format-version: 1.2 subsetdef: goantislim_grouping "Grouping classes that can be excluded" subsetdef: gocheck_do_not_annotate "Term not to be used for direct annotation" subsetdef: gocheck_do_not_manually_annotate "Term not to be used for direct manual annotation" subsetdef: goslim_aspergillus "Aspergillus GO slim" subsetdef: goslim_candida "Candida GO slim" subsetdef: goslim_chembl "ChEMBL protein targets summary" subsetdef: goslim_generic "Generic GO slim" subsetdef: goslim_goa "GOA and proteome slim" subsetdef: goslim_metagenomics "Metagenomics GO slim" subsetdef: goslim_pir "PIR GO slim" subsetdef: goslim_plant "Plant GO slim" subsetdef: goslim_pombe "Fission yeast GO slim" subsetdef: goslim_synapse "synapse GO slim" subsetdef: goslim_virus "Viral GO slim" subsetdef: goslim_yeast "Yeast GO slim" subsetdef: gosubset_prok "Prokaryotic GO subset" subsetdef: mf_needs_review "Catalytic activity terms in need of attention" subsetdef: termgenie_unvetted "Terms created by TermGenie that do not follow a template and require additional vetting by editors" subsetdef: virus_checked "Viral overhaul terms" synonymtypedef: systematic_synonym "Systematic synonym" EXACT ontology: go/subsets/goslim_candida [Term] id: GO:0000746 name: conjugation namespace: biological_process def: "The union or introduction of genetic information from compatible mating types that results in a genetically different individual. Conjugation requires direct cellular contact between the organisms." [GOC:elh] subset: goslim_aspergillus subset: goslim_candida subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast subset: gosubset_prok xref: Wikipedia:Conjugation is_a: GO:0008150 ! biological_process [Term] id: GO:0000910 name: cytokinesis namespace: biological_process alt_id: GO:0007104 alt_id: GO:0016288 alt_id: GO:0033205 def: "The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells." [GOC:mtg_cell_cycle] comment: Note that when annotating eukaryotic species, mitotic or meiotic cytokinesis should always be specified for manual annotation and for prokaryotic species use 'FtsZ-dependent cytokinesis ; GO:0043093' or Cdv-dependent cytokinesis ; GO:0061639. Also, note that cytokinesis does not necessarily result in physical separation and detachment of the two daughter cells from each other. subset: gocheck_do_not_manually_annotate subset: goslim_aspergillus subset: goslim_candida subset: goslim_yeast subset: gosubset_prok synonym: "cell cycle cytokinesis" EXACT [] synonym: "cytokinesis involved in cell cycle" EXACT [GOC:dph, GOC:tb] xref: Reactome:REACT_101918 "Mitotic Telophase /Cytokinesis, Mus musculus" xref: Reactome:REACT_108805 "Mitotic Telophase /Cytokinesis, Dictyostelium discoideum" xref: Reactome:REACT_1932 "Mitotic Telophase /Cytokinesis, Homo sapiens" xref: Reactome:REACT_30667 "Mitotic Telophase /Cytokinesis, Schizosaccharomyces pombe" xref: Reactome:REACT_32636 "Mitotic Telophase /Cytokinesis, Bos taurus" xref: Reactome:REACT_78494 "Mitotic Telophase /Cytokinesis, Danio rerio" xref: Reactome:REACT_84722 "Mitotic Telophase /Cytokinesis, Gallus gallus" xref: Reactome:REACT_87726 "Mitotic Telophase /Cytokinesis, Xenopus tropicalis" xref: Reactome:REACT_92849 "Mitotic Telophase /Cytokinesis, Taeniopygia guttata" xref: Reactome:REACT_93374 "Mitotic Telophase /Cytokinesis, Canis familiaris" xref: Reactome:REACT_94382 "Mitotic Telophase /Cytokinesis, Drosophila melanogaster" xref: Reactome:REACT_98952 "Mitotic Telophase /Cytokinesis, Rattus norvegicus" xref: Reactome:REACT_99118 "Mitotic Telophase /Cytokinesis, Caenorhabditis elegans" xref: Wikipedia:Cytokinesis is_a: GO:0008150 ! biological_process relationship: has_part GO:0008150 ! biological_process relationship: part_of GO:0007049 ! cell cycle [Term] id: GO:0000988 name: transcription factor activity, protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. This term does not provide specificity with respect to the type of protein binding, e.g. transcription factor binding or RNA polymerase binding. Please use a child term that provides that specificity or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_yeast synonym: "protein binding transcription factor activity" EXACT [] synonym: "transcription factor activity" BROAD [] is_a: GO:0003674 ! molecular_function relationship: has_part GO:0005515 ! protein binding relationship: part_of GO:0050789 ! regulation of biological process created_by: kchris creation_date: 2010-08-10T04:03:22Z [Term] id: GO:0001411 name: hyphal tip namespace: cellular_component def: "The end, or tip, of a fungal hypha, where polarized growth occurs during hyphal elongation." [GOC:mcc] subset: goslim_candida is_a: GO:0030427 ! site of polarized growth [Term] id: GO:0003674 name: molecular_function namespace: molecular_function alt_id: GO:0005554 def: "Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions." [GOC:go_curators] comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. Note that when this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "molecular function" EXACT [] [Term] id: GO:0003677 name: DNA binding namespace: molecular_function def: "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "microtubule/chromatin interaction" RELATED [] synonym: "plasmid binding" NARROW [] is_a: GO:0003674 ! molecular_function [Term] id: GO:0003723 name: RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: Reactome:REACT_101703 "Exportin-5 recognizes 3' overhang of pre-miRNA, Xenopus tropicalis" xref: Reactome:REACT_103323 "Exportin-5 recognizes 3' overhang of pre-miRNA, Dictyostelium discoideum" xref: Reactome:REACT_106430 "Exportin-5 recognizes 3' overhang of pre-miRNA, Mus musculus" xref: Reactome:REACT_107757 "Exportin-5 recognizes 3' overhang of pre-miRNA, Drosophila melanogaster" xref: Reactome:REACT_108232 "Exportin-5 recognizes 3' overhang of pre-miRNA, Oryza sativa" xref: Reactome:REACT_108368 "Exportin-5 recognizes 3' overhang of pre-miRNA, Saccharomyces cerevisiae" xref: Reactome:REACT_109723 "Exportin-5 recognizes 3' overhang of pre-miRNA, Arabidopsis thaliana" xref: Reactome:REACT_12458 "Exportin-5 recognizes 3' overhang of pre-miRNA, Homo sapiens" xref: Reactome:REACT_29965 "Exportin-5 recognizes 3' overhang of pre-miRNA, Canis familiaris" xref: Reactome:REACT_77167 "Exportin-5 recognizes 3' overhang of pre-miRNA, Gallus gallus" xref: Reactome:REACT_78197 "Exportin-5 recognizes 3' overhang of pre-miRNA, Sus scrofa" xref: Reactome:REACT_87164 "Exportin-5 recognizes 3' overhang of pre-miRNA, Schizosaccharomyces pombe" xref: Reactome:REACT_89329 "Exportin-5 recognizes 3' overhang of pre-miRNA, Rattus norvegicus" xref: Reactome:REACT_90531 "Exportin-5 recognizes 3' overhang of pre-miRNA, Danio rerio" xref: Reactome:REACT_98683 "Exportin-5 recognizes 3' overhang of pre-miRNA, Taeniopygia guttata" is_a: GO:0003674 ! molecular_function [Term] id: GO:0003774 name: motor activity namespace: molecular_function def: "Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, GOC:vw, ISBN:0815316194, PMID:11242086] subset: goslim_aspergillus subset: goslim_candida subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: gosubset_prok is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0004386 name: helicase activity namespace: molecular_function def: "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] comment: Note that most helicases catalyze processive duplex unwinding. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast subset: gosubset_prok xref: Reactome:REACT_101111 "Addition of the third nucleotide on the nascent transcript, Saccharomyces cerevisiae" xref: Reactome:REACT_101247 "Formation of open bubble structure in DNA by helicases, Bos taurus" xref: Reactome:REACT_101622 "MCM8 mediated fork unwinding, Danio rerio" xref: Reactome:REACT_101644 "Formation of open bubble structure in DNA by helicases, Oryza sativa" xref: Reactome:REACT_101823 "MCM2-7 mediated fork unwinding, Plasmodium falciparum" xref: Reactome:REACT_101994 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Xenopus tropicalis" xref: Reactome:REACT_102121 "Addition of the third nucleotide on the nascent transcript, Rattus norvegicus" xref: Reactome:REACT_102441 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Gallus gallus" xref: Reactome:REACT_102560 "MCM2-7 mediated fork unwinding, Oryza sativa" xref: Reactome:REACT_1033 "Formation of open bubble structure in DNA by helicases, Homo sapiens" xref: Reactome:REACT_103861 "MCM8 mediated fork unwinding, Bos taurus" xref: Reactome:REACT_103881 "RNA Polymerase II Promoter Opening: First Transition, Dictyostelium discoideum" xref: Reactome:REACT_103897 "MCM8 mediated fork unwinding, Mus musculus" xref: Reactome:REACT_103959 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Rattus norvegicus" xref: Reactome:REACT_104221 "MCM2-7 mediated fork unwinding, Rattus norvegicus" xref: Reactome:REACT_105950 "MCM2-7 mediated fork unwinding, Xenopus tropicalis" xref: Reactome:REACT_106346 "Formation of open bubble structure in DNA by helicases, Taeniopygia guttata" xref: Reactome:REACT_107072 "Formation of open bubble structure in DNA by helicases, Mus musculus" xref: Reactome:REACT_107495 "RNA Polymerase II Promoter Opening: First Transition, Taeniopygia guttata" xref: Reactome:REACT_108159 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Dictyostelium discoideum" xref: Reactome:REACT_108648 "Addition of the third nucleotide on the nascent transcript, Arabidopsis thaliana" xref: Reactome:REACT_108654 "MCM2-7 mediated fork unwinding, Schizosaccharomyces pombe" xref: Reactome:REACT_109035 "RNA Polymerase II Promoter Opening: First Transition, Schizosaccharomyces pombe" xref: Reactome:REACT_109161 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Arabidopsis thaliana" xref: Reactome:REACT_110588 "MCM8 mediated fork unwinding, Xenopus tropicalis" xref: Reactome:REACT_110827 "Formation of open bubble structure in DNA by helicases, Danio rerio" xref: Reactome:REACT_110845 "Cap-bound mRNA is activated by helicases, Mus musculus" xref: Reactome:REACT_112208 "MCM8 mediated fork unwinding, Drosophila melanogaster" xref: Reactome:REACT_112817 "Cap-bound mRNA is activated by helicases, Schizosaccharomyces pombe" xref: Reactome:REACT_113177 "Formation of open bubble structure in DNA by helicases, Caenorhabditis elegans" xref: Reactome:REACT_1521 "Cap-bound mRNA is activated by helicases, Homo sapiens" xref: Reactome:REACT_1817 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Homo sapiens" xref: Reactome:REACT_1844 "RNA Polymerase II Promoter Opening: First Transition, Homo sapiens" xref: Reactome:REACT_28131 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Drosophila melanogaster" xref: Reactome:REACT_28343 "MCM2-7 mediated fork unwinding, Danio rerio" xref: Reactome:REACT_28810 "Addition of the third nucleotide on the nascent transcript, Oryza sativa" xref: Reactome:REACT_28880 "MCM2-7 mediated fork unwinding, Drosophila melanogaster" xref: Reactome:REACT_29155 "Addition of the third nucleotide on the nascent transcript, Drosophila melanogaster" xref: Reactome:REACT_29217 "Formation of open bubble structure in DNA by helicases, Xenopus tropicalis" xref: Reactome:REACT_29818 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Oryza sativa" xref: Reactome:REACT_29850 "RNA Polymerase II Promoter Opening: First Transition, Saccharomyces cerevisiae" xref: Reactome:REACT_30013 "MCM8 mediated fork unwinding, Rattus norvegicus" xref: Reactome:REACT_30989 "MCM8 mediated fork unwinding, Arabidopsis thaliana" xref: Reactome:REACT_31034 "Cap-bound mRNA is activated by helicases, Danio rerio" xref: Reactome:REACT_31090 "MCM2-7 mediated fork unwinding, Gallus gallus" xref: Reactome:REACT_31554 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Schizosaccharomyces pombe" xref: Reactome:REACT_32533 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Caenorhabditis elegans" xref: Reactome:REACT_33205 "MCM8 mediated fork unwinding, Canis familiaris" xref: Reactome:REACT_34016 "Formation of open bubble structure in DNA by helicases, Rattus norvegicus" xref: Reactome:REACT_34089 "MCM2-7 mediated fork unwinding, Dictyostelium discoideum" xref: Reactome:REACT_34560 "MCM8 mediated fork unwinding, Sus scrofa" xref: Reactome:REACT_40 "Addition of the third nucleotide on the nascent transcript, Homo sapiens" xref: Reactome:REACT_6134 "HIV-1 Promoter Opening: First Transition, Homo sapiens" xref: Reactome:REACT_6184 "Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition, Homo sapiens" xref: Reactome:REACT_6325 "Addition of the third nucleotide on the nascent HIV-1 transcript, Homo sapiens" xref: Reactome:REACT_6758 "Xenopus Mcm8 mediated fork unwinding, Xenopus laevis" xref: Reactome:REACT_6768 "MCM8 mediated fork unwinding, Homo sapiens" xref: Reactome:REACT_6853 "Yeast Mcm2-7 mediated fork unwinding, Saccharomyces cerevisiae" xref: Reactome:REACT_6922 "MCM2-7 mediated fork unwinding, Homo sapiens" xref: Reactome:REACT_78086 "RNA Polymerase II Promoter Opening: First Transition, Rattus norvegicus" xref: Reactome:REACT_78462 "Formation of open bubble structure in DNA by helicases, Drosophila melanogaster" xref: Reactome:REACT_78667 "MCM2-7 mediated fork unwinding, Canis familiaris" xref: Reactome:REACT_78771 "MCM8 mediated fork unwinding, Dictyostelium discoideum" xref: Reactome:REACT_79759 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Mus musculus" xref: Reactome:REACT_80107 "RNA Polymerase II Promoter Opening: First Transition, Arabidopsis thaliana" xref: Reactome:REACT_80325 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Danio rerio" xref: Reactome:REACT_80500 "MCM8 mediated fork unwinding, Gallus gallus" xref: Reactome:REACT_80532 "Addition of the third nucleotide on the nascent transcript, Gallus gallus" xref: Reactome:REACT_80605 "Addition of the third nucleotide on the nascent transcript, Mus musculus" xref: Reactome:REACT_81126 "Addition of the third nucleotide on the nascent transcript, Schizosaccharomyces pombe" xref: Reactome:REACT_81335 "RNA Polymerase II Promoter Opening: First Transition, Gallus gallus" xref: Reactome:REACT_81427 "MCM8 mediated fork unwinding, Taeniopygia guttata" xref: Reactome:REACT_81441 "MCM8 mediated fork unwinding, Oryza sativa" xref: Reactome:REACT_81682 "Formation of open bubble structure in DNA by helicases, Canis familiaris" xref: Reactome:REACT_82776 "RNA Polymerase II Promoter Opening: First Transition, Danio rerio" xref: Reactome:REACT_83794 "Formation of open bubble structure in DNA by helicases, Gallus gallus" xref: Reactome:REACT_84565 "Formation of open bubble structure in DNA by helicases, Schizosaccharomyces pombe" xref: Reactome:REACT_84574 "Cap-bound mRNA is activated by helicases, Canis familiaris" xref: Reactome:REACT_84809 "MCM2-7 mediated fork unwinding, Mus musculus" xref: Reactome:REACT_84907 "MCM2-7 mediated fork unwinding, Taeniopygia guttata" xref: Reactome:REACT_85111 "Cap-bound mRNA is activated by helicases, Drosophila melanogaster" xref: Reactome:REACT_85172 "MCM2-7 mediated fork unwinding, Arabidopsis thaliana" xref: Reactome:REACT_86220 "MCM2-7 mediated fork unwinding, Caenorhabditis elegans" xref: Reactome:REACT_88362 "Addition of the third nucleotide on the nascent transcript, Caenorhabditis elegans" xref: Reactome:REACT_89000 "MCM2-7 mediated fork unwinding, Bos taurus" xref: Reactome:REACT_89030 "Formation of open bubble structure in DNA by helicases, Saccharomyces cerevisiae" xref: Reactome:REACT_89363 "Addition of the third nucleotide on the nascent transcript, Xenopus tropicalis" xref: Reactome:REACT_89694 "RNA Polymerase II Promoter Opening: First Transition, Drosophila melanogaster" xref: Reactome:REACT_91822 "MCM8 mediated fork unwinding, Plasmodium falciparum" xref: Reactome:REACT_93391 "RNA Polymerase II Promoter Opening: First Transition, Oryza sativa" xref: Reactome:REACT_93711 "RNA Polymerase II Promoter Opening: First Transition, Mus musculus" xref: Reactome:REACT_94645 "RNA Polymerase II Promoter Opening: First Transition, Xenopus tropicalis" xref: Reactome:REACT_94679 "RNA Polymerase II Promoter Opening: First Transition, Caenorhabditis elegans" xref: Reactome:REACT_95942 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Saccharomyces cerevisiae" xref: Reactome:REACT_95993 "Formation of open bubble structure in DNA by helicases, Arabidopsis thaliana" xref: Reactome:REACT_98273 "Addition of the third nucleotide on the nascent transcript, Dictyostelium discoideum" xref: Reactome:REACT_98302 "Formation of open bubble structure in DNA by helicases, Sus scrofa" xref: Reactome:REACT_98745 "Cap-bound mRNA is activated by helicases, Xenopus tropicalis" xref: Reactome:REACT_99120 "Addition of the third nucleotide on the nascent transcript, Danio rerio" is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0004672 name: protein kinase activity namespace: molecular_function alt_id: GO:0050222 def: "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] comment: Note that triphosphate is used as a phosphate donor by at least one kinase. subset: goslim_aspergillus subset: goslim_candida subset: goslim_metagenomics subset: gosubset_prok synonym: "protamine kinase activity" NARROW [] xref: MetaCyc:PROTEIN-KINASE-RXN xref: Reactome:REACT_100389 "Phosphorylation and Release of IRF3 or IRF7, Bos taurus" xref: Reactome:REACT_100723 "Phosphorylation of p130Cas by SRC-FADK1 complex, Canis familiaris" xref: Reactome:REACT_100866 "Phosphorylation and activation of Ezrin, Gallus gallus" xref: Reactome:REACT_101171 "Phosphorylation and release of IRF3/IRF7, Rattus norvegicus" xref: Reactome:REACT_101316 "Autophosphorylation of FADK1 at Y397, Rattus norvegicus" xref: Reactome:REACT_102340 "Activated Src activates ERK, Danio rerio" xref: Reactome:REACT_102368 "Phosphorylation and Release of IRF3 or IRF7, Gallus gallus" xref: Reactome:REACT_104931 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Gallus gallus" xref: Reactome:REACT_104987 "Phosphorylation of pFADK1 by SRC, Danio rerio" xref: Reactome:REACT_105344 "Phosphorylation of p130Cas by SRC-FADK1 complex, Sus scrofa" xref: Reactome:REACT_106425 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Taeniopygia guttata" xref: Reactome:REACT_106633 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Sus scrofa" xref: Reactome:REACT_107161 "Phosphorylation and release of IRF3/IRF7, Taeniopygia guttata" xref: Reactome:REACT_107646 "Phosphorylation and release of IRF3/IRF7, Canis familiaris" xref: Reactome:REACT_107914 "(Frs2)Rap1-GTP binds to and activates B-Raf, Xenopus tropicalis" xref: Reactome:REACT_108319 "Activated Src activates ERK, Xenopus tropicalis" xref: Reactome:REACT_108693 "Phosphorylation and release of IRF3/IRF7, Mus musculus" xref: Reactome:REACT_109624 "Phosphorylation of p130Cas by SRC-FADK1 complex, Rattus norvegicus" xref: Reactome:REACT_110105 "Phosphorylation and activation of Ezrin, Canis familiaris" xref: Reactome:REACT_110177 "Autophosphorylation of FADK1 at Y397, Mus musculus" xref: Reactome:REACT_110248 "Activated Src activates ERK, Canis familiaris" xref: Reactome:REACT_111075 "Phosphorylation of LIN52 component of MuvB by DYRK1A, Homo sapiens" xref: Reactome:REACT_111995 "Phosphorylation of p130Cas by SRC-FADK1 complex, Drosophila melanogaster" xref: Reactome:REACT_112267 "Autophosphorylation of FADK1 at Y397, Drosophila melanogaster" xref: Reactome:REACT_112918 "Phosphorylation and activation of Ezrin, Caenorhabditis elegans" xref: Reactome:REACT_113100 "Activated Src activates ERK, Drosophila melanogaster" xref: Reactome:REACT_113334 "PKC phosphorylates GRK2, Caenorhabditis elegans" xref: Reactome:REACT_113440 "Phosphorylation and release of IRF3/IRF7, Xenopus tropicalis" xref: Reactome:REACT_113589 "Phosphorylation of pFADK1 by SRC, Drosophila melanogaster" xref: Reactome:REACT_113821 "Activated Src activates ERK, Caenorhabditis elegans" xref: Reactome:REACT_114093 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Danio rerio" xref: Reactome:REACT_114693 "Phosphorylation of pFADK1 by SRC, Xenopus tropicalis" xref: Reactome:REACT_115673 "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR, Homo sapiens" xref: Reactome:REACT_115712 "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers, Homo sapiens" xref: Reactome:REACT_115868 "Phosphorylation of c-Abl and Arg by ATM, Gallus gallus" xref: Reactome:REACT_116057 "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1, Homo sapiens" xref: Reactome:REACT_116116 "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3, Homo sapiens" xref: Reactome:REACT_12050 "(Frs2)Rap1-GTP binds to and activates B-Raf, Homo sapiens" xref: Reactome:REACT_1325 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Homo sapiens" xref: Reactome:REACT_15368 "Phosphorylation of pFADK1 by SRC, Homo sapiens" xref: Reactome:REACT_15375 "Phosphorylation of p130Cas by SRC-FADK1 complex, Homo sapiens" xref: Reactome:REACT_15534 "PKC phosphorylates GRK2, Homo sapiens" xref: Reactome:REACT_15535 "Autophosphorylation of FADK1 at Y397, Homo sapiens" xref: Reactome:REACT_161 "rLkb-1 (Stk-11) activates AMPK by phosphorylation, Rattus norvegicus" xref: Reactome:REACT_1825 "INF-gamma induced phosphorylation of L13a, Homo sapiens" xref: Reactome:REACT_19374 "Phosphorylation of Plexin-A, Mus musculus" xref: Reactome:REACT_22301 "Phosphorylation and activation of Ezrin, Homo sapiens" xref: Reactome:REACT_22305 "Phosphorylation of FADK1, Mus musculus" xref: Reactome:REACT_23900 "Activated Src activates ERK, Homo sapiens" xref: Reactome:REACT_24935 "Activation of IKK by MEKK1, Homo sapiens" xref: Reactome:REACT_25200 "IRAK1 phosphorylates Pellino, Homo sapiens" xref: Reactome:REACT_25213 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:Mal:activated TLR complex, Homo sapiens" xref: Reactome:REACT_25241 "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation, Homo sapiens" xref: Reactome:REACT_25327 "Phosphorylation and release of IRF7, Homo sapiens" xref: Reactome:REACT_25368 "Phosphorylation and release of IRF3/IRF7, Homo sapiens" xref: Reactome:REACT_27151 "Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR, Homo sapiens" xref: Reactome:REACT_27163 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex, Homo sapiens" xref: Reactome:REACT_27165 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex, Homo sapiens" xref: Reactome:REACT_27228 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR, Homo sapiens" xref: Reactome:REACT_29590 "PKC phosphorylates GRK2, Rattus norvegicus" xref: Reactome:REACT_29816 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Drosophila melanogaster" xref: Reactome:REACT_30885 "Phosphorylation of p130Cas by SRC-FADK1 complex, Bos taurus" xref: Reactome:REACT_31028 "Autophosphorylation of FADK1 at Y397, Sus scrofa" xref: Reactome:REACT_31157 "Phosphorylation of pFADK1 by SRC, Canis familiaris" xref: Reactome:REACT_31403 "Autophosphorylation of FADK1 at Y397, Gallus gallus" xref: Reactome:REACT_32448 "Phosphorylation of pFADK1 by SRC, Bos taurus" xref: Reactome:REACT_32744 "PKC phosphorylates GRK2, Mus musculus" xref: Reactome:REACT_33098 "PKC phosphorylates GRK2, Canis familiaris" xref: Reactome:REACT_33973 "Phosphorylation and Release of IRF3 or IRF7, Canis familiaris" xref: Reactome:REACT_34630 "(Frs2)Rap1-GTP binds to and activates B-Raf, Danio rerio" xref: Reactome:REACT_6227 "Activated DTOR also phosphorylates D4EBP, Drosophila melanogaster" xref: Reactome:REACT_6236 "Activated DTOR phosphorylates DS6K, Drosophila melanogaster" xref: Reactome:REACT_6842 "Phosphorylation and Release of IRF3 or IRF7, Homo sapiens" xref: Reactome:REACT_6862 "Multiple IRAK1 autophosphorylation steps, Homo sapiens" xref: Reactome:REACT_72123 "PKC phosphorylates GRK2, Sus scrofa" xref: Reactome:REACT_75763 "Phosphorylation and release of IRF3, Gallus gallus" xref: Reactome:REACT_75767 "Phosphorylation of IKKs complex mediated by MEKK1, Gallus gallus" xref: Reactome:REACT_77320 "Phosphorylation and release of IRF3/IRF7, Gallus gallus" xref: Reactome:REACT_77352 "Phosphorylation of p130Cas by SRC-FADK1 complex, Danio rerio" xref: Reactome:REACT_78568 "Phosphorylation and activation of Ezrin, Danio rerio" xref: Reactome:REACT_79546 "Activated Src activates ERK, Gallus gallus" xref: Reactome:REACT_80382 "Phosphorylation and activation of Ezrin, Mus musculus" xref: Reactome:REACT_81116 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Canis familiaris" xref: Reactome:REACT_81601 "Autophosphorylation of FADK1 at Y397, Bos taurus" xref: Reactome:REACT_81960 "PKC phosphorylates GRK2, Drosophila melanogaster" xref: Reactome:REACT_82440 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Xenopus tropicalis" xref: Reactome:REACT_82942 "Activated Src activates ERK, Bos taurus" xref: Reactome:REACT_83498 "Activated Src activates ERK, Taeniopygia guttata" xref: Reactome:REACT_83992 "(Frs2)Rap1-GTP binds to and activates B-Raf, Mus musculus" xref: Reactome:REACT_84298 "Autophosphorylation of FADK1 at Y397, Danio rerio" xref: Reactome:REACT_84426 "Phosphorylation and Release of IRF3 or IRF7, Taeniopygia guttata" xref: Reactome:REACT_85334 "PKC phosphorylates GRK2, Bos taurus" xref: Reactome:REACT_85934 "Autophosphorylation of FADK1 at Y397, Canis familiaris" xref: Reactome:REACT_86784 "Autophosphorylation of FADK1 at Y397, Taeniopygia guttata" xref: Reactome:REACT_86846 "Activated Src activates ERK, Mus musculus" xref: Reactome:REACT_87050 "Phosphorylation of pFADK1 by SRC, Mus musculus" xref: Reactome:REACT_87514 "Phosphorylation and activation of Ezrin, Sus scrofa" xref: Reactome:REACT_87874 "Phosphorylation of pFADK1 by SRC, Sus scrofa" xref: Reactome:REACT_87926 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Bos taurus" xref: Reactome:REACT_88017 "PKC phosphorylates GRK2, Taeniopygia guttata" xref: Reactome:REACT_88090 "Phosphorylation and release of IRF3/IRF7, Bos taurus" xref: Reactome:REACT_88178 "Phosphorylation and release of IRF3/IRF7, Sus scrofa" xref: Reactome:REACT_88344 "(Frs2)Rap1-GTP binds to and activates B-Raf, Sus scrofa" xref: Reactome:REACT_88685 "Phosphorylation of p130Cas by SRC-FADK1 complex, Xenopus tropicalis" xref: Reactome:REACT_89390 "(Frs2)Rap1-GTP binds to and activates B-Raf, Bos taurus" xref: Reactome:REACT_90060 "Autophosphorylation of FADK1 at Y397, Xenopus tropicalis" xref: Reactome:REACT_90671 "Phosphorylation and activation of Ezrin, Xenopus tropicalis" xref: Reactome:REACT_90879 "Phosphorylation of p130Cas by SRC-FADK1 complex, Gallus gallus" xref: Reactome:REACT_91096 "Activated Src activates ERK, Sus scrofa" xref: Reactome:REACT_93160 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Mus musculus" xref: Reactome:REACT_93476 "(Frs2)Rap1-GTP binds to and activates B-Raf, Canis familiaris" xref: Reactome:REACT_93547 "Activated Src activates ERK, Rattus norvegicus" xref: Reactome:REACT_94091 "Phosphorylation and activation of Ezrin, Bos taurus" xref: Reactome:REACT_95384 "Phosphorylation and Release of IRF3 or IRF7, Mus musculus" xref: Reactome:REACT_96044 "Phosphorylation of p130Cas by SRC-FADK1 complex, Mus musculus" xref: Reactome:REACT_96155 "Phosphorylation and release of IRF3/IRF7, Danio rerio" xref: Reactome:REACT_96307 "Phosphorylation and Release of IRF3 or IRF7, Danio rerio" xref: Reactome:REACT_96320 "Phosphorylation and activation of Ezrin, Rattus norvegicus" xref: Reactome:REACT_96822 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Dictyostelium discoideum" xref: Reactome:REACT_96873 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Caenorhabditis elegans" xref: Reactome:REACT_97267 "PKC phosphorylates GRK2, Gallus gallus" xref: Reactome:REACT_97501 "(Frs2)Rap1-GTP binds to and activates B-Raf, Taeniopygia guttata" xref: Reactome:REACT_97784 "Phosphorylation and activation of Ezrin, Taeniopygia guttata" xref: Reactome:REACT_98334 "Phosphorylation of pFADK1 by SRC, Rattus norvegicus" xref: Reactome:REACT_98994 "(Frs2)Rap1-GTP binds to and activates B-Raf, Gallus gallus" xref: Reactome:REACT_99274 "Phosphorylation of p130Cas by SRC-FADK1 complex, Taeniopygia guttata" is_a: GO:0016740 ! transferase activity relationship: part_of GO:0006464 ! cellular protein modification process [Term] id: GO:0004871 name: signal transducer activity namespace: molecular_function alt_id: GO:0005062 alt_id: GO:0009369 alt_id: GO:0009370 def: "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] comment: Ligands do NOT have the molecular function 'signal transducer activity'. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity" NARROW [] synonym: "quorum sensing response regulator activity" NARROW [] synonym: "quorum sensing signal generator activity" NARROW [] is_a: GO:0003674 ! molecular_function relationship: part_of GO:0007165 ! signal transduction [Term] id: GO:0005198 name: structural molecule activity namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok is_a: GO:0003674 ! molecular_function [Term] id: GO:0005215 name: transporter activity namespace: molecular_function alt_id: GO:0005478 def: "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "small-molecule carrier or transporter" RELATED [] xref: Reactome:REACT_6315 "Virion-associated M2 protein mediated ion infusion, Homo sapiens" is_a: GO:0003674 ! molecular_function relationship: part_of GO:0006810 ! transport [Term] id: GO:0005515 name: protein binding namespace: molecular_function alt_id: GO:0045308 def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "alpha-2 macroglobulin receptor-associated protein activity" RELATED [] synonym: "protein amino acid binding" EXACT [] synonym: "protein degradation tagging activity" RELATED [] synonym: "protein folding chaperone" NARROW [GOC:dph, GOC:mah, GOC:tb] synonym: "protein tagging activity" RELATED [] xref: Reactome:REACT_100287 "Formation of the IGF:IGFBP-4 Complex, Canis familiaris" xref: Reactome:REACT_101129 "Formation of the IGF:IGFBP-3:ALS Complex, Rattus norvegicus" xref: Reactome:REACT_102084 "Formation of the IGF:IGFBP-5:ALS Complex, Mus musculus" xref: Reactome:REACT_102457 "An anchoring protein, SARA, recruits SMAD2/3, Canis familiaris" xref: Reactome:REACT_103972 "Type II receptor recruits type I receptor, Xenopus tropicalis" xref: Reactome:REACT_104029 "Formation of the IGF:IGFBP-6 Complex, Bos taurus" xref: Reactome:REACT_104599 "Type II receptor recruits type I receptor, Sus scrofa" xref: Reactome:REACT_105776 "Formation of the IGF:IGFBP-3:ALS Complex, Danio rerio" xref: Reactome:REACT_105895 "Formation of the IGF:IGFBP-4 Complex, Bos taurus" xref: Reactome:REACT_106168 "Formation of the IGF:IGFBP-2 Complex, Bos taurus" xref: Reactome:REACT_106189 "Formation of the IGF:IGFBP-5:ALS Complex, Gallus gallus" xref: Reactome:REACT_107402 "Formation of the IGF:IGFBP-4 Complex, Mus musculus" xref: Reactome:REACT_108283 "Formation of the IGF:IGFBP-4 Complex, Xenopus tropicalis" xref: Reactome:REACT_109392 "Formation of the IGF:IGFBP-3:ALS Complex, Gallus gallus" xref: Reactome:REACT_110419 "Type II receptor recruits type I receptor, Bos taurus" xref: Reactome:REACT_110570 "Formation of the IGF:IGFBP-3:ALS Complex, Sus scrofa" xref: Reactome:REACT_15321 "Formation of the IGF:IGFBP-1 Complex, Homo sapiens" xref: Reactome:REACT_15325 "Formation of the IGF:IGFBP-4 Complex, Homo sapiens" xref: Reactome:REACT_15355 "Formation of the IGF:IGFBP-5:ALS Complex, Homo sapiens" xref: Reactome:REACT_15417 "Formation of the IGF:IGFBP-3:ALS Complex, Homo sapiens" xref: Reactome:REACT_15419 "Formation of the IGF:IGFBP-2 Complex, Homo sapiens" xref: Reactome:REACT_15506 "Formation of the IGF:IGFBP-6 Complex, Homo sapiens" xref: Reactome:REACT_15541 "Traversal of the cortical actin network and docking at plasma membrane, Homo sapiens" xref: Reactome:REACT_20509 "Exocytosis of Insulin, Mus musculus" xref: Reactome:REACT_20539 "Traversal of the cortical actin network., Mus musculus" xref: Reactome:REACT_28794 "Formation of the IGF:IGFBP-4 Complex, Sus scrofa" xref: Reactome:REACT_30571 "Formation of the IGF:IGFBP-6 Complex, Danio rerio" xref: Reactome:REACT_30672 "Formation of the IGF:IGFBP-2 Complex, Taeniopygia guttata" xref: Reactome:REACT_31305 "Formation of the IGF:IGFBP-3:ALS Complex, Taeniopygia guttata" xref: Reactome:REACT_31537 "Formation of the IGF:IGFBP-6 Complex, Rattus norvegicus" xref: Reactome:REACT_31641 "Type II receptor recruits type I receptor, Danio rerio" xref: Reactome:REACT_31648 "An anchoring protein, SARA, recruits SMAD2/3, Mus musculus" xref: Reactome:REACT_32973 "Formation of the IGF:IGFBP-1 Complex, Canis familiaris" xref: Reactome:REACT_33135 "An anchoring protein, SARA, recruits SMAD2/3, Rattus norvegicus" xref: Reactome:REACT_34719 "Formation of the IGF:IGFBP-1 Complex, Danio rerio" xref: Reactome:REACT_6923 "An anchoring protein, SARA, recruits SMAD2/3, Homo sapiens" xref: Reactome:REACT_6945 "Type II receptor recruits type I receptor, Homo sapiens" xref: Reactome:REACT_78382 "Formation of the IGF:IGFBP-1 Complex, Mus musculus" xref: Reactome:REACT_78466 "Formation of the IGF:IGFBP-6 Complex, Canis familiaris" xref: Reactome:REACT_79634 "Formation of the IGF:IGFBP-5:ALS Complex, Canis familiaris" xref: Reactome:REACT_80470 "Formation of the IGF:IGFBP-1 Complex, Rattus norvegicus" xref: Reactome:REACT_80778 "Type II receptor recruits type I receptor, Mus musculus" xref: Reactome:REACT_83147 "Type II receptor recruits type I receptor, Rattus norvegicus" xref: Reactome:REACT_83165 "Formation of the IGF:IGFBP-5:ALS Complex, Sus scrofa" xref: Reactome:REACT_83532 "Formation of the IGF:IGFBP-2 Complex, Xenopus tropicalis" xref: Reactome:REACT_85250 "Formation of the IGF:IGFBP-2 Complex, Canis familiaris" xref: Reactome:REACT_85858 "Formation of the IGF:IGFBP-2 Complex, Gallus gallus" xref: Reactome:REACT_85975 "An anchoring protein, SARA, recruits SMAD2/3, Danio rerio" xref: Reactome:REACT_87187 "An anchoring protein, SARA, recruits SMAD2/3, Xenopus tropicalis" xref: Reactome:REACT_87374 "Formation of the IGF:IGFBP-6 Complex, Sus scrofa" xref: Reactome:REACT_87652 "Formation of the IGF:IGFBP-5:ALS Complex, Bos taurus" xref: Reactome:REACT_88068 "Formation of the IGF:IGFBP-3:ALS Complex, Canis familiaris" xref: Reactome:REACT_88138 "Formation of the IGF:IGFBP-5:ALS Complex, Danio rerio" xref: Reactome:REACT_88223 "Formation of the IGF:IGFBP-1 Complex, Sus scrofa" xref: Reactome:REACT_89261 "Formation of the IGF:IGFBP-4 Complex, Taeniopygia guttata" xref: Reactome:REACT_90027 "Formation of the IGF:IGFBP-2 Complex, Rattus norvegicus" xref: Reactome:REACT_90105 "Formation of the IGF:IGFBP-1 Complex, Xenopus tropicalis" xref: Reactome:REACT_90666 "An anchoring protein, SARA, recruits SMAD2/3, Sus scrofa" xref: Reactome:REACT_91560 "Type II receptor recruits type I receptor, Canis familiaris" xref: Reactome:REACT_92029 "Formation of the IGF:IGFBP-4 Complex, Rattus norvegicus" xref: Reactome:REACT_93175 "Formation of the IGF:IGFBP-1 Complex, Gallus gallus" xref: Reactome:REACT_93938 "Formation of the IGF:IGFBP-5:ALS Complex, Rattus norvegicus" xref: Reactome:REACT_94522 "Formation of the IGF:IGFBP-5:ALS Complex, Taeniopygia guttata" xref: Reactome:REACT_94808 "Formation of the IGF:IGFBP-6 Complex, Mus musculus" xref: Reactome:REACT_95241 "Formation of the IGF:IGFBP-3:ALS Complex, Mus musculus" xref: Reactome:REACT_95561 "Formation of the IGF:IGFBP-5:ALS Complex, Xenopus tropicalis" xref: Reactome:REACT_95647 "Formation of the IGF:IGFBP-3:ALS Complex, Bos taurus" xref: Reactome:REACT_96236 "Formation of the IGF:IGFBP-2 Complex, Mus musculus" xref: Reactome:REACT_96264 "Formation of the IGF:IGFBP-2 Complex, Danio rerio" xref: Reactome:REACT_98028 "Formation of the IGF:IGFBP-1 Complex, Taeniopygia guttata" xref: Reactome:REACT_98807 "An anchoring protein, SARA, recruits SMAD2/3, Bos taurus" is_a: GO:0003674 ! molecular_function [Term] id: GO:0005575 name: cellular_component namespace: cellular_component alt_id: GO:0008372 def: "The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together." [GOC:go_curators, NIF_Subcellular:sao-1337158144] comment: Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. Note that when this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "cell or subcellular entity" EXACT [] synonym: "cellular component" EXACT [] synonym: "subcellular entity" RELATED [NIF_Subcellular:nlx_subcell_100315] xref: NIF_Subcellular:sao-1337158144 xref: NIF_Subcellular:sao1337158144 [Term] id: GO:0005576 name: extracellular region namespace: cellular_component def: "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] comment: Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "extracellular" EXACT [] xref: Wikipedia:Extracellular is_a: GO:0005575 ! cellular_component [Term] id: GO:0005618 name: cell wall namespace: cellular_component def: "The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins." [GOC:giardia, http://en.wikipedia.org/wiki/Microbial_cyst, ISBN:0198547684, PMID:15134259] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: Wikipedia:Cell_wall is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005575 ! cellular_component [Term] id: GO:0005624 name: obsolete membrane fraction namespace: cellular_component def: "OBSOLETE: That fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes." [GOC:ma] comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component. subset: goslim_aspergillus subset: goslim_candida subset: goslim_yeast subset: gosubset_prok synonym: "membrane fraction" EXACT [] is_obsolete: true consider: GO:0016020 [Term] id: GO:0005634 name: nucleus namespace: cellular_component def: "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "cell nucleus" EXACT [] xref: NIF_Subcellular:sao1702920020 xref: Wikipedia:Cell_nucleus is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005575 ! cellular_component [Term] id: GO:0005694 name: chromosome namespace: cellular_component def: "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "chromatid" RELATED [] synonym: "interphase chromosome" NARROW [] synonym: "prophase chromosome" NARROW [] xref: Wikipedia:Chromosome is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005575 ! cellular_component [Term] id: GO:0005730 name: nucleolus namespace: cellular_component def: "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: NIF_Subcellular:sao1820400233 xref: Wikipedia:Nucleolus is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0005737 name: cytoplasm namespace: cellular_component def: "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: Wikipedia:Cytoplasm is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005575 ! cellular_component [Term] id: GO:0005739 name: mitochondrion namespace: cellular_component def: "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] comment: Some anaerobic or microaerophilic organisms (e.g. Entamoeba histolytica, Giardia intestinalis and several Microsporidia species) do not have mitochondria, and contain mitochondrion-related organelles (MROs) instead, called mitosomes or hydrogenosomes, very likely derived from mitochondria. To annotate gene products located in these mitochondrial relics in species such as Entamoeba histolytica, Giardia intestinalis or others, please use GO:0032047 'mitosome' or GO:0042566 'hydrogenosome'. (See PMID:24316280 for a list of species currently known to contain mitochondrion-related organelles.) subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "mitochondria" EXACT [] xref: NIF_Subcellular:sao1860313010 xref: Wikipedia:Mitochondrion is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005740 name: mitochondrial envelope namespace: cellular_component def: "The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz] subset: goslim_candida subset: goslim_yeast is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005739 ! mitochondrion [Term] id: GO:0005773 name: vacuole namespace: cellular_component def: "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "vacuolar carboxypeptidase Y" RELATED [] xref: Wikipedia:Vacuole is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005777 name: peroxisome namespace: cellular_component alt_id: GO:0019818 def: "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_plant subset: goslim_yeast synonym: "peroxisomal" RELATED [GOC:curators] synonym: "peroxisome vesicle" BROAD [] xref: NIF_Subcellular:sao499555322 xref: Wikipedia:Peroxisome is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005783 name: endoplasmic reticulum namespace: cellular_component def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "ER" EXACT [] xref: NIF_Subcellular:sao1036339110 xref: Wikipedia:Endoplasmic_reticulum is_a: GO:0005575 ! cellular_component relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0005794 name: Golgi apparatus namespace: cellular_component def: "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "Golgi" BROAD [] synonym: "Golgi complex" EXACT [] synonym: "Golgi ribbon" NARROW [] xref: NIF_Subcellular:sao451912436 xref: Wikipedia:Golgi_apparatus is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0005815 name: microtubule organizing center namespace: cellular_component def: "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, http://en.wikipedia.org/wiki/Microtubule_organizing_center, ISBN:0815316194, PMID:17072892, PMID:17245416] subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "microtubule organising centre" EXACT [] synonym: "MTOC" EXACT [] xref: Wikipedia:Microtubule_organizing_center is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005856 ! cytoskeleton [Term] id: GO:0005840 name: ribosome namespace: cellular_component alt_id: GO:0033279 def: "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "free ribosome" NARROW [NIF_Subcellular:sao1139385046] synonym: "membrane bound ribosome" NARROW [NIF_Subcellular:sao1291545653] synonym: "ribosomal RNA" RELATED [] xref: NIF_Subcellular:sao1429207766 xref: Wikipedia:Ribosome is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005856 name: cytoskeleton namespace: cellular_component def: "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: Wikipedia:Cytoskeleton is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005575 ! cellular_component [Term] id: GO:0005886 name: plasma membrane namespace: cellular_component alt_id: GO:0005904 def: "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "bacterial inner membrane" NARROW [] synonym: "cell membrane" EXACT [] synonym: "cellular membrane" EXACT [NIF_Subcellular:sao6433132645] synonym: "cytoplasmic membrane" EXACT [] synonym: "inner endospore membrane" NARROW [] synonym: "juxtamembrane" BROAD [] synonym: "plasma membrane lipid bilayer" NARROW [GOC:mah] synonym: "plasmalemma" EXACT [] xref: NIF_Subcellular:sao1663586795 xref: Wikipedia:Cell_membrane is_a: GO:0016020 ! membrane relationship: part_of GO:0005575 ! cellular_component [Term] id: GO:0005933 name: cellular bud namespace: cellular_component def: "A protuberance from a cell of an organism that reproduces by budding, which will grow larger and become a separate daughter cell after nuclear division, cytokinesis, and cell wall formation (when appropriate). The daughter cell may completely separate from the mother cell, or the mother and daughter cells may remain associated." [GOC:sgd_curators] subset: goslim_candida subset: goslim_pir subset: goslim_yeast is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005575 ! cellular_component [Term] id: GO:0005938 name: cell cortex namespace: cellular_component def: "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] subset: goslim_aspergillus subset: goslim_candida subset: goslim_yeast synonym: "cell periphery" RELATED [] synonym: "peripheral cytoplasm" RELATED [] xref: Wikipedia:Cell_cortex is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005975 name: carbohydrate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "carbohydrate metabolism" EXACT [] xref: Reactome:REACT_102834 "Metabolism of carbohydrates, Mus musculus" xref: Reactome:REACT_103806 "Metabolism of carbohydrates, Mycobacterium tuberculosis" xref: Reactome:REACT_104502 "Metabolism of carbohydrates, Gallus gallus" xref: Reactome:REACT_105321 "Metabolism of carbohydrates, Escherichia coli" xref: Reactome:REACT_106046 "Metabolism of carbohydrates, Drosophila melanogaster" xref: Reactome:REACT_107409 "Metabolism of carbohydrates, Caenorhabditis elegans" xref: Reactome:REACT_115733 "Carbohydrate metabolism, Gallus gallus" xref: Reactome:REACT_28218 "Metabolism of carbohydrates, Xenopus tropicalis" xref: Reactome:REACT_32291 "Metabolism of carbohydrates, Staphylococcus aureus N315" xref: Reactome:REACT_33141 "Metabolism of carbohydrates, Taeniopygia guttata" xref: Reactome:REACT_33953 "Metabolism of carbohydrates, Rattus norvegicus" xref: Reactome:REACT_34800 "Metabolism of carbohydrates, Danio rerio" xref: Reactome:REACT_474 "Metabolism of carbohydrates, Homo sapiens" xref: Reactome:REACT_77669 "Metabolism of carbohydrates, Plasmodium falciparum" xref: Reactome:REACT_81945 "Metabolism of carbohydrates, Schizosaccharomyces pombe" xref: Reactome:REACT_83038 "Metabolism of carbohydrates, Arabidopsis thaliana" xref: Reactome:REACT_83329 "Metabolism of carbohydrates, Saccharomyces cerevisiae" xref: Reactome:REACT_88330 "Metabolism of carbohydrates, Bos taurus" xref: Reactome:REACT_88558 "Metabolism of carbohydrates, Canis familiaris" xref: Reactome:REACT_90099 "Metabolism of carbohydrates, Sus scrofa" xref: Reactome:REACT_96375 "Metabolism of carbohydrates, Dictyostelium discoideum" xref: Reactome:REACT_98394 "Metabolism of carbohydrates, Oryza sativa" xref: Wikipedia:Carbohydrate_metabolism is_a: GO:0008150 ! biological_process [Term] id: GO:0006091 name: generation of precursor metabolites and energy namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl] subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "energy pathways" BROAD [] synonym: "intermediary metabolism" RELATED [GOC:mah] synonym: "metabolic energy generation" RELATED [] is_a: GO:0008150 ! biological_process [Term] id: GO:0006259 name: DNA metabolic process namespace: biological_process alt_id: GO:0055132 def: "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "cellular DNA metabolism" EXACT [] synonym: "DNA metabolism" EXACT [] is_a: GO:0008150 ! biological_process [Term] id: GO:0006412 name: translation namespace: biological_process alt_id: GO:0006416 alt_id: GO:0006453 alt_id: GO:0043037 def: "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "protein anabolism" EXACT [] synonym: "protein biosynthesis" EXACT [] synonym: "protein biosynthetic process" EXACT [GOC:curators] synonym: "protein formation" EXACT [] synonym: "protein synthesis" EXACT [] synonym: "protein translation" EXACT [] xref: Reactome:REACT_100338 "Translation, Sus scrofa" xref: Reactome:REACT_100851 "Translation, Saccharomyces cerevisiae" xref: Reactome:REACT_101045 "Translation, Dictyostelium discoideum" xref: Reactome:REACT_101324 "Translation, Canis familiaris" xref: Reactome:REACT_1014 "Translation, Homo sapiens" xref: Reactome:REACT_103420 "Translation, Plasmodium falciparum" xref: Reactome:REACT_105544 "Translation, Arabidopsis thaliana" xref: Reactome:REACT_29980 "Translation, Bos taurus" xref: Reactome:REACT_33559 "Translation, Rattus norvegicus" xref: Reactome:REACT_77710 "Translation, Drosophila melanogaster" xref: Reactome:REACT_79784 "Translation, Danio rerio" xref: Reactome:REACT_81734 "Translation, Schizosaccharomyces pombe" xref: Reactome:REACT_81833 "Translation, Caenorhabditis elegans" xref: Reactome:REACT_82171 "Translation, Xenopus tropicalis" xref: Reactome:REACT_83429 "Translation, Taeniopygia guttata" xref: Reactome:REACT_83530 "Translation, Gallus gallus" xref: Reactome:REACT_86996 "Translation, Oryza sativa" xref: Reactome:REACT_95535 "Translation, Mus musculus" xref: Reactome:REACT_96394 "Translation, Escherichia coli" xref: Wikipedia:Translation_(genetics) is_a: GO:0008150 ! biological_process relationship: has_part GO:0008150 ! biological_process relationship: part_of GO:0008150 ! biological_process [Term] id: GO:0006457 name: protein folding namespace: biological_process alt_id: GO:0007022 alt_id: GO:0007024 alt_id: GO:0007025 def: "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "alpha-tubulin folding" NARROW [GOC:mah] synonym: "beta-tubulin folding" NARROW [GOC:mah] synonym: "chaperone activity" RELATED [] synonym: "chaperonin ATPase activity" RELATED [] synonym: "chaperonin-mediated tubulin folding" NARROW [GOC:mah] synonym: "co-chaperone activity" RELATED [] synonym: "co-chaperonin activity" RELATED [] synonym: "glycoprotein-specific chaperone activity" RELATED [] synonym: "non-chaperonin molecular chaperone ATPase activity" RELATED [] synonym: "protein complex assembly, multichaperone pathway" RELATED [] xref: Reactome:REACT_100411 "Chaperonin-mediated protein folding, Arabidopsis thaliana" xref: Reactome:REACT_104912 "Chaperonin-mediated protein folding, Caenorhabditis elegans" xref: Reactome:REACT_105663 "Chaperonin-mediated protein folding, Rattus norvegicus" xref: Reactome:REACT_106009 "Chaperonin-mediated protein folding, Canis familiaris" xref: Reactome:REACT_106427 "Chaperonin-mediated protein folding, Mus musculus" xref: Reactome:REACT_106894 "Formation of tubulin folding intermediates by CCT/TriC, Canis familiaris" xref: Reactome:REACT_106927 "Chaperonin-mediated protein folding, Drosophila melanogaster" xref: Reactome:REACT_107029 "Formation of tubulin folding intermediates by CCT/TriC, Drosophila melanogaster" xref: Reactome:REACT_108248 "Chaperonin-mediated protein folding, Gallus gallus" xref: Reactome:REACT_109411 "Formation of tubulin folding intermediates by CCT/TriC, Bos taurus" xref: Reactome:REACT_110417 "Formation of tubulin folding intermediates by CCT/TriC, Rattus norvegicus" xref: Reactome:REACT_16956 "Formation of tubulin folding intermediates by CCT/TriC, Homo sapiens" xref: Reactome:REACT_17001 "Formation of tubulin folding intermediates by CCT/TriC, Mus musculus" xref: Reactome:REACT_17004 "Chaperonin-mediated protein folding, Homo sapiens" xref: Reactome:REACT_17056 "Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding, Bos taurus" xref: Reactome:REACT_23878 "N-glycan trimming in the ER and Calnexin/Calreticulin cycle, Homo sapiens" xref: Reactome:REACT_30906 "Chaperonin-mediated protein folding, Oryza sativa" xref: Reactome:REACT_32155 "Chaperonin-mediated protein folding, Saccharomyces cerevisiae" xref: Reactome:REACT_32255 "Chaperonin-mediated protein folding, Schizosaccharomyces pombe" xref: Reactome:REACT_33395 "Formation of tubulin folding intermediates by CCT/TriC, Mus musculus" xref: Reactome:REACT_77627 "Chaperonin-mediated protein folding, Plasmodium falciparum" xref: Reactome:REACT_77963 "Formation of tubulin folding intermediates by CCT/TriC, Saccharomyces cerevisiae" xref: Reactome:REACT_78530 "Formation of tubulin folding intermediates by CCT/TriC, Gallus gallus" xref: Reactome:REACT_81155 "Formation of tubulin folding intermediates by CCT/TriC, Caenorhabditis elegans" xref: Reactome:REACT_83906 "Chaperonin-mediated protein folding, Dictyostelium discoideum" xref: Reactome:REACT_85492 "Formation of tubulin folding intermediates by CCT/TriC, Sus scrofa" xref: Reactome:REACT_85496 "Formation of tubulin folding intermediates by CCT/TriC, Plasmodium falciparum" xref: Reactome:REACT_86318 "Formation of tubulin folding intermediates by CCT/TriC, Arabidopsis thaliana" xref: Reactome:REACT_91676 "Formation of tubulin folding intermediates by CCT/TriC, Schizosaccharomyces pombe" xref: Reactome:REACT_92785 "Formation of tubulin folding intermediates by CCT/TriC, Dictyostelium discoideum" xref: Reactome:REACT_92961 "Chaperonin-mediated protein folding, Xenopus tropicalis" xref: Reactome:REACT_92981 "Chaperonin-mediated protein folding, Taeniopygia guttata" xref: Reactome:REACT_94123 "Formation of tubulin folding intermediates by CCT/TriC, Taeniopygia guttata" xref: Reactome:REACT_94443 "Formation of tubulin folding intermediates by CCT/TriC, Danio rerio" xref: Reactome:REACT_94772 "Chaperonin-mediated protein folding, Sus scrofa" xref: Reactome:REACT_96773 "Chaperonin-mediated protein folding, Danio rerio" xref: Reactome:REACT_97016 "Chaperonin-mediated protein folding, Bos taurus" xref: Reactome:REACT_97220 "Formation of tubulin folding intermediates by CCT/TriC, Xenopus tropicalis" xref: Reactome:REACT_98132 "Formation of tubulin folding intermediates by CCT/TriC, Oryza sativa" xref: Wikipedia:Protein_folding is_a: GO:0008150 ! biological_process [Term] id: GO:0006464 name: cellular protein modification process namespace: biological_process def: "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "process resulting in protein modification" RELATED [] synonym: "protein modification process" BROAD [GOC:bf, GOC:jl] synonym: "protein tagging activity" RELATED [] is_a: GO:0008150 ! biological_process [Term] id: GO:0006629 name: lipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "lipid metabolism" EXACT [] xref: Reactome:REACT_104930 "Lipid digestion, mobilization, and transport, Drosophila melanogaster" xref: Reactome:REACT_107479 "Lipid digestion, mobilization, and transport, Xenopus tropicalis" xref: Reactome:REACT_108775 "Lipid digestion, mobilization, and transport, Canis familiaris" xref: Reactome:REACT_114669 "Lipid digestion, mobilization, and transport, Staphylococcus aureus N315" xref: Reactome:REACT_115652 "Lipid metabolism, Gallus gallus" xref: Reactome:REACT_28745 "Lipid digestion, mobilization, and transport, Saccharomyces cerevisiae" xref: Reactome:REACT_31395 "Lipid digestion, mobilization, and transport, Sus scrofa" xref: Reactome:REACT_32539 "Lipid digestion, mobilization, and transport, Bos taurus" xref: Reactome:REACT_33836 "Lipid digestion, mobilization, and transport, Rattus norvegicus" xref: Reactome:REACT_602 "Lipid digestion, mobilization, and transport, Homo sapiens" xref: Reactome:REACT_77176 "Lipid digestion, mobilization, and transport, Danio rerio" xref: Reactome:REACT_77191 "Lipid digestion, mobilization, and transport, Arabidopsis thaliana" xref: Reactome:REACT_79244 "Lipid digestion, mobilization, and transport, Plasmodium falciparum" xref: Reactome:REACT_81778 "Lipid digestion, mobilization, and transport, Oryza sativa" xref: Reactome:REACT_82512 "Lipid digestion, mobilization, and transport, Taeniopygia guttata" xref: Reactome:REACT_82723 "Lipid digestion, mobilization, and transport, Escherichia coli" xref: Reactome:REACT_87884 "Lipid digestion, mobilization, and transport, Caenorhabditis elegans" xref: Reactome:REACT_90757 "Lipid digestion, mobilization, and transport, Mus musculus" xref: Reactome:REACT_94607 "Lipid digestion, mobilization, and transport, Mycobacterium tuberculosis" xref: Reactome:REACT_97906 "Lipid digestion, mobilization, and transport, Gallus gallus" xref: Reactome:REACT_98129 "Lipid digestion, mobilization, and transport, Schizosaccharomyces pombe" xref: Reactome:REACT_99706 "Lipid digestion, mobilization, and transport, Dictyostelium discoideum" xref: Wikipedia:Lipid_metabolism is_a: GO:0008150 ! biological_process [Term] id: GO:0006766 name: vitamin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems." [GOC:ai] subset: goslim_aspergillus subset: goslim_candida subset: goslim_pir subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "vitamin metabolism" EXACT [] xref: Reactome:REACT_101808 "Metabolism of vitamins and cofactors, Bos taurus" xref: Reactome:REACT_101968 "Metabolism of vitamins and cofactors, Saccharomyces cerevisiae" xref: Reactome:REACT_102472 "Vitamins, Xenopus tropicalis" xref: Reactome:REACT_103646 "Metabolism of vitamins and cofactors, Staphylococcus aureus N315" xref: Reactome:REACT_104403 "Vitamins, Bos taurus" xref: Reactome:REACT_105907 "Metabolism of vitamins and cofactors, Danio rerio" xref: Reactome:REACT_106152 "Metabolism of vitamins and cofactors, Xenopus tropicalis" xref: Reactome:REACT_108558 "Metabolism of vitamins and cofactors, Rattus norvegicus" xref: Reactome:REACT_110948 "Metabolism of vitamins and cofactors, Sus scrofa" xref: Reactome:REACT_11193 "Metabolism of vitamins and cofactors, Homo sapiens" xref: Reactome:REACT_13450 "Vitamins, Homo sapiens" xref: Reactome:REACT_30091 "Metabolism of vitamins and cofactors, Oryza sativa" xref: Reactome:REACT_31562 "Vitamins, Sus scrofa" xref: Reactome:REACT_33241 "Vitamins, Oryza sativa" xref: Reactome:REACT_33738 "Metabolism of vitamins and cofactors, Mycobacterium tuberculosis" xref: Reactome:REACT_34161 "Metabolism of vitamins and cofactors, Mus musculus" xref: Reactome:REACT_34372 "Vitamins, Taeniopygia guttata" xref: Reactome:REACT_36524 "Vitamins, Gallus gallus" xref: Reactome:REACT_78899 "Metabolism of vitamins and cofactors, Caenorhabditis elegans" xref: Reactome:REACT_79004 "Vitamins, Danio rerio" xref: Reactome:REACT_80415 "Vitamins, Rattus norvegicus" xref: Reactome:REACT_81509 "Metabolism of vitamins and cofactors, Gallus gallus" xref: Reactome:REACT_82129 "Metabolism of vitamins and cofactors, Taeniopygia guttata" xref: Reactome:REACT_82903 "Vitamins, Canis familiaris" xref: Reactome:REACT_83508 "Metabolism of vitamins and cofactors, Arabidopsis thaliana" xref: Reactome:REACT_84128 "Vitamins, Drosophila melanogaster" xref: Reactome:REACT_87513 "Metabolism of vitamins and cofactors, Schizosaccharomyces pombe" xref: Reactome:REACT_88847 "Vitamins, Mus musculus" xref: Reactome:REACT_88850 "Metabolism of vitamins and cofactors, Dictyostelium discoideum" xref: Reactome:REACT_90099 "Vitamins, Arabidopsis thaliana" xref: Reactome:REACT_96278 "Metabolism of vitamins and cofactors, Plasmodium falciparum" xref: Reactome:REACT_96904 "Metabolism of vitamins and cofactors, Drosophila melanogaster" xref: Reactome:REACT_97734 "Metabolism of vitamins and cofactors, Escherichia coli" xref: Reactome:REACT_97893 "Metabolism of vitamins and cofactors, Canis familiaris" is_a: GO:0008150 ! biological_process [Term] id: GO:0006810 name: transport namespace: biological_process alt_id: GO:0015457 alt_id: GO:0015460 def: "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "auxiliary transport protein activity" RELATED [GOC:mah] synonym: "small molecule transport" NARROW [] synonym: "solute:solute exchange" NARROW [] synonym: "transport accessory protein activity" RELATED [GOC:mah] is_a: GO:0008150 ! biological_process [Term] id: GO:0006950 name: response to stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant subset: gosubset_prok synonym: "response to abiotic stress" RELATED [] synonym: "response to biotic stress" RELATED [] is_a: GO:0008150 ! biological_process [Term] id: GO:0006996 name: organelle organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] subset: goslim_aspergillus subset: goslim_candida subset: goslim_pir subset: gosubset_prok synonym: "organelle organisation" EXACT [GOC:curators] synonym: "organelle organization and biogenesis" RELATED [GOC:dph, GOC:jl, GOC:mah] is_a: GO:0008150 ! biological_process [Term] id: GO:0006997 name: nucleus organization namespace: biological_process alt_id: GO:0048287 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus." [GOC:dph, GOC:ems, GOC:jl, GOC:mah] subset: goslim_aspergillus subset: goslim_candida subset: goslim_pir subset: goslim_yeast synonym: "nuclear morphology" RELATED [] synonym: "nuclear organisation" EXACT [GOC:curators] synonym: "nuclear organization" EXACT [GOC:curators] synonym: "nuclear organization and biogenesis" RELATED [GOC:mah] synonym: "nucleus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0007010 name: cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "cytoskeletal organization and biogenesis" RELATED [GOC:mah] synonym: "cytoskeletal regulator activity" RELATED [] synonym: "cytoskeleton organisation" EXACT [GOC:curators] synonym: "cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0007049 name: cell cycle namespace: biological_process def: "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] subset: gocheck_do_not_manually_annotate subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "cell-division cycle" EXACT [] xref: Wikipedia:Cell_cycle is_a: GO:0008150 ! biological_process [Term] id: GO:0007114 name: cell budding namespace: biological_process def: "A form of asexual reproduction, occurring in certain bacteria and fungi (e.g. yeasts) and some primitive animals in which an individual arises from a daughter cell formed by pinching off a part of the parent cell. The budlike outgrowths so formed may sometimes remain attached to the parent cell." [ISBN:0198506732] subset: goslim_candida subset: goslim_yeast subset: gosubset_prok synonym: "budding" BROAD [] is_a: GO:0008150 ! biological_process [Term] id: GO:0007124 name: pseudohyphal growth namespace: biological_process def: "A pattern of cell growth that occurs in conditions of nitrogen limitation and abundant fermentable carbon source. Cells become elongated, switch to a unipolar budding pattern, remain physically attached to each other, and invade the growth substrate." [GOC:krc, PMID:11104818] subset: goslim_candida subset: goslim_yeast is_a: GO:0070783 ! growth of unicellular organism as a thread of attached cells [Term] id: GO:0007155 name: cell adhesion namespace: biological_process def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: gosubset_prok synonym: "cell adhesion molecule activity" RELATED [] xref: Wikipedia:Cell_adhesion is_a: GO:0008150 ! biological_process [Term] id: GO:0007165 name: signal transduction namespace: biological_process alt_id: GO:0023033 def: "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] comment: Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant subset: gosubset_prok synonym: "signaling cascade" NARROW [] synonym: "signaling pathway" RELATED [] synonym: "signalling cascade" NARROW [] synonym: "signalling pathway" RELATED [GOC:mah] xref: Reactome:REACT_100624 "EGFR interacts with phospholipase C-gamma, Gallus gallus" xref: Reactome:REACT_102354 "EGFR interacts with phospholipase C-gamma, Canis familiaris" xref: Reactome:REACT_112130 "EGFR interacts with phospholipase C-gamma, Oryza sativa" xref: Reactome:REACT_112549 "EGFR interacts with phospholipase C-gamma, Arabidopsis thaliana" xref: Reactome:REACT_113151 "EGFR interacts with phospholipase C-gamma, Mycobacterium tuberculosis" xref: Reactome:REACT_113601 "EGFR interacts with phospholipase C-gamma, Drosophila melanogaster" xref: Reactome:REACT_113964 "EGFR interacts with phospholipase C-gamma, Bos taurus" xref: Reactome:REACT_114657 "EGFR interacts with phospholipase C-gamma, Dictyostelium discoideum" xref: Reactome:REACT_114690 "EGFR interacts with phospholipase C-gamma, Saccharomyces cerevisiae" xref: Reactome:REACT_114820 "EGFR interacts with phospholipase C-gamma, Sus scrofa" xref: Reactome:REACT_114910 "EGFR interacts with phospholipase C-gamma, Caenorhabditis elegans" xref: Reactome:REACT_115037 "EGFR interacts with phospholipase C-gamma, Plasmodium falciparum" xref: Reactome:REACT_115147 "EGFR interacts with phospholipase C-gamma, Schizosaccharomyces pombe" xref: Reactome:REACT_12478 "EGFR interacts with phospholipase C-gamma, Homo sapiens" xref: Reactome:REACT_31232 "EGFR interacts with phospholipase C-gamma, Rattus norvegicus" xref: Reactome:REACT_78535 "EGFR interacts with phospholipase C-gamma, Xenopus tropicalis" xref: Reactome:REACT_89740 "EGFR interacts with phospholipase C-gamma, Taeniopygia guttata" xref: Reactome:REACT_93680 "EGFR interacts with phospholipase C-gamma, Danio rerio" xref: Reactome:REACT_98872 "EGFR interacts with phospholipase C-gamma, Mus musculus" xref: Wikipedia:Signal_transduction is_a: GO:0050789 ! regulation of biological process relationship: part_of GO:0008150 ! biological_process [Term] id: GO:0008150 name: biological_process namespace: biological_process alt_id: GO:0000004 alt_id: GO:0007582 def: "Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end." [GOC:go_curators, GOC:isa_complete] comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. Note that when this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "biological process" EXACT [] synonym: "physiological process" EXACT [] xref: Wikipedia:Biological_process [Term] id: GO:0008233 name: peptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "hydrolase, acting on peptide bonds" EXACT [] synonym: "peptide hydrolase activity" EXACT [] synonym: "protease activity" EXACT [] synonym: "proteinase activity" EXACT [] xref: EC:3.4 xref: Reactome:REACT_106748 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6, Rattus norvegicus" xref: Reactome:REACT_110349 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6, Mus musculus" xref: Reactome:REACT_13710 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6, Homo sapiens" xref: Reactome:REACT_19284 "Proteolytic processing of Slit, Homo sapiens" xref: Reactome:REACT_93020 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6, Bos taurus" xref: Reactome:REACT_99630 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6, Gallus gallus" is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0008289 name: lipid binding namespace: molecular_function def: "Interacting selectively and non-covalently with a lipid." [GOC:ai] subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok is_a: GO:0003674 ! molecular_function [Term] id: GO:0009405 name: pathogenesis namespace: biological_process def: "The set of specific processes that generate the ability of an organism to cause disease in another." [GOC:go_curators] comment: Note that this term should not be used to annotate gene products that are involved in the host response to pathogenesis. It should only be used to annotate those gene products involved in the generation of pathogenesis by the pathogen itself. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: gosubset_prok synonym: "channel-forming toxin activity" RELATED [] synonym: "cytotoxin activity" RELATED [] synonym: "endotoxin activity" RELATED [] synonym: "enterotoxin activity" RELATED [] synonym: "exotoxin activity" RELATED [] synonym: "lipoprotein toxin" RELATED [] synonym: "neurotoxin activity" RELATED [] synonym: "pore-forming toxin activity" RELATED [] synonym: "toxin activity" RELATED [] synonym: "virulence" RELATED [] is_a: GO:0008150 ! biological_process [Term] id: GO:0012505 name: endomembrane system namespace: cellular_component def: "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh] subset: goslim_aspergillus subset: goslim_candida subset: goslim_yeast xref: Wikipedia:Endomembrane_system is_a: GO:0005575 ! cellular_component relationship: has_part GO:0005773 ! vacuole relationship: has_part GO:0005886 ! plasma membrane relationship: part_of GO:0005575 ! cellular_component [Term] id: GO:0016020 name: membrane namespace: cellular_component def: "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: Wikipedia:Biological_membrane is_a: GO:0005575 ! cellular_component [Term] id: GO:0016023 name: cytoplasmic membrane-bounded vesicle namespace: cellular_component def: "A membrane-bounded vesicle found in the cytoplasm of the cell." [GOC:ai, GOC:mah] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_yeast subset: gosubset_prok synonym: "cytoplasmic membrane bounded vesicle" EXACT [] synonym: "cytoplasmic membrane-enclosed vesicle" EXACT [] is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0016070 name: RNA metabolic process namespace: biological_process def: "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_metagenomics subset: goslim_pir subset: gosubset_prok synonym: "RNA metabolism" EXACT [] xref: Reactome:REACT_107259 "Metabolism of RNA, Sus scrofa" xref: Reactome:REACT_107652 "Metabolism of RNA, Schizosaccharomyces pombe" xref: Reactome:REACT_110289 "Metabolism of RNA, Danio rerio" xref: Reactome:REACT_21257 "Metabolism of RNA, Homo sapiens" xref: Reactome:REACT_30579 "Metabolism of RNA, Xenopus tropicalis" xref: Reactome:REACT_31367 "Metabolism of RNA, Dictyostelium discoideum" xref: Reactome:REACT_33720 "Metabolism of RNA, Plasmodium falciparum" xref: Reactome:REACT_80071 "Metabolism of RNA, Caenorhabditis elegans" xref: Reactome:REACT_83630 "Metabolism of RNA, Taeniopygia guttata" xref: Reactome:REACT_84169 "Metabolism of RNA, Canis familiaris" xref: Reactome:REACT_85788 "Metabolism of RNA, Oryza sativa" xref: Reactome:REACT_88316 "Metabolism of RNA, Mus musculus" xref: Reactome:REACT_89992 "Metabolism of RNA, Saccharomyces cerevisiae" xref: Reactome:REACT_91556 "Metabolism of RNA, Bos taurus" xref: Reactome:REACT_92152 "Metabolism of RNA, Drosophila melanogaster" xref: Reactome:REACT_94876 "Metabolism of RNA, Arabidopsis thaliana" xref: Reactome:REACT_99403 "Metabolism of RNA, Rattus norvegicus" xref: Reactome:REACT_99885 "Metabolism of RNA, Gallus gallus" is_a: GO:0008150 ! biological_process [Term] id: GO:0016192 name: vesicle-mediated transport namespace: biological_process alt_id: GO:0006899 def: "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: gosubset_prok synonym: "nonselective vesicle transport" NARROW [] synonym: "protein sorting along secretory pathway" RELATED [] synonym: "vesicle trafficking" RELATED [] synonym: "vesicle transport" EXACT [] synonym: "vesicular transport" EXACT [GOC:mah] is_a: GO:0006810 ! transport [Term] id: GO:0016491 name: oxidoreductase activity namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] comment: Note that enzymes of class EC:1.97.-.- should also be annotated to this term. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "oxidoreductase activity, acting on other substrates" NARROW [] synonym: "redox activity" EXACT [] xref: EC:1 xref: Reactome:REACT_102858 "Diiodinated tyrosine can be deiodinated, Mus musculus" xref: Reactome:REACT_102973 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Canis familiaris" xref: Reactome:REACT_103874 "Monoiodinated tyrosine can be deiodinated, Canis familiaris" xref: Reactome:REACT_104604 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Danio rerio" xref: Reactome:REACT_105062 "Monoiodinated tyrosine can be deiodinated, Danio rerio" xref: Reactome:REACT_105121 "Monoiodinated tyrosine can be deiodinated, Caenorhabditis elegans" xref: Reactome:REACT_106088 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Rattus norvegicus" xref: Reactome:REACT_106276 "Monoiodinated tyrosine can be deiodinated, Rattus norvegicus" xref: Reactome:REACT_107002 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Sus scrofa" xref: Reactome:REACT_107467 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Rattus norvegicus" xref: Reactome:REACT_108745 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Taeniopygia guttata" xref: Reactome:REACT_109500 "Monoiodinated tyrosine can be deiodinated, Bos taurus" xref: Reactome:REACT_110582 "Diiodinated tyrosine can be deiodinated, Rattus norvegicus" xref: Reactome:REACT_115316 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Drosophila melanogaster" xref: Reactome:REACT_15389 "Monoiodinated tyrosine can be deiodinated, Homo sapiens" xref: Reactome:REACT_15410 "Diiodinated tyrosine can be deiodinated, Homo sapiens" xref: Reactome:REACT_17006 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Homo sapiens" xref: Reactome:REACT_17042 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Homo sapiens" xref: Reactome:REACT_29212 "Diiodinated tyrosine can be deiodinated, Canis familiaris" xref: Reactome:REACT_30160 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Mus musculus" xref: Reactome:REACT_31762 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Gallus gallus" xref: Reactome:REACT_32960 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Bos taurus" xref: Reactome:REACT_34705 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Mus musculus" xref: Reactome:REACT_44470 "Monoiodinated tyrosine can be deiodinated, Mus musculus" xref: Reactome:REACT_78923 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Taeniopygia guttata" xref: Reactome:REACT_84842 "Diiodinated tyrosine can be deiodinated, Gallus gallus" xref: Reactome:REACT_86178 "Monoiodinated tyrosine can be deiodinated, Xenopus tropicalis" xref: Reactome:REACT_88304 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Bos taurus" xref: Reactome:REACT_89057 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Gallus gallus" xref: Reactome:REACT_90394 "Diiodinated tyrosine can be deiodinated, Xenopus tropicalis" xref: Reactome:REACT_91638 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Arabidopsis thaliana" xref: Reactome:REACT_91952 "Monoiodinated tyrosine can be deiodinated, Gallus gallus" xref: Reactome:REACT_92075 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Xenopus tropicalis" xref: Reactome:REACT_92434 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Canis familiaris" xref: Reactome:REACT_93539 "Diiodinated tyrosine can be deiodinated, Drosophila melanogaster" xref: Reactome:REACT_93974 "Diiodinated tyrosine can be deiodinated, Taeniopygia guttata" xref: Reactome:REACT_95169 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Danio rerio" xref: Reactome:REACT_95558 "Monoiodinated tyrosine can be deiodinated, Sus scrofa" xref: Reactome:REACT_95573 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Caenorhabditis elegans" xref: Reactome:REACT_97234 "Diiodinated tyrosine can be deiodinated, Caenorhabditis elegans" xref: Reactome:REACT_97568 "Diiodinated tyrosine can be deiodinated, Sus scrofa" xref: Reactome:REACT_97851 "Diiodinated tyrosine can be deiodinated, Bos taurus" xref: Reactome:REACT_98022 "Monoiodinated tyrosine can be deiodinated, Drosophila melanogaster" xref: Reactome:REACT_99085 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Oryza sativa" xref: Reactome:REACT_99794 "Diiodinated tyrosine can be deiodinated, Danio rerio" xref: Reactome:REACT_99989 "Monoiodinated tyrosine can be deiodinated, Taeniopygia guttata" is_a: GO:0003674 ! molecular_function relationship: part_of GO:0008150 ! biological_process [Term] id: GO:0016740 name: transferase activity namespace: molecular_function def: "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: EC:2 xref: Reactome:REACT_25050 "Molybdenum ion transfer onto molybdopterin, Homo sapiens" is_a: GO:0003674 ! molecular_function relationship: part_of GO:0008150 ! biological_process [Term] id: GO:0016779 name: nucleotidyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_yeast subset: gosubset_prok xref: EC:2.7.7 is_a: GO:0016740 ! transferase activity [Term] id: GO:0016787 name: hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: EC:3 xref: Reactome:REACT_110436 "Hydrolysis of phosphatidylcholine, Bos taurus" xref: Reactome:REACT_111159 "Partial proteolysis of antigen in phagolysosomes, Homo sapiens" xref: Reactome:REACT_15331 "Hydrolysis of phosphatidylcholine, Homo sapiens" xref: Reactome:REACT_83734 "Hydrolysis of phosphatidylcholine, Danio rerio" xref: Reactome:REACT_84047 "Hydrolysis of phosphatidylcholine, Xenopus tropicalis" xref: Reactome:REACT_87959 "Hydrolysis of phosphatidylcholine, Gallus gallus" xref: Reactome:REACT_88159 "Hydrolysis of phosphatidylcholine, Canis familiaris" xref: Reactome:REACT_90118 "Hydrolysis of phosphatidylcholine, Mus musculus" xref: Reactome:REACT_91045 "Hydrolysis of phosphatidylcholine, Taeniopygia guttata" xref: Reactome:REACT_98572 "Hydrolysis of phosphatidylcholine, Rattus norvegicus" is_a: GO:0003674 ! molecular_function relationship: part_of GO:0008150 ! biological_process [Term] id: GO:0016791 name: phosphatase activity namespace: molecular_function alt_id: GO:0003869 alt_id: GO:0016302 def: "Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, EC:3.1.3.41, GOC:curators, GOC:pg] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_yeast subset: gosubset_prok synonym: "4-nitrophenylphosphatase activity" NARROW [] synonym: "4-nitrophenylphosphate phosphohydrolase activity" NARROW [EC:3.1.3.41] synonym: "ecto-p-nitrophenyl phosphatase activity" NARROW [EC:3.1.3.41] synonym: "K-pNPPase activity" NARROW [EC:3.1.3.41] synonym: "nitrophenyl phosphatase activity" NARROW [EC:3.1.3.41] synonym: "NPPase activity" NARROW [EC:3.1.3.41] synonym: "p-nitrophenylphosphatase activity" NARROW [EC:3.1.3.41] synonym: "p-nitrophenylphosphate phosphohydrolase activity" NARROW [EC:3.1.3.41] synonym: "para-nitrophenyl phosphatase activity" NARROW [EC:3.1.3.41] synonym: "phosphatase" RELATED [] synonym: "phosphoric monoester hydrolase activity" EXACT [] synonym: "PNPPase activity" NARROW [EC:3.1.3.41] xref: EC:3.1.3 xref: EC:3.1.3.41 xref: MetaCyc:4-NITROPHENYLPHOSPHATASE-RXN xref: RHEA:21667 is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016829 name: lyase activity namespace: molecular_function def: "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684] comment: Note that enzymes of class EC:4.99.-.- should also be annotated to this term. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "other lyase activity" NARROW [] xref: EC:4 is_a: GO:0003674 ! molecular_function relationship: part_of GO:0008150 ! biological_process [Term] id: GO:0016853 name: isomerase activity namespace: molecular_function def: "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] comment: Note that enzymes of class EC:5.99.-.- should also be annotated to this term. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "other isomerase activity" NARROW [] xref: EC:5 is_a: GO:0003674 ! molecular_function relationship: part_of GO:0008150 ! biological_process [Term] id: GO:0016874 name: ligase activity namespace: molecular_function def: "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "synthetase activity" EXACT [GOC:jh2] xref: EC:6 xref: Reactome:REACT_115603 "Ligation of DNA at sites of patch replacement, Gallus gallus" xref: Reactome:REACT_116018 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Gallus gallus" is_a: GO:0003674 ! molecular_function relationship: part_of GO:0008150 ! biological_process [Term] id: GO:0019725 name: cellular homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state at the level of the cell." [GOC:isa_complete, GOC:jl, ISBN:0395825172] subset: goslim_aspergillus subset: goslim_candida subset: goslim_plant subset: gosubset_prok is_a: GO:0008150 ! biological_process relationship: occurs_in GO:0005575 ! cellular_component [Term] id: GO:0030163 name: protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah] comment: This term refers to the breakdown of mature proteins. For cleavage events involved in generating a mature protein from a precursor, consider instead the term 'protein maturation ; GO:0051604' and its children. subset: goslim_aspergillus subset: goslim_candida subset: goslim_pombe subset: gosubset_prok synonym: "pheromone catabolic process" RELATED [] synonym: "pheromone catabolism" RELATED [] synonym: "protein breakdown" EXACT [] synonym: "protein catabolism" EXACT [] synonym: "protein degradation" EXACT [] xref: Wikipedia:Protein_catabolism is_a: GO:0008150 ! biological_process [Term] id: GO:0030234 name: enzyme regulator activity namespace: molecular_function def: "Binds to and modulates the activity of an enzyme." [GOC:mah] comment: GO:0030234 is reserved for cases when the regulator directly interacts with the enzyme. When regulation of enzyme activity is achieved without enzyme binding, or when the mechanism of regulation is unknown, instead annotate to 'regulation of catalytic activity ; GO:0050790'. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "catalytic regulator activity" EXACT [GOC:dph] synonym: "enzyme modulator" EXACT [] is_a: GO:0003674 ! molecular_function relationship: has_part GO:0005515 ! protein binding relationship: part_of GO:0050789 ! regulation of biological process [Term] id: GO:0030427 name: site of polarized growth namespace: cellular_component alt_id: GO:0000134 alt_id: GO:0030483 def: "Any part of a cell where non-isotropic growth takes place." [GOC:mah] subset: goslim_aspergillus subset: goslim_candida subset: goslim_pir subset: goslim_yeast is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005575 ! cellular_component [Term] id: GO:0030447 name: filamentous growth namespace: biological_process def: "The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:mcc, PMID:11729141] subset: goslim_aspergillus subset: goslim_candida is_a: GO:0008150 ! biological_process [Term] id: GO:0030448 name: hyphal growth namespace: biological_process def: "Growth of fungi as threadlike, tubular structures that may contain multiple nuclei and may or may not be divided internally by septa, or cross-walls." [GOC:mcc, ISBN:0471522295] subset: goslim_candida is_a: GO:0030447 ! filamentous growth [Term] id: GO:0030533 name: triplet codon-amino acid adaptor activity namespace: molecular_function def: "The codon binding activity of a tRNA that positions an activated amino acid, mediating its insertion at the correct point in the sequence of a nascent polypeptide chain during protein synthesis." [GOC:hjd, GOC:mtg_MIT_16mar07, ISBN:0198506732] comment: Note that this term can be used in place of the obsolete term 'transfer RNA ; GO:0005563'. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "transfer RNA" RELATED [] synonym: "tRNA" RELATED [] is_a: GO:0003723 ! RNA binding relationship: part_of GO:0006412 ! translation [Term] id: GO:0032196 name: transposition namespace: biological_process def: "Any process involved in mediating the movement of discrete segments of DNA between nonhomologous sites." [GOC:jp, ISBN:1555812090] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast subset: gosubset_prok xref: Wikipedia:Transposon is_a: GO:0008150 ! biological_process [Term] id: GO:0042221 name: response to chemical namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_aspergillus subset: goslim_candida subset: goslim_yeast subset: gosubset_prok synonym: "response to chemical stimulus" EXACT [GOC:dos] synonym: "response to chemical substance" EXACT [] is_a: GO:0008150 ! biological_process [Term] id: GO:0042254 name: ribosome biogenesis namespace: biological_process alt_id: GO:0007046 def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: gosubset_prok synonym: "ribosomal chaperone activity" RELATED [] synonym: "ribosome biogenesis and assembly" EXACT [] xref: Wikipedia:Ribosome_biogenesis is_a: GO:0008150 ! biological_process [Term] id: GO:0042493 name: response to drug namespace: biological_process alt_id: GO:0017035 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease." [GOC:jl] subset: goslim_candida subset: gosubset_prok synonym: "drug resistance" RELATED [] synonym: "drug susceptibility/resistance" RELATED [] is_a: GO:0042221 ! response to chemical [Term] id: GO:0042710 name: biofilm formation namespace: biological_process def: "A process in which planktonically growing microorganisms grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:di, PMID:11932229] subset: gocheck_do_not_annotate subset: gocheck_do_not_manually_annotate subset: goslim_candida subset: goslim_pir subset: gosubset_prok is_a: GO:0008150 ! biological_process [Term] id: GO:0044419 name: interspecies interaction between organisms namespace: biological_process def: "Any process in which an organism has an effect on an organism of a different species." [GOC:cc] subset: goslim_candida subset: goslim_pir subset: gosubset_prok synonym: "interaction with another species" EXACT [] synonym: "interspecies interaction" EXACT [] synonym: "interspecies interaction with other organisms" EXACT [] is_a: GO:0008150 ! biological_process [Term] id: GO:0045182 name: translation regulator activity namespace: molecular_function def: "Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome." [GOC:ai] subset: goslim_aspergillus subset: goslim_candida subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "translation factor activity" EXACT [] is_a: GO:0003674 ! molecular_function relationship: part_of GO:0050789 ! regulation of biological process [Term] id: GO:0045333 name: cellular respiration namespace: biological_process def: "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)." [GOC:das, ISBN:0140513590, ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "oxidative metabolic process" EXACT [] synonym: "oxidative metabolism" EXACT [] synonym: "respiration" BROAD [] xref: Wikipedia:Cellular_respiration is_a: GO:0006091 ! generation of precursor metabolites and energy [Term] id: GO:0048468 name: cell development namespace: biological_process def: "The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:go_curators] subset: goslim_candida subset: gosubset_prok synonym: "terminal differentiation" RELATED [GOC:dph, GOC:tb] is_a: GO:0008150 ! biological_process relationship: part_of GO:0008150 ! biological_process [Term] id: GO:0050789 name: regulation of biological process namespace: biological_process alt_id: GO:0050791 def: "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators] subset: goslim_aspergillus subset: goslim_candida subset: gosubset_prok synonym: "regulation of physiological process" EXACT [] is_a: GO:0008150 ! biological_process relationship: regulates GO:0008150 ! biological_process [Term] id: GO:0070732 name: spindle envelope namespace: cellular_component def: "An organelle envelope that surrounds the chromosomes and the central part of the spindle apparatus during mitosis and meiosis; observed in many invertebrates. The spindle envelope consists of membrane layers, called parafusorial membranes, derived from endoplasmic reticulum membrane; in male meiosis it forms during prometaphase and persists until early in the ensuing interphase." [GOC:mah, GOC:sart, PMID:19417004, PMID:6428889] subset: goslim_candida is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005575 ! cellular_component created_by: midori creation_date: 2009-06-18T12:00:59Z [Term] id: GO:0070783 name: growth of unicellular organism as a thread of attached cells namespace: biological_process def: "A filamentous growth process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium such as an agar plate, exhibited by unicellular fungi under certain growth conditions." [GOC:mah, GOC:mcc] subset: goslim_candida is_a: GO:0030447 ! filamentous growth created_by: midori creation_date: 2009-07-07T02:21:14Z [Term] id: GO:0071555 name: cell wall organization namespace: biological_process alt_id: GO:0007047 alt_id: GO:0044234 def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:mah] subset: goslim_candida subset: goslim_pir subset: gosubset_prok synonym: "cell wall organisation" EXACT [GOC:curators] synonym: "cell wall organisation in other organism" EXACT [GOC:mah] synonym: "cell wall organization and biogenesis" RELATED [GOC:mah] synonym: "cell wall organization at cellular level" EXACT [GOC:mah] synonym: "cell wall organization in other organism" EXACT [] synonym: "cellular cell wall organisation" EXACT [GOC:curators] synonym: "cellular cell wall organization" EXACT [] is_a: GO:0008150 ! biological_process created_by: midori creation_date: 2010-01-13T03:33:07Z [Typedef] id: ends_during name: ends_during namespace: external xref: RO:0002093 [Typedef] id: happens_during name: happens_during namespace: external xref: RO:0002092 is_transitive: true is_a: ends_during ! ends_during [Typedef] id: has_part name: has_part namespace: external xref: BFO:0000051 is_transitive: true [Typedef] id: negatively_regulates name: negatively regulates namespace: external xref: RO:0002212 is_a: regulates ! regulates transitive_over: part_of ! part of [Typedef] id: never_in_taxon name: never_in_taxon namespace: external xref: RO:0002161 expand_assertion_to: "Class: ?X DisjointWith: RO_0002162 some ?Y" [] is_metadata_tag: true is_class_level: true [Typedef] id: occurs_in name: occurs in namespace: external xref: BFO:0000066 holds_over_chain: part_of occurs_in transitive_over: part_of ! part of [Typedef] id: part_of name: part of namespace: external xref: BFO:0000050 is_transitive: true inverse_of: has_part ! has_part [Typedef] id: positively_regulates name: positively regulates namespace: external xref: RO:0002213 is_a: regulates ! regulates transitive_over: part_of ! part of [Typedef] id: regulates name: regulates namespace: external xref: RO:0002211 transitive_over: part_of ! part of [Typedef] id: starts_during name: starts_during namespace: external xref: RO:0002091