UniqueID (Johnson lab) orf6 # orf19 # Name (Candida Annotation Working Group) Annotation (Candida Annotation Working Group) Gene class(es) nrg1/WT #1 nrg1/WT #2 nrg1/WT #3 nrg1/WT #4 nrg1/WT #5 nrg1/WT #6 F53A3 1181 113 CIP1 closely related to cadmium-induced protein CIP1 21.63 2.88 1.71 16.67 12.33 11 F49A8 937 157 hypothetical protein 2.47 3.16 1.83 2.21 1.61 J43A12 5940 207 Cell motility/budding/cell division | Cell wall components 4.26 1.39 4.01 2.2 3.71 9.51 F27F10 2686 240 conserved hypothetical membrane protein Unknown process and function 1.27 1.53 1.48 1.72 1.59 2.34 F53F4 3896 419 hypothetical protein Miscellaneous 3.8 3.18 4.52 2.15 2.12 F51C9 425 629 aryl-alcohol dehydrogenase Oxidoreductases | General metabolism 4.81 8.22 4.76 F50F5 3635 756 SAP7 secreted aspartyl proteinase 7 Secreted/degradative enzymes | General metabolism 2.53 4.94 2.94 J26H8 1137 797 BAT2 branched-chain amino acid transaminase Amino acid biosynthesis/metabolism/transport | General metabolism 1.74 1.62 1.45 1.74 1.67 1.09 J39D4 3850 839 Unknown process and function 1.53 1.4 1.49 1.54 1.59 1.72 F58B11 2319 1038 hypothetical protein 2.58 1.97 1.64 2.46 1.24 1.79 F51G1 3472 1120 hypothetical protein 3.94 2.98 1.6 2.47 1 2.26 F25G5 3134 1159 MET23 homoserine O-acetyltransferase Amino acid biosynthesis/metabolism/transport | General metabolism 4.85 2.04 1.56 1.48 3.22 F34B6 4623 1186 hypothetical protein 1.36 1.59 1.87 1.36 1.41 2.45 F40G7 2943 1202 hypothetical protein 2.9 2.71 3.17 F23C12 1385 1302 2.09 4.07 10.17 6.94 F55E9 4883 1321 HWP1 hyphal wall protein Cell motility/budding/cell division | Cell wall components 95.76 75.58 25.04 47.5 69 21.5 Op1D8 4889 1327 RBT1 "repressed by Tup1, related to HWP1" Cell motility/budding/cell division | Cell wall components 30.02 22.01 100.9 F37D9 7125 1448 APT1 adenine phosphoribosyltransferase General metabolism 2.14 2.06 1.58 1.59 1.13 1.43 F15D9 7113 1460 QNS1 glutamine-dependent NAD(+) synthetase Miscellaneous 1.32 1.5 1.46 1.22 1.42 F2A11 2868 1769 PLP2 phosducin-like protein | GTPase inhibitor Transcription factors/chromatin/DNA-binding | Signaling/kinases/phosphatases | General metabolism 1.45 1.84 1.59 2.1 5.47 J14H2 1816 ALS3 Cell wall components 99.39 156.4 62.93 21.2 29.5 24.8 F1A3 1326 1822 UME6 transcriptional regulator of early meiotic genes Transcription factors/chromatin/DNA-binding | Cell cycle | General metabolism 7.05 4.54 2.8 2.44 2.23 5.29 J25B6 1260 1860 hypothetical protein 2.91 2.08 1.49 2.5 1.22 1.88 F13G5 6364 1995 ER/Golgi/secretion | Sugar/polysacchride metabolism | General metabolism 2.28 1.85 1.65 1.61 2.64 1.85 J24D12 592 2028 MXR1 peptide methionine sulfoxide reductase Oxidative stress | Stress response | Oxidoreductases | General metabolism 2.49 2.42 2.5 1.9 2.95 F61E1 5968 2029 DNA metabolism/repair | Stress response | Cell cycle | General metabolism 1.82 1.23 1.53 1.94 2.34 F67B5 7495 2060 SOD5 copper-zinc superoxide dismutase 12.25 39.42 21.11 25.35 93.56 28.24 F11G7 5578 2330 UTP6 U3 snoRNP protein RNA metabolism | General metabolism 1.68 1.18 1.47 1.51 1.46 1.5 J5F3 1377 2355 ALS10 agglutinin-like protein Cell wall components 98.92 141.7 42.87 17.8 41.96 32.35 F63H1 8497 2445 Amino acid biosynthesis/metabolism/transport 2.07 5.85 3.13 2.49 J26B4 3561 2459 hypothetical protein Miscellaneous 1.91 1.55 1.63 2.06 2.74 F63F11 4970 2465 hypothetical protein DNA metabolism/repair | Stress response | Cell cycle | General metabolism 2.74 1.75 2.09 1.73 3.51 F18E10 3911 2506 3.75 1.01 5.05 J36F5 4100 2598 1.79 1.39 1.78 2.07 1.93 2.32 J6F5 5481 2693 URE1 nitrogen catabolite repression regulator and prion generator Transcription factors/chromatin/DNA-binding | General metabolism 3.65 1.95 1.73 2.5 J26A1 5483 2695 UBR1 ubiquitin-protein ligase ER/Golgi/secretion | General metabolism 1.98 1.25 1.61 1.55 1.34 1.5 F12G9 2520 2728 RAD24 cell cycle checkpoint and nucleotide excision repair protein DNA metabolism/repair | Stress response | Cell cycle | General metabolism 2.33 1.48 2.44 1.57 2.94 J35G9 4586 2805 2.19 1.29 1.6 1.52 1.27 2.11 F31G10 6119 2903 conserved hypothetical protein 8.37 3.96 3.98 4.61 1.18 2.81 J11C10 6669 2947 SNZ1 stationary phase protein General metabolism 1.11 2.39 2.02 2.15 2.22 3.71 J10F5 7750 3013 CDC12 septin Cell motility/budding/cell division 2.22 0.99 2.11 2.18 1.56 2.97 F68F6 7755 3018 conserved hypothetical protein DNA metabolism/repair | Transcription factors/chromatin/DNA-binding | General metabolism 8.25 11.08 8.11 4.67 4 4.86 F14H9 4392 3207 CCN1 G1 cyclin Cell cycle | Signaling/kinases/phosphatases 2.09 1.91 1.29 1.67 1.82 3.26 J52E4 8258 3256 Oxidative stress | Transcription factors/chromatin/DNA-binding | Stress response | Signaling/kinases/phosphatases | Osmotic stress | General metabolism 2.32 2.13 2.56 J45B8 7189 3294 MBF1 multiprotein bridging factor Transcription factors/chromatin/DNA-binding | General metabolism 1.86 1.06 1.74 1.77 1.76 1.62 J40A10 7204 3309 hypothetical GAG protein 2.65 2.05 2.34 1.87 J5G4 2886 3374 ECE1 secreted cell elongation protein 67.73 65.61 46.73 9 8 7.85 F5H8 2791 3449 highly conserved hypothetical protein Unknown process and function 3.05 1.07 2.62 2.37 1.53 3.3 F57F5 994 3460 hypothetical protein 1.74 3.04 1.76 2.86 1.88 3.66 F39D3 664 3649 FES1 adenyl-nucleotide exchange factor activity General metabolism 1.4 1.23 1.7 2.52 1.45 2.18 J43F7 2879 3698 hypothetical protein Unknown process and function 2.44 1.51 5.76 4.11 1.77 5.82 M11F8 3954 3765 RAX2 membrane protein involved in bipolar budding Cell motility/budding/cell division | Cell wall components 1.65 1.42 2.06 F13G1 3952 3767 PEP1 receptor for sorting of vacuolar proteins ER/Golgi/secretion | Vacuolar | General metabolism 1.57 1.52 1.39 1.47 1.56 1.27 Op1H3 3829 Miscellaneous 3.67 5.01 4.94 6.32 7.01 F41C10 7538 3843 SEC66 signal recognition particle receptor | ER protein-translocation complex subunit ER/Golgi/secretion | General metabolism 3.1 1.05 2.79 4.04 2.51 7 F9C12 5146 3902 conserved hypothetical protein 1.37 2.3 5.21 F68E8 7422 4009 CNB1 "protein phosphatase, Calcineurin B" Signaling/kinases/phosphatases 2.89 1.76 2.08 2.49 2.78 Op1E2 7439 4026 HIS1 ATP phosphoribosyltransferase Amino acid biosynthesis/metabolism/transport | General metabolism 1.68 1.91 1.87 2.42 2.32 J6H3 6854 4082 DDR48 flocculent specific protein | contains NNDDNSYG motif DNA metabolism/repair | Stress response | General metabolism 37.97 52.74 16.97 9 8.68 20.69 F15C10 3493 4264 hypothetical protein 5.87 1.92 4.46 3.71 4.15 F20C2 3168 4316 conserved hypothetical protein Mitochondrial 1.71 1.19 2.03 1.8 2.67 5.43 F54E6 1698 4334 hypothetical protein Cell motility/budding/cell division | Cell wall components 2.32 6.22 4.63 J6F2 4542 4377 KRE1 "cell wall beta-1,6-glucan assembly" 2.56 2.93 5.36 2.39 J14D12 4226 4413 Cell motility/budding/cell division | Cell cycle 1.54 1.58 1.67 1.86 1.16 1.84 J19H10 4310 4477 IFD4 aryl-alcohol dehydrogenase Oxidoreductases | General metabolism 19 5.11 4.46 3.5 1 2.45 F62B7 5001 4510 IFA4 leucine rich repeat gene family protein 2.32 2.5 2.08 2.73 1.63 1.45 F23C5 3182 4720 CTR2 copper transpport protein Copper metabolism | Vacuolar 1.41 1.57 1.5 1.48 1.6 1.81 F12G7 4601 4754 Oxidoreductases | Sugar/polysacchride metabolism | General metabolism 3.11 1.53 1.94 2.75 1.33 2.85 M4A7 4898 4788 "ARG5,6" N-acetyl-gamma-glutamyl-phosphate reductase and acetylglutamate kinase | N-acetyl-gamma-glutamyl-phosphate reductase and acetylglutamate kinase | acetylglutamate kinase and acetylglutamyl-phosphate reductase Amino acid biosynthesis/metabolism/transport | Oxidoreductases | Mitochondrial | General metabolism 1.4 1.74 2.13 2 2.42 3.27 J43B11 2025 4900 MNN13 mannosyltransferase Sugar/polysacchride metabolism | General metabolism 2.12 1.79 2.54 3.02 3.35 9.3 F64G1 6045 4945 MSH6 DNA mismatch repair protein DNA metabolism/repair | Stress response | Cell cycle | General metabolism 2.23 1.44 1.82 1.36 1.39 3.05 F41D5 7998 5011 KAR9 "microtubule orientation, karyogamy protein" Cell motility/budding/cell division | Cell cycle 3.5 1.74 2.76 1.6 1.85 3.22 F19G3 7975 5034 conserved hypothetical protein Oxidative stress | Stress response | General metabolism 1.56 1.26 1.81 1.48 1.37 1.89 J25B2 6300 5076 PFY1 profilin Cell motility/budding/cell division | Stress response | Osmotic stress 3.29 3.12 2.17 2.15 1.16 2.37 J14F12 6346 5104 LTP1 protein-tyrosine-phosphatase Signaling/kinases/phosphatases | General metabolism 1.58 1.89 1.58 F28C5 3411 5195 URA6 uridylate kinase General metabolism 1.69 1.42 1.62 1.61 1.19 1.58 J8D7 7677 5265 KIP4 kinesin heavy chain homolog Cell motility/budding/cell division | Cell cycle 8.3 3.57 3.33 3.19 F49G2 3244 5567 POP4 rRNA and tRNA processing RNA metabolism | General metabolism 7.95 4.33 5.51 9.89 F55B2 1047 5614 DNA metabolism/repair | Cell cycle | RNA metabolism | General metabolism 1.88 1.33 1.79 2.13 2.95 3.63 J40H4 4779 5620 Unknown process and function 7.31 3.11 2.26 2.06 F13H2 4780 5621 conserved hypothetical protein Unknown process and function 6.65 5.41 2.81 5.59 1.5 2.23 J19G9 4503 5634 FRP1 ferric reductase Iron metabolism | Oxidoreductases 4.07 2.86 1.69 2.8 2.12 1.12 J4G11 4915 5736 ALS5 agglutinin Unknown process and function 5.51 11.27 6.45 3.11 3.1 2.45 M11B9 2112 5741 ALS1 Cell wall components 1.12 17.3 3.27 5.16 14.43 11.9 J31H4 6198 5760 IHD1 Induced in Hyphal Development | membrane protein Secreted/degradative enzymes | Cell wall components | Sugar/polysacchride metabolism 2.8 5.36 3.65 4.3 4.32 2.9 J32B12 6644 5811 Amino acid biosynthesis/metabolism/transport | General metabolism 1.99 2.22 2.36 J24D6 5056 5864 URK1 uridine kinase General metabolism 1.48 1.26 2.09 1.81 J22H8 9064 5973 PHB2 mitochondrial prohibitin Mitochondrial | General metabolism 1.9 1.5 1.82 2.13 1.06 1.92 F33E4 7579 6035 ubiquinone oxidoreductase 1.63 1.48 1.78 2.8 2.84 4.66 F30B1 5099 6118 conserved hypothetical protein 2.02 1.8 2.05 1.94 1.3 3.1 F63F5 5666 6148 USO2 intracellular protein transport ER/Golgi/secretion | General metabolism 18.33 4.05 4.07 8.04 10.5 7.76 F17A10 5425 6199 HCS1 DNA helicase A DNA metabolism/repair | Cell cycle | General metabolism 3.23 1.5 2.64 F68A2 5444 6294 MYO1 class II myosin heavy chain Cell motility/budding/cell division | Stress response | Osmotic stress 3.24 0.9 2.17 1.94 2.13 J27G10 7834 6420 hypothetical membrane protein with repeated hydrophobic/hydrophilic domains Cell wall components 3.81 7.35 2.51 5.3 14.76 5.08 J10C3 7556 6568 RHC18 involved in recombination repair DNA metabolism/repair | Stress response | General metabolism 5.12 1.17 2.37 3.34 2.31 6.35 F23F5 6214 6602 conserved hypothetical protein Mitochondrial 1.87 1.22 1.84 2.77 2.06 F11G3 6814 6705 conserved hypothetical protein Unknown process and function 3.54 2.39 1.93 3.02 4.13 11.14 F38F10 6885 6736 conserved hypothetical protein Mitochondrial 1.55 1.66 1.86 1.24 2.3 2.31 J22E7 7133 6869 AST2 mitochondrial inner membrane protease | involved in targeting of plasma membrane [H+] ATPase Unknown process and function 1.71 1.19 1.77 2.37 2.67 3.12 J3F4 7153 6889 MKK2 protein kinase of the MAP kinase kinase (MEK) family Signaling/kinases/phosphatases | General metabolism 2.57 1.14 2.26 J40B9 7177 6913 GCN2 eIF2-alpha kinase | ser/thr protein kinase Amino acid biosynthesis/metabolism/transport | Signaling/kinases/phosphatases | General metabolism 2.66 1.34 1.76 F68F10 8090 7190 OGG1 8-oxoguanine DNA glycosylase | DNA repair DNA metabolism/repair | Stress response | Sugar/polysacchride metabolism | Mitochondrial | General metabolism 3.62 4.04 3.13 J6D2 8403 7322 conserved hypothetical protein Unknown process and function 2.72 1.16 1.89 1.99 1.3 1.97 J22F6 8405 7324 THI13 pyrimidine precursor biosynthesis enzyme General metabolism 5.03 2.68 1.35 1.96 1.42 2.81 F28D7 8509 7349 CHS4 chitin synthase regulatory factor Stress response | Sugar/polysacchride metabolism | General metabolism | Osmotic stress 2.55 1.52 2.67 1.95 1.17 1.84 F61H9 8510 7350 highly charged conserved protein of unknown function Unknown process and function 3.39 3.53 2.07 2.65 2.81 4.33 J19E6 8585 7425 UNG1 uracil DNA glycosylase DNA metabolism/repair | Stress response | Sugar/polysacchride metabolism | Mitochondrial | General metabolism 3.13 1.36 2.08 2.17 1.83 3.19 J18H1 8608 7448 LYS9 "seventh step in lysine biosynthesis pathway | saccharopine dehydrogenase (NADP+, L-glutamate forming)" Amino acid biosynthesis/metabolism/transport | Oxidoreductases | General metabolism 2.16 2.65 1.92 2.22 1.86 3 J14H6 8712 7460 conserved hypothetical protein Unknown process and function 4.27 7.2 13.29 F38B8 8721 7469 ARG1 argininosuccinate synthetase Amino acid biosynthesis/metabolism/transport | General metabolism 2.27 3.36 2.11 6.25 8.5 10.49 J14B8 8729 7477 YRB1 GTPase-activating protein Cell cycle | General metabolism 2.62 0.9 2.48 4.04 2.13 4.4 F48E5 8753 7501 NAP1 nucleosome assembly protein I Cell motility/budding/cell division | Transcription factors/chromatin/DNA-binding | DNA metabolism/repair | Cell cycle | General metabolism 2.46 1.06 1.92 2.75 1.6 1.81 F48E10 8756 7504 conserved hypothetical protein 5.26 2.2 2.24 3.5 11.1 17.93 F48A4 8901 7553 conserved hypothetical protein 5.21 3.85 1.55 6.05 J47B7 8909 7561 putative serine/threonine-protein kinase Stress response | General metabolism 2.02 3.75 2.06 2.16 2.29 F47H8 8911 7563 BET2 geranylgeranyltransferase type II beta subunit General metabolism 1.83 1.79 1.58 1.94 1.11 J30A7 8931 7583 potential fungal Zn(2)-Cys(6) binuclear cluster domain 2.82 1.71 1.72 1.52 1.44 1.64 J2A4 8958 7610 PTP3 protein tyrosine phosphatase Transcription factors/chromatin/DNA-binding | Signaling/kinases/phosphatases | Osmotic stress | General metabolism 4.68 1.01 2.51 1.78 4.34 4.45 F48G2 9002 7654 CPR6 cyclophilin related to the mammalian CyP-40 General metabolism 1.77 1.4 1.38 1.6 1.29 1.4 J34D2 2959 7818 1.49 1.76 1.98 J36H5 no orf6 1.82 3.17 2.79 2.08 2.25 J6H12 no orf6 1.74 1.47 1.61 1.79 J45D2 2392 2240 22.43 14.27 4.7 2.67 1.61 2.57 J52C5 3486 4271 2.98 1.53 2.01 2 2.31 2.27 SAM False Discovery Rate (FDR) = 0.78%