced; regulated by Gcn4p; repressed in response to amino acid starvation (3-aminotriazole treatment) 2929 GSC1 Subunit of beta-1,3-glucan synthase; essential; gsc1 allele determines resistance/sensitivity to echinocandin antifungals; 16 predicted membrane-spanning regions; mRNA abundance declines after yeast-to-hyphal transition; fungal-specific 3764 GSG1 Protein not essential for viability; similar to S. cerevisiae Gsg1p, which is a subunit of the TRAPP complex involved in targeting of ER-to-Golgi transport vesicles 6404 GSH2 Protein described as glutathione synthase; transcriptionally regulated by iron; expression greater in high iron; heavy metal (cadmium) stress-induced 2495 GSL1 Subunit of beta-1,3-glucan synthase; 10 predicted membrane-spanning regions; caspofungin induced; mRNA abundance declines after yeast-to-hyphal transition; similar to S. cerevisiae Fks3p; fungal-specific (no human or murine homolog) 3269 GSL2 Protein similar to beta-1,3-glucan synthase; 16 predicted membrane-spanning regions; transcription regulated by Nrg1p; very low gene expression in yeast-form and hyphal cells 5493 GSP1 Small RAN G-protein; essential; prenylation not predicted; overproduction complements viability of S. cerevisiae gsp1 mutant; macrophage/pseudohyphal-induced; not transcriptionally regulated during white-opaque or yeast-hyphal switching 3121 GST1 Predicted ORF in Assemblies 19, 20 and 21; upregulated in the presence of human neutrophils; expression is regulated upon white-opaque switching; increased transcription is observed upon benomyl treatment 2693 GST2 Increased transcription is observed upon benomyl treatment transcription and in populations of cells exposed to fluconazole over multiple generations; regulated by Nrg1p, Tup1p; induced by nitric oxide 720 GST3 Expression is regulated upon white-opaque switching; upregulated in the presence of human neutrophils; peroxide-induced; induced in response to alpha pheromone in SpiderM medium 3278 GSY1 Protein described as glycogen synthase; enzyme of glycogen metabolism; transcription downregulated upon yeast-hyphal switch and regulated by Efg1p; strong oxidative stress induced; shows colony morphology-related gene regulation by Ssn6p 6998 GTT1 Protein described as glutathione S-transferase; downregulated upon adherence to polystyrene; regulated upon white-opaque switching; induced in the presence of human neutrophils; oxidative stress-induced via Cap1p; regulated by Gcn2p, Gcn4p 6947 GTT11 Predicted ORF in Assemblies 19, 20 and 21; induced by nitric oxide 359 GTT12 Predicted ORF in Assemblies 19, 20 and 21 356 GTT13 Predicted ORF in Assemblies 19, 20 and 21; opaque-specific transcription; transcription is repressed in response to alpha pheromone in SpiderM medium 4813 GUA1 Predicted ORF in Assemblies 19, 20 and 21; soluble protein in hyphae; flucytosine induced; macrophage-downregulated protein abundance; protein level decreased in stationary phase cultures 1115 GUK1 Putative guanylate kinase; identified in extracts from biofilm and planktonic cells; protein level decreased in stationary phase cultures 4985 GUP1 Protein with role in glycerol uptake; functionally complements growth of S. cerevisiae gup1 mutant under salt stress 558 GUT1 Protein described as glycerol kinase; downregulated upon adherence to polystyrene; greater mRNA abundance observed in a cyr1 homozygous null mutant than in wild type 3133 GUT2 Predicted ORF in Assemblies 19, 20 and 21; Plc1p-regulated; transcription is upregulated in both intermediate and mature biofilms 3811 GYP1 Transcription is regulated by Nrg1p, Mig1p, and Tup1p 1244 GYP2 Predicted ORF in Assemblies 19, 20 and 21 6706 GYP7 Predicted ORF in Assemblies 19, 20 and 21; similar to S. cerevisiae Gyp7p (GTPase-activating protein for Ypt1p); caspofungin-induced 2842 GZF3 Predicted ORF in Assemblies 19, 20 and 21; oxidative stress-induced via Cap1p 2432 HAC1 Putative transcription factor involved in unfolded protein response and control of cell morphology; transcript undergoes atypical splicing at C terminus under ER stress; induced during the mating process; caspofungin induced 6249 HAK1 Putative potassium transporter; similar to Schwanniomyces occidentalis Hak1p; amphotericin B induced; transcriptionally induced upon phagocytosis by macrophage 99 HAL21 Putative phosphoadenosine-5'-phosphate (PAP) or 3'-phosphoadenosine 5'-phosphosulfate (PAPS) phosphatase; possible role in sulfur recycling; biofilm induced; similar to S. cerevisiae Met22p; predicted Kex2p substrate; fungal-specific 105 HAL22 Putative phosphoadenosine-5'-phosphate (PAP) or 3'-phosphoadenosine 5'-phosphosulfate (PAPS) phosphatase; possible role in sulfur recycling; induced upon biofilm formation 3190 HAL9 Protein with Zn(2)-Cys(6) binuclear cluster; gene in zinc cluster region of Chr. 5; transcriptionally activated by Mnl1p in weak acid; similar to S. cerevisiae Hal9p, which is a putative transcription factor involved in salt tolerance 1108 HAM1 Predicted ORF in Assemblies 19, 20 and 21; caspofungin repressed; regulated by Gcn2p and Gcn4p 1228 HAP2 CCAAT-binding factor regulates low-iron (chelation) induction of FRP1 transcription, and under these conditions CBF comprises Hap43p and probably Hap2p and Hap3p 4647 HAP3 Protein described as similar to CCAAT-binding transcription factor that regulates respiration; expression greater in low iron; transcription is opaque specific, alkaline upregulated, ciclopirox olamine induced 517 HAP31 Protein described as a transcription factor that regulates CYC1; transcriptionally regulated by iron; expression greater in high iron 740 HAP41 Predicted ORF in Assemblies 19, 20 and 21; not required for response to low iron; possibly spurious ORF (Annotation Working Group prediction); transcriptionally activated by Mnl1p under weak acid stress 1481 HAP42 Predicted ORF in Assemblies 19, 20 and 21 681 HAP43 CCAAT-binding factor (CBF)-dependent transcription factor required for iron-limitation response; similar to transcription factor AP-1; transcription is negatively regulated by Sfu1p; ciclopirox olamine induced 1973 HAP5 Component of CCAAT-binding transcription factor; roles in filamentous growth, low-iron (chelation) induction of FRP1 transcription; regulates genes with roles in respiratory growth; functional homolog of S. cerevisiae Hap5p 3962 HAS1 Functional homolog of S. cerevisiae Has1p, which is a nucleolar protein of the DEAD-box ATP-dependent RNA helicase family that is involved in biogenesis of the ribosome, particularly the small (40S) subunit; caspofungin-downregulated 6074 HBR1 Essential protein involved in regulation of MTL gene expression; hemoglobin-regulated inhibitor of white-opaque switching, which may affect survival in host; activator of MTLalpha1 and MTLalpha2; transcription is activated by hemoglobin 1078 HBR2 Uncharacterized protein, regulated by Gcn4p and hemoglobin; protein detected by mass spec in stationary phase cultures 6955 HBR3 Essential, uncharacterized protein; regulated by hemoglobin; S. cerevisiae ortholog is essential 2712 HCA4 Putative role in regulation of biogenesis of the cell wall; upregulated in biofilm 3396 HCH1 Protein not essential for viability; regulated by Gcn4p; induced in response to amino acid starvation (3-aminotriazole treatment); similar to S. cerevisiae Hch1p, which is a regulator of heat shock protein Hsp90p 4853 HCM1 Protein with forkhead domain; similar to S. cerevisiae Hcm1p 7613 HCR1 Putative translation initiation factor; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 2606 HDA1 Histone deacetylase; regulates frequency of white-to-opaque switching, but not opaque-to-white switching; greater expression in white cells than opaque cells; has conserved deacetylation motif; inhibited by trichostatin-A 2601 HEM1 Protein described as 5-aminolevulinate synthase; transcriptionally regulated by iron; caspofungin repressed; expression greater in high iron; regulated by Ssn6p; induced by nitric oxide 2803 HEM13 Coproporphyrinogen III oxidase; antigenic in human, mouse; localizes to yeast-form cell surface, not hyphae; soluble in hyphae; iron-regulated expression; macrophage-downregulated protein; not Rfg1p regulated, farnesol-induced 4747 HEM14 Putative protoporphyrinogen oxidase involved in heme biosynthesis; predicted Kex2p substrate; transcription is regulated by iron; mRNA levels are decreased in a yfh1 null mutant 1880 HEM15 Putative ferrochelatase involved in heme biosynthesis; transcription is not regulated by iron levels and is also not affected by a yfh1 null mutation 898 HEM2 Protein described as porphobilinogen synthase; transcriptionally regulated by iron; expression greater in high iron; protein level decreased in stationary phase cultures 1742 HEM3 Hydroxymethylbilane synthase (uroporphyrinogen I synthase); catalyzes conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in the heme biosynthetic pathway; transcription greater in high iron, CO2; alkaline downregulated 1744 HEM4 Protein described as uroporphyrinogen III synthase; transcriptionally regulated by iron; expression greater in high iron or elevated CO2; alkaline downregulated 6327 HET1 Putative sphingomyelin transfer protein 6673 HEX1 Beta-N-acetylhexosaminidase (beta-N-acetylglucosaminidase/chitobiase), highly glycosylated enzyme that is secreted to the periplasm and to the culture medium; required for full virulence; may have role in scavenging for carbon or nitrogen 1542 HEX3 Protein similar to S. cerevisiae Hex3p, which is involved in DNA damage response; transposon mutation affects filamentous growth 6028 HGC1 Hypha-specific G1 cyclin-related protein involved in regulation of hyphal morphogenesis; Cdc28p-Hgc1p maintains Cdc11p S394 phosphorylation during hyphal growth; required for virulence in mouse model; regulated by Nrg1p, Tup1p, farnesol 4587 HGH1 Transcription is regulated by Mig1p 4527 HGT1 High-affinity glucose transporter, member of major facilitator superfamily; transcription induced by progesterone and by drugs including chloramphenicol and benomyl; likely essential for growth, based on an insertional mutagenesis strategy 5753 HGT10 Glycerol permease involved in glycerol uptake; member of the major facilitator superfamily; induced by osmotic stress, at low glucose in rich media, during cell wall regeneration; 12 membrane spans 7094 HGT12 Glucose, fructose, mannose transporter; major facilitator superfamily; role in macrophage-induced hyphal growth; detected at germ tube plasma membrane by mass spectrometry; Snf3p-induced; 12 probable transmembrane segments 7093 HGT13 Predicted sugar transporter, involved in glycerol utilization; member of the major facilitator superfamily; 12 transmembrane; gene has intron; oxidative stress-induced via Cap1p; expressed in rich medium, 2% glucose 2633 HGT14 Putative glucose transporter of the major facilitator superfamily; the C. albicans glucose transporter family comprises 20 members; 12 probable membrane-spanning segments; expressed in rich medium with 2% glucose 6141 HGT16 Putative glucose transporter of the major facilitator superfamily; the C. albicans glucose transporter family comprises 20 members; 12 probable membrane-spanning segments; gene has intron; expressed in rich medium with 2% glucose 4682 HGT17 Putative glucose transporter of the major facilitator superfamily; the C. albicans glucose transporter family comprises 20 members; 12 probable membrane-spanning segments; induced at low (0.2%, compared to 2%) glucose in rich media 2425 HGT18 Putative glucose transporter of the major facilitator superfamily; the C. albicans glucose transporter family comprises 20 members; 12 probable membrane-spanning segments; expressed in rich medium with 2% glucose 5447 HGT19 Putative glucose/myo-inositol transporter of major facilitator superfamily; 12 transmembrane segments, extended N terminus; expressed in rich medium, 2% glucose; phagocytosis-induced; C. albicans glucose transporter family has 20 members 3668 HGT2 Putative glucose transporter of the major facilitator superfamily; the C. albicans glucose transporter family comprises 20 members; 12 probable membrane-spanning segments; expressed in rich medium with 2% glucose 1587 HGT20 Putative glucose transporter of the major facilitator superfamily; the C. albicans glucose transporter family comprises 20 members; 12 probable membrane-spanning segments; regulated by Nrg1p 4356 HGT3 Putative glucose transporter of the major facilitator superfamily; the C. albicans glucose transporter family comprises 20 members; 12 probable membrane-spanning segments, extended C terminus; expressed in rich medium with 2% glucose 6005 HGT5 Putative glucose transporter of the major facilitator superfamily; the C. albicans glucose transporter family comprises 20 members; 12 probable membrane-spanning segments, extended N terminus; expressed in rich medium with 2% glucose 2020 HGT6 Putative glucose transporter of major facilitator superfamily; 20 members of C. albicans glucose transporter family; 12 probable membrane-spanning segments; core stress response, fluconazole-induced; expressed in rich medium with 2% glucose 2023 HGT7 Putative glucose transporter, major facilitator superfamily; glucose-, fluconazole-, Snf3p-induced, expressed at high glucose; upregulated in biofilm; C. albicans glucose transporter family comprises 20 members; 12 TM regions predicted 2021 HGT8 Putative glucose transporter of the major facilitator superfamily; the C. albicans glucose transporter family comprises 20 members; 12 probable membrane-spanning segments; gene has intron; expressed in rich medium with 2% glucose 644 HGT9 Putative glucose transporter of the major facilitator superfamily; the C. albicans glucose transporter family comprises 20 members; 12 probable membrane-spanning segments; induced at low (0.2%, compared to 2%) glucose in rich media; intron 1059 HHF1 Putative histone H4; reduced mRNA in homozygous fkh2 null mutant; regulated by Efg1p; fluconazole induced; amphotericin B repressed; farnesol regulated; shows colony morphology-related gene regulation by Ssn6p 1854 HHF22 Putative histone H4; regulated by Efg1p; flucytosine, fluconazole-induced; amphotericin B, caspofungin repressed; shows colony morphology-related gene regulation by Ssn6p 5137.1 HHO1 Protein described at histone H1; farnesol regulated 6791 HHT1 Putative histone H3; reduced mRNA abundance detected in homozygous fkh2 null mutant; farnesol regulated 1853 HHT2 Protein described as histone H3; farnesol regulated 1061 HHT21 Putative histone H3; amphotericin B repressed; regulated by Efg1p; farnesol regulated 3195 HIP1 Alkaline upregulated; flucytosine induced; regulated by Plc1p, Gcn2p and Gcn4p; fungal-specific (no human or murine homolog) 4026 HIS1 ATP phosphoribosyl transferase; enzyme of histidine biosynthesis; fungal-specific (no human, murine homolog); upregulated in biofilm; acid upregulated/alkaline downregulated by Rim101p; regulated by Gcn2p, Gcn4p; strain CA9 is a his1 mutant 183 HIS3 Imidazoleglycerol-phosphate dehydratase, enzyme of histidine biosynthesis; functionally complements S. cerevisiae his3-1 mutation; hyphal-induced expression; regulated by Gcn2p and Gcn4p; fungal-specific (no human or murine homolog) 5639 HIS4 Multifunctional enzyme that catalyzes three steps of histidine biosynthesis, with phosphoribosyl-AMP cyclohydrolase, phosphoribosyl-ATP diphosphatase, and histidinol dehydrogenase activities; required for wild-type adhesion to human calls 4177 HIS5 Predicted ORF in Assemblies 19, 20 and 21; Gcn4p-regulated 5505 HIS7 Putative imidazole glycerol phosphate synthase; histidine biosynthesis; no human/murine homolog; transcription induced by histidine starvation; regulated by Gcn2p and Gcn4p; detected by mass spec in exponential/stationary phase culture 2723 HIT1 Protein not essential for viability; similar to S. cerevisiae Hit1p, which is required for growth at high temperature 7175 HLJ1 Protein repressed during the mating process 1031 HMG1 HMG-CoA reductase; enzyme of sterol pathway; inhibited by lovastatin; gene not transcriptionally regulated in response to lovastatin and fluconazole 7661 HMI1 ATP-dependent 3' - 5' helicase involved in maintenance of mitochondrial DNA; ortholog of S. cerevisiae Hmi1p 6645 HMO1 High mobility group-like protein; activates pseudohyphal growth when expressed in S. cerevisiae; decreased expression in hyphae compared to yeast-form cells; amphotericin B repressed 3291 HMT1 Major type I protein arginine methyltransferases (PRMT) involved in asymmetric dimethylation of arginine residues; involved in nuclear export of Npl3p 6073 HMX1 Heme oxygenase; acts in utilization of hemin iron; gene transcriptionally activated by heat, low iron, or hemin; negatively regulated by Efg1p; expression greater in low iron; upregulated by Rim101p at pH 8 2003 HNM1 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to toxic ergosterol analog; shows colony morphology-related gene regulation by Ssn6p; clade-associated gene expression 2587 HNM3 Predicted ORF in Assemblies 19, 20 and 21; flucytosine repressed 2946 HNM4 Putative choline permease; fungal-specific (no human or murine homolog) 2341 HNT1 Predicted ORF in Assemblies 19, 20 and 21; protein level decreased in stationary phase cultures 7419 HNT2 Predicted ORF in Assemblies 19, 20 and 21; induced upon low-level peroxide stress 3445 HOC1 Protein with similarity to mannosyltransferases; similar to S. cerevisiae Hoc1p and C. albicans Och1p 5664 HOF1 Protein not essential for viability; similar to S. cerevisiae Hof1p, which is a protein localized to the bud neck and required for cytokinesis; periodic mRNA expression, peak at cell-cycle G2/M phase 895 HOG1 MAP kinase of osmotic-, heavy metal-, and core stress response; role in regulation of glycerol, D-arabitol in response to stress; phosphorylated in response to H2O2 (Ssk1p-dependent) or NaCl; mutant induces protective mouse immune response 2991 HOL1 Predicted ORF in Assemblies 19, 20 and 21; transcription is regulated by Nrg1p; macrophage/pseudohyphal-repressed; transcription is induced in response to alpha pheromone in SpiderM medium 4546 HOL4 Protein described as an ion transporter; alkaline upregulated by Rim101p; Plc1p-regulated; caspofungin repressed 1559 HOM2 Putative aspartate-semialdehyde dehydrogenase; fungal-specific (no human or murine homolog); ketoconazole-repressed 1235 HOM3 Putative L-aspartate 4-P-transferase; fungal-specific (no human or murine homolog); regulated by Gcn2p and Gcn4p 6959 HOM32 Putative L-aspartate 4-P-transferase; fungal-specific (no human or murine homolog); removed from Assembly 20 2951 HOM6 Protein described as homoserine dehydrogenase; regulated by Gcn4p; induced in response to amino acid starvation (3-aminotriazole treatment); macrophage-induced protein; protein level decreased in stationary phase cultures 4411 HOS1 Histone deacetylase; similar to S. cerevisiae Hos1p; has conserved deacetylation motif; slightly greater expression in white cells than in opaque cells 5377 HOS2 Histone deacetylase; similar to S. cerevisiae Hos2p; has conserved deacetylation motif; slightly greater expression in white cells than in opaque cells 2772 HOS3 Histone deacetylase; similar to S. cerevisiae Hos3p; greater expression and longer mRNA in white cells, compared to opaque cells; has conserved deacetylation motif 6614 HPR5 Protein similar to S. cerevisiae Hpr5p DNA helicase of DNA repair; transposon mutation affects filamentous growth; clade-associated gene expression; removed from Assembly 20 5832 HPT1 Protein abundance is affected by URA3 expression in the CAI-4 strain background; protein level decreased in stationary phase cultures 233.1 HRT1 Protein similar to S. cerevisiae Hrt1p, which is a component of a nuclear ubiquitin-protein ligase complex involved in cell cycle control; induced under hydroxyurea treatment 4624 HRT2 Protein described as having a role in Ty3 transposition; decreased expression in hyphae compared to yeast-form cells; protein detected by mass spec in stationary phase cultures 4308 HSL1 Probable protein kinase, involved in determination of morphology during the cell cycle of both yeast-form cells and hyphae via regulation of Swe1p and Cdc28p; required for full virulence and kidney colonization in mouse systemic infection 1331 HSM3 Protein not essential for viability; similar to S. cerevisiae Hsm3p, which may be involved in DNA mismatch repair 6387 HSP104 Functional homolog of S. cerevisiae Hsp104p; has chaperone and prion propagation activity in S. cerevisiae; guanidine-insensitive; heat shock/stress induced; downregulated in biofilm upon treatment with farnesol; no human or murine homolog 3160 HSP12 Heat-shock protein; induced upon osmotic/oxidative/cadmium stress, fluphenazine treatment, low iron, CDR1 and CDR2 overexpression, or ssn6 or ssk1 homozygous null mutation; repressed by Hog1p, flucytosine, elevated CO2 4526 HSP30 Protein described as similar to heat shock protein; fluconazole-downregulated; amphotericin B induced 3664 HSP31 Protein repressed during the mating process 717 HSP60 Protein described as mitochondrial heat shock protein; soluble protein in hyphae; transcription is regulated by Nrg1p; transcriptionally regulated by iron; expression greater in high iron; heavy metal (cadmium) stress-induced 4980 HSP70 Putative hsp70 chaperone; role in sensitivity to beta-defensins; heat-shock, amphotericin B, Cd, ketoconazole-induced; farnesol-downregulated in biofilm; farnesol-induced; surface localized in yeast-form and hyphal cells; antigenic in host 882 HSP78 Protein described as a heat-shock protein; transcriptionally regulated by macrophage response; transcription is regulated by Nrg1p, Mig1p, Gcn2p, Gcn4p, Mnl1p; heavy metal (cadmium) stress-induced 6515 HSP90 Essential chaperone of Hsp90 family, activated by heat shock and stress; regulates several signal transduction pathways; localizes to surface of hyphae, but not yeast-form cells; mediates echinocandin resistance 2580 HST2 Predicted ORF in Assemblies 19, 20 and 21 7440 HST6 Functional homolog of S. cerevisiae Ste6p (a-pheromone transporter); required for mating of MTLa cells; ABC transporter related to mammalian P-glycoproteins; a-type specific, not regulated during white-opaque or yeast-hyphal switching 469 HST7 MAP kinase kinase, involved in signal transduction pathways for mating and hyphal growth; phosphorylates Cek1p; not required for wild-type virulence in mouse systemic infection; functional homolog of S. cerevisiae Ste7p 4592 HSX11 UDP-glucose:ceramide glucosyltransferase (glucosylceramide synthase [GCS], EC 2.4.1.80); enzyme of sphingolipid metabolism 6924 HTA1 Putative histone H2A; reduced mRNA abundance detected in homozygous fkh2 null mutant; amphotericin B repressed; farnesol regulated; RNA abundance regulated by tyrosol and cell density 1051 HTA2 Protein described as histone H2A; farnesol regulated; transcription is downregulated in both intermediate and mature biofilms 327 HTA3 Protein described as histone H2A; amphotericin B repressed; flucytosine induced; RNA abundance regulated by tyrosol and cell density 6925 HTB1 Putative histone H2B; induced upon adherence to polystyrene; amphotericin B or caspofungin repressed; flucytosine or fluconazole induced; regulated by Efg1p; slow growth, increased white-to opaque switching in ectopic expression strains 4051 HTS1 Putative tRNA-His synthetase; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage; protein detected by mass spec in stationary phase cultures 6803 HUT1 Predicted ORF in Assemblies 19, 20 and 21 1321 HWP1 Hyphal cell wall protein; covalently crosslinked to epithelial cells by host transglutaminase; opaque- and a-specific, alpha-factor induced; at MTLa side of conjugation tube; assessment of virulence role complicated by URA3 effects 3380 HWP2 Putative GPI-anchored protein; cell wall localization predicted; hyphal-specific expression; regulated by Efg1p, Tup1p; has similarity to Hwp1p, Ece2p, Rbt1p domains; predicted signal sequence and O-glycosylation 2154 HXK1 N-acetylglucosamine (GlcNAc) kinase; involved in GlcNAc utilization; required for wild-type hyphal growth and mouse virulence; gene expression is GlcNAc-induced; induced in response to alpha pheromone in SpiderM medium 542 HXK2 Protein described as hexokinase II; antigenic in human; downregulated in the presence of human neutrophils; regulated by Efg1p; fluconazole-induced; shows colony morphology-related gene regulation by Ssn6p 4384 HXT5 Protein described as a sugar transporter; transcription is upregulated in response to treatment with ciclopirox olamine; Snf3p-induced; alkaline downregulated; shows colony morphology-related gene regulation by Ssn6p 796 HYM1 Mo25 family domain protein of RAM cell wall integrity signaling network; role in cell separation, azole sensitivity; required for hyphal growth 4975 HYR1 Nonessential, GPI anchored, predicted cell wall protein; macrophage-induced protein; induced in hyphae; induction associated with azole resistance; regulated by Rfg1p, Efg1p, Nrg1p, Tup1p, Cyr1p 575 HYR3 Putative GPI-anchored protein of unknown function; similar to Hyr1p; transcriptionally regulated by iron; expression greater in high iron; clade-specific repeat variation 3279 HYR4 Putative GPI-anchored protein of unknown function; transcription is negatively regulated by Rim101p; constitutive expression independent of MTL or white-opaque status 3960 HYS2 Predicted ORF in Assemblies 19, 20 and 21; cell-cycle regulated periodic mRNA expression 5804 HYU1 Protein described as hydantoin utilization protein A; induced upon adherence to polystyrene; regulated by Gcn2p and Gcn4p 7667 IAH1 Protein similar to S. cerevisiae Iah1p, which is involved in acetate metabolism; mutation confers hypersensitivity to tunicamycin; transposon mutation affects filamentous growth 6844 ICL1 Isocitrate lyase; enzyme of glyoxylate cycle; required for wild-type virulence in murine systemic infection; no mammalian homolog; gene induced upon phagocytosis by macrophage; farnesol regulated; Pex5p-dependent peroxisomal localization 4826 IDH1 Predicted ORF in Assemblies 19, 20 and 21; soluble protein in hyphae; protein level decreased in stationary phase cultures 5791 IDH2 Protein described as isocitrate dehydrogenase subunit; transcription is upregulated in response to treatment with ciclopirox olamine; transcriptionally regulated by iron; expression greater in high iron 2775 IDI1 Predicted ORF in Assemblies 19, 20 and 21 5211 IDP1 Protein described as isocitrate dehydrogenase; transcriptionally induced by interaction with macrophage; alkaline upregulated 3733 IDP2 Putative isocitrate dehydrogenase; expression is regulated upon white-opaque switching; shows colony morphology-related gene regulation by Ssn6p; protein detected by mass spec in exponential and stationary phase cultures 7550 IFA14 Predicted ORF in Assemblies 19, 20 and 21; Plc1p-regulated; transcription is induced in response to alpha pheromone in SpiderM medium 5138 IFA21 Protein not essential for viability 4510 IFA4 Predicted ORF in Assemblies 19, 20 and 21; oxidative stress-induced via Cap1p 3746 IFC1 Oligopeptide transporter; transcriptionally induced upon phagocytosis by macrophage; macrophage/pseudohyphal-repressed after 16h; fluconazole-induced; virulence-group-correlated expression; fungal-specific (no human or murine homolog) 3749 IFC3 Oligopeptide transporter; transcriptionally induced upon phagocytosis by macrophage; induced by BSA or peptides; fluconazole-induced; upregulated by Rim101p at pH 8; virulence-group-correlated expression; no human or murine homolog 3311 IFD3 Transcription is regulated by Mig1p 1048 IFD6 Aldo-keto reductase family member; similar to aryl alcohol dehydrogenases, S. cerevisiae Ypl088wp; increased protein correlates with MDR1 overexpression (but not CDR1 or CDR2) in fluconazole-resistant clinical isolates; farnesol regulated 629 IFD7 Protein similar to aryl-alcohol dehydrogenases; regulated by Nrg1p, Tup1p; upregulation on benomyl treatment or fluconazole exposure over multiple generations; induction correlates with fluconazole resistance; removed from Assembly 20 769 IFE1 Protein not essential for viability; similar to S. cerevisiae Yal061wp, which is a putative polyol dehydrogenase 5288 IFE2 Protein described as an alcohol dehydrogenase; decreased expression in hyphae compared to yeast-form cells; Efg1p-regulated; fluconazole-induced; Hog1p-induced; increased expression in response to prostaglandins 5399 IFF11 Secreted protein required for normal cell wall structure and for virulence; member of the IFF family 4361 IFF3 Putative GPI-anchored protein of unknown function 7472 IFF4 Putative GPI-anchored protein; homozygous null mutant germ tubes show decreased adhesion to plastic substrate; not essential for viability 2879 IFF5 Putative GPI-anchored protein of unknown function 4072 IFF6 Putative GPI-anchored protein of unknown function; opaque-specific transcription; macrophage-induced gene 570 IFF8 Putative GPI-anchored protein of unknown function; decreased transcription is observed in an azole-resistant strain that overexpresses MDR1 465 IFF9 Transcriptionally regulated by iron; expression greater in low iron; similar to GPI-linked cell-wall proteins; similar to Hyr1p 944 IFG3 Putative D-amino acid oxidase 1639 IFH1 Predicted ORF in Assemblies 19, 20 and 21 4482 IFI3 Predicted ORF in Assemblies 19, 20 and 21; constitutive expression independent of MTL or white-opaque status 856 IFK2 Protein not essential for viability 5167 IFM1 Transcription is regulated by Nrg1p, Mig1p, and Tup1p 2176 IFM3 Predicted ORF in Assemblies 19, 20 and 21; Plc1p-regulated 1763 IFR1 Predicted ORF in Assemblies 19, 20 and 21; induced by nitric oxide 2396 IFR2 Increased transcription is observed upon benomyl treatment; transcription is upregulated in response to treatment with ciclopirox olamine, alpha pheromone; regulated by oxidative stress (via Cap1p) and osmotic stress (via Hog1p) 2568 IFU5 Predicted membrane protein; estradiol-induced; increased transcription is associated with CDR1 and CDR2 overexpression or fluphenazine treatment; gene has putative drug-responsive regulatory site; similar to S. cerevisiae Wwm1p 5760 IHD1 Putative GPI-anchored protein of unknown function; alkaline upregulated; greater transcription in hyphal form than yeast form; regulated by Nrg1p, Rfg1p, Tup1p; regulated by Tsa1p, Tsa1Bp in minimal media at 37; not essential for viability 6021 IHD2 Transcriptionally regulated by iron and by yeast-hyphal switching; expression greater in low iron 2138 ILS1 Protein similar to isoleucyl-tRNA synthetase, the target of drugs including the cyclic beta-amino acid icofungipen/PLD-118/BAY-10-8888 and mupirocin; detected by mass spec in exponential and stationary phase cultures 5480 ILV1 Protein described as threonine dehydratase; regulated by Gcn4p and Gcn2p; induced in response to amino acid starvation (3-aminotriazole treatment); protein detected by mass spec in both exponential and stationary phase cultures 1613 ILV2 Protein described as acetolactate synthase; regulated by Gcn4p; induced in response to amino acid starvation (3-aminotriazole treatment); protein detected by mass spec in stationary phase cultures 4040 ILV3 Putative dihydroxyacid dehydratase; fungal-specific (no human or murine homolog); upregulated in biofilm; S. cerevisiae ortholog is Gcn4p regulated; repressed by nitric oxide; macrophage-induced protein; farnesol-downregulated 88 ILV5 Protein described as ketol-acid reductoisomerase; antigenic during human or murine infection; regulated by Gcn4p; amino acid starvation (3-aminotriazole) induced; biofilm induced; macrophage-downregulated protein; no human or murine homolog 4650 ILV6 Putative regulatory subunit of acetolacetate synthase ; fungal-specific (no human or murine homolog); alkaline upregulated; regulated by Gcn2p and Gcn4p 2395 IME2 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to amphotericin B 18 IMH3 Inosine monophosphate (IMP) dehydrogenase; enzyme of GMP biosynthesis; target of mycophenolic acid and mizoribine monophosphate; antigenic during human or murine infection; soluble protein in hyphae; downregulated in core stress response 603 IMP4 Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins 2832 INN1 Protein with similarity to S. cerevisiae Inn1p, which is an essential protein of the contractile actomyosin ring required for ingression of the plasma membrane into the bud neck during cytokinesis; contains a C2 membrane targeting domain 7585 INO1 Inositol-1-phosphate synthase; enzyme of inositol biosynthesis; antigenic in human; repressed by farnesol (in biofilm) or caspofungin; regulated during planktonic growth; upstream inositol/choline regulatory element; glycosylation predicted 7539 INO2 Transcriptional activator that may be involved in regulation of ribosomal protein genes; forms a heterodimer with Ino4p; related to S. cerevisiae Ino2p 837.1 INO4 Transcriptional activator that may be involved in regulation of ribosomal protein genes; forms a heterodimer with Ino2p; related to S. cerevisiae Ino4p; gene has intron 1373 INP51 Putative phosphatidylinositol-4,5-bisphosphate phosphatase; involved in maintenance of phosphoinositide levels; affects hyphal growth, virulence, cell integrity; interacts with Irs4p 4257 INT1 Integrin-like protein; role in morphogenesis, adhesion, and mouse cecal colonization and systemic virulence; similar to S. cerevisiae Bud4p (has role in bud site selection); structurally similar to alpha-subunit of human leukocyte integrins 1439 IPK1 Predicted ORF in Assemblies 19, 20 and 21 1377 IPK2 Predicted ORF in Assemblies 19, 20 and 21; moderately induced at 42 deg 3474 IPL1 Predicted ORF in Assemblies 19, 20 and 21; induced during planktonic growth 3590 IPP1 Protein described as inorganic pyrophosphatase; antigenic in human, mouse; soluble protein in hyphae; macrophage-induced protein; protein detected by mass spec in exponential and stationary phase cultures 4769 IPT1 Inositol phosphoryl transferase, involved in sphingolipid biosynthesis; catalyzes the synthesis of the most abundant sphingolipid, mannose-(inositol-P)2-ceramide, M(IP)2C, from MIPC; required for wild-type membrane localization of Cdr1p 6536 IQG1 Component of actomyosin ring at bud neck; cell-cycle regulated serine phosphorylation at CDK sites regulates association with formins Bni1p and Bnr1p, Iqg1p degradation, and ring disassembly; mutation causes severe cytokinetic defects 5219 IRA2 Predicted ORF in Assemblies 19, 20 and 21 1715 IRO1 Putative transcription factor; role in iron utilization, pathogenesis; both IRO1 and adjacent URA3 are mutated in strain CAI4; suppresses S. cerevisiae aft1 mutant low-iron growth defect; hyphal-induced; reports differ about iron regulation 7232 IRR1 Predicted ORF in Assemblies 19, 20 and 21; cell-cycle regulated periodic mRNA expression 6953 IRS4 Protein with roles in cell wall integrity, systemic (but not oral) murine infection, adherence, hyphal growth, and agar-embedded filamentous growth; antigenic in human infection; similar to S. cerevisiae Irs4p 5521 ISA1 Reported to have possible role in iron-sulfur cluster biogenesis or cytoplasm-to-mitochondrion iron transport; alkaline downregulated; transcriptionally regulated by iron; expression greater in high iron 6629 ISC1 Putative phospholipase C, possible neutral sphingomyelinase; not essential for viability 3355 ISN1 Putative inosine 5'-monophosphate 5'-nucleotidase; fungal-specific (no human or murine homolog) 2792 IST2 Predicted ORF in Assemblies 19, 20 and 21 6548 ISU1 Protein with similarity to NifU; possible role in iron-sulfur cluster biogenesis; transcriptionally regulated by iron; expression greater in low iron; transcription is upregulated in both intermediate and mature biofilms 7401 ISW2 Protein required for chlamydospore formation, not essential for viability; repressed upon high-level peroxide stress; similar to S. cerevisiae Isw2p, which is an ATPase involved in chromatin remodeling 6685 ISY1 Predicted ORF in Assemblies 19, 20 and 21; mutation confers resistance to 5-fluorocytosine (5-FC) 3526 ITR1 Inositol transporter required for uptake of exogenous inositol; major facilitator superfamily; 12 probable transmembrane motifs; expressed in rich medium with 2% glucose; fluconazole, caspofungin downregulated 3592 JEM1 Functional homolog of S. cerevisiae Jem1p, which acts with Scj1p and Kar2p (BiP) in protein folding and ER-associated degradation of misfolded proteins, and also has a role in karyogamy; has J domain and 4 tetratricopeptide repeats 7447 JEN1 Lactate transporter; transcriptionally induced by lactic acid, activated by Cat8p; alkaline downregulated by Rim101p; localizes to plasma membrane; similar to S. cerevisiae Jen1p 5307 JEN2 Protein described as carboxylic acid transporter; induced by Rgt1p; transcription is upregulated in both intermediate and mature biofilms 4746 JIP5 Protein not essential for viability; downregulated during core stress response 4155 KAP114 Protein similar to S. cerevisiae Kap114p, which is involved in protein nuclear import; cdc73 kap114 double transposon mutation affects filamentous growth; possibly spurious ORF (by Annotation Working Group); removed from Assembly 20 7177 KAP120 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to cytochalasin D 2013 KAR2 Similar to chaperones of Hsp70p family; transcriptionally regulated by iron; expression greater in high iron; protein detected by mass spec in exponential and stationary phase cultures 564 KAR3 Kinesin-like microtubule motor protein; required for nuclear fusion during mating; C-terminal motor domain; not essential for viability; homozygous null has high-frequency white-opaque switching phenotype 3736 KAR4 Protein similar to S. cerevisiae Kar4p, which has a role in karyogamy; transcription is opaque-specific, a-specific, and induced by alpha factor 103 KAR5 Protein of unknown function; induced by alpha factor 5011 KAR9 Protein similar to S. cerevisiae Kar9p, which has role in mitotic spindle positioning; nonessential; localizes to bud tip, bud neck, hyphal tip; wild-type localization requires actin and microtubule cytoskeleton; induced by alpha factor 6092 KEL1 Protein containing a Kelch repeat domain, similar to S. cerevisiae Kel1p; not required for adherence to buccal epithelial cells or virulence in mouse systemic infection; null mutant colonies exhibit slightly decreased filamentation ratio 4969 KEM1 5'-->3' exoribonuclease; required for wild-type filamentous growth; not essential for viability; functionally complements S. cerevisiae kem1 mutant slow growth & mating and partially complements invasive growth & pseudohyphal growth 4755 KEX2 Subtilisin-like protease (proprotein convertase), processes aspartyl proteinase Sap2p; required for hyphal growth and wild-type virulence in mouse systemic infection; functional homolog of S. cerevisiae Kex2p, which processes alpha-factor 6165 KGD1 Protein described as 2-oxoglutarate dehydrogenase; regulated by Efg1p under yeast-form but not hyphal growth conditions; transcription is upregulated in an RHE model of oral candidiasis; detected by mass spec in stationary phase cultures 6126 KGD2 Protein described as dihydrolipoamide S-succinyltransferase; transcriptionally regulated by iron; expression greater in high iron 191 KIC1 Member of the GCK-III subfamily of eukaryotic Ste20p kinases; in RAM cell wall integrity signaling network; role in cell separation, azole sensitivity; required for hyphal growth; constitutive expression is MTL, white-opaque independent 7510 KIN2 Putative protein of with similarity to S. cerevisiae Kin2p, transcription is positively regulated by Tbf1; predicted ORF in Assemblies 19, 20 and 21 5325 KIN3 Protein similar to S. cerevisiae Kin3p; induced under Cdc5p depletion; shows Mob2p-dependent hyphal regulation 712 KIP1 Non-essential kinesin from the bipolar (Kinesis-5) family; involved in formation of the mitotic spindle 1747 KIP2 Protein similar to S. cerevisiae Kip2p; transcription is repressed in response to alpha pheromone in SpiderM medium; periodic mRNA expression, peak at cell-cycle G2/M phase 5265 KIP4 Transposon mutation affects filamentous growth; filament induced; shows Mob2p-dependent hyphal regulation; regulated by Nrg1p, Tup1p 4084 KIS1 Scaffold protein of Snf1p complex; similar to S. cerevisiae Gal83p and Sip2p, with regions of similarity to Sip1p (ASC and KIS domain); interacts with Snf4p 4997 KIS2 Scaffold protein of Snf1p complex; similar to S. cerevisiae Gal83p and Sip2p; interacts with Snf4p; interaction with Snf1p complex is regulated by carbon source, decreased on ethanol; N-terminal myristoylation; Hog1p-downregulated 4979 KNS1 Protein not essential for viability; similar to S. cerevisiae Kns1p, which is a protein kinase 418 KOG1 Protein likely to be essential for growth, based on an insertional mutagenesis strategy; heterozygous null mutant displays sensitivity to rapamycin 4377 KRE1 Predicted GPI-anchor, role in 1,6-beta-D-glucan biosynthesis; production in S. cerevisiae increases glucan content and complements killer toxin sensitivity of kre1 mutant; possible N-linked glycosylation at Asn109; caspofungin induced 2183 KRE30 YEF3-subfamily ABC family protein, predicted not to be a transporter; downregulated during core stress response; mutation confers hypersensitivity to amphotericin B 290 KRE5 Predicted UDP-glucose:glycoprotein glucosyltransferase; required for wild-type 1,6-beta-D-glucan biosynthesis, hyphal growth, and virulence in mouse IV infection; production in S. cerevisiae partially complements defects of a kre5 mutant 7363 KRE6 Protein of beta-1,6-glucan synthesis; essential; type II membrane protein; N-glycosylation sites; change in mRNA length, but not mRNA abundance, at yeast-hyphal transition; alkaline upregulated by Rim101p; induced on cell wall regeneration 942 KRE62 Protein described as subunit of glucan synthase; macrophage-induced gene 5861 KRE9 Protein of beta-1,6-glucan biosynthesis; required for serum-induced hyphal growth; required for efficient utilization of galactose and for growth on glucose; similar to S. cerevisiae Kre9p and Knh1p; O-glycosylated by Pmt1p 661 KRR1 Decreased transcription is observed upon benomyl treatment or in an azole-resistant strain that overexpresses MDR1; induced upon biofilm formation 6749 KRS1 Putative tRNA-Lys synthetase; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophages; protein detected by mass spec in stationary phase cultures 4432 KSP1 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to amphotericin B 6131 KSR1 3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis 2385 KTI12 Protein similar to S. cerevisiae Kti12p, which associates with Elongator complex; has a role in resistance to killer toxin; predicted Kex2p substrate 4494 KTR2 Protein with similarity to S. cerevisiae Ktr2p, which is a mannosyltransferase; transcription is elevated in chk1, nik1, and sln1 homozygous null mutants; fungal-specific (no human or murine homolog) 4475 KTR4 Protein with similarity to mannosyltransferases; induced during cell wall regeneration; fungal-specific (no human or murine homolog) 2774 LAB5 Predicted ORF in Assemblies 19, 20 and 21 3249 LAG1 Predicted ORF in Assemblies 19, 20 and 21; amphotericin B repressed 539 LAP3 Protein described as an aminopeptidase; transcription is positively regulated by Sfu1p; transcription is repressed in response to alpha pheromone in SpiderM medium; clade-associated gene expression; virulence-group-correlated expression 6671 LAP4 Protein similar to aminopeptidase I; mutation confers hypersensitivity to amphotericin B; transcriptionally regulated during macrophage response 1628 LAP41 Protein not essential for viability; similar to S. cerevisiae Lap4p, which is a vacuolar aminopeptidase; protein detected by mass spec in exponential and stationary phase cultures 4120 LAS1 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU); macrophage-induced gene 6561 LAT1 Protein described as dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex 5027 LCB2 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to aureobasidin A 5257 LCB4 Putative sphingosine kinase; expression is Tac1p-regulated 6486 LDG3 Predicted ORF in Assemblies 19, 20 and 21; induced upon biofilm formation 1260 LEA1 Protein similar to S. cerevisiae Lea1p; transcription is induced in response to alpha pheromone in SpiderM medium 3542 LEM3 Predicted ORF in Assemblies 19, 20 and 21; mutation causes increased resistance to miltefosine 7498 LEU1 Protein described as 3-isopropylmalate dehydratase; antigenic in human; decreased expression in hyphae compared to yeast-form cells; alkaline downregulated; upregulated in the presence of human whole blood or polymorphonuclear (PMN) cells 7080 LEU2 Isopropyl malate dehydrogenase; enzyme of leucine biosynthesis; upregulated in the presence of human whole blood or polymorphonuclear (PMN) cells; protein level decreased in stationary phase cultures 4225 LEU3 Predicted zinc-finger protein; has similarity to S. cerevisiae Leu3p, which is involved in regulation of branched-chain amino acid biosynthesis genes; alkaline upregulated; transcriptionally activated by Mnl1p under weak acid stress 6086 LEU4 Putative 2-isopropylmalalate synthase; regulated by Nrg1p, Mig1p, Tup1p, Gcn4p; upregulated in the presence of human whole blood or polymorphonuclear (PMN) cells; macrophage/pseudohyphal-repressed after 16h; fungal-specific 1375 LEU42 Putative alpha-isopropylmalate synthase; fungal-specific (no human/murine homolog); upregulated in the presence of human blood or polymorphonuclear cells; regulated by Gcn2p and Gcn4p; detected by mass spec in stationary phase cultures 2117 LEU5 Predicted ORF in Assemblies 19, 20 and 21; transcription is upregulated in both intermediate and mature biofilms 6511 LIG1 tRNA ligase; functional homolog of S. cerevisiae Trl1p; fungal-specific (no human or murine homolog) 5798 LIG4 DNA ligase; mRNA detected in yeast-form and pseudohyphal cells, induced upon hyphal induction; suppresses S. cerevisiae ime1-1 mutant IME2 transcription defect; required for wild-type filamentous growth and wild-type pathogenesis 4821 LIP1 Secreted lipase, member of a lipase gene family whose members are expressed differentially in response to carbon source and during infection; may have a role in nutrition and/or in creating an acidic microenvironment 4822 LIP10 Secreted lipase, member of a lipase gene family whose members are expressed differentially in response to carbon source and during infection; may have a role in nutrition and/or in creating an acidic microenvironment 4804 LIP2 Secreted lipase; member of a differentially expressed lipase gene family; expressed in alimentary tract, but not oral tissue, during mouse oral infection; may have a role in nutrition and/or in creating an acidic microenvironment 4856 LIP3 Secreted lipase, member of a lipase gene family whose members are expressed differentially in response to carbon source and during infection; may have a role in nutrition and/or in creating an acidic microenvironment 2133 LIP4 Secreted lipase, member of a differentially expressed lipase gene family with possible roles in nutrition and/or in creating an acidic microenvironment; expressed more strongly during mucosal infections than during systemic infections 5179 LIP5 Secreted lipase, member of differentially expressed lipase gene family with possible roles in nutrition and acidic microenvironment; LIP5 and LIP8 expressed at all stages of mucosal and systemic infection; affects filamentous growth 4823 LIP6 Secreted lipase, member of family of lipase genes expressed differentially in response to carbon source and during infection; may have a role in nutrition and/or in creating an acidic microenvironment; induced on adherence to polystyrene 7320 LIP7 Probable lipase, part of a gene family whose members are differentially expressed during infection; lacks a signal sequence for secretion, unlike other family members; may have a role in nutrition or in creating an acidic microenvironment 1345 LIP8 Secreted lipase, member of a differentially expressed lipase gene family with possible roles in nutrition and/or in creating an acidic microenvironment; LIP5 and LIP8 are expressed at all stages of both mucosal and systemic infection 5172 LIP9 Secreted lipase, member of a lipase gene family whose members are expressed differentially in response to carbon source and during infection; may have a role in nutrition and/or in creating an acidic microenvironment 992 LKH1 Protein repressed during the mating process; Hog1p-induced 6127 LPD1 Putative dihydrolipoamide dehydrogenase; soluble protein in hyphae; antigenic during human oral infection and murine systemic infection; macrophage-induced protein 771 LPG20 Protein of aldo-keto reductase family; nonessential; similar to aryl alcohol dehydrogenases, S. cerevisiae Ypl088wp, A. tumefaciens MocA; osmotic stress-induced, correlates with overexpression of MDR1 in fluconazole-resistant isolate 6544 LPI9 Predicted ORF in Assemblies 19, 20 and 21 6018 LRO1 Predicted ORF in Assemblies 19, 20 and 21; nonessential; similar to S. cerevisiae Lro1p acyltransferase 3358 LSC1 Protein described as succinate-CoA ligase subunit; transcriptionally regulated by iron; expression greater in high iron; fluconazole-induced 1860 LSC2 Protein described as beta subunit of succinate-CoA ligase; transcription regulated by Mig1p and Tup1p; transcriptionally regulated by iron; expression greater in high iron; filament induced 7509.2 LSM6 ORF Predicted by Annotation Working Group; flucytosine induced 3149 LSP1 Predicted ORF in Assemblies 19, 20 and 21; caspofungin repressed; biofilm induced; fungal-specific (no human or murine homolog); protein detected by mass spec in exponential and stationary phase cultures 2238 LTE1 Protein similar to S. cerevisiae Lte1p; transcription is repressed in response to alpha pheromone in SpiderM medium 5104 LTP1 Putative protein phosphatase of the PTP family (tyrosine-specific), similar to S. cerevisiae Ltp1p 7650 LTV1 Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins 651 LYP1 Predicted ORF in Assemblies 19, 20 and 21; amphotericin B induced; flucytosine repressed 1789.1 LYS1 Saccharopine dehydrogenase (biosynthetic); enzyme of alpha-aminoadipate lysine biosynthesis pathway; functionally complements S. cerevisiae lys1 mutation; fungal-specific (no human or murine homolog) 2525 LYS12 Protein described as mitochondrial homoisocitrate dehydrogenase; clade-associated gene expression; protein level decreased in stationary phase cultures 5380 LYS144 Putative transcription factor with zinc cluster DNA-binding motif; has similarity to S. cerevisiae Lys14p, which is a transcription factor involved in the regulation of lysine biosynthesis genes 2970 LYS2 Large subunit of heterodimeric alpha-aminoadipate reductase; enzyme of lysine biosynthesis; contains predicted binding sites for AMP and alpha-aminoadipate; feedback inhibited by lysine or thialysine; regulated by Gcn2p and Gcn4p 772 LYS21 Putative homocitrate synthase of lysine biosynthesis; expression is increased in a fluconazole-resistant isolate; shows colony morphology-related gene regulation by Ssn6p; ketoconazole-repressed; regulated by Gcn2p and Gcn4p 4506 LYS22 Putative homocitrate synthase; fungal-specific (no human or murine homolog); repressed by nitric oxide; protein level decreased in stationary phase cultures 3846 LYS4 Protein described as homoaconitase; regulated by Gcn4p, Gcn2p; induced in response to amino acid starvation (3-aminotriazole treatment); upregulated in the presence of human whole blood or polymorphonuclear (PMN) cells 6304 LYS5 Phosphopantetheinyl transferase; enzyme of lysine biosynthesis; modifies, and thereby activates, Lys2p alpha-aminoadipate reductase; functional homolog of S. cerevisiae Lys5p 7448 LYS9 Putative enzyme of lysine biosynthesis; soluble protein in hyphae; amphotericin B repressed; Gcn4p-regulated; shows colony morphology-related gene regulation by Ssn6p 7068 MAC1 Transcriptional regulator of CTR1, which encodes a copper transporter; activates CTR1 transcription under low-copper conditions; ectopic expression causes copper-sensitive stimulation of filamentation in S. cerevisiae 1040 MAD2 Protein required for the spindle assembly checkpoint of the cell cycle; necessary for survival in host cell macrophages and for virulence in a mouse model of systemic candidiasis 3419 MAE1 Malic enzyme, mitochondrial; transcription regulated by Mig1p and Tup1p; shows colony morphology-related gene regulation by Ssn6p 2173 MAF1 Protein described as affecting nucleocytoplasmic transport and synthesis of RNA Polymerase III; decreased expression in hyphae compared to yeast-form cells; caspofungin repressed 5500 MAK16 Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins 5912 MAK21 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to tubercidin (7-deazaadenosine) 4548 MAK32 Downregulated upon adherence to polystyrene 3540 MAK5 Predicted ORF in Assemblies 19, 20 and 21; oxidative stress-repressed via Cap1p; decreased expression in response to prostaglandins 7668 MAL2 Alpha-glucosidase that hydrolyzes sucrose; required for sucrose utilization; transcriptionally regulated by Suc1p; expression induced by maltose, repressed by glucose; transposon mutation affects filamentous growth; upregulated in RHE model 3981 MAL31 Putative protein of unknown function, transcription is upregulated in clinical isolates from HIV+ patients with oral candidiasis; alkaline upregulated 7187 MAM33 Predicted ORF in Assemblies 19, 20 and 21; regulated by Ssn6p; protein detected by mass spec in exponential and stationary phase cultures 3026 MAS1 Predicted ORF in Assemblies 19, 20 and 21; transcription is regulated by Nrg1p; oxidative stress-induced via Cap1p 6295 MAS2 Predicted ORF in Assemblies 19, 20 and 21; protein level decreased in stationary phase cultures 3294 MBF1 Predicted ORF in Assemblies 19, 20 and 21; caspofungin repressed 5855 MBP1 Predicted ORF in Assemblies 19, 20 and 21; non-periodic mRNA expression; predicted, conserved MBF binding sites upstream of G1/S-regulated genes 5995 MCA1 Putative cysteine protease with similarity to S. cerevisiae Mca1p; has a role in apoptotic cell death upon H2O2 treatment; fungal-specific (no human or murine homolog); farnesol-induced 7634 MCD1 Protein similar to S. cerevisiae Mcd1p; transcription is repressed in response to alpha pheromone in SpiderM medium; cell-cycle regulated periodic mRNA expression 5244 MCD4 Protein of major facilitator superfamily; has phosphodiesterase/nucleotide pyrophosphatase domain; similar to S. cerevisiae Mcd4p, which acts in GPI anchor biosynthesis 7025 MCM1 Transcription factor; regulator of hyphal growth; may act with Wor1p; canonical and non-canonical binding sites; MADS domain DNA-binding motif; similar to S. cerevisiae Mcm1p; greater expression in white than opaque cells; intron in 5'-UTR 4354 MCM2 Phosphorylated protein of unknown function; transcription is periodic with a peak at M/G1 phase of the cell cycle; predicted ORF in Assemblies 19, 20 and 21 1901 MCM3 Predicted ORF in Assemblies 19, 20 and 21; periodic mRNA expression, peak at cell-cycle M/G1 phase 2611 MCM6 Protein described as part of MCM DNA replication initiation complex; mRNA expression, peak at cell-cycle M/G1 phase; regulated by tyrosol and cell density; repressed in response to alpha pheromone in SpiderM medium 3507 MCR1 Protein described as NADH-cytochrome-b5 reductase; soluble protein in hyphae; biofilm induced; alkaline downregulated; ketoconazole or flucytosine induced, farnesol-induced 6643 MCT1 Putative malonyl-CoA acyl carrier protein acyltransferase 7481 MDH1 Protein described as malate dehydrogenase, mitochondrial; transcription regulated by Mig1p and Tup1p, white-opaque switching; induced in high iron, biofilm; regulated upon phagocytosis; antigenic during murine or human infection 4602 MDH1-1 Predicted malate dehydrogenase; macrophage-induced protein 5323 MDH1-3 Predicted malate dehydrogenase; farnesol regulated 2615 MDL1 Putative mitochondrial, half-size MDR-subfamily ABC transporter 5599 MDL2 Putative mitochondrial, half-size MDR-subfamily ABC transporter 1826 MDM34 Putative transcription factor with zinc finger DNA-binding motif; macrophage-downregulated gene 4697 MDN1 Protein induced during the mating process 5604 MDR1 Multidrug efflux pump of plasma membrane; member of the MDR family of major facilitator transporter superfamily; methotrexate is preferred substrate; overexpression in drug-resistant clinical isolates confers fluconazole resistance 6760 MDS3 Component of an alkaline pH-response pathway distinct from the Rim101p pathway, required for growth and hyphal formation at pH 9 and for full virulence in a mouse model of systemic infection; has a role in chlamydospore formation 5919 MEA1 Protein similar to A. nidulans MesA, which is involved in localization of actin cables 1283 MEC1 Protein described as cell cycle checkpoint protein; RNA abundance regulated by tyrosol and cell density 5485 MEC3 Increased transcription is observed upon benomyl treatment 4497 MED8 Protein not essential for viability; similar to S. cerevisiae Med8p, which is a subunit of the RNA polymerase II mediator complex 6208 MEF2 Predicted ORF in Assemblies 19, 20 and 21; caspofungin induced 1614 MEP1 Ammonium permease; Mep1p is a more efficient ammonium permease than Mep2p, whereas Mep2p has additional regulatory role; not essential for viability; 11 predicted transmembrane regions; low mRNA abundance; hyphal downregulated 5672 MEP2 Ammonium permease and regulator of nitrogen starvation-induced filamentation; 11 predicted transmembrane regions; in low nitrogen cytoplasmic C-terminus activates Ras/cAMP and MAPK signal transduction pathways to induce filamentation 3955 MES1 Cytoplasmic methionyl-tRNA synthetase (MetRS); has zinc-binding motif; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 5811 MET1 Putative uroporphyrin-3 C-methyltransferase; enzyme of methionine biosynthesis; upregulated in the presence of human whole blood or polymorphonuclear (PMN) cells; Hog1p-induced; fungal-specific (no human or murine homolog) 4076 MET10 Predicted enzyme of sulfur amino acid metabolism; biofilm-induced expression; upregulated in the presence of human whole blood or polymorphonuclear (PMN) cells; Hog1p-induced; possibly adherence-induced 2887 MET13 Predicted ORF in Assemblies 19, 20 and 21; ketoconazole-induced; amphotericin B repressed 946 MET14 Predicted ORF in Assemblies 19, 20 and 21; predicted role in sulfur metabolism; induced upon biofilm formation; possibly adherence-induced 5645 MET15 O-acetylhomoserine O-acetylserine sulfhydrylase; involved in sulfur amino acid biosynthesis; immunogenic; Hog1p, biofilm, possibly adherence-induced; brown colony color of homozygous mutant in Pb(2+) medium is visual selection marker 3106 MET16 Putative 3'-phosphoadenylsulfate reductase; predicted enzyme of sulfur amino acid metabolism; reports differ on regulation during biofilm formation; fungal-specific (no human or murine homolog) 1706 MET18 Predicted ORF in Assemblies 19, 20 and 21; Plc1p-regulated 2618 MET2 Putative homoserine acetyltransferase; Gcn4p-regulated; macrophage/pseudohyphal-repressed; not greatly biofilm induced, in contrast to many sulfur amino acid metabolic genes; no human or murine homolog; virulence-group-correlated expression 7046 MET28 Protein induced during the mating process 5025 MET3 Putative ATP sulfurlyase of sulfate assimilation; repressed by Met or Cys, Sfu1p, or in fluconazole-resistant isolate; strongly induced on biofilm formation, even in presence of Met and Cys; Hog1p-, caspofungin-, possibly adherence-induced 2551 MET6 Essential 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase (cobalamin-independent methionine synthase); antigenic during murine or human systemic infection; heat shock, estrogen, possibly biofilm, and GCN-induced 6780 MET8 Predicted ORF in Assemblies 19, 20 and 21; regulated by Gcn2p and Gcn4p 6938 MEU1 Predicted ORF in Assemblies 19, 20 and 21;protein level decreased in stationary phase cultures 488 MEX67 Nuclear export protein; has NTF2-like domain; interacts with Mtr2p via the NTF2-like domain 2164.1 MFA1 Mating pheromone, a-factor; produced in opaque MTLa cells; required for mating competence of MTLa cells, but not MTLalpha; induced by alpha-factor 4481 MFALPHA Alpha factor mating pheromone precursor; three copies of pheromone that are proteolytically processed by Kex2p and possibly by Orf19.5851p; required for alpha cells to mate; expressed specifically in opaque phase MTLalpha/MTLalpha cells 2524 MGE1 Predicted ORF in Assemblies 19, 20 and 21; macrophage/pseudohyphal-repressed 2956 MGM101 Putative mitochondrial genome maintenance protein; fungal-specific (no human or murine homolog); mutation confers hypersensitivity to tubercidin (7-deazaadenosine) 6621 MHP1 Protein similar to S. cerevisiae Mhp1p, which is involved in microtubule stabilization; transposon mutation affects filamentous growth; possibly transcriptionally regulated upon hyphal formation 3212 MID1 Putative stretch-activated Ca2+ channel of the high affinity calcium uptake system; role in thigmotropism; decreased transcription is observed upon fluphenazine treatment or in an azole-resistant strain with CDR1 and CDR2 overexpression 5551 MIF2 Centromere-associated protein; similar to CENP-C proteins; Cse4p and Mif2p colocalize at C. albicans centromeres 4318 MIG1 Transcriptional repressor; regulates genes for utilization of carbon sources; Tup1p-dependent and -independent functions; upregulated in biofilm; hyphal downregulated; caspofungin repressed; functional homolog of S. cerevisiae Mig1p 3071 MIH1 Putative protein phosphatase of the PTP family (tyrosine-specific), similar to S. cerevisiae Mih1p 4885 MIR1 Putative mitochondrial phosphate transporter; caspofungin repressed; expression is increased in a fluconazole-resistant isolate; induced upon adherence to polystyrene 2364 MIS11 Similar to precursor of mitochondrial C1-tetrahydrofolate synthase; putative protein of glycine catabolism; downregulated by Efg1p; fluconazole-induced; protein detected by mass spec in stationary phase cultures 7534 MIS12 Predicted ORF in Assemblies 19, 20 and 21 4077 MIT1 Protein involved in sphingolipid biosynthesis; required for mannosylation of inositol phosphoceramide (IPC) to form mannosylated sphingolipids MIPC and M(IP)2C; fluconazole, caspofungin induced; macrophage-downregulated gene 7523 MKC1 MAP kinase; role in biofilm formation, contact-induced invasive filamentation, systemic virulence in mouse, cell wall structure/maintenance, caspofungin response; phosphorylated on surface contact, membrane perturbation, or cell wall stress 6889 MKK2 Protein not essential for viability; similar to S. cerevisiae Mkk2p, which is a MAP kinase kinase involved in signal transduction; macrophage-downregulated gene 2416.1 MLC1 Protein with microtubule-dependent localization to the Spitzenkorper, also localizes to cytokinetic ring in hyphae; cell-cycle dependent localization to bud tip (polarisome) and bud neck in yeast and pseudohyphal cells 4162 MLH1 Predicted ORF in Assemblies 19, 20 and 21; cell-cycle regulated periodic mRNA expression 4683 MLP1 Protein similar to S. cerevisiae Mlp1p, which is a myosin-like protein 4833 MLS1 Malate synthase; enzyme of the glyoxylate cycle; peroxisomal; no mammalian homolog; transcription is induced upon phagocytosis by macrophage; regulated upon white-opaque switching; biofilm-repressed; strong oxidative stress induced 5100 MLT1 Vacuolar membrane transporter: MRP subfamily of ABC family; similar to S. cerevisiae Bpt1p and Ycf1p; may transport organic anions conjugated to glutathione, glucuronate, or sulfate; required for virulence in mouse peritonitis model 6220.3 MMD1 ORF Predicted by Annotation Working Group; macrophage-downregulated protein abundance 7413 MMS21 Predicted ORF in Assemblies 19, 20 and 21 6121 MNL1 Transcription factor that activates transcription of stress response genes via SLE (STRE-like) elements, required for adaptation to weak acid stress; activates a subset of the genes that are repressed by Nrg1p 4279 MNN1 Putative alpha-1,3-mannosyltransferase, a component of mannosyltransferase complex; transcription is negatively regulated by Rim101p; transcription is elevated in chk1 and nik1 homozygous null mutants, but not in the sln1 null mutant 5658 MNN10 Protein with similarity to mannosyltransferases; fungal-specific (no human or murine homolog) 2927 MNN11 Protein with similarity to mannosyltransferases 2347 MNN2 Alpha-1,2-mannosyltransferase; likely involved in iron utilization in the endocytosis pathway under iron-limiting conditions; similar to S. cerevisiae Mnn2p and Mnn5p; transposon mutation affects filamentous growth; filament induced 3803 MNN22 Protein described as similar to Golgi alpha-1,2-mannosyltransferase; regulated by Tsa1p, Tsa1Bp in minimal media at 37 deg; Hog1p-induced; induced by nitric oxide; downregulated in core stress response 4874 MNN3 Predicted Golgi alpha-1,2-mannosyltransferase; mutation confers hypersensitivity to toxic ergosterol analog, and to amphotericin B 2881 MNN4 Protein required for normal mannosylphosphorylation of oligosaccharides linked to cell wall proteins, not required for virulence or kidney colonization in mouse systemic infection or for normal interaction with macrophages 5557 MNN4-4 Putative mannosyltransferase; transcription is upregulated in a mutant lacking the Ssk1p response regulator proteinor in a nik1 homozygous null mutant, but not in chk1 or sln1 null mutants; pheromone induced 6692 MNN7 Protein described as mannosyltransferase; identified in detergent-resistant membrane fraction (possible lipid raft component); predicted N-terminal acetylation and transmembrane helix 7383 MNN9 Protein of N-linked outer-chain mannan biosynthesis; mutant has defective cell wall; required for wild-type hyphal growth; mutant is hygromycin B sensitive and vanadate resistant; has N-terminal membrane-spanning segment (positions 18-34) 5667 MNR2 Putative ion transporter; fungal-specific (no human or murine homolog) 1036 MNS1 Alpha-1,2-mannosidase; ER form is converted by Kex2p to a cytosolic form; processes Man9GlcNAc2 to Man8GlcNAc2 isomer B; member of endoplasmic-reticulum localized glycosyl hydrolase family 47 1665 MNT1 Alpha-1,2-mannosyl transferase; adds second mannose during cell-wall mannoprotein biosynthesis; required for wild-type virulence and adherence to epithelial cells; predicted type II membrane protein of Golgi; fungal-specific 1663 MNT2 Alpha-1,2-mannosyl transferase; adds third mannose during cell-wall mannoprotein biosynthesis; partially redundant with Mnt1p; role in adherence and virulence; expressed in yeast-form and hyphal cells; fungal-specific 1010 MNT3 Protein with similarity to mannosyltransferases; transcription is elevated in cyr1, chk1, nik1, and sln1 homozygous null mutants; fungal-specific (no human or murine homolog) 6313 MNT4 Transcriptionally regulated by iron; expression greater in low iron; similar to mannosyltransferases 5528 MOB1 Predicted ORF in Assemblies 19, 20 and 21; periodic mRNA expression, peak at cell-cycle G2/M phase 6044 MOB2 Mob1/phocein domain protein of RAM signaling network of cell wall integrity; role in cell separation, cortical actin polarization; required for hyphal growth; interacts with Cbk1p; functional homolog of S. cerevisiae Mob2p 5029 MODF Predicted ORF in Assemblies 19, 20 and 21; ABC family protein; similar to E. coli ModF/PhrA protein, which may have a role in molybdate metabolism; no human or murine homolog 3369 MOH1 Protein similar to S. cerevisiae Moh1p; transcription is induced in response to alpha pheromone in SpiderM medium; transcriptionally activated by Mnl1p under weak acid stress 1779 MP65 Cell surface mannoprotein; mycelial antigen; possible role in cell-wall glucan metabolism; has adhesin motif; O-glycosylation but no predicted N-glycosylation; induced by heat, upon germ tube formation, wall regeneration; diagnostic marker 2919 MPH1 Protein similar to S. cerevisiae Mph1p, which is a DNA helicase involved in DNA repair; induced under hydroxyurea treatment 1915 MPP10 Predicted ORF in Assemblies 19, 20 and 21; downregulated in core stress response; decreased expression in response to prostaglandins 7293 MPS1 Predicted ORF in Assemblies 19, 20 and 21; essential for growth; periodic mRNA expression, peak at cell-cycle S/G2 phase 4991 MPT5 Protein induced during the mating process 6915 MRE11 Protein described as DNA double-strand break repair factor; involved in response to oxidative stress and drug resistance 1149 MRF1 Protein similar to mitochondrial respiratory proteins; increased transcription observed upon benomyl treatment; induced by farnesol, nitric oxide, core stress response; oxidative stress-induced via Cap1p 947 MRP17 Predicted mitochondrial ribosomal protein 4023 MRP2 Protein similar to S. cerevisiae Mrp2p, which is a component of the small subunit of the mitochondrial ribosome; transposon mutation affects filamentous growth 3350 MRP20 Protein described as component of mitochondrial ribosome; decreased expression in hyphae compared to yeast-form cells 3844 MRP8 Protein not essential for viability; similar to S. cerevisiae Mrp8p, which is a mitochondrial ribosomal protein; greater transcription in hyphal form than yeast form 3532 MRPL10 Predicted ORF in Assemblies 19, 20 and 21; shows colony morphology-related gene regulation by Ssn6p 6231 MRPL19 Protein described as a ribosomal protein; induced upon adherence to polystyrene 3064 MRPL27 Putative ribosomal protein 5064 MRPL3 Predicted ORF in Assemblies 19, 20 and 21; downregulated in core stress response; protein detected by mass spec in exponential and stationary phase cultures 2511.1 MRPL33 ORF predicted by Annotation Working Group; increased expression observed in an ssr1 homozygous null mutant; transcription is upregulated in both intermediate and mature biofilms 755 MRPL37 Predicted ORF in Assemblies 19, 20 and 21; shows colony morphology-related gene regulation by Ssn6p 484 MRPL40 Putative mitochondrial ribosomal protein 7486 MRPL6 Putative mitochondrial ribosomal protein 6129 MRPL8 Predicted ribosomal protein of the mitochondrial 60S subunit 5230 MRPS9 Mitochondrial ribosomal protein S9; has N-terminal mitochondrial targeting signal and an S9 consensus motif; overexpression in S. cerevisiae causes respiratory defect that is reversible upon cessation of C. albicans gene expression 7372 MRR1 Regulator of MDR1 transcription; zinc-finger protein; gain-of-function mutations cause upregulation of MDR1 (which encodes plasma membrane multidrug efflux pump) and consequent multidrug resistance 2597 MRS2 Putative magnesium ion transporter, mitochondrial; fungal-specific (no human or murine homolog) 5550 MRT4 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to tubercidin (7-deazaadenosine); transcription is upregulated in both intermediate and mature biofilms 1133 MSB1 Predicted ORF in Assemblies 19, 20 and 21; expression in S. cerevisiae flo8 and flo11 mutants suggests a role in regulation of adhesion factors 1490 MSB2 Mucin family member, possible sensor of cell wall damage; required for Cek1p phosphorylation in response to cell wall stress; transcription is negatively regulated by Rim101p 2039 MSF1 Predicted ORF in Assemblies 19, 20 and 21; protein level decreased in stationary phase cultures 3093 MSH2 Protein described as DNA mismatch repair factor; transcription is regulated by Nrg1p; flucytosine repressed; RNA abundance regulated by tyrosol and cell density 4945 MSH6 Protein similar to S. cerevisiae Msh6p, which is involved in mismatch repair; repressed under Cdc5p depletion 2435 MSI3 Protein of the HSP70 family; antigenic; functional homolog of S. cerevisiae Msi3p; physically interacts (by 2-hybrid) with Cgr1p; transcriptionally regulated by iron; expression greater in high iron; farnesol downregulated in biofilm 6533 MSK1 Predicted ORF in Assemblies 19, 20 and 21; flucytosine repressed 3950 MSM1 Mitochondrial methionyl-tRNA synthetase (MetRS); functionally complements methionine auxotrophy of an E. coli MetRS mutant; transcription is regulated by Nrg1p 4752 MSN4 Putative zinc finger transcription factor; similar to S. cerevisiae Msn4p, but not a significant stress response regulator in C. albicans; partly complements STRE-activation defect of S. cerevisiae msn2 msn4 double mutant 2665 MSN5 Predicted ORF in Assemblies 19, 20 and 21 5248 MSO1 Predicted ORF in Assemblies 19, 20 and 21; expression is down-regulated during pseudohyphal growth in the presence of lysed macrophages 6309 MSS11 Transcriptional activator, binds to Flo8p via a LisH motif to cooperatively activate transcription of hyphal-specific genes; required for hyphal growth 4739 MSS116 Predicted ORF in Assemblies 19, 20 and 21; transcription is upregulated in both intermediate and mature biofilms 3153 MSS4 Phosphatidylinositol-4-phosphate 5-kinase; activity induced by phosphatidic acid (Pld1p product); associated with hyphal growth under some, not all, conditions; functional homolog of S. cerevisiae Mss4p; macrophage/pseudohyphal-repressed 7577 MSS51 Putative mRNA maturation factor; fungal-specific (no human or murine homolog) 4299 MSW1 Protein likely to be essential for growth, based on an insertional mutagenesis strategy; similar to S. cerevisiae Msw1p, which is mitochondrial tryptophanyl-tRNA synthetase 3201 MTLA1 A1p and Alpha2p act together to repress white-opaque switching and mating (an opaque-specific process); homeodomain protein; gene of the MTLa (Mating Type Like) locus; a/alpha mating type may increase virulence, competitive advantage 3200 MTLA2 Master regulator (activator) of a-type mating; has HMG domain, which is predicted to bind DNA; gene has intron; not related to S. cerevisiae MATa2; a/alpha mating type may increase virulence, provides competitive advantage 10712 MTLALPHA1 Master regulator (activator) of alpha mating type; gene of the MTLalpha (Mating Type Like) locus; ortholog of S. cerevisiae Alpha1p; a/alpha mating type may increase virulence, offers competitive advantage 5050 MTO1 Predicted ORF in Assemblies 19, 20 and 21; transcription is upregulated in both intermediate and mature biofilms 1119 MTR10 Putative importin, member of a family of fungal-specific nuclear importins; transcription is regulated by Mig1p 5342.1 MTR2 Nuclear export protein; member of NTF2 family; monomeric in solution; interacts with Mex67p via the NTF2-like domain 1367 MTW1 Kinetochore component; amount of Nuf2p and Mtw1p protein detected at each centromere is consistent with a single kinetochore microtubule attachment site 7412 MUB1 Protein not essential for viability; similar to S. cerevisiae Mub1p, which has a role in regulation of budding 4183 MUC1 Protein not essential for viability; similar to S. cerevisiae Muc1p, which is a cell surface glycoprotein involved in filamentous growth; decreased transcription is observed upon benomyl treatment 4044 MUM2 Protein similar to S. cerevisiae Mum2p; transcription is induced in response to alpha pheromone in SpiderM medium; transcription is regulated by Tup1p 5280 MUP1 Alkaline upregulated by Rim101p 2107 MUQ1 Protein described as choline phosphate cytidylyltransferase/phosphoethanolamine cytidylyltransferase; decreased expression in hyphae compared to yeast-form cells 6105 MVD Mevalonate diphosphate decarboxylase; functional homolog of S. cerevisiae Erg19p; possible drug target; transcriptionally regulated by carbon source, yeast-hyphal switch, growth phase, antifungals; gene has intron 2028 MXR1 Protein described as a methionine sulfoxide reductase; flucytosine induced; Plc1p-regulated; upregulated in the presence of human neutrophils; macrophage regulated (gene induced, protein decreased); possibly adherence-induced 6294 MYO1 Component of actomyosin ring at neck of newly-emerged bud 5015 MYO2 Class V myosin; nonessential; required for wild-type actin cytoskeletal polarity, nuclear organization and migration, and hyphal growth; sole class V myosin in C. albicans; conserved myosin ATPase and tail domains 738 MYO5 Class I myosin; nonessential; role in cortical actin patch polarity and polar budding; required for hyphal growth; regulatory phosphorylation on S366; downregulated on adherence to polystyrene; sole class I myosin in C. albicans 5530 NAB3 Predicted ORF in Assemblies 19, 20 and 21; flucytosine repressed 2156 NAG1 Glucosamine-6-phosphate deaminase; enzyme of N-acetylglucosamine utilization; required for wild-type hyphal growth and mouse virulence; converts glucosamine 6-P to fructose 6-P; reaction is reversible in vitro; gene is GlcNAc-induced 2158 NAG3 Putative transporter of the major facilitator superfamily (MFS); similar to Nag4p; required for wild-type mouse virulence and cycloheximide resistance; in gene cluster that includes genes encoding enzymes of GlcNAc catabolism 2160 NAG4 Putative transporter; fungal-specific; similar to Nag3p and to S. cerevisiae Ypr156Cp and Ygr138Cp; required for wild-type mouse virulence and wild-type cycloheximide resistance; gene cluster encodes enzymes of GlcNAc catabolism 2151 NAG6 Protein required for wild-type mouse virulence and wild-type cycloheximide resistance; putative GTP-binding motif; similar to S. cerevisiae Yor165Wp; in gene cluster that encodes enzymes of GlcNAc catabolism; no human or murine homolog 5705 NAM2 Putative mitochondrial leucyl-tRNA synthetase 939 NAM7 Putative role in nonsense-mediated mRNA decay; similar to S. cerevisiae Nam7p; gene induced by ciclopirox olamine treatment 2688 NAN1 Predicted ORF in Assemblies 19, 20 and 21; physically interacts with TAP-tagged Nop1p 4757 NAR1 Predicted ORF in Assemblies 19, 20 and 21; induced by nitric oxide; oxidative stress-induced via Cap1p 2116 NAT2 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to toxic ergosterol analog 878 NBN1 Subunit of the NuA4 histone acetyltransferase complex; Plc1p-regulated 747 NBP35 Similar to nucleotide-binding proteins; increased transcription is observed upon benomyl treatment; transcription is induced upon filamentous growth 1721 NCE103 Carbonic anhydrase involved in the conversion of carbon dioxide to bicarbonate; essential for pathogenesis in host niches with limited CO2, wild-type white-opaque switching; biofilm induced; activated by Mnl1p under weak acid stress 5320 NCE4 Predicted ORF in Assemblies 19, 20 and 21; periodic mRNA expression, peak at cell-cycle G2/M phase 2672 NCP1 NADPH-cytochrome P450 reductase, acts with Erg11p in sterol 14 alpha-demethylation in ergosterol biosynthesis; subject to hypoxic regulation; ketoconazole-induced; caspofungin repressed 7242 NCR1 Transcription is regulated by Nrg1p and Mig1p; increased expression in response to prostaglandins 339 NDE1 Putative NADH dehydrogenase that could act alternatively to complex I in respiration; caspofungin repressed; fungal-specific (no human or murine homolog); transcription is upregulated in both intermediate and mature biofilms 4495 NDH51 Subunit of nicotinamide adenine dinucleotide dehydrogenase complex I, of the mitochondrial electron transport chain; required for wild-type filamentous growth; alkaline downregulated 2119 NDT80 Activator of CDR1 induction by antifungal drugs; required for wild-type drug resistance; transcriptionally induced upon antifungal drug treatment; similar to S. cerevisiae Ndt80p, which is a meiosis-specific transcriptional regulator 665 NEP1 Protein of unknown function; ortholog of S. cerevisiae Emg1p, which is involved in ribosome biogenesis 5392 NGT1 N-acetylglucosamine (GlcNAc)-specific transporter; role in GlcNAc (but not serum) induced hyphal growth; localizes to plasma membrane; induced by GlcNAc, macrophage engulfment; 12 transmembrane, major facilitator superfamily 526 NHP2 Predicted ORF in Assemblies 19, 20 and 21; macrophage/pseudohyphal-induced 4623.3 NHP6A Protein described as nonhistone chromatin component; RNA abundance regulated by tyrosol and cell density; amphotericin B, caspofungin repressed; intron in 5'-UTR 4201 NHX1 Protein similar to S. cerevisiae Nhx1p, which is an Na+/H+ exchanger required for intracellular sequestration of Na+ 5181 NIK1 Histidine kinase involved in a two-component signaling pathway that regulates cell wall biosynthesis; required for wild-type virulence in mouse systemic infection but not for wild-type growth or drug sensitivity/resistance 4635 NIP1 Putative translation initiation factor; mutation confers hypersensitivity to roridin A and verrucarin A; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 486 NIP100 Predicted ORF in Assemblies 19, 20 and 21 3478 NIP7 Protein described as a nucleolar protein with role in ribosomal assembly; hyphal induced 2351 NIT3 Predicted ORF in Assemblies 19, 20 and 21; regulated by Gcn2p and Gcn4p; protein detected by mass spec in exponential and stationary phase cultures 3288 NMA111 Predicted ORF in Assemblies 19, 20 and 21; macrophage-induced gene; downregulated in core stress response; fungal-specific (no human or murine homolog); merged with orf19.3288.1 in Assembly 21 706 NMD3 Predicted ORF in Assemblies 19, 20 and 21; downregulated in core stress response; decreased expression in response to prostaglandins 4188 NMD5 Protein not essential for viability; similar to S. cerevisiae Nmd5p, which is involved in protein-nucleus import; downregulated during core stress response 4641 NMT1 Myristoyl-CoA:protein N-myristoyltransferase; attaches the fatty acid myristate to a small number of proteins at an N-terminal Gly; essential; antifungal drug target; functional homolog of S. cerevisiae Nmt1p 5850 NOC2 Protein similar to S. cerevisiae Noc2p; transposon mutation affects filamentous growth; mutation confers hypersensitivity to 5-fluorouracil (5-FU), tubercidin (7-deazaadenosine); downregulated during core stress response 1902 NOC4 Predicted ORF in Assemblies 19, 20 and 21; mutation confers resistance to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine) 7384 NOG1 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine); decreased expression in response to prostaglandins 5732 NOG2 Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins 3138 NOP1 Nucleolar protein; flucytosine induced 596.1 NOP10 ORF Predicted by Annotation Working Group; flucytosine induced 5959 NOP14 Predicted ORF in Assemblies 19, 20 and 21; mutation confers resistance to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine); heterozygous null mutant exhibits resistance to parnafungin 7050 NOP15 Protein described as a nucleolar ribosome biogenesis factor; hyphal-induced expression 5198 NOP4 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine); downregulated in core stress response 1199 NOP5 Protein similar to S. cerevisiae Nop5p protein of small nucleolar ribonucleoprotein complex; transposon mutation affects filamentous growth; macrophage/pseudohyphal-induced; physically interacts with TAP-tagged Nop1p 4093 NOP7 Pescadillo homolog required for filament-to-yeast switching; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine) 2012 NOT3 Protein with similarity to Not5p, putative transcriptional regulator; not required for adherence to buccal epithelial cells or for virulence in mouse systemic infection; null mutant colonies exhibit slightly decreased filamentation ratio 2379 NOT4 Putative E3 ubiquitin-protein ligase; required for maintenance, but not induction, of hyphal development; homozygous null mutant is avirulent in mouse systemic infection despite persistence in host; repressed in rat oral candidiasis 5107 NOT5 Protein with similarity to S. cerevisiae Not5p, which is a member of the transcription regulatory CCR4-NOT complex; required for hyphal growth; antigenic during human oral infection; greater expression in yeast-form cells than hyphae 7238 NPL3 Putative RNA-binding protein, ortholog of S. cerevisiae Npl3p; nuclear export is facilitated by Hmt1p; transcription is upregulated in an RHE model of oral candidiasis 2434 NPL4 Predicted ORF in Assemblies 19, 20 and 21; regulated by Gcn2p and Gcn4p 2055 NPL6 Putative nuclear protein localization factor; fungal-specific (no human or murine homolog) 6232 NPR1 Predicted ORF in Assemblies 19, 20 and 21; induced in core stress response 328 NPR2 Predicted ORF in Assemblies 19, 20 and 21; induced during infection of murine kidney, compared to growth in vitro; has murine homolog 7176 NPT1 Putative nicotinate phosphoribosyltransferase, involved in NAD salvage pathway; fungal-specific (no human or murine homolog) 7150 NRG1 Transcriptional repressor; regulates hyphal genes, virulence genes, chlamydospore development, and genes involved in rescue and stress responses; effects both Tup1p-dependent (major) and -independent (minor) regulation 6339 NRG2 Protein similar to S. cerevisiae Nrg2p transcription factor, which regulates invasive growth in S. cerevisiae; transposon mutation affects filamentous growth 5071 NRP1 Predicted ORF in Assemblies 19, 20 and 21; fungal-specific (no human or murine homolog) 2185 NSA1 Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins 7424 NSA2 Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins 4879.2 NTF2 ORF Predicted by Annotation Working Group; regulated by Ssn6p 5098 NTG1 Protein with strong similarity to both S. cerevisiae Ntg1p and Ntg2p DNA repair glycosylases; transcriptionally regulated by iron; expression greater in high iron 7479 NTH1 Neutral trehalase; hyphal induction in homozygous null mutant is delayed but not reduced overall; not required for virulence in mouse systemic infection; homodimeric enzyme; possible regulatory cAMP-dependent phosphorylation at S10 and S213 6531 NUC2 Protein described as NADH-ubiquinone oxidoreductase; identified in detergent-resistant membrane fraction (possible lipid raft component); alkaline downregulated 1941 NUF2 Kinetochore component; amount of Nuf2p and Mtw1p protein detected at each centromere is consistent with a single kinetochore microtubule attachment site 6570 NUP Nucleoside permease; adenosine and guanosine are substrates, whereas cytidine, adenine, guanine, uridine, uracil are not; similar to a nucleoside permease of S. pombe; possibly processed by Kex2p 4808 NUP188 Transcription is regulated by Nrg1p and Mig1p 4987 NUP49 Nuclear pore protein 2901 NUP60 Protein not essential for viability; similar to S. cerevisiae Nup60p, which is a subunit of the nuclear pore complex 5887 NUP85 Protein not essential for viability; similar to S. cerevisiae Nup85p, which is a subunit of the nuclear pore complex 7411 OAC1 Predicted ORF in Assemblies 19, 20 and 21; transcription is upregulated in both intermediate and mature biofilms 3198 OBPA Similar to oxysterol binding protein; gene is located within the MTLa mating-type-like locus; Plc1p-regulated 1762 OCA1 Putative protein phosphatase of the PTP family (tyrosine-specific), similar to S. cerevisiae Oca1p; mutant shows virulence defect; not essential for viability 7206 OCA6 Putative protein phosphatase of the PTP family (tyrosine-specific), similar to S. cerevisiae Oca6p; mutant shows virulence defect 7391 OCH1 alpha-1,6-mannosyltransferase; initiates N-glycan outer chain branch addition; similar to S. cerevisiae Och1p; required for wild-type virulence in mouse intravenous infection; fungal-specific (no human or murine homolog) 7190 OGG1 Ortholog of S. cerevisiae OGG1, which encodes a mitochondrial DNA glycosylase/lyase involved in base excision repair; predicted ORF in Assemblies 19, 20 and 21 5117 OLE1 Fatty acid desaturase (stearoyl-CoA desaturase), essential protein involved in oleic acid synthesis; required for aerobic hyphal growth and chlamydospore formation; subject to hypoxic regulation; fluconazole-induced; caspofungin repressed 2264 OLE2 Protein with similarity to fatty acid desaturase (stearoyl-CoA desaturase); homozygous null mutant shows decreased production of prostaglandin E2 4934 OP4 Ala- Leu- and Ser-rich protein; N-terminal hydrophobic region; possible glycosylation; gene is transcribed specifically in opaque-phase cells, repressed by alpha pheromone in opaque MTLa homozygotes 1543 OPI1 Functional homolog of S. cerevisiae Opi1p, which is a transcriptional repressor of INO1 involved in inositol biosynthesis; has leucine zipper and putative Opi1-Sin3 interaction domain; interacts with ScSin3p, but not CaSin3p 7446 OPI3 Putative phosphatidylethanolamine N-methyltransferase of phosphatidylcholine biosynthesis; downregulation correlates with clinical development of fluconazole resistance; amphotericin B repressed; caspofungin repressed 2602 OPT1 Oligopeptide transporter; transports 3-to-5-residue peptides; alleles are distinct, one has intron; not ABC or PTR type transporter; suppresses S. cerevisiae ptr2-2 mutant defects; induced by BSA or peptides; Stp3p, Hog1p regulated 176 OPT4 Oligopeptide transporter; detected at germ tube plasma membrane by mass spectrometry; transcriptionally induced upon phagocytosis by macrophage; fungal-specific (no human or murine homolog); merged with orf19.2292 in Assembly 20 5121 OPT5 Oligopeptide transporter; fungal-specific (no human or murine homolog); induced by BSA, but not by tetrapeptide or pentapeptide 4655 OPT6 Putative oligopeptide transporter; fungal-specific (no human or murine homolog); expression of OPT6, OPT7, or OPT8 does not suppress defect of mutant lacking Opt1p, Opt2p, and Opt3p; alleles are nonidentical 5673 OPT7 Putative oligopeptide transporter; possibly transports GSH and related compounds; induced upon biofilm formation; Hog1p-induced; expression of OPT6, -7, or -8 does not suppress defect of mutant lacking Opt1p, -2p, or -3p; fungal-specific 5770 OPT8 Possible oligopeptide transporter; similar to Opt1p and to S. cerevisiae Ygl114wp, but not other OPTs; induced by nitric oxide, amphotericin B; expression of OPT6, -7, or -8 does not suppress defect of mutant lacking Opt1p, Opt2p, and Opt3p 2584 OPT9 Probable pseudogene similar to fragments of OPT1 oligopeptide transporter gene; decreased expression in hyphae compared to yeast-form cells; transcriptionally induced upon phagocytosis by macrophage 5110 OPY2 Predicted ORF in Assemblies 19, 20 and 21 3000 ORC1 Predicted ORF in Assemblies 19, 20 and 21; essential for viability; similar to S. cerevisiae Orc1p origin recognition complex subunit 6942 ORC3 Protein similar to S. cerevisiae Orc3p, which is a component of the origin recognition complex involved in DNA replication; mutation confers hypersensitivity to toxic ergosterol analog; induced under hydroxyurea treatment 4221 ORC4 Phosphorylated protein similar to S. cerevisiae Orc4p; transcription is induced in response to alpha pheromone in SpiderM medium 2219 ORF298 Predicted ORF in retrotransposon Tca3 with similarity to the Gag-Pol region of retrotransposons, which encodes nucleocapsid-like protein, reverse transcriptase, protease, and integrase; transcription is a-specific, alpha-factor induced 5751 ORM1 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to aureobasidin A 1317 OSH3 Protein required for wild-type filamentation; has oxysterol binding protein domain and pleckstrin homology motif; overproducton suppresses cph1 homozygous null filamnetation defect; similar to S. cerevisiae Osh3p 6882 OSM1 Putative flavoprotein subunit of fumarate reductase; soluble protein in hyphae; fungal-specific (no human or murine homolog); caspofungin repressed; protein detected by mass spec in stationary phase cultures 5005 OSM2 Protein described as mitochondrial fumarate reductase; regulated by Ssn6p, Gcn2p, and Gcn4p; Hog1p-downregulated; protein detected by mass spec in stationary phase cultures 243 OXR1 Predicted ORF in Assemblies 19, 20 and 21 3443 OYE2 Putative NAPDH dehydrogenase; fungal-specific (no human or murine homolog); induced by nitric oxide 3234 OYE22 Predicted ORF in Assemblies 19, 20 and 21; transcription is upregulated in both intermediate and mature biofilms 3433 OYE23 Putative NAPDH dehydrogenase; induced by nitric oxide, benomyl; oxidative stress-induced via Cap1p; fungal-specific (no human or murine homolog) 3131 OYE32 Protein of NAD(P)H oxidoreductase family; induced by nitric oxide, amphotericin B, oxidative stress (via Cap1p); increased transcription associated with MDR1 overexpression or benomyl treatment; macrophage-downregulated protein abundance 5731 PAD1 Protein described as phenylacrylic acid decarboxylase; repressed by Rgt1p 7222 PAM16 Protein described as similar to maltase; regulated by Gcn4p; repressed in response to amino acid starvation (3-aminotriazole treatment); transcription is upregulated in both intermediate and mature biofilms 886 PAN1 Essential protein involved in endocytosis and polarized growth; similar to S. cerevisiae Pan1p, which is a part of a complex that regulates actin cytoskeleton 4010 PAN3 Protein not essential for viability; similar to S. cerevisiae Pan3p, which is a subunit of an RNAse complex that controls poly(A) tail length 3197 PAP1 Poly(A) polymerase, likely involved in mRNA polyadenylation; PAP is inhibited by parnafungin antifungals; gene is located within the MTLa mating-type-like locus 10713 PAPALPHA Putative poly(A) polymerase; PAP is inhibited by parnafungin antifungals; gene is located within the MTLalpha mating-type-like locus 5771 PBP2 Transcription is regulated by Nrg1p, Mig1p, and Tup1p 7388 PBS2 MAPK kinase (MAPKK); role in osmotic and oxidative stress responses, oxidative stress adaptation; required for stress regulation of Hog1p localization and activity; functional homolog of S. cerevisiae Pbs2p 7514 PCK1 Phosphoenolpyruvate carboxykinase; role in gluconeogenesis; regulated by hyphal switch, carbon source; repressed on glucose; induced by fluconazole, phagocytosis, H2O2; predicted ATP-dependent, dimeric; predicted PKC phosphorylation sites 2649 PCL1 Cyclin homolog; expression induced upon filamentous growth; transcription is induced in response to alpha pheromone in SpiderM medium 403 PCL2 Cyclin homolog; reduced expression observed upon depletion of Cln3p; farnesol regulated; periodic mRNA expression, peak at cell-cycle G1/S phase 4012 PCL5 Protein similar to S. cerevisiae Pcl5p and other cyclins for Pho85p kinase; Gcn4p-induced; suppresses toxicity of C. albicans Gcn4p overproduction in S. cerevisiae via increased Pho85p-dependent phosphorylation and degradation of Gcn4p 6225 PCL7 Protein described as cyclin-like, possible Pho85p cyclin; hyphal downregulated; transcriptionally activated by Mnl1p under weak acid stress 4186 PCT1 Putative choline-phosphate cytidylyl transferase, antigenic during human oral infection 3097 PDA1 Protein described as similar to alpha chain of pyruvate dehydrogenase; fluconazole-induced; protein detected by mass spec in exponential and stationary phase cultures 5294 PDB1 Protein described as similar to pyruvate dehydrogenase; fluconazole-induced; protein level decreased in stationary phase cultures 2877 PDC11 Protein similar to pyruvate decarboxylase; antigenic; at hyphal cell surface, not yeast-form cells; soluble in hyphae; regulated by Gcn4p, Efg1p, Efh1p; fluconazole-, farnesol-, biofilm-induced; repressed upon amino acid starvation 4608 PDC12 Putative pyruvate decarboxylase; fungal-specific (no human or murine homolog) 4863 PDC2 Transcriptional regulator of pyruvate decarboxylase; contains a putative C-terminal activation domain, Glu- and Pro-rich; complements glucose utilization defect of S. cerevisiae pdc2 mutant 4235 PDE1 Cyclic nucleotide phosphodiesterase (PDEase), low affinity; has activity toward cGMP and cAMP; not divalent cation-dependent; complements defects of an S. cerevisiae mutant lacking PDEase; macrophage-downregulated gene 2972 PDE2 Cyclic nucleotide phosphodiesterase, high affinity; role in moderating signaling via cAMP; required for wild-type virulence, hyphal growth, switching, and cell wall, but not for pseudohyphal growth; expressed shortly after hyphal induction 5130 PDI1 Protein described as protein disulfide-isomerase; antigenic in human; soluble protein in hyphae; transcription is induced upon filamentous growth 7281 PDK2 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to amphotericin B 2802 PDR10 Upregulated by Rim101p at pH 8; merged with orf19.918 in Assembly 20 1027 PDR16 Phosphatidylinositol transfer protein; increased transcription correlates with CDR1 and CDR2 overexpression and azole resistance; induced by fluphenazine, 17-beta-estradiol, ethynyl estradiol, nitric oxide; farnesol-downregulated in biofilm 5839 PDR17 Predicted ORF in Assemblies 19, 20 and 21; role in sensitivity to fluconazole, specifically; fungal-specific (no human or murine homolog) 2094 PDR6 Transcription is regulated by Nrg1p; transcription is induced in response to alpha pheromone in SpiderM medium 2216 PDS5 Predicted ORF in Assemblies 19, 20 and 21; cell-cycle regulated periodic mRNA expression 5021 PDX1 Pyruvate dehydrogenase complex protein X, an essential component of the mitochondrial pyruvate dehydrogenase complex which is involved in the respiratory pathway; protein detected by mass spec in exponential and stationary phase cultures 550 PDX3 Transcription is regulated upon yeast-hyphal switch; regulated by Nrg1p, Mig1p, and Tup1p; caspofungin repressed; protein detected by mass spec in exponential and stationary phase cultures 7072 PEL1 Predicted enzyme of mitochondrial phospholipid biosynthesis; upregulated in biofilm 5584 PEP3 Peptidase; activity useful for strain identification by multilocus enzyme electrophoresis (MLEE); clade-associated gene expression 5662 PEP7 Vesicle transport protein; acts in endosomal transport; roles in metal ion resistance, virulence, adhesion, hyphal growth, chlamydospore formation; similar to S. cerevisiae Pep7p 6927 PEP8 Protein similar to S. cerevisiae Pep8p, which is involved in retrograde transport; transposon mutation affects filamentous growth 930 PET9 Protein involved in ATP biosynthesis; identified in detergent-resistant membrane fraction (possible lipid raft component); 3 predicted transmembrane helices; flucytosine induced; ketoconazole-induced; downregulated by Efg1p 1089 PEX11 Putative protein involved in fatty acid oxidation; expression is Tac1p-dependent 7282 PEX13 Protein required for peroxisomal protein import mediated by PTS1 and PTS2 targeting sequences; transcription is upregulated in an RHE model of oral candidiasis 1805 PEX14 Protein not essential for viability; similar to S. cerevisiae Pex14p, which is a peroxisomal protein involved in import of peroxisomal matrix proteins 4426 PEX3 Putative peroxisomal protein involved in targeting proteins into peroxisomes 4041 PEX4 Predicted ORF in Assemblies 19, 20 and 21; transcription is upregulated in both intermediate and mature biofilms 5640 PEX5 Protein of the Pex5p family; required for PTS1-mediated peroxisomal protein import, fatty acid beta-oxidation; similar to S. cerevisiae Pas10p peroxisomal targeting receptor; macrophage/pseudohyphal-repressed 3967 PFK1 Alpha subunit of phosphofructokinase (PFK), which is Pfk1p, Pfk2p heteromultimer; PFK is activated by fructose 2,6-bisphosphate or AMP, inhibited by ATP; activity reduced on hyphal induction; phagocytosis-downregulated; fluconazole-induced 6540 PFK2 Beta subunit of phosphofructokinase (PFK), which is a heteromultimer of Pfk1p and Pfk2p; PFK is activated by fructose 2,6-bisphosphate or AMP, inhibited by ATP; downregulated upon phagocytosis or hyphal growth; fluconazole-induced 4753 PFK26 Protein repressed during the mating process 5076 PFY1 Profilin, functional homolog of S. cerevisiae Pfy1p; hyphal-induced; macrophage/pseudohyphal-induced; regulated by Nrg1p, Tup1p; gene lacks intron (unlike S. cerevisiae PFY1); complements growth of S. cerevisiae srv2 mutant; nonessential 7625 PGA1 Putative GPI-anchored protein of unknown function; induced during cell wall regeneration 5674 PGA10 Plasma membrane protein involved in heme-iron utilization; allows utilization of hemin and hemoglobin as iron sources in host tissues; predicted GPI anchor; hypoxia, ketoconazole, ciclopirox, or hyphal-induced; upregulated by Rim101p at pH8 7609 PGA11 Putative GPI-anchored protein of unknown function; possibly spurious ORF (Annotation Working Group prediction) 7597 PGA12 Putative GPI-anchored protein of unknown function 6420 PGA13 Putative GPI-anchored protein; described as similar to mucins; induced during cell wall regeneration, and during core caspofungin response; regulated by Tsa1p, Tsa1Bp in minimal media at 37 deg and by Cyr1p, Nrg1p, Tup1p, Rlm1p 968 PGA14 Putative GPI-anchored protein of unknown function; induced during cell wall regeneration; regulated by Ssn6p 2878 PGA15 Putative GPI-anchored protein of unknown function 848 PGA16 Putative GPI-anchored protein of unknown function; possibly spurious ORF (Annotation Working Group prediction) 893 PGA17 Putative GPI-anchored protein of unknown function; exogenously expressed protein is a substrate for Kex2p processing in vitro; transcription is repressed in response to alpha pheromone in SpiderM medium; macrophage-induced gene 301 PGA18 Putative GPI-anchored protein of unknown function; regulated by Nrg1p, Tup1p 2033 PGA19 Putative GPI-anchored protein; not essential for viability; macrophage-induced gene 3738 PGA22 Putative GPI-anchored protein of unknown function 3740 PGA23 Putative GPI-anchored protein of unknown function; transcription is negatively regulated by Rim101p; regulated by Cyr1p; shows colony morphology-related gene regulation by Ssn6p 6336 PGA25 Putative GPI-anchored protein of unknown function; fluconazole-downregulated 2475 PGA26 Putative GPI-anchored protein of unknown function; transcriptionally regulated by iron; expression greater in high iron; induced during cell wall regeneration; possibly spurious ORF (Annotation Working Group prediction) 2044 PGA27 Putative GPI-anchored protein of unknown function 5144 PGA28 Protein similar to S. cerevisiae Wsc2p, which has roles in stress- and cell-wall-related processes; predicted Kex2p substrate; putative GPI-anchored protein 5303 PGA30 Putative GPI-anchored protein of cell wall 5302 PGA31 Cell wall protein; putative GPI anchor; expression is regulated upon white-opaque switching; induced during cell wall regeneration; possibly spurious ORF (Annotation Working Group prediction) 6784 PGA32 Putative GPI-anchored protein of unknown function; transcriptionally regulated by iron; expression greater in high iron 876 PGA33 Putative GPI-anchored protein of unknown function; possibly spurious ORF (Annotation Working Group prediction) 2833 PGA34 Putative GPI-anchored protein of unknown function; transcription is repressed in response to alpha pheromone in SpiderM medium 3923 PGA37 Putative GPI-anchored protein of unknown function 2758 PGA38 Putative GPI-anchored protein of unknown function; repressed during cell wall regeneration 6302 PGA39 Putative GPI-anchored protein of unknown function 4035 PGA4 Cell-surface protein; predicted glycosylphosphatidylinositol (GPI) lipid anchor; similar to S. cerevisiae Gas1p; fungal-specific (no human or murine homolog); transcription is upregulated in RHE model of oral candidiasis 2906 PGA41 Putative GPI-anchored protein of unknown function 2907 PGA42 Putative GPI-anchored protein of unknown function; decreased transcription is observed in azole-resistant strains that overexpress CDR1 and CDR2 or MDR1; possibly spurious ORF (Annotation Working Group prediction) 2910 PGA43 Putative GPI-anchored protein of unknown function 1714 PGA44 Putative GPI-anchored protein of unknown function 2451 PGA45 Cell wall protein; putative GPI-anchor; downregulated in core caspofungin response; Hog1p-induced; regulated by Ssn6p; Mob2p-dependent hyphal regulation; possibly spurious ORF (Annotation Working Group prediction) 3638 PGA46 Putative GPI-anchored protein of unknown function 6321 PGA48 Putative GPI-anchored protein of unknown function; similar to S. cerevisiae Spi1p, which is induced at stationary phase; transcriptionally regulated by iron; expression greater in high iron 4404 PGA49 Putative GPI-anchored protein of unknown function 3693 PGA5 Putative GPI-anchored protein; fungal-specific (no human or murine homolog) 1824 PGA50 Putative GPI-anchored protein of unknown function 1911 PGA52 Putative GPI-anchored protein of unknown function; fluconazole-induced 4651 PGA53 Putative GPI-anchored protein of unknown function; greater mRNA abundance observed in a cyr1 homozygous null mutant than in wild type 2685 PGA54 Putative GPI-anchored protein; hyphal induced; Hog1p-downregulated; induced in a cyr1 or efg1 homozygous null mutant; shows colony morphology-related gene regulation by Ssn6p; upregulated in an RHE model 207 PGA55 Putative GPI-anchored protein of unknown function; filament induced; regulated by Nrg1p, Tup1p; possibly transcriptionally regulated upon hyphal formation 1105.2 PGA56 Regulator of sorbose utilization; putative GPI-anchor; predicted helix-loop helix domain; hyphal induced; induced during cell wall regeneration; shows colony morphology-related gene regulation by Ssn6p; transcription activated by Tbf1p 4689 PGA57 Putative GPI-anchored protein of unknown function 4334 PGA58 Putative GPI-anchored protein of unknown function; transcription is positively regulated by Tbf1p 2767 PGA59 Putative GPI-anchored protein of unknown function; shows colony morphology-related gene regulation by Ssn6p 4765 PGA6 Putative GPI-anchored cell-wall protein of unknown function; similar to S. cerevisiae Ccw12p/Ylr110cp; transcriptionally regulated by iron; expression greater in high iron; upregulated upon Als2p depletion 5588 PGA60 Putative GPI-anchored protein of unknown function; hyphal-induced expression 5762 PGA61 Putative GPI-anchored protein of unknown function; possibly spurious ORF (Annotation Working Group prediction) 2765 PGA62 Putative GPI-anchored protein; fluconazole-induced; transcriptionally regulated by iron; expression greater in high iron; induced during cell wall regeneration; Cyr1p or Ras1p downregulated; transcription is positively regulated by Tbf1p 6217 PGA63 Putative protein of unknown function 5635 PGA7 Protein described as a putative precursor of a hyphal surface antigen; putative GPI-anchor; induced by ciclopirox olamine, ketoconazole, or by Rim101p at pH 8; regulated during planktonic growth; induced during cell wall regeneration 3888 PGI1 Protein described as glucose-6-phosphate isomerase, enzyme of glycolysis; antigenic in human; regulated by Efg1p; induced in biofilm, upon adherence to polystyrene; downregulated in the presence of human neutrophils, upon phagocytosis 3651 PGK1 Phosphoglycerate kinase; enzyme of glycolysis; localizes to cell wall and to cytoplasm; antigenic during murine or human systemic infection; biofilm, Hog1p, GCN-induced; downregulated upon phagocytosis; possible N-glycosylation at N349 2841 PGM2 Protein not essential for viability; similar to S. cerevisiae Pgm2p, which is phosphoglucomutase 234 PHA2 Predicted ORF in Assemblies 19, 20 and 21; decreased expression observed in an ssr1 homozygous null mutant 6944 PHB1 Protein described as prohibitin; identified in detergent-resistant membrane fraction (possible lipid raft component); predicted N-terminal acetylation 2079 PHHB Transposon mutation affects filamentous growth 7016 PHM5 Protein not essential for viability; similar to S. cerevisiae Phm5p, which is a vacuolar endopolyphosphatase with a role in phosphate metabolism 2170 PHM7 Putative transporter; fungal-specific (no human or murine homolog); Hog1p-downregulated; downregulated in response to 17-beta-estradiol, ethynyl estradiol 4424 PHO100 Putative inducible acid phosphatase; DTT-extractable and observed in culture supernatant under low-phosphate conditions; slight effect on murine virulence; induced on biofilm formation; virulence-group-correlated expression; N-glycosylated 3754 PHO111 Protein described as a constitutive acid phosphatase; transcription is negatively regulated by Rim101p; DTT-extractable; N-glycosylated; merged with orf19.2619 in Assembly 20 3727 PHO112 Protein described as a constitutive acid phosphatase; transcription is negatively regulated by Rim101p; DTT-extractable; N-glycosylated 2619 PHO113 Protein described as a constitutive acid phosphatase; transcription is negatively regulated by Rim101p; DTT-extractable; N-glycosylated 4584 PHO114 Acid phosphatase, transcriptionally activated by Mnl1p under weak acid stress 1405 PHO13 Transcription is regulated upon yeast-hyphal switch 4444 PHO15 Protein described as 4-nitrophenyl phosphatase; hyphal downregulated; induced in core stress response; induced by heavy metal (cadmium) stress via Hog1p 1759 PHO23 Protein not essential for viability; similar to S. cerevisiae Pho23p, which is a probable component of the Rpd3 histone deacetylase complex 984 PHO8 Protein of unknown function; transcription is positively regulated by Rim101p; regulated by Tsa1p, Tsa1Bp in minimal media at 37 deg; possibly adherence-induced 7475 PHO81 Predicted ORF in Assemblies 19, 20 and 21; possibly adherence-induced 655 PHO84 Protein similar to high-affinity phosphate transporters; expression is regulated upon white-opaque switching or biofilm formation; Hog1p, ciclopirox olamine or alkaline induced; caspofungin or stress repressed; upregulated in RHE model 6846 PHO85 Functional homolog of S. cerevisiae Pho85p, which is a cyclin-dependent kinase that regulates processes including transcription of PHO genes involved in phosphate metabolism; gene has intron 2199 PHO86 Predicted ORF in Assemblies 19, 20 and 21; possibly adherence-induced 2454 PHO87 Protein similar to phosphate permeases; transcription is negatively regulated by Rim101p at pH 8; expression is regulated upon white-opaque switching; caspofungin repressed; biofilm-regulated; virulence-group-correlated expression 7327 PHO88 Putative role in phosphate transport; biofilm-regulated expression; amphotericin B repressed 4599 PHO89 Putative phosphate permease; expression is regulated upon white-opaque switching; alkaline upregulated by Rim101p; induced upon biofilm formation; possibly adherence-induced 3663 PHO91 Putative low-affinity phosphate transporter; fungal-specific (no human or murine homolog) 3829 PHR1 Glycosidase of cell surface; may act on cell-wall beta-1,3-glucan prior to beta-1,6-glucan linkage; E169 and E270 at active site; role in systemic but not vaginal virulence (neutral, not low pH); high pH or filamentation induced 6081 PHR2 Glycosidase; role in cell wall structure; may act on beta-1,3-glucan prior to beta-1,6-glucan linkage; role in vaginal but not systemic virulence (low pH, not neutral); low pH, high iron, fluconazole induced; Rim101p-downregulated at pH 8 377 PHR3 Predicted ORF in Assemblies 19, 20 and 21; fungal-specific (no human or murine homolog) 6133 PIF1 Decreased transcription is observed upon fluphenazine treatment 3199 PIKA Putative phosphatidylinositol kinase; gene is located within the MTLa mating-type-like locus 10711 PIKALPHA Putative phosphatidylinositol kinase; gene is located within the MTLalpha mating-type-like locus 778 PIL1 Echinocandin-binding protein; localizes to cell surface of hyphae, but not yeast-form cells; biofilm induced; fungal-specific (no human or murine homolog) 2534 PIN4 Protein with similarity to S. cerevisiae Pin4p; transposon mutation affects filamentous growth 5797 PI-PLC Phosphatidylinositol (PtdIns)-specific phospholipase C (PI-PLC); predicted type 2 membrane protein; role in, and regulated by, filamentation, Nrg1p and Tup1p; no mouse systemic virulence role; orf19.5797 and orf19.1586 are almost identical 220 PIR1 Structural protein of cell wall; 1,3-beta-glucan-linked; O-glycosylated by Pmt1p; N-mannosylated; tandem repeats; heterozygous mutant has cell wall defects; hyphal repressed; Hog1p, fluconazole, hypoxia induced; iron, Efg1p, Plc1p regulated 2783 PIR32 Protein described as putative cell wall structural component; macrophage-induced gene 5901 PKC1 Protein kinase C; functional homolog of S. cerevisiae Pkc1p; mutant has abnormal yeast-form cell morphology and increased cell lysis; activated by phosphatidylserine; target of antifungal, cercosporamide; R400P mutant is activated 689 PLB1 Phospholipase B; required for wild-type host cell penetration and for wild-type virulence in mouse model of systemic infection; Hog1p-induced; predicted signal sequence, N-glycosylation, and possible Y phosphorylation site, not GPI anchor 690 PLB2 Putative phospholipase B; conserved catalytic region; 6 putative N-glycosylation motifs; predicted secretion signal; no GPI anchor predicted; fungal-specific (no human or murine homolog) 6594 PLB3 Putative secreted phospholipase B; similar to S. cerevisiae Plb3p; putative GPI-anchor; fungal-specific (no human or murine homolog); transcription is positively regulated by Tbf1p 1443 PLB4 Putative phospholipase B; putative GPI-anchor; Hog1p-induced; regulated by Ssn6p; repressed during cell wall regeneration; merged with orf19.1442 in Assembly 20 1442 PLB4.5 Putative phospholipase B; Hog1p-induced; regulated by Ssn6p; putative GPI-anchor; repressed during cell wall regeneration; clade-associated gene expression 5102 PLB5 Putative phospholipase B, fungal-specific (no human or murine homolog); null mutation eliminates cell-associated phospholipase A2 activity and attenuates virulence; putative GPI anchor 5506 PLC1 Phosphoinositide-specific phospholipase C (PI-PLC), delta-form; essential; roles in stress resistance, hyphal growth; upregulated in biofilm; predicted N-linked glycosylation; lacks conserved EF-hand domain 1161 PLD1 Phospholipase D1; required for phosphatidic acid and for most diacylglycerol production; required for wild-type mouse virulence, but not rat oral virulence; mutant defect in hyphal growth on solid substrates; similar to S. cerevisiae Spo14p 5383 PMA1 Plasma membrane H(+)-ATPase; highly expressed, comprising 20-40% of total plasma membrane protein; abundance increases at stationary phase transition; fluconazole induced; caspofungin repressed; upregulated in RHE model 1727 PMC1 Vacuolar calcium P-type ATPase; transcription is regulated by calcineurin and fluconazole; mutant shows increased resistance to fluconazole or lithium, and increased sensitivity to calcium 1390 PMI1 Phosphomannose isomerase; cell wall biosynthesis enzyme; drug target; functional homolog of S. cerevisiae and E. coli phosphomannose isomerase; Gcn4p-regulated; repressed by 3-AT; induced on adherence to polystyrene, phagocytosis 2937 PMM1 Phosphomannomutase; enzyme of O- and N-linked mannosylation; interconverts mannose-6-phosphate and mannose-l-phosphate; functional homolog of S. cerevisiae Sec53p; antigenic during murine systemic infection 7089 PMR1 Putative secretory pathway P-type Ca2+/Mn2+-ATPase; required for protein glycosylation and cell wall maintenance; required for hyphal tip oscillation in semisolid substrate; putative ortholog of S. cerevisiae PMR1 1605 PMS1 Protein described as DNA mismatch repair factor; ortholog of S. cerevisiae PMS1 which is an ATP-binding protein involved in DNA mismatch repair 5171 PMT1 Protein mannosyltransferase, required for virulence in mouse systemic infection and for adhesion to epithelial cells; has a role in hyphal growth and drug sensitivity; Als1p, Sec20p, Kre9p, Pir1p are substrates; one of 5 PMT family members 6812 PMT2 Essential protein mannosyltransferase with roles in hyphal growth and drug sensitivity; member of the PMT family which includes Pmt1p, Pmt2p, Pmt4p, Pmt5p, and Pmt6p; induced during cell wall regeneration 4109 PMT4 Protein mannosyltransferase required for normal cell wall composition and full virulence in mouse systemic infection; has roles in hyphal growth and drug sensitivity; one of 5 PMT family members; Axl2p is a substrate 7549 PMT5 Protein mannosyltransferase with an unknown role, expressed at extremely low levels; not required for wild-type hyphal growth, drug resistance, or virulence in mouse systemic infection; one of five PMT family members 3802 PMT6 Protein mannosyltransferase, required for virulence in mouse systemic infection and for adhesion to endothelium; has a role in hyphal growth signaling and hygromycin B sensitivity; not a major contributor to overall cellular PMT activity 6684 PNC1 Putative nicotinamidase, involved in NAD salvage pathway; decreased transcription is observed in an azole-resistant strain that overexpresses MDR1 1560 POB3 Protein similar to S. cerevisiae Pob3p, which is involved in chromatin assembly and disassembly; transposon mutation affects filamentous growth 5873 POL1 Protein described as DNA directed DNA polymerase alpha; RNA abundance regulated by cell cycle, tyrosol and cell density 2365 POL2 Protein described as DNA polymerase epsilon; transcriptionally induced by interaction with macrophage; transcription is regulated by Tup1p; periodic mRNA expression, peak at cell-cycle G1/S phase 5182 POL3 Large subunit of DNA polymerase III; partially complements defects of an S. cerevisiae cdc2 mutant; differing reports about periodic (G1/S) or non-periodic mRNA expression through cell cycle 4616 POL30 Similar to proliferating cell nuclear antigen (PCNA); RNA abundance regulated by tyrosol and cell density; transcriptionally induced by interaction with macrophages; flucytosine induced; detected by mass spec in stationary phase culture 2465 POL32 Predicted ORF in Assemblies 19, 20 and 21; cell-cycle regulated periodic mRNA expression 5597 POL5 Predicted ORF in Assemblies 19, 20 and 21; induced upon biofilm formation 6078 POL93 Predicted ORF in retrotransposon Tca8 with similarity to the Pol region of retrotransposons encoding reverse transcriptase, protease and integrase; downregulated in response to ciclopirox olamine; induced upon biofilm formation 7657 POP3 Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins 5567 POP4 Protein likely to be essential for growth, based on an insertional mutagenesis strategy; similar to S. cerevisiae Pop4p, which is a subunit of both RNase MRP and nuclear RNase P; filament induced; regulated by Nrg1p, Tup1p 1042 POR1 Mitochondrial outer membrane porin; in detergent-resistant membrane fraction (possible lipid raft component); antigenic in human, mouse; flucytosine-, macrophage-, farnesol- induced; fluconazole, caspofungin repressed 6800 POS5 Protein likely to be essential for growth, based on an insertional mutagenesis strategy; similar to S. cerevisiae Pos5p, which is a mitochondrial NADH kinase involved in the oxidative stress response 7520 POT1 Putative peroxisomal 3-oxoacyl CoA thiolase; transcription is regulated by Nrg1p and Mig1p; farnesol regulated 2046 POT1-2 Putative peroxisomal 3-ketoacyl CoA thiolase 5723 POX1 Predicted acyl-CoA oxidase; expression is regulated upon white-opaque switching; upregulated upon phagocytosis 1652 POX1-3 Predicted acyl-CoA oxidase; farnesol regulated; protein detected by mass spec in stationary phase cultures 3330.3 POX18 Protein not essential for viability; similar to Candida maltosa Pox18p, which is a peroxisomal protein; Assembly 21 sequence was updated based on comparative genome analysis and new sequence data, and allelic orf19.10841 was reinstated 1459 PPE1 Protein similar to S. cerevisiae Ppe1p; shows genetic interaction with some genes involved in diploid filamentous growth and haploid invasive growth in S. cerevisiae 3774 PPG1 Putative protein phosphatase of the Type 2A-related family (serine/threonine-specific), similar to S. cerevisiae Ppg1p 1683 PPH21 Putative protein phosphatase of the Type 2A-related family (serine/threonine-specific), similar to S. cerevisiae Pph21p; caspofungin repressed 4405 PPS1 Putative dual specificity protein phosphatase, similar to S. cerevisiae Pps1p; mutant shows virulence defect 1673 PPT1 Protein described as serine/threonine phosphatase; transcriptionally regulated by iron; expression greater in high iron 726 PPZ1 Putative protein phosphatase of the Type 1 family (serine/threonine-specific), similar to S. cerevisiae Ppz1p; predicted ORF in Assemblies 19, 20 and 21 5793 PR26 Protein with similarity to proteasomal 26S regulatory subunit of S. cerevisiae, H. sapiens, Methanobacterium thermoautotrophicum (Archaebacterium) 3111 PRA1 Mediates leukocyte adhesion, induces migration; binds integrin alphaMbeta2; immunogenic in mouse; at cell surface; produced at ambient pH; Rim101p induced; 17-beta-estradiol, ethynyl estradiol downregulated 2242 PRB1 Putative endoprotease B; regulated by heat, carbon source (GlcNAc-induced), nitrogen, macrophage response, human neutrophils; putative D200-H232-S389 catalytic triad; similar to (but does not replace) S. cerevisiae vacuolar B protease Prb1p 4135 PRC2 Protein described as a carboxypeptidase; upregulated in the presence of human neutrophils 2474 PRC3 Transcription is regulated by Nrg1p and Mig1p; regulated by Gcn2p and Gcn4p 434 PRD1 Transcription is regulated by Nrg1p, Mig1p, and Tup1p; Hog1p-induced 4025 PRE1 Upregulated by Rim101p at acid pH; flucytosine induced; amphotericin B repressed 6582 PRE10 Alpha7 (C8) subunit of the 20S proteasome; multiple phosphorylated residues; transcription is induced upon filamentous growth 2233 PRE2 Protein described as beta-5 subunit of proteasome; macrophage-induced protein 6991 PRE3 Protein described as beta-1 subunit of proteasome; macrophage-induced protein; regulated by Gcn2p and Gcn4p 7178 PRE5 Alpha6 subunit of the 20S proteasome; regulated by Gcn4p; induced in response to amino acid starvation (3-aminotriazole treatment) 544.1 PRE6 Protein described as alpha-4 subunit of proteasome; reported as macrophage-induced protein and macrophage/pseudohyphal-repressed gene; regulated by Gcn2p and Gcn4p; removed from/reinstated in Assembly 20 (see Locus History) 7335 PRE8 Protein described as alpha-2_sc subunit of proteasome; macrophage-induced protein; regulated by Gcn2p and Gcn4p; transcription is positively regulated by Tbf1p; protein detected by mass spec in stationary phase cultures 350 PRE9 Alpha3 (C9) subunit of the 20S proteasome; transcription is regulated by Mig1p 2885 PRI2 Gene adjacent to CDC68; divergently transcribed with CDC68 669 PRM1 Protein induced during the mating process 2508 PRM9 Protein not essential for viability; similar to S. cerevisiae Prm9p, which may bind to COPII coated vesicles 2467 PRN1 Protein with similarity to pirins; increased transcription is observed upon benomyl treatment and in response to alpha pheromone in SpiderM medium; transcriptionally activated by Mnl1p under weak acid stress 2463 PRN2 Predicted ORF in Assemblies 19, 20 and 21; similar to pirin 2462 PRN3 Predicted ORF in Assemblies 19, 20 and 21; similar to pirin; transcriptionally activated by Mnl1p under weak acid stress 2461 PRN4 Protein with similarity to pirins; increased transcription is observed upon benomyl treatment 7638 PRO1 Transcription is regulated by Nrg1p; regulated by Gcn2p and Gcn4p 6779 PRO2 Predicted ORF in Assemblies 19, 20 and 21; regulated by Gcn2p and Gcn4p 5650 PRO3 Protein induced during the mating process; alkaline upregulated 4351 PRP12 Predicted ORF from Assembly 19; fungal-specific (no human or murine homolog); merged with orf19.4379 in Assembly 20 4379 PRP13 Predicted ORF in Assemblies 19, 20 and 21; fungal-specific (no human or murine homolog) 4033 PRP22 Protein described as an RNA-dependent ATPase; induced upon adherence to polystyrene; transcriptionally activated by Mnl1p under weak acid stress 1492 PRP39 Putative component of the U1 snRNP, involved in splicing; ortholog of S. cerevisiae PRP39; predicted ORF in Assemblies 19, 20 and 21 4374 PRP42 Putative component of the U1 snRNP, involved in splicing; ortholog of S. cerevisiae PRP42; predicted ORF in Assemblies 19, 20 and 21 6831 PRP5 Protein described as a pre-mRNA processing RNA-helicase; induced upon adherence to polystyrene 6442 PRP8 Protein similar to S. cerevisiae Prp8p; transcription is repressed in response to alpha pheromone in SpiderM medium 1341 PRR2 Predicted ORF in Assemblies 19, 20 and 21; mutation confers resistance to 5-fluorocytosine (5-FC) 2532 PRS Putative prolyl-tRNA synthetase; monofunctional Class II synthetase; gene is constitutively expressed 1575 PRS1 Phosphoribosylpyrophosphate synthetase; enzyme of purine, pyrimidine, histidine, and tryptophan biosynthesis; essential; flucytosine induced; macrophage/pseudohyphal-induced 2193 PRS5 Predicted ORF in Assemblies 19, 20 and 21; downregulated during core stress response 6584 PRT1 Putative translation initiation factor; mutation confers hypersensitivity to roridin A and verrucarin A; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 5180 PRX1 Protein described as a putative cysteine peroxidase; transcriptionally induced by interaction with macrophage; fluconazole induced; Fkh2p-downregulated; caspofungin repressed 2787 PRY1 Transcription is opaque specific; transcription is repressed in response to alpha pheromone in SpiderM medium 4943 PSA2 Predicted ORF in Assemblies 19, 20 and 21; macrophage-downregulated gene; protein detected by mass spec in stationary phase cultures 6910 PSF1 Predicted ORF in Assemblies 19, 20 and 21 57 PSF2 Predicted ORF in Assemblies 19, 20 and 21 7065 PSF3 Predicted ORF in Assemblies 19, 20 and 21; cell-cycle regulated periodic mRNA expression 5362 PSO2 Predicted ORF in Assemblies 19, 20 and 21; expressed in opaque or white MTLa/MTLa or MTLalpha/MTLalpha, but not MTLa/MTLalpha cells; telomere-proximal gene; mutation does not affect white-to-opaque phenotypic switching 671 PSP1 Protein repressed during the mating process 2241 PST1 Protein described as 1,4-benzoquinone reductase; biofilm induced; hyphal-induced expression, regulated by Cyr1p, Ras1p, Efg1p, Nrg1p, Rfg1p, Tup1p 3612 PST2 Putative NADH:quinone oxidoreductase; similar to 1,4-benzoquinone reductase; immunogenic in mice; benomyl treatment induces transcription; oxidative stress-induced via Cap1p; fungal-specific (no human/murine homolog), farnesol-downregulated 5285 PST3 Putative flavodoxin; biofilm induced; fungal-specific (no human or murine homolog); protein detected by mass spec in stationary phase cultures 3685 PSY2 Predicted ORF in Assemblies 19, 20 and 21; macrophage-induced gene 4785 PTC1 Putative protein phosphatase of the Type 2C-related family (serine/threonine-specific), similar to S. cerevisiae Ptc1p; mutant shows virulence defect 2538 PTC2 Putative protein phosphatase of the Type 2C-related family (serine/threonine-specific), similar to S. cerevisiae Ptc2p and Ptc3p; mutant shows virulence defect 6638 PTC4 Protein described as a serine/threonine phosphatase, type PP2C; decreased expression in hyphae compared to yeast-form cells 6376 PTC5 Putative protein phosphatase of the Type 2C-related family (serine/threonine-specific), similar to S. cerevisiae Ptc5p; mutant shows virulence defect 3705 PTC6 Putative protein phosphatase of the Type 2C-related family (serine/threonine-specific), similar to S. cerevisiae Ptc6p; mutant shows virulence defect 5661 PTC7 Protein phosphatase, type 2C; has S/T phosphatase activity, Mn2+/Mg2+ dependent; predicted membrane-spanning segment and mitochondrion-targeting signal 4698 PTC8 Predicted type 2C protein phosphatase, serine/threonine-specific; required for hyphal growth; induced under stress 4232 PTH1 Putative gluconate transport protein; antigenic during human oral infection 4231 PTH2 Predicted ORF in Assemblies 19, 20 and 21; constitutive expression independent of MTL or white-opaque status 3415 PTK2 Putative protein kinase of polyamine import; mutation confers hypersensitivity to high concentrations of tunicamycin; upregulated in biofilm 6365 PTP1 Protein not essential for viability; similar to S. cerevisiae Ptp1p, which is a protein tyrosine phosphatase 7610 PTP3 Protein not essential for viability; similar to S. cerevisiae Ptp3p, which is a protein tyrosine phosphatase; hyphal induced; alkaline upregulated; regulated by Efg1p, Ras1p, cAMP pathways 6937 PTR2 Putative oligopeptide transporter; regulated by Stp2p and Stp3p; transcriptionally induced upon phagocytosis by macrophage; downregulated by Rim101p at pH 8 4535 PTR3 Protein not essential for viability; similar to S. cerevisiae Ptr3p, which is a sensor of external amino acids; increased expression observed in an ssr1 homozygous null mutant 1795 PUF3 Protein not essential for viability; similar to S. cerevisiae Puf3p, which is an mRNA-binding protein involved in RNA catabolism 7605 PUP1 Predicted ORF in Assemblies 19, 20 and 21; macrophage/pseudohyphal-repressed 709 PUP2 Alpha5 subunit of the 20S proteasome; macrophage/pseudohyphal-repressed; regulated by Gcn2p and Gcn4p; protein detected by mass spec in exponential and stationary phase cultures 1336 PUP3 Predicted ORF in Assemblies 19, 20 and 21; macrophage/pseudohyphal-repressed 1954 PUS4 Transcription is regulated by Nrg1p, Mig1p, and Tup1p 1753 PUS7 Protein similar to S. cerevisiae tRNA modification protein; induced upon biofilm formation 4274 PUT1 Alkaline upregulated by Rim101p 3974 PUT2 Alkaline upregulated; protein detected by mass spec in exponential and stationary phase cultures 2945 PUT4 Putative proline permease; fungal-specific (no human or murine homolog); repressed during the mating process 4640 PWP1 Predicted ORF in Assemblies 19, 20 and 21; downregulated in core stress response 3276 PWP2 Predicted ORF in Assemblies 19, 20 and 21; downregulated during core stress response; decreased expression in response to prostaglandins; physically interacts with TAP-tagged Nop1p 7500 PXA1 Putative peroxisomal, half-size adrenoleukodystrophy protein (ALD or ALDp) subfamily ABC family transporter 5255 PXA2 Putative peroxisomal, half-size adrenoleukodystrophy protein (ALD or ALDp) subfamily ABC transporter; Gcn4p-regulated 1655 PXP2 Putative acyl-CoA oxidase; enzyme of fatty acid beta-oxidation; induced during macrophage infection; expression is opaque specific; has putative peroxisome targeting signal 789 PYC2 Putative pyruvate carboxylase, binds to biotin cofactor; up-regulated in mutant lacking the Ssk1p response regulator protein, upon benomyl treatment, or in an azole-resistant strain overexpressing MDR1 2644 QCR2 Protein described as ubiquinol-cytochrome-c reductase; antigenic in human; transcriptionally induced by interaction with macrophage; repressed by nitric oxide; in detergent-resistant membrane fraction (possible lipid raft component) 5629 QCR7 Protein described as ubiquinol-cytochrome-c reductase, subunit 7 4490.2 QCR8 ORF Predicted by Annotation Working Group; shows colony morphology-related gene regulation by Ssn6p; macrophage/pseudohyphal-induced 2707.1 QCR9 ORF Predicted by Annotation Working Group; shows colony morphology-related gene regulation by Ssn6p 508 QDR1 Putative transporter of antibiotic resistance; transcription is regulated by Nrg1p and Tup1p; caspofungin repressed; expression is regulated upon white-opaque switching 6237 RAC1 G-protein of RAC subfamily; required for embedded filamentous growth, but not for serum-induced hyphal growth; dynamic localization at plasma membrane; similar to, but not interchangeable with, Cdc42p; lacks S. cerevisiae homolog 5318 RAD1 Transcription is regulated by Nrg1p; macrophage-induced gene 2469 RAD10 Ortholog of S. cerevisiae RAD10, an endonuclease involved in nucleotide excision repair; null mutant is extremely sensitive to UV irradiation; transcription is downregulated in alkaline conditions 6517 RAD14 Transcription is regulated upon yeast-hyphal switch; flucytosine repressed 2969 RAD16 Protein similar to S. cerevisiae Rad16p; flucytosine induced 1324 RAD2 Ortholog of S. cerevisiae RAD2, nucleotide excision repair nuclease; null mutant is extremely sensitive to UV irradiation; transcription is upregulated upon interaction with macrophages 1494 RAD23 Predicted ORF in Assemblies 19, 20 and 21 866 RAD32 Protein similar to S. cerevisiae protein with role in nucleotide excision repair; down-regulation associated with azole resistance 1648 RAD50 Protein described as DNA double-strand break repair factor; involved in response to oxidative stress and drug resistance 3752 RAD51 Predicted ORF in Assemblies 19, 20 and 21; flucytosine induced; slow growth and increased white-to-opaque switching frequency in null mutant 4208 RAD52 Required for homologous DNA recombination, repair of UV- or MMS-damaged DNA, telomere length, UV-induced LOH; constitutive expression, MMS-induced; weakly complements S. cerevisiae rad52 mutant; slow growth, increased white-to-opaque switch 6936 RAD53 Protein involved in regulation of DNA-damage-induced filamentous growth; putative component of cell cycle checkpoint; ortholog of S. cerevisiae Rad53p, protein kinase required for cell-cycle arrest in response to DNA damage 5004 RAD54 Protein similar to S. cerevisiae Rad54p, which is a DNA-dependent ATPase involved in DNA repair; induced under hydroxyurea treatment 2174 RAD57 Essential protein; described as having role in DNA recombination, repair; transcriptionally induced by interaction with macrophage; transcription is regulated by Nrg1p, Mig1p, and Tup1p; S. cerevisiae ortholog is essential 2630 RAD59 Protein similar to S. cerevisiae Rad59p; N-terminal similarity with Rad52p 7195 RAD6 Negative regulator of hyphal growth; required for wild-type UV resistance; acts in pathway with Efg1p ; functional homolog of S. cerevisiae Rad6p; transcription is UV-induced, slightly repressed during hyphal growth; gene has two introns 1493 RAD7 Protein similar to S. cerevisiae Rad7p, which is a subunit of the Nucleotide Excision Repair Factor 4; induced under hydroxyurea treatment 4275 RAD9 Protein involved in regulation of DNA-damage-induced filamentous growth; putative component of DNA damage checkpoint; ortholog of S. cerevisiae Rad9p; transcription is induced in response to alpha pheromone in SpiderM medium 5046 RAM1 Protein that acts in prenylation; transcription is alpha-factor induced; regulated in response to lovastatin and fluconazole 4817 RAM2 Alpha subunit of heterodimeric protein geranylgeranyltransferase type I and farnesyltransferase; a-specific transcription; lovastatin and fluconazole regulated; GGTase I enzyme binds zinc, is Mg-dependent; Cdc42p is GGTase I substrate 1773 RAP1 Protein similar to (but shorter than) S. cerevisiae Rap1p, a transcriptional regulator that binds telomeres and regulatory sequences; binds DNA; represses hyphal growth under yeast-favoring conditions 1760 RAS1 RAS signal transduction GTPase; regulates cAMP and MAP kinase pathways; role in hyphal induction, virulence, apoptosis, heat-shock sensitivity; nonessential; glutamine-rich C terminus; complements viability of S. cerevisiae ras1 ras2 mutant 5902 RAS2 Protein similar to S. cerevisiae Ras2p, which activates adenylate cyclase and is involved in pseudohyphal growth of S. cerevisiae; transposon mutation affects filamentous growth 4681 RAT1 5'-->3' exoribonuclease; similar to S. cerevisiae nuclear exoribonuclease Rat1p; suppresses S. cerevisiae kem1 mutant slow growth, mating defect, and haploid invasive growth defect 5561 RAV2 Protein similar to S. cerevisiae Rav2p, which is involved in acidification of the vacuole; transposon mutation affects filamentous growth 5903 RAX1 Protein described as having a possible role in bud site selection; hyphal-induced expression 3765 RAX2 Protein of unknown function; detected at yeast-form cell plasma membrane by mass spectrometry; transcription is filament induced and negatively regulated by Rim101p, Tup1p 5234 RBD1 Rhomboid-like protein; similar to putative intramembrane serine proteases; involved in filamentous growth; Gcn4p-regulated; caspofungin repressed 7218 RBE1 Putative cell wall protein; transcription is negatively regulated by Rim101p, Efg1p, Ssn6p; alkaline downregulated; predicted signal sequence, O-glycosylation; no GPI anchor predicted 5558 RBF1 Transcription factor; glutamine-rich activation domain; binds RPG-box DNA sequences; predominantly nuclear; antigenic during human oral infection; mutation causes accelerated induction of filamentous growth 6344 RBK1 Protein not essential for viability; similar to S. cerevisiae Rbk1p, which is a ribokinase 6452 RBP1 Peptidyl-prolyl cis-trans isomerase; rapamycin-binding protein; homozygous null mutation confers rapamycin resistance; regulated by Gcn4p; macrophage-induced protein; repressed in response to 3-AT; functional homolog of S. cerevisiae Rbp1p 535 RBR1 Glycosylphosphatidylinositol (GPI)-anchored cell wall protein required for filamentous growth at acidic pH; expression is repressed by Rim101p and activated by Nrg1p 532 RBR2 Cell wall protein; expression is repressed by Rim101p; expression is regulated upon white-opaque switching; transcription is repressed in response to alpha pheromone in SpiderM medium; macrophage-induced gene 5124 RBR3 Cell wall protein; expression is repressed by Rim101p 1327 RBT1 Putative cell wall protein with similarity to Hwp1p, required for virulence; predicted to be cell-wall attached and glycosylated; Tup1p repressed; serum, hyphal and alkaline induced; farnesol, alpha factor induced; Rfg1p-, Rim101p-regulated 6202 RBT4 Similar to plant pathogenesis-related proteins; required for virulence in mouse systemic, rabbit corneal infections; not required for filamentation; secretion signal; TUP1/RFG1/SSN6/HOG1 repressed; serum, hyphal, pheromone, alkaline-induced 5636 RBT5 GPI-anchored cell wall protein involved in hemoglobin utilization; expression is regulated by Rfg1p, Rim101p, Tbf1p, iron; repressed by Sfu1p, Hog1p, Tup1p; induced by serum, alkaline pH, ketoconazole, ciclopirox olamine 2681 RBT7 Protein with similarity to RNase T2 enzymes, has putative secretion signal; expression is Tup1p-repressed 3825 RCE1 Protein induced during the mating process 3211 RCF3 Transcription is induced upon filamentous growth 2268 RCK2 Predicted MAP kinase-activated protein kinase, similar to S. cerevisiae serine/threonine protein kinase Rck2p; induced by osmotic stress via Hog1p; macrophage/pseudohyphal-repressed; mutants are sensitive to rapamycin 1886 RCL1 Predicted ORF in Assemblies 19, 20 and 21; essential; downregulated during core stress response; S. cerevisiae ortholog is essential 3203 RCY1 Putative F-box protein involved in endocytic membrane traffic and/or recycling; fungal-specific (no human or murine homolog) 5367 RDH54 Protein described as having role in DNA recombination, repair; transcriptionally induced by interaction with macrophage 5968 RDI1 Protein similar to S. cerevisiae Rdi1p, an inhibitor of Rho-GDP dissociation; transposon mutation affects filamentous growth; farnesol-, filament-induced; regulated by Nrg1p, Tup1p 2005 REG1 Predicted ORF in Assemblies 19, 20 and 21; macrophage/pseudohyphal-induced; possibly transcriptionally regulated upon hyphal formation 59 REI1 Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins 7521 REP1 Protein involved in negative regulation of MDR1 transcription; mutants show increased resistance to azole drugs 4236 RET2 Protein that interacts with Crk1p in the two-hybrid system; potential ortholog of S. cerevisiae Ret2p 7389 REV3 Protein not essential for viability; similar to S. cerevisiae Rev3p, which is a subunit of DNA polymerase zeta 1466 REX2 Predicted ORF in Assemblies 19, 20 and 21; transcription is upregulated in both intermediate and mature biofilms 2093 RFA1 Protein described as DNA replication factor A; RNA abundance regulated by cell cycle, tyrosol and cell density 2267 RFA2 Protein described as DNA replication factor A; RNA abundance regulated by cell cycle, tyrosol and cell density 6891 RFC1 Protein likely to be essential for growth, based on an insertional mutagenesis strategy; similar to S. cerevisiae Rfc1, which is a subunit of DNA replication factor C 7035 RFC2 Predicted ORF in Assemblies 19, 20 and 21; periodic mRNA expression, peak at cell-cycle G1/S phase 7658 RFC4 Predicted ORF in Assemblies 19, 20 and 21; flucytosine induced; periodic mRNA expression, peak at cell-cycle G1/S phase 2029 RFC5 Predicted ORF in Assemblies 19, 20 and 21; periodic mRNA expression, peak at cell-cycle G1/S phase 6078.1 RFC52 ORF Predicted by Annotation Working Group; periodic mRNA expression, peak at cell-cycle G1/S phase 2823 RFG1 Transcriptional regulator of filamentous growth and hyphal genes; acts in Tup1p-dependent and -independent pathways; binds DNA; has HMG domain; not transcriptionally regulated by oxygen or serum; not responsible for hypoxic repression 3865 RFX1 Predicted ORF in Assemblies 19, 20 and 21; similar to S. cerevisiae Rfx1p (DNA-binding transcriptional repressor of DNA damage response); has RFX domain 4590 RFX2 Transcriptional repressor; regulator of filamentation, response to DNA damage, adhesion, virulence in murine mucosal, systemic infections; RFX domain; regulated by Nrg1p, UV-induced; partially complements S. cerevisiae rfx1 mutant defects 4593 RGA2 Putative GTPase-activating protein (GAP) for Rho-type GTPase Cdc42p; involved in cell signaling pathways that control cell polarity; similar to S. cerevisiae Rga2p; induced upon low-level peroxide stress 2443 RGD1 Protein described as a GTPase activator; transcriptionally regulated by iron; expression greater in low iron; alkaline upregulated 2626 RGD2 Putative GTPase activating protein; fungal-specific (no human or murine homolog); merged with orf19.729.1 in Assembly 20 729.1 RGD3 Putative Rho GTPase activating protein; fungal-specific (no human or murine homolog) 695 RGS2 Protein of RGS superfamily; not essential for viability; possibly spurious ORF (Annotation Working Group prediction) 2747 RGT1 Transcriptional repressor involved in the regulation of glucose transporter genes; has zinc-cluster; similar to S. cerevisiae Rgt1p 5994 RHB1 Putative small G protein from the Ras superfamily involved in cell wall integrity and control of filamentous growth under nitrogen starvation 54 RHD1 Putative beta-mannosyltransferase, required for the addition of beta-mannose to the acid-labile fraction of cell wall phosphopeptidomannan; member of a 9-gene family; transcriptionally regulated on yeast-hyphal and white-opaque switches 2668 RHD2 Predicted ORF in retrotransposon Tca4 with similarity to the Gag region encoding nucleocapsid-like protein; overlaps blocked reading frame orf19.2668.1; decreased expression in hyphae compared to yeast-form cells 5305 RHD3 Putative GPI-anchored protein that localizes to the cell wall; transcription is decreased upon yeast-hyphal switch; transcriptionally regulated by iron; expression greater in high iron; clade-associated gene expression 2843 RHO1 Small GTPase of Rho family; regulates beta-1,3-glucan synthesis activity and binds Gsc1p; essential; expected to be geranylgeranylated by geranylgeranyltransferase type I 3534 RHO3 Putative Rho family GTPase; possible substrate of protein farnesyltransferase and geranylgeranyltransferase type I; greater transcription in hyphal form than yeast form 5437 RHR2 Putative glycerol 3-phosphatase; roles in osmotic tolerance, glycerol accumulation in response to salt; regulated by macrophage, stress response, yeast-hyphal switch, pheromone, GCN4, HOG1, NRG1, TUP1; antigenic in murine systemic infection 4451 RIA1 Putative translation elongation factor; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 2862 RIB1 Putative GTP cyclohydrolase II; enzyme of riboflavin biosynthesis; fungal-specific (no human or murine homolog) 5228 RIB3 3,4-Dihydroxy-2-butanone 4-phosphate synthase; homodimeric enzyme of riboflavin biosynthesis; converts ribulose 5-phosphate to L-3,4-dihydroxy-2-butanone 4-phosphate; transcription regulated on yeast-hyphal switch, macrophage interaction 4024 RIB5 Putative riboflavin synthase; fungal-specific (no human or murine homolog); farnesol-downregulated; protein detected by mass spec in exponential and stationary phase cultures 6036 RIC1 Protein not essential for viability; similar to S. cerevisiae Ric1p, which is a guanyl-nucleotide exchange factor 2483 RIM1 Predicted ORF in Assemblies 19, 20 and 21; protein level decreased in stationary phase cultures 7247 RIM101 Transcription factor involved in alkaline pH response; required for alkaline-induced hyphal growth; role in virulence in mouse systemic infection; activated by C-terminal proteolytic cleavage; mediates both positive and negative regulation 791 RIM11 Protein not essential for viability; similar to S. cerevisiae Rim11p, which is a protein kinase involved in meiosis and sporulation 3995 RIM13 Probable protease involved in the pH response pathway, likely to mediate activation of the transcription factor Rim101p via C-terminal cleavage; required for alkaline pH-induced hyphal growth and for normal levels of chlamydospore formation 4499 RIM2 Protein similar to S. cerevisiae Rim2p; induced in response to alpha pheromone in SpiderM medium 4800 RIM20 Protein involved in the pH response pathway; binds to the transcription factor Rim101p and may serve as a scaffold to facilitate the C-terminal proteolytic cleavage that activates Rim101p; required for alkaline pH-induced hyphal growth 3176 RIM21 Protein involved in the pH response pathway; required for activation of the transcription factor Rim101p and for alkaline pH-induced hyphal growth; may function as a sensor of alkaline pH 6091 RIM8 Protein involved in the pH response pathway; required for activation of the transcription factor Rim101p and for alkaline pH-induced hyphal growth; shows colony morphology-related gene regulation by Ssn6p 101 RIM9 Protein required for alkaline pH response via the RIM101 signaling pathway; ortholog of S. cerevisiae RIM9 and A. nidulans palI 5893 RIP1 Protein described as subunit of ubiquinol cytochrome c-reductase; transcriptionally regulated by iron; expression greater in high iron; alkaline downregulated; repressed by nitric oxide 6727 RIT1 Putative initiator tRNA methionine ribosyltransferase; fungal-specific (no human or murine homolog) 4219 RIX7 Protein similar to S. cerevisiae Rix7p which is a putative ATPase of the AAA family required for ribosomal subunit export from the nucleus; mutation impairs hyphal growth and biofilm formation 1701 RKI1 Predicted ORF in Assemblies 19, 20 and 21 3034 RLI1 Member of RNase L inhibitor (RLI) subfamily of ABC family; predicted not to be a transporter 4662 RLM1 Putative transcription factor; required for wild-type resistance to cell wall perturbation, caspofungin treatment; regulates caspofungin induction of PGA13 4191 RLP24 Predicted ORF in Assemblies 19, 20 and 21; essential; S. cerevisiae ortholog is essential; heterozygous mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine) 4438 RME1 Protein similar to S. cerevisiae meiotic regulator Rme1p; white-specific transcription; upregulation correlates with clinical development of fluconazole resistance; transcription is not regulated during rat oral infection 2654 RMS1 Protein induced during the mating process 920 RMT2 Minor protein arginine methyltransferases (PRMT) involved in methylation of arginine residues 1649 RNA1 Predicted ORF in Assemblies 19, 20 and 21; protein level decreased in stationary phase cultures 5563 RNH1 Protein described as Ribonuclease H (RNAse H); hyphal-induced; flucytosine induced; similar to orf19.5564 (see Locus History) 6562 RNH35 Predicted ORF in Assemblies 19, 20 and 21; flucytosine induced 5779 RNR1 Protein similar S. cerevisiae Rnr1p, large subunit of ribonucleotide reductase; expression greater in low iron; transposon mutation affects filamentous growth; farnesol upregulated in biofilm; regulated by cell cycle, tyrosol, cell density 5801 RNR21 Protein described as similar to ribonucleoside-diphosphate reductase; regulated by tyrosol and cell density; transcription is upregulated in response to treatment with ciclopirox olamine; fluconazole or flucytosine induced 1868 RNR22 Protein described as ribonucleoside diphosphate reductase; shows colony morphology-related gene regulation by Ssn6p; RNA abundance regulated by tyrosol and cell density 5845 RNR3 Protein described as large subunit of ribonucleotide reductase; transcriptionally regulated by iron; expression greater in low iron 1509 ROD1 Protein not essential for viability; similar to S. cerevisiae Rod1p, which is a membrane protein with a role in drug tolerance; repressed by Rgt1p 906 ROM2 Predicted ORF in Assemblies 19, 20 and 21 6029 ROT1 Similar to S. cerevisiae Rot1p, which is involved in cell wall 1,6-beta-glucan biosynthesis; has predicted transmembrane region 974 ROT2 Alpha-glucosidase II, catalytic subunit, required for N-linked protein glycosylation and normal cell wall synthesis; alkaline downregulated 2287 RPA12 Protein described as DNA-directed RNA polymerase I; induced upon adherence to polystyrene 7062 RPA135 Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins 1839 RPA190 Predicted ORF in Assemblies 19, 20 and 21;flucytosine induced 6010.1 RPB11 ORF Predicted by Annotation Working Group; flucytosine induced 145 RPB4 Protein similar to S. cerevisiae Rpb4p, which is a component of RNA polymerase II; transposon mutation affects filamentous growth 3347 RPB7 Functional homolog of S. cerevisiae Rpb7p, an essential subunit of RNA Polymerase II; enhances hyperfilamentation of an S. cerevisiae rpb4 mutant; suppresses defects of S. cerevisiae rpb4 and ess1 mutants 6314 RPB8 Protein described as a subunit of RNA polymerases I, II, and III; regulated by Gcn4p; repressed in response to amino acid starvation (3-aminotriazole treatment); heterozygous null mutant exhibits resistance to parnafungin 7255 RPC10 Predicted ORF in Assemblies 19, 20 and 21; flucytosine induced 5360 RPC11 Predicted ORF in Assemblies 19, 20 and 21; downregulated in core caspofungin response 172 RPC19 Predicted ORF in Assemblies 19, 20 and 21; transcription is upregulated in both intermediate and mature biofilms 2831 RPC31 Predicted ORF in Assemblies 19, 20 and 21; repressed by nitric oxide; induced during infection of murine kidney, compared to growth in vitro; has murine homolog 3564 RPC40 Predicted ORF in Assemblies 19, 20 and 21; protein level decreased in stationary phase cultures 2715 RPC53 Predicted ORF in Assemblies 19, 20 and 21 2834 RPD3 Histone deacetylase; regulates frequency of white-to-opaque and opaque-to-white switching; greater expression in white cells than opaque cells; has conserved deacetylation motif 2667 RPF1 Predicted ORF in Assemblies 19, 20 and 21; essential for growth 3553 RPF2 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine) 6345 RPG1A Putative translation initiation factor; mutation confers hypersensitivity to roridin A and verrucarin A; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 2935 RPL10 Putative ribosomal protein; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases downregulated upon phagocytosis by murine macrophage; transcription regulated upon yeast-hyphal switch; intron in 5'-UTR 3465 RPL10A Predicted ribosomal protein; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 2232 RPL11 Predicted ribosomal protein; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage; colony morphology-related gene regulation by Ssn6p 1635 RPL12 Predicted ribosomal protein; downregulated in the presence of human whole blood or polymorphonuclear (PMN) cells; genes encoding cytoplasmic ribosomal subunits are downregulated upon phagocytosis by murine macrophage; Tbf1p-activated 2994 RPL13 Protein described as ribosomal subunit; antigenic during murine systemic infection; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 4931.1 RPL14 ORF Predicted by Annotation Working Group 493 RPL15A Putative ribosomal protein; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage; transcription is positively regulated by Tbf1p 6085 RPL16A Protein similar to S. cerevisiae ribosomal protein Rpl16Ap; transposon mutation affects filamentous growth; genes encoding cytoplasmic ribosomal subunits are downregulated upon phagocytosis by murine macrophage 4490 RPL17B Predicted ribosomal protein; mutation confers hypersensitivity to 5-FU, tubercidin (7-deazaadenosine); genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated on phagocytosis by macrophage 5982 RPL18 Predicted ribosomal protein; Plc1p-regulated, Tbf1p-activated; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 5904 RPL19A Predicted ribosomal protein; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 2309.2 RPL2 ORF Predicted by Annotation Working Group; shows downregulation in infected rabbit kidney in SC5314, but not NGY152, strain background 4632 RPL20B Predicted ribosomal protein; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage; intron in 5'-UTR 840 RPL21A Putative ribosomal protein; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 3504 RPL23A Putative ribosomal protein; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 3789 RPL24A Predicted ribosomal protein; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage; intron in 5'-UTR 687.1 RPL25 ORF Predicted by Annotation Working Group; shows colony morphology-related gene regulation by Ssn6p 5225.2 RPL27A Predicted ribosomal protein 2864.1 RPL28 Putative ribosomal protein; Plc1p-regulated; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 2310.1 RPL29 Ribosomal protein L29; transcription is induced upon germ tube formation; shows colony morphology-related gene regulation by Ssn6p; intron in 5'-UTR 1601 RPL3 Putative ribosomal protein; similar to S. cerevisiae Rpl3p; gene induced by ciclopirox olamine treatment; genes encoding cytoplasmic ribosomal subunits are downregulated upon phagocytosis by murine macrophage 3788.1 RPL30 Similar to S. cerevisiae L30 ribosomal subunit; pre-mRNA is alternatively spliced to productive and unproductive transcripts; splicing is temperature-regulated; colony morphology-related gene regulation by Ssn6p; regulated by Nrg1p, Tup1p 3415.1 RPL32 Predicted ribosomal protein 5964.2 RPL35 Protein described as a ribosomal protein; downregulation correlates with clinical development of fluconazole resistance; shows colony morphology-related gene regulation by Ssn6p 667.1 RPL37B Predicted ribosomal protein 2111.2 RPL38 Predicted ribosomal protein; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 827.1 RPL39 Ribosomal protein L39; transcription is induced upon germ tube formation; shows colony morphology-related gene regulation by Ssn6p 4684.2 RPL40B Protein with similarity to the ribosomal protein portion of S. cerevisiae Rpl40Bp; shows colony morphology-related gene regulation by Ssn6p; transcription is positively regulated by Tbf1p 4909.1 RPL42 ORF Predicted by Annotation Working Group; shows colony morphology-related gene regulation by Ssn6p 3942.1 RPL43A Downregulated in the presence of human whole blood or polymorphonuclear (PMN) cells; shows colony morphology-related gene regulation by Ssn6p 7217 RPL4B Putative ribosomal protein; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 6541 RPL5 Predicted ribosomal protein; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 3003.1 RPL6 Protein similar to S. cerevisiae Rpl6p, which is a ribosomal subunit; transposon mutation affects filamentous growth; translation-related genes are downregulated upon phagocytosis by murine macrophage 3867 RPL7 Putative ribosomal-related protein; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 2311 RPL82 Predicted ribosomal protein; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 6002 RPL8B Predicted ribosomal protein; transcription is regulated upon yeast-hyphal switch; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 236 RPL9B Predicted ribosomal protein; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage; repressed by nitric oxide 4956 RPN1 Predicted ORF in Assemblies 19, 20 and 21; regulated by Gcn2p and Gcn4p 4102 RPN10 Predicted ORF in Assemblies 19, 20 and 21; macrophage/pseudohyphal-repressed; regulated by Gcn2p and Gcn4p 5260 RPN2 Transcription is regulated by Mig1p; caspofungin repressed; regulated by Gcn2p and Gcn4p; gene used for strain identification by multilocus sequence typing 3054 RPN3 Predicted ORF in Assemblies 19, 20 and 21; amphotericin B repressed; oxidative stress-induced via Cap1p 1069 RPN4 DNA binding protein with Cys2-His2 zinc-finger; putative regulator of proteasome genes; DNA recognition sequence (GAAGGCAAAA) enriched in regions upstream of proteasome genes; induced in core stress response 4032 RPN5 Predicted ORF in Assemblies 19, 20 and 21; macrophage/pseudohyphal-repressed 1299 RPN6 Predicted ORF in Assemblies 19, 20 and 21; regulated by Gcn2p and Gcn4p 7286 RPN7 Predicted ORF in Assemblies 19, 20 and 21; regulated by Gcn2p and Gcn4p; protein detected by mass spec in exponential and stationary phase cultures 3168 RPN8 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to amphotericin B; transcription is regulated by Mig1p; regulated by Gcn2p and Gcn4p 7655 RPO21 Protein similar to S. cerevisiae Rpo21p, RNA polymerase II; transposon mutation affects filamentous growth 6041 RPO41 Predicted ORF in Assemblies 19, 20 and 21; downregulated during core stress response 7015 RPP0 Putative ribosomal protein; antigenic in mouse; biofilm induced; cytoplasmic ribosomal subunit, translation factor, and tRNA synthetase genes are downregulated upon phagocytosis by murine macrophage; transcription induced by Tbf1p 2992 RPP1A Conserved acidic ribosomal protein, likely to be involved in regulation of translation elongation; interacts with Rpp2Bp; one of four similar C. albicans ribosomal proteins (Rpp1Ap, Rpp1Bp, Rpp2Ap, Rpp2Bp) 7188 RPP1B Conserved acidic ribosomal protein, likely to be involved in regulation of translation elongation; interacts with Rpp2Ap; one of four similar C. albicans ribosomal proteins (Rpp1Ap, Rpp1Bp, Rpp2Ap, Rpp2Bp); transcription activated by Tbf1p 6403.1 RPP2A Conserved acidic ribosomal protein, likely involved in regulation of translation elongation; interacts with Rpp1Bp; one of four similar ribosomal proteins (Rpp1Ap, Rpp1Bp, Rpp2Ap, Rpp2Bp); CUG start codon; upstream uORFs; Tbf1p-activated 5928 RPP2B Conserved acidic ribosomal protein, likely to be involved in regulation of translation elongation; interacts with Rpp1Ap; one of four similar C. albicans ribosomal proteins (Rpp1Ap, Rpp1Bp, Rpp2Ap, Rpp2Bp); macrophage/pseudohyphal-induced 3002 RPS1 Probable ortholog of S. cerevisiae ribosomal protein Rp10 (Rps1Ap and Rps1Bp), elicits a host antibody response during infection; transcription is induced during active growth 2179.2 RPS10 Predicted ribosomal protein; downregulated in the presence of human whole blood or polymorphonuclear (PMN) cells 6785 RPS12 Protein described as acidic ribosomal protein S12; regulated by Gcn4p, activated by Tbf1p; repressed under amino acid starvation (3-aminotriazole treatment); protein abundance is affected by URA3 expression in the CAI-4 strain background 4193.1 RPS13 Putative ribosomal protein; ORF predicted by Annotation Working Group 6265.1 RPS14B Putative ribosomal protein; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage; transcription is positively regulated by Tbf1p 5927 RPS15 Putative ribosomal protein; macrophage/pseudohyphal-induced after 16 h; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 2994.1 RPS16A Macrophage/pseudohyphal-induced after 16 h 2329.1 RPS17B Putative ribosomal protein; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 7018 RPS18 Predicted ribosomal protein; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage; repressed by nitric oxide 5996.1 RPS19A Putative ribosomal protein; ORF Predicted by Annotation Working Group; protein level decreased in stationary phase cultures 6375 RPS20 Putative ribosomal protein; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage; transcription is positively regulated by Tbf1p 3334 RPS21 Predicted ribosomal protein; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage; transcription is positively regulated by Tbf1p 3325.3 RPS21B Protein described as similar to ribosomal protein S21; regulated by Nrg1p, Tup1p; shows colony morphology-related gene regulation by Ssn6p; transcription is positively regulated by Tbf1p 6265 RPS22A Predicted ribosomal protein; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 6253 RPS23A Putative ribosomal protein; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 5466 RPS24 Predicted ribosomal protein; hyphal downregulated; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage; transcription activated by Tbf1p 6663 RPS25B Predicted ribosomal protein; macrophage/pseudohyphal-induced after 16 h; downregulated upon phagocytosis by murine macrophage; transcription is positively regulated by Tbf1p; intron in 5'-UTR 1470 RPS26A Predicted ribosomal protein; regulated by Nrg1p, Tup1p; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage; intron in 5'-UTR 6286.2 RPS27 Putative ribosomal protein; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 413.1 RPS27A Predicted ribosomal protein S27; ORF Predicted by Annotation Working Group 7048.1 RPS28B Putative ribosomal protein S28B; ORF Predicted by Annotation Working Group 6312 RPS3 Putative ribosomal protein; Hog1p-induced; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 4375.1 RPS30 ORF Predicted by Annotation Working Group; putative 40S ribosomal protein S30; shows colony morphology-related gene regulation by Ssn6p 5341 RPS4A Predicted ribosomal protein; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage; transcription is positively regulated by Tbf1p 4336 RPS5 Predicted ribosomal protein; macrophage/pseudohyphal-induced after 16 h; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 6300 RPS620A Downregulation correlates with clinical development of fluconazole resistance; clade-associated gene expression; possibly spurious ORF (Annotation Working Group prediction); removed from Assembly 20 4660 RPS6A Predicted ribosomal protein; similar to ribosomal protein S10; localizes to cell surface of yeast-form cells, but not hyphal cells; genes encoding cytoplasmic ribosomal subunits are downregulated upon phagocytosis by murine macrophage 1700 RPS7A Predicted ribosomal protein; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 6873 RPS8A Putative ribosomal protein; similar to S. cerevisiae Rps8Bp; gene is induced by ciclopirox olamine treatment; genes encoding cytoplasmic ribosomal subunits are downregulated upon phagocytosis by murine macrophage; intron in 5'-UTR 838.1 RPS9B Predicted ribosomal protein; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage; possibly transcriptionally regulated upon hyphal formation 441 RPT1 Predicted ORF in Assemblies 19, 20 and 21; regulated by Gcn2p and Gcn4p 5440 RPT2 Predicted ORF in Assemblies 19, 20 and 21; oxidative stress-induced via Cap1p 482 RPT4 Predicted ORF in Assemblies 19, 20 and 21; regulated by Gcn2p and Gcn4p; protein level decreased in stationary phase cultures 3123 RPT5 Predicted ORF in Assemblies 19, 20 and 21; transcription is regulated by Nrg1p and Mig1p; regulated by Gcn2p and Gcn4p; protein level decreased in stationary phase cultures 3593 RPT6 Predicted ORF in Assemblies 19, 20 and 21; transcription is regulated by Mig1p; regulated by Gcn2p and Gcn4p 6792 RRD1 Predicted ORF in Assemblies 19, 20 and 21; caspofungin induced 718 RRN11 Putative RNA polymerase I subunit; transcription is upregulated in both intermediate and mature biofilms 1923 RRN3 Predicted ORF in Assemblies 19, 20 and 21; caspofungin induced, flucytosine repressed; downregulated in core stress response; decreased expression in response to prostaglandins 563 RRP15 Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins 58 RRP6 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine) 3630 RRP8 Predicted ORF in Assemblies 19, 20 and 21; induced upon biofilm formation 2830 RRP9 Predicted ORF in Assemblies 19, 20 and 21; mutation confers resistance to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine); physically interacts with TAP-tagged Nop1p 6014 RRS1 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine) 347 RSN1 Protein induced during the mating process 3628 RSP5 Predicted ORF in Assemblies 19, 20 and 21; induced during infection of murine kidney, compared to growth in vitro; has murine homolog 2614 RSR1 RAS-related protein; GTP/GDP cycling required for wild-type polar bud site selection, hyphal growth guidance; role in systemic virulence in mouse; geranylgeranylation predicted; suppresses S. cerevisiae cdc24-4 mutant heat sensitivity 24 RTA2 Putative floppase; required for sphingolipid long chain base release; mediates calcineurin-dependent resistance to azoles; stress-associated protein; Ca2+, calcineurin-regulated; ketoconazole, caspofungin induced; Plc1p-regulated 23 RTA3 Similar to S. cerevisiae Rta1p (role in 7-aminocholesterol resistance) and Rsb1p (flippase); putative membrane protein; putative drug-responsive regulatory site; induced by fluphenazine, estradiol, ketoconazole, caspofungin 6595 RTA4 Predicted ORF in Assemblies 19, 20 and 21; similar to S. cerevisiae Yor049cp, which is involved in fatty acid transport; transposon mutation affects filamentous growth; alkaline downregulated; caspofungin induced 7047 RTF1 Protein induced during the mating process 20 RTS1 Transcription is regulated upon yeast-hyphal switch 7124 RVS161 Protein required for endocytosis; contains a BAR domain, which is found in proteins involved in membrane curvature; null mutant exhibits defects in hyphal growth, virulence, cell wall integrity, and actin patch localization 6349 RVS162 Protein containing a BAR domain, which is found in proteins involved in membrane curvature; null mutant does not display the endocytic, hyphal growth, virulence, or cell wall defects exhibited by mutants in related genes RVS161 and RVS167 1220 RVS167 Protein involved in endocytosis; contains a BAR domain; null mutant exhibits defects in hyphal growth, virulence, cell wall integrity, and actin patch localization; cosediments with phosphorylated Myo5p 3568 RXT3 Predicted ORF in Assemblies 19, 20 and 21 1555 SAC3 Predicted ORF in Assemblies 19, 20 and 21 5544 SAC6 Transcription is regulated by Nrg1p and Mig1p; protein level decreased in stationary phase cultures 7115 SAC7 Protein described as a GTPase activating protein (GAP) for RHO1; downregulated upon adherence to polystyrene; macrophage/pseudohyphal-repressed; transcription is upregulated in RHE model of oral candidiasis and in clinical oral candidiasis 3911 SAH1 Protein described as S-adenosyl-L-homocysteine hydrolase; predicted enzyme of sulfur amino acid metabolism; antigenic in human; biofilm-, alkaline-, fluconazole-induced expression; Gcn4p-regulated; amino acid starvation (3-AT) repressed 5758 SAL6 Putative protein phosphatase of the Type 1 family (serine/threonine-specific), similar to S. cerevisiae Ppq1p; mutant shows virulence defect 657 SAM2 S-adenosylmethionine synthetase, localizes to surface of hyphal cells, but not yeast-form cells; possible biofilm-induced expression (reports differ); alkaline upregulated; Hog1p-induced; farnesol-downregulated 386 SAM4 Alkaline upregulated 5714 SAP1 Secreted aspartyl proteinase; acts in utilization of protein as nitrogen source; virulence role in mouse or guinea pig systemic infection, human or rat vaginal epithelium; regulated by growth phase, alpha-pheromone; produced by opaque cells 3839 SAP10 Secreted aspartyl proteinase; roles in adhesion, virulence (RHE model), cell surface integrity; distinct specificity from Sap9p; at cell membrane and wall; GPI-anchored; N-glycosylated; expression greater in low iron; Tbf1p-activated 3708 SAP2 Major secreted aspartyl proteinase; roles in use of protein as nitrogen source, virulence in mouse, rat, guinea pig, human vaginal epithelium; immunoprotective; allele-specific function; regulated by growth, albumin, drugs, white cell-type 6001 SAP3 Secreted aspartyl proteinase; acts in utilization of protein as nitrogen source; virulence role in mouse, guinea pig systemic infection or rat vagina; regulated by growth phase; produced by opaque phase cells; alpha-pheromone repressed 2082 SAP30 Aspartic-type endopeptidase involved in degradation of alpha pheromone; functional equivalent of S. cerevisiae Bar1p; specific to a-cells; transcription is induced in response to alpha pheromone 5716 SAP4 Secreted aspartyl proteinase; sap4 sap5 sap6 triple mutant has defects in systemic virulence (mouse, guinea pig), survival in macrophage, and protein utilization for nitrogen; expressed during mucosal and systemic infections, oral carriage 5585 SAP5 Secreted aspartyl proteinase; sap4 sap5 sap6 triple mutant has defects in virulence and utilization of protein as nitrogen source; expressed in mucosal & systemic infections, oral carriage; absent from less virulent species, C. dubliniensis 5542 SAP6 Secreted aspartyl proteinase; expressed upon hyphal growth, during oral carriage, mucosal, systemic infections; sap4 sap5 sap6 triple mutant has defects in systemic virulence, survival in macrophage, and protein utilization for nitrogen 756 SAP7 Member of the secreted aspartyl proteinase family; expression detected during human oral infection; regulated by Ssn6p; role in murine intravenous infection; induced during, but not required for, murine vaginal infection 242 SAP8 Secreted aspartyl proteinase; regulated by growth phase, temperature, and white-opaque switch; highly expressed in opaque cells; expressed upon deep epidermal invasion; greater expression during vaginal infection than oral infection 6928 SAP9 Secreted aspartyl proteinase; roles in adhesion, cell surface integrity; induced by antifungal drugs, stationary phase, or in white-phase cells; farnesol-downregulated in biofilm; autocatalytic processing; GPI-anchor; N-glycosylated 852 SAP98 Predicted ORF in Assemblies 19, 20 and 21; regulated by Gcn2p and Gcn4p; expressed in opaque MTLa/MTLa cells 853 SAP99 Putative secreted aspartyl protease; possible Kex2p substrate; transcriptionally regulated by iron; expression greater in low iron; repressed in response to alpha pheromone in SpiderM medium 3462 SAR1 Functional homolog of S. cerevisiae Sar1p, which is required for ER-to-Golgi protein transport; binds GTP; similar to small GTPase superfamily proteins; gene has intron 2717 SAS10 Predicted ORF in Assemblies 19, 20 and 21; mutation confers resistance to 5-fluorocytosine (5-FC); repressed upon high-level peroxide stress 2540 SAS3 Similar to silencing proteins; increased transcription is observed upon fluphenazine treatment 5749 SBA1 Similar to co-chaperones; transcriptionally regulated by iron; expression greater in high iron; farnesol-, heavy metal (cadmium) stress-induced; protein level decreased in stationary phase cultures 5854 SBP1 Similar to RNA binding proteins; downregulated upon adherence to polystyrene; protein detected by mass spec in exponential and stationary phase cultures 829 SCH9 Protein required for chlamydospore formation and for embedded hyphal growth, not essential for viability; similar to S. cerevisiae Sch9p, which is a protein kinase involved in growth control 5378 SCL1 Predicted ORF in Assemblies 19, 20 and 21; protein detected by mass spec in exponential and stationary phase cultures 17 SCP1 Predicted ORF in Assemblies 19, 20 and 21; constitutive expression independent of MTL or white-opaque status 3822 SCS7 Protein described as ceramide hydroxylase; transcription is regulated by Nrg1p; transcriptionally regulated by iron; expression greater in high iron; fluconazole-induced 1289 SCT1 Putative glycerol-3-phosphate O-acyltransferase; fungal-specific (no human or murine homolog) 5815 SCT2 Putative glycerol-3-phosphate acyltransferase; fungal-specific (no human or murine homolog) 3893 SCW11 Cell wall protein; transcription is decreased in mutant lacking ACE2; downregulated in core caspofungin response; transcriptionally regulated by iron; expression greater in high iron 2941 SCW4 Putative cell wall protein; exogenously expressed protein is a substrate for Kex2p processing in vitro; expression is regulated upon white-opaque switching; alkaline downregulated 6648 SDA1 Predicted ORF in Assemblies 19, 20 and 21; transcription is upregulated in both intermediate and mature biofilms 3899 SDC1 Predicted ORF in Assemblies 19, 20 and 21 440 SDH1 Protein described as mitochondrial succinate dehydrogenase; macrophage/pseudohyphal-induced; repressed by nitric oxide 2871 SDH12 Protein with similarity to S. cerevisiae SDH1, which is a flavoprotein subunit of succinate dehydrogenase; soluble protein in hyphae; macrophage-downregulated protein level; downregulated by Efg1p; repressed by nitric oxide 637 SDH2 Succinate dehydrogenase, Fe-S subunit; localizes to surface of yeast-form cells, but not hyphae; transcriptionally regulated by iron; expression greater in high iron; repressed by nitric oxide; induced during log phase (aerobic growth) 4022 SDH4 Succinate dehydrogenase, membrane subunit; transcriptionally regulated by iron; expression greater in high iron 820 SDS22 Predicted ORF in Assemblies 19, 20 and 21; macrophage/pseudohyphal-repressed 5118 SDS24 Protein described as similar to S. cerevisiae Ybr214wp; transcription regulated by Mig1p and Tup1p; fluconazole-induced 3409 SEC12 Protein described as a guanyl-nucleotide exchange factor; transcriptionally regulated by iron; expression greater in high iron 316 SEC13 Protein described as protein transport factor; antigenic during murine systemic infection; macrophage-downregulated protein abundance; protein level decreased in stationary phase cultures 941 SEC14 Essential protein; functional homolog of S. cerevisiae Sec14p, which is a Golgi phosphatidylinositol/phosphatidylcholine transfer protein that regulates choline-phosphate cytidyltransferase and thereby affects secretion; biofilm-regulated 1418 SEC15 Predicted exocyst subunit; ortholog of S. cerevisiae SEC15 4993 SEC18 Functional homolog of S. cerevisiae Sec18p, which acts in protein transport; conserved ATP binding site; not glycosylated 5526 SEC20 Essential protein; similar to S. cerevisiae Sec20p; depletion causes membrane accumulation and drug sensitivity; expression regulated by growth phase; O-mannosylation regulates proteolysis; does not complement S. cerevisiae sec20-1 mutant 1254 SEC23 Transcription is regulated upon yeast-hyphal switch 4732 SEC24 Possible role in ER to Golgi transport; induced upon yeast-hyphal switch 2911 SEC3 Predicted subunit of the exocyst complex, involved in exocytosis; required for hyphal growth after the first septin ring formation; interacts with septins Cdc3p, Cdc10p, and Cdc11p 4440 SEC34 Protein not essential for viability; similar to S. cerevisiae Cog3p, which is a component of the conserved oligomeric Golgi complex involved in intracellular protein trafficking 2571 SEC4 Small GTPase of Rab family; role in secretion, post-Golgi; possible C-terminal palmitoylation; downregulated on adherence to polystyrene; not regulated on white-opaque or yeast-hyphal switching; functional homolog of S. cerevisiae Sec4p 74 SEC5 Predicted exocyst component; ortholog of S. cerevisiae Sec5p; merged with orf19.75 in Assembly 21 6176 SEC61 Essential protein; expected to act in protein translocation from the endoplasmic reticulum: similar to S. cerevisiae Sec61p; chimeric mutant partially functionally complements S. cerevisiae sec61 defects; 10 transmembrane regions predicted 2557 SEC65 Functional homolog of S. cerevisiae Sec65p, which is a component of the protein-targeting Signal Recognition Particle (SRP); similar to mammalian Srp19; transcription is positively regulated by Tbf1p 5947 SEC7 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to Brefeldin A; caspofungin repressed 3753 SEF1 Putative transcription factor with zinc cluster DNA-binding motif; transcription is negatively regulated by Sfu1p and positively regulated by Tbf1p 1926 SEF2 Putative zinc cluster protein; expression is repressed by Sfu1p under high-iron conditions 5938 SEN1 Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins 4464 SEN15 Similar to delta subunit of tRNA splicing endonuclease; increased transcription is observed upon fluphenazine treatment 2735 SEN2 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to toxic ergosterol analog, and to amphotericin B; has intron in 5'-UTR 700 SEO1 Protein with similarity to permeases; transcription is negatively regulated by Sfu1p; flucytosine induced; transcriptionally activated by Mnl1p under weak acid stress 5484 SER1 Predicted ORF in Assemblies 19, 20 and 21; protein detected by mass spec in exponential and stationary phase cultures 5263 SER33 Predicted enzyme of amino acid biosynthesis; Gcn4p-regulated; upregulated in biofilm; protein detected by mass spec in exponential and stationary phase cultures; S. cerevisiae ortholog is Gcn4p regulated 269 SES1 Seryl-tRNA synthetase; charges the tRNA that recognizes the CUG codon, which typically specifies Leu, but specifies Ser in C. albicans; complements S. cerevisiae ses1 mutant viability; soluble protein in hyphae; macrophage-regulated 6009 SET1 Lysine histone methyltransferase; methylates K4 of histone H3; role in epithelial cell adhesion, agar-embedded filamentation, virulence in mouse; unique N-terminus is immunogenic in human 7221 SET3 Protein similar to S. cerevisiae Set3p, which is an NAD-dependent histone deacetylase; transposon mutation affects filamentous growth 3931 SFC1 Putative acyltransferase; alkaline upregulated; transcription is upregulated in both intermediate and mature biofilms 5163 SFI1 Predicted ORF in Assemblies 19, 20 and 21; essential for growth 454 SFL1 Protein involved in negative regulation of flocculation and filamentous growth; induced in core caspofungin response 3234.1 SFT1 ORF Predicted by Annotation Working Group; Plc1p-regulated 2342 SFT2 Transcription is regulated by Mig1p 4869 SFU1 Transcriptional regulator of iron-responsive genes; represses some iron utilization genes when iron is present; not required for wild-type hyphal growth; has two GATA1-like zinc fingers separated by Cys-rich iron-sensing region 1719 SGA1 Putative glucoamylase; fungal-specific (no human or murine homolog) 4363 SGD1 Predicted ORF in Assemblies 19, 20 and 21; downregulated during core stress response; transcription is increased in populations of cells exposed to fluconazole over multiple generations 1942 SGE1 Protein described as a multidrug resistance factor; transcriptionally regulated by iron; expression greater in low iron 3550 SGO1 Predicted ORF in Assemblies 19, 20 and 21; cell-cycle regulated periodic mRNA expression 5335 SGS1 Protein described as a DNA helicase; haploinsufficient for wild-type lifespan; upregulated upon treatment of biofilm with farnesol 4089 SGT1 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to radicicol 5823 SGT2 Protein abundance is affected by URA3 expression in the CAI-4 strain background; transcription is regulated by Mig1p 3669 SHA3 Protein similar to S. cerevisiae Sha3p, which is a serine/threonine kinase involved in glucose transport; transposon mutation affects filamentous growth; fluconazole-induced; ketoconazole-repressed; induced in response to alpha pheromone 729 SHE3 Protein similar to S. cerevisiae She3p; transposon mutation affects filamentous growth 2627 SHE3-3 Protein similar to S. cerevisiae She3p; transposon mutation affects filamentous growth; merged with orf19.729 in Assembly 20 5796 SHE9 Protein with similarity to S. cerevisiae She9p, which inhibits growth when overproduced; gene has possible growth-regulation element; fungal-specific (no human or murine homolog) 1342 SHM1 Mitochondrial serine hydroxymethyltransferase; complements the glycine auxotrophy of an S. cerevisiae shm1 null shm2 null gly1-1 triple mutant; protein detected by mass spec in exponential and stationary phase cultures 5750 SHM2 Cytoplasmic serine hydroxymethyltransferase; complements the glycine auxotrophy of an S. cerevisiae shm1 null shm2 null gly1-1 triple mutant; antigenic in human; soluble protein in hyphae; farnesol-upregulated in biofilm 4841 SHY1 Transcription is regulated by Nrg1p and Mig1p 7569 SIK1 Predicted ORF in Assemblies 19, 20 and 21; physically interacts with TAP-tagged Nop1p 5032 SIM1 Protein involved in cell wall maintenance, redundant with Sun41p; described as a DNA replication regulator; produced under vaginal conditions; macrophage-downregulated gene; transcription is negatively regulated by Rim101p, Cyr1p, Ras1p 6011 SIN3 Protein similar to S. cerevisiae Sin3p (transcriptional corepressor involved in histone deacetylase recruitment); has paired amphipathic helix PAH1 domain; interacts with ScOpi1p, not CaOpi1p; transposon mutation affects filamentous growth 1992 SIR2 Required for wild-type lifespan, asymmetric inheritance of oxidatively damaged proteins, rDNA silencing; regulates phenotypic switching in strain 3153A, not WO-1; partially functionally complements S. cerevisiae sir2 mutant mating defect 3861 SIS1 Predicted ORF in Assemblies 19, 20 and 21; macrophage/pseudohyphal-repressed; heavy metal (cadmium) stress-induced; heterozygous null mutant displays sensitivity to virgineone 2179 SIT1 Transporter of ferrichrome siderophores, but not ferrioxamine B; required for wild-type invasion of human epithelial cells in vitro, but not for wild-type systemic virulence in mouse; transcription regulated by iron, Sfu1p, Rfg1p, Tup1p 5200 SIT4 Serine/threonine protein phosphatase catalytic subunit; has a role in cell wall maintenance, hyphal growth, and virulence in a mouse systemic infection model 1850 SIW14 Putative protein phosphatase of the PTP family (tyrosine-specific), similar to S. cerevisiae Siw14p; mutant shows virulence defect 3345 SIZ1 Protein of unknown function; transcription is negatively regulated by Rim101p 4848 SKI3 Protein similar to S. cerevisiae Ski3p, which is required for repressing propagation of dsRNA viruses 5764 SKI8 Protein similar to S. cerevisiae Ski8p, which is required for repressing propagation of dsRNA viruses 7362 SKN1 Protein with predicted role in beta-1,6-glucan synthesis; probable N-glycosylated type II membrane protein; transcription and change in mRNA length induced by yeast-hyphal transition; transcription induced by Rim101p or caspofungin 348 SKN2 Protein with a potential role in beta-1,6 glucan biosynthesis; has similarity to Kre6p and Skn1p; predicted ORF in Assemblies 19, 20 and 21 971 SKN7 Putative homolog of S. cerevisiae Skn7p, which is predicted to be a response regulator protein in a phosphorelay signal transduction pathway 1032 SKO1 Putative transcription factor involved in cell wall damage response, similar to S. cerevisiae Sko1p; mutation causes caspofungin sensitivity; induced by osmotic stress via Hog1p; transcriptionally activated by Mnl1p under weak acid stress 4427 SKP1 Protein described as subunit D of kinetochore protein complex CBF3; regulated by Gcn4p; repressed in response to amino acid starvation (3-aminotriazole treatment) 1474 SLA1 Predicted ORF in Assemblies 19, 20 and 21; transcription is regulated by Nrg1p and Mig1p; fungal-specific (no human or murine homolog) 7201 SLA2 Actin binding protein, ortholog of S. cerevisiae Sla2p; required for alkaline pH-induced hyphal formation 250 SLC1 Protein repressed during the mating process 260 SLD1 Sphingolipid delta-8 desaturase, catalyzes desaturation at carbon-8 in the long-chain base moiety of ceramides during glucosylceramide synthesis 7631 SLD5 Predicted ORF in Assemblies 19, 20 and 21; cell-cycle regulated periodic mRNA expression 6826 SLF1 Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium; macrophage-induced gene 6763 SLK19 Alkaline-induced protein of plasma membrane; affects cell aggregation, cell wall; similar to S. cerevisiae Slk19p (a kinetochore protein with roles in mitosis, meiosis); required for wild-type virulence in mouse; macrophage-downregulated 3256 SLN1 Histidine kinase involved in a two-component signaling pathway that regulates cell wall biosynthesis 4079 SLP2 Predicted ORF in Assemblies 19, 20 and 21; similar to stomatin mechanoreception protein 6827 SLU7 Protein similar to S. cerevisiae Slu7p; transcription is induced in response to alpha pheromone in SpiderM medium 4367 SMC1 Protein described as similar to chromosomal ATPases; RNA abundance regulated by tyrosol and cell density; cell-cycle regulated periodic mRNA expression 3623 SMC2 Protein similar to S. cerevisiae Smc2p, which is a component of the condensin complex involved in mitotic chromosome condensation; induced under hydroxyurea treatment 262 SMC3 Protein likely to be essential for growth, based on an insertional mutagenesis strategy; similar to S. cerevisiae Smc3p, which is an ATPase involved in sister chromatid cohesion 964 SMC4 Predicted ORF in Assemblies 19, 20 and 21 2417 SMC5 Predicted ORF in Assemblies 19, 20 and 21; similar to S. cerevisiae Yol034wp, which is involved in DNA repair; transposon mutation affects filamentous growth 6568 SMC6 Predicted ORF in Assemblies 19, 20 and 21; cell-cycle regulated periodic mRNA expression; S. cerevisiae ortholog is not cell-cycle regulated 5486.1 SMD2 ORF Predicted by Annotation Working Group; flucytosine induced 4146 SMD3 Protein described as a core snRNP protein; induced upon adherence to polystyrene 2270 SMF12 Protein not essential for viability; similar to S. cerevisiae Smf1p, which is a manganese transporter; Gcn4p-regulated; alkaline upregulated; caspofungin repressed 2069 SMF3 Protein described as vacuolar iron transporter; alkaline upregulated; caspofungin repressed; transcriptionally activated by Mnl1p under weak acid stress 5058 SMI1 Decreased mRNA abundance observed in cyr1 homozygous null mutant hyphal cells; caspofungin repressed 6972 SMI1B Protein of unknown function; transcription is negatively regulated by Rim101p 1362 SMM1 Predicted ORF in Assemblies 19, 20 and 21; transcription is upregulated in both intermediate and mature biofilms 1462 SMP2 Transcription is regulated by Nrg1p 5792 SMP3 Mannosyltransferase of glycosylphosphatidylinositol (GPI) biosynthesis; catalyzes mannosylation of Man3-GPI precursor; essential for viability; 8-9 transmembrane regions predicted; has HQEXRF motif; functional homolog of S. cerevisiae Smp3p 670 SMT3 SUMO, small ubiquitin-like protein; Smt3p-conjugated proteins localize to septation site and mother side of bud neck; C. albicans septins appear not to be Smt3p-modified, in contrast to S. cerevisiae septins; similar to S. cerevisiae Smt3p 6135.1 SMX4 ORF Predicted by Annotation Working Group; flucytosine induced 1936 SNF1 Essential protein; functional homolog of S. cerevisiae Snf1p regulator of sugar metabolism; constitutively expressed; Thr208 phosphorylation may have regulatory role; up-regulation associated with azole resistance; has polyhistidine tract 1526 SNF2 Protein involved in transcriptional regulation; ortholog of S. cerevisiae Snf2p, which is the catalytic subunit of the SWI/SNF chromatin remodeling complex; interacts with Swi1p; SWI/SNF complex is essential for hyphal growth and virulence 5962 SNF3 Glucose and galactose sensor; fermentation, filamentation, virulence roles; in 20-member C. albicans glucose transporter family, extended C terminus; high-glucose repressed; induced in macrophage, repressed in biofilm 5768 SNF4 Protein similar to S. cerevisiae Snf4p transcriptional regulator; caspofungin repressed; transposon mutation affects filamentous growth 6040 SNF7 Protein involved in echinocandin, azole sensitivity; role in proteolytic activation of Rim101p; separable roles in RIM101 pathway and in transport from MVB to vacuole; similar to S. cerevisiae Snf7p component of ESCRT III complex 1333 SNG3 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to toxic ergosterol analog; shows colony morphology-related gene regulation by Ssn6p 1332 SNG4 Predicted ORF in Assemblies 19, 20 and 21; transcriptionally activated by Mnl1p under weak acid stress; shows Mob2p-dependent hyphal regulation 1927 SNM1 Protein described as similar to RNase MRP RNA binding protein; ciclopirox olamine induced 2948 SNO1 Protein of unknown function expressed during stationary phase; transcription is regulated by Tup1p, Efg1p 514 SNP3 Transcription is regulated by Mig1p 5759 SNQ2 Protein similar to S. cerevisiae Snq2p transporter; member of PDR subfamily of ABC family; transposon mutation affects filamentation; benomyl-induced transcription; detected at yeast-form cell plasma membrane by mass spec 5241 SNT1 Protein similar to S. cerevisiae Snt1p, which is an NAD-independent histone deacetylase; not essential for viability; transposon mutation affects filamentous growth 144 SNU114 Protein likely to be essential for growth, based on an insertional mutagenesis strategy; similar to S. cerevisiae Snu114p, which is an RNA helicase involved in pre-mRNA splicing 1990 SNX4 Protein induced during the mating process 2947 SNZ1 Detected in stationary phase cultures; soluble in hyphae; induced on yeast to hyphal switch, in response to 3-aminotriazole, or in azole-resistant strain overexpressing MDR1; regulated by Gcn4p, macrophage; no human/murine homolog 2770.1 SOD1 Cytosolic copper- and zinc-containing superoxide dismutase, involved in protection from oxidative stress and required for full virulence; alkaline upregulated by Rim101p; upregulated in the presence of human blood 3340 SOD2 Mitochondrial Mn-containing superoxide dismutase; protection against oxidative stress; active as homotetramer; N-terminal 34 amino acids removed upon mitochondrial import; H2O2-induced via Cap1p; alkaline downregulated, farnesol-induced 7111.1 SOD3 Cytosolic manganese-containing superoxide dismutase, involved in protection against oxidative stress; transcription downregulated by treatment with ciclopirox olamine, induced during stationary phase when SOD1 expression is repressed 2062 SOD4 Copper- and zinc-containing superoxide dismutase; role in response to host innate immune ROS; regulated on white-opaque switching; ciclopirox olamine induced; caspofungin repressed; member of family that includes SOD1, SOD4, SOD5, and SOD6 2060 SOD5 Copper- and zinc-containing superoxide dismutase; protective role against oxidative stress; induced by neutrophil contact, hyphal growth, caspofungin, osmotic or oxidative stress; member of a gene family including SOD1, SOD4, SOD5, and SOD6 2108 SOD6 Copper- and zinc-containing superoxide dismutase; expression regulated during planktonic growth; member of a gene family that includes SOD1, SOD4, SOD5, and SOD6; gene may contain an intron 5407 SOF1 Predicted ORF in Assemblies 19, 20 and 21; transcription is upregulated in both intermediate and mature biofilms 4448 SOG2 Leucine-rich-repeat domain protein of RAM cell wall integrity signaling network; role in cell separation, azole sensitivity; required for hyphal growth; lacks orthologs in higher eukaryotes 1429 SOH1 Predicted ORF in Assemblies 19, 20 and 21; cell-cycle regulated periodic mRNA expression 451 SOK1 Transcription is induced in response to alpha pheromone in SpiderM medium 6930 SOL1 Cell cycle regulator; partial functional homolog of S. cerevisiae Sic1p; protein degradation regulated by SCF(CDC4) pathway; CDK phosphorylation predicted; possibly spurious ORF (Annotation Working Group prediction) 704 SOL3 Predicted ORF in Assemblies 19, 20 and 21; macrophage-downregulated protein abundance; protein detected by mass spec in exponential and stationary phase cultures 2896 SOU1 Enzyme involved in utilization of L-sorbose; has sorbitol dehydrogenase, fructose reductase, and sorbose reductase activities; has NAD-binding site motif; transcriptional regulation affected by chromosome 5 copy number 2897 SOU2 Protein similar to Sou1p; not required for utilization of L-sorbose 6362 SPA2 Protein involved in cell polarity, Spitzenkorper formation; required for mouse virulence; localizes to hyphal tip; has cell-cycle regulated localization in yeast-form cells; functional domains conserved with S. cerevisiae Spa2p 76 SPB1 Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins 6298 SPB4 Predicted ORF in Assemblies 19, 20 and 21; flucytosine repressed 4181 SPC2 Transcription is induced upon filamentous growth 4930 SPC3 Essential protein; similar to S. cerevisiae Spc3p, a component of the signal peptidase complex required for signal peptidase activity; predicted integral ER membrane protein; complements spc3 and suppresses sec61 S. cerevisiae mutants 2600 SPC98 Predicted ORF in Assemblies 19, 20 and 21; periodic mRNA expression, peak at cell-cycle S/G2 phase 6032 SPE1 Ornithine decarboxylase; enzyme of polyamine biosynthesis; not essential for viability; functionally complements polyamine auxotrophy of S. cerevisiae spe1 mutant; upregulated in biofilm; downregulated upon adherence to polystyrene 568 SPE2 Predicted ORF in Assemblies 19, 20 and 21; possibly adherence-induced 2250 SPE3 Predicted ORF in Assemblies 19, 20 and 21 7081 SPL1 Protein similar to S. cerevisiae Spl1p, which is involved in tRNA splicing; member of pyridoxal-phosphate-dependent aminotransferase protein family; predicted to be essential 4151 SPO1 Protein similar to phospholipase B; fungal-specific (no human or murine homolog) 3589 SPO11 DNA endonuclease required for genetic recombination between homologous chromosomes during the parasexual cycle; produced in mitotically dividing cells; similar to S. cerevisiae Spo11p, which functions in recombination during meiosis 6222 SPO22 Predicted ORF in Assemblies 19, 20 and 21; similar to S. cerevisiae Spo22p 6885 SPO7 Protein similar to S. cerevisiae Spo7p; transcription is induced in response to alpha pheromone in SpiderM medium 4119 SPO72 Protein similar to S. cerevisiae sporulation protein; up-regulation associated with azole resistance 1311 SPO75 Similar to S. cerevisiae sporulation protein; fungal-specific (no human or murine homolog) 3018 SPP1 Predicted ORF in Assemblies 19, 20 and 21; induced by nitric oxide in yhb1 mutant; cell-cycle regulated periodic mRNA expression 2237 SPR1 Putative GPI-anchored protein; not essential for viability; similar to S. cerevisiae Spr1p, which is a sporulation-specific exo-1,3-beta-glucanase 4266 SPR28 Septin; similar to S. cerevisiae meiotic/sporulation septin; mutant has no obvious phenotype; two introns with noncanonical branch site and 5' splice site, respectively; splicing inhibited upon exposure to alpha-factor 1524 SPR3 Septin; mutant has no obvious phenotype 4157 SPS20 Predicted ORF in Assemblies 19, 20 and 21; protein detected by mass spec in stationary phase cultures 487 SPT14 Putative DNA-binding transcription factor; predicted role in regulation of biogenesis of the cell wall; upregulated in biofilm 422 SPT20 Protein described as a transcription factor; downregulated upon adherence to polystyrene; flucytosine repressed 1751 SPT23 Protein involved in regulation of unsaturated fatty acid biosynthesis; controls the expression of the Ole1p delta-9-fatty acid desaturase 7622 SPT3 Functional homolog of S. cerevisiae Spt3p; required for virulence in mouse systemic infection; homozygous null mutant is hyperfilamentous 1453 SPT5 Protein similar to S. cerevisiae Spt5p transcription elongation factor; transposon mutation affects filamentous growth 7136 SPT6 Protein similar to S. cerevisiae Spt6p transcription elongation factor; transposon mutation affects filamentous growth; transcription is upregulated in an RHE model of oral candidiasis and in clinical isolates from oral candidiasis 7572 SPT7 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to toxic ergosterol analog, and to amphotericin B 6190 SRB1 Essential GDP-mannose pyrophosphorylase; synthesizes GDP-mannose for protein glycosylation; functional homolog of S. cerevisiae Psa1p; at surface of yeast-form, not hyphal, cells; alkaline upregulated; induced on adherence to polystyrene 1451 SRB9 Protein with similarity to S. cerevisiae Srb9p transcription mediator; transposon mutation affects filamentous growth; suppresses S. cerevisiae diploid filamentous (flo8, ste7, ste12, tec1) or haploid invasive (flo8) mutant growth defects 1203 SRO77 Predicted ORF in Assemblies 19, 20 and 21; filament induced; fungal-specific (no human or murine homolog) 2859 SRP40 Predicted ORF in Assemblies 19, 20 and 21; macrophage/pseudohyphal-induced 3243 SRP54 Predicted ORF in Assemblies 19, 20 and 21; increased transcription in ssr1 homozygous null mutant 505 SRV2 Adenylate cyclase-associated protein that regulates adenylate cyclase activity; required for wild-type germ tube formation and for virulence in mouse systemic infection; mutant defects in filamentous growth are rescued by cAMP or dbcAMP 1065 SSA2 HSP70 family chaperone; antigenic; role in sensitivity to, import of beta-defensin peptides; ATPase domain binds histatin 5; at surface of hyphae, but not yeast-form cells; farnesol-downregulated in biofilm; caspofungin repressed 6367 SSB1 Putative heat shock protein; SSB subfamily of the HSP70 family; mRNA in yeast-form cells, germ tubes; at surface of yeast-form cells, but not hyphae; soluble in hyphae; antigenic in human, mouse systemic infection; macrophage, GCN-induced 1896 SSC1 Heat shock protein; at surface of yeast-form cells, but not hyphae; antigenic; soluble in hyphae; Gcn4p-regulated; induced upon amino acid starvation (3-aminotriazole) or upon adherence to polystyrene; macrophage-downregulated protein 3959 SSD1 Protein with role in resistance to host antimicrobial peptides; virulence role in murine infection; functional homolog of S. cerevisiae Ssd1p, which suppresses various mutant phenotypes; constitutively expressed and not cell-cycle regulated 5031 SSK1 Response regulator of two-component system; role in oxidative stress response, cell wall biosynthesis, virulence, hyphal growth on solid media; expressed in hyphae and yeast-form cells; putative peroxisomal targeting sequence (PTS1) 3775 SSK2 Protein described as similar to MAP kinase kinase kinases; transcription is downregulated in response to treatment with ciclopirox olamine 6798 SSN6 Functional homolog of S. cerevisiae Cyc8p/Ssn6p; Ssn6p and Tup1p regulate distinct sets of genes; hyphal growth regulator; overexpression or mutation causes avirulence in mouse IV infection; TPR motifs; repressed during hyphal growth 7355 SSN8 Protein not essential for viability; similar to S. cerevisiae Ssn8p, which is a component of RNA polymerase II holoenzyme 5145 SSP96 Predicted ORF in Assemblies 19, 20 and 21; has monooxygenase-like flavin-binding region; induced upon biofilm formation 7030 SSR1 Beta-glucan associated cell-wall protein with role in cell wall structure; S/T rich protein, GPI anchor; similar mRNA abundance in yeast-form and germ tube; detected at germ tube plasma membrane by mass spec; similar to S. cerevisiae Ssr1p 4222 SST2 Predicted regulator of G-protein signaling in mating pathway; homozygous null mutation causes alpha-factor hypersensitivity and mating defect (in an opaque MTLa/MTLa background); transcription induced by alpha factor 7313 SSU1 Protein similar to S. cerevisiae Ssu1p sulfite transport protein; transposon mutation affects filamentous growth; regulated by Gcn2p and Gcn4p; induced by nitric oxide 2402 SSU72 Predicted ORF in Assemblies 19, 20 and 21 4772 SSU81 Predicted adaptor protein involved in activation of MAP kinase-dependent signaling pathways; links response to oxidative stress to morphogenesis and cell wall biosynthesis; caspofungin repressed 814 SSY1 Amino acid sensor, required for wild-type hyphal growth on solid serum or Lees media, but not for hyphal growth under all conditions; similar to S. cerevisiae Ssy1p aa sensor and to aa permeases; 12 predicted membrane spanning regions 6422 SSY5 Protein similar to S. cerevisiae Ssy5p, which is a component of a complex that senses external amino acids 3812 SSZ1 Protein described as an HSP70 chaperone; protein level decreased in stationary phase cultures 203 STB3 Predicted ORF in Assemblies 19, 20 and 21; caspofungin induced; macrophage/pseudohyphal-repressed 6173 STD1 Protein described as transcription factor involved in control of glucose-regulated gene expression; repressed by Rgt1p 844 STE11 Predicted ORF in Assemblies 19, 20 and 21; similar to S. cerevisiae Ste11p 5851 STE13 Protein similar to S. cerevisiae Ste13p, which is a pheromone-processing dipeptidyl aminopeptidase; possible Kex2p substrate; transposon mutation affects filamentous growth; induced by low nitrogen, germ tube formation 6551.1 STE18 ORF Predicted by Annotation Working Group; similar to S. cerevisiae Ste18p; expressed in opaque or white MTLa/MTLa or MTLalpha/MTLalpha, but not MTLa/MTLalpha cells; MTLa1p, MTLalpha2p bind promoter region 696 STE2 Receptor for alpha factor mating pheromone, MFalpha; required for a-type cells to respond to alpha factor, for opaque a-form mating and white a-form response; possible Kex2p substrate; a-specific, alpha-factor induced, A1-Alpha2p repressed 5559 STE23 Protein similar to S. cerevisiae Ste23p, which is involved in maturation of pheromone; transposon mutation affects filamentous growth 2492 STE3 Protein similar to S. cerevisiae Ste3p, the receptor for a-factor mating pheromone; alpha mating-type-specific transcription 799 STE4 Beta subunit of heterotrimeric G protein of mating signal transduction pathway; required for mating; transcription is specific to cells homozygous at MTL and is induced by alpha pheromone; similar to S. cerevisiae Ste4p 1636 STE50 Protein with sterile alpha motif (SAM) and Ras-associated domain (RAD); similar to S. cerevisiae Rad50p, which is involved in signal transduction via interaction with and regulation of MAPKKK 2107.1 STF2 Protein involved in ATP biosynthesis; decreased expression in hyphae compared to yeast-form cells; downregulated by Efg1p; transcription is upregulated in clinical isolates from HIV+ patients with oral candidiasis 3192 STI1 Protein that interacts with Cdc37p and Crk1p in two-hybrid system; may be involved in Cdc37p chaperone activity; biofilm induced; soluble protein in hyphae; protein detected by mass spec in exponential and stationary phase cultures 4961 STP2 Transcription factor; activates transcription of genes encoding amino acid permeases; activated via amino-acid-induced proteolytic processing (Ssy1p and Csh3p dependent); also amino-acid-regulated 5917 STP3 Transcription factor; regulates SAP2, OPT1 expression and thereby protein catabolism for nitrogen source; activated via amino-acid-induced proteolytic processing; macrophage/pseudohyphal-repressed 909 STP4 Putative transcription factor with zinc finger DNA-binding motif; induced in core caspofungin response; shows colony morphology-related gene regulation by Ssn6p; induced by 17-beta-estradiol, ethynyl estradiol 1033 STR2 Protein not essential for viability; similar to S. cerevisiae Str2p, which is cystathionine gamma-synthase involved in sulfur metabolism 3059 SUA71 Predicted transcriptional regulator; downregulated during planktonic growth, whereas related SUA72 is induced; transcription is positively regulated by Tbf1p 3519 SUA72 Predicted transcriptional regulator; induced during planktonic growth, whereas related SUA71 is downregulated 5647 SUB2 Transcription is regulated by Mig1p 7319 SUC1 Putative transcriptional regulator with N-terminal zinc finger; regulates alpha-glucosidase in C. albicans and S. cerevisiae; in S. cerevisiae, complements suc2 mutant sucrose utilization defect and mal13 mutant maltase defect 1280 SUI1 Putative translation initiation factor; flucytosine induced; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 6213 SUI2 Putative translation initiation factor; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage; protein detected by mass spec in stationary phase cultures 7161 SUI3 Putative translation initiation factor; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 2738 SUL2 Protein described as a sulfate transporter; transcription is negatively regulated by Sfu1p; induced upon biofilm formation; amphotericin B induced 3642 SUN41 Putative cell wall glycosidase involved in biofilm formation; required for cell separation; hyphal induced; caspofungin repressed; Efg1p, Cph1p regulated; O-glycosylation, potential Kex2p substrate; 9 5' E-boxes; 5'-UTR intron 1378 SUP35 Translation factor eRF3; shows prion-like aggregation in some, not all, studies; partially complements S. cerevisiae sup35 mutant translation defect; species barrier with S. cerevisiae Sup35p prion; gene not regulated by yeast-hyphal switch 5818 SUR2 Protein described as similar to ceramide hydroxylase; predicted enzyme of sphingolipid biosynthesis; upregulated in biofilm; regulated by Tsa1p, Tsa1Bp under H2O2 stress conditions 3414 SUR7 Protein required for wild-type cell wall, plasma membrane, cytoskeletal organization, endocytosis; localizes to eisosome subdomains of plasma membrane; four transmembrane motifs; mutant shows ectopic, chitin-rich cell wall 4342 SUT1 Predicted ORF in Assemblies 19, 20 and 21 4519 SUV3 Protein required for chlamydospore formation, for embedded hyphal growth, and for wild-type respiratory growth; similar to S. cerevisiae Suv3p, which is an RNA helicase involved in mitochondrial RNA catabolism 6068 SVF1 Predicted ORF in Assemblies 19, 20 and 21; fluconazole-induced; regulated by Gcn4p; repressed in response to amino acid starvation (3-aminotriazole treatment); fungal-specific (no human or murine homolog) 7492 SWC4 Subunit of the NuA4 histone acetyltransferase complex 5388 SWD1 Predicted ORF in Assemblies 19, 20 and 21 2790 SWD2 Predicted ORF in Assemblies 19, 20 and 21 3457 SWD3 Predicted ORF in Assemblies 19, 20 and 21 4867 SWE1 Functional homolog of S. cerevisiae Swe1p; mutant cells are small, rounded, and sometimes binucleate; not required for filamentous growth; transcription is repressed in response to alpha pheromone in SpiderM medium 5657 SWI1 Protein involved in transcription regulation; ortholog of S. cerevisiae Swi1p, which is a subunit of the SWI/SNF chromatin remodeling complex; interacts with Snf2p; SWI/SNF complex is essential for hyphal growth and virulence 4545 SWI4 Predicted ORF in Assemblies 19, 20 and 21; periodic mRNA expression, peak at cell-cycle G1/S phase; predicted, conserved MBF binding sites upstream of G1/S-regulated genes 4725 SWI6 Predicted ORF in Assemblies 19, 20 and 21; periodic mRNA expression, peak at cell-cycle G1/S phase 768 SYG1 Protein not essential for viability; similar to S. cerevisiae Syg1p, which is a plasma membrane protein that may be involved in signal transduction 7128 SYS1 Predicted ORF in Assemblies 19, 20 and 21; transcription is regulated by Mig1p 2410 SYS3 Protein similar to S. cerevisiae Sys3p; putative role in endosome-Golgi vesicle docking; upregulated in biofilm; induced upon adherence to polystyrene 3188 TAC1 Transcriptional activator of drug-responsive genes including CDR1 and CDR2; has Zn(2)-Cys(6) binuclear cluster; binds DRE element; gene in zinc cluster region near MTL locus; resequencing indicates that TAC1 spans orf19.3188 and orf19.3189 798 TAF14 Putative DNA-binding transcription factor; putative TFIIF subunit; macrophage-induced protein 6193 TAF145 Protein likely to be essential for growth, based on an insertional mutagenesis strategy; similar to S. cerevisiae Taf145p, which is a component of RNA polymerase II transcription factor TFIID; flucytosine repressed 5174 TAF19 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to amphotericin B 1885 TAF4 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to toxic ergosterol analog 7454 TAF60 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to amphotericin B 4371 TAL1 Predicted ORF in Assemblies 19, 20 and 21; biofilm induced; oxidative stress-induced via Cap1p; induced by nitric oxide in yhb1 mutant; protein detected by mass spec in exponential and stationary phase cultures 6834.1 TAR1 Ortholog of S. cerevisiae Tar1p, encoded within the 25S rRNA gene on the opposite strand; transcription is positively regulated by Tbf1p 801 TBF1 Essential transcriptional activator that binds to a conserved sequence at ribosomal protein genes and the rDNA locus; acts with Cbf1p at a subset of promoters; biological role is analogous to that of S. cerevisiae Rap1p, not to S.c. Tbf1p 1837 TBP1 Transcription initiation factor; binds TATA box sequence, and binding does not require TFIIA; caspofungin repressed; functional homolog of S. cerevisiae and human TATA-binding proteins 2427 TCA5 Polyprotein of Tca5, a copia-like retrotransposon; has putative protease, integrase, reverse transcriptase, RNaseH parts mRNA detected in SC5314; similar to S. cerevisiae Ty5; mutation affects filamentous growth; removed from Assembly 20 6734 TCC1 Protein involved in regulation of filamentous growth and virulence; interacts with Tup1p; acts in transcriptional regulation of hypha-specific genes; contains 4 tetratricopeptide repeat (TPR) motifs; flucytosine repressed; Tbp1p-activated 761 TCO89 Protein described as a homolog of S. cerevisiae Tco89p, which is a component of the TOR C1 complex that is involved in the regulation of growth and cell wall integrity; heterozygous null mutant displays sensitivity to rapamycin 401 TCP1 Transcription is induced in response to alpha pheromone in SpiderM medium; protein detected by mass spec in stationary phase cultures 6814 TDH3 Glyceraldehyde-3-phosphate dehydrogenase; enzyme of glycolysis; binds fibronectin and laminin; at surface of yeast-form cells and hyphae; soluble in hyphae; antigenic during infection; NAD-linked; farnesol-downregulated 6985 TEA1 Putative transcription factor with zinc cluster DNA-binding motif; has similarity to S. cerevisiae Tea1p 5908 TEC1 TEA/ATTS transcription factor involved in regulation of hypha-specific genes; required for wild-type biofilm formation; regulates BCR1; directly transcriptionally regulated by Cph2p under some growth conditions; alkaline upregulated 1435 TEF1 Translation elongation factor 1-alpha, detected at surface of yeast-form and hyphal cells; binds human plasminogen; macrophage/pseudohyphal-induced; upregulated in an RHE model of oral candidiasis and in clinical oral candidiasis isolates 382 TEF2 Translation elongation factor 1-alpha; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 2652 TEF4 Putative translation elongation factor; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 3001 TEM1 Protein similar to S. cerevisiae Tem1p, which is a GTPase involved in termination of the M phase of the cell cycle; induced under Cdc5p depletion 3699 TEP1 Putative protein phosphatase of the PTP family (tyrosine-specific), similar to S. cerevisiae Tep1p 5089 TERT Telomerase reverse transcriptase; catalytic protein subunit of telomere synthesis; essential for telomerase activity; has telomerase-specific motif T and other conserved reverse transcriptase motifs 5217 TES1 Predicted ORF in Assemblies 19, 20 and 21 5215 TES15 Predicted ORF in Assemblies 19, 20 and 21 4851 TFA1 Protein with polyglutamate motifs and abundant Ser/Thr residues; described as a subunit of TFIIE, which is a basal transcription initiation factor of RNA Polymerase II 567 TFB3 Putative transcription factor with C3HC4 zinc finger DNA-binding motif; transcription is positively regulated by Tbf1p 274 TFC4 Predicted ORF in Assemblies 19, 20 and 21; transcriptionally activated by Mnl1p under weak acid stress 4585 TFG1 Protein similar to S. cerevisiae Tfg1p, which is part of transcription factor TFIIF; transposon mutation affects filamentous growth 1974 TFS1 Transcription is regulated upon yeast-hyphal switch; shows colony morphology-related gene regulation by Ssn6p 7324 THI13 Protein not essential for viability; similar to S. cerevisiae Thi13p, which is involved in synthesis of the thiamine precursor hydroxymethylpyrimidine; induced by nitric oxide in yhb1 mutant 889 THI20 Putative phosphomethylpyrimidine kinase; also described as a putative transcription factor with TENA DNA-binding motif; fungal-specific (no human or murine homolog) 5986 THI4 Protein repressed during the mating process; fungal-specific (no human or murine homolog); protein detected by mass spec in stationary phase cultures 277 THI6 Putative thiamin-phosphate pyrophosphorylase, hydroxyethylthiazole kinase; fungal-specific (no human or murine homolog) 923 THR1 Putative homoserine kinase; fungal-specific (no human or murine homolog); transcription is regulated by Tup1p; amphotericin B repressed; regulated by Gcn2p and Gcn4p 4233 THR4 Predicted ORF in Assemblies 19, 20 and 21; Gcn4p-regulated; protein detected by mass spec in exponential and stationary phase cultures 5685 THS1 Putative threonyl-tRNA synthetase; transcription regulated by Mig1p and Tup1p; downregulated upon phagocytosis by murine macrophages; protein detected by mass spec in stationary phase cultures 3324 TIF Protein similar to S. cerevisiae translation initiation factor; upregulated in highly virulent strain compared to less virulent strain; antigenic in human; flucytosine induced; translation-related genes are downregulated upon phagocytosis 5351 TIF11 Predicted translation initiation factor eIF1a; possibly transcriptionally regulated upon hyphal formation; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 3423 TIF3 Putative translation initiation factor; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 2967 TIF34 Putative translation initiation factor; mutation confers hypersensitivity to roridin A and verrucarin A; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 7236 TIF35 Putative translation initiation factor; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 3599 TIF4631 Putative translation initiation factor eIF4G; overexpression causes hyperfilamentation; hyphal- and macrophage-induced; genes encoding some translation factors are downregulated upon phagocytosis by murine macrophage 4261 TIF5 Putative translation initiation factor; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 6696 TIM9 Predicted ORF in Assemblies 19, 20 and 21; transcription is upregulated in both intermediate and mature biofilms 3951 TIP1 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to toxic ergosterol analog 6729 TIP120 Protein similar to human and rat TBP-binding transcription regulatory protein; not essential for viability 4003 TIP20 Protein interacting with Sec20p, possibly involved in retrograde transport between the Golgi and the endoplasmic reticulum; similar to S. cerevisiae Tip20p 5112 TKL1 Putative transketolase; localizes to surface of yeast-form cells, but not hyphae; soluble protein in hyphae; transcription is regulated by Nrg1p, Mig1p, and Tup1p; antigenic in human or murine infection 1538 TLG2 Predicted ORF in Assemblies 19, 20 and 21; macrophage/pseudohyphal-repressed 7544 TLO1 Member of a family of telomere-proximal genes of unknown function; hyphal-induced expression 3074 TLO10 Member of a family of telomere-proximal genes of unknown function 5700 TLO11 Member of a family of telomere-proximal genes of unknown function; may be spliced in vivo 6337 TLO13 Member of a family of telomere-proximal genes of unknown function; may be spliced in vivo; overlaps orf19.6337.1, which is a region annotated as blocked reading frame 7127 TLO16 Member of a family of telomere-proximal genes of unknown function; may be spliced in vivo 2661 TLO34 Non-telomeric member of a family of telomere-proximal genes of unknown function; predicted N-terminus is extended, relative to that of other family members 7276.1 TLO4 Member of a family of telomere-proximal genes of unknown function; transcription is upregulated in an RHE model of oral candidiasis 1925 TLO5 Member of a family of telomere-proximal genes of unknown function; may be spliced in vivo 5467 TLO7 Member of a family of telomere-proximal genes of unknown function; may be spliced in vivo 6191 TLO8 Member of a family of telomere-proximal genes of unknown function; may be spliced in vivo 362 TLO9 Member of a family of telomere-proximal genes of unknown function 4335 TNA1 Putative nicotinic acid transporter; fungal-specific (no human or murine homolog); detected at germ tube plasma membrane by mass spectrometry; transcriptionally induced upon phagocytosis by macrophage 4625 TOA2 Protein abundance is decreased in the CAI-4 strain background compared to the SC5314 strain background, and abundance is not affected by reintegration of URA3 in CAI-4; flucytosine induced 4175 TOK1 Outwardly rectifying, noisily gated potassium channel; modulates sensitivity to human salivary histatin (Hst5); very similar to S. cerevisiae Tok1p 5776 TOM1 Predicted ORF in Assemblies 19, 20 and 21; transcription is regulated by Nrg1p and Mig1p 3696 TOM22 Predicted ORF in Assemblies 19, 20 and 21; shows colony morphology-related gene regulation by Ssn6p 3700 TOM70 Protein described as mitochondrial import receptor 6531.1 TOM71 ORF Predicted by Annotation Working Group; flucytosine induced 96 TOP1 DNA topoisomerase I; required for wild-type growth and for wild-type mouse virulence; sensitive to camptothecin; induced upon adherence to polystyrene 2873 TOP2 DNA topoisomerase II; catalyzes ATP-dependent DNA relaxation and decatenation in vitro; Y842 predicted to be catalytic; functional homolog of S. cerevisiae Top2p; sensitive to amsacrine or doxorubicin; farnesol-upregulated in biofilm 2290 TOR1 Protein similar to TOR family phosphatidylinositol kinases; mutation confers resistance to rapamycin; involved in regulation of ribosome biogenesis, starvation response, and adhesion 1690 TOS1 Protein described as similar to alpha agglutinin anchor subunit; exogenously expressed protein is a substrate for Kex2p processing in vitro; fluconazole-induced; transcription is induced in response to alpha pheromone in SpiderM medium 6745 TPI1 Triose-phosphate isomerase; glycolysis/gluconeogenesis; antigenic in mouse or human; mutation affects filamentous growth; biofilm-induced; macrophage-downregulated protein; detected by mass spec in exponential and stationary phase culture 4892 TPK1 Catalytic subunit of cAMP-dependent protein kinase (PKA), isoform of Tpk2p; involved in control of morphogenesis and stress response; wild-type nuclear localization requires Bcy1p; produced during stationary but not exponential growth 2277 TPK2 Catalytic subunit of cAMP-dependent protein kinase (PKA), isoform of Tpk1p; required for wild-type epithelial cell damage and engulfment and oral (not systemic) virulence in mouse; involved in control of morphogenesis and stress response 6414.3 TPM2 Protein described as tropomyosin isoform 2; regulated by Gcn4p; repressed in response to amino acid starvation (3-aminotriazole treatment); macrophage-induced protein; protein level decreased in stationary phase cultures 7148 TPO2 Putative polyamine transport protein; fungal-specific (no human or murine homolog) 4737 TPO3 Possible role in polyamine transport; MFS-MDR family; transcription induced by Sfu1p, regulated upon white-opaque switching; decreased expression in hyphae compared to yeast-form cells; regulated by Nrg1p; fungal-specific 473 TPO4 Putative sperimidine transporter; fungal-specific (no human or murine homolog) 151 TPO5 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to toxic ergosterol analog; hyphal induced; macrophage induced 6640 TPS1 Trehalose-6-phosphate synthase; role in hyphal growth and virulence in mouse systemic infection; upregulated in presence of human neutrophils; macrophage/pseudohyphal-repressed after 16h; detected by mass spec in stationary phase cultures 3038 TPS2 Trehalose-6-phosphate (Tre6P) phosphatase; mutation causes heat sensitivity, Tre6P accumulation, and decreased mouse virulence; possible drug target; two conserved phospohydrolase motifs; no human or murine homolog 5348 TPS3 Protein described as regulatory subunit of trehalose-phosphate synthase; regulated by Efg1p; biofilm-repressed expression; regulated by Tsa1p, Tsa1Bp under H2O2 stress conditions 5432 TPT1 tRNA 2'-phosphotransferase; enzyme of tRNA splicing; functionally complements viability of S. cerevisiae tpt1 null mutant 139 TRA1 Subunit of the NuA4 histone acetyltransferase complex 600 TRK1 Potassium transporter; mediates K+ and Cl- influx; role in sensitivity to cationic antimicrobial peptides, not via direct peptide uptake, but possibly related to membrane permeability; fungal-specific (no human or murine homolog) 3265 TRM1 Protein described as an N2,N2-dimethylguanine tRNA methyltransferase; induced upon adherence to polystyrene 3327 TRM2 Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins 6378 TRM9 Protein repressed during the mating process 6096 TRP1 Phosphoribosylanthranilate isomerase; enzyme of tryptophan biosynthesis; expected to be unifunctional, unlike trifunctional enzyme of some other fungi; complements E. coli trpC or S. cerevisiae trp1 mutant; CCT1 and TRP1 genes overlap 2546 TRP2 Predicted ORF in Assemblies 19, 20 and 21; regulated by Gcn2p and Gcn4p 5243 TRP3 Predicted ORF in Assemblies 19, 20 and 21; regulated by Gcn2p and Gcn4p 3099 TRP4 Predicted enzyme of amino acid biosynthesis; upregulated in biofilm; regulated by Gcn2p and Gcn4p; S. cerevisiae ortholog is Gcn4p regulated 4718 TRP5 Predicted tryptophan synthase; Gcn4p-regulated; upregulated in biofilm; identified in detergent-resistant membrane fraction (possible lipid raft component); predicted N-terminal acetylation; S. cerevisiae ortholog is Gcn4p regulated 424 TRP99 Protein described as thioredoxin peroxidase/alkyl hydroperoxide reductase; transcriptionally regulated by iron; expression greater in low iron; regulated by Gcn4p; induced in response to amino acid starvation (3-aminotriazole treatment) 4290 TRR1 Putative thioredoxin reductase; upregulated in presence of human neutrophils; regulated by Tsa1p, Tsa1Bp; induced by nitric oxide; peroxide-induced; oxidative stress-induced via Cap1p; fungal-specific (no human/murine homolog) 6496 TRS33 Predicted ORF in Assemblies 19, 20 and 21; constitutive expression independent of MTL or white-opaque status 7611 TRX1 Similar to thioredoxin; biofilm, benomyl, flucytosine, peroxide induced; amphotericin B, caspofungin repressed; upregulated in the presence of human neutrophils; macrophage-downregulated gene 1976 TRX2 Predicted ORF in Assemblies 19, 20 and 21 7417 TSA1 Protein of TSA/alkyl hydroperoxide peroxidase C (AhPC) family; similar to thiol-dependent peroxidases of oxidative stress signaling; antigenic; hyphal surface, nucleus; yeast-form nucleus, cytoplasm; biofilm, phagocytosis, peroxide induced 7398.1 TSA1B Putative peroxidase; orf19.7398.1 is contig-truncated fragment of gene identical to TSA1; Tsa1p and Tsa1Bp role under oxidative/reductive stress, hyphal cell wall formation; in hyphal nucleus, cell wall; yeast-form nucleus, cytoplasm 728 TSC11 Protein similar to S. cerevisiae Tsc11p which is involved in sphingolipid biosynthesis; transposon mutation affects filamentous growth 1798 TSC2 Putative GTPase-activating protein involved in control of filamentous growth; not essential for viability; similar to mammalian tuberin 2135 TSM1 Putative protein of unknown function, transcription is upregulated in clinical isolates from HIV+ patients with oral candidiasis; transcription is regulated by Nrg1p; predicted ORF in Assemblies 19, 20 and 21 6417 TSR1 Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins 2998 TSR2 Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins 6059 TTR1 Putative glutaredoxin; described as a glutathione reductase; upregulated in the presence of human neutrophils, and upon benomyl treatment; alkaline downregulated; regulated by Gcn2p and Gcn4p; required for virulence in mouse model 7308 TUB1 Alpha-tubulin; gene has intron; complements cold-sensitivity of S. cerevisiae tub1 mutant; C. albicans has single alpha-tubulin gene, whereas S. cerevisiae has two (TUB1, TUB3); farnesol-upregulated in biofilm 6034 TUB2 Beta-tubulin; functional homolog of ScTub2p; hyphal-induced; fluconazole-induced; gene has two introns; overproduction causes inviability in S. cerevisiae; slow growth, increased white-to opaque switching in ectopic expression strains 1238 TUB4 Putative gamma-tubulin; induced upon adherence to polystyrene; transcription is regulated by Nrg1p and Mig1p; periodic mRNA expression, peak at cell-cycle S/G2 phase 6047 TUF1 Putative translation elongation factor; macrophage/pseudohyphal-induced; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 6109 TUP1 Transcriptional corepressor; represses filamentous growth, regulates phase switching, roles in germ tube induction, farnesol response; has C-terminal WD40 repeats; farnesol upregulated in biofilm; in repression pathways with Nrg1p, Rfg1p 4941 TYE7 Putative bHLH (basic region, helix-loop-helix) transcription factor; hyphally regulated via Cph1p, Cyr1p; flucytosine, Hog1p induced; amphotericin B, caspofungin repressed; downregulated in azole-resistant strain overexpressing MDR1 4605 TYR1 Putative prepephenate dehydrogenase; enzyme of tyrosine biosynthesis; fungal-specific (no human or murine homolog) 2694 TYS1 Putative tRNA-Tyr synthetase; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage; protein detected by mass spec in stationary phase cultures 4265 UAP1 UDP-N-acetylglucosamine pyrophosphorylase, catalyzes biosynthesis of UDP-N-acetylglucosamine from UTP and N-acetylglucosamine 1-phosphate; functional homolog of S. cerevisiae Qri1p; alkaline upregulated 7438 UBA1 Protein similar to S. cerevisiae Uba1p, which is a ubiquitin-activating enzyme that is essential for growth; protein level decreased in stationary phase cultures 2324 UBA4 Predicted ORF in Assemblies 19, 20 and 21; increased expression in response to prostaglandins; clade-associated gene expression 5337 UBC15 Predicted ORF in Assemblies 19, 20 and 21 7571 UBC4 Protein similar to S. cerevisiae ubiquitin conjugating enzyme Ubc4p 4540 UBC8 Protein similar to S. cerevisiae Ubc8p; transcription is induced in response to alpha pheromone in SpiderM medium 3087 UBI3 Fusion of ubiquitin with the S34 protein of the small ribosomal subunit; mRNA decreases upon heat shock, appears to be degraded; functional homolog of S. cerevisiae RPS31 6771 UBI4 Ubiquitin precursor (polyubiquitin), contains three tandem repeats of the ubiquitin peptide that are processed to individual units; transcription is induced by stress; mRNA found in yeast-form and mycelial cells at similar abundance 7367 UBP1 Protein described as ubiquitin carboxyl-1-terminal hydrolase 6063 UBP6 Predicted ORF in Assemblies 19, 20 and 21; oxidative stress-induced via Cap1p 2695 UBR1 Protein similar to S. cerevisiae Ubr1p ubiquitin-protein ligase; transposon mutation affects filamentous growth 1354 UCF1 Transcriptionally regulated by iron or by yeast-hyphal switch; expression greater in high iron, decreased upon yeast-hyphal switch; downregulation correlates with clinical development of fluconazole resistance; Ras1p-regulated 4646 UEC1 Protein required for damage to oral epithelial cells and for normal hyphal growth and stress resistance; transcription induced on contact with vascular endothelial cells; not highly conserved 7141 UFE1 Protein interacting with Sec20p, possibly involved in retrograde transport between the Golgi and the endoplasmic reticulum; functional homolog of S. cerevisiae Ufe1p, which is an ER t-SNARE that mediates the retrograde traffic 802 UGA1 Protein described as GABA transaminase; transcription regulated by Mig1p and Tup1p; protein detected by mass spec in stationary phase cultures 854 UGA11 Predicted ORF in Assemblies 19, 20 and 21; macrophage-induced gene; overlaps orf19.854.1, which is a region annotated as a blocked reading frame 4543 UGA2 Protein not essential for viability; similar to S. cerevisiae Uga2p, which is succinate semialdehyde dehydrogenase with a role in glutamate catabolism; transcription regulated by Mig1p, Tup1p, Gcn4p 2479 UGA4 Putative gamma-aminobutyric acid/polyamine permease; nitrogen catabolite repressed gene, induced in absence of preferred N sources; transcriptionally induced upon phagocytosis by macrophage; gene regulation by nitrogen source requires Gat1p 5820 UGA6 Predicted ORF in Assemblies 19, 20 and 21; decreased transcription is observed upon benomyl treatment or in an azole-resistant strain that overexpresses MDR1 1738 UGP1 Protein similar to UTP-glucose-1-phosphaturidyl transferase; localizes to cell surface of yeast-form cells, but not hyphal cells; Hog1p-downregulated; protein detected by mass spec in stationary phase cultures 2616 UGT51C1 UDP-glucose:sterol glucosyltransferase; enzyme of sterol glucoside (membrane-bound lipid) biosynthesis; has UDP-sugar binding domain; activity is UDP-glucose-specific in vitro; enzyme does not use UDP-mannose; Mig1p-regulated gene 353 ULP1 Putative SUMO deconjugation enzyme that cleaves the small ubiquitin-like modifier (SUMO) off proteins 4353 ULP2 Putative SUMO deconjugation enzyme that removes the small ubiquitin-like modifier (SUMO) from proteins 5441 ULP3 Putative SUMO deconjugation enzyme that removes the small ubiquitin-like modifier (SUMO) from proteins 1822 UME6 Transcription factor; required for wild-type hyphal extension, virulence; zinc cluster DNA-binding motif; similar to S. cerevisiae Ume6p, which is a meiotic regulator; alkaline upregulated; filament induced; regulated by Nrg1p, Tup1p, RFG1p 391 UPC2 Transcriptional regulator of ergosterol biosynthetic genes and sterol uptake; binds ERG2 promoter; has Zn(2)-Cys(6) binuclear cluster; induced upon ergosterol depletion, by azoles, anaerobicity; macrophage/pseudohyphal-repressed 4836 URA1 Dihydroorotate dehydrogenase (DHODH); enzyme of de novo pyrimidine biosynthesis; putative bipartite mitochondrial targeting motif, membrane spanning region; transcription is regulated upon yeast-hyphal switch, or by Nrg1p, Mig1p, Tup1p 2360 URA2 Predicted ORF in Assemblies 19, 20 and 21; flucytosine induced; macrophage/pseudohyphal-induced; intron in 5'-UTR 1716 URA3 Orotidine-5'-phosphate decarboxylase, enzyme of pyrimidine biosynthesis; gene used as a molecular genetic marker, but decreased expression when integrated at ectopic chromosomal locations can cause defects in hyphal growth and virulence 1977 URA4 Predicted ORF in Assemblies 19, 20 and 21; protein detected by mass spec in exponential and stationary phase cultures 2555 URA5 Protein abundance is affected by URA3 expression in the CAI-4 strain background; flucytosine induced; protein level decreased in stationary phase cultures 3941 URA7 Predicted ORF in Assemblies 19, 20 and 21; flucytosine induced; protein detected by mass spec in exponential and stationary phase cultures 155 URE2 Functional homolog of S. cerevisiae Ure2p, which is a regulator of nitrogen utilization, and which also has a prion form called [URE3] 5864 URK1 Protein described as similar to uridine kinase; transcription is downregulated in response to treatment with ciclopirox olamine 306 USO5 Protein of unknown function; transcription is induced upon filamentous growth and in response to alpha pheromone in SpiderM medium 6967 USO6 Transcription is induced upon filamentous growth 4268 UTP13 Predicted ORF in Assemblies 19, 20 and 21; downregulated in core stress response; physically interacts with TAP-tagged Nop1p 3609 UTP15 Predicted ORF in Assemblies 19, 20 and 21; mutation confers resistance to 5-fluorocytosine (5-FC); physically interacts with TAP-tagged Nop1p 7154 UTP18 Predicted ORF in Assemblies 19, 20 and 21; downregulated during core stress response; physically interacts with TAP-tagged Nop1p 3159 UTP20 Protein likely to be essential for growth; similar to S. cerevisiae Utp20p, which is a putative snoRNA-binding protein; downregulated in core stress response; mutation confers resistance to 5-fluorocytosine (5-FC) and parnafungin 1566 UTP21 Predicted ORF in Assemblies 19, 20 and 21; physically interacts with TAP-tagged Nop1p 1569 UTP22 Predicted ORF in Assemblies 19, 20 and 21; decreased expression observed in an ssr1 homozygous null mutant; decreased expression in response to prostaglandins; heterozygous null mutant exhibits resistance to parnafungin 1633 UTP4 Predicted ORF in Assemblies 19, 20 and 21; physically interacts with TAP-tagged Nop1p 7599 UTP5 Predicted ORF in Assemblies 19, 20 and 21; mutation confers resistance to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine); physically interacts with TAP-tagged Nop1p 5436 UTP8 Essential protein involved in tRNA export from the nucleus and ribosomal small subunit biogenesis; physically interacts with TAP-tagged Nop1p 6710 UTP9 Predicted ORF in Assemblies 19, 20 and 21; decreased expression observed in an ssr1 homozygous null mutant; decreased expression in response to prostaglandins; physically interacts with TAP-tagged Nop1p 1671 UTR2 Putative glycosidase; cell wall; role in adhesion; required for hyphal growth on Spider (not serum) medium; chitin-binding, glycosyl hydrolase, GPI anchor domains; induced during cell wall regeneration; mRNA detected in yeast-form cells 1409 VAC7 Protein not essential for viability; similar to S. cerevisiae Fab1p, which is an enzyme regulator involved in phospholipid metabolism 745 VAC8 Protein involved in vacuolar inheritance; required for hyphal growth; contains armadillo repeats 5875 VAM3 Predicted ORF in Assemblies 19, 20 and 21 6738 VAN1 Member of Mnn9p family; similar to S. cerevisiae Van1p; fungal-specific (no human or murine homolog) 1295 VAS1 Putative tRNA-Val synthetase; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 405 VCX1 Putative H+/Ca2+ antiporter; fungal-specific (no human or murine homolog) 3077 VID21 Subunit of the NuA4 histone acetyltransferase complex; soluble protein in hyphae 6324 VID27 Protein similar to S. cerevisiae Vid27p; transposon mutation affects filamentous growth; mutation confers hypersensitivity to toxic ergosterol analog; fungal-specific (no human or murine homolog) 6538 VMA11 Predicted ortholog of S. cerevisiae Tfp3p, which is the c' subunit of the V0 subcomplex of the vacuolar ATPase; required for hemoglobin-iron utilization 6634 VMA2 Predicted ORF in Assemblies 19, 20 and 21; amphotericin B repressed, caspofungin repressed; protein detected by mass spec in exponential and stationary phase cultures 2598 VMA4 Transcription is regulated by Mig1p; caspofungin repressed; protein level decreased in stationary phase cultures 806 VMA7 Putative subunit of the V-ATPase complex, which is involved in control of vacuolar pH; highly similar to S. cerevisiae Vma7p; interacts with phosphatidylinositol 3-kinase Vps34p 2895 VMA8 Protein similar to the S. cerevisiae Vma8p subunit of vacuolar H+-ATPase; transcription is regulated by Nrg1p and Mig1p; transcription is increased in populations of cells exposed to fluconazole over multiple generations 6863 VPH1 Predicted ORF in Assemblies 19, 20 and 21; transcription is regulated by Nrg1p, Mig1p, and Tup1p 1949 VPS1 Protein described as a dynamin-family GTPase-related protein; induced upon adherence to polystyrene; regulated by Gcn2p and Gcn4p 4403 VPS11 Protein involved in protein trafficking; putative role in vesicle-target membrane fusion; mutant lacks vacuole; role in hyphal growth, possibly via vacuole expansion into hypha; role in killing of and survival within macrophage 4416 VPS13 Predicted ORF in Assemblies 19, 20 and 21; gene used for multilocus sequence typing 6848 VPS16 Protein similar to S. cerevisiae Vps16p, which is involved in protein-vacuolar targeting; likely to be essential for growth, based on insertional mutagenesis; downregulated in biofilm or in azole-resistant strain that overexpresses MDR1 3344 VPS17 Predicted ORF in Assemblies 19, 20 and 21; fungal-specific (no human or murine homolog) 945 VPS2 Protein similar to S. cerevisiae Did4p/Vps2p, which is a member of the ESCRT III complex 589 VPS21 Late endosomal Rab small monomeric GTPase involved in transport of endocytosed proteins to the vacuole; involved in filamentous growth and virulence 2343 VPS23 Protein involved in proteolytic activation of Rim101p, which regulates pH response; similar to S. cerevisiae Stp22p/Vps23p, which is a member of the ESCRT I protein sorting complex 2031 VPS24 Protein similar to S. cerevisiae Vps24p, which is a member of the ESCRT III protein sorting complex; downregulated upon adherence to polystyrene 212 VPS28 Protein involved in proteolytic activation of Rim101p, which regulates pH response; role in echinocandin, azole sensitivity; similar to S. cerevisiae Vps28p, which is a subunit of the ESCRT I protein sorting complex 5214 VPS33 Predicted ORF in Assemblies 19, 20 and 21; similar to S. cerevisiae Vps33p, which is the product of a class C vacuolar protein sorting (vps) gene 6243 VPS34 Autophosphorylated phosphatidylinositol 3-kinase, class III, required for wild-type vesicle transport, hyphal growth, adherence to fibroblasts, and virulence in mouse systemic infection; low abundance mRNA, growth-regulated 6875 VPS35 Putative role in vacuolar sorting; downregulated in biofilm; induced upon adherence to polystyrene 795 VPS36 Protein involved in proteolytic activation of Rim101p, which regulates pH response; role in uptake of Histatin-5 into vacuole; similar to S. cerevisiae Vps36p, which is a member of the ESCRT II protein sorting complex 4339 VPS4 Protein involved in transport from multivesicular body (MVB) to the vacuole; mutation causes decreased SAP secretion and decreased virulence in murine intravenous infection; regulated by Gcn2p and Gcn4p 4858 VPS41 Protein similar to S. cerevisiae Vps41p, which is involved in vacuole organization and biogenesis; transposon mutation affects filamentous growth; regulated by Gcn4p; induced in response to amino acid starvation (3-aminotriazole treatment) 5568 VPS51 Protein with a role in vacuolar function; null mutant has defect in damaging oral epithelial and vascular endothelial cells; required for normal hyphal growth and stress resistance; induced in presence of host oral or vascular cells 5387 VPS8 Protein described as a vacuolar sorting protein; downregulated upon adherence to polystyrene 1232 VRG4 GDP-mannose transporter; essential; required for glycosylation, hyphal growth; functional homolog of S. cerevisiae Vrg4p, which imports GDP-mannose from cytoplasm to Golgi for protein and lipid mannosylation; no mammalian homolog 2190 VRP1 Protein described as verprolin; downregulated upon adherence to polystyrene 4381 VTC3 Putative polyphosphate synthetase; downregulated in core caspofungin response; Hog1p-induced; transcription is opaque-specific; fungal-specific (no human or murine homolog) 3363 VTC4 Protein described as polyphosphate synthetase; decreased expression in hyphae compared to yeast-form cells; fungal-specific (no human or murine homolog); virulence-group-correlated expression 6598 WAL1 Protein required for hyphal growth and for wild-type cell morphology, polarized budding, endocytosis, vacuole morphology; similar to Wiskott-Aldrich syndrome protein; localizes to cortical actin patches and hyphal tips 1035 WAR1 Predicted zinc cluster protein involved in resistance to weak organic acids; has similarity to S. cerevisiae War1p, which is a transcription factor involved in the regulation of weak acid stress response genes 3548.1 WH11 Cytoplasmic protein expressed specifically in white phase yeast-form cells; expression in opaque cells increases virulence and frequency of opaque-to-white switching; null mutant shows wild-type switching; similar to S. cerevisiae Hsp12p 6494 WHI3 Predicted ORF in Assemblies 19, 20 and 21; induced during infection of murine kidney, compared to growth in vitro; has murine homolog 4884 WOR1 Transcriptional regulator (master switch) of white-opaque phenotypic switching; required to establish and maintain the opaque state; opaque-specific, nuclear; regulates its own expression; suggested role in regulation of adhesion factors 5992 WOR2 Transcriptional regulator of white-opaque switching; required for maintenance of opaque state 5226 WRS1 Putative tRNA-Trp synthetase; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 5867 WSC1 Protein described as a cell wall component; increased mRNA abundance observed in cyr1 homozygous null mutant (yeast-form or hyphal cells) 7251 WSC4 Transcription is specific to white cell type 1290 XKS1 Predicted ORF in Assemblies 19, 20 and 21; increased expression in response to prostaglandins 2990 XOG1 Exo-1,3-beta-glucanase, major exoglucanase; member of family 5 glycosyl hydrolases; affects sensitivity to inhibitors of chitin and glucan synthesis; not required for yeast-to-hyphal transition or for virulence in mouse systemic infection 2882 XUT1 Putative high-affinity, high-capacity xanthine-uric acid/H+ symporter; similar to A. nidulans UapA; member of the Nucleobase-Ascorbate Transporter/Nucleobase-Cation Symporter (NAT/NCS2) family 7676 XYL2 Protein described as similar to D-xylulose reductase; immunogenic in mouse; soluble protein in hyphae; Hog1p-induced; induced during cell wall regeneration; caspofungin or fluconazole-induced; Mnl1p-induced in weak acid stress 7037 YAE1 Predicted ORF in Assemblies 19, 20 and 21 5501 YAF9 Subunit of the NuA4 histone acetyltransferase complex; transcription is regulated by Mig1p 336 YAH1 Similar to oxidoreductases; transcriptionally regulated by iron; expression greater in high iron 147 YAK1 Predicted serine-threonine protein kinase involved in hyphal growth regulation and biofilm formation; induced in core caspofungin response 4136 YBL053 Predicted ORF in Assemblies 19, 20 and 21; not essential for viability 6478 YCF1 Putative glutathione S-conjugate transporter with similarity to S. cerevisiae Ycf1p; MRP/CFTR-subfamily, ABC transporter family; human neutrophil-induced; oxidative stress-induced via Cap1p; possible association with multidrug resistance 1622 YCG1 Predicted ORF in Assemblies 19, 20 and 21 7001 YCK2 Plasma membrane protein similar to S. cerevisiae Yck2p, which is casein kinase I; null mutant has defect in damaging oral epithelial cells and in hyphal branching; transcription is activated in weak acid stress or on contact with host cells 1127 YCK3 Putative GPI-anchored protein of unknown function; removed from Assembly 20 5286 YCP4 Putative flavodoxin; fungal-specific (no human or murine homolog) 1883 YCS4 Predicted ORF in Assemblies 19, 20 and 21; cell-cycle regulated periodic mRNA expression 3104 YDC1 Predicted ORF in Assemblies 19, 20 and 21; shows Mob2p-dependent hyphal regulation; transcription is regulated by Nrg1p and Mig1p 506 YDJ1 Predicted ORF in Assemblies 19, 20 and 21; heavy metal (cadmium) stress-induced 1382 YEA4 Protein similar to S. cerevisiae Yea4p; transcription is induced in response to alpha pheromone in SpiderM medium 1413 YFH1 Frataxin; homolog of S. cerevisiae Yfh1p, mammalian frataxin; may be required for iron storage or delivery; role in oxidative stress resistance; transcription regulated by Nrg1p, repressed if iron absent, induced by macrophage interaction 3707 YHB1 Nitric oxide dioxygenase; acts in nitric oxide scavenging/detoxification; role in virulence in mouse; not essential for viability; similar to S. cerevisiae Yhb1p; transcription activated by NO, macrophage interaction; hyphal downregulated 7637 YHB4 Protein related to flavohemoglobins; not required for wild-type nitric oxide resistance; has predicted globin, FAD-binding, and NAD(P)-binding domains but lacks some conserved residues of flavohemoglobins; no mRNA detected 3710 YHB5 Protein related to flavohemoglobins; not required for wild-type nitric oxide resistance; has predicted globin, FAD-binding, and NAD(P)-binding domains but lacks some conserved residues of flavohemoglobins; mRNA detected; filament induced 685 YHM1 Putative mitochondrial carrier protein; fungal-specific (no human or murine homolog) 4197 YHM2 Alkaline upregulated 847 YIM1 Protein similar to protease of mitochondrial inner membrane; increased transcription is observed upon benomyl treatment; macrophage-downregulated gene 6601.1 YKE2 Possible cytoskeletal modulator; transcription induced upon yeast-to-hyphal switch; regulated by Nrg1p, Tup1p 2974 YKT6 Predicted ORF in Assemblies 19, 20 and 21 2383 YKU80 Protein described as DNA double-strand break repair factor 4447 YMC1 Predicted ORF in Assemblies 19, 20 and 21; flucytosine induced 4733 YMC2 Predicted ORF in Assemblies 19, 20 and 21; Gcn4p-regulated; induced upon biofilm formation 1252 YME1 Protein not essential for viability; similar to S. cerevisiae Yme1p, which is a mitochondrial inner membrane protease of the AAA family 7019 YML6 Protein described as a mitochondrial ribosomal protein; induced upon adherence to polystyrene 5713 YMX6 Protein described as NADH dehydrogenase; macrophage-downregulated gene; induced by nitric oxide 4311 YNK1 Nucleoside diphosphate kinase (NDP kinase); homo-hexameric; soluble protein in hyphae; flucytosine induced; biofilm induced; macrophage-induced protein; protein detected by mass spec in stationary phase cultures 1783 YOR1 Protein similar to S. cerevisiae Yor1p, which is a plasma membrane transporter of the ATP-binding cassette (ABC) family involved in resistance to aureobasidin A; transcription is specific to white cell type 7017 YOX1 Predicted ORF in Assemblies 19, 20 and 21; periodic mRNA expression, peak at cell-cycle G1/S phase 4443 YPD1 Phosphohistidine intermediate protein in a phosphorelay signal transduction pathway; residue His69 is the phosphoacceptor histidine; predicted to be soluble and cytosolic; functional homolog of S. cerevisiae Ypd1p 6481 YPS7 Putative aspartic-type endopeptidase with limited ability to degrade alpha pheromone; mutants show increased sensitivity to alpha pheromone 3052 YPT1 Functional homolog of S. cerevisiae Ypt1p, which is an essential small Ras-type GTPase involved in protein secretion at ER-to-Golgi; dominant-negative mutation causes SAP secretion defect and accumulation of intracellular secretory vesicles 2622 YPT31 Predicted ORF in Assemblies 19, 20 and 21 (see Locus History Note for Assembly 19 correction); mutation confers hypersensitivity to toxic ergosterol analog 2975 YPT7 Protein of YPT/RAB family; induced during the mating process 2245 YPT72 Vacuolar Rab small monomeric GTPase involved in vacuolar biogenesis; involved in filamentous growth and virulence 7477 YRB1 Functional homolog of S. cerevisiae Yrb1p, which regulates Gsp1p GTPase activity and thereby affects nucleocytoplasmic transport and cytoskeletal dynamics; transcription is not regulated by white-opaque switching or by dimorphic transition 6975 YST1 Ribosome-associated protein; antigenic in mouse; complements S. cerevisiae yst1 yst2 mutant; similar to laminin-binding proteins, but does not bind laminin; possible S/T phosphorylation, N-glycosylation, myristoylation, Gcn4p-regulated 7558 YTA6 Protein similar to S. cerevisiae Yta6p ATPase; transposon mutation affects filamentous growth; transcriptionally activated by Mnl1p under weak acid stress 6881 YTH1 Protein described as an mRNA cleavage and polyadenylation specificity factor; transcription is regulated upon yeast-hyphal switch; decreased expression in hyphae compared to yeast-form cells; fluconazole or flucytosine induced 4815 YTM1 Protein similar to S. cerevisiae Ytm1p, which is involved in biogenesis of the large ribosomal subunit; transposon mutation affects filamentous growth; protein level decreased in stationary phase cultures 3930 YUH2 Predicted ORF in Assemblies 19, 20 and 21; described as similar to ubiquitin carboxyl-terminal hydrolases 2209 YVC1 Protein similar to S. cerevisiae Yvc1p; transcription is repressed in response to alpha pheromone in SpiderM medium 4401 YVH1 Putative dual specificity phosphatase (phosphoserine/threonine and phosphotyrosine phosphatase); similar to S. cerevisiae Yvh1p; required for wild-type growth rate and for wild-type virulence in mouse model of systemic infection 3618 YWP1 Protein with suggested role in dispersal in host; mutation causes increased adhesion and biofilm formation; putative GPI-anchor; cell wall and secreted; has stable propeptide; regulated by growth phase, phosphate, Ssk1p, Ssn6p, Efg1p, Efh1p 4145 ZCF20 Predicted zinc-finger protein of unknown function 4568 ZCF25 Putative transcription factor with zinc cluster DNA-binding motif 1168 ZCF3 Predicted zinc-finger protein of unknown function 7381 ZCF37 Predicted zinc-finger protein of unknown function; not essential for viability 3823 ZDS1 Nonessential protein; similar to S. cerevisiae Zds1p 3187 ZNC1 Putative transcription factor; has Zn(2)-Cys(6) binuclear cluster; predicted to bind DNA; regulated by Gcn2p and Gcn4p; gene is located in zinc cluster region of Chromosome 5, near the MTL locus 3300 ZPR1 Protein with putative zinc finger; regulated by Gcn4p; repressed in response to amino acid starvation (3-aminotriazole treatment); upregulation correlates with clinical development of fluconazole resistance 3112 ZRT1 Protein described as zinc transporter; hyphal- and macrophage-induced; alkaline upregulated by Rim101p; induced upon adherence to polystyrene 1585 ZRT2 Protein described as predicted zinc transporter; ciclopirox olamine, fluconazole, or alkaline downregulated; transcriptionally induced by interaction with macrophage; amphotericin B induced 2709 ZUO1 Protein likely to be essential for growth, based on an insertional mutagenesis strategy; similar to S. cerevisiae Zuo1p, which is a cytosolic ribosome-associated chaperone 4754 ZWF1 Putative glucose-6-phosphate dehydrogenase; antigenic in murine infection; activity induced by O2 or oxidizing agents H2O2 or menadione; caspofungin repressed; macrophage induced; induced in core stress response; regulated by Gcn2p, Gcn4p 100 orf19.100 Predicted ORF in Assemblies 19, 20 and 21 1002 orf19.1002 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 1003 orf19.1003 Predicted ORF from Assembly 19; merged with orf19.1005 in Assembly 20 1004 orf19.1004 Predicted ORF from Assembly 19; removed from Assembly 20 1005 orf19.1005 Predicted ORF in Assemblies 19, 20 and 21; transcription is upregulated in both intermediate and mature biofilms 1006 orf19.1006 Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth; merged with orf19.562 in Assembly 20 1007 orf19.1007 Putative transcription factor with bZIP DNA-binding motif 1008 orf19.1008 Predicted ORF in Assemblies 19, 20 and 21 1009 orf19.1009 Predicted ORF in Assemblies 19, 20 and 21 1011 orf19.1011 Predicted ORF in Assemblies 19, 20 and 21 1012 orf19.1012 Predicted ORF in Assemblies 19, 20 and 21 1013 orf19.1013 Predicted ORF from Assembly 19; merged with orf19.5289 in Assembly 20 1014 orf19.1014 Predicted ORF from Assembly 19; removed from Assembly 20 1016 orf19.1016 Predicted ORF from Assembly 19; removed from Assembly 20 1017 orf19.1017 Predicted ORF from Assembly 19; removed from Assembly 20 1018 orf19.1018 Predicted ORF from Assembly 19; removed from Assembly 20 1019 orf19.1019 Predicted ORF from Assembly 19; removed from Assembly 20; merged with orf19.5718 in Assembly 21 102 orf19.102 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 1020 orf19.1020 Predicted ORF from Assembly 19; removed from Assembly 20; merged with orf19.5719 in Assembly 21 1021 orf19.1021 Predicted ORF from Assembly 19; removed from Assembly 20 1022 orf19.1022 Predicted ORF from Assembly 19; removed from Assembly 20 1023 orf19.1023 Predicted ORF from Assembly 19; possibly spurious ORF (Annotation Working Group prediction); removed from Assembly 20 1024 orf19.1024 Predicted ORF from Assembly 19; removed from Assembly 20 1025 orf19.1025 Predicted ORF from Assembly 19; removed from Assembly 20 1026 orf19.1026 Predicted ORF in Assemblies 19, 20 and 21 1026.1 orf19.1026.1 ORF added to Assembly 21 based on comparative genome analysis 1028 orf19.1028 Predicted ORF in Assemblies 19, 20 and 21 1029 orf19.1029 Predicted ORF in Assemblies 19, 20 and 21 1030 orf19.1030 Predicted ORF in Assemblies 19, 20 and 21 1034 orf19.1034 Predicted ORF in Assemblies 19, 20 and 21; caspofungin repressed 1037 orf19.1037 Predicted ORF in Assemblies 19, 20 and 21 1038 orf19.1038 Predicted ORF from Assembly 19; merged with orf19.1037 in Assembly 20 1039 orf19.1039 Predicted ORF in Assemblies 19, 20 and 21 104 orf19.104 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction); transcription is induced in response to alpha pheromone in SpiderM medium 1041 orf19.1041 Predicted ORF in Assemblies 19, 20 and 21 1043 orf19.1043 Predicted ORF in Assemblies 19, 20 and 21 1045 orf19.1045 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine) 1049 orf19.1049 Predicted ORF in Assemblies 19, 20 and 21; expression upregulated during planktonic growth 1050 orf19.1050 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 1052 orf19.1052 Predicted histone H2B 1053 orf19.1053 Predicted ORF in Assemblies 19, 20 and 21 1054 orf19.1054 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 1057 orf19.1057 Predicted ORF in Assemblies 19, 20 and 21 1058 orf19.1058 Predicted ORF in Assemblies 19, 20 and 21 1060 orf19.1060 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 1062 orf19.1062 Predicted ORF in Assemblies 19, 20 and 21 1063 orf19.1063 Predicted ORF in Assemblies 19, 20 and 21 1066 orf19.1066 Predicted ORF in Assemblies 19, 20 and 21 1068 orf19.1068 Predicted ORF from Assembly 19; removed from Assembly 20 107 orf19.107 Predicted ORF in Assemblies 19, 20 and 21 1070 orf19.1070 Predicted ORF in Assemblies 19, 20 and 21 1071 orf19.1071 Predicted ORF from Assembly 19; possibly spurious ORF (Annotation Working Group prediction); merged with orf19.5203 in Assembly 20 1072 orf19.1072 Predicted ORF from Assembly 19; removed from Assembly 20 1073 orf19.1073 Predicted ORF from Assembly 19; removed from Assembly 20 1074 orf19.1074 Predicted ORF from Assembly 19; removed from Assembly 20 1075 orf19.1075 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 1075.1 orf19.1075.1 Pseudogene; added to Assembly 21 based on comparative genome analysis 1079 orf19.1079 Predicted ORF from Assembly 19; merged with orf19.1078 in Assembly 20 1080 orf19.1080 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 1082 orf19.1082 Predicted ORF in Assemblies 19, 20 and 21 1082.1 orf19.1082.1 ORF Predicted by Annotation Working Group 1083 orf19.1083 Predicted ORF in Assemblies 19, 20 and 21; macrophage-induced gene; possibly spurious ORF (Annotation Working Group prediction) 1085 orf19.1085 Predicted ORF in Assemblies 19, 20 and 21 1086 orf19.1086 Predicted ORF in Assemblies 19, 20 and 21 1087 orf19.1087 Predicted ORF in Assemblies 19, 20 and 21 109 orf19.109 Predicted ORF in Assemblies 19, 20 and 21 1090 orf19.1090 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 1091 orf19.1091 Putative ortholog of S. cerevisiae Nop8p, which is a nucleolar protein required for 60S ribosomal subunit biogenesis 1092 orf19.1092 Predicted ORF in Assemblies 19, 20 and 21 1095 orf19.1095 Predicted ORF in Assemblies 19, 20 and 21 1096 orf19.1096 Predicted ORF in Assemblies 19, 20 and 21 1098 orf19.1098 Predicted ORF from Assembly 19; merged with orf19.1097 in Assembly 20 1099 orf19.1099 Predicted ORF from Assembly 19; removed from Assembly 20 11 orf19.11 Gene transcription regulated by Mig1p and Tup1p; possibly spurious ORF (Annotation Working Group prediction) 1100 orf19.1100 Predicted ORF from Assembly 19; removed from Assembly 20 1101 orf19.1101 Predicted ORF from Assembly 19; removed from Assembly 20 1102 orf19.1102 Predicted ORF from Assembly 19; removed from Assembly 20 1103 orf19.1103 Predicted ORF from Assembly 19; removed from Assembly 20 1104 orf19.1104 Predicted ORF from Assembly 19; removed from Assembly 20 1105 orf19.1105 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 1105.3 orf19.1105.3 ORF Predicted by Annotation Working Group 1106 orf19.1106 Predicted ORF in Assemblies 19, 20 and 21; shows Mob2p-dependent hyphal regulation; fluconazole-induced 1107 orf19.1107 Predicted ORF in Assemblies 19, 20 and 21 1109 orf19.1109 Predicted ORF in Assemblies 19, 20 and 21 1110 orf19.1110 Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate); active as a homodimer 1111 orf19.1111 Predicted ORF in Assemblies 19, 20 and 21 1113 orf19.1113 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 1114 orf19.1114 Predicted ORF in Assemblies 19, 20 and 21 1116 orf19.1116 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 1117 orf19.1117 Predicted ORF in Assemblies 19, 20 and 21; similar to Candida boidinii formate dehydrogenase; virulence-group-correlated expression 1121 orf19.1121 Predicted ORF in Assemblies 19, 20 and 21 1122 orf19.1122 Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium 1123 orf19.1123 Predicted ORF in Assemblies 19, 20 and 21 1124 orf19.1124 Predicted ORF in Assemblies 19, 20 and 21 1124.2 orf19.1124.2 Predicted ORF in Assemblies 19, 20 and 21 1125 orf19.1125 Predicted ORF from Assembly 19; merged with orf19.2165 in Assembly 20 1126 orf19.1126 Predicted ORF from Assembly 19; possibly spurious ORF (Annotation Working Group prediction); removed from Assembly 20 1128 orf19.1128 Predicted ORF from Assembly 19; removed from Assembly 20 1129 orf19.1129 Predicted ORF from Assembly 19; removed from Assembly 20 1130 orf19.1130 Predicted ORF from Assembly 19; removed from Assembly 20 1136 orf19.1136 Predicted ORF in Assemblies 19, 20 and 21 1137 orf19.1137 Predicted ORF in Assemblies 19, 20 and 21 1139 orf19.1139 Predicted ORF in Assemblies 19, 20 and 21 114 orf19.114 Predicted ORF in Assemblies 19, 20 and 21 1140 orf19.1140 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 1142 orf19.1142 Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium 1143 orf19.1143 Predicted ORF in Assemblies 19, 20 and 21 1144 orf19.1144 Predicted ORF in Assemblies 19, 20 and 21 11450 orf19.11450 Predicted ORF from Assembly 19; not essential for viability; removed from Assembly 20 1146 orf19.1146 Predicted ORF in Assemblies 19, 20 and 21 1148 orf19.1148 Predicted ORF in Assemblies 19, 20 and 21 115 orf19.115 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 1150 orf19.1150 Predicted ORF in Assemblies 19, 20 and 21; regulated by Gcn2p and Gcn4p 1150.1 orf19.1150.1 ORF Predicted by Annotation Working Group 1151 orf19.1151 Predicted ORF from Assembly 19; induced in core stress response; merged with orf19.1152 in Assembly 20 1152 orf19.1152 Predicted ORF in Assemblies 19, 20 and 21; regulated by Gcn2p and Gcn4p; induced in core stress response 1158 orf19.1158 Predicted ORF in Assemblies 19, 20 and 21 1159 orf19.1159 Predicted ORF in Assemblies 19, 20 and 21; similar to A. nidulans CYSA serine O-trans-acetylase, suggesting that C. albicans uses an O-acetyl-serine (OAS) pathway of sulfur assimilation; induced upon biofilm formation 1160 orf19.1160 Predicted ORF in Assemblies 19, 20 and 21 1162 orf19.1162 Predicted ORF in Assemblies 19, 20 and 21; increased transcription is observed upon benomyl treatment 1162.1 orf19.1162.1 ORF Predicted by Annotation Working Group 1163 orf19.1163 Predicted ORF in Assemblies 19, 20 and 21 1167 orf19.1167 Predicted ORF in Assemblies 19, 20 and 21 1169 orf19.1169 Predicted ORF in Assemblies 19, 20 and 21 117 orf19.117 Predicted ORF in Assemblies 19, 20 and 21 1171 orf19.1171 Predicted ORF in Assemblies 19, 20 and 21 1172 orf19.1172 Protein similar to phosphate transporters; regulated upon white-opaque switching or biofilm formation; Hog1p, ciclopirox olamine or alkaline induced; caspofungin or stress repressed; merged with orf19.655 in Assembly 20 1173 orf19.1173 Predicted ORF from Assembly 19; removed from Assembly 20 1174 orf19.1174 Predicted ORF from Assembly 19; merged with orf19.4173 in Assembly 20 1175 orf19.1175 Predicted ORF from Assembly 19; merged with orf19.6319 in Assembly 20 1177 orf19.1177 Predicted ORF in Assemblies 19, 20 and 21 1178 orf19.1178 Putative transcription factor with bZIP DNA-binding motif 1179 orf19.1179 Transcriptionally regulated by iron; expression greater in high iron; possibly subject to Kex2p processing 1180 orf19.1180 Predicted ORF in Assemblies 19, 20 and 21 1181 orf19.1181 Predicted ORF in Assemblies 19, 20 and 21 1182 orf19.1182 Predicted ORF in Assemblies 19, 20 and 21 1183 orf19.1183 Predicted ORF in Assemblies 19, 20 and 21 1185 orf19.1185 Predicted ORF in Assemblies 19, 20 and 21 1186 orf19.1186 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 1189 orf19.1189 Predicted ORF in Assemblies 19, 20 and 21; transcription regulated upon yeast-hyphal switch; transcriptionally activated by Mnl1p under weak acid stress 119 orf19.119 Predicted ORF in Assemblies 19, 20 and 21 1190 orf19.1190 Predicted ORF in Assemblies 19, 20 and 21 1191 orf19.1191 Predicted ORF in Assemblies 19, 20 and 21 1195 orf19.1195 Predicted ORF in Assemblies 19, 20 and 21 1196 orf19.1196 Predicted ORF in Assemblies 19, 20 and 21 1198 orf19.1198 Predicted ORF in Assemblies 19, 20 and 21 120 orf19.120 Predicted ORF from Assembly 19; removed from Assembly 20; subsequently reinstated in Assembly 21 based on comparative genome analysis 1200 orf19.1200 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 1201 orf19.1201 Predicted ORF in Assemblies 19, 20 and 21 1202 orf19.1202 Predicted ORF in Assemblies 19, 20 and 21 1203.1 orf19.1203.1 ORF Predicted by Annotation Working Group 1204 orf19.1204 Phosphorylated protein of unknown function, transcription is upregulated clinical isolates from HIV positive patients with oral candidiasis; predicted ORF in Assemblies 19, 20 and 21 1205 orf19.1205 Predicted ORF from Assembly 19; transcription is negatively regulated by Sfu1p; removed from Assembly 20 1207 orf19.1207 Predicted ORF in Assemblies 19, 20 and 21 1208 orf19.1208 Predicted ORF in Assemblies 19, 20 and 21; member of a family encoded by FGR6-related genes in the RB2 repeat sequence 1208.1 orf19.1208.1 Predicted ORF in Assembly 20; removed from Assembly 21 1209 orf19.1209 Predicted ORF from Assembly 19; merged with orf19.4557 in Assembly 20 1210 orf19.1210 Predicted ORF in Assemblies 19, 20 and 21 1211 orf19.1211 Predicted ORF from Assembly 19; removed from Assembly 20 1212 orf19.1212 Predicted ORF in Assemblies 19, 20 and 21 1214 orf19.1214 Predicted ORF in Assemblies 19, 20 and 21 1215 orf19.1215 Predicted ORF in Assemblies 19, 20 and 21 1217 orf19.1217 Predicted ORF in Assemblies 19, 20 and 21 1218 orf19.1218 Predicted ORF from Assembly 19; removed from Assembly 20 1219 orf19.1219 Predicted ORF in Assemblies 19, 20 and 21 1222 orf19.1222 Predicted ORF from Assembly 19; merged with orf19.2631 in Assembly 20 1225 orf19.1225 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 1226 orf19.1226 Predicted ORF from Assembly 19; merged with orf19.2778 in Assembly 20 1227 orf19.1227 Putative transcription factor with zinc cluster DNA-binding motif; possibly spurious ORF (Annotation Working Group prediction) 1229 orf19.1229 Predicted ORF in Assemblies 19, 20 and 21 123 orf19.123 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 1230 orf19.1230 Predicted ORF from Assembly 19; merged with orf19.1229 in Assembly 20 1231 orf19.1231 Predicted ORF from Assembly 19; merged with orf19.1229 in Assembly 20 1236 orf19.1236 Predicted ORF in Assemblies 19, 20 and 21 1239 orf19.1239 Predicted ORF in Assemblies 19, 20 and 21; exogenously expressed protein is a substrate for Kex2p processing in vitro; fluconazole-downregulated; possibly spurious ORF (Annotation Working Group prediction) 1240 orf19.1240 Predicted ORF in Assemblies 19, 20 and 21; fungal-specific (no human or murine homolog) 1246 orf19.1246 Predicted ORF in Assemblies 19, 20 and 21; greater mRNA abundance observed in a cyr1 homozygous null mutant than in wild type 1247 orf19.1247 Predicted ORF in Assemblies 19, 20 and 21 1248 orf19.1248 Putative protein of unknown function; heterozygous null mutant exhibits resistance to parnafungin in the C. albicans fitness test; predicted ORF in Assemblies 19, 20 and 21 1249 orf19.1249 Predicted ORF in Assemblies 19, 20 and 21 1250 orf19.1250 Predicted ORF in Assemblies 19, 20 and 21 1253 orf19.1253 Predicted ORF in Assemblies 19, 20 and 21; transcriptionally activated by Mnl1p under weak acid stress 1255 orf19.1255 Putative transcription factor with zinc cluster DNA-binding motif; shows colony morphology-related gene regulation by Ssn6p 1256 orf19.1256 Predicted ORF from Assembly 19; merged with orf19.1255 in Assembly 20 1257 orf19.1257 Predicted ORF in Assemblies 19, 20 and 21 1258 orf19.1258 Predicted ORF in Assemblies 19, 20 and 21; regulated by Tsa1p, Tsa1Bp in minimal media at 37 deg; transcription is induced in response to alpha pheromone in SpiderM medium; clade-associated gene expression 1259 orf19.1259 Predicted ORF in Assemblies 19, 20 and 21 126 orf19.126 Predicted ORF from Assembly 19; merged with orf19.130 in Assembly 20 1265 orf19.1265 Predicted ORF in Assemblies 19, 20 and 21 1266 orf19.1266 Predicted ORF in Assemblies 19, 20 and 21 1267 orf19.1267 Predicted ORF in Assemblies 19, 20 and 21 1267.1 orf19.1267.1 ORF Predicted by Annotation Working Group 1268 orf19.1268 Predicted ORF in Assemblies 19, 20 and 21 127 orf19.127 Predicted ORF from Assembly 19; merged with orf19.130 in Assembly 20 1270 orf19.1270 Predicted ORF in Assemblies 19, 20 and 21; similar to ferric reductase Fre10p 1272 orf19.1272 Predicted ORF in Assemblies 19, 20 and 21 1273 orf19.1273 Predicted ORF in Assemblies 19, 20 and 21 1274 orf19.1274 Predicted ORF in Assemblies 19, 20 and 21 1276 orf19.1276 Predicted ORF in Assemblies 19, 20 and 21; not essential for viability; similar to S. cerevisiae Vhs3p, which is a putative phosphopantothenoylcysteine decarboxylase 1277 orf19.1277 Predicted ORF in Assemblies 19, 20 and 21; repressed by Rgt1p 1278 orf19.1278 Predicted ORF from Assembly 19; merged with orf19.4403 in Assembly 20 1281 orf19.1281 Predicted ORF in Assemblies 19, 20 and 21 1285 orf19.1285 Predicted ORF in Assemblies 19, 20 and 21 1286 orf19.1286 Predicted ORF in Assemblies 19, 20 and 21 1287 orf19.1287 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 129 orf19.129 Predicted ORF from Assembly 19; merged with orf19.130 in Assembly 20 1293 orf19.1293 Predicted ORF from Assembly 19; merged with orf19.2629 in Assembly 20 1294 orf19.1294 Predicted ORF from Assembly 19; merged with orf19.2629 in Assembly 20 1296 orf19.1296 Predicted ORF in Assemblies 19, 20 and 21 1297 orf19.1297 Predicted ORF in Assemblies 19, 20 and 21 1298 orf19.1298 Predicted ORF in Assemblies 19, 20 and 21 13 orf19.13 Putative glucokinase; regulated upon yeast-hyphal switch; regulated by Efg1p; fluconazole-induced; induced in core stress response; shows colony morphology-related gene regulation by Ssn6p; merged with orf19.734 in Assembly 20 130 orf19.130 Predicted ORF in Assemblies 19, 20 and 21 1300 orf19.1300 Predicted ORF in Assemblies 19, 20 and 21 1301 orf19.1301 Predicted ORF in Assemblies 19, 20 and 21 1302 orf19.1302 Predicted ORF in Assemblies 19, 20 and 21 1303 orf19.1303 Predicted ORF in Assemblies 19, 20 and 21 1304 orf19.1304 Predicted ORF in Assemblies 19, 20 and 21 1305 orf19.1305 Predicted ORF in Assemblies 19, 20 and 21 1306 orf19.1306 Predicted ORF in Assemblies 19, 20 and 21 1307 orf19.1307 Predicted ORF in Assemblies 19, 20 and 21 1308 orf19.1308 Predicted membrane transporter, member of the drug:proton antiporter (14 spanner) (DHA2) family, major facilitator superfamily (MFS) 1309 orf19.1309 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 131 orf19.131 Predicted ORF in Assemblies 19, 20 and 21 131.2 orf19.131.2 ORF Predicted by Annotation Working Group 1310 orf19.1310 Predicted ORF in Assemblies 19, 20 and 21 1312 orf19.1312 Predicted ORF from Assembly 19; orf19.1312 and orf19.1313 may be a single ORF; merged with orf19.1313 in Assembly 20 1314 orf19.1314 Predicted ORF in Assemblies 19, 20 and 21 1318 orf19.1318 Predicted ORF in Assemblies 19, 20 and 21 132 orf19.132 Putative ortholog of S. cerevisiae SIF2; has a LisH motif; predicted ORF in Assemblies 19, 20 and 21 1323 orf19.1323 Phosphorylated protein of unknown function; predicted ORF in Assemblies 19, 20 and 21 1326 orf19.1326 Predicted ORF in Assemblies 19, 20 and 21 1329 orf19.1329 Predicted ORF from Assembly 19; merged with orf19.6704 in Assembly 20 133 orf19.133 Predicted ORF in Assemblies 19, 20 and 21; induced by nitric oxide in yhb1 mutant 1330 orf19.1330 Predicted ORF in Assemblies 19, 20 and 21 1334 orf19.1334 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction); transcription is repressed in response to alpha pheromone in SpiderM medium 1335 orf19.1335 Predicted ORF in Assemblies 19, 20 and 21 1336.2 orf19.1336.2 ORF Predicted by Annotation Working Group 1338 orf19.1338 Predicted ORF in Assemblies 19, 20 and 21 134 orf19.134 Predicted ORF in Assemblies 19, 20 and 21; ciclopirox olamine induced 1340 orf19.1340 Predicted ORF in Assemblies 19, 20 and 21; protein level decreased in stationary phase cultures 1343 orf19.1343 Predicted ORF in Assemblies 19, 20 and 21; induced by nitric oxide 1344 orf19.1344 Predicted ORF in Assemblies 19, 20 and 21; fluconazole-induced; possibly spurious ORF (Annotation Working Group prediction) 1346 orf19.1346 Cell wall protein; expression is repressed by Rim101p; merged with orf19.5124 in Assembly 20 1347 orf19.1347 Predicted ORF from Assembly 19; gene fragment (probable assembly 19 error); 3' end of OPT5 (oligopeptide transporter); merged with orf19.5121 in Assembly 20 1348 orf19.1348 Predicted ORF in Assemblies 19, 20 and 21 1349 orf19.1349 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 135 orf19.135 Predicted ORF in Assemblies 19, 20 and 21 1350 orf19.1350 Predicted ORF in Assemblies 19, 20 and 21 1351 orf19.1351 Predicted ORF in Assemblies 19, 20 and 21 1352 orf19.1352 Predicted ORF in Assemblies 19, 20 and 21 1353 orf19.1353 Predicted ORF in Assemblies 19, 20 and 21; transcription downregulated upon yeast-hyphal switch; Ras1p-regulated 1355 orf19.1355 Predicted ORF in Assemblies 19, 20 and 21; protein detected by mass spec in stationary phase cultures 1356 orf19.1356 Predicted ORF in Assemblies 19, 20 and 21 1359 orf19.1359 Predicted ORF in Assemblies 19, 20 and 21 136 orf19.136 Predicted membrane transporter, member of the drug:proton antiporter (12 spanner) (DHA1) family, major facilitator superfamily (MFS) 1360 orf19.1360 Predicted ORF in Assemblies 19, 20 and 21 1360.1 orf19.1360.1 ORF Predicted by Annotation Working Group 1361 orf19.1361 Predicted ORF in Assemblies 19, 20 and 21 1363 orf19.1363 Predicted ORF in Assemblies 19, 20 and 21; Plc1p-regulated; transcriptionally activated by Mnl1p under weak acid stress 1364 orf19.1364 Predicted ORF in Assemblies 19, 20 and 21; constitutive expression independent of MTL or white-opaque status 1365 orf19.1365 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to toxic ergosterol analog; constitutive expression independent of MTL or white-opaque status 1366 orf19.1366 Predicted ORF in Assemblies 19, 20 and 21 1367.1 orf19.1367.1 ORF added to Assembly 21 based on comparative genome analysis 1368 orf19.1368 Predicted ORF in Assemblies 19, 20 and 21 1369 orf19.1369 Predicted ORF in Assemblies 19, 20 and 21 137 orf19.137 Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium 1370 orf19.1370 Predicted ORF in Assemblies 19, 20 and 21; expression is regulated upon white-opaque switching; transcription is repressed in response to alpha pheromone in SpiderM medium 1371 orf19.1371 Predicted ORF in Assemblies 19, 20 and 21 1372 orf19.1372 Gene transcription regulated by Mig1p and Tup1p 1374 orf19.1374 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 1376 orf19.1376 Predicted ORF in Assemblies 19, 20 and 21 1381 orf19.1381 Predicted ORF in Assemblies 19, 20 and 21 1383 orf19.1383 Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium 1384 orf19.1384 Predicted ORF from Assembly 19; merged with orf19.1383 in Assembly 20 1386 orf19.1386 Predicted ORF in Assemblies 19, 20 and 21 1387 orf19.1387 Predicted ORF in Assemblies 19, 20 and 21 1388 orf19.1388 Predicted ORF in Assemblies 19, 20 and 21; induced upon biofilm formation 1389 orf19.1389 Predicted ORF in Assemblies 19, 20 and 21 1391 orf19.1391 Predicted ORF in Assemblies 19, 20 and 21 1392 orf19.1392 Predicted ORF in Assemblies 19, 20 and 21 1393 orf19.1393 Predicted ORF in Assemblies 19, 20 and 21 1394 orf19.1394 Protein not essential for viability; protein level decreased in stationary phase cultures 1395 orf19.1395 Predicted ORF in Assemblies 19, 20 and 21 1396 orf19.1396 Predicted ORF in Assemblies 19, 20 and 21 1397 orf19.1397 Predicted ORF in Assemblies 19, 20 and 21 14 orf19.14 Predicted ORF from Assembly 19; removed from Assembly 20 140 orf19.140 Predicted ORF from Assembly 19; possibly spurious ORF (Annotation Working Group prediction); removed from Assembly 20 1400 orf19.1400 Predicted ORF in Assemblies 19, 20 and 21 1403 orf19.1403 Predicted ORF in Assemblies 19, 20 and 21 1404 orf19.1404 Predicted ORF in Assemblies 19, 20 and 21 1406 orf19.1406 Predicted ORF in Assemblies 19, 20 and 21 1407 orf19.1407 Predicted ORF from Assembly 19; merged with orf19.6117 in Assembly 20 1408 orf19.1408 Predicted ORF from Assembly 19; merged with orf19.6116 in Assembly 20 1409.1 orf19.1409.1 Predicted ORF in Assembly 20 and 21; gene has intron 1409.2 orf19.1409.2 ORF added to Assembly 21 based on comparative genome analysis 1409.3 orf19.1409.3 ORF added to Assembly 21 based on comparative genome analysis 141 orf19.141 Predicted ORF from Assembly 19; removed from Assembly 20 1411 orf19.1411 Predicted ORF in Assemblies 19, 20 and 21 1412 orf19.1412 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 1414 orf19.1414 Putative protein of unknown function, transcription is upregulated in an RHE model of oral candidiasis; predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 1417 orf19.1417 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 1419 orf19.1419 Predicted ORF from Assembly 19; merged with orf19.1418 in Assembly 20 1420 orf19.1420 Predicted ORF in Assemblies 19, 20 and 21 1421 orf19.1421 Predicted ORF in Assemblies 19, 20 and 21 1424 orf19.1424 Predicted membrane transporter, member of the oxalate:formate antiporter (OFA) family, major facilitator superfamily (MFS) 1426 orf19.1426 Predicted ORF in Assemblies 19, 20 and 21 1427 orf19.1427 Putative transporter; fungal-specific (no human or murine homolog) 1428 orf19.1428 Predicted ORF in Assemblies 19, 20 and 21 1430 orf19.1430 Predicted ORF in Assemblies 19, 20 and 21 1431 orf19.1431 Predicted ORF from Assembly 19; removed from Assembly 20 1432 orf19.1432 Predicted ORF from Assembly 19; removed from Assembly 20 1433 orf19.1433 Predicted ORF in Assemblies 19, 20 and 21; shows colony morphology-related gene regulation by Ssn6p 1433.1 orf19.1433.1 ORF added to Assembly 21 based on comparative genome analysis; overlaps orf19.1433.2, which is annotated as a blocked reading frame 1433.2 orf19.1433.2 Region annotated in Assembly 21 as a blocked reading frame, based on comparative genome analysis; overlaps orf19.1433.1, which is an open reading frame 1434 orf19.1434 Predicted ORF in Assemblies 19, 20 and 21 1437 orf19.1437 Transcription is negatively regulated by Sfu1p; removed from Assembly 20 1438 orf19.1438 Predicted ORF in Assemblies 19, 20 and 21 1440 orf19.1440 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 1440.1 orf19.1440.1 ORF added to Assembly 21 based on comparative genome analysis 1440.2 orf19.1440.2 ORF added to Assembly 21 based on comparative genome analysis 1441 orf19.1441 Predicted ORF in Assemblies 19, 20 and 21 1444 orf19.1444 Predicted ORF in Assemblies 19, 20 and 21 1447 orf19.1447 Predicted ORF in Assemblies 19, 20 and 21 1448.1 orf19.1448.1 Predicted ORF in Assembly 20 and 21; gene has intron 1449 orf19.1449 Increased transcription is observed in an azole-resistant strain that overexpresses MDR1; protein detected by mass spec in exponential and stationary phase cultures 1450 orf19.1450 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 1456 orf19.1456 ORF Predicted by Annotation Working Group; possibly spurious ORF (Annotation Working Group prediction) 1457 orf19.1457 Predicted ORF in Assemblies 19, 20 and 21 1458 orf19.1458 Predicted ORF in Assemblies 19, 20 and 21 146 orf19.146 Predicted ORF from Assembly 19; merged with orf19.145 in Assembly 20 1460 orf19.1460 Putative glutamine-dependent NAD synthetase, involved in NAD salvage pathway 1461 orf19.1461 Predicted ORF in Assemblies 19, 20 and 21; possibly transcriptionally regulated upon hyphal formation 1465 orf19.1465 Predicted ORF in Assemblies 19, 20 and 21 1468 orf19.1468 Predicted ORF in Assemblies 19, 20 and 21 1469 orf19.1469 Predicted ORF from Assembly 19; removed from Assembly 20 1473 orf19.1473 Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium 1476 orf19.1476 Predicted ORF in Assemblies 19, 20 and 21 1477 orf19.1477 Predicted ORF in Assemblies 19, 20 and 21 1478 orf19.1478 Predicted ORF in Assemblies 19, 20 and 21 1479 orf19.1479 Predicted ORF in Assemblies 19, 20 and 21 148 orf19.148 Predicted ORF from Assembly 19; induced in core caspofungin response; merged with orf19.147 in Assembly 20 1480 orf19.1480 Protein described as succinate dehydrogenase, enzyme of citric acid cycle; downregulated by Efg1p; repressed by nitric oxide 1482 orf19.1482 Predicted ORF in Assemblies 19, 20 and 21; expression regulated during planktonic growth 1483 orf19.1483 Predicted ORF in Assemblies 19, 20 and 21 1484 orf19.1484 Predicted ORF in Assemblies 19, 20 and 21 1485 orf19.1485 Predicted ORF in Assemblies 19, 20 and 21 1486 orf19.1486 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 1487 orf19.1487 Predicted ORF from Assembly 19; removed from Assembly 20 1488 orf19.1488 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 149 orf19.149 Predicted ORF in Assemblies 19, 20 and 21 1490.1 orf19.1490.1 Predicted ORF in retrotransposon Tca16 with similarity to the Gag-Pol region of retrotransposons; added to Assembly 21 based on comparative genome analysis; overlaps orf19.1490.2, which is annotated as blocked reading frame 1490.2 orf19.1490.2 Predicted ORF in retrotransposon Tca16 with similarity to the Gag-Pol region of retrotransposons; annotated in Assembly 21 as a blocked reading frame, based on comparative genome analysis; overlaps an open reading frame orf19.1490.1 1491 orf19.1491 Predicted ORF in Assemblies 19, 20 and 21 1495 orf19.1495 Predicted ORF in Assemblies 19, 20 and 21 1496 orf19.1496 Putative transcription factor with zinc finger DNA-binding motif; possibly spurious ORF (Annotation Working Group prediction) 1497 orf19.1497 Putative transcription factor with zinc cluster DNA-binding motif 15 orf19.15 Predicted ORF from Assembly 19; removed from Assembly 20 150 orf19.150 Predicted ORF in Assemblies 19, 20 and 21 1500 orf19.1500 Predicted ORF in Assemblies 19, 20 and 21 1502 orf19.1502 Predicted ORF in Assemblies 19, 20 and 21 1504 orf19.1504 Putative patatin-like phospholipase; fungal-specific (no human or murine homolog) 1505 orf19.1505 Predicted ORF in Assemblies 19, 20 and 21 1506 orf19.1506 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 1507 orf19.1507 Predicted ORF in Assemblies 19, 20 and 21; Plc1p-regulated 1508 orf19.1508 Predicted ORF in Assemblies 19, 20 and 21 1510 orf19.1510 Protein not essential for viability 1514 orf19.1514 Predicted ORF in Assemblies 19, 20 and 21 1516 orf19.1516 Predicted ORF in Assemblies 19, 20 and 21 1519 orf19.1519 Predicted ORF in Assemblies 19, 20 and 21 1522 orf19.1522 Predicted ORF in Assemblies 19, 20 and 21 1525 orf19.1525 Predicted ORF in Assemblies 19, 20 and 21 1527 orf19.1527 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 1528 orf19.1528 Predicted ORF in Assemblies 19, 20 and 21 1529 orf19.1529 Predicted ORF in Assemblies 19, 20 and 21; macrophage-induced gene; possibly spurious ORF (Annotation Working Group prediction) 153 orf19.153 Predicted ORF from Assembly 19; merged with orf19.151 in Assembly 20 1530 orf19.1530 Predicted ORF in Assemblies 19, 20 and 21 1531 orf19.1531 Predicted ORF in Assemblies 19, 20 and 21 1532 orf19.1532 Predicted ORF in Assemblies 19, 20 and 21 1533 orf19.1533 Predicted ORF in Assemblies 19, 20 and 21 1534 orf19.1534 Protein similar to S. cerevisiae Zrt3p, which is a transporter of zinc ions; predicted Kex2p substrate 1535 orf19.1535 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 1536 orf19.1536 Predicted ORF in Assemblies 19, 20 and 21 1537 orf19.1537 Predicted ORF from Assembly 19; merged with orf19.1536 in Assembly 20 1539 orf19.1539 Predicted ORF in Assemblies 19, 20 and 21; highly induced upon biofilm formation 154 orf19.154 Predicted ORF in Assemblies 19, 20 and 21 1541 orf19.1541 Protein not essential for viability; transcription is repressed in response to alpha pheromone in SpiderM medium 1544 orf19.1544 Predicted ORF in Assemblies 19, 20 and 21 1545 orf19.1545 Predicted ORF in Assemblies 19, 20 and 21 1546 orf19.1546 Predicted ORF in Assemblies 19, 20 and 21 1547 orf19.1547 Predicted ORF in Assemblies 19, 20 and 21 1548 orf19.1548 Predicted ORF in Assemblies 19, 20 and 21 1549 orf19.1549 Predicted ORF in Assemblies 19, 20 and 21; repressed by nitric oxide; identified in detergent-resistant membrane fraction (possible lipid raft component); predicted transmembrane helix 1551 orf19.1551 Predicted ORF in Assemblies 19, 20 and 21 1556 orf19.1556 Predicted ORF from Assembly 19; merged with orf19.1555 in Assembly 20 1557 orf19.1557 Predicted ORF in Assemblies 19, 20 and 21 1562 orf19.1562 Predicted ORF in Assemblies 19, 20 and 21; transcription is repressed in response to alpha pheromone in SpiderM medium 1564 orf19.1564 Predicted ORF in Assemblies 19, 20 and 21 1565 orf19.1565 Putative transcription factor with zinc finger DNA-binding motif 1567 orf19.1567 Predicted ORF in Assemblies 19, 20 and 21 1568 orf19.1568 Predicted ORF from Assembly 19; merged with orf19.1567 in Assembly 20 157 orf19.157 Predicted ORF from Assembly 19; merged with orf19.156 in Assembly 20 1571 orf19.1571 Predicted ORF in Assemblies 19, 20 and 21 1572 orf19.1572 Predicted ORF from Assembly 19; merged with orf19.1571 in Assembly 20 1573 orf19.1573 Predicted ORF in Assemblies 19, 20 and 21 1574 orf19.1574 Predicted ORF in Assemblies 19, 20 and 21 1576 orf19.1576 Predicted ORF in Assemblies 19, 20 and 21 1577 orf19.1577 Predicted ORF in Assemblies 19, 20 and 21 1578 orf19.1578 Predicted ORF in Assemblies 19, 20 and 21 158 orf19.158 Predicted ORF in Assemblies 19, 20 and 21 1580 orf19.1580 Predicted ORF in Assemblies 19, 20 and 21 1581 orf19.1581 Predicted ORF in Assemblies 19, 20 and 21 1582 orf19.1582 Predicted membrane transporter, member of the drug:proton antiporter (12 spanner) (DHA1) family, major facilitator superfamily (MFS) 1583 orf19.1583 Predicted ORF from Assembly 19; merged with orf19.1582 in Assembly 20 1584 orf19.1584 Predicted membrane transporter, member of the monocarboxylate porter (MCP) family, major facilitator superfamily (MFS); shows colony morphology-related gene regulation by Ssn6p 1588 orf19.1588 Predicted ORF in Assemblies 19, 20 and 21 1589 orf19.1589 Putative DNA-binding transcription factor 1589.1 orf19.1589.1 ORF added to Assembly 21 based on comparative genome analysis 159 orf19.159 Predicted ORF from Assembly 19; removed from Assembly 20 1590 orf19.1590 Predicted ORF in Assemblies 19, 20 and 21 1592 orf19.1592 Predicted ORF in Assemblies 19, 20 and 21 1593 orf19.1593 Protein not essential for viability; similar to S. cerevisiae Rim11p, which is a protein kinase involved in meiosis and sporulation; merged with orf19.791 in Assembly 20 1594 orf19.1594 Predicted ORF from Assembly 19; possibly spurious ORF (Annotation Working Group prediction); merged with orf19.792 in Assembly 20 1595 orf19.1595 Predicted ORF in Assemblies 19, 20 and 21 1599 orf19.1599 Predicted ORF in Assemblies 19, 20 and 21 16 orf19.16 Predicted ORF from Assembly 19; removed from Assembly 20 160 orf19.160 Predicted ORF from Assembly 19; removed from Assembly 20 1600 orf19.1600 Predicted ORF in Assemblies 19, 20 and 21 1604 orf19.1604 Predicted ORF in Assemblies 19, 20 and 21; Gal4p-like DNA-binding domain 1606 orf19.1606 Predicted ORF in Assemblies 19, 20 and 21; Plc1p-regulated 1608 orf19.1608 Predicted ORF in Assemblies 19, 20 and 21 1609 orf19.1609 Predicted ORF in Assemblies 19, 20 and 21 1610 orf19.1610 Putative protein of unknown function, transcription is activated in the presence of elevated CO2; predicted ORF in Assemblies 19, 20 and 21 1611 orf19.1611 Predicted ORF in Assemblies 19, 20 and 21 1617 orf19.1617 Protein similar to S. cerevisiae Ydr282cp; transposon mutation affects filamentous growth 1618.1 orf19.1618.1 ORF added to Assembly 21 based on comparative genome analysis 1619 orf19.1619 Predicted ORF in Assemblies 19, 20 and 21 162 orf19.162 Predicted ORF from Assembly 19; removed from Assembly 20 1620 orf19.1620 Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium 1624 orf19.1624 Predicted ORF in Assemblies 19, 20 and 21 1624.1 orf19.1624.1 ORF added to Assembly 21 based on comparative genome analysis 1625 orf19.1625 Predicted ORF in Assemblies 19, 20 and 21; repressed by nitric oxide 1626 orf19.1626 Predicted ORF in Assemblies 19, 20 and 21 163 orf19.163 Predicted ORF in Assemblies 19, 20 and 21 1630 orf19.1630 Predicted ORF in Assemblies 19, 20 and 21 1632 orf19.1632 Predicted ORF in Assemblies 19, 20 and 21 1634 orf19.1634 Predicted ORF in Assemblies 19, 20 and 21 1637 orf19.1637 Predicted ORF in Assemblies 19, 20 and 21 1638 orf19.1638 Predicted ORF in Assemblies 19, 20 and 21 164 orf19.164 Predicted ORF in Assemblies 19, 20 and 21 1640 orf19.1640 Predicted ORF from Assembly 19; merged with orf19.1639 in Assembly 20 1641 orf19.1641 Predicted ORF in Assemblies 19, 20 and 21 1642 orf19.1642 Predicted ORF in Assemblies 19, 20 and 21 1643 orf19.1643 Predicted ORF in Assemblies 19, 20 and 21 1646 orf19.1646 Predicted ORF in Assemblies 19, 20 and 21 1647 orf19.1647 Predicted ORF in Assemblies 19, 20 and 21 1650 orf19.1650 Predicted ORF in Assemblies 19, 20 and 21 1651 orf19.1651 Predicted ORF in Assemblies 19, 20 and 21 1653 orf19.1653 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 1654 orf19.1654 Predicted ORF in Assemblies 19, 20 and 21; increased expression in response to prostaglandins 1655.3 orf19.1655.3 ORF Predicted by Annotation Working Group 1656 orf19.1656 Predicted ORF in Assemblies 19, 20 and 21 1657 orf19.1657 Predicted ORF from Assembly 19; merged with orf19.1658 in Assembly 20 1658 orf19.1658 Predicted ORF in Assemblies 19, 20 and 21 1660 orf19.1660 Predicted ORF from Assembly 19; removed from Assembly 20 1661 orf19.1661 Predicted ORF in Assemblies 19, 20 and 21 1662 orf19.1662 Predicted ORF in Assemblies 19, 20 and 21 1664 orf19.1664 Predicted ORF in Assemblies 19, 20 and 21; decreased expression observed in an ssr1 homozygous null mutant 1666 orf19.1666 Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium 1667 orf19.1667 Predicted ORF in Assemblies 19, 20 and 21 1667.1 orf19.1667.1 ORF Predicted by Annotation Working Group 1668 orf19.1668 Predicted ORF in Assemblies 19, 20 and 21; decreased expression observed in an ssr1 homozygous null mutant; possibly spurious ORF (Annotation Working Group prediction) 167 orf19.167 Predicted ORF from Assembly 19; merged with orf19.166 in Assembly 20 1672 orf19.1672 Predicted ORF in Assemblies 19, 20 and 21 1675 orf19.1675 Predicted ORF in Assemblies 19, 20 and 21 1676 orf19.1676 Predicted ORF in Assemblies 19, 20 and 21 1677 orf19.1677 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 1678 orf19.1678 Predicted ORF in Assemblies 19, 20 and 21 1679 orf19.1679 Predicted ORF in Assemblies 19, 20 and 21 168 orf19.168 Predicted ORF in Assemblies 19, 20 and 21 1680 orf19.1680 Predicted ORF in Assemblies 19, 20 and 21; protein detected by mass spec in stationary phase cultures 1681 orf19.1681 Predicted ORF in Assemblies 19, 20 and 21 1682 orf19.1682 Predicted ORF in Assemblies 19, 20 and 21; repressed by nitric oxide 1684 orf19.1684 Predicted ORF in Assemblies 19, 20 and 21 1685 orf19.1685 Predicted zinc-finger protein of unknown function 1686 orf19.1686 Predicted ORF in Assemblies 19, 20 and 21 1687 orf19.1687 Predicted ORF in Assemblies 19, 20 and 21 1691 orf19.1691 Predicted ORF in Assemblies 19, 20 and 21; fluconazole-induced; filament induced; Hog1p-induced; regulated by Nrg1p, Tup1p; increased expression in response to prostaglandins 1694 orf19.1694 Putative transcription factor with zinc finger DNA-binding motif; merged with orf19.1693 in Assembly 20 1697 orf19.1697 Predicted ORF in Assemblies 19, 20 and 21 1698 orf19.1698 Predicted ORF in Assemblies 19, 20 and 21 170 orf19.170 Predicted ORF from Assembly 19; flucytosine induced; downregulated in core stress response; merged with orf19.171 in Assembly 20 1707 orf19.1707 Predicted ORF in Assemblies 19, 20 and 21 1708 orf19.1708 Predicted ORF in Assemblies 19, 20 and 21 1709 orf19.1709 Predicted ORF in Assemblies 19, 20 and 21; alkaline downregulated; shows colony morphology-related gene regulation by Ssn6p 1710 orf19.1710 Protein described as NADH-ubiquinone oxidoreductase; identified in detergent-resistant membrane fraction (possible lipid raft component); predicted N-terminal acetylation; repressed by nitric oxide 1713 orf19.1713 Protein described as an ARF GTP/GDP exchange factor; transcriptionally regulated by iron; expression greater in low iron; merged with orf19.1712 in Assembly 20 1717 orf19.1717 Predicted ORF in Assemblies 19, 20 and 21 1718 orf19.1718 Predicted zinc-finger protein of unknown function; decreased transcription is observed upon fluphenazine treatment 1720 orf19.1720 Predicted ORF in Assemblies 19, 20 and 21 1722 orf19.1722 Predicted ORF in Assemblies 19, 20 and 21 1723 orf19.1723 Predicted ORF in Assemblies 19, 20 and 21 1724 orf19.1724 Predicted ORF in Assemblies 19, 20 and 21; induced by nitric oxide in yhb1 mutant 1725 orf19.1725 Predicted ORF in Assemblies 19, 20 and 21 1728 orf19.1728 Predicted ORF in Assemblies 19, 20 and 21 1729 orf19.1729 Putative transcription factor with zinc finger DNA-binding motif; possibly spurious ORF (Annotation Working Group prediction) 173 orf19.173 Putative transcription factor with zinc finger DNA-binding motif; transcriptionally activated by Mnl1p under weak acid stress 1730 orf19.1730 Predicted ORF in Assemblies 19, 20 and 21 1731 orf19.1731 Predicted ORF from Assembly 19; merged with orf19.1730 in Assembly 20 1732 orf19.1732 Predicted ORF from Assembly 19; downregulated in core stress response; merged with orf19.3159 in Assembly 20 1733 orf19.1733 Predicted ORF from Assembly 19; downregulated in core stress response; merged with orf19.3159 in Assembly 20 1734 orf19.1734 Predicted ORF in Assemblies 19, 20 and 21; heterozygous null mutant displays sensitivity to virgineone 1735 orf19.1735 Predicted ORF in Assemblies 19, 20 and 21 1736 orf19.1736 Predicted ORF in Assemblies 19, 20 and 21 1737 orf19.1737 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 1738.1 orf19.1738.1 ORF Predicted by Annotation Working Group 174 orf19.174 Predicted ORF from Assembly 19; merged with orf19.173 in Assembly 20 1741 orf19.1741 Predicted ORF in Assemblies 19, 20 and 21 1745 orf19.1745 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 1746 orf19.1746 Predicted ORF in Assemblies 19, 20 and 21; similar to S. cerevisiae meiosis-specific, spore-wall-localized protein Ssp2p, which is required for wild-type formation of outer spore wall in S. cerevisiae 1748 orf19.1748 Predicted ORF in Assemblies 19, 20 and 21; shows colony morphology-related gene regulation by Ssn6p 175 orf19.175 Predicted ORF in Assemblies 19, 20 and 21 1750 orf19.1750 Predicted ORF in Assemblies 19, 20 and 21; similar to mammalian SR-like RNA splicing factor; gene has intron; significant changes made to ORF with coordinate updates (see Locus History) 1754 orf19.1754 Predicted ORF in Assemblies 19, 20 and 21 1755 orf19.1755 Predicted ORF in Assemblies 19, 20 and 21 1757 orf19.1757 Putative transcription factor with zinc finger DNA-binding motif; transcription is upregulated in clinical isolates from HIV+ patients with oral candidiasis 1761 orf19.1761 Predicted ORF in Assemblies 19, 20 and 21 1764 orf19.1764 Predicted ORF in Assemblies 19, 20 and 21 1765 orf19.1765 Predicted ORF in Assemblies 19, 20 and 21 1766 orf19.1766 Predicted ORF in Assemblies 19, 20 and 21 1767 orf19.1767 Predicted ORF in Assemblies 19, 20 and 21 1768 orf19.1768 Predicted ORF in Assemblies 19, 20 and 21 1769 orf19.1769 Predicted ORF in Assemblies 19, 20 and 21 177 orf19.177 Predicted ORF in Assemblies 19, 20 and 21 1771 orf19.1771 Predicted ORF in Assemblies 19, 20 and 21 1772 orf19.1772 Predicted ORF in Assemblies 19, 20 and 21 1774 orf19.1774 Predicted ORF in Assemblies 19, 20 and 21; transcription is upregulated in an RHE model of oral candidiasis; virulence-group-correlated expression 1775 orf19.1775 Predicted ORF from Assembly 19; merged with orf19.1774 in Assembly 20 1776 orf19.1776 Predicted ORF in Assemblies 19, 20 and 21 1777 orf19.1777 Predicted ORF in Assemblies 19, 20 and 21 1778 orf19.1778 Predicted ORF in Assemblies 19, 20 and 21 178 orf19.178 Predicted ORF in Assemblies 19, 20 and 21 1780 orf19.1780 Predicted ORF in Assemblies 19, 20 and 21 1781 orf19.1781 Predicted ORF from Assembly 19; removed from Assembly 20 1782 orf19.1782 Predicted ORF in Assemblies 19, 20 and 21 1782.1 orf19.1782.1 ORF added to Assembly 21 based on comparative genome analysis; has intron 1784 orf19.1784 Protein similar to S. cerevisiae Yor1p, a plasma membrane transporter of the ATP-binding cassette (ABC) family involved in resistance to aureobasidin A; orf19.1783 and orf19.1784 may be a single ORF; merged with orf19.1783 in Assembly 20 1785 orf19.1785 Predicted ORF in Assemblies 19, 20 and 21 1786 orf19.1786 Predicted ORF from Assembly 19; merged with orf19.1291 in Assembly 20 1787 orf19.1787 Predicted ORF from Assembly 19; merged with orf19.1291 in Assembly 20 1788 orf19.1788 Predicted ORF from Assembly 19; merged with orf19.1290 in Assembly 20 1789 orf19.1789 Predicted ORF in Assemblies 19, 20 and 21 179 orf19.179 Predicted ORF from Assembly 19; merged with orf19.2370 in Assembly 20 1790 orf19.1790 Predicted ORF from Assembly 19; merged with orf19.1789.1 in Assembly 20 1791 orf19.1791 Predicted ORF in Assemblies 19, 20 and 21 1792 orf19.1792 Predicted ORF in Assemblies 19, 20 and 21 1793 orf19.1793 Protein not essential for viability 1794 orf19.1794 Predicted ORF in Assemblies 19, 20 and 21 1795.1 orf19.1795.1 ORF added to Assembly 21 based on comparative genome analysis 1796 orf19.1796 Predicted ORF in Assemblies 19, 20 and 21 1797 orf19.1797 Predicted ORF in Assemblies 19, 20 and 21; induced upon biofilm formation; has GutQ domain, which is associated with phosphosugar binding 1799 orf19.1799 Putative general amino acid permease; fungal-specific (no human or murine homolog) 180 orf19.180 Predicted ORF from Assembly 19; removed from Assembly 20 1800 orf19.1800 Predicted ORF in Assemblies 19, 20 and 21 1801 orf19.1801 Predicted ORF in Assemblies 19, 20 and 21 1802 orf19.1802 Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins 1804 orf19.1804 Predicted ORF in Assemblies 19, 20 and 21 1806 orf19.1806 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 1808 orf19.1808 Putative protein of unknown function, transcription is positively regulated by Tbf1p; predicted ORF in Assemblies 19, 20 and 21 1809 orf19.1809 Predicted 3-hydroxyacyl-CoA epimerase; upregulated upon phagocytosis; transcription is regulated by Mig1p; expression is regulated upon white-opaque switching; merged with orf19.1288 in Assembly 20 181 orf19.181 Predicted ORF from Assembly 19; merged with orf19.4128 in Assembly 20 1812 orf19.1812 Predicted ORF from Assembly 19; merged with orf19.3071 in Assembly 20 1814 orf19.1814 Predicted ORF in Assemblies 19, 20 and 21 1815 orf19.1815 Predicted ORF in Assemblies 19, 20 and 21 1817 orf19.1817 Predicted ORF from Assembly 19; removed from Assembly 20 1818 orf19.1818 Predicted ORF from Assembly 19; possibly spurious ORF (Annotation Working Group prediction); removed from Assembly 20 182 orf19.182 Predicted ORF in Assemblies 19, 20 and 21 1820 orf19.1820 Predicted ORF from Assembly 19; removed from Assembly 20 1821 orf19.1821 Predicted ORF in Assemblies 19, 20 and 21; transcription is repressed in response to alpha pheromone in SpiderM medium 1823 orf19.1823 Predicted ORF in Assemblies 19, 20 and 21; transcription is downregulated in response to treatment with ciclopirox olamine 1825 orf19.1825 Protein not essential for viability; filament induced; regulated by Nrg1p, Rfg1p, Tup1p 1827 orf19.1827 Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium 1829 orf19.1829 Predicted ORF from Assembly 19; merged with orf19.2663 in Assembly 20 1830 orf19.1830 Predicted ORF in Assemblies 19, 20 and 21 1831 orf19.1831 Predicted ORF in Assemblies 19, 20 and 21 1833 orf19.1833 Predicted ORF in Assemblies 19, 20 and 21 1834 orf19.1834 Predicted ORF in Assemblies 19, 20 and 21 1835 orf19.1835 Predicted ORF in Assemblies 19, 20 and 21 184 orf19.184 Predicted ORF in Assemblies 19, 20 and 21 1840 orf19.1840 Predicted ORF in Assemblies 19, 20 and 21 1841 orf19.1841 Predicted ORF in Assemblies 19, 20 and 21 1842 orf19.1842 Predicted ORF in Assemblies 19, 20 and 21 1844 orf19.1844 Predicted ORF in Assemblies 19, 20 and 21; similar to ferric reductase Fre10p 1845 orf19.1845 Predicted ORF from Assembly 19; merged with orf19.1844 in Assembly 20 1848.1 orf19.1848.1 ORF Predicted by Annotation Working Group 1849 orf19.1849 Predicted ORF in Assemblies 19, 20 and 21 185 orf19.185 Predicted ORF in Assemblies 19, 20 and 21 1852 orf19.1852 Predicted ORF in Assemblies 19, 20 and 21 1855 orf19.1855 Predicted membrane transporter, member of the anion:cation symporter (ACS) family, major facilitator superfamily (MFS); Gcn4p-regulated; flucytosine induced; ketoconazole-repressed; oxidative stress-induced via Cap1p 1856 orf19.1856 Predicted ORF in Assemblies 19, 20 and 21 1857 orf19.1857 Protein not essential for viability 1859 orf19.1859 Predicted ORF from Assembly 19; removed from Assembly 20 1860.1 orf19.1860.1 Predicted ORF in Assemblies 19, 20 and 21 1861 orf19.1861 Predicted ORF in Assemblies 19, 20 and 21 1862 orf19.1862 Possible stress protein; increased transcription is associated with CDR1 and CDR2 overexpression or fluphenazine treatment; transcription regulated by Sfu1p, Nrg1p, Tup1p 1863 orf19.1863 Predicted ORF in Assemblies 19, 20 and 21 1864 orf19.1864 Predicted ORF in Assemblies 19, 20 and 21 1865 orf19.1865 Predicted ORF in Assemblies 19, 20 and 21 1866 orf19.1866 Predicted ORF in Assemblies 19, 20 and 21 1867 orf19.1867 Putative malate permease; induced during macrophage infection; regulated by Gcn2p and Gcn4p; has putative peroxisome targeting signal 1869 orf19.1869 Predicted ORF from Assembly 19; removed from Assembly 20 187 orf19.187 Predicted ORF in Assemblies 19, 20 and 21; merged with orf19.188 in Assembly 21 1871 orf19.1871 Predicted ORF in Assemblies 19, 20 and 21 1872 orf19.1872 Predicted ORF in Assemblies 19, 20 and 21; repressed by nitric oxide 1873 orf19.1873 Predicted ORF in Assemblies 19, 20 and 21; repressed by nitric oxide; possibly spurious ORF (Annotation Working Group prediction) 1874 orf19.1874 Predicted ORF in Assemblies 19, 20 and 21 1875 orf19.1875 Predicted ORF from Assembly 19; merged with orf19.1874 in Assembly 20 1876 orf19.1876 Predicted ORF in Assemblies 19, 20 and 21 1877 orf19.1877 Predicted ORF in Assemblies 19, 20 and 21 1878 orf19.1878 Predicted ORF in Assemblies 19, 20 and 21 188 orf19.188 Predicted ORF in Assemblies 19, 20 and 21; merged with orf19.187 in Assembly 21 1881 orf19.1881 Predicted ORF in Assemblies 19, 20 and 21 1887 orf19.1887 Predicted ORF in Assemblies 19, 20 and 21 1888 orf19.1888 Predicted ORF in Assemblies 19, 20 and 21 1889 orf19.1889 Predicted ORF in Assemblies 19, 20 and 21; protein detected by mass spec in stationary phase cultures 1890 orf19.1890 Predicted ORF in Assemblies 19, 20 and 21 1892 orf19.1892 Predicted ORF from Assembly 19; removed from Assembly 20 1893 orf19.1893 Predicted ORF in Assemblies 19, 20 and 21 1897 orf19.1897 Predicted ORF in Assemblies 19, 20 and 21 1899 orf19.1899 Predicted ORF from Assembly 19; removed from Assembly 20 19 orf19.19 Predicted ORF from Assembly 19; downregulated in core stress response; merged with orf19.18 in Assembly 20 190 orf19.190 Predicted ORF in Assemblies 19, 20 and 21 1900 orf19.1900 Predicted ORF in Assemblies 19, 20 and 21 1903 orf19.1903 Protein similar to TOR family phosphatidylinositol kinases; mutation confers resistance to rapamycin; merged with orf19.2290 in Assembly 20 1904 orf19.1904 Predicted ORF from Assembly 19; removed from Assembly 20 1905 orf19.1905 Predicted ORF from Assembly 19; merged with orf19.2290 in Assembly 20 1906 orf19.1906 Predicted ORF in Assemblies 19, 20 and 21 1910 orf19.1910 Predicted ORF in Assemblies 19, 20 and 21 1913 orf19.1913 Predicted ORF in Assemblies 19, 20 and 21 1917 orf19.1917 Predicted ORF in Assemblies 19, 20 and 21 192 orf19.192 Predicted ORF in Assemblies 19, 20 and 21 1920 orf19.1920 Predicted ORF in Assemblies 19, 20 and 21 1928 orf19.1928 Predicted ORF from Assembly 19; transcription is negatively regulated by Sfu1p; removed from Assembly 20 193 orf19.193 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 1933 orf19.1933 Predicted ORF in Assemblies 19, 20 and 21 1934 orf19.1934 Predicted ORF in Assemblies 19, 20 and 21; repressed upon high-level peroxide stress 1935 orf19.1935 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 1938 orf19.1938 Decreased transcription is observed in an azole-resistant strain that overexpresses CDR1 and CDR2; increased transcription is observed upon benomyl treatment 1939 orf19.1939 Predicted ORF in Assemblies 19, 20 and 21 194 orf19.194 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 1940 orf19.1940 Predicted ORF in Assemblies 19, 20 and 21 1943 orf19.1943 Predicted ORF in Assemblies 19, 20 and 21 1946 orf19.1946 Similar to an aldose 1-epimerase-related protein; antigenic during murine systemic infection; protein detected by mass spec in exponential and stationary phase cultures 1948 orf19.1948 Predicted ORF in Assemblies 19, 20 and 21 195 orf19.195 Predicted ORF from Assembly 19; possibly spurious ORF (Annotation Working Group prediction); merged with orf19.156 in Assembly 20 1950 orf19.1950 Predicted ORF in Assemblies 19, 20 and 21 1952 orf19.1952 Protein not essential for viability; merged with orf19.1953 in Assembly 21 1953 orf19.1953 Predicted ORF in Assemblies 19, 20 and 21; not essential for viability; merged with orf19.1952 in Assembly 21 1955 orf19.1955 Predicted ORF in Assemblies 19, 20 and 21 1956 orf19.1956 Predicted ORF in Assemblies 19, 20 and 21 1958 orf19.1958 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 1959 orf19.1959 Predicted ORF in Assemblies 19, 20 and 21 196 orf19.196 Predicted ORF from Assembly 19; merged with orf19.4066 in Assembly 20 1961 orf19.1961 Predicted ORF in Assemblies 19, 20 and 21 1963 orf19.1963 Predicted ORF in Assemblies 19, 20 and 21 1964 orf19.1964 Putative protein of unknown function; downregulated upon fluphenazine treatment; upregulated upon benomyl treatment and in an RHE model; regulated by Nrg1p, Tup1p 1967 orf19.1967 Predicted ORF in Assemblies 19, 20 and 21 1968 orf19.1968 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 1968.1 orf19.1968.1 ORF Predicted by Annotation Working Group 1970 orf19.1970 Predicted ORF in Assemblies 19, 20 and 21 1971 orf19.1971 Predicted ORF in Assemblies 19, 20 and 21 1972 orf19.1972 Predicted ORF in Assemblies 19, 20 and 21 1975 orf19.1975 Predicted ORF in Assemblies 19, 20 and 21 1981 orf19.1981 Predicted ORF in Assemblies 19, 20 and 21 1982 orf19.1982 Predicted ORF from Assembly 19; merged with orf19.588 in Assembly 20 1983 orf19.1983 Predicted ORF from Assembly 19; merged with orf19.587 in Assembly 20 1984 orf19.1984 Predicted ORF from Assembly 19; merged with orf19.1985 in Assembly 20 1985 orf19.1985 Predicted ORF in Assemblies 19, 20 and 21 199 orf19.199 Predicted ORF in Assemblies 19, 20 and 21; hyphal-induced expression; greater mRNA abundance observed in a cyr1 homozygous null mutant than in wild type 1991 orf19.1991 Predicted ORF in Assemblies 19, 20 and 21 1993 orf19.1993 Predicted ORF in Assemblies 19, 20 and 21 1994 orf19.1994 Predicted ORF in Assemblies 19, 20 and 21 1995 orf19.1995 Predicted ORF in Assemblies 19, 20 and 21 1997 orf19.1997 Predicted ORF from Assembly 19; merged with orf19.1996 in Assembly 20 1998 orf19.1998 Predicted ORF in Assemblies 19, 20 and 21 1999 orf19.1999 Predicted ORF in Assemblies 19, 20 and 21 200 orf19.200 Predicted ORF in Assemblies 19, 20 and 21 2000 orf19.2000 Predicted ORF in Assemblies 19, 20 and 21 2001 orf19.2001 Predicted ORF in Assemblies 19, 20 and 21 2002 orf19.2002 Predicted ORF in Assemblies 19, 20 and 21 2006 orf19.2006 Predicted ORF in Assemblies 19, 20 and 21 2007 orf19.2007 Predicted ORF in Assemblies 19, 20 and 21 2008 orf19.2008 Predicted ORF in Assemblies 19, 20 and 21 2009 orf19.2009 Predicted ORF in Assemblies 19, 20 and 21 201 orf19.201 Predicted ORF in Assemblies 19, 20 and 21; unmerged from orf19.202 in a revision of Assembly 21 2010 orf19.2010 Predicted ORF in Assemblies 19, 20 and 21 2015 orf19.2015 Predicted ORF from Assembly 19; merged with orf19.2014 in Assembly 20 2016 orf19.2016 Predicted ORF in Assemblies 19, 20 and 21 2017 orf19.2017 Predicted ORF in Assemblies 19, 20 and 21 2018 orf19.2018 Predicted ORF in Assemblies 19, 20 and 21 2018.1 orf19.2018.1 Predicted ORF in Assembly 20 and 21; gene has intron; similar to human BLOC1S2 2018.2 orf19.2018.2 ORF added to Assembly 21 based on comparative genome analysis 2019 orf19.2019 Predicted ORF in Assemblies 19, 20 and 21 2022 orf19.2022 Predicted ORF from Assembly 19; merged with orf19.2021 in Assembly 20 2024 orf19.2024 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 2025 orf19.2025 Predicted ORF in Assemblies 19, 20 and 21 2026 orf19.2026 Predicted ORF in Assemblies 19, 20 and 21 2030 orf19.2030 Predicted ORF in Assemblies 19, 20 and 21; greater mRNA abundance observed in a cyr1 or ras1 homozygous null mutant than in wild type 2032 orf19.2032 Predicted ORF in Assemblies 19, 20 and 21 2034 orf19.2034 Predicted ORF in Assemblies 19, 20 and 21 2035 orf19.2035 Predicted ORF in Assemblies 19, 20 and 21 2036 orf19.2036 Predicted ORF in Assemblies 19, 20 and 21 2037 orf19.2037 Predicted ORF in Assemblies 19, 20 and 21 2038 orf19.2038 Predicted ORF in Assemblies 19, 20 and 21 204 orf19.204 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 2040 orf19.2040 Predicted ORF in Assemblies 19, 20 and 21 2041 orf19.2041 Predicted ORF in Assemblies 19, 20 and 21 2042 orf19.2042 Predicted ORF in Assemblies 19, 20 and 21 2043 orf19.2043 Predicted ORF in Assemblies 19, 20 and 21 2045 orf19.2045 Predicted ORF in Assemblies 19, 20 and 21 2047 orf19.2047 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to toxic ergosterol analog, and to amphotericin B 2048 orf19.2048 Transcription is positively regulated by Sfu1p 2049 orf19.2049 Predicted ORF in Assemblies 19, 20 and 21; heterozygous null mutant displays sensitivity to virgineone 2050 orf19.2050 Predicted ORF in Assemblies 19, 20 and 21 2051 orf19.2051 Predicted ORF in Assemblies 19, 20 and 21 2053 orf19.2053 Predicted ORF from Assembly 19; merged with orf19.2051 in Assembly 20 2057 orf19.2057 Predicted ORF in Assemblies 19, 20 and 21 2059 orf19.2059 Predicted ORF in Assemblies 19, 20 and 21 206 orf19.206 Predicted ORF in Assemblies 19, 20 and 21 2061 orf19.2061 Protein not essential for viability 2063 orf19.2063 Predicted ORF in Assemblies 19, 20 and 21 2064 orf19.2064 Putative transcription factor with zinc finger DNA-binding motif 2065 orf19.2065 Predicted ORF in Assemblies 19, 20 and 21 2066 orf19.2066 Predicted ORF in Assemblies 19, 20 and 21 2066.1 orf19.2066.1 Predicted ORF in Assembly 20 and 21; gene has intron 2067 orf19.2067 Predicted ORF in Assemblies 19, 20 and 21 2068 orf19.2068 Predicted ORF in Assemblies 19, 20 and 21 2070 orf19.2070 Predicted ORF in Assemblies 19, 20 and 21 2071 orf19.2071 Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium 2072 orf19.2072 Predicted ORF in Assemblies 19, 20 and 21 2073 orf19.2073 Predicted ORF in Assemblies 19, 20 and 21; transcriptionally activated by Mnl1p under weak acid stress 2074 orf19.2074 Predicted ORF in Assemblies 19, 20 and 21 2076 orf19.2076 Predicted ORF in Assemblies 19, 20 and 21 2077 orf19.2077 Putative transcription factor with zinc cluster DNA-binding motif; hypersensitive to toxic ergosterol analog ECC69 and/or ECC1384 2078 orf19.2078 Predicted ORF in Assemblies 19, 20 and 21 2081 orf19.2081 Predicted ORF in Assemblies 19, 20 and 21 2087 orf19.2087 Predicted ORF in Assemblies 19, 20 and 21 2088 orf19.2088 Predicted ORF in Assemblies 19, 20 and 21 2089 orf19.2089 Predicted ORF in Assemblies 19, 20 and 21 2090 orf19.2090 Predicted ORF in Assemblies 19, 20 and 21 2091 orf19.2091 Predicted ORF in Assemblies 19, 20 and 21; repressed by nitric oxide 2092 orf19.2092 Predicted ORF in Assemblies 19, 20 and 21; Gcn4p-regulated 2095 orf19.2095 Predicted ORF in Assemblies 19, 20 and 21 2097 orf19.2097 Predicted ORF in Assemblies 19, 20 and 21 2099 orf19.2099 Predicted ORF in Assemblies 19, 20 and 21 21 orf19.21 Predicted ORF in Assemblies 19, 20 and 21 210 orf19.210 Predicted ORF in Assemblies 19, 20 and 21 2101 orf19.2101 Predicted ORF in Assemblies 19, 20 and 21 2103 orf19.2103 ORF Predicted by Annotation Working Group; possibly spurious ORF (Annotation Working Group prediction) 2104 orf19.2104 Predicted ORF in Assemblies 19, 20 and 21 2105 orf19.2105 Predicted ORF in Assemblies 19, 20 and 21 2106 orf19.2106 Predicted ORF in Assemblies 19, 20 and 21 211 orf19.211 Predicted ORF in Assemblies 19, 20 and 21 2110 orf19.2110 Predicted ORF in Assemblies 19, 20 and 21 2111 orf19.2111 Predicted ORF in Assemblies 19, 20 and 21 2112 orf19.2112 Predicted ORF in Assemblies 19, 20 and 21 2113 orf19.2113 Predicted ORF in Assemblies 19, 20 and 21 2114 orf19.2114 Predicted ORF in Assemblies 19, 20 and 21 2115 orf19.2115 Putative molybdopterin-converting factor; fungal-specific (no human or murine homolog) 2120 orf19.2120 Predicted ORF from Assembly 19; removed from Assembly 20 2121 orf19.2121 Predicted ORF from Assembly 19; merged with orf19.1097 in Assembly 20 2123 orf19.2123 Predicted ORF from Assembly 19; removed from Assembly 20 2124 orf19.2124 Predicted ORF in Assemblies 19, 20 and 21 2125 orf19.2125 Predicted ORF in Assemblies 19, 20 and 21 2125.1 orf19.2125.1 ORF Predicted by Annotation Working Group; removed from Assembly 20 2126 orf19.2126 Predicted ORF from Assembly 19; merged with orf19.2127 in Assembly 20 2127 orf19.2127 Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium 2128 orf19.2128 Predicted ORF in Assemblies 19, 20 and 21 2129 orf19.2129 Predicted ORF in Assemblies 19, 20 and 21 213 orf19.213 Predicted ORF in Assemblies 19, 20 and 21 2131 orf19.2131 Predicted ORF in Assemblies 19, 20 and 21 2132 orf19.2132 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 2136 orf19.2136 Predicted ORF from Assembly 19; merged with orf19.2135 in Assembly 20 2137 orf19.2137 Predicted ORF in Assemblies 19, 20 and 21 2143 orf19.2143 Predicted ORF in Assemblies 19, 20 and 21 2146 orf19.2146 Predicted ORF in Assemblies 19, 20 and 21 2149 orf19.2149 Predicted ORF in Assemblies 19, 20 and 21 215 orf19.215 Predicted ORF in Assemblies 19, 20 and 21 2150 orf19.2150 Predicted ORF in Assemblies 19, 20 and 21 2159 orf19.2159 Protein of major facilitator superfamily; transcriptionally regulated by iron; expression greater in high iron; merged with orf19.2158 in Assembly 20 216 orf19.216 Predicted ORF in Assemblies 19, 20 and 21; ketoconazole-induced; upregulation correlates with clinical development of fluconazole resistance 216.1 orf19.216.1 ORF added to Assembly 21 based on comparative genome analysis 2163 orf19.2163 Predicted ORF in Assemblies 19, 20 and 21 2164 orf19.2164 Transcription is a-specific, alpha-factor induced; merged with orf19.2219 in Assembly 20 2165 orf19.2165 Predicted ORF in Assemblies 19, 20 and 21; induced by nitric oxide 2166 orf19.2166 Predicted ORF in Assemblies 19, 20 and 21 2167 orf19.2167 Predicted ORF in Assemblies 19, 20 and 21 2168 orf19.2168 Predicted ORF in Assemblies 19, 20 and 21 2168.3 orf19.2168.3 ORF Predicted by Annotation Working Group 2169 orf19.2169 Predicted ORF in Assemblies 19, 20 and 21 217 orf19.217 Predicted ORF in Assemblies 19, 20 and 21 2175 orf19.2175 Predicted ORF in Assemblies 19, 20 and 21; induced by nitric oxide 2177 orf19.2177 ORF Predicted by Annotation Working Group 2178 orf19.2178 Predicted ORF in Assemblies 19, 20 and 21 2178.1 orf19.2178.1 ORF added to Assembly 21 based on comparative genome analysis 2180 orf19.2180 Predicted ORF in Assemblies 19, 20 and 21 2181 orf19.2181 ORF Predicted by Annotation Working Group 2184 orf19.2184 Predicted ORF in Assemblies 19, 20 and 21; clade-associated gene expression 2186 orf19.2186 Predicted ORF in Assemblies 19, 20 and 21 2191 orf19.2191 Predicted ORF in Assemblies 19, 20 and 21 2191.1 orf19.2191.1 ORF added to Assembly 21 based on comparative genome analysis 2194 orf19.2194 Phosphorylated protein of unknown function; predicted ORF in Assemblies 19, 20 and 21 2195 orf19.2195 ORF Predicted by Annotation Working Group 2196 orf19.2196 Predicted ORF in Assemblies 19, 20 and 21 2197 orf19.2197 Predicted ORF in Assemblies 19, 20 and 21 22 orf19.22 Transcription is positively regulated by Sfu1p; possibly spurious ORF (Annotation Working Group prediction) 22.1 orf19.22.1 Pseudogene; added to Assembly 21 based on comparative genome analysis 2200 orf19.2200 Predicted ORF in Assemblies 19, 20 and 21 2201 orf19.2201 Predicted ORF in Assemblies 19, 20 and 21 2202 orf19.2202 Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium 2203 orf19.2203 Predicted ORF in Assemblies 19, 20 and 21 2203.1 orf19.2203.1 ORF added to Assembly 21 based on comparative genome analysis; overlaps dubious orf19.2203 2204 orf19.2204 Predicted ORF in Assemblies 19, 20 and 21 2204.2 orf19.2204.2 ORF Predicted by Annotation Working Group (see Locus History Note for Assembly 19 correction) 2208 orf19.2208 Predicted ORF in Assemblies 19, 20 and 21 2210 orf19.2210 Predicted ORF in Assemblies 19, 20 and 21 2211 orf19.2211 Predicted ORF in Assemblies 19, 20 and 21 2212 orf19.2212 Predicted ORF in Assemblies 19, 20 and 21 2213 orf19.2213 Predicted ORF in Assemblies 19, 20 and 21 2214 orf19.2214 Predicted ORF in Assemblies 19, 20 and 21 2217 orf19.2217 Predicted ORF from Assembly 19; merged with orf19.1860.1 in Assembly 20 2218 orf19.2218 Predicted ORF from Assembly 19; merged with orf19.1861 in Assembly 20 2220 orf19.2220 Predicted ORF in Assemblies 19, 20 and 21; induced by Rgt1p 2221 orf19.2221 Predicted ORF from Assembly 19; merged with orf19.2222 in Assembly 20 2222 orf19.2222 Predicted ORF in Assemblies 19, 20 and 21 2222.1 orf19.2222.1 ORF Predicted by Annotation Working Group; merged with orf19.2660 in Assembly 20 2223 orf19.2223 Predicted ORF from Assembly 19; removed from Assembly 20 2224 orf19.2224 Predicted ORF from Assembly 19; possibly spurious ORF (Annotation Working Group prediction); removed from Assembly 20; merged with orf19.934 in Assembly 21 2225 orf19.2225 Predicted ORF from Assembly 19; removed from Assembly 20; merged with orf19.933 in Assembly 21 2226 orf19.2226 Predicted ORF from Assembly 19; removed from Assembly 20; merged with orf19.932 in Assembly 21 2227 orf19.2227 Predicted ORF in Assemblies 19, 20 and 21; repressed by nitric oxide 2228 orf19.2228 Predicted ORF in Assemblies 19, 20 and 21 2229 orf19.2229 Predicted ORF in Assemblies 19, 20 and 21 223 orf19.223 Predicted ORF in Assemblies 19, 20 and 21; increased expression in response to prostaglandins 2230 orf19.2230 Decreased transcription is observed upon benomyl treatment 2231 orf19.2231 Predicted ORF in Assemblies 19, 20 and 21 2237.1 orf19.2237.1 Predicted ORF in Assembly 20 and 21; gene has intron 2239 orf19.2239 Predicted ORF from Assembly 19; merged with orf19.2238 in Assembly 20 224 orf19.224 Predicted ORF from Assembly 19; removed from Assembly 20 2240 orf19.2240 Predicted ORF from Assembly 19; induced by nitric oxide in yhb1 mutant; removed from Assembly 20 2244 orf19.2244 Similar to oxidoreductases and to S. cerevisiae Yjr096wp; transcription is negatively regulated by Sfu1p; increased transcription is observed upon benomyl treatment; decreased expression observed in an ssr1 homozygous null mutant 2246 orf19.2246 Predicted ORF in Assemblies 19, 20 and 21 2247 orf19.2247 Predicted ORF in Assemblies 19, 20 and 21 2249 orf19.2249 Predicted ORF in Assemblies 19, 20 and 21; decreased expression observed in an ssr1 homozygous null mutant 225 orf19.225 Predicted ORF in Assemblies 19, 20 and 21 2252 orf19.2252 Predicted ORF in Assemblies 19, 20 and 21 2253 orf19.2253 Predicted ORF in Assemblies 19, 20 and 21; expression is regulated upon white-opaque switching; transcription is repressed in response to alpha pheromone in SpiderM medium 2256 orf19.2256 Predicted ORF in Assemblies 19, 20 and 21 2257 orf19.2257 Predicted ORF in Assemblies 19, 20 and 21 2258 orf19.2258 Predicted ORF in Assemblies 19, 20 and 21 2259 orf19.2259 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 226 orf19.226 Predicted ORF from Assembly 19; removed from Assembly 20 2260 orf19.2260 Putative transcription factor with zinc finger DNA-binding motif 2261 orf19.2261 Predicted ORF in Assemblies 19, 20 and 21 2262 orf19.2262 Predicted ORF in Assemblies 19, 20 and 21; similar to quinone oxidoreductases; increased transcription is observed upon benomyl treatment; induced by nitric oxide; oxidative stress-induced via Cap1p 2263 orf19.2263 Predicted ORF in Assemblies 19, 20 and 21 2265 orf19.2265 Predicted ORF in Assemblies 19, 20 and 21 2266 orf19.2266 Predicted ORF in Assemblies 19, 20 and 21 2269 orf19.2269 Putative 3-phosphoserine phosphatase; fungal-specific (no human or murine homolog); increased transcription is observed upon benomyl treatment or in an azole-resistant strain that overexpresses MDR1 2272 orf19.2272 Predicted ORF in Assemblies 19, 20 and 21 2274 orf19.2274 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 2275 orf19.2275 Predicted ORF in Assemblies 19, 20 and 21 2276 orf19.2276 Predicted ORF in Assemblies 19, 20 and 21 2278 orf19.2278 Predicted ORF in Assemblies 19, 20 and 21; filament induced; transcription is induced in response to alpha pheromone in SpiderM medium 2280 orf19.2280 Putative transcription factor with zinc cluster DNA-binding motif 2281 orf19.2281 Predicted ORF in Assemblies 19, 20 and 21 2282 orf19.2282 Predicted ORF in Assemblies 19, 20 and 21 2284 orf19.2284 Predicted ORF in Assemblies 19, 20 and 21 2285 orf19.2285 Increased transcription is observed upon benomyl treatment 2286 orf19.2286 Predicted ORF in Assemblies 19, 20 and 21; ketoconazole-induced; protein level decreased in stationary phase cultures 229 orf19.229 Predicted ORF in Assemblies 19, 20 and 21 2291 orf19.2291 Predicted ORF from Assembly 19; possibly spurious ORF (Annotation Working Group prediction); merged with orf19.3719 in Assembly 20 2292 orf19.2292 Oligopeptide transporter; transcriptionally induced upon phagocytosis by macrophage; fungal-specific (no human or murine homolog); merged with orf19.176 in Assembly 20 2293 orf19.2293 Predicted ORF from Assembly 19; merged with orf19.175 in Assembly 20 2294 orf19.2294 Predicted ORF from Assembly 19; merged with orf19.175 in Assembly 20 2294.1 orf19.2294.1 ORF Predicted by Annotation Working Group; removed from Assembly 20 2295 orf19.2295 Predicted ORF from Assembly 19; removed from Assembly 20 2296 orf19.2296 Predicted ORF in Assemblies 19, 20 and 21; similar to mucins; ketoconazole-induced; fluconazole-downregulated; greater mRNA abundance observed in a cyr1 homozygous null mutant than in wild type; colony morphology-related gene regulation by Ssn6p 2298 orf19.2298 Predicted ORF in Assemblies 19, 20 and 21 2299 orf19.2299 Predicted ORF in Assemblies 19, 20 and 21 230 orf19.230 Predicted ORF in Assemblies 19, 20 and 21 2301 orf19.2301 Predicted ORF in Assemblies 19, 20 and 21 2302 orf19.2302 Predicted ORF in Assemblies 19, 20 and 21 2304 orf19.2304 Protein similar to S. cerevisiae Yil041wp; transposon mutation affects filamentous growth 2305 orf19.2305 Predicted ORF in Assemblies 19, 20 and 21 2306 orf19.2306 Predicted ORF in Assemblies 19, 20 and 21 2307 orf19.2307 Predicted ORF in Assemblies 19, 20 and 21 2308 orf19.2308 Predicted ORF in Assemblies 19, 20 and 21 2309 orf19.2309 Predicted ORF in Assemblies 19, 20 and 21 2310 orf19.2310 Predicted ORF in Assemblies 19, 20 and 21 2312 orf19.2312 Predicted ORF in Assemblies 19, 20 and 21; similar to ferric reductase Fre10p 2313 orf19.2313 Predicted ORF in Assemblies 19, 20 and 21 2314 orf19.2314 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine) 2315 orf19.2315 Putative transcription factor with bZIP DNA-binding motif 2317 orf19.2317 Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium 2318.1 orf19.2318.1 ORF Predicted by Annotation Working Group 2319 orf19.2319 Predicted ORF in Assemblies 19, 20 and 21; downregulated in core stress response 232 orf19.232 Predicted ORF in Assemblies 19, 20 and 21 2320 orf19.2320 Predicted ORF in Assemblies 19, 20 and 21 2322.3 orf19.2322.3 ORF Predicted by Annotation Working Group 2323 orf19.2323 Predicted ORF from Assembly 19; removed from Assembly 20 2325 orf19.2325 Predicted ORF in Assemblies 19, 20 and 21 2326 orf19.2326 Predicted ORF in Assemblies 19, 20 and 21 2328 orf19.2328 Predicted ORF in Assemblies 19, 20 and 21 233 orf19.233 Predicted ORF from Assembly 19; removed from Assembly 20 2330 orf19.2330 Predicted ORF in Assemblies 19, 20 and 21; transposon mutation affects filamentous growth; decreased expression in response to prostaglandins 2332 orf19.2332 Predicted ORF in Assemblies 19, 20 and 21 2333 orf19.2333 Predicted ORF in Assemblies 19, 20 and 21 2335 orf19.2335 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to 5-fluorouracil (5-FU); Hog1p-induced; protein detected by mass spec in stationary phase cultures 2336 orf19.2336 Predicted ORF in Assemblies 19, 20 and 21 2343.1 orf19.2343.1 Pseudogene; added to Assembly 21 based on comparative genome analysis 2346 orf19.2346 Putative protein of unknown function, transcription is positively regulated by Tbf1p; predicted ORF in Assemblies 19, 20 and 21 2348 orf19.2348 Predicted ORF from Assembly 19; not essential for viability; removed from Assembly 20 2350 orf19.2350 Protein similar to S. cerevisiae Yor0378wp; transposon mutation affects filamentous growth; not essential for viability; member of MFS family of transporters; fungal-specific (no human or murine homolog) 2352 orf19.2352 Predicted ORF in Assemblies 19, 20 and 21 2353 orf19.2353 Predicted ORF from Assembly 19; merged with orf19.1840 in Assembly 20 2358 orf19.2358 Predicted ORF from Assembly 19; removed from Assembly 20 2361 orf19.2361 Predicted ORF in Assemblies 19, 20 and 21 2362 orf19.2362 Predicted ORF in Assemblies 19, 20 and 21 2363 orf19.2363 Predicted ORF in Assemblies 19, 20 and 21 2366 orf19.2366 Predicted ORF in Assemblies 19, 20 and 21 2367 orf19.2367 Protein of unknown function; transcription is negatively regulated by Rim101p 2368 orf19.2368 Predicted ORF in Assemblies 19, 20 and 21 2369 orf19.2369 Predicted ORF in Assemblies 19, 20 and 21 2371 orf19.2371 Putative Gag protein of retrotransposon Tca2; separated by a stop codon from Pol protein orf19.2372; both likely translated as single polyprotein that includes nucleocapsid-like protein (Gag), reverse transcriptase, protease, and integrase 2372 orf19.2372 Putative Pol protein of retrotransposon Tca2; separated by a stop codon from Gag protein orf19.2371; both likely translated as single polyprotein that includes nucleocapsid-like protein (Gag), reverse transcriptase, protease, and integrase 2374 orf19.2374 Predicted ORF from Assembly 19; removed from Assembly 20 2375 orf19.2375 Predicted ORF from Assembly 19; orf19.2371, orf19.2372, and orf19.2375 are similar to the Tca2 (pCal) retrotransposon, which is present in strain hOG1042 as 50 to 100 copies of a linear dsDNA; removed from Assembly 20 2376 orf19.2376 Predicted ORF in Assemblies 19, 20 and 21 2378 orf19.2378 Predicted ORF in Assemblies 19, 20 and 21 2381 orf19.2381 Predicted ORF in Assemblies 19, 20 and 21 2382 orf19.2382 Predicted ORF in Assemblies 19, 20 and 21; similar to isoleucyl-tRNA synthetase; isoleucyl-tRNA synthetase is the target of drugs including the cyclic beta-amino acid icofungipen/PLD-118/BAY-10-8888 and mupirocin 2384 orf19.2384 Predicted ORF in Assemblies 19, 20 and 21 2386 orf19.2386 Predicted ORF in Assemblies 19, 20 and 21 2387 orf19.2387 Putative tRNA-Pro synthetase; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 2389 orf19.2389 Predicted ORF in Assemblies 19, 20 and 21 239 orf19.239 Predicted ORF in Assemblies 19, 20 and 21; induced by nitric oxide 2391 orf19.2391 Predicted ORF in Assemblies 19, 20 and 21 2392 orf19.2392 Protein not essential for viability 2393 orf19.2393 Putative transcription factor with zinc finger DNA-binding motif 2394 orf19.2394 Predicted ORF in Assemblies 19, 20 and 21 2397 orf19.2397 Predicted membrane transporter, member of the anion:cation symporter (ACS) family, major facilitator superfamily (MFS); amphotericin B, caspofungin repressed 2397.3 orf19.2397.3 ORF Predicted by Annotation Working Group 2398 orf19.2398 Predicted ORF in Assemblies 19, 20 and 21; possible increased transcription in an azole-resistant strain that overexpresses CDR1 and CDR2; possibly transcriptionally regulated by Tac1p; induced by Mnl1p under weak acid stress 2399 orf19.2399 Putative transcription factor with zinc finger DNA-binding motif; similar to bacterial DnaJ; transcriptionally regulated by iron; expression greater in low iron 240 orf19.240 Predicted ORF in Assemblies 19, 20 and 21 2400 orf19.2400 Predicted ORF in Assemblies 19, 20 and 21 2401 orf19.2401 Predicted ORF in Assemblies 19, 20 and 21 2404 orf19.2404 Predicted ORF in Assemblies 19, 20 and 21 2406 orf19.2406 Predicted ORF in Assemblies 19, 20 and 21 2408 orf19.2408 Predicted ORF in Assemblies 19, 20 and 21 241 orf19.241 Predicted ORF from Assembly 19; removed from Assembly 20 2411 orf19.2411 Predicted ORF in Assemblies 19, 20 and 21 2412 orf19.2412 Predicted ORF in Assemblies 19, 20 and 21 2413 orf19.2413 Predicted ORF from Assembly 19; removed from Assembly 20 2414 orf19.2414 Predicted ORF in Assemblies 19, 20 and 21 2415 orf19.2415 Predicted ORF in Assemblies 19, 20 and 21 2418 orf19.2418 Predicted ORF in Assemblies 19, 20 and 21 2419 orf19.2419 Predicted ORF in Assemblies 19, 20 and 21 242.2 orf19.242.2 ORF Predicted by Annotation Working Group 2423 orf19.2423 Putative DNA-binding transcription factor; has zinc cluster domain; transposon mutation affects filamentous growth 2425.2 orf19.2425.2 Putative ribosomal protein; Plc1p-regulated; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage; merged with orf19.2864.1 in Assembly 20 2426 orf19.2426 Predicted ORF in Assemblies 19, 20 and 21 2428.2 orf19.2428.2 ORF Predicted by Annotation Working Group; removed from Assembly 20 2429 orf19.2429 Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium 2430 orf19.2430 Predicted ORF in Assemblies 19, 20 and 21 2431 orf19.2431 Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium 2433 orf19.2433 Predicted ORF in Assemblies 19, 20 and 21 2436 orf19.2436 Predicted ORF in Assemblies 19, 20 and 21 2438 orf19.2438 Predicted ORF in Assemblies 19, 20 and 21 2439 orf19.2439 Predicted ORF in Assemblies 19, 20 and 21; shows colony morphology-related gene regulation by Ssn6p 2439.1 orf19.2439.1 ORF Predicted by Annotation Working Group 2440 orf19.2440 Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium 2441 orf19.2441 Predicted ORF from Assembly 19; merged with orf19.2440 in Assembly 20 2442 orf19.2442 Decreased transcription is observed in an azole-resistant strain that overexpresses MDR1 2445 orf19.2445 Putative dicarboxylic amino acid permease; fungal-specific (no human or murine homolog); transcription is induced in response to alpha pheromone in SpiderM medium 2446 orf19.2446 Predicted ORF in Assemblies 19, 20 and 21 2447 orf19.2447 Predicted ORF in Assemblies 19, 20 and 21; decreased expression observed in an ssr1 homozygous null mutant 2449 orf19.2449 Predicted ORF in Assemblies 19, 20 and 21; macrophage-induced gene 2452 orf19.2452 Transcriptionally regulated by iron; expression greater in high iron; downregulated in core caspofungin response; ketoconazole-repressed; shows colony morphology-related gene regulation by Ssn6p; possibly subject to Kex2p processing 2455 orf19.2455 Predicted ORF in Assemblies 19, 20 and 21 2456 orf19.2456 Predicted ORF from Assembly 19; merged with orf19.2455 in Assembly 20 2457 orf19.2457 Predicted ORF in Assemblies 19, 20 and 21 2458 orf19.2458 Putative transcription factor with zinc finger DNA-binding motif 2459 orf19.2459 Predicted ORF in Assemblies 19, 20 and 21 246 orf19.246 Predicted ORF in Assemblies 19, 20 and 21; fungal-specific (no human or murine homolog) 2460 orf19.2460 Predicted ORF in Assemblies 19, 20 and 21; exogenously expressed protein is a substrate for Kex2p processing in vitro; transcription is repressed in response to alpha pheromone in SpiderM medium 2468 orf19.2468 Predicted ORF in Assemblies 19, 20 and 21 247 orf19.247 Predicted ORF in Assemblies 19, 20 and 21 2472 orf19.2472 Predicted ORF in Assemblies 19, 20 and 21 2472.1 orf19.2472.1 ORF added to Assembly 21 based on comparative genome analysis 2473 orf19.2473 Decreased transcription is observed upon fluphenazine treatment or in an azole-resistant strain that overexpresses CDR1 and CDR2 2476 orf19.2476 Predicted ORF in Assemblies 19, 20 and 21 2478 orf19.2478 Predicted ORF in Assemblies 19, 20 and 21 2478.1 orf19.2478.1 ORF Predicted by Annotation Working Group 2481 orf19.2481 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 2484 orf19.2484 Predicted ORF in Assemblies 19, 20 and 21 2485 orf19.2485 Predicted ORF in Assemblies 19, 20 and 21 2487 orf19.2487 Predicted ORF in Assemblies 19, 20 and 21 2489 orf19.2489 Predicted ORF in Assemblies 19, 20 and 21; repressed by nitric oxide 2494 orf19.2494 Predicted ORF in Assemblies 19, 20 and 21 2496 orf19.2496 Predicted ORF in Assemblies 19, 20 and 21; fluconazole-downregulated 2498 orf19.2498 Predicted ORF in Assemblies 19, 20 and 21; oxidative stress-induced via Cap1p 2499 orf19.2499 Predicted ORF in Assemblies 19, 20 and 21 25 orf19.25 Predicted ORF in Assemblies 19, 20 and 21 2500 orf19.2500 Predicted ORF in Assemblies 19, 20 and 21 2503 orf19.2503 Predicted ORF in Assemblies 19, 20 and 21 2505 orf19.2505 Predicted ORF in Assemblies 19, 20 and 21 2506 orf19.2506 Predicted ORF in Assemblies 19, 20 and 21; opaque-specific transcription; Hog1p-downregulated 2509 orf19.2509 Predicted ORF in Assemblies 19, 20 and 21 2509.1 orf19.2509.1 ORF added to Assembly 21 based on comparative genome analysis 251 orf19.251 ThiJ/PfpI protein family; antigenic (Cand a 3 allergen); binds human immunoglobulin E; 2 N-glycosylation motifs; alkaline, fluconazole, Hog1p-downregulated; induced in core stress response or by oxidative stress (via Cap1p) 2510 orf19.2510 Predicted ORF in Assemblies 19, 20 and 21 2511 orf19.2511 Predicted ORF from Assembly 19; merged with orf19.2510 in Assembly 20 2511.2 orf19.2511.2 ORF added to Assembly 21 based on comparative genome analysis 2512 orf19.2512 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 2513 orf19.2513 Predicted ORF in Assemblies 19, 20 and 21 2514 orf19.2514 Predicted ORF in Assemblies 19, 20 and 21 2515 orf19.2515 Predicted ORF in Assemblies 19, 20 and 21 2516 orf19.2516 Predicted ORF in Assemblies 19, 20 and 21 2517 orf19.2517 Predicted membrane transporter, member of the drug:proton antiporter (12 spanner) (DHA1) family, major facilitator superfamily (MFS) 2518 orf19.2518 Predicted ORF in Assemblies 19, 20 and 21 2519 orf19.2519 Predicted ORF in Assemblies 19, 20 and 21 252 orf19.252 Predicted ORF in Assemblies 19, 20 and 21 2520 orf19.2520 Predicted ORF in Assemblies 19, 20 and 21 2521 orf19.2521 Predicted ORF in Assemblies 19, 20 and 21 2522 orf19.2522 Predicted ORF from Assembly 19; merged with orf19.2521 in Assembly 20 2527 orf19.2527 Predicted ORF in Assemblies 19, 20 and 21; induced upon biofilm formation 2528 orf19.2528 Predicted ORF in Assemblies 19, 20 and 21; flucytosine repressed 2529 orf19.2529 Predicted ORF in Assemblies 19, 20 and 21; shares similarity with human Pig-H, which is involved in glycosylphosphatidylinositol assembly 2529.1 orf19.2529.1 ORF added to Assembly 21 based on comparative genome analysis 253 orf19.253 Predicted ORF from Assembly 19; merged with orf19.252 in Assembly 20 2530 orf19.2530 Predicted ORF in Assemblies 19, 20 and 21 2533 orf19.2533 Predicted ORF from Assembly 19; merged with orf19.2532 in Assembly 20 2533.1 orf19.2533.1 ORF Predicted by Annotation Working Group 2537 orf19.2537 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 2539 orf19.2539 Predicted ORF in Assemblies 19, 20 and 21 254 orf19.254 Predicted ORF in Assemblies 19, 20 and 21; Hog1p-downregulated 2541 orf19.2541 Predicted ORF in Assemblies 19, 20 and 21 2542 orf19.2542 Predicted ORF in Assemblies 19, 20 and 21 2544 orf19.2544 Predicted ORF in Assemblies 19, 20 and 21 2547 orf19.2547 Predicted ORF in Assemblies 19, 20 and 21 2549 orf19.2549 Predicted ORF in Assemblies 19, 20 and 21 255 orf19.255 Predicted zinc-cluster protein of unknown function; possibly transcriptionally regulated upon hyphal formation; intron in 5'-UTR 2550 orf19.2550 Predicted ORF from Assembly 19; merged with orf19.2549 in Assembly 20 2552 orf19.2552 Protein similar to S. cerevisiae Pmr1p; amphotericin B induced; previously merged with orf19.2553; unmerged from orf19.2553 in a revision of Assembly 21 2553 orf19.2553 Protein similar to S. cerevisiae Pmr1p; amphotericin B induced; previously merged with orf19.2552 in Assembly 20; unmerged from orf19.2552 in a revision of Assembly 21 2558 orf19.2558 Predicted ORF in Assemblies 19, 20 and 21 2563 orf19.2563 Predicted ORF in Assemblies 19, 20 and 21 2564 orf19.2564 Predicted ORF in Assemblies 19, 20 and 21 2565 orf19.2565 Predicted ORF in Assemblies 19, 20 and 21 257 orf19.257 Transcription is negatively regulated by Sfu1p; repressed by nitric oxide 2570 orf19.2570 Predicted ORF in Assemblies 19, 20 and 21 2574 orf19.2574 Predicted ORF in Assemblies 19, 20 and 21 2575 orf19.2575 Predicted ORF in Assemblies 19, 20 and 21 2579 orf19.2579 Predicted ORF in Assemblies 19, 20 and 21 258 orf19.258 Predicted ORF in Assemblies 19, 20 and 21 2581 orf19.2581 Predicted ORF in Assemblies 19, 20 and 21 2582 orf19.2582 Predicted ORF in Assemblies 19, 20 and 21 2583 orf19.2583 Putative oligopeptide transporter 2583.1 orf19.2583.1 Pseudogene; formerly an ORF Predicted by Annotation Working Group 2583.2 orf19.2583.2 Pseudogene; formerly an ORF Predicted by Annotation Working Group 2585 orf19.2585 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 259 orf19.259 Predicted ORF in Assemblies 19, 20 and 21 2590 orf19.2590 Putative protein of unknown function, transcription is upregulated in clinical isolates from HIV+ patients with oral candidiasis; predicted ORF in Assemblies 19, 20 and 21 2591 orf19.2591 Predicted ORF in Assemblies 19, 20 and 21 2594 orf19.2594 Predicted ORF in Assemblies 19, 20 and 21 2595 orf19.2595 Predicted ORF from Assembly 19; merged with orf19.2594 in Assembly 20 2599 orf19.2599 Predicted ORF in Assemblies 19, 20 and 21 26 orf19.26 Predicted ORF in Assemblies 19, 20 and 21; induced by nitric oxide in yhb1 mutant 2604 orf19.2604 Predicted ORF in Assemblies 19, 20 and 21 2605 orf19.2605 Predicted ORF in Assemblies 19, 20 and 21 2607 orf19.2607 Predicted ORF in Assemblies 19, 20 and 21 261 orf19.261 Predicted ORF in Assemblies 19, 20 and 21 2610 orf19.2610 Predicted ORF in Assemblies 19, 20 and 21 2612 orf19.2612 Putative transcription factor with zinc finger DNA-binding motif; decreased expression observed in an ssr1 homozygous null mutant 2620 orf19.2620 Predicted ORF in Assemblies 19, 20 and 21 2621 orf19.2621 Predicted ORF in Assemblies 19, 20 and 21 2624 orf19.2624 Predicted ORF in Assemblies 19, 20 and 21; decreased transcription is observed upon fluphenazine treatment or in an azole-resistant strain that overexpresses CDR1 and CDR2 2625 orf19.2625 Predicted ORF in Assemblies 19, 20 and 21 2629 orf19.2629 Predicted ORF in Assemblies 19, 20 and 21 263 orf19.263 Predicted ORF from Assembly 19; merged with orf19.262 in Assembly 20 263.1 orf19.263.1 Predicted ORF in Assembly 20 and 21; gene has intron 2631 orf19.2631 Predicted ORF in Assemblies 19, 20 and 21 2632 orf19.2632 Predicted ORF from Assembly 19; merged with orf19.3704 in Assembly 20 2633.1 orf19.2633.1 ORF added to Assembly 21 based on comparative genome analysis 2634 orf19.2634 Predicted ORF from Assembly 19; merged with orf19.1988 in Assembly 20 2636 orf19.2636 Predicted ORF from Assembly 19; merged with orf19.6654 in Assembly 20 2637 orf19.2637 Predicted ORF in Assemblies 19, 20 and 21 2638 orf19.2638 Predicted ORF in Assemblies 19, 20 and 21 2639 orf19.2639 Predicted ORF in Assemblies 19, 20 and 21 2639.1 orf19.2639.1 ORF Predicted by Annotation Working Group 264 orf19.264 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 2642 orf19.2642 Predicted ORF in Assemblies 19, 20 and 21 2643 orf19.2643 Putative protein of unknown function; heterozygous null mutant exhibits resistance to parnafungin in the C. albicans fitness test; predicted ORF in Assemblies 19, 20 and 21 2645 orf19.2645 Predicted ORF in Assemblies 19, 20 and 21 2646 orf19.2646 Predicted zinc-finger protein of unknown function, not essential for viability 2647 orf19.2647 Putative transcription factor with zinc cluster DNA-binding motif; caspofungin induced 265 orf19.265 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 2650 orf19.2650 Predicted ORF in Assemblies 19, 20 and 21 2650.1 orf19.2650.1 ORF Predicted by Annotation Working Group 2653 orf19.2653 Protein not essential for viability 2656 orf19.2656 Predicted ORF from Assembly 19; removed from Assembly 20 2657 orf19.2657 Predicted ORF in Assemblies 19, 20 and 21 2658 orf19.2658 Predicted ORF from Assembly 19; merged with orf19.1352 in Assembly 20 2659 orf19.2659 Predicted ORF from Assembly 19; downregulation correlates with clinical development of fluconazole resistance; decreased expression in hyphae compared to yeast-form cells; Ras1p-regulated; merged with orf19.1354 in Assembly 20 2662 orf19.2662 Predicted ORF in Assemblies 19, 20 and 21 2663 orf19.2663 Predicted ORF in Assemblies 19, 20 and 21 2664 orf19.2664 Predicted ORF in Assemblies 19, 20 and 21 2666 orf19.2666 Predicted ORF from Assembly 19; merged with orf19.2665 in Assembly 20 2668.1 orf19.2668.1 Region in retrotransposon Tca4 annotated in Assembly 21 as a blocked reading frame, based on comparative genome analysis; overlaps orf19.2668, which is an open reading frame similar to Gag proteins of retrotransposons 2669 orf19.2669 Predicted ORF in retrotransposon Tca4 with similarity to the Pol region of retrotransposons encoding reverse transcriptase, protease and integrase; downstream from RHD2 with similarity to the Gag region encoding nucleocapsid-like protein 267 orf19.267 Predicted ORF in Assemblies 19, 20 and 21 2670 orf19.2670 Predicted ORF in Assemblies 19, 20 and 21 2671 orf19.2671 Predicted ORF in Assemblies 19, 20 and 21; Plc1p-regulated 2673 orf19.2673 Predicted ORF in Assemblies 19, 20 and 21 2674 orf19.2674 Putative transcription factor with zinc finger DNA-binding motif; possibly spurious ORF (Annotation Working Group prediction) 2675 orf19.2675 Predicted ORF in Assemblies 19, 20 and 21 2676 orf19.2676 Predicted ORF in Assemblies 19, 20 and 21 2677 orf19.2677 Predicted ORF in Assemblies 19, 20 and 21 268 orf19.268 Predicted ORF in Assemblies 19, 20 and 21 2680 orf19.2680 Predicted ORF in Assemblies 19, 20 and 21 2682 orf19.2682 Predicted ORF in Assemblies 19, 20 and 21 2684 orf19.2684 Predicted ORF in Assemblies 19, 20 and 21 2686 orf19.2686 Predicted ORF in Assemblies 19, 20 and 21 2687.1 orf19.2687.1 ORF Predicted by Annotation Working Group 2690 orf19.2690 Predicted ORF in Assemblies 19, 20 and 21 2691 orf19.2691 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 2692 orf19.2692 Predicted ORF from Assembly 19; removed from Assembly 20 2697 orf19.2697 Predicted ORF in Assemblies 19, 20 and 21 2698 orf19.2698 Predicted ORF in Assemblies 19, 20 and 21 27 orf19.27 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 270 orf19.270 Predicted ORF in Assemblies 19, 20 and 21 2701 orf19.2701 Predicted ORF in Assemblies 19, 20 and 21; greater mRNA abundance observed in a cyr1 or ras1 homozygous null mutant than in wild type 2703 orf19.2703 Transcriptionally regulated by iron; expression greater in low iron; increased expression observed in an ssr1 homozygous null mutant; similar to S. cerevisiae Ymr171cp; fungal-specific (no human or murine homolog) 2704 orf19.2704 Predicted ORF in Assemblies 19, 20 and 21 2708 orf19.2708 Predicted ORF in Assemblies 19, 20 and 21; nonessential 2710 orf19.2710 Predicted ORF in Assemblies 19, 20 and 21 2711 orf19.2711 Predicted ORF in Assemblies 19, 20 and 21; downregulated in core stress response 2711.1 orf19.2711.1 ORF Predicted by Annotation Working Group 2713 orf19.2713 Predicted ORF in Assemblies 19, 20 and 21 2714 orf19.2714 Predicted ORF from Assembly 19; merged with orf19.2713 in Assembly 20 2720 orf19.2720 Predicted ORF in Assemblies 19, 20 and 21 2721 orf19.2721 Predicted ORF in Assemblies 19, 20 and 21 2724 orf19.2724 Predicted ORF in Assemblies 19, 20 and 21 2725 orf19.2725 Predicted ORF in Assemblies 19, 20 and 21 2726 orf19.2726 Predicted ORF in Assemblies 19, 20 and 21; Plc1p-regulated 2728 orf19.2728 Predicted ORF in Assemblies 19, 20 and 21 273 orf19.273 Predicted ORF in Assemblies 19, 20 and 21 2730 orf19.2730 Predicted ORF in Assemblies 19, 20 and 21 2731 orf19.2731 Predicted ORF in Assemblies 19, 20 and 21 2732 orf19.2732 Predicted ORF from Assembly 19; merged with orf19.2733 in Assembly 20 2733 orf19.2733 Putative protein of unknown function, transcription is activated in the presence of elevated CO2; predicted ORF in Assemblies 19, 20 and 21 2734 orf19.2734 Protein not essential for viability 2736 orf19.2736 Predicted ORF in Assemblies 19, 20 and 21; flucytosine induced 2737 orf19.2737 Predicted ORF in Assemblies 19, 20 and 21 2739 orf19.2739 Predicted ORF in Assemblies 19, 20 and 21 2740 orf19.2740 Predicted ORF in Assemblies 19, 20 and 21 2742 orf19.2742 Predicted ORF in Assemblies 19, 20 and 21 2743 orf19.2743 Predicted ORF in Assemblies 19, 20 and 21 2745 orf19.2745 Putative transcription factor with zinc cluster DNA-binding motif; similar to S. cerevisiae Ume6p, which is a transcription factor involved in the regulation of meiotic genes 2746 orf19.2746 Predicted ORF in Assemblies 19, 20 and 21 2748 orf19.2748 Predicted zinc-finger protein of unknown function; clade-associated gene expression; similarity to S. cerevisiae Arg81p, which is a transcription factor involved in the regulation of arginine-responsive genes 2749 orf19.2749 Predicted ORF in Assemblies 19, 20 and 21; transcriptionally activated by Mnl1p under weak acid stress 275 orf19.275 Predicted ORF in Assemblies 19, 20 and 21 2751 orf19.2751 Predicted membrane transporter, member of the monocarboxylate porter (MCP) family, major facilitator superfamily (MFS); alkaline upregulated by Rim101p 2753 orf19.2753 Predicted zinc-finger protein of unknown function 2754 orf19.2754 Predicted ORF in Assemblies 19, 20 and 21 2755 orf19.2755 Predicted ORF in Assemblies 19, 20 and 21 2756 orf19.2756 Predicted ORF in Assemblies 19, 20 and 21 2757 orf19.2757 Predicted ORF in Assemblies 19, 20 and 21 2759 orf19.2759 Putative GPI-anchored protein of unknown function; repressed during cell wall regeneration; merged with orf19.2758 in Assembly 20 276 orf19.276 Predicted ORF in Assemblies 19, 20 and 21; increased transcription is observed in an azole-resistant strain that overexpresses MDR1 2760 orf19.2760 Putative protein of unknown function; heterozygous null mutant exhibits hypersensitivity to parnafungin and cordycepin in the C. albicans fitness test; predicted ORF in Assemblies 19, 20 and 21 2761 orf19.2761 Predicted ORF in Assemblies 19, 20 and 21; induced by nitric oxide in yhb1 mutant; possibly spurious ORF (Annotation Working Group prediction) 2763 orf19.2763 Protein not essential for viability; orf19.10279 possibly transcriptionally regulated upon hyphal formation 2766 orf19.2766 Predicted ORF in Assemblies 19, 20 and 21 2769 orf19.2769 Predicted ORF in Assemblies 19, 20 and 21; hyphal-induced expression; greater mRNA abundance observed in a cyr1 or ras1 homozygous null mutant than in wild type 2770 orf19.2770 Predicted ORF in Assemblies 19, 20 and 21 2777 orf19.2777 Predicted ORF from Assembly 19; removed from Assembly 20 2778 orf19.2778 Putative protein of unknown function, transcription is upregulated in clinical isolates from HIV+ patients with oral candidiasis; predicted ORF in Assemblies 19, 20 and 21 2779 orf19.2779 Predicted ORF in Assemblies 19, 20 and 21 278 orf19.278 Predicted ORF in Assemblies 19, 20 and 21 2780 orf19.2780 Predicted ORF from Assembly 19; merged with orf19.2779 in Assembly 20 2781 orf19.2781 Predicted ORF in Assemblies 19, 20 and 21 2782 orf19.2782 Predicted ORF in Assemblies 19, 20 and 21 2784 orf19.2784 Predicted ORF in Assemblies 19, 20 and 21 2786 orf19.2786 Predicted ORF in Assemblies 19, 20 and 21 2788 orf19.2788 Predicted ORF in Assemblies 19, 20 and 21 2789 orf19.2789 Predicted ORF in Assemblies 19, 20 and 21 279 orf19.279 Predicted ORF in Assemblies 19, 20 and 21 2791 orf19.2791 Predicted ORF in Assemblies 19, 20 and 21 2794 orf19.2794 Protein regulated by Gcn4p; repressed in response to amino acid starvation (3-aminotriazole treatment); alkaline upregulated; macrophage-induced protein 2795 orf19.2795 Predicted ORF in Assemblies 19, 20 and 21 2796 orf19.2796 Predicted ORF in Assemblies 19, 20 and 21 2797 orf19.2797 Predicted ORF in Assemblies 19, 20 and 21 2798 orf19.2798 Putative helicase; fungal-specific (no human or murine homolog) 28 orf19.28 Predicted ORF in Assemblies 19, 20 and 21 280 orf19.280 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 2800 orf19.2800 Predicted ORF in Assembly 20 and 21 2801 orf19.2801 Predicted ORF from Assembly 19; removed from Assembly 20 2804 orf19.2804 Predicted ORF in Assemblies 19, 20 and 21 2805 orf19.2805 Predicted ORF in Assemblies 19, 20 and 21; expression regulated during planktonic growth 2806 orf19.2806 Predicted ORF from Assembly 19; expression regulated during planktonic growth; merged with orf19.2805 in Assembly 20 2808 orf19.2808 Predicted zinc-finger protein of unknown function, not essential for viability 281 orf19.281 Predicted ORF in Assemblies 19, 20 and 21 2812 orf19.2812 Predicted ORF in Assemblies 19, 20 and 21 2813 orf19.2813 Predicted ORF in Assemblies 19, 20 and 21 2814 orf19.2814 Predicted ORF from Assembly 19; removed from Assembly 20 2815 orf19.2815 Predicted ORF from Assembly 19; merged with orf19.163 in Assembly 20 2818 orf19.2818 Predicted ORF in Assemblies 19, 20 and 21 2819 orf19.2819 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 2820 orf19.2820 Predicted ORF in Assemblies 19, 20 and 21 2821 orf19.2821 Predicted ORF in Assemblies 19, 20 and 21; repressed by nitric oxide 2822 orf19.2822 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 2824 orf19.2824 Predicted ORF from Assembly 19; merged with orf19.2823 in Assembly 20 2825 orf19.2825 Predicted ORF in Assemblies 19, 20 and 21; a-specific transcription 2826 orf19.2826 Predicted ORF in Assemblies 19, 20 and 21 2827 orf19.2827 Predicted ORF in Assemblies 19, 20 and 21 2828 orf19.2828 Predicted ORF in Assemblies 19, 20 and 21 2829 orf19.2829 Predicted ORF in Assemblies 19, 20 and 21 2835 orf19.2835 Predicted ORF in Assemblies 19, 20 and 21 2836 orf19.2836 Predicted ORF in Assemblies 19, 20 and 21 2838 orf19.2838 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to amphotericin B 284 orf19.284 Predicted ORF in Assemblies 19, 20 and 21 2840 orf19.2840 Predicted ORF from Assembly 19; removed from Assembly 20 2844 orf19.2844 Predicted ORF in Assemblies 19, 20 and 21; induced in core caspofungin response 2846 orf19.2846 Predicted ORF in Assemblies 19, 20 and 21; induced in core caspofungin response; transcription regulated upon yeast-hyphal switch 2847 orf19.2847 Predicted ORF in Assemblies 19, 20 and 21 2847.1 orf19.2847.1 Pseudogene; formerly an ORF Predicted by Annotation Working Group that was subsequently removed from Assembly 20 2848 orf19.2848 Predicted ORF in Assemblies 19, 20 and 21 285 orf19.285 Predicted ORF in Assemblies 19, 20 and 21 2850 orf19.2850 Predicted ORF in Assemblies 19, 20 and 21; induced by nitric oxide in yhb1 mutant 2851 orf19.2851 Predicted ORF in Assemblies 19, 20 and 21 2852 orf19.2852 Predicted ORF in Assemblies 19, 20 and 21 2853 orf19.2853 Predicted ORF in Assemblies 19, 20 and 21 2857 orf19.2857 Predicted ORF in Assemblies 19, 20 and 21 286 orf19.286 Decreased transcription is observed upon fluphenazine treatment; possibly spurious ORF (Annotation Working Group prediction) 2863 orf19.2863 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 2863.1 orf19.2863.1 ORF Predicted by Annotation Working Group 2864 orf19.2864 Predicted ORF from Assembly 19; merged with orf19.2426 in Assembly 20 2865 orf19.2865 Predicted ORF from Assembly 19; merged with orf19.2425 in Assembly 20 2866 orf19.2866 Predicted ORF in Assemblies 19, 20 and 21 2867 orf19.2867 Predicted ORF in Assemblies 19, 20 and 21 2868 orf19.2868 Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium 2869 orf19.2869 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 287 orf19.287 Predicted ORF in Assemblies 19, 20 and 21; repressed by nitric oxide; identified in detergent-resistant membrane fraction (possible lipid raft component) 2870 orf19.2870 Predicted ORF in Assemblies 19, 20 and 21 2875 orf19.2875 Predicted ORF in Assemblies 19, 20 and 21 288 orf19.288 Predicted ORF in Assemblies 19, 20 and 21 2888 orf19.2888 Predicted ORF in Assemblies 19, 20 and 21 2889 orf19.2889 Predicted ORF in Assemblies 19, 20 and 21 2890 orf19.2890 Predicted ORF in Assemblies 19, 20 and 21 2891 orf19.2891 Predicted ORF in Assemblies 19, 20 and 21 2892 orf19.2892 Predicted ORF in Assemblies 19, 20 and 21 2893 orf19.2893 Putative protein of unknown function, regulation correlates with clinical development of fluconazole resistance; transcription is upregulated in an RHE model of oral candidiasis; predicted ORF in Assemblies 19, 20 and 21 2894 orf19.2894 Predicted ORF from Assembly 19; removed from Assembly 20 2898 orf19.2898 Predicted ORF in Assemblies 19, 20 and 21 2899 orf19.2899 Predicted ORF in Assemblies 19, 20 and 21 29 orf19.29 Predicted ORF in Assemblies 19, 20 and 21 2903 orf19.2903 Putative Argonaute protein involved in RNA silencing, member of the Argonaute family; predicted ORF in Assemblies 19, 20 and 21; hyphal-induced expression, regulated by Cyr1p, Ras1p, Efg1p, Nrg1p, Tup1p 2904 orf19.2904 Predicted ORF from Assembly 19; orf19.2903 and orf19.2904 are a single reading frame (see Locus History); hyphal-induced expression, regulated by Cyr1p, Ras1p, Efg1p, Nrg1p, Tup1p; merged with orf19.2903 in Assembly 20 2905 orf19.2905 Predicted ORF in Assemblies 19, 20 and 21 2907.1 orf19.2907.1 ORF Predicted by Annotation Working Group 2908 orf19.2908 Predicted ORF in Assemblies 19, 20 and 21 291 orf19.291 Predicted ORF in Assemblies 19, 20 and 21 2913 orf19.2913 Predicted ORF from Assembly 19; merged with orf19.2911 in Assembly 20 2914 orf19.2914 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 2915 orf19.2915 Predicted ORF in Assemblies 19, 20 and 21 2916 orf19.2916 Predicted ORF in Assemblies 19, 20 and 21 2917 orf19.2917 Putative protein of unknown function; heterozygous null mutant exhibits resistance to parnafungin in the C. albicans fitness test; predicted ORF in Assemblies 19, 20 and 21 2917.1 orf19.2917.1 ORF added to Assembly 21 based on comparative genome analysis 292 orf19.292 Predicted ORF in Assemblies 19, 20 and 21 2920 orf19.2920 Predicted ORF in Assemblies 19, 20 and 21 2921 orf19.2921 Predicted ORF in Assemblies 19, 20 and 21 2922 orf19.2922 Predicted ORF in Assemblies 19, 20 and 21 2923 orf19.2923 Predicted membrane transporter, member of the drug:proton antiporter (14 spanner) (DHA2) family, major facilitator superfamily (MFS); transcription is induced in response to alpha pheromone in SpiderM medium 2924 orf19.2924 Predicted ORF from Assembly 19; merged with orf19.4715 in Assembly 20 2925 orf19.2925 Predicted ORF in Assemblies 19, 20 and 21 (see Locus History Note for Assembly 19 correction) 2926 orf19.2926 Predicted ORF in Assemblies 19, 20 and 21 2928 orf19.2928 Predicted ORF in Assemblies 19, 20 and 21 2930 orf19.2930 Predicted ORF in Assemblies 19, 20 and 21 2933 orf19.2933 Predicted ORF in Assemblies 19, 20 and 21 2934 orf19.2934 Predicted ORF in Assemblies 19, 20 and 21 2936 orf19.2936 Predicted ORF in Assemblies 19, 20 and 21 2938 orf19.2938 Protein not essential for viability 2939 orf19.2939 Predicted ORF in Assemblies 19, 20 and 21 2940 orf19.2940 Predicted ORF in Assemblies 19, 20 and 21 2943 orf19.2943 Predicted ORF from Assembly 19; merged with orf19.2942 in Assembly 20 2943.5 orf19.2943.5 ORF Predicted by Annotation Working Group 2949 orf19.2949 Predicted ORF in Assemblies 19, 20 and 21 295 orf19.295 Predicted ORF in Assemblies 19, 20 and 21 2953 orf19.2953 Predicted ORF in Assemblies 19, 20 and 21 2954 orf19.2954 Predicted ORF in Assemblies 19, 20 and 21; repressed by nitric oxide; possibly spurious ORF (Annotation Working Group prediction) 2957 orf19.2957 Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium 2958 orf19.2958 Predicted ORF in Assemblies 19, 20 and 21 2959 orf19.2959 Predicted ORF from Assembly 19; removed from Assembly 20; subsequently reinstated in Assembly 21 based on comparative genome analysis 2959.1 orf19.2959.1 ORF Predicted by Annotation Working Group 296 orf19.296 Predicted ORF in Assemblies 19, 20 and 21 2961 orf19.2961 Putative transcription factor with zinc finger DNA-binding motif 2962 orf19.2962 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 2963 orf19.2963 Predicted ORF in Assemblies 19, 20 and 21 2964 orf19.2964 Predicted ORF in Assemblies 19, 20 and 21 2965 orf19.2965 Predicted ORF in Assemblies 19, 20 and 21 2965.1 orf19.2965.1 Predicted ORF in Assembly 20 and 21; similar to human SERF2; gene has intron 2966 orf19.2966 Predicted ORF in Assemblies 19, 20 and 21; clade-associated gene expression; farnesol-downregulated 2968 orf19.2968 Predicted ORF in Assemblies 19, 20 and 21 2971 orf19.2971 Predicted ORF in Assemblies 19, 20 and 21 2973 orf19.2973 Predicted ORF in Assemblies 19, 20 and 21 2977 orf19.2977 Predicted ORF in Assemblies 19, 20 and 21 2978 orf19.2978 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 298 orf19.298 ORF Predicted by Annotation Working Group 2980 orf19.2980 Predicted ORF in Assemblies 19, 20 and 21 2982 orf19.2982 Predicted ORF in Assemblies 19, 20 and 21 2984 orf19.2984 Predicted ORF in Assemblies 19, 20 and 21 2985 orf19.2985 Predicted ORF in Assemblies 19, 20 and 21 2986 orf19.2986 Predicted ORF in Assemblies 19, 20 and 21 2987 orf19.2987 Predicted ORF in Assemblies 19, 20 and 21; fungal-specific (no human or murine homolog) 2988 orf19.2988 Predicted ORF in Assemblies 19, 20 and 21 2989 orf19.2989 Predicted ORF in Assemblies 19, 20 and 21 2995 orf19.2995 Predicted ORF in Assemblies 19, 20 and 21; induced by nitric oxide 2996 orf19.2996 Predicted ORF in Assemblies 19, 20 and 21 30 orf19.30 Predicted ORF in Assemblies 19, 20 and 21 3003 orf19.3003 Predicted ORF in Assemblies 19, 20 and 21 3004 orf19.3004 Predicted ORF in Assemblies 19, 20 and 21 3006 orf19.3006 Predicted ORF in Assemblies 19, 20 and 21 3007 orf19.3007 Predicted ORF in Assemblies 19, 20 and 21 3007.2 orf19.3007.2 ORF Predicted by Annotation Working Group 3009 orf19.3009 Protein not essential for viability 3010 orf19.3010 Predicted ORF in Assemblies 19, 20 and 21 3011 orf19.3011 Predicted ORF from Assembly 19; removed from Assembly 20 3016 orf19.3016 Predicted ORF in Assemblies 19, 20 and 21 3019 orf19.3019 Transcription may be increased in an azole-resistant strain that overexpresses MDR1 302 orf19.302 Predicted ORF in Assemblies 19, 20 and 21 3021 orf19.3021 Predicted ORF in Assemblies 19, 20 and 21; induced during planktonic growth 3022 orf19.3022 Predicted ORF in Assemblies 19, 20 and 21 3023 orf19.3023 Predicted ORF in Assemblies 19, 20 and 21 3027 orf19.3027 Predicted ORF in Assemblies 19, 20 and 21 3029 orf19.3029 Predicted ORF in Assemblies 19, 20 and 21 3030 orf19.3030 Predicted ORF in Assemblies 19, 20 and 21 3031 orf19.3031 Predicted ORF in Assemblies 19, 20 and 21 3035 orf19.3035 Predicted ORF in Assemblies 19, 20 and 21 3037 orf19.3037 Protein described as poly(A)-binding protein; regulated by Gcn4p; induced in response to amino acid starvation (3-aminotriazole treatment); rotein detected by mass spec in exponential and stationary phase cultures 304 orf19.304 Putative transporter similar to MDR proteins; fungal-specific (no human or murine homolog) 3041 orf19.3041 Predicted ORF in Assemblies 19, 20 and 21 3042 orf19.3042 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 3043 orf19.3043 Predicted ORF in Assemblies 19, 20 and 21 3045 orf19.3045 Predicted ORF in Assemblies 19, 20 and 21; virulence-group-correlated expression 3046 orf19.3046 Predicted ORF from Assembly 19; removed from Assembly 20 3047 orf19.3047 Predicted ORF in Assemblies 19, 20 and 21 3048 orf19.3048 Predicted ORF in Assemblies 19, 20 and 21; transcription is repressed in response to alpha pheromone in SpiderM medium 3049 orf19.3049 Predicted ORF in Assemblies 19, 20 and 21 305 orf19.305 Predicted ORF in Assemblies 19, 20 and 21; greater mRNA abundance observed in a cyr1 homozygous null mutant than in wild type 3051 orf19.3051 Predicted ORF in Assemblies 19, 20 and 21; shows colony morphology-related gene regulation by Ssn6p 3053 orf19.3053 Predicted ORF in Assemblies 19, 20 and 21; identified in extracts from biofilm and planktonic cells; protein detected by mass spec in exponential and stationary phase cultures 3055 orf19.3055 Predicted ORF in Assemblies 19, 20 and 21 3057 orf19.3057 Predicted ORF in Assemblies 19, 20 and 21 3058 orf19.3058 Predicted ORF in Assemblies 19, 20 and 21 3059.1 orf19.3059.1 ORF added to Assembly 21 based on comparative genome analysis; overlaps orf19.3059.2, which is annotated as a blocked reading frame 3059.2 orf19.3059.2 Region annotated in Assembly 21 as a blocked reading frame, based on comparative genome analysis; overlaps orf19.3059.1, which is an open reading frame 3060 orf19.3060 Predicted ORF in Assemblies 19, 20 and 21 3061 orf19.3061 Predicted ORF in Assemblies 19, 20 and 21 3061.1 orf19.3061.1 Predicted ORF in Assembly 20 and 21; gene has intron; similar to RPS22A/orf19.6265 3062 orf19.3062 Predicted ORF in Assemblies 19, 20 and 21 3063 orf19.3063 Phosphorylated protein of unknown function; predicted ORF in Assemblies 19, 20 and 21 3064.1 orf19.3064.1 ORF added to Assembly 21 based on comparative genome analysis 3067 orf19.3067 Predicted ORF from Assembly 19; merged with orf19.5377 in Assembly 20 3068 orf19.3068 Predicted ORF from Assembly 19; merged with orf19.5376 in Assembly 20 307 orf19.307 Predicted ORF in Assemblies 19, 20 and 21 3070.1 orf19.3070.1 ORF Predicted by Annotation Working Group; merged with orf19.1288 in Assembly 20 3073 orf19.3073 Predicted ORF in Assemblies 19, 20 and 21 3076 orf19.3076 Predicted ORF in Assemblies 19, 20 and 21 3079 orf19.3079 Predicted ORF from Assembly 19; removed from Assembly 20 308 orf19.308 Predicted ORF in Assemblies 19, 20 and 21 3080 orf19.3080 Predicted ORF in Assemblies 19, 20 and 21 3083 orf19.3083 Predicted ORF in Assemblies 19, 20 and 21 3084 orf19.3084 Predicted ORF in Assemblies 19, 20 and 21 3086 orf19.3086 Predicted ORF in Assemblies 19, 20 and 21 3087.1 orf19.3087.1 ORF added to Assembly 21 based on comparative genome analysis 3087.2 orf19.3087.2 ORF added to Assembly 21 based on comparative genome analysis 3088 orf19.3088 Putative transcription factor with bZIP DNA-binding motif; induced upon biofilm formation; possibly transcriptionally regulated upon hyphal formation 3089 orf19.3089 Predicted ORF in Assemblies 19, 20 and 21 3090 orf19.3090 Predicted ORF from Assembly 19; merged with orf19.3091 in Assembly 20 3091 orf19.3091 Predicted ORF in Assemblies 19, 20 and 21; downregulated during core stress response 3096 orf19.3096 Predicted ORF from Assembly 19; merged with orf19.3097 in Assembly 20 3098 orf19.3098 Predicted ORF in Assemblies 19, 20 and 21 31 orf19.31 Predicted ORF in Assemblies 19, 20 and 21 310 orf19.310 Predicted ORF in Assemblies 19, 20 and 21 3100 orf19.3100 Predicted ORF in Assemblies 19, 20 and 21; transcription is repressed in response to alpha pheromone in SpiderM medium 3103 orf19.3103 Predicted ORF in Assemblies 19, 20 and 21 3105 orf19.3105 Predicted ORF in Assemblies 19, 20 and 21 3107 orf19.3107 Predicted ORF in Assemblies 19, 20 and 21 3108 orf19.3108 Predicted ORF in Assemblies 19, 20 and 21; induced by nitric oxide in yhb1 mutant 3109 orf19.3109 Predicted ORF in Assemblies 19, 20 and 21 311 orf19.311 Predicted ORF from Assembly 19; removed from Assembly 20 3110 orf19.3110 Predicted ORF in Assemblies 19, 20 and 21 3113 orf19.3113 Predicted ORF in Assemblies 19, 20 and 21 3114 orf19.3114 Predicted ORF in Assemblies 19, 20 and 21 3115 orf19.3115 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 3118 orf19.3118 Predicted ORF from Assembly 19; removed from Assembly 20 3119 orf19.3119 Predicted ORF from Assembly 19; merged with orf19.3117 in Assembly 20 312 orf19.312 Predicted ORF from Assembly 19; merged with orf19.310 in Assembly 20 3120 orf19.3120 Putative PDR-subfamily ABC transporter (half-size); similar to WHITE subfamily proteins; decreased transcription is observed upon fluphenazine treatment or in an azole-resistant strain that overexpresses CDR1 and CDR2; induced by nitric oxide 3122.2 orf19.3122.2 ORF Predicted by Annotation Working Group 3123.2 orf19.3123.2 ORF Predicted by Annotation Working Group 3124 orf19.3124 Predicted ORF in Assemblies 19, 20 and 21 3125 orf19.3125 Protein not essential for viability 3128 orf19.3128 Predicted ORF in Assemblies 19, 20 and 21 3129 orf19.3129 Predicted ORF in Assemblies 19, 20 and 21; heterozygous null mutant displays sensitivity to virgineone 3130 orf19.3130 Predicted ORF in Assemblies 19, 20 and 21 3132 orf19.3132 Predicted ORF in Assemblies 19, 20 and 21; induced by nitric oxide 3134 orf19.3134 Predicted ORF in Assemblies 19, 20 and 21 3135 orf19.3135 Predicted ORF in Assemblies 19, 20 and 21 3136 orf19.3136 Predicted ORF in Assemblies 19, 20 and 21 3139 orf19.3139 Predicted ORF in Assemblies 19, 20 and 21; increased transcription is observed upon benomyl treatment; oxidative stress-induced via Cap1p 314 orf19.314 Predicted ORF in Assemblies 19, 20 and 21 3140 orf19.3140 Predicted ORF in Assemblies 19, 20 and 21 3140.1 orf19.3140.1 ORF Predicted by Annotation Working Group 3141 orf19.3141 Predicted ORF in Assemblies 19, 20 and 21 3142 orf19.3142 Predicted ORF in Assemblies 19, 20 and 21 3143 orf19.3143 Predicted ORF from Assembly 19; merged with orf19.2866 in Assembly 20 3144 orf19.3144 Predicted ORF from Assembly 19; removed from Assembly 20 3145 orf19.3145 Predicted ORF from Assembly 19; removed from Assembly 20 3145.4 orf19.3145.4 ORF Predicted by Annotation Working Group; removed from Assembly 20 3146 orf19.3146 Predicted ORF from Assembly 19; merged with orf19.2227 in Assembly 20 3147 orf19.3147 Predicted ORF in Assemblies 19, 20 and 21 3148 orf19.3148 Predicted ORF in Assemblies 19, 20 and 21 315 orf19.315 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 3151 orf19.3151 Predicted ORF in Assemblies 19, 20 and 21 3154 orf19.3154 Predicted ORF in Assemblies 19, 20 and 21 3156 orf19.3156 Predicted ORF in Assemblies 19, 20 and 21; transcriptionally activated by Mnl1p under weak acid stress 3158 orf19.3158 Predicted ORF in Assemblies 19, 20 and 21 3159.4 orf19.3159.4 ORF Predicted by Annotation Working Group 3161 orf19.3161 Predicted ORF in Assemblies 19, 20 and 21 3163 orf19.3163 Predicted ORF in Assemblies 19, 20 and 21 3166 orf19.3166 Predicted ORF in Assemblies 19, 20 and 21 3167 orf19.3167 Predicted ORF in Assemblies 19, 20 and 21 3169 orf19.3169 Predicted ORF in Assemblies 19, 20 and 21 317 orf19.317 Predicted ORF in Assemblies 19, 20 and 21 3170 orf19.3170 Predicted ORF in Assemblies 19, 20 and 21 3172 orf19.3172 Predicted ORF in Assemblies 19, 20 and 21 3173 orf19.3173 Predicted ORF in Assemblies 19, 20 and 21 3175 orf19.3175 Predicted ORF in Assemblies 19, 20 and 21; alkaline downregulated; repressed by nitric oxide; virulence-group-correlated expression 3177 orf19.3177 Predicted ORF in Assemblies 19, 20 and 21 3178 orf19.3178 Predicted ORF in Assemblies 19, 20 and 21 318 orf19.318 Predicted ORF in Assemblies 19, 20 and 21 3180 orf19.3180 Predicted ORF in Assemblies 19, 20 and 21 3181.1 orf19.3181.1 ORF Predicted by Annotation Working Group 3183 orf19.3183 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 3184 orf19.3184 Predicted ORF in Assemblies 19, 20 and 21 3185 orf19.3185 Predicted ORF in Assemblies 19, 20 and 21 3186 orf19.3186 Predicted ORF in Assemblies 19, 20 and 21 3189 orf19.3189 Predicted ORF from Assembly 19; merged with orf19.3188 in Assembly 20 319 orf19.319 Predicted ORF in Assemblies 19, 20 and 21 3191 orf19.3191 Predicted ORF from Assembly 19; merged with orf19.3192 in Assembly 20; protein detected by mass spec in exponential and stationary phase cultures 3196 orf19.3196 Predicted ORF in Assemblies 19, 20 and 21 32 orf19.32 Predicted ORF from Assembly 19; removed from Assembly 20 320 orf19.320 Predicted ORF in Assemblies 19, 20 and 21 3202 orf19.3202 Protein not essential for viability 3204 orf19.3204 Predicted ORF in Assemblies 19, 20 and 21 3205 orf19.3205 Predicted ORF in Assemblies 19, 20 and 21 321 orf19.321 Predicted ORF in Assemblies 19, 20 and 21 3210 orf19.3210 Predicted ORF in Assemblies 19, 20 and 21; Plc1p-regulated; possibly spurious ORF (Annotation Working Group prediction) 3213 orf19.3213 Predicted ORF in Assemblies 19, 20 and 21 3214 orf19.3214 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 3215 orf19.3215 Predicted ORF in Assemblies 19, 20 and 21; transcription is repressed in response to alpha pheromone in SpiderM medium 3216 orf19.3216 Similar to Rab GTPase activators 3218 orf19.3218 Putative multidrug resistance protein; upregulated by Efg1p 3219 orf19.3219 Predicted ORF in Assemblies 19, 20 and 21 322 orf19.322 Predicted ORF in Assemblies 19, 20 and 21 3220 orf19.3220 Predicted ORF in Assemblies 19, 20 and 21 3222 orf19.3222 Predicted ORF in Assemblies 19, 20 and 21; fungal-specific (no human or murine homolog) 3223.1 orf19.3223.1 Predicted ORF; described as 12kDa subunit of mitochondrial NADH-ubiquinone oxidoreductase; gene has intron 3224 orf19.3224 Predicted ORF from Assembly 19; merged with orf19.3223 in Assembly 20 3226 orf19.3226 Predicted ORF in Assemblies 19, 20 and 21 3228 orf19.3228 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to amphotericin B 3229 orf19.3229 Predicted ORF in Assemblies 19, 20 and 21 323 orf19.323 Predicted ORF in Assemblies 19, 20 and 21 3232 orf19.3232 Putative transporter; mutation confers hypersensitivity to toxic ergosterol analog; fungal-specific (no human or murine homolog) 3233 orf19.3233 Predicted ORF in Assemblies 19, 20 and 21 3235 orf19.3235 Predicted ORF in Assemblies 19, 20 and 21 3237 orf19.3237 Predicted ORF in Assemblies 19, 20 and 21 3238 orf19.3238 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 3241 orf19.3241 Predicted ORF in Assemblies 19, 20 and 21 3242 orf19.3242 Predicted ORF in Assemblies 19, 20 and 21 3244 orf19.3244 Predicted ORF in Assemblies 19, 20 and 21 3245 orf19.3245 Predicted ORF in Assemblies 19, 20 and 21 3246 orf19.3246 Predicted ORF from Assembly 19; merged with orf19.3245 in Assembly 20 3247 orf19.3247 Predicted ORF in Assemblies 19, 20 and 21; putative ortholog of S. cerevisiae Yjl207cp; likely to be essential for growth, based on an insertional mutagenesis strategy 3248 orf19.3248 Predicted ORF in Assemblies 19, 20 and 21 325 orf19.325 Putative protein of unknown function; heterozygous null mutant exhibits hypersensitivity to parnafungin and cordycepin in the C. albicans fitness test; predicted ORF in Assemblies 19, 20 and 21 3250 orf19.3250 Predicted ORF in Assemblies 19, 20 and 21 3252 orf19.3252 Predicted zinc-finger protein of unknown function; has similarity to S. cerevisiae Dal81p, which is a transcription factor involved in the regulation of nitrogen-degradation genes 3254 orf19.3254 Protein not essential for viability; possibly spurious ORF (Annotation Working Group prediction) 3255 orf19.3255 Transcription is regulated upon yeast-hyphal switch; possibly spurious ORF (Annotation Working Group prediction) 3259 orf19.3259 Predicted ORF in Assemblies 19, 20 and 21 326 orf19.326 Predicted ORF in Assemblies 19, 20 and 21 3260 orf19.3260 Predicted ORF in Assemblies 19, 20 and 21 3261 orf19.3261 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 3262 orf19.3262 Predicted ORF from Assembly 19; removed from Assembly 20 3263 orf19.3263 Predicted ORF in Assemblies 19, 20 and 21 3264.1 orf19.3264.1 ORF added to Assembly 21 based on comparative genome analysis 3265.1 orf19.3265.1 ORF added to Assembly 21 based on comparative genome analysis 3266 orf19.3266 Predicted ORF in Assemblies 19, 20 and 21 3267 orf19.3267 Predicted ORF in Assemblies 19, 20 and 21 3268 orf19.3268 Ortholog of S. cerevisiae Tma19p (Ykl065cp) 3270 orf19.3270 Predicted ORF from Assembly 19; merged with orf19.3269 in Assembly 20 3271 orf19.3271 ORF Predicted by Annotation Working Group; possibly spurious ORF (Annotation Working Group prediction) 3272 orf19.3272 Predicted ORF in Assemblies 19, 20 and 21 3273 orf19.3273 Predicted ORF in Assemblies 19, 20 and 21 3274 orf19.3274 Predicted ORF from Assembly 19; merged with orf19.3273 in Assembly 20 3275 orf19.3275 Predicted ORF in Assemblies 19, 20 and 21 3277 orf19.3277 Predicted ORF in Assemblies 19, 20 and 21 3280 orf19.3280 ORF Predicted by Annotation Working Group 3281 orf19.3281 Predicted ORF in Assemblies 19, 20 and 21 3283 orf19.3283 Predicted ORF in Assemblies 19, 20 and 21 3284 orf19.3284 ORF Predicted by Annotation Working Group 3285 orf19.3285 Predicted ORF in Assemblies 19, 20 and 21 3286 orf19.3286 Predicted ORF in Assemblies 19, 20 and 21 3288.1 orf19.3288.1 Predicted ORF in Assembly 20 and 21; merged with orf19.3288 in Assembly 21 3289 orf19.3289 Phosphorylated protein of unknown function; predicted ORF in Assemblies 19, 20 and 21 329 orf19.329 Predicted ORF in Assemblies 19, 20 and 21 3290 orf19.3290 Predicted ORF in Assemblies 19, 20 and 21; repressed by nitric oxide 3292 orf19.3292 Predicted ORF in Assemblies 19, 20 and 21 3293 orf19.3293 Predicted ORF in Assemblies 19, 20 and 21 3295 orf19.3295 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 3296 orf19.3296 Predicted ORF in Assemblies 19, 20 and 21 3297 orf19.3297 Predicted ORF in Assemblies 19, 20 and 21 33 orf19.33 Predicted ORF from Assembly 19; removed from Assembly 20 330.1 orf19.330.1 ORF Predicted by Annotation Working Group 3301 orf19.3301 Predicted ORF in Assemblies 19, 20 and 21; induced by heavy metal (cadmium) stress; Hog1p-induced; transcriptionally activated by Mnl1p under weak acid stress 3302 orf19.3302 Predicted ORF in Assemblies 19, 20 and 21; transcription downregulated upon yeast-hyphal switch; transcriptionally activated by Mnl1p under weak acid stress 3303 orf19.3303 Predicted ORF in Assemblies 19, 20 and 21 3304 orf19.3304 Predicted ORF in Assemblies 19, 20 and 21 3305 orf19.3305 Putative transcription factor with zinc cluster DNA-binding motif 3306 orf19.3306 Predicted ORF in Assemblies 19, 20 and 21 3307 orf19.3307 Predicted ORF in Assemblies 19, 20 and 21 3308 orf19.3308 Putative transcription factor with zinc cluster DNA-binding motif; has similarity to S. cerevisiae Stb5p 3309 orf19.3309 Predicted ORF in Assemblies 19, 20 and 21 331 orf19.331 Predicted ORF in Assemblies 19, 20 and 21 3310 orf19.3310 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 3312 orf19.3312 Predicted ORF in Assemblies 19, 20 and 21 3314 orf19.3314 Predicted ORF in Assemblies 19, 20 and 21 3317 orf19.3317 Predicted ORF in Assemblies 19, 20 and 21 3318 orf19.3318 Predicted ORF in Assemblies 19, 20 and 21 3319 orf19.3319 Predicted ORF in Assemblies 19, 20 and 21 332 orf19.332 Predicted ORF in Assemblies 19, 20 and 21 332.1 orf19.332.1 ORF added to Assembly 21 based on comparative genome analysis 3320 orf19.3320 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 3321 orf19.3321 Predicted ORF in Assemblies 19, 20 and 21 3323 orf19.3323 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 3325 orf19.3325 Protein described as glycogen synthesis initiator; regulated by Efg1p and Efh1p; Hog1p-downregulated; shows colony morphology-related gene regulation by Ssn6p; increased expression in response to prostaglandins 3328 orf19.3328 Predicted ORF in Assemblies 19, 20 and 21; filament induced 3329 orf19.3329 Predicted ORF in Assemblies 19, 20 and 21 3332 orf19.3332 Predicted ORF in Assemblies 19, 20 and 21 3333 orf19.3333 Predicted ORF in Assemblies 19, 20 and 21 3335 orf19.3335 Predicted ORF in Assemblies 19, 20 and 21; shows colony morphology-related gene regulation by Ssn6p; repressed by nitric oxide 3336 orf19.3336 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 3337 orf19.3337 Predicted ORF in Assemblies 19, 20 and 21 3338 orf19.3338 Predicted ORF in Assemblies 19, 20 and 21 3339 orf19.3339 Predicted ORF from Assembly 19; removed from Assembly 20 334 orf19.334 Predicted ORF in Assemblies 19, 20 and 21 3341 orf19.3341 Putative tRNA-Arg synthetase; essential; S. cerevisiae ortholog is essential; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage 3342 orf19.3342 Predicted ORF in Assemblies 19, 20 and 21 3348 orf19.3348 Predicted ORF in Assemblies 19, 20 and 21 3349 orf19.3349 Putative protein of unknown function; heterozygous null mutant exhibits resistance to parnafungin in the C. albicans fitness test; predicted ORF in Assemblies 19, 20 and 21 335 orf19.335 Predicted ORF in Assemblies 19, 20 and 21 3351 orf19.3351 Predicted ORF in Assemblies 19, 20 and 21 3352 orf19.3352 Predicted ORF in Assemblies 19, 20 and 21 3353 orf19.3353 Protein described as similar to a mitochondrial complex I intermediate-associated protein; fluconazole-downregulated 3354 orf19.3354 Predicted ORF in Assemblies 19, 20 and 21 3357 orf19.3357 Predicted ORF in Assemblies 19, 20 and 21 3360 orf19.3360 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 3361 orf19.3361 Predicted ORF from Assembly 19; merged with orf19.4551 in Assembly 20 3362 orf19.3362 Predicted ORF in Assemblies 19, 20 and 21 3364 orf19.3364 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 3366.1 orf19.3366.1 ORF Predicted by Annotation Working Group 3367 orf19.3367 Predicted ORF in Assemblies 19, 20 and 21 3368 orf19.3368 Predicted ORF in Assemblies 19, 20 and 21 337 orf19.337 Predicted ORF in Assemblies 19, 20 and 21 3371 orf19.3371 Predicted ORF in Assemblies 19, 20 and 21 3372 orf19.3372 Predicted ORF from Assembly 19; merged with orf19.3371 in Assembly 20 3373 orf19.3373 Putative protein of unknown function, transcription is upregulated in clinical isolates from HIV+ patients with oral candidiasis; predicted ORF in Assemblies 19, 20 and 21 3375 orf19.3375 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 3376 orf19.3376 Predicted ORF in Assemblies 19, 20 and 21 3378 orf19.3378 Predicted ORF in Assemblies 19, 20 and 21; regulated by Tsa1p, Tsa1Bp in minimal media at 37 deg 338 orf19.338 Predicted ORF in Assemblies 19, 20 and 21; Hog1p-downregulated; shows colony morphology-related gene regulation by Ssn6p; protein detected by mass spec in stationary phase cultures 3384 orf19.3384 Putative cell wall protein with C-terminal similarity to Hwp1p; alkaline upregulated; alpha factor induced; Rim101p-regulated; merged with orf19.1327 in Assembly 20 3385 orf19.3385 Predicted ORF from Assembly 19; removed from Assembly 20 3386 orf19.3386 ORF Predicted by Annotation Working Group; removed from Assembly 20 3387 orf19.3387 Predicted ORF from Assembly 19; clade-associated gene expression; removed from Assembly 20 3388 orf19.3388 Predicted ORF from Assembly 19; removed from Assembly 20 3390 orf19.3390 Putative transcription factor with zinc finger DNA-binding motif; merged with orf19.684 in Assembly 20 3393 orf19.3393 Putative DEAD-box helicase 3394 orf19.3394 Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium 3395 orf19.3395 Predicted membrane transporter, member of the drug:proton antiporter (12 spanner) (DHA1) family, major facilitator superfamily (MFS); induced by nitric oxide, oxidative stress, alpha pheromone; fungal-specific (no human or murine homolog) 3399 orf19.3399 Predicted ORF in Assemblies 19, 20 and 21 34 orf19.34 Putative permease of glycerophosphoinositol import; fungal-specific (no human or murine homolog); transcription is negatively regulated by Rim101p; virulence-group-correlated expression 340 orf19.340 Predicted ORF in Assemblies 19, 20 and 21 3404 orf19.3404 Decreased transcription is observed upon fluphenazine treatment 3405 orf19.3405 Putative transcription factor with zinc finger DNA-binding motif; heterozygous null mutant displays sensitivity to virgineone; possibly spurious ORF (Annotation Working Group prediction) 3406 orf19.3406 Predicted ORF in Assemblies 19, 20 and 21; member of conserved Mcm1p regulon 3407 orf19.3407 Putative transcription factor with zinc finger DNA-binding motif 341 orf19.341 Putative spermidine export pump; fungal-specific (no human or murine homolog) 3411 orf19.3411 Predicted ORF in Assemblies 19, 20 and 21 3418 orf19.3418 Predicted ORF in Assemblies 19, 20 and 21 3420 orf19.3420 Predicted ORF in Assemblies 19, 20 and 21; decreased expression in hyphae compared to yeast-form cells 3421.1 orf19.3421.1 ORF Predicted by Annotation Working Group 3425 orf19.3425 Predicted ORF in Assemblies 19, 20 and 21 3427 orf19.3427 Predicted ORF in Assemblies 19, 20 and 21 3428 orf19.3428 Predicted ORF in Assemblies 19, 20 and 21 3430 orf19.3430 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction); physically interacts with TAP-tagged Nop1p 3431 orf19.3431 Predicted ORF in Assemblies 19, 20 and 21 3432 orf19.3432 Predicted membrane transporter, member of the drug:proton antiporter (12 spanner) (DHA1) family, major facilitator superfamily (MFS); induced by nitric oxide 3434 orf19.3434 Predicted ORF in Assemblies 19, 20 and 21 3435 orf19.3435 Predicted ORF in Assemblies 19, 20 and 21 3436 orf19.3436 Predicted ORF in Assemblies 19, 20 and 21; macrophage-induced gene 3437 orf19.3437 Predicted ORF in Assemblies 19, 20 and 21 3438 orf19.3438 Predicted ORF in Assemblies 19, 20 and 21 3439 orf19.3439 Predicted ORF in Assemblies 19, 20 and 21; greater mRNA abundance observed in a cyr1 homozygous null mutant than in wild type 344 orf19.344 ############################################################################################################################################################################################################################################################### 3442 orf19.3442 Predicted ORF in Assemblies 19, 20 and 21 3444 orf19.3444 Predicted membrane transporter, member of the drug:proton antiporter (14 spanner) (DHA2) family, major facilitator superfamily (MFS) 3446 orf19.3446 Predicted ORF in Assemblies 19, 20 and 21 3447 orf19.3447 Predicted ORF in Assemblies 19, 20 and 21 3448 orf19.3448 Predicted ORF in Assemblies 19, 20 and 21; ketoconazole-repressed; possibly spurious ORF (Annotation Working Group prediction) 3449 orf19.3449 Predicted ORF in Assemblies 19, 20 and 21 3449.2 orf19.3449.2 ORF Predicted by Annotation Working Group 345 orf19.345 Predicted ORF in Assemblies 19, 20 and 21 3450 orf19.3450 Predicted ORF from Assembly 19; merged with orf19.3450.1 in Assembly 20 3450.1 orf19.3450.1 Predicted ORF in Assemblies 19, 20 and 21 3451 orf19.3451 Predicted ORF from Assembly 19; merged with orf19.139 in Assembly 20 3453 orf19.3453 Predicted ORF in Assemblies 19, 20 and 21 3455 orf19.3455 Predicted ORF in Assemblies 19, 20 and 21 3456 orf19.3456 Predicted ORF in Assemblies 19, 20 and 21 3458 orf19.3458 Predicted ORF in Assemblies 19, 20 and 21 3459 orf19.3459 Predicted ORF in Assemblies 19, 20 and 21 346 orf19.346 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to 5-fluorocytosine (5-FC) 3460 orf19.3460 Transcription is regulated upon yeast-hyphal switch 3461 orf19.3461 Predicted ORF in Assemblies 19, 20 and 21; oxidative stress-induced via Cap1p; transcription is induced in response to alpha pheromone in SpiderM medium 3463 orf19.3463 Predicted ORF in Assemblies 19, 20 and 21 3466 orf19.3466 Predicted ORF in Assemblies 19, 20 and 21; decreased transcription is observed upon fluphenazine treatment or in an azole-resistant strain that overexpresses CDR1 and CDR2 3467 orf19.3467 Predicted ORF in Assemblies 19, 20 and 21 3469 orf19.3469 Predicted ORF in Assemblies 19, 20 and 21; greater mRNA abundance observed in a cyr1 homozygous null mutant than in wild type 3470 orf19.3470 Putative flavodoxin; similar to S. cerevisiae Ypl207p; predicted Kex2p substrate 3471 orf19.3471 Predicted ORF in Assemblies 19, 20 and 21 3473 orf19.3473 Predicted ORF in Assemblies 19, 20 and 21 3475 orf19.3475 Described as a Gag-related protein; hyphal induced; downregulation correlates with clinical development of fluconazole resistance; repressed by nitric oxide, 17-beta-estradiol, ethynyl estradiol 3476 orf19.3476 Predicted ORF in Assemblies 19, 20 and 21 3477 orf19.3477 Predicted ORF in Assemblies 19, 20 and 21 3479 orf19.3479 Predicted ORF in Assemblies 19, 20 and 21 3480 orf19.3480 Predicted ORF in Assemblies 19, 20 and 21 3481 orf19.3481 Putative protein of unknown function, transcription is activated in the presence of elevated CO2; predicted ORF in Assemblies 19, 20 and 21 3482 orf19.3482 Predicted ORF in Assemblies 19, 20 and 21 3483 orf19.3483 Predicted ORF in Assemblies 19, 20 and 21; Plc1p-regulated 3484 orf19.3484 Predicted ORF from Assembly 19; merged with orf19.6284 in Assembly 20 3485 orf19.3485 Predicted ORF from Assembly 19; merged with orf19.6283 in Assembly 20 3486 orf19.3486 Predicted ORF from Assembly 19; merged with orf19.6282 in Assembly 20 3487 orf19.3487 Predicted ORF in Assemblies 19, 20 and 21 3488 orf19.3488 Predicted ORF from Assembly 19; merged with orf19.1985 in Assembly 20 349 orf19.349 Predicted ORF in Assemblies 19, 20 and 21 3491 orf19.3491 Predicted ORF from Assembly 19; merged with orf19.1135 in Assembly 20 3492 orf19.3492 Predicted ORF from Assembly 19; removed from Assembly 20 3493 orf19.3493 Predicted ORF from Assembly 19; removed from Assembly 20 3496 orf19.3496 Predicted ORF in Assemblies 19, 20 and 21 3498 orf19.3498 Predicted ORF in Assemblies 19, 20 and 21; predicted enzyme of arginine degradation 3499 orf19.3499 Predicted ORF in Assemblies 19, 20 and 21; regulated by Tsa1p, Tsa1Bp under H2O2 stress conditions; transcriptionally activated by Mnl1p under weak acid stress 35 orf19.35 Predicted ORF in Assemblies 19, 20 and 21 35.1 orf19.35.1 ORF added to Assembly 21 based on comparative genome analysis 3501 orf19.3501 Predicted ORF in Assemblies 19, 20 and 21; Hog1p-downregulated 3503 orf19.3503 Predicted ORF in Assemblies 19, 20 and 21 3505 orf19.3505 Predicted ORF in Assemblies 19, 20 and 21 3508 orf19.3508 Predicted ORF in Assemblies 19, 20 and 21; protein detected by mass spec in stationary phase cultures 3509 orf19.3509 Predicted ORF from Assembly 19; merged with orf19.692 in Assembly 20 351 orf19.351 Predicted ORF in Assemblies 19, 20 and 21 3510 orf19.3510 Predicted ORF in Assemblies 19 and 20; identical to orf19.5284; merged with orf19.5284 in Assembly 20 (see Locus History) 3512 orf19.3512 Predicted ORF in Assemblies 19, 20 and 21 3515 orf19.3515 Putative 3-hydroxyanthranilic acid dioxygenase, involved in NAD biosynthesis 3516 orf19.3516 Predicted ORF in Assemblies 19, 20 and 21 3517 orf19.3517 Predicted ORF in Assemblies 19, 20 and 21 3518 orf19.3518 Predicted ORF in Assemblies 19, 20 and 21 352 orf19.352 Predicted ORF in Assemblies 19, 20 and 21 3520 orf19.3520 Predicted ORF from Assembly 19; merged with orf19.5852 in Assembly 20 3522 orf19.3522 Predicted ORF in Assemblies 19, 20 and 21; transcription is downregulated in response to treatment with ciclopirox olamine 3524 orf19.3524 Protein kinase of the Cdc2 subfamily involved in hyphal development and virulence; promotes hyphal development independently of Cph1 and Efg1; complements S. cerevisiae sgv1 mutant; merged with orf19.3523 in Assembly 20 3528 orf19.3528 Predicted ORF in Assemblies 19, 20 and 21 3531 orf19.3531 Predicted ORF in Assemblies 19, 20 and 21 3533 orf19.3533 Predicted ORF in Assemblies 19, 20 and 21 3535 orf19.3535 Predicted ORF in Assemblies 19, 20 and 21 3536 orf19.3536 Predicted ORF in Assemblies 19, 20 and 21 3537 orf19.3537 Predicted ORF in Assemblies 19, 20 and 21; regulated by Tsa1p, Tsa1Bp in minimal media at 37 deg 3539 orf19.3539 Predicted ORF in Assemblies 19, 20 and 21 354 orf19.354 Predicted ORF in Assemblies 19, 20 and 21 3543 orf19.3543 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 3544 orf19.3544 Predicted ORF in Assemblies 19, 20 and 21 3545 orf19.3545 Predicted ORF in Assemblies 19, 20 and 21 3546 orf19.3546 Predicted ORF in Assemblies 19, 20 and 21 3547 orf19.3547 Predicted ORF in Assemblies 19, 20 and 21 3548 orf19.3548 Predicted ORF in Assemblies 19, 20 and 21 355 orf19.355 Predicted ORF in Assemblies 19, 20 and 21 3551 orf19.3551 Predicted ORF in Assemblies 19, 20 and 21 3552 orf19.3552 Predicted ORF in Assemblies 19, 20 and 21 3555 orf19.3555 Predicted ORF in Assemblies 19, 20 and 21 3556 orf19.3556 Predicted ORF in Assemblies 19, 20 and 21 3557 orf19.3557 Predicted ORF in Assemblies 19, 20 and 21 3558 orf19.3558 Predicted ORF in Assemblies 19, 20 and 21 3559 orf19.3559 Predicted ORF in Assemblies 19, 20 and 21 3560 orf19.3560 Predicted ORF from Assembly 19; merged with orf19.3559 in Assembly 20 3563 orf19.3563 Protein not essential for viability 3565 orf19.3565 Predicted ORF in Assemblies 19, 20 and 21 3569 orf19.3569 Predicted ORF in Assemblies 19, 20 and 21; constitutive expression independent of MTL or white-opaque status 357 orf19.357 Predicted ORF in Assemblies 19, 20 and 21 3571 orf19.3571 Predicted ORF in Assemblies 19, 20 and 21 3572 orf19.3572 Predicted ORF in Assemblies 19, 20 and 21 3572.3 orf19.3572.3 ORF Predicted by Annotation Working Group 3573 orf19.3573 Predicted ORF in Assemblies 19, 20 and 21 3574 orf19.3574 Predicted ORF in Assemblies 19, 20 and 21 3577.1 orf19.3577.1 ORF Predicted by Annotation Working Group 3578 orf19.3578 Predicted ORF in Assemblies 19, 20 and 21 3581 orf19.3581 Predicted ORF in Assemblies 19, 20 and 21 3582 orf19.3582 Predicted ORF in Assemblies 19, 20 and 21 3583 orf19.3583 Predicted ORF in Assemblies 19, 20 and 21 3584 orf19.3584 Predicted ORF from Assembly 19; merged with orf19.225 in Assembly 20 3585 orf19.3585 Predicted ORF in Assemblies 19, 20 and 21; regulated by Gcn4p; repressed in response to amino acid starvation (3-aminotriazole treatment) 3586 orf19.3586 Predicted ORF in Assemblies 19, 20 and 21 3588 orf19.3588 Predicted ORF from Assembly 19; merged with orf19.3586 in Assembly 20 3594 orf19.3594 Predicted ORF from Assembly 19; removed from Assembly 20; subsequently reinstated in Assembly 21 based on comparative genome analysis 36 orf19.36 Predicted ORF in Assemblies 19, 20 and 21; clade-associated gene expression 36.1 orf19.36.1 ORF added to Assembly 21 based on comparative genome analysis 3600 orf19.3600 Predicted ORF in Assemblies 19, 20 and 21 3601 orf19.3601 Predicted ORF in Assemblies 19, 20 and 21 3603 orf19.3603 Predicted ORF in Assemblies 19, 20 and 21 3604 orf19.3604 Predicted ORF in Assemblies 19, 20 and 21 3605 orf19.3605 Predicted ORF in Assemblies 19, 20 and 21 3606 orf19.3606 Predicted ORF in Assemblies 19, 20 and 21; transcriptionally activated by Mnl1p under weak acid stress 3607 orf19.3607 Predicted ORF in Assemblies 19, 20 and 21 3608 orf19.3608 Predicted ORF in Assemblies 19, 20 and 21 361 orf19.361 Predicted ORF from Assembly 19; merged with orf19.4551 in Assembly 20 3610 orf19.3610 Predicted ORF in Assemblies 19, 20 and 21; upregulation correlates with clinical development of fluconazole resistance 3611 orf19.3611 Predicted ORF in Assemblies 19, 20 and 21; repressed by nitric oxide 3613 orf19.3613 Predicted ORF in Assemblies 19, 20 and 21 3615 orf19.3615 Predicted ORF in Assemblies 19, 20 and 21; induced in core caspofungin response; increased expression observed in an ssr1 homozygous null mutant; induced by nitric oxide in yhb1 mutant 3617 orf19.3617 Putative protein of unknown function, transcription is upregulated in clinical isolates from HIV+ patients with oral candidiasis;; predicted ORF in Assemblies 19, 20 and 21 (see Locus History Note for Assembly 19 correction) 3621 orf19.3621 Possible pseudogene; similar to Ywp1p; ORF extended upstream from the initiating Met of orf19.3621 has a stop codon in the region corresponding to the Ywp1p signal peptide; disruption causes no apparent phenotype; no expression detected 3624 orf19.3624 Predicted ORF in Assemblies 19, 20 and 21 3625 orf19.3625 Predicted ORF in Assemblies 19, 20 and 21 3626 orf19.3626 Predicted ORF in Assemblies 19, 20 and 21 3626.1 orf19.3626.1 ORF added to Assembly 21 based on comparative genome analysis 3627 orf19.3627 Predicted ORF in Assemblies 19, 20 and 21 3631 orf19.3631 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 3633 orf19.3633 Predicted ORF in Assemblies 19, 20 and 21 3635 orf19.3635 Predicted ORF in Assemblies 19, 20 and 21 3637 orf19.3637 Predicted ORF in Assemblies 19, 20 and 21 3639 orf19.3639 Predicted ORF in Assemblies 19, 20 and 21 364 orf19.364 Predicted ORF in Assemblies 19, 20 and 21 3640 orf19.3640 Predicted ORF from Assembly 19; removed from Assembly 20 3641 orf19.3641 Expression is regulated upon white-opaque switching; merged with orf19.84 in Assembly 20 3643 orf19.3643 Predicted ORF in Assemblies 19, 20 and 21 3644 orf19.3644 Predicted ORF in Assemblies 19, 20 and 21; greater mRNA abundance observed in a cyr1 homozygous null mutant than in wild type 3647 orf19.3647 Predicted ORF in Assemblies 19, 20 and 21 3648 orf19.3648 Predicted ORF in Assemblies 19, 20 and 21 3649 orf19.3649 Predicted ORF in Assemblies 19, 20 and 21 3655 orf19.3655 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 3658 orf19.3658 Predicted ORF in Assemblies 19, 20 and 21 3659 orf19.3659 Predicted ORF in Assemblies 19, 20 and 21 366 orf19.366 Predicted ORF in Assemblies 19, 20 and 21 3660 orf19.3660 Predicted ORF in Assemblies 19, 20 and 21 3661 orf19.3661 Predicted ORF in Assemblies 19, 20 and 21; transcriptionally activated by Mnl1p under weak acid stress 3663.1 orf19.3663.1 Predicted ORF in Assembly 20 and 21; gene has intron 3665 orf19.3665 Predicted ORF in Assemblies 19, 20 and 21 3666 orf19.3666 Predicted ORF in Assemblies 19, 20 and 21 3667 orf19.3667 Predicted ORF in Assemblies 19, 20 and 21 3671 orf19.3671 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 3673 orf19.3673 Predicted ORF in Assemblies 19, 20 and 21 3677 orf19.3677 Predicted ORF in Assemblies 19, 20 and 21 3678 orf19.3678 Protein not essential for viability 3679 orf19.3679 Predicted ORF in Assemblies 19, 20 and 21; protein detected by mass spec in stationary phase cultures 3681 orf19.3681 Predicted ORF in Assemblies 19, 20 and 21 3683 orf19.3683 Putative transcription factor with zinc finger DNA-binding motif 3684 orf19.3684 Predicted ORF in Assemblies 19, 20 and 21 3686 orf19.3686 Predicted ORF in Assemblies 19, 20 and 21 3687 orf19.3687 Predicted ORF in Assemblies 19, 20 and 21 3688 orf19.3688 Predicted ORF in Assemblies 19, 20 and 21 3689 orf19.3689 Predicted ORF in Assemblies 19, 20 and 21; decreased expression observed in an ssr1 homozygous null mutant 3690 orf19.3690 Predicted ORF from Assembly 19; merged with orf19.3689 in Assembly 20 3690.2 orf19.3690.2 ORF Predicted by Annotation Working Group 3691 orf19.3691 Predicted ORF in Assemblies 19, 20 and 21; ketoconazole-repressed 3694 orf19.3694 Predicted ORF in Assemblies 19, 20 and 21 3695 orf19.3695 Predicted ORF in Assemblies 19, 20 and 21 3697 orf19.3697 Predicted ORF in Assemblies 19, 20 and 21 3698 orf19.3698 Predicted ORF in Assemblies 19, 20 and 21; filament induced 37 orf19.37 Predicted ORF from Assembly 19; removed from Assembly 20 3701 orf19.3701 Protein not essential for viability 3702 orf19.3702 Predicted ORF from Assembly 19; merged with orf19.6452 in Assembly 20 3703 orf19.3703 Predicted ORF from Assembly 19; possibly spurious ORF (Annotation Working Group prediction); merged with orf19.6453 in Assembly 20 3704 orf19.3704 Predicted ORF in Assemblies 19, 20 and 21 3704.1 orf19.3704.1 ORF Predicted by Annotation Working Group 3706 orf19.3706 Predicted ORF in Assemblies 19, 20 and 21 3709 orf19.3709 Predicted ORF from Assembly 19; removed from Assembly 20 371 orf19.371 Predicted ORF in Assemblies 19, 20 and 21 3711 orf19.3711 Predicted ORF in Assemblies 19, 20 and 21 3712 orf19.3712 Predicted ORF in Assemblies 19, 20 and 21; transcriptionally activated by Mnl1p under weak acid stress 3713 orf19.3713 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction); transcriptionally activated by Mnl1p under weak acid stress 3714 orf19.3714 Predicted ORF in Assemblies 19, 20 and 21 3716 orf19.3716 Predicted ORF from Assembly 19; merged with orf19.612 in Assembly 20 3717 orf19.3717 Predicted ORF from Assembly 19; removed from Assembly 20 3718 orf19.3718 Gene fragment (probable assembly 19 error); 5' end of OPT4-2 allele (oligopeptide transporter); fungal-specific (no human or murine homolog); transcriptionally induced upon phagocytosis by macrophage; merged with orf19.176 in Assembly 20 3719 orf19.3719 Predicted ORF in Assemblies 19, 20 and 21 372 orf19.372 Predicted ORF in Assemblies 19, 20 and 21 3720 orf19.3720 Predicted ORF in Assemblies 19, 20 and 21 3721 orf19.3721 Predicted ORF in Assemblies 19, 20 and 21 3722 orf19.3722 Predicted ORF in Assemblies 19, 20 and 21 3724 orf19.3724 Predicted ORF in Assemblies 19, 20 and 21 3726 orf19.3726 Predicted ORF in Assemblies 19, 20 and 21 3728 orf19.3728 Predicted ORF in Assemblies 19, 20 and 21 3730 orf19.3730 Protein similar to S. cerevisiae Kre27p, which has a role in resistance to killer toxin; predicted Kex2p substrate 3735 orf19.3735 Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium 3737 orf19.3737 Predicted ORF in Assemblies 19, 20 and 21; transcription is downregulated in response to treatment with ciclopirox olamine 374 orf19.374 Predicted ORF in Assemblies 19, 20 and 21 3741 orf19.3741 Predicted ORF from Assembly 19; removed from Assembly 20 3742 orf19.3742 Predicted ORF in Assemblies 19, 20 and 21; expression regulated during planktonic growth; greater mRNA abundance observed in a cyr1 homozygous null mutant than in wild type; possibly spurious ORF (Annotation Working Group prediction) 3743 orf19.3743 Predicted ORF in Assemblies 19, 20 and 21 3744 orf19.3744 Predicted ORF in Assemblies 19, 20 and 21 3747 orf19.3747 Predicted ORF from Assembly 19; orf19.3747 and orf19.3748 are short, overlapping ORFs in intergenic region between two oligopeptide transporter-encoding genes; removed from Assembly 20 3748 orf19.3748 ORF Predicted by Annotation Working Group; orf19.3747 and orf19.3748 are short, overlapping ORFs in intergenic region between two oligopeptide transporter-encoding genes 3751 orf19.3751 Predicted ORF in Assemblies 19, 20 and 21 3755 orf19.3755 Predicted ORF in Assemblies 19, 20 and 21 3758 orf19.3758 Predicted ORF in Assemblies 19, 20 and 21 3759 orf19.3759 Predicted ORF in Assemblies 19, 20 and 21 376 orf19.376 Predicted ORF in Assemblies 19, 20 and 21 3762 orf19.3762 Predicted ORF in Assemblies 19, 20 and 21 3763 orf19.3763 Predicted ORF in Assemblies 19, 20 and 21 3767 orf19.3767 Predicted ORF in Assemblies 19, 20 and 21 3768 orf19.3768 Predicted ORF from Assembly 19; merged with orf19.736 in Assembly 20 3769 orf19.3769 Predicted ORF in Assemblies 19, 20 and 21 3771 orf19.3771 Predicted ORF from Assembly 19; merged with orf19.3770 in Assembly 20 3772 orf19.3772 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction); merged with orf19.3773 in Assembly 21 3773 orf19.3773 Putative RNAse III, ortholog of S. cerevisiae RNT1; predicted ORF in Assemblies 19, 20 and 21; merged with orf19.3772 in Assembly 21 3774.1 orf19.3774.1 ORF Predicted by Annotation Working Group 3776 orf19.3776 Predicted ORF from Assembly 19; merged with orf19.3775 in Assembly 20 3777 orf19.3777 Predicted ORF in Assemblies 19, 20 and 21 3778 orf19.3778 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU); downregulated in core stress response; decreased expression in response to prostaglandins 3779 orf19.3779 Predicted ORF from Assembly 19; merged with orf19.3778 in Assembly 20 378 orf19.378 Predicted ORF from Assembly 19; merged with orf19.5633 in Assembly 20 3780 orf19.3780 Protein likely to be essential for growth, based on an insertional mutagenesis strategy 3781 orf19.3781 Predicted ORF in Assemblies 19, 20 and 21 3782 orf19.3782 Predicted membrane transporter, member of the peptide-acetyl-coA transporter (PAT) family, major facilitator superfamily (MFS); transcription is induced in response to alpha pheromone in Spider medium 3782.2 orf19.3782.2 ORF Predicted by Annotation Working Group; intron in 5'-UTR 3783 orf19.3783 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 3784 orf19.3784 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 3785 orf19.3785 Predicted ORF in Assemblies 19, 20 and 21 3787 orf19.3787 Predicted ORF in Assemblies 19, 20 and 21 3788 orf19.3788 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 379 orf19.379 Predicted ORF from Assembly 19; removed from Assembly 20 3790 orf19.3790 Predicted ORF from Assembly 19; repressed by nitric oxide; removed from Assembly 20 3792 orf19.3792 Predicted ORF in Assemblies 19, 20 and 21 3793 orf19.3793 Predicted ORF in Assemblies 19, 20 and 21; regulated by Nrg1p; greater mRNA abundance observed in a cyr1 or ras1 homozygous null mutant than in wild type; possibly spurious ORF (Annotation Working Group prediction) 3796 orf19.3796 Putative Dicer RNAse involved in RNA interference, similar to S. cerevisiae Rnt1p but orthologous to S. castellii Dcr1p, which is not conserved in S. cerevisiae; predicted ORF in Assemblies 19, 20 and 21 3797 orf19.3797 Predicted ORF in Assemblies 19, 20 and 21 3798 orf19.3798 Predicted ORF in Assemblies 19, 20 and 21 3799 orf19.3799 Predicted ORF in Assemblies 19, 20 and 21 38 orf19.38 Predicted ORF from Assembly 19; possibly spurious ORF (Annotation Working Group prediction); removed from Assembly 20 380 orf19.380 Predicted ORF from Assembly 19; merged with orf19.2429 in Assembly 20 3800 orf19.3800 Predicted ORF from Assembly 19; removed from Assembly 20 3804 orf19.3804 Predicted ORF in Assemblies 19, 20 and 21; filament induced 3806 orf19.3806 Predicted ORF in Assemblies 19, 20 and 21 3809 orf19.3809 Putative transcription factor with Myb-like DNA-binding motif; similar to S. cerevisiae Bas1p, which is a regulator of purine biosynthetic genes; ADE genes are not induced during GCN response in C. albicans, in contrast to S. cerevisiae 381 orf19.381 Predicted ORF from Assembly 19; merged with orf19.2661 in Assembly 20 3810 orf19.3810 Predicted ORF in Assemblies 19, 20 and 21 3813 orf19.3813 Predicted ORF in Assemblies 19, 20 and 21 3814 orf19.3814 Predicted ORF from Assembly 19; merged with orf19.3813 in Assembly 20 3815 orf19.3815 Predicted ORF in Assemblies 19, 20 and 21 3817 orf19.3817 Predicted ORF in Assemblies 19, 20 and 21 3819 orf19.3819 Predicted ORF in Assemblies 19, 20 and 21 3820 orf19.3820 Predicted ORF in Assemblies 19, 20 and 21; clade-associated gene expression 3821 orf19.3821 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 3826 orf19.3826 Predicted ORF in Assemblies 19, 20 and 21; Plc1p-regulated 3827 orf19.3827 Predicted ORF in Assemblies 19, 20 and 21 3828 orf19.3828 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 3831 orf19.3831 Predicted ORF in Assemblies 19, 20 and 21 3833 orf19.3833 Putative DNA-binding transcription factor; decreased transcription is observed upon fluphenazine treatment 3835 orf19.3835 Putative DNA-binding transcription factor; merged with orf19.3833 in Assembly 20 3836 orf19.3836 Predicted ORF in Assemblies 19, 20 and 21 384 orf19.384 Predicted ORF in Assemblies 19, 20 and 21 3840 orf19.3840 Predicted ORF in Assemblies 19, 20 and 21 3841 orf19.3841 Predicted ORF in Assemblies 19, 20 and 21; described as similar to S. cerevisiae Apg1p; induced upon adherence to polystyrene 3843 orf19.3843 Predicted ORF in Assemblies 19, 20 and 21 3848 orf19.3848 Predicted ORF in Assemblies 19, 20 and 21 3851 orf19.3851 Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium 3852 orf19.3852 Predicted ORF in Assemblies 19, 20 and 21 3854 orf19.3854 Protein similar to S. cerevisiae Sat4p; amphotericin B induced; clade-associated gene expression 3858 orf19.3858 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 3859 orf19.3859 Predicted ORF in Assemblies 19, 20 and 21; transcription is upregulated in response to treatment with ciclopirox olamine; transcription is induced in response to alpha pheromone in SpiderM medium 3862 orf19.3862 Predicted ORF in Assemblies 19, 20 and 21; heterozygous null mutant displays sensitivity to rapamycin 3863 orf19.3863 Predicted ORF in Assemblies 19, 20 and 21 3868 orf19.3868 Predicted ORF in Assemblies 19, 20 and 21 3869 orf19.3869 Predicted ORF in Assemblies 19, 20 and 21; regulated by Tsa1p, Tsa1Bp in minimal media at 37 deg; shows colony morphology-related gene regulation by Ssn6p 3871 orf19.3871 Predicted ORF in Assemblies 19, 20 and 21 3872 orf19.3872 Predicted ORF in Assemblies 19, 20 and 21 3874 orf19.3874 Predicted ORF in Assemblies 19, 20 and 21 3876 orf19.3876 Predicted zinc-finger protein of unknown function 3877 orf19.3877 Predicted ORF in Assemblies 19, 20 and 21; previously merged with orf19.3878; unmerged from orf19.3878 in a revision of Assembly 21 3878 orf19.3878 Predicted ORF from Assembly 19; merged with orf19.3877 in Assembly 20; unmerged from orf19.3877 in a revision of Assembly 21 3879 orf19.3879 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction); overlaps orf19.3879.1, which is a region annotated as blocked reading frame 3879.1 orf19.3879.1 Region annotated in Assembly 21 as a blocked reading frame, based on comparative genome analysis; overlaps orf19.3879, which is an open reading frame 3881 orf19.3881 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 3885 orf19.3885 Predicted ORF in Assemblies 19, 20 and 21 3886 orf19.3886 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 3887 orf19.3887 Predicted ORF in Assemblies 19, 20 and 21 3888.2 orf19.3888.2 ORF Predicted by Annotation Working Group 3889 orf19.3889 Predicted ORF from Assembly 19; removed from Assembly 20 389 orf19.389 Predicted ORF in Assemblies 19, 20 and 21 3890 orf19.3890 Predicted ORF from Assembly 19; removed from Assembly 20 3894 orf19.3894 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to toxic ergosterol analog 3897 orf19.3897 Predicted ORF in Assemblies 19, 20 and 21; decreased transcription is observed upon fluphenazine treatment or in an azole-resistant strain that overexpresses CDR1 and CDR2; transcription is repressed in response to alpha pheromone in SpiderM medium 3898 orf19.3898 Predicted ORF in Assemblies 19, 20 and 21 39 orf19.39 Predicted ORF from Assembly 19; removed from Assembly 20 3900 orf19.3900 Predicted ORF in Assemblies 19, 20 and 21 3901 orf19.3901 Putative benzene desulfurase; induced by nitric oxide in yhb1 mutant 3902 orf19.3902 Predicted ORF in Assemblies 19, 20 and 21; decreased transcription is observed upon fluphenazine treatment or in an azole-resistant strain that overexpresses CDR1 and CDR2 3903 orf19.3903 Predicted ORF in Assemblies 19, 20 and 21 3904 orf19.3904 Predicted ORF in Assemblies 19, 20 and 21 3905 orf19.3905 Predicted ORF in Assemblies 19, 20 and 21 3906 orf19.3906 Protein not essential for viability 3907 orf19.3907 Predicted ORF in Assemblies 19, 20 and 21 3908 orf19.3908 Predicted ORF in Assemblies 19, 20 and 21 3910 orf19.3910 Predicted ORF in Assemblies 19, 20 and 21 3914 orf19.3914 Predicted ORF in Assemblies 19, 20 and 21 3915 orf19.3915 Predicted ORF in Assemblies 19, 20 and 21; Hog1p-induced; protein detected by mass spec in exponential and stationary phase cultures 3916 orf19.3916 Predicted ORF in Assemblies 19, 20 and 21 3917 orf19.3917 Predicted ORF from Assembly 19; merged with orf19.3916 in Assembly 20 3919 orf19.3919 Predicted ORF in Assemblies 19, 20 and 21 3919.1 orf19.3919.1 ORF added to Assembly 21 based on comparative genome analysis 392 orf19.392 Predicted ORF in Assemblies 19, 20 and 21 3920 orf19.3920 Predicted ORF in Assemblies 19, 20 and 21 3921 orf19.3921 Predicted ORF in Assemblies 19, 20 and 21 3922 orf19.3922 Predicted ORF in Assemblies 19, 20 and 21; protein detected by mass spec in exponential and stationary phase cultures 3924 orf19.3924 Predicted ORF in Assemblies 19, 20 and 21 3925 orf19.3925 Putative protein of unknown function, transcription is activated in the presence of elevated CO2; predicted ORF in Assemblies 19, 20 and 21 3926 orf19.3926 Predicted ORF in Assemblies 19, 20 and 21 3928 orf19.3928 Putative transcription factor with zinc finger DNA-binding motif 3929 orf19.3929 Predicted ORF in Assemblies 19, 20 and 21 393 orf19.393 Predicted ORF in Assemblies 19, 20 and 21 3931.1 orf19.3931.1 Pseudogene; added to Assembly 21 based on comparative genome analysis 3931.2 orf19.3931.2 ORF added to Assembly 21 based on comparative genome analysis 3932 orf19.3932 Predicted ORF in Assemblies 19, 20 and 21; induced in core caspofungin response; increased expression observed in ssr1 homozygous null mutant; induced by nitric oxide in yhb1 mutant; protein detected by mass spec in stationary phase culture 3932.1 orf19.3932.1 ORF added to Assembly 21 based on comparative genome analysis 3935 orf19.3935 Predicted ORF in Assemblies 19, 20 and 21 3936 orf19.3936 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to 5-fluorouracil (5-FU); induced upon biofilm formation 3937 orf19.3937 Predicted ORF in Assemblies 19, 20 and 21 3938 orf19.3938 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine) 3939 orf19.3939 Predicted ORF in Assemblies 19, 20 and 21 394 orf19.394 Putative kynureninase, involved in NAD biosynthesis 3940 orf19.3940 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 3942 orf19.3942 Predicted ORF in Assemblies 19, 20 and 21 3945 orf19.3945 Predicted ORF in Assemblies 19, 20 and 21 3946 orf19.3946 Predicted ORF in Assemblies 19, 20 and 21 3947 orf19.3947 Predicted ORF in Assemblies 19, 20 and 21 3949 orf19.3949 Predicted ORF in Assemblies 19, 20 and 21 3952 orf19.3952 Predicted ORF in Assemblies 19, 20 and 21 3954 orf19.3954 Predicted ORF in Assemblies 19, 20 and 21 3954.1 orf19.3954.1 ORF added to Assembly 21 based on comparative genome analysis 3956 orf19.3956 Predicted ORF in Assemblies 19, 20 and 21 3957 orf19.3957 Predicted ORF in Assemblies 19, 20 and 21 3963 orf19.3963 Predicted ORF in Assemblies 19, 20 and 21 3965 orf19.3965 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 3968 orf19.3968 Predicted ORF in Assemblies 19, 20 and 21 3969 orf19.3969 Predicted ORF in Assemblies 19, 20 and 21 397 orf19.397 Predicted ORF in Assemblies 19, 20 and 21 3970 orf19.3970 Predicted ORF in Assemblies 19, 20 and 21 3971 orf19.3971 Predicted ORF in Assemblies 19, 20 and 21 3972 orf19.3972 Predicted ORF in Assemblies 19, 20 and 21 3973 orf19.3973 Predicted ORF in Assemblies 19, 20 and 21 3975 orf19.3975 Predicted ORF from Assembly 19; removed from Assembly 20 3976 orf19.3976 Predicted ORF in Assemblies 19, 20 and 21 3977 orf19.3977 Predicted ORF in Assemblies 19, 20 and 21 3978 orf19.3978 Predicted ORF in Assemblies 19, 20 and 21 398 orf19.398 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 3980 orf19.3980 Predicted ORF in Assemblies 19, 20 and 21 3982 orf19.3982 Maltase; induced during growth on sucrose; transcription is induced in response to alpha pheromone in SpiderM medium 3983 orf19.3983 Predicted ORF in Assemblies 19, 20 and 21 3984 orf19.3984 Predicted ORF in Assemblies 19, 20 and 21; induced in core caspofungin response; increased expression observed in an ssr1 homozygous null mutant; induced by nitric oxide in yhb1 mutant 3986 orf19.3986 Putative transcription factor with zinc cluster DNA-binding motif; has similarity to S. cerevisiae Ppr1p, which is a transcription factor involved in the regulation of uracil biosynthesis genes 3988 orf19.3988 Predicted ORF in Assemblies 19, 20 and 21; transcriptionally activated by Mnl1p under weak acid stress 399 orf19.399 Predicted ORF in Assemblies 19, 20 and 21 3990 orf19.3990 Predicted ORF in Assemblies 19, 20 and 21 3991 orf19.3991 Predicted ORF in Assemblies 19, 20 and 21 3992 orf19.3992 Predicted ORF from Assembly 19; removed from Assembly 20; subsequently reinstated in Assembly 21 based on comparative genome analysis 3994 orf19.3994 Predicted ORF in Assemblies 19, 20 and 21 3996 orf19.3996 Putative mannosyltransferase; similar to S. cerevisiae Gpi10p; has HKEXRF motif 3998 orf19.3998 Predicted ORF in Assemblies 19, 20 and 21 3999 orf19.3999 Predicted ORF in Assemblies 19, 20 and 21 40 orf19.40 Predicted ORF from Assembly 19; possibly spurious ORF (Annotation Working Group prediction); removed from Assembly 20 4000 orf19.4000 Putative homeodomain transcription factor; predicted ORF in Assemblies 19, 20 and 21 4001 orf19.4001 Predicted ORF in Assemblies 19, 20 and 21 4005 orf19.4005 Protein likely to be essential for growth, based on an insertional mutagenesis strategy 4006 orf19.4006 Predicted ORF in Assemblies 19, 20 and 21 4007 orf19.4007 Predicted ORF in Assemblies 19, 20 and 21 4011 orf19.4011 Predicted ORF in Assemblies 19, 20 and 21 4013 orf19.4013 Predicted ORF in Assemblies 19, 20 and 21 4014 orf19.4014 Predicted ORF in Assemblies 19, 20 and 21; described as similar to S. cerevisiae Cdc1p; induced upon adherence to polystyrene 4016 orf19.4016 Predicted ORF in Assemblies 19, 20 and 21; amphotericin B induced; repressed by nitric oxide; protein level decreased in stationary phase cultures 4017 orf19.4017 Predicted ORF in Assemblies 19, 20 and 21 4018 orf19.4018 Predicted ORF in Assemblies 19, 20 and 21 4019 orf19.4019 Predicted ORF in Assemblies 19, 20 and 21 4021 orf19.4021 Predicted ORF in Assemblies 19, 20 and 21 4028 orf19.4028 Predicted ORF in Assemblies 19, 20 and 21 4029 orf19.4029 Predicted ORF in Assemblies 19, 20 and 21 4030 orf19.4030 Predicted ORF in Assemblies 19, 20 and 21 4031 orf19.4031 Predicted ORF in Assemblies 19, 20 and 21 4034 orf19.4034 Predicted ORF from Assembly 19; merged with orf19.4032 in Assembly 20 4042 orf19.4042 Predicted ORF from Assembly 19; removed from Assembly 20 4043 orf19.4043 Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium 4046 orf19.4046 Putative transcription factor containing a Zn(2)-Cys(6) binuclear cluster; predicted ORF in Assemblies 19, 20 and 21 4055 orf19.4055 Protein similar to S. cerevisiae Ybr075wp; transposon mutation affects filamentous growth; clade-associated gene expression 4057 orf19.4057 Predicted ORF in Assemblies 19, 20 and 21 4059 orf19.4059 Predicted ORF in Assemblies 19, 20 and 21 4061 orf19.4061 Predicted ORF in Assemblies 19, 20 and 21; clade-associated gene expression 4062 orf19.4062 Predicted ORF in Assemblies 19, 20 and 21 4065 orf19.4065 Predicted ORF from Assembly 19; removed from Assembly 20 4066 orf19.4066 Predicted ORF in Assemblies 19, 20 and 21; Hog1p-downregulated 4068 orf19.4068 Predicted ORF in Assemblies 19, 20 and 21 4069 orf19.4069 Predicted ORF in Assemblies 19, 20 and 21; transcription is repressed in response to alpha pheromone in SpiderM medium 4070 orf19.4070 Predicted ORF in Assemblies 19, 20 and 21 4078 orf19.4078 Predicted ORF in Assemblies 19, 20 and 21 408 orf19.408 Predicted ORF from Assembly 19; removed from Assembly 20 4080 orf19.4080 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 4081 orf19.4081 Predicted ORF in Assemblies 19, 20 and 21 4085 orf19.4085 Predicted ORF in Assemblies 19, 20 and 21 4086 orf19.4086 Predicted ORF in Assemblies 19, 20 and 21 4088 orf19.4088 Predicted ORF in Assemblies 19, 20 and 21 409 orf19.409 Predicted membrane protein; similar to S. cerevisiae Ynr018Wp 4090 orf19.4090 Predicted membrane transporter, member of the fucose:proton symporter (FHS) family, major facilitator superfamily (MFS) 4090.1 orf19.4090.1 ORF Predicted by Annotation Working Group 4091 orf19.4091 Predicted ORF in Assemblies 19, 20 and 21 4092 orf19.4092 Predicted ORF in Assemblies 19, 20 and 21; decreased transcription is observed upon fluphenazine treatment or in an azole-resistant strain that overexpresses CDR1 and CDR2 4094 orf19.4094 Predicted ORF in Assemblies 19, 20 and 21 4095 orf19.4095 Predicted ORF in Assemblies 19, 20 and 21 4096 orf19.4096 Predicted ORF in Assemblies 19, 20 and 21 4097 orf19.4097 Predicted ORF in Assemblies 19, 20 and 21 410 orf19.410 Predicted ORF from Assembly 19; removed from Assembly 20 410.3 orf19.410.3 Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase); catalyzes the penultimate step in the synthesis of riboflavin 4100 orf19.4100 Predicted ORF from Assembly 19; merged with orf19.564 in Assembly 20 4101 orf19.4101 Predicted ORF in Assemblies 19, 20 and 21 4104 orf19.4104 Predicted ORF in Assemblies 19, 20 and 21 4105 orf19.4105 Predicted ORF in Assemblies 19, 20 and 21 4106 orf19.4106 Predicted ORF in Assemblies 19, 20 and 21 4107 orf19.4107 Predicted ORF in Assemblies 19, 20 and 21 411 orf19.411 Protein described as similar to GTPase regulators; possibly spurious ORF (Annotation Working Group prediction); transcriptionally regulated by iron; expression greater in low iron; transcriptionally activated by Mnl1p under weak acid stress 4110 orf19.4110 Predicted ORF in Assemblies 19, 20 and 21 4112 orf19.4112 Predicted ORF in Assemblies 19, 20 and 21 4115 orf19.4115 Predicted ORF in Assemblies 19, 20 and 21 4116 orf19.4116 Protein not essential for viability 4117 orf19.4117 Protein not essential for viability 412 orf19.412 Predicted ORF in Assemblies 19, 20 and 21 4121 orf19.4121 Predicted ORF in Assemblies 19, 20 and 21 4122 orf19.4122 Predicted ORF in Assemblies 19, 20 and 21 4123 orf19.4123 Predicted ORF in Assemblies 19, 20 and 21 4125 orf19.4125 Putative transcription factor with zinc finger DNA-binding motif 4127 orf19.4127 Predicted ORF in Assemblies 19, 20 and 21 4128 orf19.4128 Predicted ORF in Assemblies 19, 20 and 21 4129 orf19.4129 Predicted ORF from Assembly 19; merged with orf19.1926 in Assembly 20 413 orf19.413 Transcription is positively regulated by Sfu1p 4131 orf19.4131 Predicted ORF in Assemblies 19, 20 and 21 4132 orf19.4132 Predicted ORF in Assemblies 19, 20 and 21 4133 orf19.4133 Predicted ORF in Assemblies 19, 20 and 21 4134 orf19.4134 Predicted ORF in Assemblies 19, 20 and 21 4138 orf19.4138 Predicted ORF from Assembly 19; merged with orf19.4136 in Assembly 20 4139 orf19.4139 Protein not essential for viability; merged with orf19.4136 in Assembly 20 414 orf19.414 Predicted ORF in Assemblies 19, 20 and 21 4141 orf19.4141 Predicted ORF from Assembly 19; merged with orf19.4142 in Assembly 20 4142 orf19.4142 Predicted ORF in Assemblies 19, 20 and 21; decreased transcription is observed upon fluphenazine treatment 4143 orf19.4143 Predicted ORF in Assemblies 19, 20 and 21 4144 orf19.4144 Predicted ORF in Assemblies 19, 20 and 21; clade-associated gene expression 4148 orf19.4148 Predicted ORF in Assemblies 19, 20 and 21 4149 orf19.4149 Predicted ORF in Assemblies 19, 20 and 21 4149.1 orf19.4149.1 ORF Predicted by Annotation Working Group 415 orf19.415 Predicted ORF in Assemblies 19, 20 and 21 4150 orf19.4150 Predicted ORF in Assemblies 19, 20 and 21; induced by nitric oxide 4153 orf19.4153 Predicted ORF in Assemblies 19, 20 and 21 4154 orf19.4154 Predicted ORF from Assembly 19; merged with orf19.6298 in Assembly 20 4155.11 orf19.4155.11 ORF Predicted by Annotation Working Group; removed from Assembly 20 4155.12 orf19.4155.12 ORF Predicted by Annotation Working Group; removed from Assembly 20 4156 orf19.4156 Predicted ORF from Assembly 19; possibly spurious ORF (Annotation Working Group prediction); merged with orf19.4711 in Assembly 20 4159 orf19.4159 Predicted ORF in Assemblies 19, 20 and 21 416 orf19.416 Predicted ORF in Assemblies 19, 20 and 21 4160 orf19.4160 Predicted ORF in Assemblies 19, 20 and 21 4161 orf19.4161 Predicted ORF in Assemblies 19, 20 and 21 4163 orf19.4163 Predicted ORF in Assemblies 19, 20 and 21 4164 orf19.4164 Predicted ORF in Assemblies 19, 20 and 21 4166 orf19.4166 Predicted zinc-finger protein of unknown function 4167 orf19.4167 Predicted ORF in Assemblies 19, 20 and 21 4168 orf19.4168 Predicted ORF in Assemblies 19, 20 and 21 4169 orf19.4169 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 417 orf19.417 Predicted ORF in Assemblies 19, 20 and 21 4170 orf19.4170 Predicted ORF in Assemblies 19, 20 and 21 4171 orf19.4171 Predicted ORF in Assemblies 19, 20 and 21 4172 orf19.4172 Predicted ORF in Assemblies 19, 20 and 21 4173 orf19.4173 Predicted ORF in Assemblies 19, 20 and 21 4174 orf19.4174 Predicted ORF in Assemblies 19, 20 and 21 4176 orf19.4176 Predicted ORF in Assemblies 19, 20 and 21 4179 orf19.4179 Predicted ORF in Assemblies 19, 20 and 21 4180 orf19.4180 Protein described as component of ER protein-translocation complex; regulated by Gcn4p; repressed in response to amino acid starvation (3-aminotriazole treatment) 4182 orf19.4182 Predicted ORF in Assemblies 19, 20 and 21 4184 orf19.4184 Predicted ORF in Assemblies 19, 20 and 21 4185 orf19.4185 Predicted ORF in Assemblies 19, 20 and 21 4187 orf19.4187 Predicted ORF in Assemblies 19, 20 and 21 4189 orf19.4189 Predicted ORF in Assemblies 19, 20 and 21 419 orf19.419 Predicted ORF in Assemblies 19, 20 and 21 4190 orf19.4190 Predicted ORF in Assemblies 19, 20 and 21 4191.1 orf19.4191.1 ORF Predicted by Annotation Working Group 4192.1 orf19.4192.1 Predicted ORF in Assembly 20 and 21; gene has intron 4193 orf19.4193 Predicted ORF in Assemblies 19, 20 and 21 4194 orf19.4194 Predicted ORF in Assemblies 19, 20 and 21 4195 orf19.4195 Predicted ORF in Assemblies 19, 20 and 21 4196 orf19.4196 Predicted ORF in Assemblies 19, 20 and 21 4199 orf19.4199 Predicted ORF in Assemblies 19, 20 and 21 42 orf19.42 Predicted ORF from Assembly 19; removed from Assembly 20 420 orf19.420 ORF Predicted by Annotation Working Group 4200 orf19.4200 Predicted ORF in Assemblies 19, 20 and 21 4203 orf19.4203 Predicted ORF in Assemblies 19, 20 and 21 4204 orf19.4204 Predicted ORF in Assemblies 19, 20 and 21 4205.1 orf19.4205.1 ORF Predicted by Annotation Working Group 4206 orf19.4206 Predicted ORF in Assemblies 19, 20 and 21 4207 orf19.4207 Predicted ORF from Assembly 19; removed from Assembly 20 4209 orf19.4209 Predicted ORF in Assemblies 19, 20 and 21 4210 orf19.4210 Predicted ORF in Assemblies 19, 20 and 21 4214 orf19.4214 Protein not essential for viability 4216 orf19.4216 Predicted ORF in Assemblies 19, 20 and 21; decreased expression in hyphae compared to yeast-form cells; transcription is increased in populations of cells exposed to fluconazole over multiple generations 4217 orf19.4217 ORF Predicted by Annotation Working Group 4220 orf19.4220 Predicted ORF in Assemblies 19, 20 and 21; regulated by Gcn4p; repressed in response to amino acid starvation (3-aminotriazole treatment) 4225.1 orf19.4225.1 ORF added to Assembly 21 based on comparative genome analysis 4227 orf19.4227 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 4228 orf19.4228 Predicted ORF in Assemblies 19, 20 and 21 4229 orf19.4229 Predicted ORF in Assemblies 19, 20 and 21 423 orf19.423 Predicted ORF in Assemblies 19, 20 and 21 4230 orf19.4230 Predicted ORF in Assemblies 19, 20 and 21; protein detected by mass spec in exponential and stationary phase cultures 4234 orf19.4234 Predicted ORF in Assemblies 19, 20 and 21 4239 orf19.4239 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 4240 orf19.4240 Predicted ORF in Assemblies 19, 20 and 21 4241 orf19.4241 Predicted ORF in Assemblies 19, 20 and 21 4243 orf19.4243 Predicted ORF in Assemblies 19, 20 and 21; not essential for viability; similar to S. cerevisiae Cue2p, which is a protein containing two CUE domains that bind ubiquitin 4244 orf19.4244 Protein not essential for viability 4245 orf19.4245 Predicted ORF in Assemblies 19, 20 and 21 4246 orf19.4246 Predicted ORF in Assemblies 19, 20 and 21; similar to S. cerevisiae Ykr070wp; transposon mutation affects filamentous growth; Hog1p-downregulated; shows colony morphology-related gene regulation by Ssn6p; induced during cell wall regeneration 4247 orf19.4247 Predicted ORF in Assemblies 19, 20 and 21 4248 orf19.4248 Predicted ORF in Assemblies 19, 20 and 21; regulated by Gcn4p; repressed in response to amino acid starvation (3-aminotriazole treatment) 425 orf19.425 Protein not essential for viability 4250 orf19.4250 Predicted ORF in Assemblies 19, 20 and 21 4251 orf19.4251 Predicted zinc-finger protein of unknown function 4252 orf19.4252 Predicted ORF in Assemblies 19, 20 and 21 4253 orf19.4253 Predicted ORF in Assemblies 19, 20 and 21 4258 orf19.4258 Putative protein of unknown function; heterozygous null mutant exhibits hypersensitivity to parnafungin and cordycepin in the C. albicans fitness test; predicted ORF in Assemblies 19, 20 and 21 426 orf19.426 Predicted ORF in Assemblies 19, 20 and 21 4262 orf19.4262 Predicted ORF in Assemblies 19, 20 and 21 4263 orf19.4263 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 4264 orf19.4264 Predicted ORF in Assemblies 19, 20 and 21 4267 orf19.4267 Predicted ORF from Assembly 19; merged with orf19.4266 in Assembly 20 4269 orf19.4269 Predicted ORF in Assemblies 19, 20 and 21 427 orf19.427 Predicted ORF in Assemblies 19, 20 and 21 4270 orf19.4270 Predicted ORF in Assemblies 19, 20 and 21 4271 orf19.4271 Predicted ORF from Assembly 19; removed from Assembly 20; subsequently reinstated in Assembly 21 based on comparative genome analysis 4273 orf19.4273 Predicted ORF in Assemblies 19, 20 and 21 4276 orf19.4276 Predicted ORF from Assembly 19; merged with orf19.4275 in Assembly 20 4278 orf19.4278 Predicted ORF in Assemblies 19, 20 and 21 428 orf19.428 Predicted ORF in Assemblies 19, 20 and 21; induced during planktonic growth 4280 orf19.4280 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 4281 orf19.4281 Predicted ORF in Assemblies 19, 20 and 21 4282 orf19.4282 Predicted ORF in Assemblies 19, 20 and 21; greater mRNA abundance observed in a cyr1 homozygous null mutant than in wild type; possibly spurious ORF (Annotation Working Group prediction) 4283 orf19.4283 Predicted ORF in Assemblies 19, 20 and 21 4285 orf19.4285 Predicted ORF from Assembly 19; not essential for viability; removed from Assembly 20 4286 orf19.4286 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 4287 orf19.4287 Predicted ORF in Assemblies 19, 20 and 21; clade-associated gene expression 429 orf19.429 Predicted ORF in Assemblies 19, 20 and 21; repressed by nitric oxide 4292 orf19.4292 Predicted ORF in Assemblies 19, 20 and 21 4293 orf19.4293 Predicted ORF in Assemblies 19, 20 and 21 4294 orf19.4294 Predicted ORF in Assemblies 19, 20 and 21 4295 orf19.4295 Predicted ORF in Assemblies 19, 20 and 21 43 orf19.43 Predicted ORF from Assembly 19; expression upregulated during planktonic growth; removed from Assembly 20 430 orf19.430 Predicted ORF in Assemblies 19, 20 and 21 4301 orf19.4301 Predicted ORF in Assemblies 19, 20 and 21 4305 orf19.4305 Predicted ORF in Assemblies 19, 20 and 21 4305.1 orf19.4305.1 ORF Predicted by Annotation Working Group 4306 orf19.4306 Predicted ORF in Assemblies 19, 20 and 21 4307 orf19.4307 Predicted ORF in Assemblies 19, 20 and 21 431 orf19.431 Putative transcription factor with zinc cluster DNA-binding motif 4310 orf19.4310 Predicted ORF in Assemblies 19, 20 and 21 4312 orf19.4312 Predicted ORF in Assemblies 19, 20 and 21 4315 orf19.4315 Predicted ORF in Assemblies 19, 20 and 21 4316 orf19.4316 Trimethyllysine dioxygenase, the first enzyme in the carnitine biosynthesis pathway; hyphal-induced expression, regulated by Cyr1p, Ras1p, Efg1p 432 orf19.432 Predicted ORF in Assemblies 19, 20 and 21 4320 orf19.4320 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 4321 orf19.4321 Predicted ORF in Assemblies 19, 20 and 21 4323 orf19.4323 Predicted ORF in Assemblies 19, 20 and 21 4324 orf19.4324 Predicted ORF in Assemblies 19, 20 and 21 4325 orf19.4325 Predicted ORF in Assemblies 19, 20 and 21 4326 orf19.4326 Predicted ORF in Assemblies 19, 20 and 21 433 orf19.433 Predicted ORF in Assemblies 19, 20 and 21 4330 orf19.4330 Predicted ORF in Assemblies 19, 20 and 21 4332 orf19.4332 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 4337 orf19.4337 Predicted membrane transporter, member of the monocarboxylate porter (MCP) family, major facilitator superfamily (MFS) 4338 orf19.4338 Predicted ORF from Assembly 19; merged with orf19.4337 in Assembly 20 4340 orf19.4340 Predicted ORF in Assemblies 19, 20 and 21 4340.1 orf19.4340.1 ORF Predicted by Annotation Working Group 4341 orf19.4341 Predicted ORF in Assemblies 19, 20 and 21 4346 orf19.4346 Predicted ORF in Assemblies 19, 20 and 21 4347 orf19.4347 Predicted ORF in Assemblies 19, 20 and 21; Hog1p-induced 4348 orf19.4348 Predicted ORF in Assemblies 19, 20 and 21 4349 orf19.4349 Protein of unknown function, transcription is repressed in the presence of elevated CO2; predicted ORF in Assemblies 19, 20 and 21 4349.6 orf19.4349.6 ORF Predicted by Annotation Working Group; removed from Assembly 20 4350 orf19.4350 Predicted ORF from Assembly 19; merged with orf19.4378 in Assembly 20 4355 orf19.4355 Predicted ORF in Assemblies 19, 20 and 21 4357 orf19.4357 Putative protein of unknown function; has similarity to S. cerevisiae Mgr3p, which is a subunit of the i-AAA protease supercomplex that degrades misfolded mitochondrial proteins; predicted ORF in Assemblies 19, 20 and 21 4358 orf19.4358 Predicted ORF in Assemblies 19, 20 and 21 4362 orf19.4362 Predicted ORF in Assemblies 19, 20 and 21 4365 orf19.4365 Predicted ORF in Assemblies 19, 20 and 21 4366 orf19.4366 Predicted ORF in Assemblies 19, 20 and 21 4368 orf19.4368 Predicted ORF in Assemblies 19, 20 and 21 4369 orf19.4369 Protein not essential for viability 4370 orf19.4370 Predicted ORF in Assemblies 19, 20 and 21; induced by nitric oxide; oxidative stress-induced via Cap1p; fungal-specific (no human or murine homolog) 4372 orf19.4372 Predicted ORF in Assemblies 19, 20 and 21 4373 orf19.4373 Protein similar to S. cerevisiae Fmn1p, which is riboflavin kinase; predicted Kex2p substrate 4375 orf19.4375 Predicted ORF in Assemblies 19, 20 and 21 4376 orf19.4376 Predicted ORF in Assemblies 19, 20 and 21 4378 orf19.4378 Predicted ORF in Assemblies 19, 20 and 21 438 orf19.438 Predicted ORF in Assemblies 19, 20 and 21 4380.1 orf19.4380.1 Predicted ORF in Assembly 20 and 21 (see Locus History) 4382 orf19.4382 Predicted ORF in Assemblies 19, 20 and 21 4383 orf19.4383 Predicted ORF in Assemblies 19, 20 and 21 4384.1 orf19.4384.1 Predicted ORF in Assembly 20; removed from Assembly 21 4386 orf19.4386 Predicted ORF from Assembly 19; regulated by Ssn6p; merged with orf19.4384 in Assembly 20 4387 orf19.4387 Predicted ORF from Assembly 19; removed from Assembly 20 4388 orf19.4388 Predicted ORF in Assemblies 19, 20 and 21; has histone fold domain; similar to TAFII47 proteins from S. cerevisiae, Danio rerio, Drosophila melanogaster, human, and mouse 439 orf19.439 Predicted ORF in Assemblies 19, 20 and 21 4390 orf19.4390 Predicted ORF in Assemblies 19, 20 and 21; transcription is repressed in response to alpha pheromone in SpiderM medium; transcriptionally activated by Mnl1p under weak acid stress 4391 orf19.4391 Predicted ORF in Assemblies 19, 20 and 21 4394 orf19.4394 Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium 4395 orf19.4395 Predicted ORF in Assemblies 19, 20 and 21; protein detected by mass spec in exponential and stationary phase cultures 4396 orf19.4396 Predicted ORF in Assemblies 19, 20 and 21 4398 orf19.4398 Predicted ORF in Assemblies 19, 20 and 21 4399 orf19.4399 Predicted ORF in Assemblies 19, 20 and 21 44 orf19.44 Predicted ORF from Assembly 19; removed from Assembly 20 4400 orf19.4400 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 4402 orf19.4402 Predicted ORF from Assembly 19; possibly spurious ORF (Annotation Working Group prediction); removed from Assembly 20 4406 orf19.4406 Predicted ORF in Assemblies 19, 20 and 21 4407 orf19.4407 Predicted ORF in Assemblies 19, 20 and 21 4409 orf19.4409 Protein not essential for viability 4412 orf19.4412 Predicted ORF in Assemblies 19, 20 and 21 4414 orf19.4414 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 4415 orf19.4415 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 4418.1 orf19.4418.1 ORF added to Assembly 21 based on comparative genome analysis 442 orf19.442 ORF Predicted by Annotation Working Group 4420 orf19.4420 Predicted ORF in Assemblies 19, 20 and 21 4421 orf19.4421 Processing alpha glucosidase I, involved in N-linked protein glycosylation and assembly of cell wall beta 1,6 glucan; merged with orf19.4719 in Assembly 20 4423 orf19.4423 Predicted ORF in Assemblies 19, 20 and 21 4428 orf19.4428 Protein not essential for viability 443 orf19.443 Predicted ORF in Assemblies 19, 20 and 21 4430 orf19.4430 Predicted ORF in Assemblies 19, 20 and 21 4435 orf19.4435 Predicted ORF in Assemblies 19, 20 and 21 4436 orf19.4436 Predicted ORF in Assemblies 19, 20 and 21 4437 orf19.4437 Predicted ORF in Assemblies 19, 20 and 21 4439 orf19.4439 Predicted ORF in Assemblies 19, 20 and 21 4439.1 orf19.4439.1 ORF Predicted by Annotation Working Group 444 orf19.444 Predicted ORF in Assemblies 19, 20 and 21 4441 orf19.4441 Predicted ORF in Assemblies 19, 20 and 21 4445 orf19.4445 Predicted ORF in Assemblies 19, 20 and 21; Plc1p-regulated 4446 orf19.4446 Protein similar to ammomium permeases that is probably inactive, as a mep2 mep3 double homozygous null mutation abolishes cellular ammomium permease activity; fungal-specific (no human or murine homolog) 4449 orf19.4449 Predicted ORF in Assemblies 19, 20 and 21 445 orf19.445 Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins 4450 orf19.4450 Predicted zinc-finger protein of unknown function 4450.1 orf19.4450.1 ORF Predicted by Annotation Working Group 4450.2 orf19.4450.2 ORF added to Assembly 21 based on comparative genome analysis 4455 orf19.4455 Predicted ORF in Assemblies 19, 20 and 21 4459 orf19.4459 Predicted ORF in Assemblies 19, 20 and 21; similar to S. cerevisiae Ynl234wp, which is a putative heme-binding stress-related protein; transposon mutation affects filamentous growth 446 orf19.446 Predicted ORF in Assemblies 19, 20 and 21; constitutive expression independent of MTL or white-opaque status; greater mRNA abundance observed in a cyr1 homozygous null mutant than in wild type; possibly spurious ORF (Annotation Working Group prediction) 446.1 orf19.446.1 Predicted ORF in Assembly 20 and 21; gene has intron 446.2 orf19.446.2 Predicted ORF in Assembly 20 and 21; gene has intron 4460 orf19.4460 Predicted ORF from Assembly 19; removed from Assembly 20 4461 orf19.4461 Predicted ORF in Assemblies 19, 20 and 21 4463 orf19.4463 Predicted ORF in Assemblies 19, 20 and 21 4465 orf19.4465 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 4466 orf19.4466 Predicted ORF in Assemblies 19, 20 and 21 4467 orf19.4467 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 4468 orf19.4468 Predicted ORF in Assemblies 19, 20 and 21 4469 orf19.4469 Predicted ORF from Assembly 19; removed from Assembly 20 4470 orf19.4470 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 4471 orf19.4471 Predicted ORF in Assemblies 19, 20 and 21 4472 orf19.4472 Predicted ORF in Assemblies 19, 20 and 21 4473 orf19.4473 Predicted ORF in Assemblies 19, 20 and 21 4474 orf19.4474 Protein not essential for viability 4476 orf19.4476 Predicted ORF in Assemblies 19, 20 and 21 4478 orf19.4478 Predicted ORF in Assemblies 19, 20 and 21 4479 orf19.4479 Predicted ORF in Assemblies 19, 20 and 21; downregulated during core stress response 448 orf19.448 Predicted ORF in Assemblies 19, 20 and 21 4480 orf19.4480 Predicted ORF from Assembly 19; merged with orf19.4479 in Assembly 20 4483 orf19.4483 Predicted ORF from Assembly 19; merged with orf19.4482 in Assembly 20 4484 orf19.4484 Predicted ORF from Assembly 19; possibly spurious ORF (Annotation Working Group prediction); removed from Assembly 20 4485 orf19.4485 Predicted ORF from Assembly 19; removed from Assembly 20 4486 orf19.4486 Predicted ORF from Assembly 19; removed from Assembly 20 4488 orf19.4488 Predicted ORF in Assemblies 19, 20 and 21 449 orf19.449 Predicted ORF in Assemblies 19, 20 and 21; possible phosphatidyl synthase; transcription reduced upon yeast-hyphal switch; protein detected by mass spec in stationary phase cultures 4492 orf19.4492 Predicted ORF in Assemblies 19, 20 and 21 4496 orf19.4496 Predicted ORF in Assemblies 19, 20 and 21 4498 orf19.4498 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 45 orf19.45 Predicted ORF from Assembly 19; merged with orf19.5742 in Assembly 20 450 orf19.450 Predicted ORF in Assemblies 19, 20 and 21 4502 orf19.4502 Predicted ORF in Assemblies 19, 20 and 21 4503 orf19.4503 Predicted ORF in Assemblies 19, 20 and 21 4504 orf19.4504 Predicted ORF in Assemblies 19, 20 and 21 4507 orf19.4507 Predicted ORF in Assemblies 19, 20 and 21 4508 orf19.4508 Predicted ORF in Assemblies 19, 20 and 21 4509 orf19.4509 Predicted ORF in Assemblies 19, 20 and 21 4511 orf19.4511 Predicted ORF in Assemblies 19, 20 and 21 4512 orf19.4512 Predicted ORF from Assembly 19; merged with orf19.4511 in Assembly 20 4513 orf19.4513 Protein not essential for viability; possibly spurious ORF (Annotation Working Group prediction) 4515 orf19.4515 Predicted ORF in Assemblies 19, 20 and 21 4516 orf19.4516 Predicted ORF in Assemblies 19, 20 and 21 4517 orf19.4517 Predicted ORF in Assemblies 19, 20 and 21 4518 orf19.4518 Protein not essential for viability 452 orf19.452 Predicted ORF from Assembly 19; removed from Assembly 20 4520 orf19.4520 Predicted ORF in Assemblies 19, 20 and 21 4521 orf19.4521 Predicted ORF in Assemblies 19, 20 and 21; hyphal-induced expression 4522 orf19.4522 Predicted ORF in Assemblies 19, 20 and 21 4523 orf19.4523 Predicted ORF in Assemblies 19, 20 and 21 4524 orf19.4524 Predicted zinc-finger protein of unknown function; caspofungin induced 4525 orf19.4525 Predicted ORF in Assemblies 19, 20 and 21 4528 orf19.4528 Predicted ORF in Assemblies 19, 20 and 21 4529 orf19.4529 Protein not essential for viability 453 orf19.453 Predicted ORF from Assembly 19; removed from Assembly 20 4530.1 orf19.4530.1 ORF Predicted by Annotation Working Group; regulated by Nrg1p, Tup1p 4531 orf19.4531 Putative PDR-subfamily ABC transporter 4532 orf19.4532 Predicted ORF in Assemblies 19, 20 and 21; protein detected by mass spec in exponential and stationary phase cultures 4533 orf19.4533 Predicted ORF in Assemblies 19, 20 and 21 4534 orf19.4534 Predicted ORF in Assemblies 19, 20 and 21; macrophage-downregulated gene 4537 orf19.4537 Predicted ORF in Assemblies 19, 20 and 21 4538 orf19.4538 Predicted ORF in Assemblies 19, 20 and 21 4539 orf19.4539 Predicted ORF in Assemblies 19, 20 and 21 4542 orf19.4542 Predicted ORF in Assemblies 19, 20 and 21 4544 orf19.4544 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 4550 orf19.4550 Predicted membrane transporter, member of the drug:proton antiporter (12 spanner) (DHA1) family, major facilitator superfamily (MFS) 4552 orf19.4552 Predicted ORF from Assembly 19; removed from Assembly 20 4553 orf19.4553 Predicted ORF in Assemblies 19, 20 and 21 4556 orf19.4556 Putative GPI-anchored protein, member of the ALS gene family; ketoconazole induced; caspofungin repressed; merged with orf19.4555 in Assembly 20 4557 orf19.4557 Predicted ORF in Assemblies 19, 20 and 21 4558 orf19.4558 Predicted ORF from Assembly 19; merged with orf19.2775 in Assembly 20 4563 orf19.4563 Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins 4566 orf19.4566 Protein similar to S. cerevisiae Rot1p, which has roles in cytoskeletal dynamics and cell wall biosynthesis; predicted Kex2p substrate 4567 orf19.4567 Catechol 1,2-dioxygenase (1,2-CTD), involved in degradation of aromatic compounds 4569 orf19.4569 Predicted ORF in Assemblies 19, 20 and 21 457 orf19.457 Predicted ORF in Assemblies 19, 20 and 21 4570 orf19.4570 Predicted ORF in Assemblies 19, 20 and 21 4571 orf19.4571 Predicted ORF in Assemblies 19, 20 and 21 4573 orf19.4573 Putative transcription factor with zinc cluster DNA-binding motif; transcription is induced in response to alpha pheromone in SpiderM medium 4574 orf19.4574 Predicted ORF in Assemblies 19, 20 and 21 4575 orf19.4575 Predicted ORF in Assemblies 19, 20 and 21 4577 orf19.4577 Predicted ORF in Assemblies 19, 20 and 21 4577.3 orf19.4577.3 ORF Predicted by Annotation Working Group 4579 orf19.4579 Predicted ORF in Assemblies 19, 20 and 21 458 orf19.458 Predicted ORF in Assemblies 19, 20 and 21 458.1 orf19.458.1 ORF added to Assembly 21 based on comparative genome analysis 4580 orf19.4580 Predicted ORF in Assemblies 19, 20 and 21 4581 orf19.4581 Predicted ORF in Assemblies 19, 20 and 21; regulated by Tsa1p, Tsa1Bp under H2O2 stress conditions 4582 orf19.4582 Predicted ORF in Assemblies 19, 20 and 21 4583 orf19.4583 Predicted ORF in Assemblies 19, 20 and 21 4589 orf19.4589 Predicted ORF in Assemblies 19, 20 and 21 4593.1 orf19.4593.1 ORF Predicted by Annotation Working Group 4594 orf19.4594 Predicted ORF in Assemblies 19, 20 and 21 4595 orf19.4595 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 4596 orf19.4596 Predicted ORF in Assemblies 19, 20 and 21 4597 orf19.4597 Predicted ORF in Assemblies 19, 20 and 21 4600 orf19.4600 Predicted ORF in Assemblies 19, 20 and 21 4600.1 orf19.4600.1 ORF Predicted by Annotation Working Group 4601 orf19.4601 Predicted ORF in Assemblies 19, 20 and 21 4604 orf19.4604 ORF Predicted by Annotation Working Group; removed from Assembly 20 4607 orf19.4607 Predicted ORF in Assemblies 19, 20 and 21; hyphal induced 4609 orf19.4609 Protein abundance is affected by URA3 expression in the CAI-4 strain background; protein detected by mass spec in exponential and stationary phase cultures 461 orf19.461 Protein similar to S. cerevisiae Mhp1p, which is involved in microtubule stabilization; transposon mutation affects filamentous growth; merged with orf19.6621 in Assembly 20 4610 orf19.4610 Predicted ORF in Assemblies 19, 20 and 21 4610.1 orf19.4610.1 ORF Predicted by Annotation Working Group; merged with orf19.4555 in Assembly 20 4611 orf19.4611 Predicted ORF in Assemblies 19, 20 and 21 4612 orf19.4612 Predicted ORF in Assemblies 19, 20 and 21 4614 orf19.4614 Predicted ORF in Assemblies 19, 20 and 21 4615 orf19.4615 Predicted ORF in Assemblies 19, 20 and 21 4617 orf19.4617 Predicted ORF in Assemblies 19, 20 and 21 462 orf19.462 Predicted ORF from Assembly 19; removed from Assembly 20 4620 orf19.4620 Predicted ORF in Assemblies 19, 20 and 21 4621 orf19.4621 Predicted ORF in Assemblies 19, 20 and 21; fungal-specific (no human or murine homolog) 4622 orf19.4622 Predicted ORF in Assemblies 19, 20 and 21 4623 orf19.4623 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 4626 orf19.4626 Predicted ORF in Assemblies 19, 20 and 21 4627 orf19.4627 Predicted ORF in Assemblies 19, 20 and 21 4628 orf19.4628 Putative protein of unknown function; heterozygous null mutant exhibits hypersensitivity to parnafungin and cordycepin in the C. albicans fitness test; predicted ORF in Assemblies 19, 20 and 21 4629 orf19.4629 Predicted ORF in Assemblies 19, 20 and 21 4633 orf19.4633 Predicted ORF in Assemblies 19, 20 and 21 4634 orf19.4634 Predicted ORF in Assemblies 19, 20 and 21 4636 orf19.4636 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 4637 orf19.4637 Predicted ORF in Assemblies 19, 20 and 21 4638 orf19.4638 Predicted ORF from Assembly 19; merged with orf19.4637 in Assembly 20 4639 orf19.4639 Predicted ORF in Assemblies 19, 20 and 21; protein detected by mass spec in exponential and stationary phase cultures 4642 orf19.4642 Predicted ORF in Assemblies 19, 20 and 21 4643 orf19.4643 Predicted ORF in Assemblies 19, 20 and 21 4649 orf19.4649 Putative transcription factor with zinc cluster DNA-binding motif 4652 orf19.4652 Predicted ORF in Assemblies 19, 20 and 21 4653 orf19.4653 Transcriptionally regulated by iron; expression greater in low iron; similar to GPI-linked cell-wall proteins 4654 orf19.4654 Predicted ORF in Assemblies 19, 20 and 21 4656 orf19.4656 Predicted ORF in Assemblies 19, 20 and 21 4657 orf19.4657 Predicted ORF in Assemblies 19, 20 and 21 4658 orf19.4658 Protein not essential for viability 4659 orf19.4659 Predicted ORF in Assemblies 19, 20 and 21 4661 orf19.4661 Predicted ORF from Assembly 19; removed from Assembly 20 4664 orf19.4664 Predicted ORF in Assemblies 19, 20 and 21 4665 orf19.4665 Predicted ORF in Assemblies 19, 20 and 21 4666 orf19.4666 Predicted ORF in Assemblies 19, 20 and 21; hyphal-induced expression, regulated by Cyr1p, Ras1p, Efg1p; possibly spurious ORF (Annotation Working Group prediction) 4668 orf19.4668 Protein not essential for viability 467 orf19.467 Predicted ORF in Assemblies 19, 20 and 21 4672 orf19.4672 Predicted ORF in Assemblies 19, 20 and 21 4674 orf19.4674 Predicted ORF from Assembly 19; merged with orf19.4673 in Assembly 20 4675 orf19.4675 Predicted ORF in Assemblies 19, 20 and 21 4676 orf19.4676 Predicted ORF in Assemblies 19, 20 and 21 4677 orf19.4677 Putative protein of unknown function, transcription is upregulated in clinical isolates from HIV+ patients with oral candidiasis; predicted ORF in Assemblies 19, 20 and 21 4678 orf19.4678 Predicted ORF in Assemblies 19, 20 and 21 468 orf19.468 Predicted ORF from Assembly 19; removed from Assembly 20 4680 orf19.4680 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to toxic ergosterol analog 4685 orf19.4685 Predicted ORF in Assemblies 19, 20 and 21 4686 orf19.4686 Predicted ORF in Assemblies 19, 20 and 21 4690 orf19.4690 Predicted ORF in Assemblies 19, 20 and 21; induced by nitric oxide in yhb1 mutant 4691 orf19.4691 Predicted ORF in Assemblies 19, 20 and 21 4699 orf19.4699 Putative phospholipase of patatin family; similar to S. cerevisiae Ymr313p; predicted Kex2p substrate 47 orf19.47 Predicted ORF from Assembly 19; removed from Assembly 20 470 orf19.470 Predicted ORF in Assemblies 19, 20 and 21 4700 orf19.4700 Predicted ORF from Assembly 19; merged with orf19.4699 in Assembly 20 4701 orf19.4701 Predicted ORF in Assemblies 19, 20 and 21 4702 orf19.4702 Predicted ORF in Assemblies 19, 20 and 21; expression regulated during planktonic growth; similarity to mutator-like element (MULE) transposase; possibly spurious ORF (Annotation Working Group prediction) 4703 orf19.4703 Predicted ORF in Assemblies 19, 20 and 21; has similarity to mutator-like element (MULE) transposase 4705 orf19.4705 Predicted ORF in Assemblies 19, 20 and 21 4706 orf19.4706 Predicted ORF in Assemblies 19, 20 and 21; greater mRNA abundance observed in a cyr1 or ras1 homozygous null mutant than in wild type; fluconazole-induced; transcription is induced in response to alpha pheromone in SpiderM medium 4707 orf19.4707 Putative secreted acid sphingomyelin phosphodiesterase; possible Kex2p substrate 4711 orf19.4711 Predicted ORF in Assemblies 19, 20 and 21 4713 orf19.4713 Predicted ORF in Assemblies 19, 20 and 21 4715 orf19.4715 Predicted ORF in Assemblies 19, 20 and 21 4721 orf19.4721 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 4722 orf19.4722 Predicted ORF in Assemblies 19, 20 and 21 4723 orf19.4723 Predicted ORF in Assemblies 19, 20 and 21 4724 orf19.4724 Predicted ORF in Assemblies 19, 20 and 21 4726 orf19.4726 Predicted ORF in Assemblies 19, 20 and 21 4727 orf19.4727 Predicted ORF in Assemblies 19, 20 and 21 4728 orf19.4728 Predicted ORF in Assemblies 19, 20 and 21 4729 orf19.4729 Predicted ORF from Assembly 19; merged with orf19.4728 in Assembly 20 4730 orf19.4730 Predicted ORF in Assemblies 19, 20 and 21 4731 orf19.4731 Predicted ORF in Assemblies 19, 20 and 21 4734 orf19.4734 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 4735 orf19.4735 Predicted ORF in Assemblies 19, 20 and 21 4736 orf19.4736 Predicted ORF in Assemblies 19, 20 and 21 4738 orf19.4738 Predicted ORF in Assemblies 19, 20 and 21 474 orf19.474 Predicted ORF in Assemblies 19, 20 and 21 4740 orf19.4740 Predicted ORF in Assemblies 19, 20 and 21 4741 orf19.4741 Predicted ORF in Assemblies 19, 20 and 21; possibly C. albicans-specific 4742 orf19.4742 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 4744 orf19.4744 Predicted ORF in Assemblies 19, 20 and 21; transcription is repressed in response to alpha pheromone in SpiderM medium 4748 orf19.4748 Putative U2B'' component of the U2 snRNP, involved in splicing; contains an RNA recognition motif (RRM); ortholog of S. cerevisiae MSL1; predicted ORF in Assemblies 19, 20 and 21 4749 orf19.4749 Predicted ORF in Assemblies 19, 20 and 21; hyphal-induced expression, regulated by Cyr1p, Ras1p, Efg1p 475 orf19.475 Predicted ORF in Assemblies 19, 20 and 21 4750 orf19.4750 Predicted ORF in Assemblies 19, 20 and 21 4751 orf19.4751 Predicted ORF in Assemblies 19, 20 and 21 4751.1 orf19.4751.1 ORF added to Assembly 21 based on comparative genome analysis 4756 orf19.4756 Predicted ORF in Assemblies 19, 20 and 21; fungal-specific 4758 orf19.4758 Predicted ORF in Assemblies 19, 20 and 21; alkaline downregulated 476 orf19.476 Predicted ORF from Assembly 19; merged with orf19.475 in Assembly 20 4760 orf19.4760 Predicted ORF in Assemblies 19, 20 and 21 4761 orf19.4761 Predicted ORF in Assemblies 19, 20 and 21 4763 orf19.4763 Protein not essential for viability 4764 orf19.4764 Predicted ORF in Assemblies 19, 20 and 21 4766 orf19.4766 Putative transcription factor with zinc cluster DNA-binding motif; has similarity to S. cerevisiae Arg81p, which is a transcription factor involved in the regulation of arginine-responsive genes 4767 orf19.4767 Putative transcription factor with zinc cluster DNA-binding motif 4768 orf19.4768 Predicted ORF in Assemblies 19, 20 and 21 477 orf19.477 Predicted ORF in Assemblies 19, 20 and 21 4770 orf19.4770 Predicted ORF from Assembly 19; merged with orf19.4769 in Assembly 20 4771 orf19.4771 Predicted ORF in Assemblies 19, 20 and 21 4776 orf19.4776 Putative transcription factor with zinc cluster DNA-binding motif; has similarity to S. cerevisiae Lys14p, which is a transcription factor involved in the regulation of lysine biosynthesis genes 4778 orf19.4778 Putative transcription factor with zinc cluster DNA-binding motif; has similarity to S. cerevisiae Lys14p, which is a transcription factor involved in the regulation of lysine biosynthesis genes; fungal-specific 4779 orf19.4779 Putative transporter; slightly similar to the Sit1p siderophore transporter; Gcn4p-regulated; fungal-specific (no human or murine homolog); transcriptionally activated by Mnl1p under weak acid stress 478 orf19.478 Predicted ORF in Assemblies 19, 20 and 21 4780 orf19.4780 Predicted membrane transporter, member of the drug:proton antiporter (12 spanner) (DHA1) family, major facilitator superfamily (MFS) 4783 orf19.4783 Predicted ORF in Assemblies 19, 20 and 21 4787 orf19.4787 Predicted ORF in Assemblies 19, 20 and 21 4789 orf19.4789 Predicted ORF in Assemblies 19, 20 and 21 479 orf19.479 Predicted ORF from Assembly 19; merged with orf19.478 in Assembly 20 479.2 orf19.479.2 ORF Predicted by Annotation Working Group 4790 orf19.4790 Predicted ORF from Assembly 19; removed from Assembly 20 4791 orf19.4791 Predicted ORF in Assemblies 19, 20 and 21 4792 orf19.4792 Predicted ORF in Assemblies 19, 20 and 21; Plc1p-regulated; possibly spurious ORF (Annotation Working Group prediction) 4793 orf19.4793 Predicted ORF in Assemblies 19, 20 and 21 4794 orf19.4794 Predicted ORF from Assembly 19; removed from Assembly 20 4795 orf19.4795 Predicted ORF in Assemblies 19, 20 and 21 4796 orf19.4796 Predicted ORF in Assemblies 19, 20 and 21; protein detected by mass spec in stationary phase cultures 4798 orf19.4798 Predicted ORF in Assemblies 19, 20 and 21 4799 orf19.4799 Predicted ORF in Assemblies 19, 20 and 21 48 orf19.48 Predicted ORF in Assemblies 19, 20 and 21; likely to be essential for growth, based on an insertional mutagenesis strategy; virulence-group-correlated expression 480 orf19.480 Predicted ORF in Assemblies 19, 20 and 21 4801 orf19.4801 Predicted ORF in Assemblies 19, 20 and 21 4803 orf19.4803 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 4805 orf19.4805 Predicted ORF in Assemblies 19, 20 and 21; fungal-specific (no human or murine homolog); transcription is induced in response to alpha pheromone in SpiderM medium 4807 orf19.4807 Predicted ORF in Assemblies 19, 20 and 21 4811 orf19.4811 Predicted ORF in Assemblies 19, 20 and 21 4812 orf19.4812 Predicted ORF in Assemblies 19, 20 and 21 4814 orf19.4814 Predicted ORF in Assemblies 19, 20 and 21 4816 orf19.4816 Predicted ORF in Assemblies 19, 20 and 21; induced by nitric oxide 4818 orf19.4818 Predicted ORF in Assemblies 19, 20 and 21 4819 orf19.4819 Predicted ORF in Assemblies 19, 20 and 21 4820 orf19.4820 Predicted ORF in Assemblies 19, 20 and 21 4824 orf19.4824 Predicted ORF in Assemblies 19, 20 and 21 4825 orf19.4825 Predicted ORF in Assemblies 19, 20 and 21 4828 orf19.4828 Predicted ORF in Assemblies 19, 20 and 21 4830 orf19.4830 Predicted ORF in Assemblies 19, 20 and 21 4831 orf19.4831 Predicted ORF in Assemblies 19, 20 and 21 4834 orf19.4834 Predicted ORF in Assemblies 19, 20 and 21 4835 orf19.4835 Predicted ORF in Assemblies 19, 20 and 21 4837 orf19.4837 Predicted ORF in Assemblies 19, 20 and 21 4837.1 orf19.4837.1 ORF added to Assembly 21 based on comparative genome analysis 4839 orf19.4839 Predicted ORF in Assemblies 19, 20 and 21; decreased expression observed in an ssr1 homozygous null mutant 4842 orf19.4842 Predicted ORF in Assemblies 19, 20 and 21 4843 orf19.4843 Predicted ORF in Assemblies 19, 20 and 21 4844 orf19.4844 Predicted ORF in Assemblies 19, 20 and 21 4845 orf19.4845 Predicted ORF in Assemblies 19, 20 and 21; fluconazole-induced 4846 orf19.4846 Protein not essential for viability 4847 orf19.4847 ORF Predicted by Annotation Working Group 4849 orf19.4849 Predicted ORF in Assemblies 19, 20 and 21 485 orf19.485 Predicted ORF in Assemblies 19, 20 and 21 4850 orf19.4850 Predicted ORF in Assemblies 19, 20 and 21 4857 orf19.4857 Predicted ORF in Assemblies 19, 20 and 21 4859 orf19.4859 Predicted ORF from Assembly 19; merged with orf19.4858 in Assembly 20 4860 orf19.4860 Predicted ORF from Assembly 19; merged with orf19.4858 in Assembly 20 4861 orf19.4861 Predicted ORF in Assemblies 19, 20 and 21 4861.1 orf19.4861.1 ORF Predicted by Annotation Working Group 4862 orf19.4862 Predicted ORF in Assemblies 19, 20 and 21 4862.2 orf19.4862.2 ORF Predicted by Annotation Working Group 4864 orf19.4864 Predicted ORF in Assemblies 19, 20 and 21 4865 orf19.4865 Predicted ORF in Assemblies 19, 20 and 21 4872 orf19.4872 Protein not essential for viability; possibly spurious ORF (Annotation Working Group prediction); transcriptionally activated by Mnl1p under weak acid stress 4873 orf19.4873 Predicted ORF in Assemblies 19, 20 and 21; expression is regulated upon white-opaque switching 4875 orf19.4875 Predicted ORF in Assemblies 19, 20 and 21 4878 orf19.4878 Predicted ORF in Assemblies 19, 20 and 21 4880 orf19.4880 Predicted ORF in Assemblies 19, 20 and 21 4881 orf19.4881 Predicted ORF from Assembly 19; merged with orf19.4880 in Assembly 20 4882 orf19.4882 Predicted ORF in Assemblies 19, 20 and 21 4883 orf19.4883 Predicted ORF in Assemblies 19, 20 and 21; constitutive expression independent of MTL or white-opaque status 4886 orf19.4886 Predicted ORF in Assemblies 19, 20 and 21 4888 orf19.4888 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 4889 orf19.4889 Predicted membrane transporter, member of the drug:proton antiporter (12 spanner) (DHA1) family, major facilitator superfamily (MFS) 4893 orf19.4893 Protein not essential for viability 4894 orf19.4894 Protein of unknown function, has similarity to S. cerevisiae Yer010cp, which is a protein of unknown function belonging to the prokaryotic RraA family; decreased transcription is observed upon benomyl treatment 4895 orf19.4895 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 4896 orf19.4896 Predicted ORF in Assemblies 19, 20 and 21 4897 orf19.4897 Predicted ORF in Assemblies 19, 20 and 21 4898 orf19.4898 Predicted ORF in Assemblies 19, 20 and 21; increased expression in response to prostaglandins 490 orf19.490 Predicted ORF in Assemblies 19, 20 and 21 4900 orf19.4900 Predicted ORF in Assemblies 19, 20 and 21 4901 orf19.4901 Predicted ORF in Assemblies 19, 20 and 21; merged with orf19.4902 in Assembly 21 4902 orf19.4902 Predicted ORF from Assembly 19; removed from Assembly 20; subsequently merged with orf19.4901 in Assembly 21 4903 orf19.4903 Predicted ORF in Assemblies 19, 20 and 21 4904 orf19.4904 Predicted ORF in Assemblies 19, 20 and 21 4905 orf19.4905 Predicted ORF in Assemblies 19, 20 and 21; decreased expression observed in an ssr1 homozygous null mutant 4906 orf19.4906 Putative protein of unknown function, transcription is positively regulated by Tbf1p; predicted ORF in Assemblies 19, 20 and 21 4907 orf19.4907 Predicted ORF in Assemblies 19, 20 and 21; increased transcription is observed upon fluphenazine treatment; possibly transcriptionally regulated by Tac1p; induced by nitric oxide; fungal-specific (no human or murine homolog) 4908 orf19.4908 Predicted ORF in Assemblies 19, 20 and 21 491 orf19.491 Predicted ORF in Assemblies 19, 20 and 21 4911 orf19.4911 Predicted ORF in Assemblies 19, 20 and 21 4912 orf19.4912 Predicted ORF in Assemblies 19, 20 and 21 4913 orf19.4913 Predicted ORF in Assemblies 19, 20 and 21 4914 orf19.4914 Predicted ORF in Assemblies 19, 20 and 21 4914.1 orf19.4914.1 ORF added to Assembly 21 based on comparative genome analysis 4916 orf19.4916 Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium 4917 orf19.4917 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 4918 orf19.4918 Predicted ORF in Assemblies 19, 20 and 21 4919 orf19.4919 Predicted ORF in Assemblies 19, 20 and 21 4920 orf19.4920 Predicted ORF from Assembly 19; merged with orf19.4919 in Assembly 20 4921 orf19.4921 Predicted ORF in Assemblies 19, 20 and 21 4921.1 orf19.4921.1 ORF added to Assembly 21 based on comparative genome analysis 4922 orf19.4922 Predicted ORF in Assemblies 19, 20 and 21 4923 orf19.4923 Predicted membrane transporter, member of the sugar porter (SP) family, major facilitator superfamily (MFS); caspofungin induced 4923.1 orf19.4923.1 ORF added to Assembly 21 based on comparative genome analysis 4924 orf19.4924 Predicted ORF in Assemblies 19, 20 and 21; decreased expression observed in an ssr1 homozygous null mutant 4928 orf19.4928 Predicted ORF in Assemblies 19, 20 and 21 4929 orf19.4929 Predicted ORF in Assemblies 19, 20 and 21 4931 orf19.4931 Putative tRNA-Cys synthetase; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage; transcription is induced in response to alpha pheromone in SpiderM medium 4932 orf19.4932 Predicted ORF in Assemblies 19, 20 and 21 4936 orf19.4936 Predicted ORF in Assemblies 19, 20 and 21 4936.1 orf19.4936.1 ORF added to Assembly 21 based on comparative genome analysis 4938 orf19.4938 Predicted ORF from Assembly 19; merged with orf19.4937 in Assembly 20 4939 orf19.4939 Predicted ORF in Assemblies 19, 20 and 21 494 orf19.494 Predicted ORF in Assemblies 19, 20 and 21 4940 orf19.4940 Putative histidine permease; fungal-specific (no human or murine homolog) 4942 orf19.4942 Predicted ORF in Assemblies 19, 20 and 21 4946 orf19.4946 Predicted ORF in Assemblies 19, 20 and 21 4947 orf19.4947 Predicted ORF in Assemblies 19, 20 and 21 4948 orf19.4948 Predicted ORF in Assemblies 19, 20 and 21 4949 orf19.4949 Predicted ORF in Assemblies 19, 20 and 21 4951 orf19.4951 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 4952 orf19.4952 Predicted ORF in Assemblies 19, 20 and 21 4952.1 orf19.4952.1 ORF Predicted by Annotation Working Group 4953 orf19.4953 Predicted ORF in Assemblies 19, 20 and 21 4954 orf19.4954 Predicted ORF in Assemblies 19, 20 and 21 4955 orf19.4955 Predicted ORF in Assemblies 19, 20 and 21 4959 orf19.4959 Predicted ORF in Assemblies 19, 20 and 21 496 orf19.496 Predicted ORF in Assemblies 19, 20 and 21 4960 orf19.4960 Predicted ORF in Assemblies 19, 20 and 21 4962 orf19.4962 Predicted ORF in Assemblies 19, 20 and 21 4963 orf19.4963 Predicted ORF in Assemblies 19, 20 and 21 4964 orf19.4964 Predicted ORF in Assemblies 19, 20 and 21 4965 orf19.4965 Predicted ORF in Assemblies 19, 20 and 21 4966 orf19.4966 Protein not essential for viability; transcription is alkaline upregulated 4970 orf19.4970 Predicted ORF in Assemblies 19, 20 and 21 4972 orf19.4972 Putative transcription factor with zinc finger DNA-binding motif 4976 orf19.4976 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 498 orf19.498 Predicted ORF in Assemblies 19, 20 and 21 4981 orf19.4981 Predicted ORF in Assemblies 19, 20 and 21 4982 orf19.4982 Predicted ORF in Assemblies 19, 20 and 21 4983 orf19.4983 Predicted ORF in Assemblies 19, 20 and 21 4984 orf19.4984 Predicted ORF in Assemblies 19, 20 and 21 4988 orf19.4988 Predicted ORF in Assemblies 19, 20 and 21; greater mRNA abundance observed in a cyr1 homozygous null mutant than in wild type 4989 orf19.4989 Predicted ORF from Assembly 19; removed from Assembly 20 499 orf19.499 Predicted ORF in Assemblies 19, 20 and 21 4994 orf19.4994 Predicted ORF from Assembly 19; merged with orf19.4993 in Assembly 20 4995 orf19.4995 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 4996 orf19.4996 Predicted ORF in Assemblies 19, 20 and 21 4998 orf19.4998 Predicted ORF in Assemblies 19, 20 and 21; caspofungin repressed 5 orf19.5 Predicted ORF from Assembly 19; removed from Assembly 20 50 orf19.50 Predicted ORF in Assemblies 19, 20 and 21 500 orf19.500 Predicted ORF in Assemblies 19, 20 and 21 5003 orf19.5003 Predicted ORF in Assemblies 19, 20 and 21 5006.1 orf19.5006.1 ORF Predicted by Annotation Working Group 5008.1 orf19.5008.1 ORF Predicted by Annotation Working Group 5009 orf19.5009 Predicted ORF in Assemblies 19, 20 and 21 501 orf19.501 Predicted ORF in Assemblies 19, 20 and 21 5012 orf19.5012 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 5014 orf19.5014 Predicted ORF in Assemblies 19, 20 and 21 5016 orf19.5016 Protein not essential for viability 5017 orf19.5017 Predicted ORF in Assemblies 19, 20 and 21 5019 orf19.5019 Predicted ORF in Assemblies 19, 20 and 21 5020 orf19.5020 Predicted ORF in Assemblies 19, 20 and 21 5022 orf19.5022 Predicted ORF in Assemblies 19, 20 and 21 5026 orf19.5026 Putative transcription factor with zinc finger DNA-binding motif 5030 orf19.5030 Predicted ORF in Assemblies 19, 20 and 21; induced during planktonic growth 5033 orf19.5033 Predicted ORF in Assemblies 19, 20 and 21 5034 orf19.5034 Predicted ORF in Assemblies 19, 20 and 21 5035 orf19.5035 Predicted ORF in Assemblies 19, 20 and 21 5036 orf19.5036 Predicted ORF from Assembly 19; merged with orf19.1297 in Assembly 20 5037 orf19.5037 Protein not essential for viability 5038 orf19.5038 Predicted ORF in Assemblies 19, 20 and 21 5039 orf19.5039 Predicted ORF in Assemblies 19, 20 and 21 504 orf19.504 Predicted ORF in Assemblies 19, 20 and 21 5040 orf19.5040 Predicted ORF in Assemblies 19, 20 and 21 5041 orf19.5041 Predicted ORF in Assemblies 19, 20 and 21 5042 orf19.5042 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 5043 orf19.5043 Predicted ORF in Assemblies 19, 20 and 21 5045 orf19.5045 Predicted ORF in Assemblies 19, 20 and 21; transcriptionally activated by Mnl1p under weak acid stress 5047 orf19.5047 Predicted ORF from Assembly 19; possibly spurious ORF (Annotation Working Group prediction); merged with orf19.4713 in Assembly 20 5049 orf19.5049 Predicted ORF in Assemblies 19, 20 and 21; induced upon biofilm formation 5051 orf19.5051 Predicted ORF in Assemblies 19, 20 and 21 5052 orf19.5052 Predicted ORF in Assemblies 19, 20 and 21 5053 orf19.5053 Predicted ORF in Assemblies 19, 20 and 21 5054 orf19.5054 Putative quinolinate phosphoribosyl transferase, involved in NAD biosynthesis 5056 orf19.5056 Predicted ORF in Assemblies 19, 20 and 21 5057 orf19.5057 Predicted ORF in Assemblies 19, 20 and 21 5060 orf19.5060 Predicted ORF from Assembly 19; merged with orf19.5059 in Assembly 20 5062 orf19.5062 Predicted ORF from Assembly 19; merged with orf19.5061 in Assembly 20 5063 orf19.5063 Predicted ORF in Assemblies 19, 20 and 21; ciclopirox olamine induced; regulated by Ssn6p; induced by nitric oxide in yhb1 mutant 5064.1 orf19.5064.1 ORF added to Assembly 21 based on comparative genome analysis 5065 orf19.5065 Predicted ORF in Assemblies 19, 20 and 21 5066 orf19.5066 Predicted ORF in Assemblies 19, 20 and 21; essential; S. cerevisiae ortholog is essential 5067 orf19.5067 Predicted ORF in Assemblies 19, 20 and 21 5068 orf19.5068 Predicted ORF in Assemblies 19, 20 and 21 5069 orf19.5069 Predicted ORF in Assemblies 19, 20 and 21 5070 orf19.5070 ############################################################################################################################################################################################################################################################### 5074 orf19.5074 Predicted ORF in Assemblies 19, 20 and 21 5076.1 orf19.5076.1 ORF added to Assembly 21 based on comparative genome analysis 5077 orf19.5077 Predicted ORF in Assemblies 19, 20 and 21; repressed by nitric oxide; possibly spurious ORF (Annotation Working Group prediction) 5078 orf19.5078 Predicted ORF in Assemblies 19, 20 and 21 5079.1 orf19.5079.1 ORF added to Assembly 21 based on comparative genome analysis 5085 orf19.5085 Predicted ORF in Assemblies 19, 20 and 21 5090 orf19.5090 Predicted ORF in Assemblies 19, 20 and 21 5092 orf19.5092 Predicted ORF in Assemblies 19, 20 and 21 5093 orf19.5093 Predicted ORF in Assemblies 19, 20 and 21 5095 orf19.5095 Predicted ORF in Assemblies 19, 20 and 21; caspofungin induced 5099 orf19.5099 Predicted ORF from Assembly 19; removed from Assembly 20 51 orf19.51 Predicted ORF in Assemblies 19, 20 and 21 510 orf19.510 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 5103 orf19.5103 Predicted ORF in Assemblies 19, 20 and 21; clade-associated gene expression 5105 orf19.5105 Predicted ORF in Assemblies 19, 20 and 21 511 orf19.511 Predicted ORF in Assemblies 19, 20 and 21 5114 orf19.5114 Predicted ORF in Assemblies 19, 20 and 21 5114.1 orf19.5114.1 ORF added to Assembly 21 based on comparative genome analysis 5119 orf19.5119 Predicted ORF from Assembly 19 512 orf19.512 Predicted ORF in Assemblies 19, 20 and 21; essential; S. cerevisiae ortholog is essential 5122 orf19.5122 Predicted ORF from Assembly 19; possibly spurious ORF (Annotation Working Group prediction); merged with orf19.1348 in Assembly 20 5123 orf19.5123 Predicted ORF from Assembly 19; merged with orf19.5124 in Assembly 20 5125 orf19.5125 Predicted ORF in Assemblies 19, 20 and 21; expression regulated during planktonic growth 5126 orf19.5126 Predicted ORF in Assemblies 19, 20 and 21 5128 orf19.5128 Predicted ORF from Assembly 19; merged with orf19.5126 in Assembly 20 5129 orf19.5129 Predicted ORF in Assemblies 19, 20 and 21 513 orf19.513 Predicted ORF in Assemblies 19, 20 and 21 5131 orf19.5131 Predicted ORF in Assemblies 19, 20 and 21 5132 orf19.5132 Predicted ORF in Assemblies 19, 20 and 21 5133 orf19.5133 Predicted zinc-finger protein of unknown function 5134 orf19.5134 Predicted ORF in Assemblies 19, 20 and 21 5135 orf19.5135 Predicted ORF from Assembly 19; removed from Assembly 20 5136 orf19.5136 Predicted ORF in Assemblies 19, 20 and 21 5137 orf19.5137 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 5139 orf19.5139 Predicted ORF in Assemblies 19, 20 and 21 5140 orf19.5140 Predicted ORF in Assemblies 19, 20 and 21 5141 orf19.5141 Predicted ORF in Assemblies 19, 20 and 21 5143 orf19.5143 Predicted ORF in Assemblies 19, 20 and 21 5147 orf19.5147 Predicted ORF in Assemblies 19, 20 and 21 515 orf19.515 Predicted ORF in Assemblies 19, 20 and 21 5150 orf19.5150 Predicted ORF from Assembly 19; merged with orf19.5148 in Assembly 20 5151 orf19.5151 Predicted ORF from Assembly 19; merged with orf19.5148 in Assembly 20 5156 orf19.5156 Predicted ORF in Assemblies 19, 20 and 21; has six putative membrane-spanning regions; similar to S. cerevisiae Yjl097p, which is required for growth 5157 orf19.5157 Predicted ORF in Assemblies 19, 20 and 21; hsix putative membrane-spanning regions; similar to S. cerevisiae Yjl097p, which is required for growth 5158 orf19.5158 Protein with slight similarity to a human gene associated with colon cancer and to orf19.5158; regulated by Gcn4p, Cyr1p; induced in response to amino acid starvation (3-aminotriazole treatment); macrophage-induced protein, macrophage-downregulated gene 5159 orf19.5159 Predicted ORF in Assemblies 19, 20 and 21; similarity to S. cerevisiae Ynl191p; similar to amidophosphoribosyl transferases 516 orf19.516 Predicted ORF in Assemblies 19, 20 and 21 5160 orf19.5160 Predicted ORF in Assemblies 19, 20 and 21; similar to S. cerevisiae Sap185p and Sap190p, which are involved in regulation of the cell-cycle phosphatase Sit4p 5161 orf19.5161 Predicted ORF in Assemblies 19, 20 and 21 5165 orf19.5165 Predicted ORF in Assemblies 19, 20 and 21 5168 orf19.5168 Predicted ORF in Assemblies 19, 20 and 21 5169 orf19.5169 Predicted ORF in Assemblies 19, 20 and 21 5170.1 orf19.5170.1 Region annotated in Assembly 21 as a blocked reading frame, based on comparative genome analysis; overlaps orf19.5170, which is an open reading frame 5173 orf19.5173 Predicted ORF from Assembly 19; merged with orf19.5172 in Assembly 20 5175 orf19.5175 Predicted ORF in Assemblies 19, 20 and 21 5177 orf19.5177 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 518 orf19.518 Predicted ORF in Assemblies 19, 20 and 21 5183 orf19.5183 Predicted ORF from Assembly 19; merged with orf19.5182 in Assembly 20 5184 orf19.5184 Predicted ORF in Assemblies 19, 20 and 21 5185 orf19.5185 Predicted ORF from Assembly 19; merged with orf19.5184 in Assembly 20 519 orf19.519 Predicted ORF in Assemblies 19, 20 and 21 5190 orf19.5190 Predicted ORF in Assemblies 19, 20 and 21 5192 orf19.5192 Predicted ORF from Assembly 19; removed from Assembly 20 5193 orf19.5193 Protein similar to oxidoreductases; transcription is upregulated in response to treatment with ciclopirox olamine; upregulation correlates with clinical development of fluconazole resistance; merged with orf19.6837 in Assembly 20 5194 orf19.5194 Predicted ORF from Assembly 19; removed from Assembly 20 5194.1 orf19.5194.1 ORF Predicted by Annotation Working Group; clade-associated gene expression 5195 orf19.5195 Predicted ORF in Assemblies 19, 20 and 21 52 orf19.52 Predicted ORF in Assemblies 19, 20 and 21 520 orf19.520 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 5201 orf19.5201 Predicted ORF in Assemblies 19, 20 and 21 5201.1 orf19.5201.1 ORF added to Assembly 21 based on comparative genome analysis 5202 orf19.5202 Predicted ORF from Assembly 19; removed from Assembly 20 5203 orf19.5203 Predicted ORF in Assemblies 19, 20 and 21 5204 orf19.5204 Predicted ORF in Assemblies 19, 20 and 21 5205 orf19.5205 Predicted ORF in Assemblies 19, 20 and 21 5206 orf19.5206 Predicted ORF in Assemblies 19, 20 and 21 5207 orf19.5207 Predicted ORF in Assemblies 19, 20 and 21 5208 orf19.5208 Predicted ORF from Assembly 19; merged with orf19.5207 in Assembly 20 5209 orf19.5209 Predicted ORF in Assemblies 19, 20 and 21 5210 orf19.5210 Predicted ORF in Assemblies 19, 20 and 21 5212 orf19.5212 Predicted ORF in Assemblies 19, 20 and 21 5213 orf19.5213 Putative protein of unknown function, transcription is upregulated in clinical isolates from HIV+ patients with oral candidiasis; predicted ORF in Assemblies 19, 20 and 21 5216 orf19.5216 Predicted ORF in Assemblies 19, 20 and 21 5218 orf19.5218 Predicted ORF from Assembly 19; merged with orf19.4122 in Assembly 20 522 orf19.522 Predicted ORF in Assemblies 19, 20 and 21 5220 orf19.5220 Predicted ORF in Assemblies 19, 20 and 21; increased expression observed in an ssr1 homozygous null mutant 5221 orf19.5221 Predicted ORF in Assemblies 19, 20 and 21 5222 orf19.5222 Predicted ORF from Assembly 19; merged with orf19.5221 in Assembly 20 5223 orf19.5223 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 5224 orf19.5224 Predicted ORF in Assemblies 19, 20 and 21 5225 orf19.5225 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 5227 orf19.5227 Predicted ORF in Assemblies 19, 20 and 21 5229 orf19.5229 Predicted ORF in Assemblies 19, 20 and 21 5231 orf19.5231 Predicted ORF in Assemblies 19, 20 and 21 5231.2 orf19.5231.2 ORF Predicted by Annotation Working Group 5233 orf19.5233 Predicted ORF in Assemblies 19, 20 and 21 5235 orf19.5235 Protein not essential for viability; protein level decreased in stationary phase cultures 5236 orf19.5236 Predicted ORF in Assemblies 19, 20 and 21; merged with orf19.5236.1 in Assembly 21 5236.1 orf19.5236.1 ORF Predicted by Annotation Working Group; merged with orf19.5236 in Assembly 21 5237 orf19.5237 Predicted ORF in Assemblies 19, 20 and 21 5238 orf19.5238 Predicted ORF in Assemblies 19, 20 and 21 5239 orf19.5239 Predicted ORF in Assemblies 19, 20 and 21; oxidative stress-induced via Cap1p 524 orf19.524 Predicted ORF in Assemblies 19, 20 and 21 5245 orf19.5245 Predicted ORF in Assemblies 19, 20 and 21 5246 orf19.5246 Predicted ORF in Assemblies 19, 20 and 21 5247 orf19.5247 Predicted ORF in Assemblies 19, 20 and 21 5249 orf19.5249 Predicted ORF in Assemblies 19, 20 and 21 5250 orf19.5250 Predicted ORF in Assemblies 19, 20 and 21 5251 orf19.5251 Predicted zinc-finger protein of unknown function; not essential for viability; decreased transcription is observed upon fluphenazine treatment 5252 orf19.5252 Predicted ORF from Assembly 19; removed from Assembly 20 5253 orf19.5253 Predicted ORF in Assemblies 19, 20 and 21 5254 orf19.5254 Predicted ORF in Assemblies 19, 20 and 21; repressed by nitric oxide 5256 orf19.5256 Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium 5258 orf19.5258 Predicted ORF in Assemblies 19, 20 and 21; induced by nitric oxide 5259 orf19.5259 Predicted ORF in Assemblies 19, 20 and 21 5261 orf19.5261 Predicted ORF from Assembly 19; merged with orf19.5260 in Assembly 20 5262 orf19.5262 Predicted ORF in Assemblies 19, 20 and 21 5264 orf19.5264 Predicted ORF in Assemblies 19, 20 and 21 5266 orf19.5266 Predicted ORF in Assemblies 19, 20 and 21 5267 orf19.5267 Putative cell wall protein; downregulated in core caspofungin response; transcription is repressed in response to alpha pheromone in SpiderM medium; transcription repressed in ace2 null mutant 5268 orf19.5268 Predicted ORF in Assemblies 19, 20 and 21 5269 orf19.5269 Predicted ORF in Assemblies 19, 20 and 21 5269.1 orf19.5269.1 ORF added to Assembly 21 based on comparative genome analysis 527 orf19.527 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 5270 orf19.5270 Predicted ORF in Assemblies 19, 20 and 21 5271 orf19.5271 Predicted ORF in Assemblies 19, 20 and 21 5274 orf19.5274 Predicted ORF in Assemblies 19, 20 and 21 5275 orf19.5275 Predicted ORF in Assemblies 19, 20 and 21 5276 orf19.5276 Predicted ORF in Assemblies 19, 20 and 21; induced upon low-level peroxide stress 5277 orf19.5277 Predicted ORF in Assemblies 19, 20 and 21 5278 orf19.5278 Predicted ORF in Assemblies 19, 20 and 21 5279 orf19.5279 Predicted ORF in Assemblies 19, 20 and 21 528 orf19.528 Predicted ORF in Assemblies 19, 20 and 21 5281 orf19.5281 Predicted ORF in Assemblies 19, 20 and 21 5282 orf19.5282 Predicted ORF in Assemblies 19, 20 and 21; decreased expression in hyphae compared to yeast-form cells; regulated by Efg1p and Efh1p; intron in 5'-UTR; transcriptionally activated by Mnl1p under weak acid stress 5283 orf19.5283 Predicted ORF from Assembly 19; merged with orf19.3512 in Assembly 20 5284 orf19.5284 Predicted ORF in Assemblies 19, 20 and 21 5287 orf19.5287 Predicted ORF in Assemblies 19, 20 and 21 5288.1 orf19.5288.1 ORF added to Assembly 21 based on comparative genome analysis 5289 orf19.5289 Predicted ORF in Assemblies 19, 20 and 21 529 orf19.529 Predicted ORF in Assemblies 19, 20 and 21 529.1 orf19.529.1 ORF added to Assembly 21 based on comparative genome analysis 5290 orf19.5290 Transcription is negatively regulated by Sfu1p 5291 orf19.5291 Predicted ORF in Assemblies 19, 20 and 21 5293 orf19.5293 Predicted ORF in Assemblies 19, 20 and 21 5295 orf19.5295 Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium 5296 orf19.5296 Predicted ORF in Assemblies 19, 20 and 21 5297 orf19.5297 Predicted ORF in Assemblies 19, 20 and 21 53 orf19.53 Predicted ORF in Assemblies 19, 20 and 21 530 orf19.530 Protein not essential for viability; possibly spurious ORF (Annotation Working Group prediction) 5300 orf19.5300 Predicted ORF in Assemblies 19, 20 and 21; caspofungin induced 5304 orf19.5304 Predicted ORF in Assemblies 19, 20 and 21 5306 orf19.5306 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 5308 orf19.5308 Predicted ORF in Assemblies 19, 20 and 21; induced by Rgt1p 5311 orf19.5311 Predicted ORF in Assemblies 19, 20 and 21 5312 orf19.5312 Predicted ORF in Assemblies 19, 20 and 21 5313 orf19.5313 Predicted ORF from Assembly 19; merged with orf19.1430 in Assembly 20 5314 orf19.5314 Predicted ORF in Assemblies 19 and 20; possibly spurious ORF (Annotation Working Group prediction); removed from Assembly 21 5319 orf19.5319 Predicted ORF from Assembly 19; merged with orf19.5318 in Assembly 20 5321 orf19.5321 Predicted ORF in Assemblies 19, 20 and 21 5322 orf19.5322 Predicted ORF in Assemblies 19, 20 and 21 5326 orf19.5326 Putative transcription factor with zinc finger DNA-binding motif; possible ortholog of S. cerevisiae Mig2p 5329 orf19.5329 Predicted ORF from Assembly 19; merged with orf19.5328 in Assembly 20 533 orf19.533 Predicted ORF in Assemblies 19, 20 and 21 5333 orf19.5333 Predicted ORF from Assembly 19; merged with orf19.5328 in Assembly 20 5334 orf19.5334 Predicted ORF in Assemblies 19, 20 and 21; transcription regulated upon yeast-hyphal switch 5339 orf19.5339 Predicted ORF in Assemblies 19, 20 and 21 5340 orf19.5340 Predicted ORF in Assemblies 19, 20 and 21 5342 orf19.5342 Predicted ORF in Assemblies 19, 20 and 21; fungal-specific (no human or murine homolog) 5342.2 orf19.5342.2 ORF added to Assembly 21 based on comparative genome analysis 5345 orf19.5345 Predicted ORF in Assemblies 19, 20 and 21; induced by nitric oxide in yhb1 mutant 5346 orf19.5346 Predicted ORF in Assemblies 19, 20 and 21 5350 orf19.5350 Predicted ORF in Assemblies 19, 20 and 21 5352 orf19.5352 Protein not essential for viability 5353 orf19.5353 Predicted ORF in Assemblies 19, 20 and 21 5356 orf19.5356 Predicted ORF in Assemblies 19, 20 and 21; downregulated during core stress response 5358 orf19.5358 Phosphorylated protein of unknown function; predicted ORF in Assemblies 19, 20 and 21 536 orf19.536 Putative ortholog of S. cerevisiae TAF5; has a LisH motif; predicted ORF in Assemblies 19, 20 and 21 5363 orf19.5363 Predicted ORF in Assemblies 19, 20 and 21 5364 orf19.5364 Predicted ORF in Assemblies 19, 20 and 21; intron in 5'-UTR 5365 orf19.5365 Predicted ORF in Assemblies 19, 20 and 21; decreased transcription is observed upon fluphenazine treatment or in an azole-resistant strain that overexpresses CDR1 and CDR2 5365.1 orf19.5365.1 ORF added to Assembly 21 based on comparative genome analysis 5366 orf19.5366 Predicted ORF from Assembly 19; merged with orf19.5365 in Assembly 20 5368 orf19.5368 Predicted ORF in Assemblies 19, 20 and 21 5369 orf19.5369 Predicted ORF in Assemblies 19, 20 and 21 537 orf19.537 Predicted ORF in Assemblies 19, 20 and 21 5370 orf19.5370 Predicted ORF in Assemblies 19, 20 and 21 5371 orf19.5371 Predicted ORF from Assembly 19; removed from Assembly 20 5372 orf19.5372 Predicted ORF from Assembly 19; orf19.5372 and orf19.5373 are similar to the Tca2 (pCal) retrotransposon, which is present in strain hOG1042 as 50 to 100 copies of a linear dsDNA; removed from Assembly 20; transcription is Tbf1p-activated 5373 orf19.5373 Predicted ORF from Assembly 19; orf19.5372 and orf19.5373 are similar to the Tca2 (pCal) retrotransposon, which is present in strain hOG1042 as 50 to 100 copies of a linear dsDNA; clade-associated gene expression; removed from Assembly 20 5375 orf19.5375 Predicted ORF from Assembly 19; removed from Assembly 20 5376 orf19.5376 Predicted ORF in Assemblies 19, 20 and 21 538 orf19.538 Predicted ORF in Assemblies 19, 20 and 21 5381 orf19.5381 Predicted ORF in Assemblies 19, 20 and 21 5382 orf19.5382 ORF Predicted by Annotation Working Group 5390 orf19.5390 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 5391 orf19.5391 Predicted ORF in Assemblies 19, 20 and 21 5393 orf19.5393 Putative cysteine sulfinate decarboxylase; transcription is positively regulated by Tbf1p 5394.1 orf19.5394.1 ORF Predicted by Annotation Working Group 5395 orf19.5395 Predicted ORF in Assemblies 19, 20 and 21 5396 orf19.5396 Predicted ORF from Assembly 19; removed from Assembly 20 5397 orf19.5397 Predicted ORF in Assemblies 19, 20 and 21; decreased transcription is observed upon fluphenazine treatment 540 orf19.540 Predicted ORF in Assemblies 19, 20 and 21 5400 orf19.5400 ORF Predicted by Annotation Working Group; merged with orf19.5399 in Assembly 20 5401 orf19.5401 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to toxic ergosterol analog; decreased transcription is observed upon fluphenazine treatment 5402 orf19.5402 ORF Predicted by Annotation Working Group 5406 orf19.5406 Predicted ORF in Assemblies 19, 20 and 21 5408 orf19.5408 Predicted ORF in Assemblies 19, 20 and 21 5409 orf19.5409 Predicted ORF in Assemblies 19, 20 and 21 541 orf19.541 Predicted ORF in Assemblies 19, 20 and 21 5410 orf19.5410 Predicted ORF in Assemblies 19, 20 and 21 5411 orf19.5411 Predicted ORF in Assemblies 19, 20 and 21 5412 orf19.5412 Predicted ORF in Assemblies 19, 20 and 21 5413 orf19.5413 Predicted ORF in Assemblies 19, 20 and 21 5418 orf19.5418 Predicted ORF in Assemblies 19, 20 and 21 542.2 orf19.542.2 ORF Predicted by Annotation Working Group 5420 orf19.5420 Predicted ORF in Assemblies 19, 20 and 21 5422 orf19.5422 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 5424 orf19.5424 ORF Predicted by Annotation Working Group 5425 orf19.5425 Predicted ORF in Assemblies 19, 20 and 21 5426 orf19.5426 Putative patatin-like phospholipase; macrophage-regulated gene; fungal-specific (no human or murine homolog) 5428 orf19.5428 Predicted ORF in Assemblies 19, 20 and 21; clade-associated gene expression 5429 orf19.5429 Predicted ORF in Assemblies 19, 20 and 21 5431 orf19.5431 Predicted ORF in Assemblies 19, 20 and 21 5433 orf19.5433 Predicted ORF in Assemblies 19, 20 and 21 5438 orf19.5438 Predicted ORF in Assemblies 19, 20 and 21 5439 orf19.5439 Predicted ORF in Assemblies 19, 20 and 21 544 orf19.544 Predicted ORF in Assemblies 19, 20 and 21 5442 orf19.5442 Predicted ORF in Assemblies 19, 20 and 21 5443 orf19.5443 Putative kynurenine 3-monooxygenase, involved in NAD biosynthesis; transposon mutation affects filamentous growth 5444 orf19.5444 Predicted ORF in Assemblies 19, 20 and 21 5446 orf19.5446 Putative protein of unknown function, transcription is upregulated in clinical isolates from HIV+ patients with oral candidiasis; regulated by Ssn6p; ORF Predicted by Annotation Working Group 5449 orf19.5449 Predicted ORF in Assemblies 19, 20 and 21 5450 orf19.5450 Predicted ORF in Assemblies 19, 20 and 21; protein detected by mass spec in exponential and stationary phase cultures 5451 orf19.5451 ORF Predicted by Annotation Working Group 5455 orf19.5455 Predicted ORF in Assemblies 19, 20 and 21 5457 orf19.5457 Predicted ORF in Assemblies 19, 20 and 21 5459 orf19.5459 Putative protein of unknown function, transcription is upregulated in an RHE model of oral candidiasis and in clinical isolates from HIV+ patients with oral candidiasis; predicted ORF in Assemblies 19, 20 and 21 5461 orf19.5461 ORF Predicted by Annotation Working Group; possibly spurious ORF (Annotation Working Group prediction) 5462 orf19.5462 ORF Predicted by Annotation Working Group; possibly spurious ORF (Annotation Working Group prediction) 5463 orf19.5463 Predicted ORF in Assemblies 19, 20 and 21 5464 orf19.5464 ORF Predicted by Annotation Working Group 5465 orf19.5465 Predicted ORF in Assemblies 19, 20 and 21 5468 orf19.5468 Predicted ORF from Assembly 19; removed from Assembly 20 5469 orf19.5469 Predicted ORF in Assemblies 19, 20 and 21; shows colony morphology-related gene regulation by Ssn6p 547 orf19.547 Predicted ORF in Assemblies 19, 20 and 21 5472 orf19.5472 ORF Predicted by Annotation Working Group 5474 orf19.5474 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction); transcriptionally activated by Mnl1p under weak acid stress 5475 orf19.5475 ORF Predicted by Annotation Working Group 5477 orf19.5477 Putative sulfite reductase; greater mRNA abundance observed in cyr1 or efg1 homozygous null mutant hyphae; merged with orf19.4099 in Assembly 20 5483 orf19.5483 Predicted ORF in Assemblies 19, 20 and 21 5486 orf19.5486 Putative protein of unknown function; heterozygous null mutant exhibits hypersensitivity to parnafungin and cordycepin in the C. albicans fitness test; predicted ORF in Assemblies 19, 20 and 21 5488 orf19.5488 Predicted ORF in Assemblies 19, 20 and 21 5489 orf19.5489 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction); merged with orf19.5490 in Assembly 21 549 orf19.549 Predicted ORF in Assemblies 19, 20 and 21 5490 orf19.5490 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction); merged with orf19.5489 in Assembly 21 5491 orf19.5491 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 5492 orf19.5492 Predicted ORF in Assemblies 19, 20 and 21 5494 orf19.5494 Predicted ORF from Assembly 19; removed from Assembly 20 5495 orf19.5495 Protein not essential for viability; transcription is induced in response to alpha pheromone in SpiderM medium 5499 orf19.5499 Predicted ORF in Assemblies 19, 20 and 21 55 orf19.55 Predicted ORF in Assemblies 19, 20 and 21 5502 orf19.5502 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 5503 orf19.5503 Putative protein of unknown function, transcription is upregulated in clinical isolates from HIV+ patients with oral candidiasis; predicted ORF in Assemblies 19, 20 and 21 5504 orf19.5504 Predicted ORF in Assemblies 19, 20 and 21 5508 orf19.5508 Predicted ORF in Assemblies 19, 20 and 21 5509 orf19.5509 Predicted ORF from Assembly 19; merged with orf19.6703 in Assembly 20 5509.2 orf19.5509.2 ORF Predicted by Annotation Working Group; removed from Assembly 20 551 orf19.551 Predicted ORF in Assemblies 19, 20 and 21 5510 orf19.5510 Predicted ORF in Assemblies 19, 20 and 21 5512 orf19.5512 Predicted ORF from Assembly 19; removed from Assembly 20 5513 orf19.5513 Predicted ORF in Assemblies 19, 20 and 21 5514 orf19.5514 Predicted ORF in Assemblies 19, 20 and 21 5515 orf19.5515 Predicted ORF in Assemblies 19, 20 and 21 5516 orf19.5516 Predicted ORF in Assemblies 19, 20 and 21 5517 orf19.5517 Similar to alcohol dehydrogenases; increased transcription is observed upon benomyl treatment; induced by nitric oxide; induced in core stress response; oxidative stress-induced via Cap1p 5518 orf19.5518 Predicted ORF in Assemblies 19, 20 and 21 552 orf19.552 Predicted ORF in Assemblies 19, 20 and 21 5522 orf19.5522 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 5523 orf19.5523 Predicted ORF in Assemblies 19, 20 and 21 5524 orf19.5524 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 5525 orf19.5525 Protein abundance is affected by URA3 expression in the CAI-4 strain background; regulated by Efg1p and Efh1p; repressed by Rgt1p; protein detected by mass spec in exponential and stationary phase cultures 5527 orf19.5527 Predicted ORF in Assemblies 19, 20 and 21; similar to S. cerevisiae Ymr285p and Yml118p; gene transcribed divergently from SEC20 553 orf19.553 Predicted membrane transporter, member of the drug:proton antiporter (12 spanner) (DHA1) family, major facilitator superfamily (MFS) 5532 orf19.5532 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 5533 orf19.5533 Predicted ORF in Assemblies 19, 20 and 21 5534 orf19.5534 Predicted ORF in Assemblies 19, 20 and 21 5535 orf19.5535 Predicted membrane transporter, member of the anion:cation symporter (ACS) family, major facilitator superfamily (MFS) 5536 orf19.5536 Predicted ORF in Assemblies 19, 20 and 21 5537 orf19.5537 Predicted ORF in Assemblies 19, 20 and 21 5539 orf19.5539 Predicted ORF in Assemblies 19, 20 and 21 5541 orf19.5541 Predicted ORF in Assemblies 19, 20 and 21; similar to S. pombe Nrd1p; transcription is induced upon induction of hyphal growth; regulated by Cph1p, Efg1p, Cph2p; low-level expression; alkaline upregulated; fungal-specific (no human or murine homolog) 5543 orf19.5543 Predicted ORF in Assemblies 19, 20 and 21 5546 orf19.5546 Predicted ORF from Assembly 19; merged with orf19.5544 in Assembly 20; protein level decreased in stationary phase cultures 5547 orf19.5547 Predicted ORF in Assemblies 19, 20 and 21 5548 orf19.5548 Putative transcription factor with zinc cluster DNA-binding motif; has similarity to S. cerevisiae Lys14p, which is a transcription factor involved in the regulation of lysine biosynthesis genes 5549 orf19.5549 Predicted ORF in Assemblies 19, 20 and 21 555 orf19.555 Protein similar to S. cerevisiae Cis3p, which has a role cell-wall-related processes; predicted Kex2p substrate 5552 orf19.5552 Predicted ORF in Assemblies 19, 20 and 21 5553 orf19.5553 Predicted ORF in Assemblies 19, 20 and 21 5555 orf19.5555 Predicted ORF in Assemblies 19, 20 and 21 5556 orf19.5556 Predicted ORF in Assemblies 19, 20 and 21 556 orf19.556 Predicted ORF in Assemblies 19, 20 and 21; regulated by Ssn6p; possibly spurious ORF (Annotation Working Group prediction) 5560 orf19.5560 Predicted ORF from Assembly 19; removed from Assembly 20 5564 orf19.5564 Predicted ORF in Assemblies 19, 20 and 21; was merged with orf19.5563 by Annotation Working Group and subsequently reinstated; similar to RNH1 (see Locus History) 5565 orf19.5565 Putative 3-hydroxyisobutyrate dehydrogenase 5566 orf19.5566 Predicted ORF in Assemblies 19, 20 and 21 5569 orf19.5569 Predicted ORF in Assemblies 19, 20 and 21 557 orf19.557 Predicted ORF in Assemblies 19, 20 and 21 5571 orf19.5571 Protein not essential for viability; merged with orf19.5569 in Assembly 20 5572 orf19.5572 Predicted ORF in Assemblies 19, 20 and 21 5573 orf19.5573 Predicted ORF in Assemblies 19, 20 and 21; decreased expression observed in an ssr1 homozygous null mutant 5574 orf19.5574 Predicted ORF in Assemblies 19, 20 and 21 5575 orf19.5575 Predicted ORF in Assemblies 19, 20 and 21 5576 orf19.5576 Protein similar to S. cerevisiae Ydr531wp; transposon mutation affects filamentous growth; downregulated in core stress response 5577 orf19.5577 Predicted ORF from Assembly 19; merged with orf19.5576 in Assembly 20 5578 orf19.5578 Predicted ORF in Assemblies 19, 20 and 21 5579 orf19.5579 Predicted ORF in Assemblies 19, 20 and 21 5580 orf19.5580 Predicted ORF in Assemblies 19, 20 and 21 5586 orf19.5586 Predicted ORF in Assemblies 19, 20 and 21 5587 orf19.5587 Putative protein of unknown function, transcription is upregulated in clinical isolates from HIV+ patients with oral candidiasis; predicted ORF in Assemblies 19, 20 and 21 5589 orf19.5589 Predicted ORF in Assemblies 19, 20 and 21 5592 orf19.5592 Predicted ORF in Assemblies 19, 20 and 21 5593 orf19.5593 Predicted ORF from Assembly 19; merged with orf19.5592 in Assembly 20 5595 orf19.5595 Predicted ORF in Assemblies 19, 20 and 21 5596 orf19.5596 Predicted ORF in Assemblies 19, 20 and 21 5597.1 orf19.5597.1 ORF added to Assembly 21 based on comparative genome analysis 5598 orf19.5598 Predicted ORF from Assembly 19; merged with orf19.5597 in Assembly 20 5600 orf19.5600 Predicted ORF from Assembly 19; orf19.5599 and orf19.5600 may be a single ORF; merged with orf19.5599 in Assembly 20 5601 orf19.5601 Predicted ORF in Assemblies 19, 20 and 21 5605 orf19.5605 Predicted ORF in Assemblies 19, 20 and 21; fungal-specific (no human or murine homolog) 5606 orf19.5606 Predicted ORF in Assemblies 19, 20 and 21 5607 orf19.5607 Predicted ORF in Assemblies 19, 20 and 21 5608 orf19.5608 Predicted ORF in Assemblies 19, 20 and 21 5609 orf19.5609 Predicted ORF in Assemblies 19, 20 and 21 561 orf19.561 Predicted ORF from Assembly 19; removed from Assembly 20 5611 orf19.5611 Predicted ORF in Assemblies 19, 20 and 21 5614 orf19.5614 Predicted ORF in Assemblies 19, 20 and 21 5616 orf19.5616 Predicted ORF in Assemblies 19, 20 and 21 5617 orf19.5617 Predicted ORF in Assemblies 19, 20 and 21 5618 orf19.5618 Predicted ORF in Assemblies 19, 20 and 21 5619 orf19.5619 Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium 5620 orf19.5620 Predicted ORF in Assemblies 19, 20 and 21; regulated by Gcn4p; induced in response to amino acid starvation (3-aminotriazole treatment); increased transcription is observed upon benomyl treatment or in an azole-resistant strain that overexpresses MDR1 5621 orf19.5621 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to amphotericin B 5624 orf19.5624 Predicted ORF from Assembly 19; merged with orf19.5623 in Assembly 20 5625 orf19.5625 Predicted ORF in Assemblies 19, 20 and 21 5626 orf19.5626 Predicted ORF in Assemblies 19, 20 and 21; Plc1p-regulated; transcriptionally activated by Mnl1p under weak acid stress 5627 orf19.5627 Predicted ORF in Assemblies 19, 20 and 21 5628 orf19.5628 Predicted ORF in Assemblies 19, 20 and 21 5631 orf19.5631 Predicted ORF from Assembly 19; possibly spurious ORF (Annotation Working Group prediction); merged with orf19.5701 in Assembly 20 5632 orf19.5632 Predicted ORF from Assembly 19; merged with orf19.377 in Assembly 20 5633 orf19.5633 Predicted ORF in Assemblies 19, 20 and 21 5642 orf19.5642 Predicted ORF in Assemblies 19, 20 and 21; shows colony morphology-related gene regulation by Ssn6p; greater mRNA abundance observed in a cyr1 homozygous null mutant than in wild type 5644 orf19.5644 Predicted ORF in Assemblies 19, 20 and 21 5646 orf19.5646 Predicted ORF in Assemblies 19, 20 and 21 5648 orf19.5648 Predicted ORF in Assemblies 19, 20 and 21 5649 orf19.5649 ORF Predicted by Annotation Working Group 5651 orf19.5651 Predicted ORF in Assemblies 19, 20 and 21 5654 orf19.5654 Predicted ORF in Assemblies 19, 20 and 21 5655 orf19.5655 Predicted ORF in Assemblies 19, 20 and 21 5656 orf19.5656 Predicted ORF from Assembly 19; merged with orf19.5655 in Assembly 20 5659 orf19.5659 Predicted ORF from Assembly 19; removed from Assembly 20 566 orf19.566 Predicted ORF from Assembly 19; shows colony morphology-related gene regulation by Ssn6p; clade-associated gene expression; removed from Assembly 20 5660 orf19.5660 Predicted ORF in Assemblies 19, 20 and 21 5660.1 orf19.5660.1 ORF Predicted by Annotation Working Group 5663 orf19.5663 Protein of unknown function; null mutation confers resistance to azoles and terbinafine; predicted ORF in Assemblies 19, 20 and 21 5665 orf19.5665 Predicted ORF in Assemblies 19, 20 and 21 5666 orf19.5666 Predicted ORF in Assemblies 19, 20 and 21 5669 orf19.5669 Predicted ORF in Assemblies 19, 20 and 21 5671 orf19.5671 Predicted ORF in Assemblies 19, 20 and 21 5675 orf19.5675 Predicted ORF in Assemblies 19, 20 and 21 5676 orf19.5676 Predicted ORF in Assemblies 19, 20 and 21 5678 orf19.5678 Predicted ORF in Assemblies 19, 20 and 21 5679 orf19.5679 Predicted ORF from Assembly 19; merged with orf19.980 in Assembly 20 5680 orf19.5680 Predicted ORF in Assemblies 19, 20 and 21 5681 orf19.5681 Predicted ORF in Assemblies 19, 20 and 21 5682 orf19.5682 Predicted ORF in Assemblies 19, 20 and 21 5683 orf19.5683 Predicted ORF in Assemblies 19, 20 and 21; clade-associated gene expression 5684 orf19.5684 Predicted ORF in Assemblies 19, 20 and 21 5684.1 orf19.5684.1 ORF added to Assembly 21 based on comparative genome analysis 5686 orf19.5686 Predicted ORF in Assemblies 19, 20 and 21 5688 orf19.5688 Predicted ORF from Assembly 19; removed from Assembly 20; subsequently reinstated in Assembly 21 based on comparative genome analysis 5689 orf19.5689 Predicted ORF in Assemblies 19, 20 and 21 5692 orf19.5692 Predicted ORF in Assemblies 19, 20 and 21 5693 orf19.5693 Predicted ORF in Assemblies 19, 20 and 21 5694 orf19.5694 Predicted ORF from Assembly 19; removed from Assembly 20 5698 orf19.5698 Putative ribosomal protein, transcription is upregulated in clinical isolates from HIV+ patients with oral candidiasis; predicted ORF in Assemblies 19, 20 and 21 5701 orf19.5701 Predicted ORF in Assemblies 19, 20 and 21 5702 orf19.5702 Predicted ORF in Assemblies 19, 20 and 21 5704 orf19.5704 Predicted ORF in Assemblies 19, 20 and 21 5710 orf19.5710 Predicted ORF in Assemblies 19, 20 and 21 5711 orf19.5711 Predicted ORF in Assemblies 19, 20 and 21 5717 orf19.5717 Predicted ORF in Assemblies 19, 20 and 21 5718 orf19.5718 Predicted ORF in Assemblies 19, 20 and 21; merged with orf19.1019 in Assembly 21 5719 orf19.5719 Predicted ORF from Assembly 19; removed from Assembly 20; subsequently reinstated in Assembly 21 and merged with orf19.1020 based on comparative genome analysis 5720 orf19.5720 Predicted membrane transporter, member of the monocarboxylate porter (MCP) family, major facilitator superfamily (MFS); ketoconazole or caspofungin repressed 5722 orf19.5722 Predicted ORF in Assemblies 19, 20 and 21 5724 orf19.5724 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 5725 orf19.5725 Predicted ORF in Assemblies 19, 20 and 21 5726 orf19.5726 Predicted ORF from Assembly 19; merged with orf19.5725 in Assembly 20 5727 orf19.5727 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 5728 orf19.5728 Predicted ORF in Assemblies 19, 20 and 21 5730 orf19.5730 Predicted ORF in Assemblies 19, 20 and 21; clade-associated gene expression 5733 orf19.5733 Predicted ORF from Assembly 19; merged with orf19.5732 in Assembly 20 5734 orf19.5734 Putative protein of unknown function; heterozygous null mutant exhibits resistance to parnafungin and cordycepin in the C. albicans fitness test; predicted ORF in Assemblies 19, 20 and 21 5735.3 orf19.5735.3 ORF Predicted by Annotation Working Group 5744 orf19.5744 Predicted ORF from Assembly 19; removed from Assembly 20 5747 orf19.5747 Predicted ORF in Assemblies 19, 20 and 21 5748 orf19.5748 Predicted ORF in Assemblies 19, 20 and 21 5752 orf19.5752 Predicted ORF in Assemblies 19, 20 and 21 5754 orf19.5754 Predicted ORF in Assemblies 19, 20 and 21; fluconazole-induced 5755 orf19.5755 Predicted ORF in Assemblies 19, 20 and 21 5757 orf19.5757 Predicted ORF in Assemblies 19, 20 and 21 5761 orf19.5761 Protein not essential for viability; transcription is alkaline upregulated; merged with orf19.5760 in Assembly 20 5763 orf19.5763 Predicted ORF in Assemblies 19, 20 and 21 5765 orf19.5765 Predicted ORF in Assemblies 19, 20 and 21 5767 orf19.5767 Predicted ORF in Assemblies 19, 20 and 21 5769 orf19.5769 Predicted ORF from Assembly 19; merged with orf19.5768 in Assembly 20 577 orf19.577 Predicted ORF in Assemblies 19, 20 and 21 5772 orf19.5772 Predicted ORF in Assemblies 19, 20 and 21 5773 orf19.5773 Predicted ORF in Assemblies 19, 20 and 21; Hog1p-induced; clade-associated gene expression; protein detected by mass spec in exponential and stationary phase cultures 5775 orf19.5775 Predicted ORF in Assemblies 19, 20 and 21; member of a family encoded by FGR6-related genes in the RB2 repeat sequence 5775.3 orf19.5775.3 ORF Predicted by Annotation Working Group; removed from Assembly 21 5777 orf19.5777 Predicted ORF in Assemblies 19, 20 and 21; induced upon biofilm formation 578 orf19.578 Predicted ORF in Assemblies 19, 20 and 21 5780 orf19.5780 Predicted ORF in Assemblies 19, 20 and 21 5782 orf19.5782 Predicted ORF in Assemblies 19, 20 and 21 5783 orf19.5783 Predicted ORF in Assemblies 19, 20 and 21 5784 orf19.5784 Predicted ORF in Assemblies 19, 20 and 21 5785 orf19.5785 Predicted ORF in Assemblies 19, 20 and 21; greater mRNA abundance observed in a cyr1 or ras1 homozygous null mutant than in wild type; induced by nitric oxide; possibly spurious ORF (Annotation Working Group prediction) 5799 orf19.5799 Predicted ORF in Assemblies 19, 20 and 21 580 orf19.580 Protein not essential for viability 5800 orf19.5800 Predicted ORF from Assembly 19; removed from Assembly 20 5802 orf19.5802 Predicted ORF in Assemblies 19, 20 and 21 5808 orf19.5808 Predicted ORF in Assemblies 19, 20 and 21 5809 orf19.5809 Putative arylformamidase, enzyme of the NAD biosynthesis pathway; Gcn4p-regulated 581 orf19.581 Putative protein of unknown function, transcription is upregulated in an RHE model of oral candidiasis; predicted ORF in Assemblies 19, 20 and 21 5812 orf19.5812 Predicted ORF in Assemblies 19, 20 and 21 5813 orf19.5813 Predicted ORF in Assemblies 19, 20 and 21 5814 orf19.5814 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 5817 orf19.5817 Predicted ORF in Assemblies 19, 20 and 21 5819 orf19.5819 Predicted ORF from Assembly 19; removed from Assembly 20 5821 orf19.5821 Predicted ORF in Assemblies 19, 20 and 21 5824 orf19.5824 Predicted ORF in Assemblies 19, 20 and 21 5825 orf19.5825 Predicted ORF in Assemblies 19, 20 and 21 5825.1 orf19.5825.1 ORF Predicted by Annotation Working Group 5826 orf19.5826 Predicted ORF in Assemblies 19, 20 and 21 5828 orf19.5828 Predicted ORF in Assemblies 19, 20 and 21 583 orf19.583 Putative indoleamine 2,3-dioxygenase (IDO); IDO is the rate-limiting enzyme of tryptophan catabolism via kynurenine pathway; enzyme inhibition by 1-methyl-D,L-tryptophan causes increased hyphal growth; expressed in yeast-form cells and hyphae 5830 orf19.5830 Protein similar to S. cerevisiae Hsp70p; predicted Kex2p substrate 5831 orf19.5831 Predicted ORF in Assemblies 19, 20 and 21 5833 orf19.5833 Predicted ORF in Assemblies 19, 20 and 21 5834 orf19.5834 Predicted ORF in Assemblies 19, 20 and 21 5835 orf19.5835 Predicted ORF in Assemblies 19, 20 and 21 5837 orf19.5837 Predicted ORF in Assemblies 19, 20 and 21 5838 orf19.5838 Predicted ORF in Assemblies 19, 20 and 21 584 orf19.584 Predicted ORF in Assemblies 19, 20 and 21 5840 orf19.5840 Predicted ORF in Assemblies 19, 20 and 21 5841 orf19.5841 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 5842 orf19.5842 Predicted ORF in Assemblies 19, 20 and 21 5842.1 orf19.5842.1 Predicted ORF in Assemblies 19 and 20; removed from Assembly 21 5843 orf19.5843 Predicted ORF in Assemblies 19, 20 and 21; Plc1p-regulated; greater mRNA abundance observed in a cyr1 homozygous null mutant than in wild type; possibly spurious ORF (Annotation Working Group prediction) 5844 orf19.5844 Predicted ORF in Assemblies 19, 20 and 21 5846 orf19.5846 Predicted ORF in Assemblies 19, 20 and 21 5847 orf19.5847 Predicted ORF in Assemblies 19, 20 and 21 5848 orf19.5848 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 585 orf19.585 Predicted ORF in Assemblies 19, 20 and 21 5852 orf19.5852 Predicted ORF in Assemblies 19, 20 and 21 5853 orf19.5853 Predicted ORF from Assembly 19; merged with orf19.3519 in Assembly 20 5854.1 orf19.5854.1 ORF Predicted by Annotation Working Group 5856 orf19.5856 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 5857 orf19.5857 Predicted ORF in Assemblies 19, 20 and 21 5860 orf19.5860 Predicted ORF from Assembly 19; removed from Assembly 20; subsequently reinstated in Assembly 21 based on comparative genome analysis 5861.1 orf19.5861.1 ORF added to Assembly 21 based on comparative genome analysis 5862 orf19.5862 Protein described as related to arginases; downregulated upon adherence to polystyrene; regulated by Gcn2p and Gcn4p 5863 orf19.5863 Predicted ORF in Assemblies 19, 20 and 21 5865 orf19.5865 Predicted ORF in Assemblies 19, 20 and 21 5866 orf19.5866 Protein not essential for viability 5869 orf19.5869 Predicted ORF in Assemblies 19, 20 and 21 587 orf19.587 Predicted ORF in Assemblies 19, 20 and 21 5871 orf19.5871 Predicted ORF in Assemblies 19, 20 and 21 5872 orf19.5872 Predicted ORF from Assembly 19; merged with orf19.5871 in Assembly 20 5874 orf19.5874 Predicted ORF in Assemblies 19, 20 and 21 5876 orf19.5876 Predicted ORF in Assemblies 19, 20 and 21; greater mRNA abundance observed in a cyr1 homozygous null mutant than in wild type; transcription is induced in response to alpha pheromone in SpiderM medium 5879 orf19.5879 Predicted ORF in Assemblies 19, 20 and 21 588 orf19.588 Predicted ORF in Assemblies 19, 20 and 21 5880 orf19.5880 Predicted ORF in Assemblies 19, 20 and 21 5881 orf19.5881 Predicted ORF from Assembly 19; merged with orf19.5880 in Assembly 20 5884 orf19.5884 Predicted ORF in Assemblies 19, 20 and 21; decreased transcription is observed upon benomyl treatment or in an azole-resistant strain that overexpresses MDR1 5885 orf19.5885 Predicted ORF in Assemblies 19, 20 and 21; flucytosine induced 5889 orf19.5889 Predicted ORF from Assembly 19; merged with orf19.5892 in Assembly 20 5890 orf19.5890 Predicted ORF in Assemblies 19, 20 and 21 5891 orf19.5891 Predicted ORF from Assembly 19; merged with orf19.5892 in Assembly 20 5892 orf19.5892 Predicted ORF in Assemblies 19, 20 and 21 5894 orf19.5894 Predicted ORF in Assemblies 19, 20 and 21 5895 orf19.5895 Predicted ORF from Assembly 19; merged with orf19.5894 in Assembly 20 5896 orf19.5896 Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium 5897 orf19.5897 Predicted ORF in Assemblies 19, 20 and 21 590 orf19.590 Predicted ORF in Assemblies 19, 20 and 21; decreased expression observed in an ssr1 homozygous null mutant; protein detected by mass spec in exponential and stationary phase cultures 5905 orf19.5905 Predicted ORF in Assemblies 19, 20 and 21; induced upon biofilm formation 5910 orf19.5910 Predicted ORF in Assemblies 19, 20 and 21; induced upon low-level peroxide stress 5915 orf19.5915 Predicted ORF in Assemblies 19, 20 and 21 5916 orf19.5916 Predicted ORF from Assembly 19; merged with orf19.5915 in Assembly 20 5917.3 orf19.5917.3 ORF Predicted by Annotation Working Group 5918 orf19.5918 Predicted ORF in Assemblies 19, 20 and 21 592 orf19.592 Predicted ORF in Assemblies 19, 20 and 21 5920 orf19.5920 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 5921 orf19.5921 Predicted ORF in Assemblies 19, 20 and 21 5924 orf19.5924 Predicted zinc-finger protein of unknown function 5925 orf19.5925 Predicted ORF in Assemblies 19, 20 and 21 5929 orf19.5929 Putative protein of unknown function, transcription is positively regulated by Tbf1p; predicted ORF in Assemblies 19, 20 and 21 5930 orf19.5930 Predicted ORF in Assemblies 19, 20 and 21 5931 orf19.5931 Predicted ORF in Assemblies 19, 20 and 21 5932 orf19.5932 Predicted ORF in Assemblies 19, 20 and 21; fungal-specific (no human or murine homolog) 5933 orf19.5933 Predicted ORF in Assemblies 19, 20 and 21; increased transcription is observed upon benomyl treatment; possibly spurious ORF (Annotation Working Group prediction) 5934 orf19.5934 Predicted ORF in Assemblies 19, 20 and 21 5935 orf19.5935 Predicted ORF in Assemblies 19, 20 and 21 5940 orf19.5940 Predicted zinc-finger protein of unknown function 5941 orf19.5941 Predicted ORF in Assemblies 19, 20 and 21 5942 orf19.5942 Protein described as a zinc finger protein similar to S. cerevisiae Itt1p; downregulated upon adherence to polystyrene 5943 orf19.5943 Predicted ORF in Assemblies 19, 20 and 21 5943.1 orf19.5943.1 Putative protein of unknown function, transcription is upregulated in an RHE model of oral candidiasis; ORF Predicted by Annotation Working Group 5951 orf19.5951 Predicted ORF from Assembly 19; merged with orf19.5949 in Assembly 20 5952 orf19.5952 Predicted ORF in Assemblies 19, 20 and 21; induced by nitric oxide in yhb1 null mutant 5953 orf19.5953 Predicted ORF in Assemblies 19, 20 and 21 5954 orf19.5954 Predicted ORF in Assemblies 19, 20 and 21 5956 orf19.5956 Predicted ORF in Assemblies 19, 20 and 21 596 orf19.596 Predicted ORF from Assembly 19; removed from Assembly 20 596.2 orf19.596.2 Predicted ORF in Assembly 20 and 21; gene has intron 5960 orf19.5960 Predicted ORF in Assemblies 19, 20 and 21 5961 orf19.5961 Predicted ORF in Assemblies 19, 20 and 21; described as similar to S. cerevisiae Nas6p proteasome component; induced upon adherence to polystyrene; regulated by Gcn2p and Gcn4p 5963 orf19.5963 Predicted ORF in Assemblies 19, 20 and 21 5965 orf19.5965 Predicted ORF in Assemblies 19, 20 and 21 5966 orf19.5966 Predicted ORF in Assemblies 19, 20 and 21 597 orf19.597 Predicted ORF in Assemblies 19, 20 and 21; Gcn4p-regulated 5970 orf19.5970 Protein described as a DNA repair helicase; transcriptionally induced by interaction with macrophage; fungal-specific (no human or murine homolog) 5971 orf19.5971 Predicted ORF in Assemblies 19, 20 and 21 5973 orf19.5973 Predicted ORF in Assemblies 19, 20 and 21 5975 orf19.5975 Putative transcription factor with zinc finger DNA-binding motif; fluconazole-downregulated; expression regulated during planktonic growth; increased expression observed in an ssr1 homozygous null mutant 5976 orf19.5976 Predicted ORF in Assemblies 19, 20 and 21; decreased transcription is observed upon fluphenazine treatment, in azole-resistant strains that overexpress CDR1 and CDR2 or MDR1 5978 orf19.5978 Predicted ORF in Assemblies 19, 20 and 21 598 orf19.598 Predicted ORF in Assemblies 19, 20 and 21 5980 orf19.5980 Predicted ORF in Assemblies 19, 20 and 21 5984 orf19.5984 Predicted ORF in Assemblies 19, 20 and 21 5985 orf19.5985 Predicted ORF in Assemblies 19, 20 and 21 5987 orf19.5987 Predicted ORF in Assemblies 19, 20 and 21 5989 orf19.5989 Predicted ORF in Assemblies 19, 20 and 21 599 orf19.599 Predicted ORF in Assemblies 19, 20 and 21 5991 orf19.5991 Predicted ORF in Assemblies 19, 20 and 21 5993 orf19.5993 Predicted ORF from Assembly 19; removed from Assembly 20 6 orf19.6 Predicted ORF from Assembly 19; removed from Assembly 20 60 orf19.60 Predicted ORF from Assembly 19; merged with orf19.4064 in Assembly 20 6003 orf19.6003 Predicted ORF in Assemblies 19, 20 and 21 6004 orf19.6004 Predicted ORF from Assembly 19; removed from Assembly 20 6007 orf19.6007 Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins 6008 orf19.6008 Predicted ORF in Assemblies 19, 20 and 21; transcription is repressed in response to alpha pheromone in SpiderM medium 6008.3 orf19.6008.3 ORF Predicted by Annotation Working Group 6008.4 orf19.6008.4 Predicted ORF in Assembly 20 and 21 6012 orf19.6012 Predicted ORF in Assemblies 19, 20 and 21 6013 orf19.6013 Predicted ORF in Assemblies 19, 20 and 21 6016 orf19.6016 Predicted ORF in Assemblies 19, 20 and 21 6017 orf19.6017 Predicted ORF in Assemblies 19, 20 and 21 6019 orf19.6019 Predicted ORF from Assembly 19; merged with orf19.6018 in Assembly 20 602 orf19.602 Predicted ORF from Assembly 19; merged with orf19.600 in Assembly 20 6020 orf19.6020 Predicted ORF in Assemblies 19, 20 and 21 6022 orf19.6022 Predicted ORF in Assemblies 19, 20 and 21; downregulated during core stress response 6023 orf19.6023 Predicted ORF in Assemblies 19, 20 and 21 6024 orf19.6024 Predicted ORF in Assemblies 19, 20 and 21 6025 orf19.6025 Predicted ORF in Assemblies 19, 20 and 21 6027 orf19.6027 Predicted ORF in Assemblies 19, 20 and 21 6030 orf19.6030 Predicted ORF in Assemblies 19, 20 and 21 6031 orf19.6031 Predicted ORF in Assemblies 19, 20 and 21 6035 orf19.6035 Predicted ORF in Assemblies 19, 20 and 21; repressed by nitric oxide 6038 orf19.6038 Predicted zinc-finger protein of unknown function; has similarity to S. cerevisiae Uga3p, which is a transcription factor involved in the regulation of gamma-aminobutyrate metabolism genes 6039 orf19.6039 Predicted ORF in Assemblies 19, 20 and 21 604 orf19.604 Predicted ORF in Assemblies 19, 20 and 21 6043 orf19.6043 Predicted ORF in Assemblies 19, 20 and 21 6045 orf19.6045 Predicted ORF in Assemblies 19, 20 and 21 6048 orf19.6048 Predicted ORF in Assemblies 19, 20 and 21 6049 orf19.6049 Predicted ORF in Assemblies 19, 20 and 21 605 orf19.605 Predicted ORF in Assemblies 19, 20 and 21 6054 orf19.6054 Predicted ORF in Assemblies 19, 20 and 21; decreased transcription is observed in an azole-resistant strain that overexpresses MDR1 6055 orf19.6055 Predicted ORF in Assemblies 19, 20 and 21 6056 orf19.6056 Predicted ORF in Assemblies 19, 20 and 21 6057 orf19.6057 Predicted ORF in Assemblies 19, 20 and 21 606 orf19.606 Predicted ORF in Assemblies 19, 20 and 21 6061 orf19.6061 Predicted ORF in Assemblies 19, 20 and 21 6062 orf19.6062 Predicted ORF in Assemblies 19, 20 and 21 6062.3 orf19.6062.3 ORF Predicted by Annotation Working Group 6064 orf19.6064 Predicted ORF in Assemblies 19, 20 and 21 6065 orf19.6065 Gene transcription regulated by Mig1p and Tup1p; amphotericin B, caspofungin repressed; protein detected by mass spec in exponential and stationary phase cultures 6066 orf19.6066 Predicted ORF in Assemblies 19, 20 and 21 607 orf19.607 Predicted ORF in Assemblies 19, 20 and 21 6071 orf19.6071 Predicted ORF in Assemblies 19, 20 and 21 6072 orf19.6072 Predicted ORF in Assemblies 19, 20 and 21 6075 orf19.6075 Predicted ORF in Assemblies 19, 20 and 21 6076 orf19.6076 Predicted ORF in Assemblies 19, 20 and 21 6077 orf19.6077 Predicted ORF in Assemblies 19, 20 and 21; shows colony morphology-related gene regulation by Ssn6p 6079 orf19.6079 Predicted ORF in retrotransposon Tca8 with similarity to the Gag region encoding nucleocapsid-like protein; transcription is downregulated in response to treatment with ciclopirox olamine; filament induced; regulated by Rfg1p, Tup1p 6080 orf19.6080 Predicted ORF in Assemblies 19, 20 and 21 6082 orf19.6082 Predicted ORF in Assemblies 19, 20 and 21 6083 orf19.6083 Predicted ORF in Assemblies 19, 20 and 21 6084 orf19.6084 Predicted ORF in Assemblies 19, 20 and 21 609 orf19.609 Predicted ORF in Assemblies 19, 20 and 21; transcription is specific to white cell type 6090 orf19.6090 Predicted ORF in Assemblies 19, 20 and 21; repressed by nitric oxide 6094 orf19.6094 Predicted ORF in Assemblies 19, 20 and 21 6097 orf19.6097 Predicted ORF from Assembly 19; removed from Assembly 20 61 orf19.61 Predicted ORF from Assembly 19; removed from Assembly 20 6100 orf19.6100 Protein not essential for viability; similar to S. cerevisiae Crd1p, which is cardiolipin synthase; transcription is upregulated in clinical isolates from HIV+ patients with oral candidiasis 6101 orf19.6101 Predicted ORF from Assembly 19; removed from Assembly 20 6102 orf19.6102 Predicted ORF in Assemblies 19, 20 and 21 6103 orf19.6103 Predicted ORF in Assemblies 19, 20 and 21 6110 orf19.6110 Predicted ORF in Assemblies 19, 20 and 21 6113 orf19.6113 Predicted ORF in Assemblies 19, 20 and 21 6114 orf19.6114 Predicted ORF in Assemblies 19, 20 and 21 6115 orf19.6115 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 6117 orf19.6117 Predicted ORF in Assemblies 19, 20 and 21 6118 orf19.6118 Putative protein of unknown function, transcription is positively regulated by Tbf1p; predicted ORF in Assemblies 19, 20 and 21 6119 orf19.6119 Predicted ORF in Assemblies 19, 20 and 21 612 orf19.612 Predicted ORF in Assemblies 19, 20 and 21 613 orf19.613 Predicted ORF from Assembly 19; removed from Assembly 20 6132 orf19.6132 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 6134 orf19.6134 Predicted ORF in Assemblies 19, 20 and 21 6135 orf19.6135 Predicted ORF in Assemblies 19, 20 and 21 6136 orf19.6136 Predicted ORF in Assemblies 19, 20 and 21; repressed by nitric oxide 6137 orf19.6137 Predicted ORF in Assemblies 19, 20 and 21 6138 orf19.6138 Predicted ORF in Assemblies 19, 20 and 21; similar to ferric reductase Fre10p 614 orf19.614 Predicted ORF from Assembly 19; removed from Assembly 20 6142 orf19.6142 Predicted ORF in Assemblies 19, 20 and 21 6143 orf19.6143 Predicted ORF in Assemblies 19, 20 and 21 6147 orf19.6147 Predicted ORF in Assemblies 19, 20 and 21 6148 orf19.6148 Predicted ORF in Assemblies 19, 20 and 21 615 orf19.615 ORF Predicted by Annotation Working Group; possibly spurious ORF (Annotation Working Group prediction); removed from Assembly 20 6152 orf19.6152 Predicted ORF in Assemblies 19, 20 and 21 6153 orf19.6153 Predicted ORF from Assembly 19; removed from Assembly 20 6154 orf19.6154 Predicted ORF from Assembly 19; merged with orf19.1289 in Assembly 20 6155 orf19.6155 Predicted ORF in Assemblies 19, 20 and 21 6156 orf19.6156 Predicted ORF in Assemblies 19, 20 and 21 616 orf19.616 Predicted ORF from Assembly 19; possibly spurious ORF (Annotation Working Group prediction); removed from Assembly 20 6160 orf19.6160 Predicted ORF in Assemblies 19, 20 and 21 6162 orf19.6162 Predicted ORF from Assembly 19; removed from Assembly 20 6164 orf19.6164 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 6166 orf19.6166 Predicted ORF in Assemblies 19, 20 and 21 6168 orf19.6168 Predicted ORF in Assemblies 19, 20 and 21 6169 orf19.6169 Predicted ORF in Assemblies 19, 20 and 21; induced by Rgt1p 6169.2 orf19.6169.2 ORF Predicted by Annotation Working Group; fluconazole-downregulated; merged with orf19.2496 in Assembly 20 617 orf19.617 Predicted ORF from Assembly 19; removed from Assembly 20 6170 orf19.6170 Predicted ORF in Assemblies 19, 20 and 21 6171 orf19.6171 Predicted ORF in Assemblies 19, 20 and 21 6175 orf19.6175 Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins 6177 orf19.6177 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 6179 orf19.6179 ORF Predicted by Annotation Working Group 618 orf19.618 Predicted ORF from Assembly 19; removed from Assembly 20 6180 orf19.6180 Protein similar to Pichia anomala YDL054c and S. cerevisiae Ydl054cp; transmembrane regions predicted 6181 orf19.6181 ORF Predicted by Annotation Working Group 6182 orf19.6182 Putative transcription factor with zinc cluster DNA-binding motif 6183 orf19.6183 Predicted ORF in Assemblies 19, 20 and 21 6184 orf19.6184 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 6185 orf19.6185 Protein not essential for viability 6186 orf19.6186 Predicted ORF in Assemblies 19, 20 and 21 6187 orf19.6187 Predicted ORF in Assemblies 19, 20 and 21 6188 orf19.6188 ORF Predicted by Annotation Working Group 6189 orf19.6189 Predicted ORF in Assemblies 19, 20 and 21 619 orf19.619 Predicted ORF from Assembly 19; removed from Assembly 20 6192 orf19.6192 Predicted ORF in Assemblies 19, 20 and 21; Plc1p-regulated; possibly spurious ORF (Annotation Working Group prediction) 6194 orf19.6194 Protein not essential for viability; possibly spurious ORF (Annotation Working Group prediction) 6195 orf19.6195 Predicted ORF in Assemblies 19, 20 and 21 6196 orf19.6196 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 6197 orf19.6197 Predicted ORF in Assemblies 19, 20 and 21 6198.1 orf19.6198.1 Predicted ORF in Assemblies 19, 20 and 21; gene has intron; gene was predicted by Annotation Working Group (AWG), subsequently removed from Assembly 20 by the AWG, and later reinstated (see Locus History) 6199 orf19.6199 Predicted ORF in Assemblies 19, 20 and 21; intron in 5'-UTR 62 orf19.62 Predicted ORF from Assembly 19; merged with orf19.73 in Assembly 20 620 orf19.620 Predicted ORF from Assembly 19; removed from Assembly 20 6200 orf19.6200 Predicted ORF in Assemblies 19, 20 and 21 6203 orf19.6203 Predicted zinc-finger protein of unknown function; has similarity to S. cerevisiae Put3p, which is a transcription factor involved in the regulation of proline utilization genes 6205 orf19.6205 Predicted ORF in Assemblies 19, 20 and 21 6209 orf19.6209 Predicted membrane transporter, member of the monocarboxylate porter (MCP) family, major facilitator superfamily (MFS) 621 orf19.621 Predicted ORF from Assembly 19; possibly spurious ORF (Annotation Working Group prediction); removed from Assembly 20 6211 orf19.6211 Predicted ORF in Assemblies 19, 20 and 21 6216 orf19.6216 Putative GPI-anchored protein of unknown function; merged with orf19.6217 in Assembly 20 6219 orf19.6219 Predicted ORF in Assemblies 19, 20 and 21 6220 orf19.6220 Predicted ORF in Assemblies 19, 20 and 21 6220.4 orf19.6220.4 ORF Predicted by Annotation Working Group 6222.1 orf19.6222.1 ORF added to Assembly 21 based on comparative genome analysis 6222.2 orf19.6222.2 Region annotated in Assembly 21 as a blocked reading frame, based on comparative genome analysis; removed upon correction of a misassembled region of A21, which restores the ORF encompassing full-length SPO22/orf19.6222 (see Locus History) 6223 orf19.6223 Predicted ORF from Assembly 19; merged with orf19.6222 in Assembly 20 6224 orf19.6224 Predicted ORF in Assemblies 19, 20 and 21 6225.1 orf19.6225.1 ORF Predicted by Annotation Working Group 6227 orf19.6227 Predicted ORF in Assemblies 19, 20 and 21 6230 orf19.6230 Predicted ORF in Assemblies 19, 20 and 21 6233 orf19.6233 Predicted ORF in Assemblies 19, 20 and 21 6234 orf19.6234 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine) 6235 orf19.6235 Predicted ORF in Assemblies 19, 20 and 21 6236 orf19.6236 Predicted ORF in Assemblies 19, 20 and 21 6238 orf19.6238 Predicted ORF in Assemblies 19, 20 and 21 6239 orf19.6239 Predicted ORF in Assemblies 19, 20 and 21 624 orf19.624 Predicted ORF from Assembly 19; removed from Assembly 20 6240 orf19.6240 Predicted ORF in Assemblies 19, 20 and 21 6241 orf19.6241 Predicted ORF from Assembly 19; merged with orf19.6240 in Assembly 20 6242 orf19.6242 Predicted ORF in Assemblies 19, 20 and 21 6244 orf19.6244 Predicted ORF in Assemblies 19, 20 and 21 6245 orf19.6245 Predicted ORF in Assemblies 19, 20 and 21; regulated by osmotic stress (via Hog1p) and oxidative stress (Hog1p- and Cap1p-independent); transcription is induced in response to alpha pheromone in SpiderM medium 6246 orf19.6246 Predicted ORF in Assemblies 19, 20 and 21 6247 orf19.6247 Predicted ORF in Assemblies 19, 20 and 21 6248 orf19.6248 Predicted ORF in Assemblies 19, 20 and 21 625 orf19.625 Predicted ORF from Assembly 19; removed from Assembly 20 6250 orf19.6250 Predicted ORF in Assemblies 19, 20 and 21 6252 orf19.6252 Predicted ORF in Assemblies 19, 20 and 21 6255 orf19.6255 Predicted ORF in Assemblies 19, 20 and 21 6259 orf19.6259 Predicted ORF in Assemblies 19, 20 and 21 6260 orf19.6260 Predicted ORF in Assemblies 19, 20 and 21 6263 orf19.6263 Predicted membrane transporter, member of the monocarboxylate porter (MCP) family, major facilitator superfamily (MFS) 6264 orf19.6264 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 6264.3 orf19.6264.3 ORF Predicted by Annotation Working Group 6264.4 orf19.6264.4 ORF Predicted by Annotation Working Group 6266 orf19.6266 Predicted ORF in Assemblies 19, 20 and 21 6267 orf19.6267 Protein not essential for viability 6268 orf19.6268 Predicted ORF in Assemblies 19, 20 and 21; decreased expression observed in an ssr1 homozygous null mutant 6269 orf19.6269 Predicted ORF in Assemblies 19, 20 and 21 627 orf19.627 Predicted ORF from Assembly 19; removed from Assembly 20 6270 orf19.6270 Predicted ORF from Assembly 19; merged with orf19.6269 in Assembly 20 6271 orf19.6271 Predicted ORF in Assemblies 19, 20 and 21 6272 orf19.6272 Predicted ORF in Assemblies 19, 20 and 21; regulated by Gcn2p and Gcn4p 6273 orf19.6273 Predicted ORF in Assemblies 19, 20 and 21 6274 orf19.6274 Protein required for cohesion, adhesion, and biofilm formation; predicted ORF in Assemblies 19, 20 and 21 6275 orf19.6275 Predicted ORF in Assemblies 19, 20 and 21 6276 orf19.6276 Predicted ORF in Assemblies 19, 20 and 21 6277 orf19.6277 Predicted ORF in Assemblies 19, 20 and 21 6279 orf19.6279 Predicted ORF from Assembly 19; merged with orf19.6277 in Assembly 20 6280 orf19.6280 Predicted ORF in Assemblies 19, 20 and 21 6281 orf19.6281 Predicted ORF from Assembly 19; merged with orf19.177 in Assembly 20 6282 orf19.6282 Predicted ORF in Assemblies 19, 20 and 21 6283 orf19.6283 Predicted ORF in Assemblies 19, 20 and 21 6284 orf19.6284 Predicted ORF in Assemblies 19, 20 and 21 6286 orf19.6286 Predicted ORF in Assemblies 19, 20 and 21 6288 orf19.6288 Predicted ORF in Assemblies 19, 20 and 21 6291 orf19.6291 Predicted ORF in Assemblies 19, 20 and 21 6292 orf19.6292 Predicted ORF from Assembly 19; merged with orf19.6291 in Assembly 20 6293 orf19.6293 Predicted ORF in Assemblies 19, 20 and 21 6296 orf19.6296 Predicted ORF in Assemblies 19, 20 and 21 6297 orf19.6297 Predicted ORF in Assemblies 19, 20 and 21 6299 orf19.6299 Predicted ORF from Assembly 19; merged with orf19.4153 in Assembly 20 6301 orf19.6301 Predicted ORF from Assembly 19; clade-associated gene expression; removed from Assembly 20 6305 orf19.6305 Hydroxytrimethyllysine aldolase, the second enzyme in the carnitine biosynthesis pathway 6306 orf19.6306 Trimethylaminobutyraldehyde dehydrogenase, the third enzyme of the carnitine biosynthesis pathway 6307 orf19.6307 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 6308 orf19.6308 Predicted ORF in Assemblies 19, 20 and 21 631 orf19.631 Predicted ORF from Assembly 19; merged with orf19.2661 in Assembly 20 6310 orf19.6310 Predicted ORF in Assemblies 19, 20 and 21 6311 orf19.6311 Predicted ORF in Assemblies 19, 20 and 21 6313.2 orf19.6313.2 ORF Predicted by Annotation Working Group 6315 orf19.6315 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 6316 orf19.6316 Predicted membrane transporter, member of the L-amino acid transporter-3 (LAT3) family, major facilitator superfamily (MFS) 6316.4 orf19.6316.4 ORF Predicted by Annotation Working Group 6318 orf19.6318 Predicted ORF in Assemblies 19, 20 and 21 6319 orf19.6319 Predicted ORF in Assemblies 19, 20 and 21 632 orf19.632 Predicted ORF from Assembly 19; possibly spurious ORF (Annotation Working Group prediction); merged with orf19.1808 in Assembly 20 6323 orf19.6323 Predicted ORF in Assemblies 19, 20 and 21 6325.1 orf19.6325.1 ORF Predicted by Annotation Working Group 6326 orf19.6326 Predicted ORF in Assemblies 19, 20 and 21 6328 orf19.6328 Predicted ORF in Assemblies 19, 20 and 21 6329 orf19.6329 Predicted ORF in Assemblies 19, 20 and 21; opaque-specific transcription; fluconazole-downregulated; greater mRNA abundance in a cyr1 homozygous null mutant than in wild type; possibly spurious ORF (Annotation Working Group prediction) 633 orf19.633 Protein described as a putative methyltransferase; decreased expression in hyphae compared to yeast-form cells; expression regulated during planktonic growth 6337.1 orf19.6337.1 Region annotated in Assembly 21 as a blocked reading frame, based on comparative genome analysis; overlaps orf19.6337, which is an open reading frame 6338 orf19.6338 Predicted ORF in Assemblies 19, 20 and 21 634 orf19.634 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 6340 orf19.6340 Predicted ORF in Assemblies 19, 20 and 21 6341 orf19.6341 Predicted ORF in Assemblies 19, 20 and 21 6342 orf19.6342 Predicted ORF in Assemblies 19, 20 and 21 6343 orf19.6343 Predicted ORF in Assemblies 19, 20 and 21 6346 orf19.6346 Predicted ORF in Assemblies 19, 20 and 21; decreased transcription is observed in an azole-resistant strain that overexpresses MDR1 6347 orf19.6347 Predicted ORF in Assemblies 19, 20 and 21 6348 orf19.6348 Protein not essential for viability 635 orf19.635 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction); transcription is induced in response to alpha pheromone in SpiderM medium 635.1 orf19.635.1 ORF Predicted by Annotation Working Group; merged with orf19.555 in Assembly 20 6350 orf19.6350 Predicted ORF in Assemblies 19, 20 and 21 6351 orf19.6351 Predicted ORF in Assemblies 19, 20 and 21 6353 orf19.6353 Predicted ORF in Assemblies 19, 20 and 21 6354 orf19.6354 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 6355 orf19.6355 Predicted ORF in Assemblies 19, 20 and 21 6356 orf19.6356 Predicted ORF in Assemblies 19, 20 and 21 6357 orf19.6357 Predicted ORF in Assemblies 19, 20 and 21 6358 orf19.6358 Predicted ORF in Assemblies 19, 20 and 21 6359 orf19.6359 Predicted ORF in Assemblies 19, 20 and 21 636 orf19.636 Predicted ORF from Assembly 19; possibly spurious ORF (Annotation Working Group prediction); merged with orf19.555 in Assembly 20 6360 orf19.6360 Predicted ORF in Assemblies 19, 20 and 21 6363 orf19.6363 Predicted ORF from Assembly 19; merged with orf19.3755 in Assembly 20 6364 orf19.6364 Predicted ORF from Assembly 19; merged with orf19.589 in Assembly 20 6366 orf19.6366 Predicted ORF in Assemblies 19, 20 and 21 6369 orf19.6369 Predicted ORF in Assemblies 19, 20 and 21 6371 orf19.6371 Predicted ORF in Assemblies 19, 20 and 21 6373 orf19.6373 Predicted ORF in Assemblies 19, 20 and 21 6374 orf19.6374 Predicted ORF in Assemblies 19, 20 and 21 6377 orf19.6377 Predicted ORF in Assemblies 19, 20 and 21 6379 orf19.6379 Predicted ORF in Assemblies 19, 20 and 21 6382 orf19.6382 Putative MRP/CFTR-subfamily ABC transporter; member of multidrug resistance-associated protein (MRP) subfamily of ABC family; similar to S. cerevisiae Bpt1p 6383 orf19.6383 Predicted ORF from Assembly 19; putative MRP/CFTR-subfamily ABC transporter; merged with orf19.6382 in Assembly 20 6389 orf19.6389 Predicted ORF from Assembly 19; merged with orf19.6387 in Assembly 20 639 orf19.639 Predicted ORF in Assemblies 19, 20 and 21; decreased transcription is observed upon fluphenazine treatment or in an azole-resistant strain that overexpresses CDR1 and CDR2 639.1 orf19.639.1 ORF Predicted by Annotation Working Group 6390 orf19.6390 Predicted ORF in Assemblies 19, 20 and 21 6391 orf19.6391 Increased transcription is observed in an azole-resistant strain that overexpresses MDR1 6392 orf19.6392 Predicted ORF in Assemblies 19, 20 and 21 6393 orf19.6393 Predicted ORF in Assemblies 19, 20 and 21 6396 orf19.6396 Putative patatin-like phospholipase; similar to S. cerevisiae Yml059p, which is predicted to be a membrane protein: antigenic during human oral infection 6398 orf19.6398 Predicted ORF in Assemblies 19, 20 and 21; induced by nitric oxide 64 orf19.64 Predicted ORF from Assembly 19; removed from Assembly 20 640 orf19.640 Predicted ORF in Assemblies 19, 20 and 21 6400 orf19.6400 Predicted ORF in Assemblies 19, 20 and 21 6403 orf19.6403 Predicted ORF in Assemblies 19, 20 and 21 6405 orf19.6405 Predicted ORF in Assemblies 19, 20 and 21; decreased transcription is observed in an azole-resistant strain that overexpresses MDR1 6406 orf19.6406 Predicted ORF in Assemblies 19, 20 and 21 6407 orf19.6407 Predicted ORF in Assemblies 19, 20 and 21 6408 orf19.6408 Predicted ORF in Assemblies 19, 20 and 21; induced during planktonic growth 641 orf19.641 Predicted ORF in Assemblies 19, 20 and 21 6411 orf19.6411 Predicted ORF in Assemblies 19, 20 and 21; similar to S. cerevisiae Ylr386wp; transposon mutation affects filamentous growth 6413 orf19.6413 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 6414 orf19.6414 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 6415.1 orf19.6415.1 ORF Predicted by Annotation Working Group; intron in 5'-UTR 6416 orf19.6416 Predicted ORF in Assemblies 19, 20 and 21 6418 orf19.6418 Predicted ORF in Assemblies 19, 20 and 21 6419.1 orf19.6419.1 Predicted ORF in Assembly 20 and 21; gene has intron 642 orf19.642 Predicted ORF in Assemblies 19, 20 and 21 6423 orf19.6423 Predicted ORF in Assemblies 19, 20 and 21 6424 orf19.6424 Predicted ORF in Assemblies 19, 20 and 21 6425 orf19.6425 Predicted ORF in Assemblies 19, 20 and 21 643 orf19.643 Predicted ORF in Assemblies 19, 20 and 21 6431 orf19.6431 Predicted ORF in Assemblies 19, 20 and 21 6432 orf19.6432 Predicted ORF in Assemblies 19, 20 and 21 6434 orf19.6434 Predicted ORF in Assemblies 19, 20 and 21 6435 orf19.6435 Predicted ORF in Assemblies 19, 20 and 21 6436 orf19.6436 Predicted ORF in Assemblies 19, 20 and 21 6438 orf19.6438 Predicted ORF in Assemblies 19, 20 and 21 6440 orf19.6440 Predicted ORF in Assemblies 19, 20 and 21 6443 orf19.6443 Predicted ORF in Assemblies 19, 20 and 21 6444 orf19.6444 Predicted ORF in Assemblies 19, 20 and 21 6448 orf19.6448 Predicted ORF in Assemblies 19, 20 and 21 6449 orf19.6449 Predicted ORF in Assemblies 19, 20 and 21 645 orf19.645 Predicted ORF from Assembly 19; merged with orf19.644 in Assembly 20 645.1 orf19.645.1 ORF Predicted by Annotation Working Group 6450 orf19.6450 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 6451 orf19.6451 Predicted ORF from Assembly 19; similar to a region of the Tca2 (pCal) retrotransposon, which is present in strain hOG1042 as 50 to 100 copies of a linear dsDNA; removed from Assembly 20 6453 orf19.6453 Predicted ORF in Assemblies 19, 20 and 21 6454 orf19.6454 Predicted ORF from Assembly 19; merged with orf19.6453 in Assembly 20 6455 orf19.6455 Putative protein of unknown function, transcription is upregulated in clinical isolates from HIV+ patients with oral candidiasis; predicted ORF in Assemblies 19, 20 and 21 6456 orf19.6456 Predicted ORF in Assemblies 19, 20 and 21 6457 orf19.6457 Predicted ORF in Assemblies 19, 20 and 21 6458 orf19.6458 Predicted ORF in Assemblies 19, 20 and 21 6458.1 orf19.6458.1 ORF Predicted by Annotation Working Group 6460 orf19.6460 Predicted ORF in Assemblies 19, 20 and 21 6461 orf19.6461 Predicted ORF in Assemblies 19, 20 and 21 6462 orf19.6462 Predicted ORF in Assemblies 19, 20 and 21 6463 orf19.6463 Predicted ORF in Assemblies 19, 20 and 21; putative ortholog of S. cerevisiae Yjr072cp; possibly essential for growth (however, depletion mutant is viable) 6464 orf19.6464 Predicted ORF in Assemblies 19, 20 and 21; induced upon adherence to polystyrene; oxidative stress-induced via Cap1p 6465 orf19.6465 Predicted ORF in Assemblies 19, 20 and 21 6467 orf19.6467 Predicted ORF from Assembly 19; merged with orf19.6469 in Assembly 20 6468 orf19.6468 Predicted ORF from Assembly 19; merged with orf19.6469 in Assembly 20 6469 orf19.6469 Predicted ORF in retrotransposon Tca11 with similarity to the Gag-Pol region of retrotransposons, which encodes nucleocapsid-like protein, reverse transcriptase, protease, and integrase 647.3 orf19.647.3 ORF Predicted by Annotation Working Group 6474 orf19.6474 Predicted ORF in Assemblies 19, 20 and 21 6475 orf19.6475 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 6476 orf19.6476 Predicted ORF in Assemblies 19, 20 and 21; filament induced 6477 orf19.6477 Predicted ORF in Assemblies 19, 20 and 21 6479 orf19.6479 Predicted ORF in Assemblies 19, 20 and 21 6480 orf19.6480 Predicted ORF in Assemblies 19, 20 and 21 6482 orf19.6482 Predicted ORF in Assemblies 19, 20 and 21; induced by nitric oxide in yhb1 mutant; possibly spurious ORF (Annotation Working Group prediction) 6484 orf19.6484 Predicted ORF in Assemblies 19, 20 and 21 6487 orf19.6487 Predicted ORF in Assemblies 19, 20 and 21 6488 orf19.6488 Predicted ORF in Assemblies 19, 20 and 21 649 orf19.649 Predicted ORF in Assemblies 19, 20 and 21 6491 orf19.6491 Predicted ORF in Assemblies 19, 20 and 21 6492 orf19.6492 Predicted ORF in Assemblies 19, 20 and 21 6493 orf19.6493 Predicted ORF in Assemblies 19, 20 and 21 6498 orf19.6498 Predicted ORF in Assemblies 19, 20 and 21 6499 orf19.6499 Predicted ORF in Assemblies 19, 20 and 21 6501 orf19.6501 Predicted ORF in Assemblies 19, 20 and 21 6502 orf19.6502 Predicted ORF in Assemblies 19, 20 and 21; upregulation correlates with clinical development of fluconazole resistance 6503 orf19.6503 Predicted ORF in Assemblies 19, 20 and 21 6506 orf19.6506 Predicted ORF in Assemblies 19, 20 and 21 6507 orf19.6507 Predicted ORF in Assemblies 19, 20 and 21; protein detected by mass spec in stationary phase cultures 6508 orf19.6508 Predicted ORF in Assemblies 19, 20 and 21 6509 orf19.6509 Predicted ORF in Assemblies 19, 20 and 21 6513 orf19.6513 Predicted ORF from Assembly 19; removed from Assembly 20 6518 orf19.6518 Predicted ORF in Assemblies 19, 20 and 21 652 orf19.652 Predicted ORF in Assemblies 19, 20 and 21 6520 orf19.6520 Putative allantoate permease; fungal-specific (no human or murine homolog) 6521 orf19.6521 Predicted ORF from Assembly 19; removed from Assembly 20 6522 orf19.6522 Putative allantoate permease; fungal-specific (no human or murine homolog); Gcn4p-regulated 6524 orf19.6524 Predicted ORF in Assemblies 19, 20 and 21 6525 orf19.6525 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction); transcriptionally activated by Mnl1p under weak acid stress 6526 orf19.6526 Predicted ORF in Assemblies 19, 20 and 21 6527 orf19.6527 Predicted ORF in Assemblies 19, 20 and 21; shows colony morphology-related gene regulation by Ssn6p; transcriptionally activated by Mnl1p under weak acid stress 6528 orf19.6528 Predicted ORF in Assemblies 19, 20 and 21 653 orf19.653 Predicted ORF in Assemblies 19, 20 and 21 6530 orf19.6530 Similar to bacterial DnaJ; transcriptionally regulated by iron; expression greater in low iron 6532 orf19.6532 Predicted ORF in Assemblies 19, 20 and 21 6534 orf19.6534 Predicted ORF in Assemblies 19, 20 and 21 6534.2 orf19.6534.2 Predicted ORF in Assemblies 19, 20 and 21 6535 orf19.6535 Predicted ORF from Assembly 19; merged with orf19.6534.2 in Assembly 20 6537 orf19.6537 Predicted ORF in Assemblies 19, 20 and 21 6539 orf19.6539 Predicted ORF in Assemblies 19, 20 and 21; heterozygous null mutant displays sensitivity to virgineone 654 orf19.654 Predicted ORF in Assemblies 19, 20 and 21 6547 orf19.6547 Predicted ORF in Assemblies 19, 20 and 21 6549 orf19.6549 Predicted ORF from Assembly 19; transcription is negatively regulated by Sfu1p; removed from Assembly 20 6550 orf19.6550 Predicted ORF in Assemblies 19, 20 and 21 6551 orf19.6551 Predicted ORF in Assemblies 19, 20 and 21 6552 orf19.6552 Predicted ORF in Assemblies 19, 20 and 21 6553 orf19.6553 Predicted ORF in Assemblies 19, 20 and 21 6554 orf19.6554 Predicted ORF in Assemblies 19, 20 and 21 6555 orf19.6555 Predicted ORF in Assemblies 19, 20 and 21 6556 orf19.6556 Predicted ORF in Assemblies 19, 20 and 21 6557 orf19.6557 Predicted ORF in Assemblies 19, 20 and 21; transcriptionally activated by Mnl1p under weak acid stress 6558 orf19.6558 Predicted ORF in Assemblies 19, 20 and 21 6559 orf19.6559 Predicted ORF in Assemblies 19, 20 and 21; protein level decreased in stationary phase cultures 6563 orf19.6563 Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium 6563.1 orf19.6563.1 ORF Predicted by Annotation Working Group 6565 orf19.6565 Predicted ORF in Assemblies 19, 20 and 21 6566 orf19.6566 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 6569 orf19.6569 Predicted ORF in Assemblies 19, 20 and 21 6575 orf19.6575 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 6578 orf19.6578 Predicted membrane transporter, member of the vesicular neurotransmitter (VNT) family, major facilitator superfamily (MFS); downregulated in core caspofungin response 6579 orf19.6579 Predicted ORF in Assemblies 19, 20 and 21 6580 orf19.6580 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 6581 orf19.6581 Predicted ORF in Assemblies 19, 20 and 21 6583 orf19.6583 Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium 6585 orf19.6585 Predicted ORF in Assemblies 19, 20 and 21 6586 orf19.6586 ############################################################################################################################################################################################################################################################### 6587 orf19.6587 Protein similar to S. cerevisiae Ydr152wp; transposon mutation affects filamentous growth 6588 orf19.6588 Predicted ORF in Assemblies 19, 20 and 21 6589 orf19.6589 Predicted ORF in Assemblies 19, 20 and 21 6590 orf19.6590 Predicted ORF in Assemblies 19, 20 and 21 6591 orf19.6591 Predicted ORF in Assemblies 19, 20 and 21 6592 orf19.6592 Predicted membrane transporter, member of the aromatic acid:proton symporter (AAHS) family, major facilitator superfamily (MFS) 6596 orf19.6596 Protein of unknown function; possibly transcriptionally regulated by Tac1p; transcriptionally activated by Mnl1p under weak acid stress; protein detected by mass spec in exponential and stationary phase cultures 6597 orf19.6597 Predicted ORF in Assemblies 19, 20 and 21 6599.1 orf19.6599.1 ORF Predicted by Annotation Working Group 66 orf19.66 Predicted ORF from Assembly 19; removed from Assembly 20 660 orf19.660 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 6600 orf19.6600 Predicted ORF in Assemblies 19, 20 and 21 6601 orf19.6601 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 6602 orf19.6602 Predicted ORF in Assemblies 19, 20 and 21 6603 orf19.6603 Predicted ORF from Assembly 19; removed from Assembly 20 6604 orf19.6604 Predicted ORF in Assemblies 19, 20 and 21; greater mRNA abundance observed in a cyr1 homozygous null mutant than in wild type 6605 orf19.6605 Predicted ORF in Assemblies 19, 20 and 21 6606 orf19.6606 Predicted ORF in Assemblies 19, 20 and 21 6607 orf19.6607 Predicted ORF in Assemblies 19, 20 and 21 6608 orf19.6608 Predicted ORF in Assemblies 19, 20 and 21; downregulation correlates with clinical development of fluconazole resistance 6610 orf19.6610 Predicted ORF in Assemblies 19, 20 and 21 6612 orf19.6612 Predicted ORF in Assemblies 19, 20 and 21 6623 orf19.6623 Predicted ORF in Assemblies 19, 20 and 21 6624 orf19.6624 Predicted ORF in Assemblies 19, 20 and 21 6625 orf19.6625 Predicted ORF in Assemblies 19, 20 and 21 6626 orf19.6626 Predicted ORF in Assemblies 19, 20 and 21; possibly transcriptionally regulated upon hyphal formation 6627 orf19.6627 Predicted ORF in Assemblies 19, 20 and 21; possibly transcriptionally regulated upon hyphal formation 6628 orf19.6628 Predicted ORF in Assemblies 19, 20 and 21 6630 orf19.6630 ORF Predicted by Annotation Working Group 6631 orf19.6631 Predicted ORF from Assembly 19; removed from Assembly 20 6635 orf19.6635 Predicted ORF in Assemblies 19, 20 and 21 6636 orf19.6636 Predicted ORF in Assemblies 19, 20 and 21 6637 orf19.6637 Predicted ORF in Assemblies 19, 20 and 21 6639 orf19.6639 Predicted ORF in Assemblies 19, 20 and 21 664 orf19.664 Predicted ORF in Assemblies 19, 20 and 21 6641 orf19.6641 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 6642 orf19.6642 Predicted ORF in Assemblies 19, 20 and 21 6644 orf19.6644 Predicted ORF in Assemblies 19, 20 and 21 6650 orf19.6650 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 6653 orf19.6653 Predicted ORF in Assemblies 19, 20 and 21 6654 orf19.6654 Predicted membrane transporter, member of the L-amino acid transporter-3 (LAT3) family, major facilitator superfamily (MFS) 6658 orf19.6658 Predicted ORF from Assembly 19; removed from Assembly 20; subsequently reinstated in Assembly 21 based on comparative genome analysis; protein detected by mass spec in stationary phase cultures 666 orf19.666 Predicted ORF in Assemblies 19, 20 and 21 6660 orf19.6660 Predicted ORF in Assemblies 19, 20 and 21 6661 orf19.6661 Predicted ORF from Assembly 19; removed from Assembly 20; subsequently reinstated in Assembly 21 based on comparative genome analysis 6662 orf19.6662 Putative protein of unknown function, transcription is upregulated in clinical isolates from HIV+ patients with oral candidiasis; predicted ORF in Assemblies 19, 20 and 21 6665 orf19.6665 Predicted ORF in Assemblies 19, 20 and 21 6667 orf19.6667 Predicted ORF in Assemblies 19, 20 and 21 6668 orf19.6668 Predicted ORF in Assemblies 19, 20 and 21 667 orf19.667 Predicted ORF from Assembly 19; merged with orf19.666 in Assembly 20 6672 orf19.6672 Predicted ORF in Assemblies 19, 20 and 21 6675 orf19.6675 Predicted ORF from Assembly 19; induced upon biofilm formation; removed from Assembly 20 6676 orf19.6676 Predicted ORF in Assemblies 19, 20 and 21 6678 orf19.6678 Predicted ORF in Assemblies 19, 20 and 21 6679 orf19.6679 Predicted ORF in Assemblies 19, 20 and 21 668 orf19.668 Predicted ORF in Assemblies 19, 20 and 21 6681 orf19.6681 Predicted ORF in Assemblies 19, 20 and 21 6682 orf19.6682 Predicted ORF from Assembly 19; merged with orf19.1124.2 in Assembly 20 6683 orf19.6683 Predicted ORF from Assembly 19; merged with orf19.6707 in Assembly 20 6687 orf19.6687 Predicted ORF in Assemblies 19, 20 and 21 6688 orf19.6688 Decreased transcription is observed upon benomyl treatment or in an azole-resistant strain that overexpresses MDR1 6690 orf19.6690 Predicted ORF in Assemblies 19, 20 and 21 6691 orf19.6691 Predicted ORF in Assemblies 19, 20 and 21 6693 orf19.6693 Predicted ORF in Assemblies 19, 20 and 21 6694 orf19.6694 Predicted ORF in Assemblies 19, 20 and 21 6698 orf19.6698 Predicted ORF in Assemblies 19, 20 and 21 6699 orf19.6699 Predicted ORF in Assemblies 19, 20 and 21 67 orf19.67 Predicted ORF from Assembly 19; possibly spurious ORF (Annotation Working Group prediction); merged with orf19.2664 in Assembly 20 670.2 orf19.670.2 ORF Predicted by Annotation Working Group 6701 orf19.6701 Predicted ORF in Assemblies 19, 20 and 21; protein detected by mass spec in stationary phase cultures 6703 orf19.6703 Predicted ORF in Assemblies 19, 20 and 21 6704 orf19.6704 Predicted ORF in Assemblies 19, 20 and 21 6705 orf19.6705 Putative guanyl nucleotide exchange factor with Sec7 domain; transcriptionally regulated upon yeast-hyphal switch; filament induced; regulated by Nrg1p, Tup1p; shows Mob2p-dependent hyphal regulation 6707 orf19.6707 Predicted ORF in Assemblies 19, 20 and 21; transcription is repressed in response to alpha pheromone in SpiderM medium 6708 orf19.6708 Decreased transcription is observed in an azole-resistant strain that overexpresses MDR1; merged with orf19.6684 in Assembly 20 6709 orf19.6709 Predicted ORF in Assemblies 19, 20 and 21 6712 orf19.6712 Predicted ORF in Assemblies 19, 20 and 21 6713 orf19.6713 Predicted ORF in Assemblies 19, 20 and 21 6715 orf19.6715 Predicted ORF in Assemblies 19, 20 and 21 6717 orf19.6717 Predicted ORF in Assemblies 19, 20 and 21 6718 orf19.6718 Predicted ORF in Assemblies 19, 20 and 21 6719 orf19.6719 Predicted ORF in Assemblies 19, 20 and 21; intron annotated in Assembly 21 based on comparative genome analysis 672 orf19.672 Predicted ORF in Assemblies 19, 20 and 21 6720 orf19.6720 Predicted ORF in Assemblies 19, 20 and 21; similar to S. cerevisiae Ydr090cp; transposon mutation affects filamentous growth 6722 orf19.6722 Predicted ORF in Assemblies 19, 20 and 21; similar to S. cerevisiae Rad4p; down-regulation associated with azole resistance 6723 orf19.6723 Predicted ORF in Assemblies 19, 20 and 21 6724.1 orf19.6724.1 ORF Predicted by Annotation Working Group; merged with orf19.6724 in Assembly 20 6725 orf19.6725 Protein described as similar to fumarate hydratase, enzyme of citric acid cycle; fluconazole-downregulated; downregulated by Efg1p; merged with orf19.6724 in Assembly 20 6726 orf19.6726 Predicted ORF in Assemblies 19, 20 and 21 673 orf19.673 Predicted ORF in Assemblies 19, 20 and 21 6730 orf19.6730 Predicted ORF in Assemblies 19, 20 and 21 6731 orf19.6731 Predicted ORF in Assemblies 19, 20 and 21; transcription is repressed in response to alpha pheromone in SpiderM medium 6731.1 orf19.6731.1 ORF Predicted by Annotation Working Group 6732 orf19.6732 Predicted ORF in Assemblies 19, 20 and 21 6736 orf19.6736 Predicted ORF in Assemblies 19, 20 and 21 6737 orf19.6737 Protein not essential for viability; greater mRNA abundance observed in a cyr1, ras1, or efg1 homozygous null mutant than in wild type; possibly spurious ORF (Annotation Working Group prediction) 6739 orf19.6739 Predicted ORF in Assemblies 19, 20 and 21 674 orf19.674 Predicted ORF in Assemblies 19, 20 and 21 6740 orf19.6740 Predicted ORF in Assemblies 19, 20 and 21 6741 orf19.6741 Predicted ORF in Assemblies 19, 20 and 21; regulated by Nrg1p, Tup1p 6742 orf19.6742 Predicted ORF in Assemblies 19, 20 and 21 6744 orf19.6744 Predicted ORF in Assemblies 19, 20 and 21 6747 orf19.6747 Predicted ORF in Assemblies 19, 20 and 21 6748 orf19.6748 Predicted ORF in Assemblies 19, 20 and 21 675 orf19.675 Similar to cell wall proteins; induced in core stress response, core caspofungin response; iron-regulated; amphotericin B induced; regulated by Cyr1p, Ssn6p; possibly spurious ORF (Annotation Working Group prediction) 675.1 orf19.675.1 ORF added to Assembly 21 based on comparative genome analysis 6751 orf19.6751 Predicted ORF in Assemblies 19, 20 and 21 6752 orf19.6752 Predicted ORF in Assemblies 19, 20 and 21 6753 orf19.6753 Predicted ORF in Assemblies 19, 20 and 21 6754 orf19.6754 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 6755 orf19.6755 Predicted ORF in Assemblies 19, 20 and 21 6756 orf19.6756 Predicted ORF in Assemblies 19, 20 and 21 6758 orf19.6758 Predicted ORF in Assemblies 19, 20 and 21 6759 orf19.6759 Predicted ORF in Assemblies 19, 20 and 21 676 orf19.676 Predicted ORF in Assemblies 19, 20 and 21 6766 orf19.6766 Predicted ORF in Assemblies 19, 20 and 21 6769 orf19.6769 Predicted ORF in Assemblies 19, 20 and 21 6770 orf19.6770 Predicted ORF in Assemblies 19, 20 and 21 6772 orf19.6772 Predicted ORF from Assembly 19; merged with orf19.6773 in Assembly 20 6777 orf19.6777 Predicted ORF in Assemblies 19, 20 and 21 6778 orf19.6778 Predicted ORF in Assemblies 19, 20 and 21 6781 orf19.6781 Putative transcription factor with zinc finger DNA-binding motif 6783 orf19.6783 Predicted ORF in Assemblies 19, 20 and 21 6786 orf19.6786 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 6787 orf19.6787 Predicted ORF in Assemblies 19, 20 and 21 6788 orf19.6788 Predicted ORF in Assemblies 19, 20 and 21 6789 orf19.6789 Predicted ORF in Assemblies 19, 20 and 21 6790 orf19.6790 Predicted ORF in Assemblies 19, 20 and 21 6793 orf19.6793 Predicted ORF in Assemblies 19, 20 and 21 6795 orf19.6795 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 6796 orf19.6796 Predicted ORF in Assemblies 19, 20 and 21 6797 orf19.6797 Predicted ORF in Assemblies 19, 20 and 21 68 orf19.68 Predicted ORF from Assembly 19; removed from Assembly 20 68.2 orf19.68.2 ORF Predicted by Annotation Working Group 680 orf19.680 Predicted ORF in Assemblies 19, 20 and 21 6801 orf19.6801 Putative ortholog of S. cerevisiae RPD3, which encodes a histone deacetylase; predicted ORF in Assemblies 19, 20 and 21 6802 orf19.6802 Predicted ORF in Assemblies 19, 20 and 21 6804 orf19.6804 Predicted ORF in Assemblies 19, 20 and 21 6805 orf19.6805 Predicted ORF in Assemblies 19, 20 and 21 6807 orf19.6807 Predicted ORF in retrotransposon Tca17 with similarity to parts of the Gag-Pol region of retrotransposons; clade-associated gene expression 6808 orf19.6808 Predicted ORF from Assembly 19; removed from Assembly 20 6809 orf19.6809 Predicted ORF in Assemblies 19, 20 and 21 6810 orf19.6810 Predicted ORF in Assemblies 19, 20 and 21 6811 orf19.6811 Predicted ORF in Assemblies 19, 20 and 21 6813 orf19.6813 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 6816 orf19.6816 Predicted ORF in Assemblies 19, 20 and 21 6818 orf19.6818 Predicted ORF in Assemblies 19, 20 and 21 682 orf19.682 Predicted ORF from Assembly 19; ketoconazole-induced; fluconazole-downregulated; induced in a cyr1 homozygous null mutant; shows colony morphology-related gene regulation by Ssn6p; merged with orf19.2296 in Assembly 20 6820 orf19.6820 Predicted ORF in Assemblies 19, 20 and 21 6821 orf19.6821 Predicted ORF in Assemblies 19, 20 and 21 6822 orf19.6822 Predicted ORF in Assemblies 19, 20 and 21 6824 orf19.6824 Predicted ORF in Assemblies 19, 20 and 21; appears to be C. albicans-specific; induced upon biofilm formation; transcription is repressed in response to alpha pheromone in SpiderM medium 6828 orf19.6828 Predicted ORF in Assemblies 19, 20 and 21 6828.1 orf19.6828.1 ORF Predicted by Annotation Working Group 6829 orf19.6829 Predicted ORF in Assemblies 19, 20 and 21 683 orf19.683 Predicted ORF from Assemblies 19 and 20; identical to orf19.3391; merged with orf19.3391 in Assembly 20 (see Locus History) 6830 orf19.6830 Putative enoyl-CoA hydratase 6832 orf19.6832 Predicted ORF in Assemblies 19, 20 and 21 6833 orf19.6833 Predicted ORF from Assembly 19; merged with orf19.6832 in Assembly 20 6833.2 orf19.6833.2 ORF Predicted by Annotation Working Group 6834 orf19.6834 Predicted ORF from Assembly 19; removed from Assembly 20 6835 orf19.6835 Predicted ORF from Assembly 19; transcription is negatively regulated by Sfu1p; removed from Assembly 20 6836 orf19.6836 Predicted ORF from Assembly 19; removed from Assembly 20 6837 orf19.6837 Predicted ORF in Assemblies 19, 20 and 21 6838 orf19.6838 Putative protein of unknown function, transcription is upregulated in clinical isolates from HIV+ patients with oral candidiasis; predicted ORF in Assemblies 19, 20 and 21 684 orf19.684 Putative transcription factor with zinc finger DNA-binding motif; heterozygous null mutant exhibits hypersensitivity to parnafungin and cordycepin in the C. albicans fitness test 6840 orf19.6840 Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium 6842 orf19.6842 Predicted ORF in Assemblies 19, 20 and 21; transcriptionally activated by Mnl1p under weak acid stress 6843 orf19.6843 Predicted ORF in Assemblies 19, 20 and 21 6845 orf19.6845 Putative transcription factor with bZIP DNA-binding motif 6847 orf19.6847 Predicted ORF in Assemblies 19, 20 and 21; virulence-group-correlated expression 685.1 orf19.685.1 ORF added to Assembly 21 based on comparative genome analysis 6850 orf19.6850 Putative transcription factor with C3HC4 zinc finger DNA-binding motif; not essential for viability 6852 orf19.6852 Predicted ORF in Assemblies 19, 20 and 21 6852.1 orf19.6852.1 ORF added to Assembly 21 based on comparative genome analysis 6853 orf19.6853 Predicted ORF in Assemblies 19, 20 and 21 6855 orf19.6855 Predicted ORF in Assemblies 19, 20 and 21 6856 orf19.6856 Predicted ORF from Assembly 19; merged with orf19.748 in Assembly 20 6857 orf19.6857 Predicted ORF from Assembly 19; merged with orf19.748 in Assembly 20 6858 orf19.6858 Protein not essential for viability 6859 orf19.6859 Predicted ORF in Assemblies 19, 20 and 21 686 orf19.686 Predicted ORF in Assemblies 19, 20 and 21; regulated by Nrg1p 6860 orf19.6860 Predicted ORF in Assemblies 19, 20 and 21 6861 orf19.6861 Predicted ORF in Assemblies 19, 20 and 21 6862 orf19.6862 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine) 6864 orf19.6864 Predicted ORF in Assemblies 19, 20 and 21 6865 orf19.6865 Predicted ORF from Assembly 19; merged with orf19.2631 in Assembly 20 6866 orf19.6866 Putative U1-70K component of the U1 snRNP, involved in splicing; ortholog of S. cerevisiae SNP1; downregulated upon adherence to polystyrene; predicted ORF in Assemblies 19, 20 and 21 6867 orf19.6867 Predicted ORF in Assemblies 19, 20 and 21; transcription is repressed in response to alpha pheromone in SpiderM medium 6868 orf19.6868 Predicted ORF in Assemblies 19, 20 and 21 6869 orf19.6869 Predicted ORF in Assemblies 19, 20 and 21 687 orf19.687 Predicted ORF in Assemblies 19, 20 and 21 6871 orf19.6871 Predicted ORF in Assemblies 19, 20 and 21 6872 orf19.6872 Predicted ORF in Assemblies 19, 20 and 21 6873.1 orf19.6873.1 ORF Predicted by Annotation Working Group 6874 orf19.6874 Predicted ORF in Assemblies 19, 20 and 21 6877 orf19.6877 Predicted ORF in Assemblies 19, 20 and 21; transcription is upregulated in response to treatment with caspofungin, ciclopirox olamine or ketoconazole; gene of core caspofungin response 6879 orf19.6879 Predicted ORF in Assemblies 19, 20 and 21 688 orf19.688 Predicted ORF in Assemblies 19, 20 and 21 6880 orf19.6880 Predicted ORF in Assemblies 19, 20 and 21 6882.1 orf19.6882.1 ORF Predicted by Annotation Working Group 6883 orf19.6883 Predicted ORF in Assemblies 19, 20 and 21 6884 orf19.6884 Predicted ORF in Assemblies 19, 20 and 21 6886 orf19.6886 Predicted ORF in Assemblies 19, 20 and 21 6887 orf19.6887 Predicted ORF from Assembly 19; repressed by nitric oxide; removed from Assembly 20; subsequently reinstated in Assembly 21 based on comparative genome analysis 6888 orf19.6888 Protein with Gal4p-like DNA-binding domain; gene transcription regulated by Mig1p and Tup1p 6893 orf19.6893 Predicted ORF in Assemblies 19, 20 and 21 6894 orf19.6894 Predicted ORF from Assembly 19; merged with orf19.6893 in Assembly 20 6895 orf19.6895 Predicted ORF from Assembly 19; merged with orf19.5204 in Assembly 20 6896 orf19.6896 Predicted ORF in Assemblies 19, 20 and 21; member of a family encoded by FGR6-related genes in the RB2 repeat sequence 6897 orf19.6897 Predicted ORF in Assemblies 19, 20 and 21 6898 orf19.6898 Predicted ORF in Assemblies 19, 20 and 21; increased transcription is observed upon benomyl treatment or in an azole-resistant strain that overexpresses MDR1 6898.1 orf19.6898.1 ORF Predicted by Annotation Working Group 6899 orf19.6899 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to toxic ergosterol analog 69 orf19.69 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction); transcriptionally activated by Mnl1p under weak acid stress 69.2 orf19.69.2 ORF Predicted by Annotation Working Group 6900 orf19.6900 Predicted ORF in Assemblies 19, 20 and 21 6901 orf19.6901 Predicted ORF in Assemblies 19, 20 and 21 6903 orf19.6903 Predicted ORF in Assemblies 19, 20 and 21 6905 orf19.6905 Predicted ORF in Assemblies 19, 20 and 21 6907 orf19.6907 Predicted ORF in Assemblies 19, 20 and 21 6908 orf19.6908 Predicted ORF in Assemblies 19, 20 and 21 6909 orf19.6909 Predicted ORF in Assemblies 19, 20 and 21 6911 orf19.6911 Predicted ORF in Assemblies 19, 20 and 21 6912 orf19.6912 Putative ethanolamine kinase 6916 orf19.6916 Predicted ORF in Assemblies 19, 20 and 21 6917 orf19.6917 Predicted ORF in Assemblies 19, 20 and 21 6918 orf19.6918 Predicted ORF in Assemblies 19, 20 and 21 6919 orf19.6919 Predicted ORF in Assemblies 19, 20 and 21 692 orf19.692 Predicted ORF in Assemblies 19, 20 and 21 6920 orf19.6920 Predicted ORF in Assemblies 19, 20 and 21; induced upon biofilm formation; possibly spurious ORF (Annotation Working Group prediction) 6921 orf19.6921 Predicted ORF in Assemblies 19, 20 and 21 6922 orf19.6922 Predicted ORF in Assemblies 19, 20 and 21 6923 orf19.6923 Predicted ORF in Assemblies 19, 20 and 21 6923.1 orf19.6923.1 ORF added to Assembly 21 based on comparative genome analysis 6929 orf19.6929 Predicted ORF in Assemblies 19, 20 and 21 693 orf19.693 Predicted ORF in Assemblies 19, 20 and 21 6931 orf19.6931 Putative protein of unknown function; heterozygous null mutant exhibits hypersensitivity to parnafungin and cordycepin in the C. albicans fitness test; predicted ORF in Assemblies 19, 20 and 21 6933 orf19.6933 Predicted ORF in Assemblies 19, 20 and 21 6934 orf19.6934 Predicted ORF in Assemblies 19, 20 and 21 6939 orf19.6939 Predicted ORF from Assembly 19; removed from Assembly 20 6940 orf19.6940 ORF Predicted by Annotation Working Group; possibly spurious ORF (Annotation Working Group prediction) 6941 orf19.6941 Predicted ORF in Assemblies 19, 20 and 21 6943 orf19.6943 Predicted ORF from Assembly 19; removed from Assembly 20; subsequently reinstated in Assembly 21 based on comparative genome analysis 6949 orf19.6949 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 6950 orf19.6950 Protein not essential for viability 6951 orf19.6951 Predicted ORF in Assemblies 19, 20 and 21 6952 orf19.6952 Protein not essential for viability 6957 orf19.6957 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 6957.3 orf19.6957.3 ORF Predicted by Annotation Working Group; removed from Assembly 20 6960 orf19.6960 Predicted ORF from Assembly 19; removed from Assembly 20 6961 orf19.6961 Predicted ORF from Assembly 19; removed from Assembly 20 6962 orf19.6962 Predicted ORF from Assembly 19; removed from Assembly 20 6963 orf19.6963 Predicted ORF from Assembly 19; removed from Assembly 20 6964 orf19.6964 Predicted ORF from Assembly 19; removed from Assembly 20 6966 orf19.6966 Predicted ORF in Assemblies 19, 20 and 21 6968 orf19.6968 Predicted ORF in Assemblies 19, 20 and 21; Hog1p-downregulated 697 orf19.697 Predicted ORF in Assemblies 19, 20 and 21 6970 orf19.6970 Protein not essential for viability; possibly spurious ORF (Annotation Working Group prediction) 6973 orf19.6973 Predicted ORF in Assemblies 19, 20 and 21; regulated by Gcn2p and Gcn4p 6976 orf19.6976 Predicted membrane transporter; member of the proton coupled folate transporter/heme carrier protein (PCFT/HCP) family, major facilitator superfamily (MFS); virulence-group-correlated expression 6978 orf19.6978 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 6979 orf19.6979 Predicted ORF in Assemblies 19, 20 and 21; intron in 5'-UTR 698 orf19.698 Predicted ORF in Assemblies 19, 20 and 21 6980 orf19.6980 Predicted ORF in Assemblies 19, 20 and 21 6981 orf19.6981 Predicted ORF in Assemblies 19, 20 and 21 6982 orf19.6982 Predicted ORF in Assemblies 19, 20 and 21 6983 orf19.6983 Predicted ORF in Assemblies 19, 20 and 21; repressed by nitric oxide 6984 orf19.6984 Predicted ORF in Assemblies 19, 20 and 21 6986 orf19.6986 Predicted ORF in Assemblies 19, 20 and 21 6988 orf19.6988 Predicted ORF in Assemblies 19, 20 and 21 6989 orf19.6989 Predicted ORF in Assemblies 19, 20 and 21 699 orf19.699 Predicted ORF in Assemblies 19, 20 and 21 6990 orf19.6990 Predicted ORF in Assemblies 19, 20 and 21 6992 orf19.6992 Predicted membrane transporter, member of the drug:proton antiporter (12 spanner) (DHA1) family, major facilitator superfamily (MFS) 6995 orf19.6995 Predicted ORF in Assemblies 19, 20 and 21 6996 orf19.6996 Predicted ORF in Assemblies 19, 20 and 21 6997 orf19.6997 Predicted ORF in Assemblies 19, 20 and 21 6999 orf19.6999 Predicted ORF in Assemblies 19, 20 and 21 7 orf19.7 Predicted ORF from Assembly 19; removed from Assembly 20 70 orf19.70 Predicted ORF from Assembly 19; removed from Assembly 20 7002 orf19.7002 Predicted ORF in Assemblies 19, 20 and 21 7003 orf19.7003 Predicted ORF from Assembly 19; possibly spurious ORF (Annotation Working Group prediction); removed from Assembly 20 7004 orf19.7004 Predicted ORF from Assembly 19; removed from Assembly 20 7005 orf19.7005 Predicted ORF from Assembly 19; removed from Assembly 20 7006 orf19.7006 Predicted ORF in Assemblies 19, 20 and 21 7007 orf19.7007 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 7009 orf19.7009 Predicted ORF in Assemblies 19, 20 and 21 7010 orf19.7010 Predicted ORF in Assemblies 19, 20 and 21 7011 orf19.7011 Predicted ORF in Assemblies 19, 20 and 21 7012 orf19.7012 Predicted ORF in Assemblies 19, 20 and 21 7013 orf19.7013 Predicted ORF in Assemblies 19, 20 and 21 7014 orf19.7014 Putative protein of unknown function, transcription is positively regulated by Tbf1p; ORF Predicted by Annotation Working Group 702 orf19.702 Predicted ORF in Assemblies 19, 20 and 21 7020 orf19.7020 Protein similar to S. cerevisiae Kex1p, which is a pheromone-processing peptidase; possible Kex2p substrate 7022 orf19.7022 Predicted ORF in Assemblies 19, 20 and 21 7023 orf19.7023 Predicted ORF in Assemblies 19, 20 and 21; oxidative stress-induced via Cap1p 7024 orf19.7024 Predicted ORF in Assemblies 19, 20 and 21 7027 orf19.7027 Predicted ORF in Assemblies 19, 20 and 21; merged with orf19.7028 in Assembly 21 7028 orf19.7028 Predicted ORF in Assemblies 19, 20 and 21; merged with orf19.7027 in Assembly 21 7029 orf19.7029 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to toxic ergosterol analog 703 orf19.703 Predicted ORF in Assemblies 19, 20 and 21 7032 orf19.7032 Predicted ORF in Assemblies 19, 20 and 21 7033 orf19.7033 Putative dual specificity protein phosphatase, similar to S. cerevisiae Pps1p 7034 orf19.7034 Predicted ORF in Assemblies 19, 20 and 21 7036 orf19.7036 Predicted ORF in Assemblies 19, 20 and 21 7038 orf19.7038 Predicted ORF in Assemblies 19, 20 and 21 7039 orf19.7039 Predicted ORF from Assembly 19; merged with orf19.7038 in Assembly 20 7041 orf19.7041 Putative protein of unknown function; heterozygous null mutant exhibits hypersensitivity to parnafungin and cordycepin in the C. albicans fitness test; predicted ORF in Assemblies 19, 20 and 21 7042 orf19.7042 Increased transcription is observed upon benomyl treatment or in an azole-resistant strain that overexpresses MDR1; induced by nitric oxide 7043 orf19.7043 Predicted ORF in Assemblies 19, 20 and 21 7044 orf19.7044 Predicted ORF in Assemblies 19, 20 and 21 7048 orf19.7048 Predicted ORF from Assembly 19; merged with orf19.7047 in Assembly 20 7051 orf19.7051 Predicted ORF in Assemblies 19, 20 and 21 7052 orf19.7052 Predicted ORF in Assemblies 19, 20 and 21 7054 orf19.7054 Predicted ORF in Assemblies 19, 20 and 21 7055 orf19.7055 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 7056 orf19.7056 Putative protein of unknown function, transcription is upregulated in clinical isolates from HIV+ patients with oral candidiasis; predicted ORF in Assemblies 19, 20 and 21 7057 orf19.7057 Predicted ORF in Assemblies 19, 20 and 21; protein detected by mass spec in stationary phase cultures 7058 orf19.7058 Predicted ORF in Assemblies 19, 20 and 21 7059 orf19.7059 Predicted ORF in Assemblies 19, 20 and 21 7060 orf19.7060 Predicted ORF in Assemblies 19, 20 and 21 7061 orf19.7061 Predicted ORF in Assemblies 19, 20 and 21 7063 orf19.7063 Predicted ORF in Assemblies 19, 20 and 21 7067 orf19.7067 Predicted ORF in Assemblies 19, 20 and 21 7069 orf19.7069 Predicted ORF in Assemblies 19, 20 and 21 7070 orf19.7070 ORF Predicted by Annotation Working Group 7073 orf19.7073 Predicted ORF in Assemblies 19, 20 and 21 7074 orf19.7074 Predicted ORF in Assemblies 19, 20 and 21 7076 orf19.7076 Predicted ORF in Assemblies 19, 20 and 21; protein level decreased in stationary phase cultures 7077 orf19.7077 Protein with similarity to ferric reductases; transcription is activated by Mac1p under copper starvation; Plc1p-regulated; transcription is negatively regulated by Rim101p 7078 orf19.7078 Predicted ORF in Assemblies 19, 20 and 21 7079 orf19.7079 Predicted ORF in Assemblies 19, 20 and 21 708 orf19.708 Predicted ORF in Assemblies 19, 20 and 21 7082 orf19.7082 Predicted ORF in Assemblies 19, 20 and 21 7084 orf19.7084 7085 orf19.7085 Predicted ORF in Assemblies 19, 20 and 21; induced in core stress response; induced by heavy metal (cadmium) stress via Hog1p; oxidative stress-induced via Cap1p; induced by Mnl1p under weak acid stress; macrophage-downregulated 7086 orf19.7086 Predicted ORF in Assemblies 19, 20 and 21 7088 orf19.7088 Predicted ORF in Assemblies 19, 20 and 21 7091 orf19.7091 Predicted ORF in Assemblies 19, 20 and 21; induced by nitric oxide 7092 orf19.7092 Predicted ORF in Assemblies 19, 20 and 21 7095 orf19.7095 Predicted ORF in Assemblies 19, 20 and 21 7096 orf19.7096 Predicted ORF in Assemblies 19, 20 and 21 7097 orf19.7097 Putative protein of unknown function; heterozygous null mutant exhibits hypersensitivity to parnafungin and cordycepin in the C. albicans fitness test; predicted ORF in Assemblies 19, 20 and 21 7098 orf19.7098 Predicted ORF in Assemblies 19, 20 and 21; repressed by nitric oxide 71 orf19.71 Predicted ORF in Assembly 19 and 21; deleted from/reinstated in Assembly 20 (see Locus History) 710 orf19.710 Protein described as beta subunit of succinate-CoA ligase; transcription regulated by Mig1p and Tup1p; transcriptionally regulated by iron; expression greater in high iron; merged with orf19.1860 in Assembly 20 7100 orf19.7100 Predicted ORF in Assemblies 19, 20 and 21; possibly transcriptionally regulated upon hyphal formation 7101 orf19.7101 Predicted ORF in Assemblies 19, 20 and 21 7102 orf19.7102 Predicted ORF in Assemblies 19, 20 and 21 7103 orf19.7103 Predicted ORF in Assemblies 19, 20 and 21 7104 orf19.7104 Predicted ORF in Assemblies 19, 20 and 21; similar to mucins and to a Litomosoides microfilarial sheath protein 7106 orf19.7106 Predicted ORF in Assemblies 19, 20 and 21 7107 orf19.7107 Predicted ORF in Assemblies 19, 20 and 21 7108 orf19.7108 Predicted ORF in Assemblies 19, 20 and 21; protein detected by mass spec in stationary phase cultures 7109 orf19.7109 Predicted ORF in Assemblies 19, 20 and 21 711 orf19.711 Predicted ORF from Assembly 19; induced by nitric oxide; removed from Assembly 20 7110 orf19.7110 Predicted ORF in Assemblies 19, 20 and 21 7111 orf19.7111 Predicted ORF in Assemblies 19, 20 and 21 7116 orf19.7116 Putative protein of unknown function, transcription is upregulated in an RHE model of oral candidiasis; predicted ORF in Assemblies 19, 20 and 21 7118 orf19.7118 Predicted ORF in Assemblies 19, 20 and 21 7119 orf19.7119 Predicted ORF in Assemblies 19, 20 and 21 7121 orf19.7121 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 7123 orf19.7123 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 7125 orf19.7125 Predicted ORF in Assemblies 19, 20 and 21 7127.1 orf19.7127.1 Putative protein of unknown function, transcription is upregulated in an RHE model of oral candidiasis; ORF Predicted by Annotation Working Group 713 orf19.713 Predicted ORF in Assemblies 19, 20 and 21 7130 orf19.7130 Predicted ORF in Assemblies 19, 20 and 21 7131 orf19.7131 Butyrobetaine dioxygenase, the fourth enzyme of the carnitine biosynthesis pathway 7139 orf19.7139 Predicted ORF in Assemblies 19, 20 and 21 714 orf19.714 Predicted ORF in Assemblies 19, 20 and 21 7140 orf19.7140 Putative protein of unknown function, transcription is upregulated in clinical isolates from HIV+ patients with oral candidiasis; predicted ORF in Assemblies 19, 20 and 21; protein detected by mass spec in stationary phase cultures 7144 orf19.7144 Predicted ORF in Assemblies 19, 20 and 21 7145 orf19.7145 Predicted ORF from Assembly 19; removed from Assembly 20 7147 orf19.7147 Predicted ORF from Assembly 19; removed from Assembly 20 7149 orf19.7149 Predicted ORF in Assemblies 19, 20 and 21 715 orf19.715 Predicted ORF in Assemblies 19, 20 and 21 7151 orf19.7151 Predicted ORF in Assemblies 19, 20 and 21 7152 orf19.7152 Protein similar to Aspergillus CYSK O-acetylserine sulfhydrylase, suggesting that C. albicans uses an O-acetyl-serine (OAS) pathway of sulfur assimilation; upregulated in biofilm; protein level decreased in stationary phase cultures 7153 orf19.7153 Putative exportin, member of the Exportin-T family; predicted ORF in Assemblies 19, 20 and 21 7157 orf19.7157 Predicted ORF in Assemblies 19, 20 and 21 7158 orf19.7158 Protein of allantoate permease family; fungal-specific (no human or murine homolog) 7159 orf19.7159 Predicted ORF in Assemblies 19, 20 and 21 716 orf19.716 Predicted ORF in Assemblies 19, 20 and 21; regulated by Nrg1p, Tup1p; transcription is repressed in response to alpha pheromone in SpiderM medium 7160 orf19.7160 Predicted ORF in Assemblies 19, 20 and 21 7163 orf19.7163 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 7164 orf19.7164 Predicted ORF in Assemblies 19, 20 and 21 7165 orf19.7165 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 7166 orf19.7166 Predicted ORF in Assemblies 19, 20 and 21; increased transcription is observed in an azole-resistant strain that overexpresses MDR1; transcriptionally activated by Mnl1p under weak acid stress 7167 orf19.7167 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 7170 orf19.7170 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 7173 orf19.7173 Predicted ORF in Assemblies 19, 20 and 21 7179 orf19.7179 Predicted ORF in Assemblies 19, 20 and 21 7181 orf19.7181 Predicted ORF in Assemblies 19, 20 and 21 7182 orf19.7182 Predicted ORF in Assemblies 19, 20 and 21 7183 orf19.7183 Predicted ORF in Assemblies 19, 20 and 21 7184 orf19.7184 Predicted ORF in Assemblies 19, 20 and 21 7185 orf19.7185 Predicted ORF in Assemblies 19, 20 and 21 7189 orf19.7189 Predicted ORF from Assembly 19; removed from Assembly 20 719 orf19.719 Predicted ORF in Assemblies 19, 20 and 21 7192 orf19.7192 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 7193 orf19.7193 Predicted ORF in Assemblies 19, 20 and 21 7194 orf19.7194 Protein not essential for viability; decreased transcription is observed upon fluphenazine treatment; induced upon adherence to polystyrene 7196 orf19.7196 Protein described as a vacuolar protease; upregulated in the presence of human neutrophils 7197 orf19.7197 Putative protein of unknown function; heterozygous null mutant exhibits resistance to parnafungin in the C. albicans fitness test; predicted ORF in Assemblies 19, 20 and 21 7198 orf19.7198 Predicted ORF in Assemblies 19, 20 and 21 7199 orf19.7199 Predicted ORF in Assemblies 19, 20 and 21 72 orf19.72 Predicted ORF from Assembly 19; merged with orf19.4720 in Assembly 20 7200 orf19.7200 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 7202 orf19.7202 Predicted ORF in Assemblies 19, 20 and 21 7203 orf19.7203 Predicted ORF in Assemblies 19, 20 and 21 7204 orf19.7204 Predicted ORF in Assemblies 19, 20 and 21 7209 orf19.7209 Predicted ORF in Assemblies 19, 20 and 21; induced by nitric oxide in yhb1 mutant 721 orf19.721 Predicted ORF in Assemblies 19, 20 and 21 7210 orf19.7210 Predicted ORF in Assemblies 19, 20 and 21 7212 orf19.7212 Phosphorylated protein of unknown function; predicted ORF in Assemblies 19, 20 and 21 7213 orf19.7213 Putative ATP-dependent RNA helicase; fungal-specific (no human or murine homolog) 7214 orf19.7214 Similar to glucan 1,3-beta-glucosidase; regulated by Nrg1p, Tup1p; possibly regulated by Tac1p; induced upon biofilm formation; induced by nitric oxide; induced during cell wall regeneration; detected by mass spec in stationary phase 7215 orf19.7215 Predicted ORF in Assemblies 19, 20 and 21 7215.3 orf19.7215.3 ORF Predicted by Annotation Working Group 7216 orf19.7216 Predicted ORF in Assemblies 19, 20 and 21 7223 orf19.7223 Predicted ORF in Assemblies 19, 20 and 21 7224 orf19.7224 Predicted ORF in Assemblies 19, 20 and 21 7225 orf19.7225 Predicted ORF in Assemblies 19, 20 and 21 7227 orf19.7227 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to toxic ergosterol analog 7228 orf19.7228 Putative protein of unknown function, transcription is positively regulated by Tbf1p; predicted ORF in Assemblies 19, 20 and 21 7229 orf19.7229 Predicted ORF in Assemblies 19, 20 and 21 7233 orf19.7233 Predicted ORF from Assembly 19; merged with orf19.7232 in Assembly 20 7234 orf19.7234 Predicted ORF in Assemblies 19, 20 and 21 7235 orf19.7235 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to amphotericin B 7237 orf19.7237 Predicted ORF in Assemblies 19, 20 and 21 7239 orf19.7239 Predicted ORF in Assemblies 19, 20 and 21 7240 orf19.7240 Predicted ORF from Assembly 19; removed from Assembly 20 7243 orf19.7243 Predicted ORF in Assemblies 19, 20 and 21 7244 orf19.7244 Predicted ORF in Assemblies 19, 20 and 21; induced by nitric oxide in yhb1 mutant 7245 orf19.7245 Predicted ORF in Assemblies 19, 20 and 21 725 orf19.725 Predicted ORF in Assemblies 19, 20 and 21 7250 orf19.7250 Predicted ORF in Assemblies 19, 20 and 21 7252 orf19.7252 Predicted ORF in Assemblies 19, 20 and 21 7254 orf19.7254 Predicted ORF in Assemblies 19, 20 and 21 7256 orf19.7256 Predicted ORF from Assembly 19; flucytosine induced; removed from Assembly 20 7257 orf19.7257 Predicted ORF in Assemblies 19, 20 and 21 7260 orf19.7260 Predicted ORF in Assemblies 19, 20 and 21 7261 orf19.7261 Predicted ORF in Assemblies 19, 20 and 21 7263 orf19.7263 Predicted ORF in Assemblies 19, 20 and 21 7264 orf19.7264 Predicted ORF in Assemblies 19, 20 and 21 7265 orf19.7265 Predicted ORF in Assemblies 19, 20 and 21 7266 orf19.7266 Predicted ORF in Assemblies 19, 20 and 21 7267 orf19.7267 Predicted ORF in Assemblies 19, 20 and 21 7269 orf19.7269 Predicted ORF in Assemblies 19, 20 and 21 727 orf19.727 Predicted ORF in Assemblies 19, 20 and 21; member of a family encoded by FGR6-related genes in the RB2 repeat sequence; possibly spurious ORF (Annotation Working Group prediction) 7270 orf19.7270 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 7271 orf19.7271 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 7272 orf19.7272 Predicted ORF in Assemblies 19, 20 and 21 7273 orf19.7273 Predicted ORF from Assembly 19; merged with orf19.7274 in Assembly 20 7274 orf19.7274 Predicted ORF in retrotransposon Zorro2 with similarity to retroviral reverse transcriptase proteins 7277 orf19.7277 Predicted ORF in retrotransposon Zorro2 with similarity to zinc finger-containing retroviral nucleocapsid proteins; un-merged from orf19.7275 in a revision of Assembly 21 based on comparative genome analysis and new sequence data 7278 orf19.7278 Similar to a region of the Tca2 (pCal) retrotransposon, which is present in strain hOG1042 as 50 to 100 copies of a linear dsDNA 7279 orf19.7279 Predicted ORF in Assemblies 19, 20 and 21 7279.1 orf19.7279.1 ORF added to Assembly 21 based on comparative genome analysis 7280 orf19.7280 Predicted ORF in Assemblies 19, 20 and 21 7283 orf19.7283 Predicted ORF in Assemblies 19, 20 and 21 7285 orf19.7285 Predicted ORF in Assemblies 19, 20 and 21 7287 orf19.7287 Predicted ORF from Assembly 19; merged with orf19.7286 in Assembly 20 7288 orf19.7288 Predicted ORF in Assemblies 19, 20 and 21 7290 orf19.7290 Predicted ORF in Assemblies 19, 20 and 21 7291 orf19.7291 Protein not essential for viability 7294 orf19.7294 Predicted ORF from Assembly 19; removed from Assembly 20 7295 orf19.7295 Predicted ORF in Assemblies 19, 20 and 21 7296 orf19.7296 Predicted ORF in Assemblies 19, 20 and 21; similar to stomatin mechanoreception protein; induced by Rgt1p 7297 orf19.7297 Predicted ORF in Assemblies 19, 20 and 21; Hog1p-induced; Gcn4p-regulated; protein level decreased in stationary phase cultures 7299.1 orf19.7299.1 ORF Predicted by Annotation Working Group 73 orf19.73 Predicted ORF in Assemblies 19, 20 and 21 730 orf19.730 Predicted ORF in Assembly 20 and 21 (see Locus History); transcriptionally activated by Mnl1p under weak acid stress 7300 orf19.7300 Predicted ORF in Assemblies 19, 20 and 21 7301 orf19.7301 Predicted ORF in Assemblies 19, 20 and 21 7302 orf19.7302 Predicted ORF from Assembly 19; merged with orf19.7301 in Assembly 20 7303 orf19.7303 Predicted ORF in Assemblies 19, 20 and 21 7304 orf19.7304 Predicted ORF in Assemblies 19, 20 and 21 7305 orf19.7305 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 7306 orf19.7306 Protein of aldo-keto reductase family; increased transcription associated with MDR1 overexpression, benomyl or long-term fluconazole treatment; overexpression does not affect drug or oxidative stress sensitivity 7307 orf19.7307 Putative oxidoreductase; similar to S. cerevisiae Yml125p; possible Kex2p substrate 7310 orf19.7310 Protein similar to S. cerevisiae Gin3p; transcription is upregulated in response to treatment with ciclopirox olamine; positively regulated by Sfu1p; Hog1p, fluconazole-downregulated 7311 orf19.7311 Predicted ORF in Assemblies 19, 20 and 21 7316 orf19.7316 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine); induced by nitric oxide 7317 orf19.7317 Predicted zinc-finger protein of unknown function; has similarity to S. cerevisiae Uga3p, which is a transcription factor involved in the regulation of gamma-aminobutyrate metabolism genes 7318 orf19.7318 Putative transcription factor with zinc cluster DNA-binding motif; merged with orf19.7317 in Assembly 20 732 orf19.732 Predicted ORF in Assemblies 19, 20 and 21; transcription is upregulated in both intermediate and mature biofilms 7321 orf19.7321 Predicted ORF in Assemblies 19, 20 and 21 7322 orf19.7322 Predicted ORF in Assemblies 19, 20 and 21 7325 orf19.7325 Predicted ORF in Assemblies 19, 20 and 21 7326 orf19.7326 Predicted ORF in Assemblies 19, 20 and 21 7328 orf19.7328 Gene transcription regulated by Mig1p and Tup1p 7329 orf19.7329 Predicted ORF in Assemblies 19, 20 and 21 733 orf19.733 Predicted ORF in Assemblies 19, 20 and 21 7330 orf19.7330 Predicted ORF in Assemblies 19, 20 and 21 7336 orf19.7336 Predicted membrane transporter, member of the drug:proton antiporter (14 spanner) (DHA2) family, major facilitator superfamily (MFS) 7337 orf19.7337 Predicted ORF in Assemblies 19, 20 and 21 7340 orf19.7340 Predicted ORF in Assemblies 19, 20 and 21 7341 orf19.7341 Predicted ORF in Assemblies 19, 20 and 21; ketoconazole-repressed 7341.1 orf19.7341.1 ORF added to Assembly 21 based on comparative genome analysis 7343 orf19.7343 Predicted ORF in Assemblies 19, 20 and 21 7344 orf19.7344 Predicted ORF in Assemblies 19, 20 and 21 7345 orf19.7345 Predicted ORF in Assemblies 19, 20 and 21 7346 orf19.7346 Predicted ORF from Assembly 19; removed from Assembly 20 7347 orf19.7347 Predicted ORF in Assemblies 19, 20 and 21 7348 orf19.7348 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 735 orf19.735 Putative DNA-binding transcription factor; putative TFIID subunit; flucytosine repressed; merged with orf19.6193 in Assembly 20 7350 orf19.7350 Soluble protein in hyphae; fluconazole-induced; mRNA abundance is elevated in a cyr1 or ras1 null mutant and decreased mRNA abundance in an efg1 null mutant; regulated by Nrg1p, Tup1p, Tbf1p, Ssn6p 7353 orf19.7353 Predicted ORF in Assemblies 19, 20 and 21 7354 orf19.7354 Predicted ORF in Assemblies 19, 20 and 21; caspofungin induced 7356 orf19.7356 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 7357 orf19.7357 Predicted ORF in Assemblies 19, 20 and 21 7358 orf19.7358 Predicted ORF in Assemblies 19, 20 and 21 736 orf19.736 Predicted ORF in Assemblies 19, 20 and 21 7360 orf19.7360 Predicted ORF in Assemblies 19, 20 and 21 7361 orf19.7361 Predicted ORF in Assemblies 19, 20 and 21 7364 orf19.7364 Predicted ORF in Assemblies 19, 20 and 21 7365 orf19.7365 Predicted ORF in Assemblies 19, 20 and 21 7366 orf19.7366 Predicted ORF in Assemblies 19, 20 and 21 7368 orf19.7368 Predicted ORF in Assemblies 19, 20 and 21 7369 orf19.7369 Predicted ORF in Assemblies 19, 20 and 21 737 orf19.737 Predicted ORF from Assembly 19; removed from Assembly 20 7370 orf19.7370 Member of family of putative 7-transmembrane, PQ loop-family of G-protein-coupled receptors (GPCRs) similar to S. pombe Stm1p 7371 orf19.7371 Predicted zinc-cluster protein of unknown function 7373 orf19.7373 Predicted ORF from Assembly 19; removed from Assembly 20 7375 orf19.7375 Putative U1A component of the U1 snRNP, involved in splicing; contains two RNA recognition motifs (RRMs); ortholog of S. cerevisiae MUD1; predicted ORF in Assemblies 19, 20 and 21 7376 orf19.7376 Predicted ORF in Assemblies 19, 20 and 21 7378 orf19.7378 Predicted ORF in Assemblies 19, 20 and 21 7380 orf19.7380 Predicted ORF in Assemblies 19, 20 and 21 7385 orf19.7385 Predicted ORF in Assemblies 19, 20 and 21 7386 orf19.7386 Predicted ORF in Assemblies 19, 20 and 21 7387 orf19.7387 Predicted ORF in Assemblies 19, 20 and 21 7390 orf19.7390 Predicted ORF from Assembly 19; merged with orf19.7389 in Assembly 20 7392 orf19.7392 Predicted ORF in Assemblies 19, 20 and 21 7393 orf19.7393 Predicted ORF in Assemblies 19, 20 and 21 7395 orf19.7395 Predicted ORF in Assemblies 19, 20 and 21 7396 orf19.7396 Predicted ORF in Assemblies 19, 20 and 21 7397 orf19.7397 Predicted ORF in Assemblies 19, 20 and 21 7398 orf19.7398 Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins 7399 orf19.7399 ORF Predicted by Annotation Working Group; removed from Assembly 21 7402 orf19.7402 Predicted ORF in Assemblies 19, 20 and 21 7403 orf19.7403 Predicted ORF in Assemblies 19, 20 and 21 7404 orf19.7404 Predicted ORF in Assemblies 19, 20 and 21 7405 orf19.7405 Predicted ORF in Assemblies 19, 20 and 21; transcriptionally activated by Mnl1p under weak acid stress 7406 orf19.7406 Predicted ORF in Assemblies 19, 20 and 21 7409.1 orf19.7409.1 ORF Predicted by Annotation Working Group 741 orf19.741 Predicted ORF in Assemblies 19, 20 and 21 7410 orf19.7410 Protein not essential for viability 7420 orf19.7420 Predicted ORF in Assemblies 19, 20 and 21 7422 orf19.7422 Predicted ORF in Assemblies 19, 20 and 21 7425 orf19.7425 Predicted ORF in Assemblies 19, 20 and 21 7426 orf19.7426 Predicted ORF in Assemblies 19, 20 and 21 7427 orf19.7427 Predicted ORF in Assemblies 19, 20 and 21 7433 orf19.7433 Predicted ORF in Assemblies 19, 20 and 21 7435 orf19.7435 Predicted ORF from Assembly 19; removed from Assembly 20 7437 orf19.7437 Predicted ORF in Assemblies 19, 20 and 21 7441 orf19.7441 Predicted ORF in Assemblies 19, 20 and 21 7442 orf19.7442 Predicted ORF in Assemblies 19, 20 and 21 7443 orf19.7443 Predicted ORF in Assemblies 19, 20 and 21 7444 orf19.7444 Predicted ORF in Assemblies 19, 20 and 21 7445 orf19.7445 Predicted ORF in Assemblies 19, 20 and 21 7449 orf19.7449 Predicted ORF in Assemblies 19, 20 and 21 7450 orf19.7450 Predicted ORF in Assemblies 19, 20 and 21 7452 orf19.7452 Predicted ORF in Assemblies 19, 20 and 21 7453 orf19.7453 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 7455 orf19.7455 Predicted ORF in Assemblies 19, 20 and 21 7456 orf19.7456 Predicted ORF in Assemblies 19, 20 and 21 7457 orf19.7457 Predicted ORF in Assemblies 19, 20 and 21; shows Mob2p-dependent hyphal regulation 7458 orf19.7458 Predicted ORF in Assemblies 19, 20 and 21 7459 orf19.7459 Predicted ORF in Assemblies 19, 20 and 21; fluconazole-induced; ketoconazole-repressed 746 orf19.746 Predicted ORF in Assemblies 19, 20 and 21 7460 orf19.7460 Putative protein of unknown function, transcription is activated in the presence of elevated CO2; predicted ORF in Assemblies 19, 20 and 21 7463 orf19.7463 Predicted ORF in Assemblies 19, 20 and 21 7464 orf19.7464 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to toxic ergosterol analog 7468 orf19.7468 Predicted ORF in Assemblies 19, 20 and 21 7473 orf19.7473 Predicted ORF in Assemblies 19, 20 and 21 7478 orf19.7478 Predicted ORF in Assemblies 19, 20 and 21 748 orf19.748 Predicted ORF in Assemblies 19, 20 and 21 7480 orf19.7480 Putative protein of unknown function, transcription is upregulated in clinical isolates from HIV+ patients with oral candidiasis; predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 7482 orf19.7482 Predicted ORF in Assemblies 19, 20 and 21 7485 orf19.7485 Predicted ORF in Assemblies 19, 20 and 21 7487 orf19.7487 Predicted ORF in Assemblies 19, 20 and 21 7488 orf19.7488 Predicted ORF in Assemblies 19, 20 and 21 7489 orf19.7489 Predicted ORF in Assemblies 19, 20 and 21 7489.3 orf19.7489.3 ORF Predicted by Annotation Working Group 749 orf19.749 Protein likely to be essential for growth, based on an insertional mutagenesis strategy; merged with orf19.48 in Assembly 20 7490 orf19.7490 Predicted membrane transporter, member of the fucose:proton symporter (FHS) family, major facilitator superfamily (MFS) 7491 orf19.7491 Predicted ORF in Assemblies 19, 20 and 21 7494 orf19.7494 Predicted ORF in Assemblies 19, 20 and 21; cell-cycle regulated periodic mRNA expression 7495 orf19.7495 Predicted ORF in Assemblies 19, 20 and 21; induced by nitric oxide 7497 orf19.7497 Predicted ORF in Assemblies 19, 20 and 21 7499 orf19.7499 Putative nicotinic acid mononucleotide adenylyltransferase, involved in NAD salvage pathway 7499.1 orf19.7499.1 ORF added to Assembly 21 based on comparative genome analysis 75 orf19.75 Predicted exocyst component; ortholog of S. cerevisiae Sec5p; merged with orf19.74 in Assembly 21 750 orf19.750 Predicted ORF in Assemblies 19, 20 and 21; exogenously expressed protein is a substrate for Kex2p processing in vitro; possibly spurious ORF (Annotation Working Group prediction) 7501 orf19.7501 Predicted ORF in Assemblies 19, 20 and 21; protein detected by mass spec in exponential and stationary phase cultures 7502 orf19.7502 Predicted ORF in Assemblies 19, 20 and 21; greater mRNA abundance observed in a cyr1 homozygous null mutant than in wild type; possibly spurious ORF (Annotation Working Group prediction) 7504 orf19.7504 Predicted ORF in Assemblies 19, 20 and 21; Plc1p-regulated; induced in core caspofungin response 7505 orf19.7505 Predicted ORF from Assembly 19; removed from Assembly 20 7506 orf19.7506 Predicted ORF in Assemblies 19, 20 and 21 7507 orf19.7507 Predicted ORF in Assemblies 19, 20 and 21 751 orf19.751 Predicted ORF in Assemblies 19, 20 and 21 7511 orf19.7511 Predicted ORF in Assemblies 19, 20 and 21 7512 orf19.7512 Predicted ORF in Assemblies 19, 20 and 21 7513 orf19.7513 Predicted ORF in Assemblies 19, 20 and 21 7516 orf19.7516 Predicted ORF in Assemblies 19, 20 and 21 7518 orf19.7518 Putative transcription factor with zinc cluster DNA-binding motif 7519 orf19.7519 Predicted ORF in Assemblies 19, 20 and 21 752 orf19.752 Predicted ORF in Assemblies 19, 20 and 21 7522 orf19.7522 Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to amphotericin B 7527 orf19.7527 Predicted ORF in Assemblies 19, 20 and 21 753 orf19.753 Predicted ORF in Assemblies 19, 20 and 21 7531 orf19.7531 Predicted ORF in Assemblies 19, 20 and 21; transcription is induced upon yeast-hyphal transition; benomyl or caspofungin induced; protein detected by mass spec in stationary phase cultures 7538 orf19.7538 Predicted ORF in Assemblies 19, 20 and 21 7539.1 orf19.7539.1 Predicted ORF in Assemblies 19, 20 and 21 754 orf19.754 Predicted ORF in Assemblies 19, 20 and 21 7545 orf19.7545 Predicted ORF in Assemblies 19, 20 and 21; similarity to mutator-like element (MULE) transposase; possibly spurious ORF (Annotation Working Group prediction) 7546 orf19.7546 Predicted ORF in Assemblies 19, 20 and 21 7547 orf19.7547 Predicted ORF in Assemblies 19, 20 and 21 7548 orf19.7548 Predicted ORF in Assemblies 19, 20 and 21 7552 orf19.7552 Predicted ORF in Assemblies 19, 20 and 21; downregulated during core stress response 7553 orf19.7553 Predicted ORF in Assemblies 19, 20 and 21 7554 orf19.7554 Putative transporter; slightly similar to the Sit1p siderophore transporter; induced by nitric oxide in yhb1 mutant 7555 orf19.7555 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 7556 orf19.7556 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 7566 orf19.7566 Putative protein of unknown function, transcription is upregulated in clinical isolates from HIV+ patients with oral candidiasis; alkaline upregulated by Rim101p; fungal-specific (no human or murine homolog) 7567 orf19.7567 Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium 7568 orf19.7568 Predicted ORF in Assemblies 19, 20 and 21 757 orf19.757 Predicted ORF in Assemblies 19, 20 and 21 757.1 orf19.757.1 ORF added to Assembly 21 based on comparative genome analysis 7570 orf19.7570 Putative transcription factor with zinc cluster DNA-binding motif; has similarity to S. cerevisiae Uga3p, which is a transcription factor involved in the regulation of gamma-aminobutyrate metabolism genes 7574 orf19.7574 Predicted ORF in Assemblies 19, 20 and 21 7576 orf19.7576 Protein not essential for viability 7578 orf19.7578 Predicted ORF in Assemblies 19, 20 and 21 758 orf19.758 Predicted ORF in Assemblies 19, 20 and 21 7580 orf19.7580 Predicted ORF in Assemblies 19, 20 and 21 7581 orf19.7581 Predicted ORF in Assemblies 19, 20 and 21 7583 orf19.7583 Putative transcription factor with zinc cluster DNA-binding motif; not essential for viability; filament induced 7588 orf19.7588 Predicted ORF in Assemblies 19, 20 and 21 7589 orf19.7589 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction); transcription is activated in the presence of elevated CO2 759 orf19.759 Predicted ORF in Assemblies 19, 20 and 21 7590 orf19.7590 Protein described as NADH-ubiquinone oxidoreductase; identified in detergent-resistant membrane fraction (possible lipid raft component); predicted N-terminal acetylation; repressed by nitric oxide 7591 orf19.7591 Protein described as NADH-ubiquinone oxidoreductase; identified in detergent-resistant membrane fraction (possible lipid raft component); predicted N-terminal acetylation; repressed by nitric oxide; merged with orf19.7590 in Assembly 20 7593 orf19.7593 Predicted ORF in Assemblies 19, 20 and 21 7594 orf19.7594 Predicted ORF in Assemblies 19, 20 and 21 7595 orf19.7595 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 7596 orf19.7596 Predicted ORF in Assemblies 19, 20 and 21 7598 orf19.7598 Predicted ORF in Assemblies 19, 20 and 21 760 orf19.760 Predicted ORF in Assemblies 19, 20 and 21 7601 orf19.7601 Predicted ORF in Assemblies 19, 20 and 21 7602 orf19.7602 Predicted ORF in Assemblies 19, 20 and 21; heavy metal (cadmium) stress-induced; oxidative stress-induced via Cap1p 7603 orf19.7603 Predicted ORF in Assemblies 19, 20 and 21 7604 orf19.7604 Predicted ORF in Assemblies 19, 20 and 21 7606 orf19.7606 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 7608 orf19.7608 Predicted ORF in Assemblies 19, 20 and 21; fluconazole-downregulated; possibly spurious ORF (Annotation Working Group prediction) 7614 orf19.7614 Protein not essential for viability 7615 orf19.7615 Predicted ORF in Assemblies 19, 20 and 21 7617 orf19.7617 Predicted ORF in Assemblies 19, 20 and 21 7618 orf19.7618 Predicted ORF in Assemblies 19, 20 and 21; Plc1p-regulated 7619 orf19.7619 Predicted ORF in Assemblies 19, 20 and 21 762 orf19.762 Predicted ORF in Assemblies 19, 20 and 21 7620 orf19.7620 Predicted ORF in Assemblies 19, 20 and 21 7621 orf19.7621 Predicted ORF in Assemblies 19, 20 and 21 7624 orf19.7624 Predicted ORF in Assemblies 19, 20 and 21 7627 orf19.7627 Predicted ORF in Assemblies 19, 20 and 21 7629 orf19.7629 Predicted ORF in Assemblies 19, 20 and 21 763 orf19.763 Predicted ORF in Assemblies 19, 20 and 21 7632 orf19.7632 Predicted ORF in Assemblies 19, 20 and 21 764 orf19.764 Predicted ORF in Assemblies 19, 20 and 21 7642 orf19.7642 Predicted ORF in Assemblies 19, 20 and 21 7643 orf19.7643 Predicted ORF in Assemblies 19, 20 and 21 7644 orf19.7644 Predicted ORF in Assemblies 19, 20 and 21 7645 orf19.7645 Biotin protein ligase; catalyzes covalent attachment of biotin to biotin-dependent enzymes including acetyl CoA carboxylase and pyruvate carboxylase 7646 orf19.7646 Predicted ORF in Assemblies 19, 20 and 21 7648 orf19.7648 Predicted ORF in Assemblies 19, 20 and 21 765 orf19.765 Predicted ORF from Assembly 19; merged with orf19.764 in Assembly 20 7660 orf19.7660 Predicted ORF in Assemblies 19, 20 and 21 7662 orf19.7662 Predicted ORF in Assemblies 19, 20 and 21 7663 orf19.7663 Predicted ORF in Assemblies 19, 20 and 21 7664 orf19.7664 Predicted ORF in Assemblies 19, 20 and 21 7665 orf19.7665 Predicted ORF in Assemblies 19, 20 and 21 7666 orf19.7666 Predicted membrane transporter, member of the anion:cation symporter (ACS) family, major facilitator superfamily (MFS) 7670 orf19.7670 Putative Ca2+/H+ antiporter; fungal-specific (no human or murine homolog) 7672 orf19.7672 Predicted ORF in Assemblies 19, 20 and 21 7673 orf19.7673 Predicted ORF in Assemblies 19, 20 and 21 7674 orf19.7674 Predicted ORF from Assembly 19; removed from Assembly 20 7675 orf19.7675 ORF Predicted by Annotation Working Group 7678 orf19.7678 Predicted ORF in Assemblies 19, 20 and 21 77.1 orf19.77.1 ORF Predicted by Annotation Working Group 772.1 orf19.772.1 ORF added to Assembly 21 based on comparative genome analysis 773 orf19.773 Putative ortholog of S. cerevisiae Rsa3p, which is a nucleolar protein involved in maturation of pre-60S ribosomal particles that interacts with Dbp6p 775 orf19.775 Predicted ORF in Assemblies 19, 20 and 21 776 orf19.776 Predicted ORF in Assemblies 19, 20 and 21 779 orf19.779 Predicted ORF in Assemblies 19, 20 and 21 781 orf19.781 Putative urea transporter; fungal-specific (no human or murine homolog) 782 orf19.782 Predicted ORF in Assemblies 19, 20 and 21 783 orf19.783 Predicted ORF in Assemblies 19, 20 and 21 784 orf19.784 Predicted ORF from Assembly 19; merged with orf19.1813 in Assembly 20 785 orf19.785 Predicted ORF from Assembly 19; merged with orf19.1813 in Assembly 20 786 orf19.786 Predicted ORF from Assembly 19; removed from Assembly 20 787 orf19.787 Predicted ORF in Assemblies 19, 20 and 21 787.1 orf19.787.1 ORF added to Assembly 21 based on comparative genome analysis; protein detected by mass spec in stationary phase cultures 789.1 orf19.789.1 Predicted ORF in Assembly 20 and 21 79 orf19.79 Predicted ORF from Assembly 19; removed from Assembly 20 792 orf19.792 Predicted ORF in Assemblies 19, 20 and 21 794 orf19.794 Predicted ORF in Assemblies 19, 20 and 21 8 orf19.8 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 803 orf19.803 Predicted ORF from Assembly 19; merged with orf19.802 in Assembly 20; protein detected by mass spec in stationary phase cultures 804 orf19.804 Predicted ORF in Assemblies 19, 20 and 21 804.1 orf19.804.1 ORF added to Assembly 21 based on comparative genome analysis 805 orf19.805 Predicted ORF in Assemblies 19, 20 and 21 808 orf19.808 Predicted ORF in Assemblies 19, 20 and 21 809 orf19.809 Predicted ORF in Assemblies 19, 20 and 21 81 orf19.81 Predicted ORF in Assemblies 19, 20 and 21 810 orf19.810 Predicted ORF in Assemblies 19, 20 and 21 811 orf19.811 Protein not essential for viability 812 orf19.812 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 813 orf19.813 Predicted ORF in Assemblies 19, 20 and 21; not essential for viability; oxidative stress-induced via Cap1p; similar to S. cerevisiae Vhs3p, which is a putative phosphopantothenoylcysteine decarboxylase 814.3 orf19.814.3 ORF Predicted by Annotation Working Group; merged with orf19.814 in Assembly 20 819 orf19.819 Predicted ORF in Assemblies 19, 20 and 21 82 orf19.82 Predicted ORF from Assembly 19; merged with orf19.1296 in Assembly 20 822 orf19.822 Protein detected in some, not all, biofilm extracts; fluconazole-downregulated; greater mRNA abundance observed in cyr1 or ras1 homozygous null mutant than in wild type; protein detected by mass spec in stationary phase cultures 823 orf19.823 Predicted ORF in Assemblies 19, 20 and 21 826 orf19.826 Predicted ORF in Assemblies 19, 20 and 21 827 orf19.827 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 8278 orf19.8278 Predicted ORF from original SGTC Assembly 19 annotation, removed from the reduced ORF set by the SGTC; subsequently reinstated in Assembly 21 based on comparative genome analysis 828 orf19.828 Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins 83 orf19.83 Predicted ORF from Assembly 19; removed from Assembly 20 831 orf19.831 Predicted ORF in Assemblies 19, 20 and 21 833 orf19.833 Predicted ORF from Assembly 19; merged with orf19.832 in Assembly 20 834 orf19.834 Predicted ORF in Assemblies 19, 20 and 21 835 orf19.835 Predicted ORF in Assemblies 19, 20 and 21 836 orf19.836 Protein likely to be essential for growth, based on an insertional mutagenesis strategy 836.1 orf19.836.1 ORF Predicted by Annotation Working Group 839 orf19.839 Predicted ORF in Assemblies 19, 20 and 21; induced by nitric oxide in yhb1 mutant; mutation confers hypersensitivity to aureobasidin A 841 orf19.841 Predicted ORF in Assemblies 19, 20 and 21 843 orf19.843 Putative DNA repair exonuclease; fungal-specific (no human or murine homolog) 846 orf19.846 Predicted ORF in Assemblies 19, 20 and 21; transcriptionally activated by Mnl1p under weak acid stress 849 orf19.849 Predicted ORF in Assemblies 19, 20 and 21 850 orf19.850 Predicted ORF in Assemblies 19, 20 and 21 851 orf19.851 Protein of unknown function; transcription is negatively regulated by Rim101p 854.1 orf19.854.1 Region annotated in Assembly 21 as a blocked reading frame, based on comparative genome analysis; overlaps orf19.854, which is an open reading frame 855 orf19.855 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 859 orf19.859 Predicted ORF from Assembly 19; merged with orf19.857 in Assembly 20 86 orf19.86 Protein described as glutathione peroxidase; macrophage-downregulated gene 861 orf19.861 Predicted transcriptional regulator with bZip domain 862 orf19.862 Predicted ORF in Assemblies 19, 20 and 21 863 orf19.863 Predicted ORF in Assemblies 19, 20 and 21 864 orf19.864 Predicted ORF in Assemblies 19, 20 and 21 867 orf19.867 Predicted ORF in Assemblies 19, 20 and 21 871 orf19.871 Predicted ORF in Assemblies 19, 20 and 21 872 orf19.872 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 873 orf19.873 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 874 orf19.874 Predicted ORF in Assemblies 19, 20 and 21 875 orf19.875 Predicted ORF in Assemblies 19, 20 and 21 877 orf19.877 Predicted ORF from Assembly 19; removed from Assembly 20 879 orf19.879 Predicted ORF in Assemblies 19, 20 and 21 880 orf19.880 Predicted ORF in Assemblies 19, 20 and 21 8837 orf19.8837 Predicted ORF from Assembly 19; not essential for viability; removed from Assembly 20 884 orf19.884 Predicted ORF from Assembly 19; merged with orf19.882 in Assembly 20 89 orf19.89 Predicted ORF in Assemblies 19, 20 and 21 891 orf19.891 Predicted ORF in Assemblies 19, 20 and 21 894 orf19.894 Predicted ORF in Assemblies 19, 20 and 21 897 orf19.897 Predicted ORF in Assemblies 19, 20 and 21 8979 orf19.8979 Transcriptionally regulated by iron; expression greater in high iron; similar to GPI-linked cell-wall proteins; slight similarity to mucins; removed from Assembly 20 899 orf19.899 Predicted ORF in Assemblies 19, 20 and 21 9 orf19.9 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 90 orf19.90 Predicted ORF in Assemblies 19, 20 and 21 900 orf19.900 Predicted ORF in Assemblies 19, 20 and 21; protein detected by mass spec in stationary phase cultures 904 orf19.904 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 907 orf19.907 Predicted ORF from Assembly 19; merged with orf19.908 in Assembly 20 909.1 orf19.909.1 Predicted ORF in Assembly 20 and 21; gene has intron 91 orf19.91 Predicted ORF in Assemblies 19, 20 and 21 910 orf19.910 Predicted ORF in Assemblies 19, 20 and 21 911 orf19.911 Predicted ORF from Assembly 19; merged with orf19.5776 in Assembly 20 912 orf19.912 Predicted ORF from Assembly 19; merged with orf19.5776 in Assembly 20 913.2 orf19.913.2 ORF Predicted by Annotation Working Group 914 orf19.914 Predicted ORF from Assembly 19; removed from Assembly 20 915 orf19.915 Predicted ORF in Assemblies 19, 20 and 21 916 orf19.916 Predicted ORF in Assemblies 19, 20 and 21 917 orf19.917 Predicted ORF from Assembly 19; repressed by nitric oxide; removed from Assembly 20 919 orf19.919 Predicted ORF from Assembly 19; orf19.918 and orf19.919 may be a single ORF encoding a putative transporter of the PDR subfamily of the ABC protein family; merged with orf19.918 in Assembly 20 92 orf19.92 Predicted ORF in Assemblies 19, 20 and 21; increased expression in response to prostaglandins 921 orf19.921 Predicted ORF in Assemblies 19, 20 and 21 924 orf19.924 Predicted ORF from Assembly 19; removed from Assembly 20 925 orf19.925 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 927 orf19.927 Predicted ORF in Assemblies 19, 20 and 21 928 orf19.928 Predicted ORF in Assemblies 19, 20 and 21 929 orf19.929 Predicted ORF in Assemblies 19, 20 and 21 93 orf19.93 Predicted ORF in Assemblies 19, 20 and 21; shows colony morphology-related gene regulation by Ssn6p 931 orf19.931 Predicted ORF in Assemblies 19, 20 and 21 932 orf19.932 Predicted ORF in Assemblies 19, 20 and 21; merged with orf19.2226 in Assembly 21 933 orf19.933 Predicted ORF in Assemblies 19, 20 and 21; merged with orf19.2225 in Assembly 21 934 orf19.934 Predicted ORF from Assembly 19; removed from Assembly 20; subsequently reinstated in Assembly 21 and merged with orf19.2224, based on comparative genome analysis 936 orf19.936 Predicted ORF in Assemblies 19, 20 and 21 937 orf19.937 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 938 orf19.938 Predicted ORF in Assemblies 19, 20 and 21 94 orf19.94 Predicted ORF in Assemblies 19, 20 and 21 948 orf19.948 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 949 orf19.949 Predicted ORF in Assemblies 19, 20 and 21 95 orf19.95 Predicted ORF in Assemblies 19, 20 and 21 951 orf19.951 Predicted ORF in Assemblies 19, 20 and 21; transcription downregulated upon yeast-hyphal switch; fluconazole-induced; possibly spurious ORF (Annotation Working Group prediction) 952 orf19.952 Predicted ORF in Assemblies 19, 20 and 21 954 orf19.954 Predicted ORF in Assemblies 19, 20 and 21 955 orf19.955 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 956 orf19.956 Predicted ORF in Assemblies 19, 20 and 21 961.2 orf19.961.2 ORF Predicted by Annotation Working Group 962 orf19.962 Predicted ORF in Assemblies 19, 20 and 21 966 orf19.966 Predicted ORF in Assemblies 19, 20 and 21 967 orf19.967 Predicted ORF in Assemblies 19, 20 and 21 969 orf19.969 Predicted ORF in Assemblies 19, 20 and 21 970 orf19.970 Predicted ORF in Assemblies 19, 20 and 21 972 orf19.972 Predicted ORF in Assemblies 19, 20 and 21 975 orf19.975 Predicted ORF from Assembly 19; removed from Assembly 20 980 orf19.980 Predicted ORF in Assemblies 19, 20 and 21 981 orf19.981 Predicted ORF from Assembly 19; merged with orf19.4911 in Assembly 20 983 orf19.983 Predicted ORF from Assembly 19; merged with orf19.4912 in Assembly 20 985 orf19.985 Predicted ORF in Assemblies 19, 20 and 21 988 orf19.988 Predicted ORF in Assemblies 19, 20 and 21; fungal-specific (no human or murine homolog); transcription is upregulated in clinical isolates from HIV+ patients with oral candidiasis; possibly transcriptionally regulated upon hyphal formation 989 orf19.989 Predicted ORF in Assemblies 19, 20 and 21 993 orf19.993 Predicted ORF in Assemblies 19, 20 and 21 994 orf19.994 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction); transcriptionally activated by Mnl1p under weak acid stress 996 orf19.996 Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction) 997 orf19.997 Predicted ORF in Assemblies 19, 20 and 21 998 orf19.998 Protein not essential for viability