Locus IdGene NameOrganismDescription
orf19.1667Candida albicans SC5314Protein with a predicted SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily domain; Hap43-repressed gene
orf19.1669AFG3Candida albicans SC5314Similar to S. cerevisiae Afg3p, a subunit of the mitochondrial inner membrane m-AAA protease; likely to be essential for growth, based on an insertional mutagenesis strategy
orf19.510Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.514SNP3Candida albicans SC5314Putative U6 snRNA-associated protein; transcript regulated by Mig1
orf19.7550IFA14Candida albicans SC5314Putative LPF family protein; Plc1-regulated; induced by alpha pheromone in SpiderM medium
orf19.515Candida albicans SC5314Protein of unknown function
orf19.7551ALO1Candida albicans SC5314D-Arabinono-1,4-lactone oxidase involved in biosynthesis of dehydro-D-arabinono-1,4-lactone, which has a protective role against oxidative damage; plasma membrane-localized;required for full virulence in a mouse model of systemic infection
orf19.516Candida albicans SC5314S. cerevisiae ortholog Rft1p has role in glycolipid translocation, protein N-linked glycosylation and localizes to endoplasmic reticulum membrane; regulated by Sef1p-, Sfu1p-, and Hap43p
orf19.7552Candida albicans SC5314Putative U3-containing small subunit processome complex protein; Hap43-induced gene; repressed in core stress response; Spider biofilm induced
orf19.517HAP31Candida albicans SC5314Putative CCAAT-binding transcription factor; regulates CYC1; required for resistance to rapamycin, copper; induced in high iron; repressed in low iron; Sef1, Sfu1, and Hap43 regulated; rat catheter and Spider biofilm induced
orf19.7553Candida albicans SC5314Protein of unknown function; rat catheter biofilm repressed
orf19.4210Candida albicans SC5314Protein of unknown function
orf19.518Candida albicans SC5314Protein of unknown function
orf19.7554Candida albicans SC5314Transporter; similar to the Sit1 siderophore transporter; induced by nitric oxide independent of Yhb1; repressed during chlamydospore formation in C. albicans and C. dubliniensis; rat catheter biofilm repressed
orf19.4211Candida albicans SC5314Multicopper oxidase; for growth in low iron, prostaglandin E2 synthesis; ketoconazole/caspofungin/amphotericin B repressed; Sef1/Sfu1/Hap43 regulated; reports differ if functional homolog of ScFet3; rat catheter and Spider biofilm induced
orf19.7555Candida albicans SC5314Protein of unknown function
orf19.4212FET99Candida albicans SC5314Multicopper oxidase family protein; similar to S. cerevisiae Fet3; does not complement S. cerevisiae fet3 mutant growth under low-iron; iron-repressed; regulated by Tup1, Rim101; flow model biofilm induced; Spider biofilm repressed
orf19.7557FGR46Candida albicans SC5314Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth
orf19.4214Candida albicans SC5314Protein of unknown function
orf19.4215FET34Candida albicans SC5314Multicopper ferroxidase; induced by low iron, ciclopirox olamine, ketoconazole, hypoxia; alkaline induced by Rim101; repressed in fluconazole-resistant isolate; Sfu1, Hog1 repressed; complements S. cerevisiae fet3; Spider biofilm induced
Locus IdGene NameOrganismDescription
orf19.4219RIX7Candida albicans SC5314Putative ATPase of the AAA family; role in ribosomal subunit export from the nucleus; mutation impairs hyphal growth and biofilm formation
orf19.580Candida albicans SC5314Protein of unknown function; mutants are viable; Spider biofilm induced
orf19.581Candida albicans SC5314Putative RNA-binding protein; transcript is upregulated in an RHE model of oral candidiasis
orf19.583Candida albicans SC5314Indoleamine 2,3-dioxygenase (IDO); rate-limiting enzyme of tryptophan catabolism via kynurenine; enzyme inhibition by 1-methyl-D,L-tryptophan increases hyphal growth; expressed in yeast and hyphae; rat catheter and Spider biofilm induced
orf19.3622ANP1Candida albicans SC5314Putative mannosyltransferase of Golgi; member of Mnn9p family; similar to S. cerevisiae Anp1p; fungal-specific (no human or murine homolog)
orf19.6966Candida albicans SC5314Protein of unknown function
orf19.3623SMC2Candida albicans SC5314Protein similar to S. cerevisiae Smc2p, which is a component of the condensin complex involved in mitotic chromosome condensation; induced under hydroxyurea treatment
orf19.6967USO6Candida albicans SC5314Putative vesicular transport protein; transcript induced by filamentous growth; rat catheter biofilm repressed
orf19.587Candida albicans SC5314Protein of unknown function
orf19.6968Candida albicans SC5314Protein of unknown function; Hog1-repressed; Spider biofilm induced
orf19.589VPS21Candida albicans SC5314Late endosomal Rab small monomeric GTPase involved in transport of endocytosed proteins to the vacuole; involved in filamentous growth and virulence; Spider biofilm induced
orf19.4283Candida albicans SC5314Protein of unknown function
orf19.4284BUR2Candida albicans SC5314Protein with similarity to S. cerevisiae Bur2p, contains a cyclin domain; not required for wild-type hyphal growth, adherence to buccal epithelial cells, or virulence in mouse systemic infection
orf19.4286Candida albicans SC5314Protein of unknown function; flow model biofilm induced; Spider biofilm induced
orf19.4288CTA7Candida albicans SC5314Zn(II)2Cys6 transcription factor; activates transcription in 1-hybrid assay in S. cerevisiae; has similarity to S. cerevisiae Stb4
orf19.6970Candida albicans SC5314Protein of unknown function
orf19.6971DIE2Candida albicans SC5314Protein of unknown function
orf19.592Candida albicans SC5314Ortholog of S. cerevisiae YNL092W and S. pombe SPBC1778.07; a putative N2227-like methyltransferase; Hap43-repressed gene
orf19.3630RRP8Candida albicans SC5314Ribosomal protein; Hap43-induced; F-12/CO2 early biofilm and rat catheter biofilm induced
orf19.3631STN1Candida albicans SC5314Protein involved in telomere maintenance; forms a complex with Ten1p
Locus IdGene NameOrganismDescription
orf19.6976Candida albicans SC5314Predicted MFS membrane transporter; member of the proton coupled folate transporter/heme carrier protein family; virulence-group-correlated expression; Spider biofilm induced
orf19.6977GPI1Candida albicans SC5314Putative protein of GPI synthesis; expression is reduced in a fluconazole-resistant isolate
orf19.4290TRR1Candida albicans SC5314Thioredoxin reductase; regulated by Tsa1/Tsa1B, Hap43; induced by nitric oxide, peroxide; oxidative stress-induce via Cap1; induced by human neutrophils; stationary phase enriched protein
orf19.5640PEX5Candida albicans SC5314Pex5p family protein; required for PTS1-mediated peroxisomal protein import, fatty acid beta-oxidation; similar to S. cerevisiae Pas10p peroxisomal targeting receptor; macrophage/pseudohyphal-repressed; Hap43p-repressed
orf19.5641CAR2Candida albicans SC5314Ornithine aminotransferase; arginine metabolism; alkaline induced; mutant sensitivite to toxic ergosterol analog, to amphotericin B; exponential and stationary phase yeast; flow model biofilm induced; rat catheter, Spider biofilm repressed
orf19.5643ECM7Candida albicans SC5314Protein involved in control of calcium homeostasis and oxidative stress response; mutants show defects in hyphal growth
orf19.5644Candida albicans SC5314Protein of unknown function
orf19.2301Candida albicans SC5314Protein of unknown function
orf19.5645MET15Candida albicans SC5314O-acetylhomoserine O-acetylserine sulfhydrylase; sulfur amino acid synthesis; immunogenic; Hog1, adherence-induced; brown color of mutant in Pb(2+) medium a visual selection; chlamydospore formation induced, F-12/CO2 biofilm induced
orf19.2302Candida albicans SC5314Protein of unknown function
orf19.5646Candida albicans SC5314Protein of unknown function
orf19.2303FGR16Candida albicans SC5314Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth; fluconazole-downregulated
orf19.2304Candida albicans SC5314Protein similar to S. cerevisiae Gvp36p; transposon mutation affects filamentous growth
orf19.5648Candida albicans SC5314Protein of unknown function
orf19.2306Candida albicans SC5314Protein of unknown function
orf19.2308Candida albicans SC5314Putative 6-phosphofructo-2-kinase; catalyzes synthesis of fructose-2,6-bisphosphate; Hap43-repressed; flow model, rat catheter and Spider biofilm induced
orf19.71Candida albicans SC5314Protein of unknown function
orf19.73Candida albicans SC5314Putative metalloprotease; associates with ribosomes and is involved in ribosome biogenesis; Spider biofilm induced
orf19.75Candida albicans SC5314Predicted exocyst component; ortholog of S. cerevisiae Sec5p; merged with orf19.74 in Assembly 21
orf19.5650PRO3Candida albicans SC5314Delta 1-pyrroline-5-carboxylate reductase; protein induced during the mating process; alkaline induced; stationary phase enriched protein; Spider biofilm repressed
Locus IdGene NameOrganismDescription
orf19.5653ATP2Candida albicans SC5314F1 beta subunit of F1F0 ATPase complex; antigenic in human, mice; induced by ciclopirox olamine; caspofungin repressed; macrophage/pseudohyphal-induced; detected during exponential and stationary growth phases; Spider biofilm repressed
orf19.2310Candida albicans SC5314Predicted single-stranded nucleic acid binding protein; flow model biofilm induced
orf19.1671UTR2Candida albicans SC5314Putative GPI anchored cell wall glycosidase; role in adhesion, hyphal growth on Spider (not serum) medium; chitin-binding, glycosyl hydrolase domains; induced during cell wall regeneration; mRNA in yeast-form cells; Spider biofilm induced
orf19.1673PPT1Candida albicans SC5314Putative serine/threonine phosphatase; induced in high iron
orf19.1674CDC53Candida albicans SC5314Cullin, a scaffold subunit of the SCF ubiquitin-ligase complexes; depletion leads to increased filamentous growth and premature cell death
orf19.1676Candida albicans SC5314Predicted potassium ion transporter; Spider biofilm induced
orf19.1678Candida albicans SC5314Protein of unknown function; transcript detected on high-resolution tiling arrays
orf19.520Candida albicans SC5314Protein of unknown function
orf19.6900Candida albicans SC5314Protein of unknown function
orf19.522PIM1Candida albicans SC5314ATP-dependent Lon protease; role in degradation of misfolded proteins in mitochondria, biogenesis and maintenance of mitochondria; rat catheter biofilm induced
orf19.6902DBP7Candida albicans SC5314Putative ATP-dependent DEAD-box RNA helicase; Hap43-induced; rat catheter biofilm induced
orf19.524Candida albicans SC5314Protein of unknown function
orf19.6904GCN3Candida albicans SC5314Putative translation initiator; downregulated in the presence of human whole blood or polymorphonuclear (PMN) cells
orf19.6905Candida albicans SC5314Protein of unknown function
orf19.526NHP2Candida albicans SC5314Putative H/ACA snoRNP protein; macrophage/pseudohyphal-induced
orf19.7564DPB2Candida albicans SC5314Probable subunit of DNA polymerase II (DNA polymerase epsilon), similar to S. cerevisiae Dpb2p; essential for viability; rat catheter biofilm induced
orf19.6908Candida albicans SC5314Dihydrofolate synthetase involved in folic acid biosynthesis
orf19.4221ORC4Candida albicans SC5314Phosphorylated protein similar to S. cerevisiae Orc4, subunit of the origin recognition complex (ORC); induced by alpha pheromone in SpiderM medium
orf19.7565GNP3Candida albicans SC5314Putative high-affinity glutamine permease; fungal-specific (no human or murine homolog)
orf19.6909Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.4223GCD11Candida albicans SC5314Gamma subunit of translation initiation factor eIF2; involved in identification of the start codon; likely essential for growth, based on an insertional mutagenesis strategy; Spider biofilm repressed
orf19.7567Candida albicans SC5314Protein of unknown function; induced by alpha pheromone in SpiderM medium
orf19.4225LEU3Candida albicans SC5314Zn(II)2Cys6 transcription factor; predicted regulator branched-c ofhain amino acid biosynthesis genes; alkaline induced; induced by Mnl1 under weak acid stress; required for yeast cell adherence to silicone substrate; Spider biofilm induced
orf19.6978Candida albicans SC5314Planktonic growth-induced gene
orf19.3635Candida albicans SC5314Protein of unknown function
orf19.6979Candida albicans SC5314Protein of unknown function
orf19.4292Candida albicans SC5314Protein of unknown function
orf19.4293Candida albicans SC5314Protein of unknown function
orf19.4294Candida albicans SC5314Protein of unknown function
orf19.4295Candida albicans SC5314Protein of unknown function
orf19.3639Candida albicans SC5314Protein of unknown function
orf19.4299MSW1Candida albicans SC5314Protein similar to S. cerevisiae Msw1p, which is mitochondrial tryptophanyl-tRNA synthetase; Hap43p-repressed gene; likely to be essential for growth, based on an insertional mutagenesis strategy
orf19.6980Candida albicans SC5314Protein of unknown function
orf19.6982Candida albicans SC5314Protein of unknown function
orf19.6984Candida albicans SC5314Protein of unknown function
orf19.6985TEA1Candida albicans SC5314Putative transcription factor with zinc cluster DNA-binding motif; has similarity to S. cerevisiae Tea1p; Hap43p-repressed gene
orf19.3642SUN41Candida albicans SC5314Cell wall glycosidase; role in biofilm formation and cell separation; possibly secreted; hypoxia, hyphal induced; caspofungin repressed; Efg1, Cph1 regulated; O-glycosylated, possible Kex2 substrate; 5'-UTR intron; Spider biofilm induced
orf19.6986Candida albicans SC5314Protein of unknown function
orf19.3643Candida albicans SC5314Protein of unknown function; Hap43-repressed gene
orf19.6987DNM1Candida albicans SC5314Putative dynamin-related GTPase; transcript upregulated inbRHE model of oral candidiasis; transcript regulated by Nrg1, Mig1, and Tup1
Locus IdGene NameOrganismDescription
orf19.6989Candida albicans SC5314Putative U2 snRNP-associated protein; Spider biofilm induced
orf19.3646CTR1Candida albicans SC5314Copper transporter; transcribed in low copper; induced Mac1, Tye7, macrophage interaction, alkaline pH via Rim101; 17-beta-estradiol repressed; complements S. cerevisiae ctr1 ctr3 copper transport mutant; flow model/Spider biofilm induced
orf19.3647SEC8Candida albicans SC5314Predicted subunit of the exocyst complex, involved in exocytosis; localizes to a crescent on the surface of the hyphal tip
orf19.3648Candida albicans SC5314Protein of unknown function
orf19.2311RPL82Candida albicans SC5314Predicted ribosomal protein; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage
orf19.2312Candida albicans SC5314Protein similar to ferric reductase Fre10p; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.5657SWI1Candida albicans SC5314Protein involved in transcription regulation; ortholog of S. cerevisiae Swi1p, which is a subunit of the SWI/SNF chromatin remodeling complex; interacts with Snf2p; SWI/SNF complex is essential for hyphal growth and virulence
orf19.5658MNN10Candida albicans SC5314Protein of unknown function
orf19.2315RTG3Candida albicans SC5314Putative transcription factor with bZIP DNA-binding motif; mutants are sensitive to cations and antifungal drugs, and defective in filamentous growth
orf19.2317Candida albicans SC5314Protein of unknown function; induced by alpha pheromone in SpiderM medium
orf19.81Candida albicans SC5314Protein of unknown function
orf19.85GPX2Candida albicans SC5314Similar to glutathione peroxidase; induced in high iron; alkaline induced by Rim101; induced by alpha factor or interaction with macrophage; regulated by Efg1; caspofungin repressed; Spider biofilm induced
orf19.86Candida albicans SC5314Putative glutathione peroxidase; induced by peroxide, exposure to neutrophils and macrophage blood fractions; repressed during infection of macrophages; Spider biofilm induced; flow model biofilm repressed
orf19.88ILV5Candida albicans SC5314Ketol-acid reductoisomerase; antigenic; regulated by Gcn4; GlcNAc, amino acid starvation (3-AT)-induced; macrophage-repressed protein; protein present in exponential and stationary phase; flow model and Spider biofilm repressed
orf19.5660Candida albicans SC5314Protein of unknown function
orf19.5661PTC7Candida albicans SC5314Protein phosphatase, type 2C; has S/T phosphatase activity, Mn2+/Mg2+ dependent; predicted membrane-spanning segment and mitochondrion-targeting signal
orf19.5663RCH1Candida albicans SC5314Plasma membrane protein; involved in regulation of cytosolic calcium homeostasis; null mutation confers sensitivity to calcium and resistance to azoles and terbinafine; rat catheter biofilm induced
orf19.5664HOF1Candida albicans SC5314Ortholog of S. cerevisiae Hof1; a protein localized to the bud neck and required for cytokinesis in S. cerevisiae; periodic mRNA expression, peak at cell-cycle G2/M phase; mutant is viable
orf19.5665Candida albicans SC5314Protein of unknown function
orf19.2324UBA4Candida albicans SC5314Putative ubiquitin activating protein; Hap43-repressed; induced by prostaglandins; clade-associated gene expression
Locus IdGene NameOrganismDescription
orf19.2325Candida albicans SC5314Protein of unknown function
orf19.2326Candida albicans SC5314Protein of unknown function
orf19.95Candida albicans SC5314Protein of unknown function
orf19.97CAN1Candida albicans SC5314Basic amino acid permease; complements lysine transport mutation; 10 predicted transmembrane regions, 3 predicted N-glycosylation sites; phagocytosis by macrophages induces transcript; rat catheter, Spider and flow model biofilm induced
orf19.5672MEP2Candida albicans SC5314Ammonium permease and regulator of nitrogen starvation-induced filamentation; 11 predicted transmembrane regions; in low nitrogen cytoplasmic C-terminus activates Ras/cAMP and MAPK signal transduction pathways to induce filamentation
orf19.5674PGA10Candida albicans SC5314GPI anchored membrane protein; utilization of hemin and hemoglobin for Fe in host; Rim101 at ph8/hypoxia/ketoconazole/ciclopirox/hypha-induced; required for RPMI biofilm formation, Bcr1-induced in a/a biofilm; rat catheter biofilm repressed
orf19.2331ADA2Candida albicans SC5314Zinc finger and homeodomain transcriptional coactivator; role in cell wall integrity and in sensitivity to caspofungin; required for the normal transcriptional response to caspofungin; required for yeast cell adherence to silicone substrate
orf19.5675Candida albicans SC5314Protein involved in proteolytic control of sumoylated substrates; interacts with SUMO; member of the SWI/SNF family of DNA-dependent ATPases; Spider biofilm induced
orf19.2332Candida albicans SC5314Protein of unknown function
orf19.5676Candida albicans SC5314Protein of unknown function
orf19.2333Candida albicans SC5314Protein of unknown function
orf19.5677DUR4Candida albicans SC5314Putative urea permease; fungal-specific (no human or murine homolog); possibly an essential gene, disruptants not obtained by UAU1 method
orf19.2334BIG1Candida albicans SC5314Endoplasmic reticulum (ER) protein; ortholog of S. cerevisiae Big1; required for beta-1,6-glucan synthesis, filamentation, adhesion, and virulence; rat catheter biofilm repressed
orf19.5678Candida albicans SC5314Protein of unknown function
orf19.2337ALP1Candida albicans SC5314Cystine transporter; present in pathogenic yeasts (no human or murine homolog); Spider biofilm induced
orf19.5680Candida albicans SC5314Protein with predicted hydrolase domains; similar to a universal stress protein family protein; possibly essential, disruptants not obtained by UAU1 method; Spider biofilm repressed
orf19.5682Candida albicans SC5314Protein of unknown function
orf19.5683Candida albicans SC5314Putative integral membrane protein of unknown function; clade-associated gene expression; Spider biofilm induced
orf19.5684Candida albicans SC5314Protein of unknown function
orf19.2341HNT1Candida albicans SC5314Protein with similarity to protein kinase C inhibitor-I; protein level decreases in stationary phase cultures
Locus IdGene NameOrganismDescription
orf19.5685THS1Candida albicans SC5314Putative threonyl-tRNA synthetase; transcript regulated by Mig1 and Tup1; repressed upon phagocytosis by murine macrophages; stationary phase enriched protein; Spider biofilm repressed
orf19.5686Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.2343VPS23Candida albicans SC5314ESCRT I protein sorting complex protein; involved in proteolytic activation of Rim101, which regulates pH response; ortholog of S. cerevisiae Stp22/Vps23
orf19.5689Candida albicans SC5314Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; Spider biofilm repressed
orf19.2347MNN2Candida albicans SC5314Alpha-1,2-mannosyltransferase; similar to S. cerevisiae Mnn2; role in cell wall integrity, temperature sensitivity; iron utilization in low iron; Tn mutation affects filamentous growth; filament induced; increased chitin exposes beta-glucan
orf19.5691CDC11Candida albicans SC5314Septin; cell and hyphal morphology, agar-invasive growth, full virulence and kidney tissue invasion in mouse, but not kidney colonization, immunogenicity; hyphal and cell-cycle-regulated phosphorylation; rat catheter biofilm repressed
orf19.5692Candida albicans SC5314Protein of unknown function
orf19.2350Candida albicans SC5314Protein similar to S. cerevisiae Yor378w; MFS family transporter; transposon mutation affects filamentous growth; null mutants are viable; fungal-specific (no human or murine homolog)
orf19.2352Candida albicans SC5314Protein of unknown function
orf19.5698Candida albicans SC5314Putative mitochondrial ribosomal protein of the large subunit; transcript is upregulated in clinical isolates from HIV+ patients with oral candidiasis; Spider biofilm repressed
orf19.1700RPS7ACandida albicans SC5314Ribosomal protein S7; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage; Spider biofilm repressed
orf19.1702ARF3Candida albicans SC5314Similar to but not orthologous to S. cerevisae Arf3; transcript filament induced; Tup1 regulated; rat catheter biofilm repressed (see Locus History Note for Assembly 19 correction)
orf19.1704FOX3Candida albicans SC5314Putative peroxisomal 3-oxoacyl CoA thiolase; transcript regulated by white-opaque switch; Spider biofilm induced
orf19.2362Candida albicans SC5314Putative 90S preribosome component; Hap43p-induced gene; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.1706MET18Candida albicans SC5314Putative protein with a predicted role in nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription; Plc1p-regulated
orf19.1708Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.2368Candida albicans SC5314Predicted component of U5 snRNP; Spider biofilm induced
orf19.2369Candida albicans SC5314Protein of unknown function
orf19.1711END3Candida albicans SC5314Regulated by Gcn4p; induced in response to amino acid starvation (3-aminotriazole treatment)
orf19.2370DSL1Candida albicans SC5314Protein similar to S. cerevisiae Dsl1p, which is a member of the t-SNARE complex of the endoplasmic reticulum
Locus IdGene NameOrganismDescription
orf19.1716URA3Candida albicans SC5314Orotidine-5'-phosphate decarboxylase; pyrimidine biosynthesis; gene used as genetic marker; decreased expression when integrated at ectopic chromosomal locations can cause defects in hyphal growth and virulence; Spider biofilm repressed
orf19.1719SGA1Candida albicans SC5314Putative glucoamylase; induced in oralpharyngeal candidasis; rat catheter and Spider biofilm induced
orf19.2378Candida albicans SC5314Protein of unknown function
orf19.2379NOT4Candida albicans SC5314Putative E3 ubiquitin-protein ligase; required for maintenance, but not induction, of hyphal development; homozygous null mutant is avirulent in mouse systemic infection despite persistence in host; repressed in rat oral candidiasis
orf19.7600FDH3Candida albicans SC5314Glutathione-dependent formaldehyde dehydrogenase; glycine catabolism; repressed by Efg1 in yeast, not hyphal growth conditions; induced by Mnl1 under weak acid stress; Spider biofilm repressed
orf19.7601Candida albicans SC5314Putative mitochondrial 2' O-ribose methyltransferase; predicted role in methylation of U(2791) in 21S rRNA; Spider biofilm induced
orf19.7605PUP1Candida albicans SC5314Putative beta 2 subunit of the 20S proteasome; macrophage/pseudohyphal-repressed; Spider biofilm repressed
orf19.7606Candida albicans SC5314Protein of unknown function
orf19.7608Candida albicans SC5314Protein of unknown function; fluconazole-repressed; Spider biofilm induced
orf19.7609PGA11Candida albicans SC5314Putative GPI-anchored protein
orf19.1720Candida albicans SC5314Protein of unknown function
orf19.1721NCE103Candida albicans SC5314Carbonic anhydrase; converts of CO2 to bicarbonate; essential for virulence in host niches with limited CO2, normal white-opaque switch; Mnl1-induced in weak acid stress; Hap43-induced gene; F-12/CO2, rat catheter, Spider biofilm induced
orf19.1722Candida albicans SC5314Protein of unknown function
orf19.1725Candida albicans SC5314Putative adhesin-like protein
orf19.1727PMC1Candida albicans SC5314Vacuolar calcium P-type ATPase; transcript regulated by calcineurin and fluconazole; mutant shows increased resistance to fluconazole, lithium; increased sensitivity to calcium; Spider biofilm induced
orf19.1728Candida albicans SC5314Protein of unknown function
orf19.1729Candida albicans SC5314Putative transcription factor with zinc finger DNA-binding motif
orf19.2386Candida albicans SC5314Protein of unknown function
orf19.7610PTP3Candida albicans SC5314Putative protein tyrosine phosphatase; hypha induced; alkaline induced; regulated by Efg1, Ras1, cAMP pathways; mutants are viable; Spider biofilm induced; rat catheter biofilm repressed; flow model biofilm repressed
orf19.7611TRX1Candida albicans SC5314Thioredoxin; involved in response to reactive oxygen species; biofilm, benomyl, flucytosine, peroxide, Hap43 induced; amphotericin B, caspofungin repressed; induced by human neutrophils; macrophage-repressed gene
Locus IdGene NameOrganismDescription
orf19.7612CTM1Candida albicans SC5314Putative cytochrome c lysine methyltransferase; regulated by Gcn2 and Gcn4; transcript induced by Mnl1 under weak acid stress; early-stage flow model biofilm induced
orf19.7613HCR1Candida albicans SC5314Putative translation initiation factor; repressed upon phagocytosis by murine macrophage; Spider biofilm repressed
orf19.7615Candida albicans SC5314Protein involved in endoplasmic reticulum (ER) to Golgi vesicle-mediated transport; putative subunit of the transport protein particle (TRAPP) complex of the cis-Golgi; Spider biofilm induced
orf19.7617Candida albicans SC5314Protein of unknown function
orf19.1730Candida albicans SC5314HMG-box protein; Spider biofilm repressed
orf19.1734Candida albicans SC5314Putative ATPase and nucleosome spacing factor; heterozygous null mutant displays sensitivity to virgineone
orf19.1735Candida albicans SC5314Protein of unknown function
orf19.2392Candida albicans SC5314Protein of unknown function
orf19.2393Candida albicans SC5314Putative transcription factor with zinc finger DNA-binding motif
orf19.1737Candida albicans SC5314Protein of unknown function
orf19.1738UGP1Candida albicans SC5314UTP-glucose-1-phosphaturidyl transferase; localizes to yeast, not hyphal cell surface; Hog1-repressed; stationary phase enriched; induced in oralpharyngeal candidasis; rat catheter biofilm repressed; Bcr1-repressed in RPMI a/a biofilms
orf19.2396IFR2Candida albicans SC5314Zinc-binding dehydrogenase; induced by benomyl, ciclopirox olamine, alpha pheromone, Hap43; regulated by oxidative stress via Cap1, osmotic stress via Hog1; protein present in exponential and stationary phase; rat catheter biofilm repressed
orf19.2397Candida albicans SC5314Predicted membrane transporter, member of the anion:cation symporter (ACS) family, major facilitator superfamily (MFS); amphotericin B, caspofungin repressed; Hap43p-repressed
orf19.7620Candida albicans SC5314Protein of unknown function
orf19.7622SPT3Candida albicans SC5314Functional homolog of S. cerevisiae Spt3p; required for virulence in mouse systemic infection; homozygous null mutant is hyperfilamentous
orf19.7624Candida albicans SC5314Protein of unknown function
orf19.7627Candida albicans SC5314Protein of unknown function
orf19.7629Candida albicans SC5314Protein of unknown function
orf19.1743ACS1Candida albicans SC5314Acetyl-CoA synthetase; induced by human neutrophils; fluconazole-repressed; regulated by Nrg1/Mig1; colony morphology-related gene regulation by Ssn6; only in stationary phase cultures; rat catheter biofilm repressed, Spider biofilm induced
orf19.1745Candida albicans SC5314Protein of unknown function; Hap43-repressed gene
Locus IdGene NameOrganismDescription
orf19.1747KIP2Candida albicans SC5314Putative kinesin-related motor protein involved in mitotic spindle positioning; repressed by alpha pheromone in SpiderM medium; periodic mRNA expression, peak at cell-cycle G2/M phase
orf19.1748Candida albicans SC5314Protein of unknown function; shows colony morphology-related gene regulation by Ssn6
orf19.7632Candida albicans SC5314Protein of unknown function
orf19.7634MCD1Candida albicans SC5314Alpha-kleisin cohesin complex subunit; for sister chromatid cohesion in mitosis and meiosis; repressed by alpha pheromone in SpiderM medium; periodic cell-cycle expression; Hap43-repressed; rat catheter and Spider biofilm repressed
orf19.7637YHB4Candida albicans SC5314Protein related to flavohemoglobins; not required for wild-type nitric oxide resistance; has predicted globin, FAD-binding, and NAD(P)-binding domains but lacks some conserved residues of flavohemoglobins; Hap43p-repressed gene
orf19.1751SPT23Candida albicans SC5314Protein involved in regulation of unsaturated fatty acid biosynthesis; controls the expression of the Ole1p delta-9-fatty acid desaturase
orf19.1753PUS7Candida albicans SC5314Pseudouridine synthase; catalyzes pseudouridylation in U2 snRNA, 5S rRNA, cytoplasmic tRNAs and in pre-tRNA(Tyr); F-12/CO2 early biofilm induced
orf19.1755SET2Candida albicans SC5314Protein of unknown function
orf19.1756GPD1Candida albicans SC5314Glycerol-3-phosphate dehydrogenase; glycerol biosynthesis; regulated by Efg1; regulated by Tsa1, Tsa1B under H2O2 stress conditions; Sflow model and Spider biofilm induced
orf19.1757Candida albicans SC5314Putative C2H2 transcription factor; expression upregulated in clinical isolates from HIV+ patients with oral candidiasis; Spider biofilm induced
orf19.1759PHO23Candida albicans SC5314Protein of unknown function
orf19.600TRK1Candida albicans SC5314Potassium transporter; mediates K+ and Cl- influx; role in sensitivity to cationic antimicrobial peptides, not by direct uptake, possibly related to membrane permeability; contains 5' UTR intron; Spider biofilm induced
orf19.603IMP4Candida albicans SC5314Putative SSU processome component; Hap43-induced; repressed by prostaglandins; Spider biofilm induced
orf19.605Candida albicans SC5314Protein of unknown function
orf19.606Candida albicans SC5314Protein of unknown function; Hap43-induced; Spider biofilm induced
orf19.7643Candida albicans SC5314Protein of unknown function
orf19.7644Candida albicans SC5314Protein of unknown function
orf19.609Candida albicans SC5314Protein of unknown function; white cell specific transcript
orf19.7645Candida albicans SC5314Biotin protein ligase; catalyzes covalent attachment of biotin to biotin-dependent enzymes including acetyl CoA carboxylase and pyruvate carboxylase
orf19.7646Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.7648Candida albicans SC5314Protein of unknown function
orf19.4305Candida albicans SC5314Protein of unknown function
orf19.4307Candida albicans SC5314Protein of unknown function
orf19.4309GRP2Candida albicans SC5314Methylglyoxal reductase; regulation associated with azole resistance; induced in core stress response or by oxidative stress via Cap1, fluphenazine, benomyl, by Hap43 or with long term fluconazole treatment; Spider biofilm induced
orf19.1760RAS1Candida albicans SC5314RAS signal transduction GTPase; regulates cAMP and MAP kinase pathways; role in hyphal induction, virulence, apoptosis, heat-shock sensitivity; nonessential; plasma membrane-localized; complements viability of S. cerevisiae ras1 ras2 mutant
orf19.1762OCA1Candida albicans SC5314Putative protein phosphatase of the PTP family (tyrosine-specific); ortholog of S. cerevisiae Oca1; mutant is viable; mutant shows virulence defect
orf19.1764Candida albicans SC5314Protein of unknown function; rat catheter and Spider biofilm induced
orf19.1765Candida albicans SC5314Secreted protein; fluconazole-induced
orf19.1767Candida albicans SC5314Protein of unknown function
orf19.7650LTV1Candida albicans SC5314Putative GSE complex component; repressed by prostaglandins
orf19.4310Candida albicans SC5314Dubious open reading frame
orf19.4311YNK1Candida albicans SC5314Nucleoside diphosphate kinase (NDP kinase); homo-hexameric; soluble protein in hyphae; flucytosine induced; biofilm induced; macrophage-induced protein; stationary phase enriched protein; Spider biofilm repressed
orf19.4312Candida albicans SC5314Protein of unknown function
orf19.7657POP3Candida albicans SC5314Putative RNase MRP and nuclear RNase P component; decreased repressed by prostaglandins; Spider biofilm induced
orf19.4315Candida albicans SC5314Protein of unknown function
orf19.4317GRE3Candida albicans SC5314Putative D-xylose reductase; antigenic in murine systemic infection; soluble protein in hyphae; induced by farnesol, macrophage interaction and by Mnl1 under weak acid stress; stationary-phase enriched protein; Spider biofilm induced
orf19.1770CYC1Candida albicans SC5314Cytochrome c; complements defects of S. cerevisiae cyc1 cyc7 double mutant; induced in high iron; alkaline repressed; repressed by nitric oxide; Hap43-dependent repression in low iron; regulated by Sef1, Sfu1
orf19.1773RAP1Candida albicans SC5314Transcription factor; binds telomeres and regulatory sequences in DNA; involved in telomere maintenance; represses hyphal growth under yeast-favoring conditions; similar to (but shorter than) S. cerevisiae Rap1
orf19.1774Candida albicans SC5314Predicted dehydrogenase; transcript upregulated in an RHE model of oral candidiasis; virulence-group-correlated expression; Spider biofilm repressed
orf19.1776Candida albicans SC5314Putative pantetheine-phosphate adenylyltransferase (PPAT); which catalyzes 4th step in coenzyme A biosynthesis from pantothenate; rat catheter biofilm repressed
Locus IdGene NameOrganismDescription
orf19.1778Candida albicans SC5314Dubious open reading frame
orf19.1779MP65Candida albicans SC5314Cell surface mannoprotein; cell-wall glucan metabolism, adhesion; adhesin motif; O-glycosylation; induced by heat, germ tube formation, wall regeneration; mycelial antigen; diagnostic marker; fluconazole-repressed; Spider biofilm induced
orf19.7660VPS52Candida albicans SC5314Protein required for hyphal growth; has similarity to S. cerevisiae Vps52p
orf19.7661HMI1Candida albicans SC5314ATP-dependent 3' - 5' helicase involved in maintenance of mitochondrial DNA; ortholog of S. cerevisiae Hmi1; rat catheter biofilm repressed
orf19.7662Candida albicans SC5314Protein of unknown function
orf19.4320Candida albicans SC5314Protein of unknown function
orf19.7664Candida albicans SC5314Protein of unknown function
orf19.7665Candida albicans SC5314Protein of unknown function
orf19.4322DAP2Candida albicans SC5314Putative dipeptidyl aminopeptidase; transcriptionally regulated during macrophage response
orf19.7666Candida albicans SC5314Predicted membrane transporter, member of the anion:cation symporter (ACS) family, major facilitator superfamily (MFS)
orf19.4323Candida albicans SC5314Protein of unknown function
orf19.7667IAH1Candida albicans SC5314Protein similar to S. cerevisiae Iah1p, which is involved in acetate metabolism; mutation confers hypersensitivity to tunicamycin; transposon mutation affects filamentous growth
orf19.4324Candida albicans SC5314Protein of unknown function
orf19.7668MAL2Candida albicans SC5314Alpha-glucosidase; hydrolyzes sucrose for sucrose utilization; transcript regulated by Suc1, induced by maltose, repressed by glucose; Tn mutation affects filamentous growth; upregulated in RHE model; rat catheter and Spider biofilm induced
orf19.4325Candida albicans SC5314Protein of unknown function
orf19.4326Candida albicans SC5314Protein of unknown function
orf19.4328CCC2Candida albicans SC5314Copper-transporting P-type ATPase of Golgi; required for wild-type iron assimilation (indirect effect via Fet3p); induced by iron starvation, ciclopirox olamine; caspofungin repressed; not required for virulence in mouse systemic infection
orf19.1780Candida albicans SC5314Protein of unknown function
orf19.1789Candida albicans SC5314Protein of unknown function
orf19.633CRG1Candida albicans SC5314Methyltransferase involved in sphingolipid homeostasis, methylates a drug cantharidin; decreased expression in hyphae compared to yeast; expression regulated during planktonic growth; flow model biofilm induced; Hap43-repressed gene
Locus IdGene NameOrganismDescription
orf19.7672Candida albicans SC5314Protein of unknown function
orf19.637SDH2Candida albicans SC5314Succinate dehydrogenase, Fe-S subunit; localizes to surface of yeast cells, but not hyphae; induced in high iron and during log phase aerobic growth; repressed by nitric oxide, Hap43
orf19.7673Candida albicans SC5314Protein of unknown function
orf19.638FDH1Candida albicans SC5314Formate dehydrogenase; oxidizes formate to CO2; Mig1 regulated; induced by macrophages; fluconazole-repressed; repressed by Efg1 in yeast, not hyphal conditions; stationary phase enriched; rat catheter and Spider biofilm induced
orf19.7676XYL2Candida albicans SC5314D-xylulose reductase; immunogenic in mice; soluble protein in hyphae; induced by caspofungin, fluconazole, Hog1 and during cell wall regeneration; Mnl1-induced in weak acid stress; stationary phase enriched; flow model biofilm induced
orf19.4335TNA1Candida albicans SC5314Putative nicotinic acid transporter; detected at germ tube plasma membrane by mass spectrometry; transcript induced upon phagocytosis by macrophage; rat catheter biofilm induced
orf19.4337Candida albicans SC5314Predicted membrane transporter; monocarboxylate porter (MCP) family, major facilitator superfamily (MFS); Spider biofilm induced; rat catheter biofilm repressed
orf19.4339VPS4Candida albicans SC5314AAA-ATPase involved in transport from MVB to the vacuole and ESCRT-III complex disassembly; mutation decreases SAP secretion and virulence in murine intravenous infection; regulated by Gcn2p, Gcn4p; required for normal Rim8p processing
orf19.1791Candida albicans SC5314Putative protein with a predicted role in 60S ribosomal subunit biogenesis; Hap43p-induced gene; ortholog of S. cerevisiae MAK11
orf19.1792Candida albicans SC5314Protein of unknown function
orf19.1794Candida albicans SC5314Protein of unknown function
orf19.1796Candida albicans SC5314Putative glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; Spider biofilm repressed
orf19.1797Candida albicans SC5314D-arabinose 5-phosphate isomerase; has GutQ domain which is associated with phosphosugar binding; other biofilm induced; rat catheter and Spider biofilm induced; F-12/CO2 early biofilm induced
orf19.641Candida albicans SC5314Protein of unknown function
orf19.642Candida albicans SC5314Protein of unknown function
orf19.7680CTA26Candida albicans SC5314Putative transcription factor/activator; Med2 mediator complex ddomain; transcript is upregulated in an RHE model of oral candidiasis; member of a family of telomere-proximal genes; Efg1, Hap43-repressed
orf19.646GLN1Candida albicans SC5314Putative glutamate synthase; regulated by Tsa1, Tsa1B under H2O2 stress conditions; Spider biofilm induced
orf19.4341Candida albicans SC5314Protein of unknown function
orf19.1002Candida albicans SC5314Protein of unknown function; Hap43-repressed gene
orf19.4348MED14Candida albicans SC5314RNA polymerase II mediator complex subunit
Locus IdGene NameOrganismDescription
orf19.4349Candida albicans SC5314Protein of unknown function; transcript repressed by elevated CO2; Spider biofilm induced
orf19.1008Candida albicans SC5314Protein of unknown function
orf19.1009Candida albicans SC5314Protein of unknown function
orf19.653Candida albicans SC5314Dubious open reading frame
orf19.654Candida albicans SC5314Predicted protein only found in C. albicans and C. dubliniensis; highly induced during chlamydospore development
orf19.657SAM2Candida albicans SC5314S-adenosylmethionine synthetase; localizes to surface of hyphae, not yeast cells; alkaline, Hog1-induced; farnesol-downregulated; F-12/CO2 early biofilm induced; Spider biofilm repressed
orf19.1097ALS2Candida albicans SC5314ALS family protein; role in adhesion, biofilm formation, germ tube induction; expressed at infection of human buccal epithelial cells; putative GPI-anchor; induced by ketoconazole, low iron and at cell wall regeneration; regulated by Sfu1p
orf19.6321PGA48Candida albicans SC5314Putative GPI-anchored adhesin-like protein; similar to S. cerevisiae Spi1p, which is induced at stationary phase; transcript induced in high iron; flow model biofilm induced; Spider biofilm repressed
orf19.6322ARDCandida albicans SC5314D-arabitol dehydrogenase, NAD-dependent (ArDH); enzyme of D-arabitol and D-arabinose catabolism; D-arabitol is a marker for active infection in humans; rat catheter and Spider biofilm induced
orf19.6324VID27Candida albicans SC5314Protein similar to S. cerevisiae Vid27p; transposon mutation affects filamentous growth; mutation confers hypersensitivity to toxic ergosterol analog; fungal-specific (no human or murine homolog)
orf19.6326Candida albicans SC5314Protein of unknown function
orf19.6327HET1Candida albicans SC5314Putative sphingolipid transfer protein; involved in localization of glucosylceramide which is important for virulence; Spider biofilm repressed
orf19.3780Candida albicans SC5314Protein likely to be essential for growth, based on an insertional mutagenesis strategy
orf19.3782Candida albicans SC5314Predicted membrane transporter; member of the peptide-acetyl-coA transporter (PAT) family, major facilitator superfamily (MFS); induced by alpha pheromone in Spider medium
orf19.3785Candida albicans SC5314DnaJ chaperone domain protein; role in pre-mRNA splicing; Spider biofilm induced
orf19.3788SPC34Candida albicans SC5314Subunit of the Dam1 (DASH) complex, which acts in chromosome segregation by coupling kinetochores to spindle microtubules
orf19.6336PGA25Candida albicans SC5314Putative GPI-anchored adhesin-like protein; fluconazole-downregulated; induced in oralpharyngeal candidasis; Spider biofilm induced
orf19.6338Candida albicans SC5314Protein of unknown function
orf19.6339NRG2Candida albicans SC5314Transcription factor; transposon mutation affects filamentous growth
orf19.3792Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.3794CSR1Candida albicans SC5314Transcription factor; role in zinc homeostasis and regulation of Spider biofilm matrix; mutation affects filamentous growth; can suppress S. cerevisiae rok1 mutant inviability; Spider biofilm induced; mutants for abnormal Spider biofilms
orf19.3795AGP3Candida albicans SC5314Putative serine transporter; possible role in assimilation of sulfur; F-12/CO2 early biofilm induced
orf19.3797Candida albicans SC5314Protein of unknown function
orf19.3799Candida albicans SC5314Protein of unknown function
orf19.6341Candida albicans SC5314Protein of unknown function
orf19.6342Candida albicans SC5314Protein of unknown function
orf19.3000ORC1Candida albicans SC5314Putative origin recognition complex large subunit; essential for viability; similar to S. cerevisiae Orc1p origin recognition complex subunit
orf19.658GIN1Candida albicans SC5314Protein involved in regulation of DNA-damage-induced filamentous growth; putative component of DNA replication checkpoint; ortholog of S. cerevisiae Mrc1p, an S-phase checkpoint protein; Hap43p-induced gene
orf19.1010MNT3Candida albicans SC5314Mannosyltransferase; transcription elevated in cyr1, chk1, nik1, and sln1 homozygous null mutants; fungal-specific (no human or murine homolog)
orf19.1011MNN21Candida albicans SC5314Protein of unknown function
orf19.4355Candida albicans SC5314Protein of unknown function
orf19.4356HGT3Candida albicans SC5314Putative glucose transporter of the major facilitator superfamily; the C. albicans glucose transporter family comprises 20 members; 12 probable membrane-spanning segments, extended C terminus; expressed in rich medium with 2% glucose
orf19.4357Candida albicans SC5314Putative protein similar to S. cerevisiae Mgr3p, a subunit of the i-AAA protease supercomplex that degrades misfolded mitochondrial proteins
orf19.661KRR1Candida albicans SC5314Putative nucleolar protein; repressed benomyl treatment or in an azole-resistant strain that overexpresses MDR1; F-12/CO2 early biofilm induced
orf19.3700TOM70Candida albicans SC5314Protein of unknown function
orf19.664Candida albicans SC5314Protein of unknown function
orf19.666Candida albicans SC5314Essential protein required for the DNA integrity checkpoint pathway; Spider biofilm induced
orf19.3705PTC6Candida albicans SC5314Mitochondrial protein phosphatase of the Type 2C-related family (serine/threonine-specific), functional homolog of S. cerevisiae Ptc6p; mutant shows virulence defect
orf19.668TOS4Candida albicans SC5314Putative fork-head transcription factor; rat catheter and Spider biofilm repressed
orf19.4363SGD1Candida albicans SC5314Predicted small ribosomal subunit biogenesis protein; repressed in core stress response; transcript increases in populations of cells exposed to fluconazole over multiple generations; Spider biofilm induced
Locus IdGene NameOrganismDescription
orf19.3707YHB1Candida albicans SC5314Nitric oxide dioxygenase; acts in nitric oxide scavenging/detoxification; role in virulence in mouse; transcript activated by NO, macrophage interaction; Hap43, hypha repressed; mRNA binds She3
orf19.4365Candida albicans SC5314Protein of unknown function
orf19.4366Candida albicans SC5314Protein of unknown function
orf19.4367SMC1Candida albicans SC5314Protein similar to chromosomal ATPases; RNA abundance regulated by tyrosol and cell density; cell-cycle regulated periodic mRNA expression
orf19.4369Candida albicans SC5314Ortholog of S. cerevisiae Spp41; protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3 in S. cerevisiae; mutants are viable
orf19.1027PDR16Candida albicans SC5314Phosphatidylinositol transfer protein; induction correlates with CDR1, CDR2 overexpression/azole resistance; fluphenazine, 17-beta-estradiol, ethynyl estradiol, NO induced; farnesol-downregulated in biofilm; rat catheter biofilm induced
orf19.1029RPP1Candida albicans SC5314Putative ortholog of S. cerevisiae Rpp1; subunit of both RNase MRP and nuclear RNase P; rat catheter and Spider biofilm induced
orf19.670SMT3Candida albicans SC5314SUMO, small ubiquitin-like protein; Smt3p-conjugated proteins localize to septation site and mother side of bud neck; C. albicans septins appear not to be Smt3p-modified, in contrast to S. cerevisiae septins
orf19.6344RBK1Candida albicans SC5314Protein of unknown function
orf19.6345RPG1ACandida albicans SC5314Putative translation initiation factor; mutation confers hypersensitivity to roridin A and verrucarin A; repressed upon phagocytosis by murine macrophage; Spider biofilm repressed
orf19.6347Candida albicans SC5314Pre-mRNA splicing factor; important for catalytic step II of pre-mRNA splicing; possible role in cell cycle progression; Spider biofilm induced
orf19.3004Candida albicans SC5314Protein of unknown function
orf19.6349RVS162Candida albicans SC5314Protein containing a BAR domain, which is found in proteins involved in membrane curvature; null mutant does not display the endocytic, hyphal growth, virulence, or cell wall defects exhibited by mutants in related genes RVS161 and RVS167
orf19.3008COQ4Candida albicans SC5314Protein with a putative role in coenzyme Q biosynthesis; transcriptionally induced by interaction with macrophage; Hap43p-repressed gene
orf19.6350Candida albicans SC5314Protein of unknown function
orf19.6353Candida albicans SC5314Protein of unknown function
orf19.3010Candida albicans SC5314Putative lipoyl ligase; role in modification of mitochondrial enzymes by attachment of lipoic acid groups; rat catheter biofilm induced
orf19.3012ARO80Candida albicans SC5314Zn(II)2Cys6 transcription factor; transcriptional activator of aromatic amino acid catabolism; regulator of aromatic alcohol biosynthesis via the Ehrlich pathway; mutant is viable
orf19.3013CDC12Candida albicans SC5314Septin; essential for viability; forms ring at sites of cell division and also forms filaments in mature chlamydospore; filamentous growth induced; regulated by Nrg1, Tup1, tyrosol and cell density; rat catheter biofilm repressed
orf19.6357Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.3014BMH1Candida albicans SC5314Sole 14-3-3 protein in C. albicans; role in hyphal growth; possibly regulated by host interaction; localizes to yeast-form cell surface, not hyphae; alternatively spliced 5' UTR intron; Spider biofilm repressed
orf19.6358Candida albicans SC5314Protein of unknown function
orf19.3015ARX1Candida albicans SC5314Putative ribosomal large subunit biogenesis protein; repressed in core stress response; repressed by prostaglandins
orf19.6359Candida albicans SC5314Protein of unknown function
orf19.3016Candida albicans SC5314Protein of unknown function
orf19.3018SPP1Candida albicans SC5314Putative histone methyltransferase; induced by nitric oxide independent of Yhb1p; cell-cycle regulated periodic mRNA expression
orf19.5700TLO11Candida albicans SC5314Member of a family of telomere-proximal genes of unknown function; may be spliced in vivo
orf19.6360Candida albicans SC5314Protein involved in pre-mRNA splicing; Spider biofilm induced
orf19.672Candida albicans SC5314Protein of unknown function
orf19.3710YHB5Candida albicans SC5314Flavohemoglobin-related protein; not required for normal NO resistance; predicted globin/FAD-binding/NAD(P)-binding domains but lacks some conserved residues of flavohemoglobins; filament induced; rat catheter and Spider biofilm induced
orf19.3711Candida albicans SC5314Protein with monooxygenase domains; flow model biofilm induced
orf19.3712Candida albicans SC5314Protein of unknown function; induced by Mnl1 under weak acid stress; flow model biofilm induced; Spider biofilm induced
orf19.3713Candida albicans SC5314Protein of unknown function; flow model biofilm induced; Spider biofilm induced; induced by Mnl1 under weak acid stress; transcript detected in high-resolution tiling arrays
orf19.676Candida albicans SC5314Microtubule-binding protein of the cortical microtubule; delays exit from mitosis when the spindle is abnormally oriented; Spider biofilm repressed
orf19.4370Candida albicans SC5314Protein of unknown function; induced by nitric oxide; oxidative stress-induced via Cap1; fungal-specific (no human or murine homolog)
orf19.677CHO1Candida albicans SC5314Putative phosphatidylserine synthase; ortholog of S. cerevisiae CHO1; transposon mutation affects filamentous growth; regulated by Nrg1, Tup1
orf19.3715ASF1Candida albicans SC5314Protein similar to S. cerevisiae Asf1p, a chromatin assembly complex component; likely to be essential for growth, based on an insertional mutagenesis strategy
orf19.4372Candida albicans SC5314Predicted transmembrane transporter; rat catheter and Spider biofilm induced
orf19.679FGR39Candida albicans SC5314Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth
orf19.4373Candida albicans SC5314Protein similar to S. cerevisiae Fmn1p, which is riboflavin kinase; predicted Kex2p substrate; Hap43p-repressed gene
Locus IdGene NameOrganismDescription
orf19.4374PRP42Candida albicans SC5314Putative component of the U1 snRNP, involved in splicing; ortholog of S. cerevisiae PRP42
orf19.1031HMG1Candida albicans SC5314HMG-CoA reductase; enzyme of sterol pathway; inhibited by lovastatin; gene not transcriptionally regulated in response to lovastatin and fluconazole
orf19.4375Candida albicans SC5314Protein of unknown function
orf19.3719Candida albicans SC5314Dubious open reading frame
orf19.1033STR2Candida albicans SC5314Protein of unknown function
orf19.1034Candida albicans SC5314Protein with a predicted cytochrome b5-like Heme/Steroid binding domain; Hap43, caspofungin repressed; flow model biofilm induced
orf19.1035WAR1Candida albicans SC5314Zn(II)2Cys6 transcription factor; plays a role in resistance to weak organic acids; required for yeast cell adherence to silicone substrate; Spider biofilm induced
orf19.1036MNS1Candida albicans SC5314Alpha-1,2-mannosidase; processes Man9GlcNAc2 to Man8GlcNAc2 isomer B; member of ER localized glycosyl hydrolase family 47; ER form is converted by Kex2 to cytosolic form; flow model biofilm repressed
orf19.1037Candida albicans SC5314Protein of unknown function; rat catheter biofilm repressed
orf19.1039BET4Candida albicans SC5314Protein of unknown function
orf19.5704Candida albicans SC5314Protein of unknown function
orf19.6362SPA2Candida albicans SC5314Protein involved in cell polarity, Spitzenkorper formation; required for mouse virulence; localizes to hyphal tip; cell-cycle regulated localization in yeast-form cells; functional domains conserved with S. cerevisiae ; Hap43p-induced gene
orf19.6365PTP1Candida albicans SC5314Phosphotyrosine-specific protein phosphatase; rat catheter biofilm induced
orf19.3022Candida albicans SC5314Protein of unknown function
orf19.3023NGG1Candida albicans SC5314Protein of unknown function
orf19.6367SSB1Candida albicans SC5314HSP70 family heat shock protein; mRNA in yeast and germ tubes; at yeast cell surface, not hyphae; antigenic in human/mouse infection; macrophage, GCN-induced; possibly essential; sumoylation target; Hap43-induced; Spider biofilm repressed
orf19.3026MAS1Candida albicans SC5314Putative mitochondrial processing protease; Hap43-repressed; transcript regulated by Nrg1; oxidative stress-induced via Cap1
orf19.3029EHD3Candida albicans SC5314Predicted 3-hydroxyisobutyryl-CoA hydrolase; mitochondrially localized; Spider biofilm induced
orf19.5711Candida albicans SC5314Putative phosphatidylinositol transfer protein; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.5713YMX6Candida albicans SC5314Putative NADH dehydrogenase; macrophage-downregulated gene; induced by nitric oxide; rat catheter biofilm induced
Locus IdGene NameOrganismDescription
orf19.6371Candida albicans SC5314Protein of unknown function
orf19.6373DCP2Candida albicans SC5314Protein of unknown function
orf19.5717Candida albicans SC5314Protein of unknown function
orf19.6374Candida albicans SC5314Protein of unknown function
orf19.3031SEC62Candida albicans SC5314Putative endoplasmic reticulum (ER) protein-translocation complex subunit
orf19.6375RPS20Candida albicans SC5314Putative ribosomal protein; repressed upon phagocytosis by murine macrophage; transcript positively regulated by Tbf1; Spider biofilm repressed
orf19.6376PTC5Candida albicans SC5314Mitochondrial protein phosphatase of the Type 2C-related family (serine/threonine-specific), involved in drug response and cadmium tolerance
orf19.3034RLI1Candida albicans SC5314Member of RNase L inhibitor (RLI) subfamily of ABC family; predicted not to be a transporter; regulated by Sef1p, Sfu1p, and Hap43p
orf19.6379Candida albicans SC5314Protein of unknown function
orf19.3038TPS2Candida albicans SC5314Trehalose-6-phosphate (Tre6P) phosphatase; mutant heat sensitive, accumulates Tre6P, decreased mouse virulence; possible drug target; 2 conserved phospohydrolase motifs; no mammalian homolog; Hap43-repressed; flow model biofilm induced
orf19.5725Candida albicans SC5314Protein of unknown function
orf19.681HAP43Candida albicans SC5314CCAAT-binding factor-dependent transcription factor; repressor; also called CAP2; required for low iron response; similar to bZIP transcription factor AP-1; repressed by Sfu1; ciclopirox olamine induced; rat catheter, Spider biofilm induced
orf19.683Candida albicans SC5314Predicted ORF from Assemblies 19 and 20; identical to orf19.3391; merged with orf19.3391 in Assembly 20 (see Locus History)
orf19.684Candida albicans SC5314Putative transcription factor with zinc finger DNA-binding motif; heterozygous null mutant exhibits hypersensitivity to parnafungin and cordycepin in the C. albicans fitness test
orf19.685YHM1Candida albicans SC5314Putative mitochondrial carrier protein; fungal-specific (no human or murine homolog); Hap43p-repressed gene
orf19.686Candida albicans SC5314Protein of unknown function; regulated by Nrg1
orf19.687Candida albicans SC5314Protein of unknown function
orf19.688Candida albicans SC5314Mitochondrial ribosomal protein of the small subunit; S. cerevisiae ortholog is essential for viability; Spider biofilm repressed
orf19.3727PHO112Candida albicans SC5314Putative constitutive acid phosphatase; Rim101-repressed; DTT-extractable; N-glycosylated; Hap43-induced; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.4384HXT5Candida albicans SC5314Putative sugar transporter; induced by ciclopirox olamine; Snf3-induced; alkaline repressed; colony morphology-related gene regulation by Ssn6; possibly essential gene
Locus IdGene NameOrganismDescription
orf19.3728Candida albicans SC5314Protein of unknown function
orf19.1042POR1Candida albicans SC5314Mitochondrial outer membrane porin; in detergent-resistant membrane fraction (possible lipid raft component); antigenic in human, mouse; Hap43p-induced; flucytosine-, macrophage-, farnesol- induced; fluconazole, caspofungin repressed
orf19.1043Candida albicans SC5314Protein of unknown function
orf19.1045Candida albicans SC5314Putative U2 snRNP protein; Hap43p-induced gene; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine)
orf19.1048IFD6Candida albicans SC5314Aldo-keto reductase; similar to aryl alcohol dehydrogenases; protein increase correlates with MDR1 overexpression (not CDR1 or CDR2) in fluconazole-resistant clinical isolates; farnesol regulated; possibly essential; Spider biofilm induced
orf19.690PLB2Candida albicans SC5314Putative phospholipase B; conserved catalytic region; 6 putative N-glycosylation motifs; predicted secretion signal; no GPI anchor predicted; fungal-specific (no human or murine homolog)
orf19.691GPD2Candida albicans SC5314Surface protein similar to glycerol 3-P dehydrogenase; binds host Factor H, FHL-1, plasminogen; regulated by Ssn6, Nrg1, Efg1; induced by cell wall regeneration, macrophage/pseudohyphal growth, core stress response; Spider biofilm induced
orf19.3040EHT1Candida albicans SC5314Putative acyl-coenzymeA:ethanol O-acyltransferase; regulated by Sef1, Sfu1, and Hap43; induced by alpha pheromone in SpiderM medium; Spider biofilm induced; promoter bound by Ndt80
orf19.3041Candida albicans SC5314Protein of unknown function
orf19.6385ACO1Candida albicans SC5314Aconitase; induced in high iron; 2 upstream CCAAT motifs; amino acid starvation (3-AT), amphotericin B, phagocytosis, farnesol induced; Hap43, fluconazole-repressed; Gcn4-regulated; antigenic in infection; flow and Spider biofilm repressed
orf19.6387HSP104Candida albicans SC5314Heat-shock protein; roles in biofilm and virulence; complements chaperone, prion activity in S. cerevisiae; guanidine-insensitive; heat shock/stress induced; repressed in farnesol-treated biofilm; sumoylation target; Spider biofilm induced
orf19.3048Candida albicans SC5314Protein of unknown function; repressed by alpha pheromone in SpiderM medium
orf19.5730Candida albicans SC5314Putative phenylacrylic acid decarboxylase; clade-associated gene expression
orf19.5731PAD1Candida albicans SC5314Putative phenylacrylic acid decarboxylase; repressed by Rgt1p
orf19.5734POP2Candida albicans SC5314Component of the Ccr4-Pop2 mRNA deadenylase; heterozygous null mutant exhibits resistance to parnafungin and cordycepin in the C. albicans fitness test
orf19.5735CDC50Candida albicans SC5314Putative endosomal protein; induced by Mnl1p under weak acid stress
orf19.6392Candida albicans SC5314Protein of unknown function
orf19.5736ALS5Candida albicans SC5314ALS family adhesin; highly variable; expression in S. cerevisiae causes adhesion to human epithelium, endothelium or ECM, endothelial invasiveness by endocytosis and, at high abundance, ECM-induced aggregation; can form amyloid fibrils
orf19.6393Candida albicans SC5314Putative Arf3p GTPase activating protein; Hap43p-repressed gene; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.3050AGE1Candida albicans SC5314Putative GTPase activator; induced in low iron; rat catheter biofilm repressed
Locus IdGene NameOrganismDescription
orf19.3052YPT1Candida albicans SC5314Functional homolog of S. cerevisiae Ypt1p, which is an essential small Ras-type GTPase involved in protein secretion at ER-to-Golgi; dominant-negative mutation causes SAP secretion defect and accumulation of intracellular secretory vesicles
orf19.6396Candida albicans SC5314Putative patatin-like phospholipase; similar to S. cerevisiae Nte1p, which is predicted to be a membrane protein; antigenic during human oral infection; Hap43p-repressed gene
orf19.3053Candida albicans SC5314Protein of unknown function; present in exponential and stationary phase yeast; identified in extracts from biofilm and planktonic cells; flow model biofilm induced gene; GlcNAc-induced protein
orf19.3054RPN3Candida albicans SC5314Putative non-ATPase regulatory subunit of the 26S proteasome lid; amphotericin B repressed; oxidative stress-induced via Cap1p
orf19.3055MED17Candida albicans SC5314Putative RNA polymerase II mediator complex subunit; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.3730Candida albicans SC5314Protein similar to S. cerevisiae Kre27p, which has a role in resistance to killer toxin; predicted Kex2p substrate
orf19.693Candida albicans SC5314Protein of unknown function; Spider biofilm induced; rat catheter biofilm repressed
orf19.695RGS2Candida albicans SC5314Protein of RGS superfamily; mutants are viable; rat catheter and Spider biofilm induced
orf19.696STE2Candida albicans SC5314Receptor for alpha factor mating pheromone, MFalpha; required for a-type cells to respond to alpha factor, for opaque a-form mating and white a-form response; possible Kex2p substrate; a-specific, alpha-factor induced, A1p-Alpha2p repressed
orf19.4390Candida albicans SC5314Protein of unknown function; repressed by alpha pheromone in SpiderM medium; transcript induced by Mnl1 under weak acid stress
orf19.697Candida albicans SC5314Protein of unknown function
orf19.3735Candida albicans SC5314Protein of unknown function; induced by alpha pheromone in SpiderM medium
orf19.698Candida albicans SC5314Integral ER membrane protein; predicted role in maintenance of ER zinc homeostasis; Spider biofilm induced
orf19.3736KAR4Candida albicans SC5314Transcription factor; required for gene regulation in response to pheromones; ortholog of S. cerevisiae Kar4; role in karyogamy; opaque-specific, a-specific; induced by alpha factor
orf19.4393CIT1Candida albicans SC5314Citrate synthase; induced by phagocytosis; induced in high iron; Hog1-repressed; Efg1-regulated under yeast, not hyphal growth conditions; present in exponential and stationary phase; Spider biofilm repressed; rat catheter biofilm induced
orf19.1050Candida albicans SC5314Protein of unknown function
orf19.4394Candida albicans SC5314Protein of unknown function; induced by alpha pheromone in SpiderM medium
orf19.1051HTA2Candida albicans SC5314Putative histone H2A; farnesol regulated; rat catheter biofilm repressed; Spider biofilm repressed; Hap43-induced
orf19.1052Candida albicans SC5314Predicted histone H2B; Hap43-induced gene; Spider biofilm repressed
orf19.4396Candida albicans SC5314Mitochondrial inner membrane protein; mammalian mitofilin domain; Spider biofilm repressed
Locus IdGene NameOrganismDescription
orf19.4398Candida albicans SC5314Protein of unknown function; rat catheter biofilm induced
orf19.1055CDC3Candida albicans SC5314Septin; essential for viability; functional homolog of S. cerevisiae Cdc3p; down-regulation associated with azole resistance; macrophage/pseudohyphal-repressed; virulence-group-correlated expression; gene has intron
orf19.4399NCS2Candida albicans SC5314Putative cytosolic thiouridylase subunit; Spider biofilm induced
orf19.1059HHF1Candida albicans SC5314Putative histone H4; repressed in fkh2 mutant; regulated by Efg1; fluconazole induced; amphotericin B repressed; farnesol regulated; colony morphology-related gene regulation by Ssn6; Hap43-induced; rat catheter and Spider biofilm repressed
orf19.3057Candida albicans SC5314Protein of unknown function
orf19.3059SUA71Candida albicans SC5314Transcription factor TFIIB; required for transcription initiation and start site selection by RNA polymerase II; downregulated during planktonic growth, whereas related SUA72 is induced; induced by Tbf1; rat catheter, Spider biofilm induced
orf19.5741ALS1Candida albicans SC5314Cell-surface adhesin; adhesion, virulence, immunoprotective roles; band at hyphal base; Rfg1, Ssk1, Spider biofilm induced; flow model biofilm repressed; CAI-4 strain background effects; promoter bound Bcr1, Tec1, Efg1, Ndt80, and Brg1
orf19.2400Candida albicans SC5314Protein of unknown function
orf19.2401Candida albicans SC5314Protein of unknown function
orf19.5746ALA1Candida albicans SC5314Alanyl-tRNA synthetase; translational regulation generates cytoplasmic and mitochondrial forms; Gcn4p-regulated; repressed by amino acid starvation (3-AT); translation-related genes downregulated upon phagocytosis by murine macrophages
orf19.3060Candida albicans SC5314OPutative dolichyl-diphosphooligosaccharide-protein glycotransferase; role in protein N-linked glycosylation; Spider biofilm repressed
orf19.2404Candida albicans SC5314Protein of unknown function
orf19.3062Candida albicans SC5314Protein of unknown function
orf19.3063HFL1Candida albicans SC5314HAP5-like; ortholog of S. cerevisiae Dpb3; third-largest subunit of DNA polymerase II (DNA polymerase epsilon); phosphorylated protein; mutants have a growth defect
orf19.2407DPS1-1Candida albicans SC5314Putative tRNA-Asp synthetase; genes encoding ribosomal subunits, translation factors, tRNA synthetases are downregulated upon phagocytosis by murine macrophage; protein enriched in stationary phase yeast cultures
orf19.2408Candida albicans SC5314Protein of unknown function
orf19.3066ENG1Candida albicans SC5314Endo-1,3-beta-glucanase; ortholog of S. cerevisiae Dse4 needed for cell separation; caspofungin, fluconazole repressed; repressed by alpha pheromone in SpiderM medium; flow model biofilm induced; rat catheter biofilm repressed
orf19.5751ORM1Candida albicans SC5314Putative endoplasmic reticulum membrane protein; Hap43p-repressed gene; mutation confers hypersensitivity to aureobasidin A
orf19.5753HGT10Candida albicans SC5314Glycerol permease involved in glycerol uptake; member of the major facilitator superfamily; induced by osmotic stress, at low glucose in rich media, during cell wall regeneration; 12 membrane spans; Hap43p-induced gene
orf19.2410SYS3Candida albicans SC5314Protein similar to S. cerevisiae Sys3p; putative role in endosome-Golgi vesicle docking; upregulated in biofilm; induced upon adherence to polystyrene
Locus IdGene NameOrganismDescription
orf19.2412Candida albicans SC5314Protein of unknown function
orf19.2414Candida albicans SC5314Ortholog of S. cerevisiae Mpm1; a mitochondrial intermembrane space protein of unknown function; Hap43-repressed; Spider biofilm induced
orf19.3071MIH1Candida albicans SC5314Putative protein phosphatase of the PTP family (tyrosine-specific); ortholog of S. cerevisiae Mih1; mRNA binds She3
orf19.2415Candida albicans SC5314Protein of unknown function
orf19.3740PGA23Candida albicans SC5314Putative GPI-anchored protein of unknown function; Rim101-repressed; Cyr1-regulated; colony morphology-related gene regulation by Ssn6
orf19.3743Candida albicans SC5314Protein of unknown function
orf19.3746OPT2Candida albicans SC5314Oligopeptide transporter; induced upon phagocytosis by macrophage; macrophage/pseudohyphal-repressed after 16h; fluconazole-induced; virulence-group-correlated expression; Hap43-repressed
orf19.1061HHT21Candida albicans SC5314Putative histone H3; amphotericin B repressed; regulated by Efg1, farnesol; Hap43-induced; rat catheter and Spider biofilm repressed
orf19.1063Candida albicans SC5314Protein of unknown function
orf19.1064ACS2Candida albicans SC5314Acetyl-CoA synthetase; antigenic during human and murine infection; induced by Efg1; macrophage-induced protein; soluble protein in hyphae; gene contains intron; flow model and Spider biofilm repressed
orf19.1066GIG1Candida albicans SC5314Protein induced by N-acetylglucosamine (GlcNAc); localized in cytoplasm; mutation causes increased resistance to nikkomycin Z
orf19.1069RPN4Candida albicans SC5314C2H2 transcription factor; putative regulator of proteasome genes; DNA recognition sequence (GAAGGCAAAA) enriched in regions upstream of proteasome genes; induced in core stress response; Hap43-induced; Spider biofilm induced
orf19.3752RAD51Candida albicans SC5314Protein involved in homologous recombination and DNA repair; flucytosine induced; slow growth and increased white-to-opaque switching frequency in null mutant
orf19.3755Candida albicans SC5314Protein of unknown function
orf19.3757ATP20Candida albicans SC5314Putative mitochondrial ATP synthase; shows colony morphology-related gene regulation by Ssn6p; flucytosine induced; caspofungin repressed; macrophage/pseudohyphal-induced
orf19.3758Candida albicans SC5314Protein of unknown function
orf19.1077ATM1Candida albicans SC5314Member of MDR subfamily of ABC family; ortholog of S. cerevisiae ABC transporter, Atm1; induced in low iron; induced by nitric oxide independent of Yhb1
orf19.6304LYS5Candida albicans SC5314Phosphopantetheinyl transferase; enzyme of lysine biosynthesis; modifies, and thereby activates, Lys2p alpha-aminoadipate reductase; functional homolog of S. cerevisiae Lys5p
orf19.6306Candida albicans SC5314Trimethylaminobutyraldehyde dehydrogenase, the third enzyme of the carnitine biosynthesis pathway
orf19.6307Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.6309MSS11Candida albicans SC5314Transcription factor; activator that binds to Flo8 via a LisH motif to cooperatively activate transcription of hypha-specific genes; required for hyphal growth
orf19.3761CDC54Candida albicans SC5314Putative pre-replication complex helicase subunit; transcript regulated by Nrg1 and Mig1; periodic mRNA expression, peak at cell-cycle M/G1 phase; Hap43-induced
orf19.3762Candida albicans SC5314Protein of unknown function
orf19.3764GSG1Candida albicans SC5314Putative subunit of the TRAPP complex; involved in targeting of ER-to-Golgi transport vesicles; flow model biofilm induced
orf19.3767PEP1Candida albicans SC5314Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between late-Golgi and prevacuolar endosome-like compartments; rat catheter biofilm repressed
orf19.3073Candida albicans SC5314Protein of unknown function
orf19.2418Candida albicans SC5314Protein of unknown function
orf19.3076Candida albicans SC5314Protein of unknown function
orf19.3077VID21Candida albicans SC5314Subunit of the NuA4 histone acetyltransferase complex; soluble protein in hyphae; Spider biofilm repressed
orf19.5760IHD1Candida albicans SC5314GPI-anchored protein; alkaline, hypha-induced; regulated by Nrg1, Rfg1, Tup1 and Tsa1, Tsa1B in minimal media at 37; oralpharyngeal candidasis induced ; Spider biofilm induced; regulated in Spider biofilms by Tec1, Efg1, Ndt80, Rob1, Brg1
orf19.5763Candida albicans SC5314Protein of unknown function
orf19.5764SKI8Candida albicans SC5314Protein of unknown function
orf19.5767Candida albicans SC5314Protein of unknown function
orf19.3080Candida albicans SC5314Protein of unknown function
orf19.2425HGT18Candida albicans SC5314Putative glucose transporter of the major facilitator superfamily; the C. albicans glucose transporter family comprises 20 members; 12 probable membrane-spanning segments; expressed in rich medium with 2% glucose
orf19.3083Candida albicans SC5314Putative lipid phosphatase of the endoplasmic reticulum; role in DNA repair, actin cytoskeleton organization, cellular manganese ion homeostasis; Spider biofilm repressed
orf19.3084Candida albicans SC5314Protein of unknown function
orf19.2429Candida albicans SC5314Protein of unknown function; induced by alpha pheromone in SpiderM medium
orf19.3086SEC10Candida albicans SC5314Protein of unknown function
orf19.3087UBI3Candida albicans SC5314Fusion of ubiquitin with the S34 protein of the small ribosomal subunit; mRNA decreases upon heat shock, appears to be degraded; functional homolog of S. cerevisiae RPS31; Hap43-induced; Spider biofilm repressed
Locus IdGene NameOrganismDescription
orf19.3089Candida albicans SC5314Predicted mitochondrial intermembrane space protein; predicted role in phospholipid metabolism; rat catheter and Spider biofilm induced
orf19.5770OPT8Candida albicans SC5314Oligopeptide transporter; similar to Opt1 and to S. cerevisiae Ygl114wp, but not other OPTs; induced by nitric oxide, amphotericin B; expression of OPT6, 7, 8 does not complement mutants lacking Opt1, Opt2, and Opt3; Spider biofilm induced
orf19.5771PBP2Candida albicans SC5314Putative RNA binding protein; transcript regulated by Nrg1, Mig1, and Tup1
orf19.5772Candida albicans SC5314Protein of unknown function
orf19.2430Candida albicans SC5314Protein of unknown function
orf19.5775Candida albicans SC5314Predicted ORF overlapping the Major Repeat Sequence on chromosome 6; member of a family encoded by FGR6-related genes in the RB2 repeat sequence; rat catheter biofilm repressed
orf19.3769Candida albicans SC5314Protein of unknown function
orf19.1083Candida albicans SC5314Putative protein of unknown function; macrophage-induced gene
orf19.1084CDC39Candida albicans SC5314Protein similar to S. cerevisiae Cdc39p, which is part of the CCR4-NOT transcription regulatory complex; transposon mutation affects filamentous growth
orf19.1086Candida albicans SC5314Protein of unknown function
orf19.1089PEX11Candida albicans SC5314Putative peroxisomal membrane protein; role in fatty acid oxidation; expression is Tac1-regulated; Hms1p-dependent induction by geldamycin; Spider biofilm induced
orf19.6312RPS3Candida albicans SC5314Ribosomal protein S3; Hog1, Hap43-induced; grepressed upon phagocytosis by murine macrophage; present in exponential and stationary phase cells; Spider biofilm repressed
orf19.6314RPB8Candida albicans SC5314Putative subunit of RNA polymerases I, II, and III; regulated by Gcn4p; repressed in response to amino acid starvation (3-aminotriazole treatment); heterozygous null mutant exhibits resistance to parnafungin
orf19.6315Candida albicans SC5314Protein of unknown function
orf19.6317ADE6Candida albicans SC53145-Phosphoribosylformyl glycinamidine synthetase; adenine biosynthesis; not induced in GCN response, in contrast to S. cerevisiae Ade6; protein in stationary phase yeast-form cultures; flow model and rat catheter biofilm repressed
orf19.6318Candida albicans SC5314Protein of unknown function
orf19.3770ARG8Candida albicans SC5314Putative acetylornithine aminotransferase; Gcn2, Gcn4 regulated; rat catheter biofilm induced; Spider biofilm induced
orf19.3773CDL1Candida albicans SC5314Putative RNAse III, ortholog of S. cerevisiae RNT1; merged with orf19.3772 in Assembly 21
orf19.3774PPG1Candida albicans SC5314Putative protein phosphatase of the Type 2A-related family (serine/threonine-specific), similar to S. cerevisiae Ppg1p; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.3775SSK2Candida albicans SC5314MAP kinase kinase kinase (MAPKKK); regulates Hog1 activation and signaling; repressed by ciclopirox olamine
Locus IdGene NameOrganismDescription
orf19.3777IMG2Candida albicans SC5314Mitochondrial ribosomal protein of the large subunit; rat catheter biofilm induced
orf19.3778Candida albicans SC5314Protein with a predicted role in ribosome biogenesis; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU); repressed in core stress response; repressed by prostaglandins; Hap43-induced
orf19.1092Candida albicans SC5314Dolichol-P-Man dependent alpha(1-3) mannosyltransferase; role in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins; rat catheter biofilm repressed
orf19.1093FLO8Candida albicans SC5314Transcription factor; required for hyphal formation and CO2 induced white-opaque switching; regulates hyphal gene expression; required for virulence in mouse systemic infection; binds Efg1p; binds Mss11p via LisH motif; has LUFS domain
orf19.7569SIK1Candida albicans SC5314Putative U3 snoRNP protein; Hap43p-induced gene; physically interacts with TAP-tagged Nop1p
orf19.4228Candida albicans SC5314Protein with a role in insertion of tail-anchored proteins into the ER membrane; Spider biofilm repressed
orf19.1680TFP1Candida albicans SC5314Subunit of vacuolar H+-ATPase; stationary phase enriched protein; sumoylation target; Spider biofilm repressed
orf19.1682Candida albicans SC5314Membrane protein; Hap43p-repressed gene; repressed by nitric oxide
orf19.1684Candida albicans SC5314Protein of unknown function
orf19.1685ZCF7Candida albicans SC5314Predicted Zn(II)2Cys6 transcription factor; mutant shows reduced colony wrinkling on Spider medium and is unable to utilize mannitol as a carbon source; mutants have increased colonization of mouse kidneys
orf19.6911Candida albicans SC5314Protein of unknown function
orf19.532RBR2Candida albicans SC5314Cell wall protein; expression repressed by Rim101; transcript regulated upon white-opaque switching; repressed by alpha pheromone in SpiderM medium; macrophage-induced gene
orf19.6912Candida albicans SC5314Putative ethanolamine kinase
orf19.533Candida albicans SC5314Protein of unknown function
orf19.6913GCN2Candida albicans SC5314Translation initiation factor 2-alpha (eIF2alpha) kinase; has nonessential role in amino acid starvation response, in contrast to S. cerevisiae homolog; similar to S. cerevisiae Gcn2p
orf19.7570UGA3Candida albicans SC5314Zn(II)2Cys6 transcription factor; required for utilization of gamma-aminobutyrate (GABA) as a nitrogen source; mutants display decreased CFU in mouse kidneys; Spider biofilm induced
orf19.535RBR1Candida albicans SC5314Glycosylphosphatidylinositol (GPI)-anchored cell wall protein; required for filamentous growth at acidic pH; expression repressed by Rim101 and activated by Nrg1; Hap43-induced
orf19.7571UBC4Candida albicans SC5314Protein of unknown function
orf19.6915MRE11Candida albicans SC5314Putative DNA double-strand break repair factor; involved in response to oxidative stress and drug resistance
orf19.536Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.7572SPT7Candida albicans SC5314Putative SAGA transcriptional regulatory complex subunit; mutation confers hypersensitivity to toxic ergosterol analog, and to amphotericin B
orf19.6916Candida albicans SC5314Protein of unknown function
orf19.537Candida albicans SC5314Protein of unknown function
orf19.4230Candida albicans SC531420S proteasome subunit (beta7); protein present in exponential and stationary growth phase yeast cultures
orf19.538GPI2Candida albicans SC5314Subunit of the GPI-N-acetylglucosaminyl transferase (GPI-GnT) that catalyzes the first step in GPI anchor biosynthesis
orf19.3649Candida albicans SC5314Protein of unknown function
orf19.6991PRE3Candida albicans SC5314Putative beta-1 proteasome subunit; macrophage-induced protein; regulated by Gcn2p and Gcn4p; GlcNAc-induced protein
orf19.6992QDR2Candida albicans SC5314Predicted MFS membrane transporter, member of the drug:proton antiporter (12 spanner) (DHA1) family; Spider biofilm induced
orf19.6993GAP2Candida albicans SC5314General amino acid permease; ketoconazole, flucytosine repressed; Ssy1-dependent histidine induction; regulated by Nrg1, Tup1; colony morphology-related gene regulation by Ssn6; Spider and flow model biofilm induced
orf19.3651PGK1Candida albicans SC5314Phosphoglycerate kinase; localizes to cell wall and cytoplasm; antigenic in murine/human infection; flow model biofilm, Hog1-, Hap43-, GCN-induced; repressed upon phagocytosis; repressed in Spider biofilms by Bcr1, Ndt80, Rob1, Brg1
orf19.6995ATO6Candida albicans SC5314Putative fungal-specific transmembrane protein
orf19.3653FAT1Candida albicans SC5314Predicted enzyme of sphingolipid biosynthesis; upregulated in biofilm
orf19.6997ATO5Candida albicans SC5314Putative fungal-specific transmembrane protein
orf19.3655Candida albicans SC5314Protein of unknown function
orf19.6999Candida albicans SC5314Predicted oxidoreductase; rat catheter biofilm repressed
orf19.3658Candida albicans SC5314Protein of unknown function
orf19.6200Candida albicans SC5314Pry family pathogenesis-related protein; oral infection upregulated gene; mutant has reduced capacity to damage oral epithelial cells
orf19.6203PUT3Candida albicans SC5314Zn(II)2Cys6 transcription factor; has similarity to S. cerevisiae Put3, a transcription factor involved in the regulation of proline utilization genes
orf19.6205Candida albicans SC5314Protein of unknown function
orf19.3661Candida albicans SC5314Putative deubiquitinating enzyme; induced by Mnl1 under weak acid stress
Locus IdGene NameOrganismDescription
orf19.3663PHO91Candida albicans SC5314Putative low-affinity phosphate transporter; fungal-specific (no human or murine homolog)
orf19.3665SET6Candida albicans SC5314Ortholog of S. cerevisiae Set6, a SET domain protein of unknown function; Hap43-induced; rat catheter and Spider biofilm induced
orf19.3667Candida albicans SC5314Protein of unknown function
orf19.3668HGT2Candida albicans SC5314Putative MFS glucose transporter; 20 member C. albicans glucose transporter family; 12 probable membrane-spanning segments; expressed in rich medium with 2% glucose; rat catheter and Spider biofilm induced
orf19.6211Candida albicans SC5314Protein of unknown function; protein newly produced during adaptation to the serum
orf19.6214ATC1Candida albicans SC5314Cell wall acid trehalase; catalyzes hydrolysis of the disaccharide trehalose; similar to S. cerevisiae vacuolar acid trehalase (Ath1p); Hap43p-repressed gene
orf19.6217PGA63Candida albicans SC5314Component COPII vesicle coat; required for vesicle formation in ER to Golgi transport; predicted GPI-anchor; flow model and Spider biofilm repressed
orf19.7574Candida albicans SC5314Protein of unknown function
orf19.6918Candida albicans SC5314Protein of unknown function; Hap43-induced gene; Spider biofilm induced
orf19.4231PTH2Candida albicans SC5314Putative cAMP-independent regulatory protein; constitutive expression independent of MTL or white-opaque status; Spider biofilm induced
orf19.6919Candida albicans SC5314Protein of unknown function
orf19.539LAP3Candida albicans SC5314Putative aminopeptidase; positively regulated by Sfu1; clade-associated gene expression; virulence-group-correlated expression; induced by alpha pheromone in SpiderM medium; Hap43-induced; Spider and flow model biofilm induced
orf19.7576Candida albicans SC5314Ortholog of S. pombe atl1 alkyltransferase-like protein; mutants are viable; Spider biofilm induced
orf19.7577MSS51Candida albicans SC5314Putative mRNA maturation factor; fungal-specific (no human or murine homolog)
orf19.4235PDE1Candida albicans SC5314Low affinity cyclic nucleotide phosphodiesterase; mediates cAMP signaling in response to glucose or intracellular acidification; macrophage-repressed; Spider biofilm induced
orf19.7579FGR34Candida albicans SC5314Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth
orf19.1691Candida albicans SC5314Plasma-membrane-localized protein; filament induced; Hog1, ketoconazole, fluconazole and hypoxia-induced; regulated by Nrg1, Tup1, Upc2; induced by prostaglandins; flow model biofilm induced; rat catheter and Spider biofilm repressed
orf19.1697Candida albicans SC5314Protein of unknown function
orf19.1698Candida albicans SC5314Protein of unknown function
orf19.540Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.541Candida albicans SC5314Protein of unknown function
orf19.6921Candida albicans SC5314Protein of unknown function
orf19.6923Candida albicans SC5314Protein of unknown function
orf19.544RPR2Candida albicans SC5314Protein of unknown function
orf19.7580Candida albicans SC5314Protein of unknown function
orf19.6924HTA1Candida albicans SC5314Histone H2A; repressed in fkh2 mutant; amphotericin B repressed; farnesol regulated; RNA abundance regulated by tyrosol and cell density; Hap43-induced gene; Spider biofilm repressed
orf19.6925HTB1Candida albicans SC5314Histone H2B; induced by adherence to polystyrene; amphotericin B, caspofungin repressed; flucytosine, fluconazole induced; Efg1 regulated; slow growth, increased white-to opaque switch in ectopic expression strains; Spider biofilm repressed
orf19.547Candida albicans SC5314Protein of unknown function
orf19.3672GAL10Candida albicans SC5314UDP-glucose 4-epimerase; galactose utilization; mutant has cell wall defects and increased filamentation; GlcNAc-, fluconazole- and ketoconazole-induced; stationary phase enriched protein; rat catheter and flow model biofilm induced
orf19.3673Candida albicans SC5314Protein of unknown function
orf19.3675GAL7Candida albicans SC5314Putative galactose-1-phoshphate uridyl transferase; downregulated by hypoxia, upregulated by ketoconazole; macrophage/pseudohyphal-repressed
orf19.3677Candida albicans SC5314Protein of unknown function
orf19.3678Candida albicans SC5314Protein of unknown function
orf19.6220Candida albicans SC5314Protein of unknown function
orf19.6224Candida albicans SC5314RTA domain protein; predicted role in response to stress; Spider biofilm induced
orf19.6227Candida albicans SC5314Protein of unknown function
orf19.3680SEP7Candida albicans SC5314Septin, required for wild-type invasive growth in vitro but not required for virulence in a mouse model of systemic infection; localizes to hyphal septum or bud neck; Asn-rich; aberrant gel mobility; phosphorylated in vitro by Gin4p
orf19.3683AGE3Candida albicans SC5314Putative ADP-ribosylation factor GTPase activating protein, functional ortholog of S. cerevisiae GCS1; mutation affects endocytosis, hyphal growth, chemical and drug resistance, and sensitivity to cell wall inhibitors
orf19.3685PSY2Candida albicans SC5314Putative protein phosphatase PP4 complex subunit; macrophage-induced gene
orf19.3686Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.6230Candida albicans SC5314Protein of unknown function
orf19.6231MRPL19Candida albicans SC5314Putative ribosomal protein; induced upon adherence to polystyrene; Spider biofilm repressed
orf19.6232NPR1Candida albicans SC5314Predicted serine/threonine protein kinase, involved in regulation of ammonium transport; induced in core stress response; Hap43p-repressed gene
orf19.6235Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.6236NOP6Candida albicans SC5314Putative ortholog of S. cerevisiae Nop6; role in ribosomal small subunit biogenesis; Spider biofilm induced
orf19.6237RAC1Candida albicans SC5314G-protein of RAC subfamily; required for embedded filamentous growth, not for serum-induced hyphal growth; dynamic localization at plasma membrane and nucleus; similar to, but not interchangeable with, Cdc42p; lacks S. cerevisiae homolog
orf19.6238Candida albicans SC5314Protein of unknown function
orf19.6239Candida albicans SC5314Putative serine/threonine protein kinase; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.3693PGA5Candida albicans SC5314Putative GPI-anchored beta-1,3-glucanosyltransferase with similarity to the A. fumigatus GEL family; fungal-specific (no human or murine homolog)
orf19.3694Candida albicans SC5314Protein of unknown function
orf19.7583ZCF39Candida albicans SC5314Zn(II)2Cys6 transcription factor; mutants are viable; filament induced; required for yeast cell adherence to silicone substrate; Spider biofilm induced
orf19.4240Candida albicans SC5314Protein of unknown function
orf19.548CDC10Candida albicans SC5314Septin, required for wild-type cell, hyphal, or chlamydospore morphology; role in virulence and kidney tissue invasion in mouse infection; forms ring at sites of cell division and filaments in mature chlamydospore; Spider biofilm repressed
orf19.7585INO1Candida albicans SC5314Inositol-1-phosphate synthase; antigenic in human; repressed by farnesol in biofilm or by caspofungin; upstream inositol/choline regulatory element; glycosylation predicted; rat catheter, flow model induced; Spider biofilm repressed
orf19.4242CST20Candida albicans SC5314Protein kinase of Ste20p/p65PAK family, required for wild-type mating efficiency and virulence in a mouse model; Cst20p-Hst7p-Cek1p-Cph1p MAPK pathway regulates some hyphal growth; involved in Cdc42p growth regulation
orf19.7586CHT3Candida albicans SC5314Major chitinase; secreted; functional homolog of S. cerevisiae Cts1p; 4 N-glycosylation motifs; possible O-mannosylation; putative signal peptide; hyphal-repressed; farnesol upregulated in biofilm; regulated by Efg1p, Cyr1p, Ras1p
orf19.4243Candida albicans SC5314Protein of unknown function
orf19.7588Candida albicans SC5314Protein of unknown function
orf19.4245Candida albicans SC5314Protein with a predicted pleckstrin domain; Hap43-repressed gene
orf19.4247Candida albicans SC5314Protein of unknown function; rat catheter and Spider biofilm repressed
Locus IdGene NameOrganismDescription
orf19.550PDX3Candida albicans SC5314Pyridoxamine-phosphate oxidase; transcript regulated by yeast-hypha switch and by Nrg1, Mig1, Tup1; Hap43, caspofungin repressed; present in exponential and stationary phase yeast cultures
orf19.6930SOL1Candida albicans SC5314Cell cycle regulator; partial functional homolog of S. cerevisiae Sic1p; protein degradation regulated by SCF(CDC4) pathway; CDK phosphorylation predicted
orf19.6931Candida albicans SC5314Putative cleavage factor I subunit; heterozygous null mutant exhibits hypersensitivity to parnafungin and cordycepin in the C. albicans fitness test
orf19.554DIT2Candida albicans SC5314Monooxygenase of the cytochrome P450 family; produces N,N'-bisformyl dityrosine from N-formyltyrosine; regulated by Nrg1, Mig1, and Tup1; role in chlamydospore formation; Spider biofilm induced
orf19.555Candida albicans SC5314Protein similar to S. cerevisiae Cis3p, which has a role cell-wall-related processes; predicted Kex2p substrate; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.7592FAA4Candida albicans SC5314Predicted acyl CoA synthase
orf19.6936RAD53Candida albicans SC5314Protein involved in regulation of DNA-damage-induced filamentous growth; putative component of cell cycle checkpoint; ortholog of S. cerevisiae Rad53p, protein kinase required for cell-cycle arrest in response to DNA damage
orf19.7593Candida albicans SC5314Putative asparaginase; predicted role in asparagine catabolism; Spider biofilm induced
orf19.4250Candida albicans SC5314Protein of unknown function
orf19.557Candida albicans SC5314Protein of unknown function; Hap43-repressed; Spider biofilm repressed
orf19.7594Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.6938MEU1Candida albicans SC5314Putative methylthioadenosine phosphorylase; protein level decreases in stationary phase cultures
orf19.3695Candida albicans SC5314Protein of unknown function
orf19.3697Candida albicans SC5314Protein of unknown function
orf19.3698Candida albicans SC5314Protein of unknown function that may function in RNA processing; filament induced
orf19.6240Candida albicans SC5314SH3-domain protein; role in barrier septum assembly involved in cell cycle cytokinesis; activates the Chs2 chitin synthase activity during cytokinesis; Spider biofilm repressed
orf19.6243VPS34Candida albicans SC5314Autophosphorylated class III phosphatidylinositol 3-kinase; required for normal vesicle transport, hyphal growth, fibroblast adherence, virulence in mouse systemic infection; growth-regulated; caspofungin and hydrogen peroxide sensitivity
orf19.6245Candida albicans SC5314Protein of unknown function; regulated by osmotic stress via Hog1 and oxidative stress (Hog1- and Cap1-independent); induced by alpha pheromone in SpiderM medium; Spider biofilm induced
orf19.6247Candida albicans SC5314Protein of unknown function
orf19.6249HAK1Candida albicans SC5314Putative potassium transporter; similar to Schwanniomyces occidentalis Hak1p; amphotericin B induced; induced upon phagocytosis by macrophage; Hap43-repressed; rat catheter biofilm repressed
Locus IdGene NameOrganismDescription
orf19.10ALK8Candida albicans SC5314Alkane-inducible cytochrome P450; catalyzes hydroxylation of lauric acid to hydroxylauric acid; overproduction causes fluconazole resistance in WT and causes multidrug resistance in a cdr1 cdr2 double mutant; rat catheter biofilm repressed
orf19.17SCP1Candida albicans SC5314Putative cortical actin cytoskeleton protein; constitutive expression independent of MTL or white-opaque status
orf19.6252Candida albicans SC5314Protein of unknown function
orf19.6253RPS23ACandida albicans SC5314Putative ribosomal protein; repressed upon phagocytosis by murine macrophage; Spider biofilm repressed
orf19.6255Candida albicans SC5314Putative protein of unknown function; Hap43p-repressed gene
orf19.6259Candida albicans SC5314Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in the nucleus and cytoplasm; Spider biofilm induced
orf19.24RTA2Candida albicans SC5314Flippase; sphingolipid long chain base release; mediates calcineurin-dependent resistance to azoles; stress-associate; Plc1, Ca2+, calcineurin-regulated; ketoconazole, caspofungin induced; Spider biofilm induced; flow biofilm repressed
orf19.25Candida albicans SC5314Protein of unknown function
orf19.29Candida albicans SC5314Ortholog of S. cerevisiae Tah11, a DNA replication licensing factor required for pre-replication complex assembly; rat catheter, flow model and Spider biofilm induced
orf19.5601Candida albicans SC5314Protein of unknown function
orf19.5602BMT6Candida albicans SC5314Beta-mannosyltransferase; beta-1,2-mannosylation of phospholipomannan; member of a 9-member family including Bmt1, Bmt2, Bmt3, and Bmt4 with roles in mannosylation of cell wall phosphopeptidomannan; flow model biofilm induced
orf19.4251ZCF22Candida albicans SC5314Predicted Zn(II)2Cys6 transcription factor
orf19.559FGR14Candida albicans SC5314Protein encoded in retrotransposon Zorro3 with similarity to retroviral endonuclease-reverse transcriptase proteins; lacks an ortholog in S. cerevisiae; transposon mutation affects filamentous growth
orf19.7596Candida albicans SC5314Protein with a phosphoglycerate mutase family domain; Hap43-repressed gene
orf19.4253Candida albicans SC5314Protein of unknown function
orf19.7598Candida albicans SC5314Protein of unknown function
orf19.4255ECM331Candida albicans SC5314GPI-anchored protein; mainly at plasma membrane, also at cell wall; Hap43, caspofungin-induced; Plc1-regulated; Hog1, Rim101-repressed; colony morphology-related regulated by Ssn6; induced by ketoconazole and hypoxia
orf19.4257INT1Candida albicans SC5314Protein structurally similar to alpha-subunit of human leukocyte integrin; role in morphogenesis, adhesion, and mouse cecal colonization and systemic virulence; similar to S. cerevisiae Bud4; Hap43-induced gene
orf19.6941Candida albicans SC5314Putative diacylglycerol acyltransferase; catalyzes the terminal step of triacylglycerol formation; flow model biofilm induced; Spider biofilm induced
orf19.6942ORC3Candida albicans SC5314Protein similar to S. cerevisiae Orc3p, which is a component of the origin recognition complex involved in DNA replication; mutation confers hypersensitivity to toxic ergosterol analog; induced under hydroxyurea treatment
Locus IdGene NameOrganismDescription
orf19.563RRP15Candida albicans SC5314Putative nucleolar protein; constituent of pre-60S ribosomal particles; Hap43-induced; repressed by prostaglandins
orf19.3600Candida albicans SC5314Protein of unknown function; flow model biofilm induced
orf19.564KAR3Candida albicans SC5314Kinesin-like microtubule motor protein; required for nuclear fusion during mating; C-terminal motor domain; mutants are viable; null has high-frequency white-opaque switching phenotype
orf19.3601Candida albicans SC5314Protein of unknown function
orf19.6947GTT11Candida albicans SC5314Glutathione S-transferase, localized to ER; induced in exponentially growing cells, under oxidative stress; induced by nitric oxide; Spider biofilm induced
orf19.6948CCC1Candida albicans SC5314Manganese transporter; required for normal filamentous growth; mRNA binds She3, localized to hyphal tips; repressed by NO, alkaline pH; colony morphology-related regulation by Ssn6; regulated by Sef1, Sfu1, Hap43; Spider biofilm induced
orf19.3605PEX17Candida albicans SC5314Putative peroxin
orf19.4262Candida albicans SC5314Protein of unknown function
orf19.4263Candida albicans SC5314Protein of unknown function
orf19.4264Candida albicans SC5314Protein of unknown function; induced during chlamydospore formation in both C. albicans and C. dubliniensis; flow model biofilm induced
orf19.4265UAP1Candida albicans SC5314UDP-N-acetylglucosamine pyrophosphorylase, catalyzes biosynthesis of UDP-N-acetylglucosamine from UTP and N-acetylglucosamine 1-phosphate; functional homolog of S. cerevisiae Qri1p; alkaline upregulated
orf19.5604MDR1Candida albicans SC5314Plasma membrane MDR/MFS multidrug efflux pump; methotrexate is preferred substrate; overexpression in drug-resistant clinical isolates confers fluconazole resistance; repressed in young biofilms; rat catheter biofilm induced
orf19.5605Candida albicans SC5314Protein of unknown function
orf19.6263Candida albicans SC5314Predicted MFS membrane transporter; member of the monocarboxylate porter (MCP) family; Spider biofilm induced
orf19.5608Candida albicans SC5314RNA polymerase III subunit; Spider biofilm induced
orf19.5609Candida albicans SC5314Protein of unknown function
orf19.6267Candida albicans SC5314Protein of unknown function
orf19.6268Candida albicans SC5314Putative cohesin complex subunit; expression downregulated in an ssr1 null mutant
orf19.30SPF1Candida albicans SC5314P-type calcium-transporting ATPase, involved in control of calcium homeostasis, response to ER stress, hyphal growth, biofilm formation and virulence
orf19.35Candida albicans SC5314Predicted kinase; rat catheter, flow model, Spider biofilm induced
Locus IdGene NameOrganismDescription
orf19.5610ARG3Candida albicans SC5314Putative ornithine carbamoyltransferase; Gcn4-regulated; Hap43-induced; repressed in alkalinizing medium; rat catheter and Spider biofilm induced
orf19.5611Candida albicans SC5314Predicted 3-methylbutanol:NAD(P) oxidoreductase and methylglyoxal reductase (NADPH-dependent); role in ergosterol metabolic process; early stage flow model biofilm induced; Spider biofilm induced
orf19.5614Candida albicans SC5314Putative ribonuclease H1; possibly an essential gene, disruptants not obtained by UAU1 method; flow model biofilm induced; Spider biofilm induced
orf19.6271Candida albicans SC5314Protein of unknown function
orf19.5615AYR2Candida albicans SC5314Putative NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase; shows colony morphology-related gene regulation by Ssn6p
orf19.5616Candida albicans SC5314Protein of unknown function
orf19.6273Candida albicans SC5314Protein of unknown function
orf19.5617Candida albicans SC5314Protein of unknown function
orf19.5618Candida albicans SC5314Protein of unknown function
orf19.6277Candida albicans SC5314Protein of unknown function
orf19.5621Candida albicans SC5314Putative protein of unknown function; mutation confers hypersensitivity to amphotericin B; overlaps orf19.5621
orf19.5623ARP4Candida albicans SC5314Subunit of the NuA4 histone acetyltransferase complex
orf19.6280Candida albicans SC5314Dubious open reading frame
orf19.7521REP1Candida albicans SC5314Protein involved in negative regulation of MDR1 transcription; mutants show increased resistance to azole drugs
orf19.7522Candida albicans SC5314Protein with a pyridoxal phosphate-dependent transferase domain; Hap43-repressed; mutation confers hypersensitivity to amphotericin B; Spider biofilm repressed
orf19.7523MKC1Candida albicans SC5314MAP kinase; role in biofilm formation, contact-induced invasive filamentation, systemic virulence in mouse, cell wall structure/maintenance, caspofungin response; phosphorylated on surface contact, membrane perturbation, or cell wall stress
orf19.7527Candida albicans SC5314Protein of unknown function
orf19.7529EPL1Candida albicans SC5314Subunit of the NuA4 histone acetyltransferase complex
orf19.4980HSP70Candida albicans SC5314Putative hsp70 chaperone; role in entry into host cells; heat-shock, amphotericin B, cadmium, ketoconazole-induced; surface localized in yeast and hyphae; antigenic in host; farnesol-downregulated in biofilm; Spider biofilm induced
orf19.4981Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.4982Candida albicans SC5314Protein of unknown function
orf19.4983Candida albicans SC5314Protein of unknown function
orf19.4984Candida albicans SC5314Protein of unknown function
orf19.4985GUP1Candida albicans SC5314Putative O-acyltransferase with a role in glycerol uptake; functionally complements growth of S. cerevisiae gup1 mutant under salt stress; required for normal ergosterol distribution, hyphal growth, biofilm formation
orf19.4987NUP49Candida albicans SC5314Nuclear pore protein
orf19.4988Candida albicans SC5314S. cerevisiae ortholog Sae2 is an endonuclease that processes hairpin DNA structures with the MRX complex, involved in meiotic and mitotic double-strand break repair; upregulated in a cyr1 null mutant
orf19.1646Candida albicans SC5314Protein of unknown function
orf19.1648RAD50Candida albicans SC5314Putative DNA double-strand break repair factor; involved in response to oxidative stress and drug resistance; flow model biofilm repressed
orf19.1649RNA1Candida albicans SC5314Putative GTPase-activating protein; protein level decreases in stationary phase cultures; Spider biofilm repressed
orf19.7534MIS12Candida albicans SC5314Mitochondrial C1-tetrahydrofolate synthase precursor
orf19.7537BNR1Candida albicans SC5314Formin; probable role in hyphal cytoskeletal polarity; synthetic lethality if Bnr1p and Bni1p are absent
orf19.7539INO2Candida albicans SC5314Transcriptional activator that forms a heterodimer with Ino4p; likely regulates genes involved in phosphatidylcholine and phosphatidylinositol biosynthesis, fatty acid beta-oxidation, and peroxisome biogenesis
orf19.4991MPT5Candida albicans SC5314Putative RNA-binding protein; Hap43p-repressed gene; protein induced during the mating process
orf19.3609UTP15Candida albicans SC5314Small subunit (SSU) processome component; mutation confers resistance to 5-fluorocytosine (5-FC); physically interacts with TAP-tagged Nop1p
orf19.4269Candida albicans SC5314Protein of unknown function
orf19.570IFF8Candida albicans SC5314Putative GPI-anchored adhesin-like protein; decreased transcription is observed in an azole-resistant strain that overexpresses MDR1
orf19.6953IRS4Candida albicans SC5314Protein with roles in cell wall integrity, systemic (but not oral) murine infection, adherence, hyphal growth, and agar-embedded filamentous growth; antigenic in human infection; similar to S. cerevisiae Irs4p
orf19.3610Candida albicans SC5314Protein of unknown function; upregulation correlates with clinical development of fluconazole resistance; regulated by Sef1, Sfu1, and Hap43
orf19.6955HBR3Candida albicans SC5314Essential protein; regulated by hemoglobin; S. cerevisiae ortholog is essential; Hap43p-induced gene
orf19.575HYR3Candida albicans SC5314Putative GPI-anchored adhesin-like protein; similar to Hyr1p induced in high iron; clade-specific repeat variation
Locus IdGene NameOrganismDescription
orf19.6956DAL9Candida albicans SC5314Putative allantoate permease; fungal-specific (no human or murine homolog)
orf19.576CTF8Candida albicans SC5314Putative kinetochore protein with a predicted role in sister chromatid cohesion; repressed during the mating process; flow model biofilm induced
orf19.4270MNN13Candida albicans SC5314Predicted alpha-1,3-mannosyltransferase activity with a role in protein glycosylation; regulated by Sef1p-, Sfu1p-, and Hap43p
orf19.577Candida albicans SC5314Predicted protein tyrosine phosphatase; rat catheter biofilm induced
orf19.578Candida albicans SC5314Protein of unknown function
orf19.579FOL1Candida albicans SC5314Putative dihydroneopterin aldolase (dihydro-6-hydroxymethylpterin pyrophosphokinase); fungal-specific (no human or murine homolog)
orf19.4273Candida albicans SC5314Putative mitochondrial membrane protein; ortholog of S. cerevisiae Sls1; coordinates expression of mitochondrially-encoded genes; Hap43-induced
orf19.3617GTR1Candida albicans SC5314Putative GTP-binding protein; transcript is upregulated in clinical isolates from HIV+ patients with oral candidiasis; (see Locus History Note for Assembly 19 correction)
orf19.4274PUT1Candida albicans SC5314Putative proline oxidase; alkaline upregulated by Rim101; flow model biofilm induced; Spider biofilm induced
orf19.3618YWP1Candida albicans SC5314Secreted yeast wall protein; possible role in dispersal in host; mutation increases adhesion and biofilm formation; propeptide; growth phase, phosphate, Ssk1/Ssn6/Efg1/Efh1/Hap43 regulated; mRNA binds She3; flow and Spider biofilm repressed
orf19.4275RAD9Candida albicans SC5314DNA damage-dependent checkpoint protein; involved in regulation of DNA-damage-induced filamentous growth; induced by alpha pheromone in SpiderM medium
orf19.4278Candida albicans SC5314Protein of unknown function
orf19.4279MNN1Candida albicans SC5314Putative alpha-1,3-mannosyltransferase; of the mannosyltransferase complex; negatively regulated by Rim101; transcript elevated in chk1 and nik1 mutants, but not in sln1 mutant; Spider and flow model biofilm induced
orf19.6282Candida albicans SC5314Protein of unknown function
orf19.5626Candida albicans SC5314Protein of unknown function; Plc1-regulated; induced by Mnl1 under weak acid stress; flow model biofilm induced
orf19.5627Candida albicans SC5314S. cerevisiae ortholog Hek2/Khd1 is a putative RNA binding protein involved in the asymmetric localization of ASH1 mRNA; Hap43-induced gene
orf19.5628Candida albicans SC5314Mitochondrial dicarboxylate transporter; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.5629QCR7Candida albicans SC5314Putative ubiquinol-cytochrome-c reductase, subunit 7; Hap43p-repressed gene
orf19.6286Candida albicans SC5314Protein of unknown function
orf19.6288Candida albicans SC5314Dubious open reading frame
Locus IdGene NameOrganismDescription
orf19.53Candida albicans SC5314Protein of unknown function
orf19.54RHD1Candida albicans SC5314Putative beta-mannosyltransferase required for the addition of beta-mannose to the acid-labile fraction of cell wall phosphopeptidomannan; 9-gene family memebr; regulated on yeast-hypha and white-opaque switches; Spider biofilm repressed
orf19.56ARG2Candida albicans SC5314Putative enzyme of arginine biosynthesis; transcription of genes of arginine biosynthesis pathway, except for ARG2, is induced upon phagocytosis by macrophage
orf19.58RRP6Candida albicans SC5314Putative nuclear exosome exonuclease component; Hap43p-induced gene; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine)
orf19.59REI1Candida albicans SC5314Putative cytoplasmic pre-60S factor; Hap43-induced; repressed by prostaglandins
orf19.5633Candida albicans SC5314F-box domain-containing protein; flow model biofilm induced
orf19.5634FRP1Candida albicans SC5314Ferric reductase; alkaline-induced by Rim101; iron-chelation-induced by CCAAT-binding factor; fluconazole-repressed; ciclopirox-, hypoxia-, Hap43-induced; colony morphology-related regulation by Ssn6; Spider and flow model biofilm induced
orf19.5635PGA7Candida albicans SC5314GPI-linked hyphal surface antigen; induced by ciclopirox olamine, ketoconazole, Rim101 at pH 8; Hap43, fluconazole; flow model biofilm induced; Spider biofilm induced; required for RPMI biofilm; Bcr1-induced in a/a biofilm
orf19.5636RBT5Candida albicans SC5314GPI-linked cell wall protein; hemoglobin utilization; Rfg1, Rim101, Tbf1, Fe regulated; Sfu1, Hog1, Tup1, serum, alkaline pH, antifungal drugs, geldamycin repressed; Hap43 induced; required for RPMI biofilms; Spider biofilm induced
orf19.6293EMP24Candida albicans SC5314COPII-coated vesicle component
orf19.6295MAS2Candida albicans SC5314Putative processing peptidase, catalytic (alpha) subunit; protein level decreases in stationary phase cultures
orf19.6296VPS22Candida albicans SC5314ESCRT-II complex protein with a role in multivesicular body (MVB) trafficking; required for processing of Rim8p; Hap43p-repressed gene
orf19.6297Candida albicans SC5314Protein of unknown function
orf19.1650TOM6Candida albicans SC5314Predicted component of the TOM (translocase of outer membrane) complex, involved in protein import into mitochondria
orf19.1651Candida albicans SC5314Protein of unknown function
orf19.4996Candida albicans SC5314Protein of unknown function
orf19.4997KIS2Candida albicans SC5314Scaffold protein of Snf1p complex; similar to S. cerevisiae Gal83p and Sip2p; interacts with Snf4p; interaction with Snf1p complex is regulated by carbon source, decreased on ethanol; N-terminal myristoylation; Hog1p-downregulated
orf19.1655PXP2Candida albicans SC5314Putative acyl-CoA oxidase; enzyme of fatty acid beta-oxidation; induced during macrophage infection; opaque specific transcript; putative peroxisome targeting signal; Spider biofilm induced
orf19.1659ALG8Candida albicans SC5314Putative glucosyltransferase involved in cell wall mannan biosynthesis; transcription is elevated in nik1 and sln1 homozygous null mutants, but not in the chk1 null mutant; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.501Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.504Candida albicans SC5314Protein of unknown function
orf19.506YDJ1Candida albicans SC5314Putative type I HSP40 co-chaperone; heavy metal (cadmium) stress-induced
orf19.7544TLO1Candida albicans SC5314Member of a family of telomere-proximal genes of unknown function; hypha-induced expression; rat catheter biofilm repressed
orf19.7545Candida albicans SC5314Protein similarity to mutator-like element (MULE) transposase
orf19.7546Candida albicans SC5314Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; Spider biofilm induced
orf19.4203Candida albicans SC5314Protein of unknown function
orf19.4204Candida albicans SC5314Protein of unknown function
orf19.7548MED21Candida albicans SC5314Protein of unknown function
orf19.4206Candida albicans SC5314Protein of unknown function
orf19.4208RAD52Candida albicans SC5314Required for homologous DNA recombination, repair of UV- or MMS-damaged DNA, telomere length, UV-induced LOH; constitutive expression, MMS-induced; weakly complements S. cerevisiae rad52 mutant; slow growth, increased white-to-opaque switch
orf19.1662Candida albicans SC5314Protein of unknown function
orf19.1663MNT2Candida albicans SC5314Alpha-1,2-mannosyl transferase; adds 3rd mannose in cell-wall mannoprotein biosynthesis; partially redundant with Mnt1; role in adherence and virulence; expressed in yeast and hyphae; fungal-specific; Hap43-induced; Spider biofilm induced
orf19.1665MNT1Candida albicans SC5314Alpha-1,2-mannosyl transferase; predicted type II Golgi membrane protein; adds 2nd mannose during cell-wall mannoprotein biosynthesis; required for wild-type virulence and adherence to epithelial cells; Hap43-induced
orf19.5158Candida albicans SC5314Protein with similarity to a human gene associated with colon cancer and to orf19.5158; regulated by Gcn4, Cyr1; induced by amino acid starvation; macrophage-induced protein, macrophage-repressed; Spider biofilm induced
orf19.1953Candida albicans SC5314Predicted protein of unknown function; merged with orf19.1952 in Assembly 21
orf19.1954PUS4Candida albicans SC5314Putative pseudouridine synthase; transcript regulated by Nrg1, Mig1, and Tup1
orf19.1956Candida albicans SC5314Protein of unknown function
orf19.1957CYC3Candida albicans SC5314Mitochondrial cytochrome c heme lyase; antigenic cell-wall protein; filament induced; induced on polystyrene adherence, interaction with macrophage; N-glycosylation, 2 heme-binding motifs; rat catheter, Spider biofilm induced
orf19.1959Candida albicans SC5314Protein of unknown function
orf19.802UGA1Candida albicans SC5314Putative GABA transaminase; transcription regulated by Mig1 and Tup1; stationary phase enriched protein; rat catheter and Spider biofilm induced
Locus IdGene NameOrganismDescription
orf19.804Candida albicans SC5314Putative mitochondrial carrier family transporter; rat catheter biofilm induced
orf19.805Candida albicans SC5314Putative protein of unknown function; possibly mitochondrial; Hap43-repressed; Spider biofilm repressed
orf19.806VMA7Candida albicans SC5314Putative subunit of the V-ATPase complex, which is involved in control of vacuolar pH; highly similar to S. cerevisiae Vma7p; interacts with phosphatidylinositol 3-kinase Vps34p
orf19.807CHS5Candida albicans SC5314Putative chitin biosynthesis protein; fungal-specific; repressed upon yeast-to-hypha switch; rat catheter biofilm repressed
orf19.808Candida albicans SC5314Protein of unknown function
orf19.4502Candida albicans SC5314Protein of unknown function
orf19.809Candida albicans SC5314Protein of unknown function
orf19.4503Candida albicans SC5314Similar to HMG-box variant of S. pombe; Spider biofilm repressed
orf19.5160Candida albicans SC5314Protein of unknown function
orf19.4504Candida albicans SC5314Protein of unknown function
orf19.5161Candida albicans SC5314Protein of unknown function
orf19.4505ADH3Candida albicans SC5314Putative NAD-dependent (R,R)-butanediol dehydrogenase; regulated by white-opaque switch; induced by nitric oxide independent of Yhb1; Spider biofilm induced
orf19.5162BCK1Candida albicans SC5314Ortholog of S. cerevisiae Bck1; MAP kinase kinase kinase of cell integrity pathway; mutant is hypersensitive to caspofungin
orf19.5163SFI1Candida albicans SC5314Putative centrin-binding protein; predicted role in spindle pole body duplication; induced by alpha pheromone in SpiderM medium; essential for growth
orf19.5164ECM39Candida albicans SC5314Putative mannosyltransferase similar to S. cerevisiae Ecm39p, which has a role in Calcofluor white resistance; predicted Kex2p substrate; has HKEXRF motif
orf19.3998Candida albicans SC5314Protein of unknown function
orf19.6540PFK2Candida albicans SC5314Phosphofructokinase beta subunit; fructose 2,6-bisphosphate, AMP activated; ATP inhibited; phagocytosis, hyphal repressed; fluconazole-induced; stationary-phase enriched; flow model biofilm induced; rat catheter/Spider biofilm repressed
orf19.3200MTLA2Candida albicans SC5314Master regulator (activator) of a-type mating; has HMG domain, which is predicted to bind DNA; gene has intron; not related to S. cerevisiae MATa2; a/alpha mating type may increase virulence, provides competitive advantage
orf19.6544LPI9Candida albicans SC5314Protein phosphatase type 1 regulator; role in chromosome segregation, regulation of phosphoprotein phosphatase activity; rat catheter and Spider biofilm induced
orf19.3202Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.166ASG1Candida albicans SC5314Gal4p family zinc-finger transcription factor with similarity to S. cerevisiae Asg1p
orf19.3204Candida albicans SC5314Protein of unknown function
orf19.168Candida albicans SC5314Protein of unknown function
orf19.169CHO2Candida albicans SC5314Putative phosphatidyl-ethanolamine N-methyltransferase; fungal-specific (no human or murine homolog); amphotericin B repressed; Hap43p-induced gene
orf19.3207CCN1Candida albicans SC5314G1 cyclin; required for hyphal growth maintenance (not initiation); cell-cycle regulated transcription (G1/S); Cdc28p-Ccn1p initiates Cdc11p S394 phosphorylation on hyphal induction; expression in S. cerevisiae inhibits pheromone response
orf19.3209FGR42Candida albicans SC5314Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth
orf19.172RPC19Candida albicans SC5314Putative RNA polymerases I and III subunit AC19; Hap43-induced; rat catheter biofilm induced
orf19.6552Candida albicans SC5314Flavin-linked sulfhydryl oxidase; predicted localization to endoplasmic reticulum lumen; involved in disulfide bond formation within the ER; Spider biofilm induced
orf19.6553Candida albicans SC5314Membrane-localized protein of unknown function; possibly secreted; fluconazole-induced
orf19.3211RCF3Candida albicans SC5314Putative heteropentameric replication factor C subunit; transcription is induced upon filamentous growth
orf19.175Candida albicans SC5314Protein of unknown function
orf19.3212MID1Candida albicans SC5314Putative stretch-activated Ca2+ channel of the high affinity calcium uptake system; role in thigmotropism; decreased transcription is observed upon fluphenazine treatment or in an azole-resistant strain with CDR1 and CDR2 overexpression
orf19.6556Candida albicans SC5314Protein of unknown function; rat catheter, flow model and Spider biofilm induced
orf19.3213Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.6557Candida albicans SC5314Protein with a predicted fatty acid amide hydrolase I domain; induced by Mnl1 under weak acid stress
orf19.980Candida albicans SC5314Protein of unknown function
orf19.7228Candida albicans SC5314Possible Golgi membrane protein; transcript positively regulated by Tbf1; mRNA binds She3
orf19.986GLY1Candida albicans SC5314L-threonine aldolase; complements glycine auxotrophy of S. cerevisiae shm1 shm2 gly1-1 triple mutant; macrophage/pseudohyphal-induced; the GLY1 locus has an RFLP and is triploid in strain SGY269; flow model biofilm induced
orf19.4680Candida albicans SC5314Possile protease; mutation confers hypersensitivity to toxic ergosterol analog
orf19.4681RAT1Candida albicans SC53145'-->3' exoribonuclease; similar to S. cerevisiae nuclear exoribonuclease Rat1p; suppresses S. cerevisiae kem1 mutant slow growth, mating defect, and haploid invasive growth defect
Locus IdGene NameOrganismDescription
orf19.4682HGT17Candida albicans SC5314Putative MFS family glucose transporter; 20 members in C. albicans; 12 probable membrane-spanning segments; induced at low (0.2%, compared to 2%) glucose in rich media; Spider biofilm induced
orf19.4683MLP1Candida albicans SC5314Protein of unknown function
orf19.1341PRR2Candida albicans SC5314Putative serine/threonine protein kinase; mutation confers resistance to 5-fluorocytosine (5-FC)
orf19.4685Candida albicans SC5314Dubious open reading frame
orf19.4686Candida albicans SC5314Protein of unknown function
orf19.1345LIP8Candida albicans SC5314Secreted lipase, member of a differentially expressed lipase gene family with possible roles in nutrition and/or in creating an acidic microenvironment; LIP5 and LIP8 are expressed at all stages of both mucosal and systemic infection
orf19.4688DAG7Candida albicans SC5314Secretory protein; a-specific, alpha-factor induced; mutation confers hypersensitivity to toxic ergosterol analog; fluconazole-induced; induced during chlamydospore formation in C. albicans and C. dubliniensis
orf19.4689PGA57Candida albicans SC5314Putative GPI-anchored protein; Hap43p-induced gene
orf19.1348Candida albicans SC5314Protein of unknown function
orf19.7232IRR1Candida albicans SC5314Putative cohesin complex subunit; cell-cycle regulated periodic mRNA expression
orf19.7234Candida albicans SC5314Putative RSC chromatin remodeling complex component; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.7236TIF35Candida albicans SC5314Putative translation initiation factor; repressed upon phagocytosis by murine macrophage; Spider biofilm repressed
orf19.991DJP1Candida albicans SC5314Similar to bacterial DnaJ; reported to have a role in peroxisome biogenesis; induced in low iron and upon adherence to polystyrene
orf19.992LKH1Candida albicans SC5314Putative leukotriene A(4) hydrolase; repressed during the mating process; Hog1p-induced
orf19.7238NPL3Candida albicans SC5314Putative RNA-binding protein; required for normal flow model biofilm growth; nuclear export is facilitated by Hmt1p; transcript upregulated in RHE model of oralcandidiasis; Spider biofilm repressed
orf19.3818GOA1Candida albicans SC5314Protein required for respiratory growth, resistance to oxidants, chlamydospore formation, hyphal growth under some conditions, and virulence; relocalizes from the cytoplasm to the mitochondrion during oxidative or osmotic stress
orf19.3819Candida albicans SC5314Protein of unknown function; transcript detected on high-resolution tiling arrays
orf19.4476Candida albicans SC5314Protein with a NADP-dependent oxidoreductase domain; transcript induced by ketoconazole; rat catheter and Spider biofilm induced
orf19.4477CSH1Candida albicans SC5314Aldo-keto reductase; role in fibronectin adhesion, cell surface hydrophobicity; regulated by temperature, growth phase, benomyl, macrophage interaction; azole resistance associated; Spider biofilm induced; rat catheter biofilm repressed
orf19.4478Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.4479Candida albicans SC5314Putative U3-containing 90S preribosome subunit; Hap43-induced; repressed in core stress response; Spider biofilm induced
orf19.1137Candida albicans SC5314Protein of unknown function
orf19.1139Candida albicans SC5314Protein of unknown funtion; S. cerevisiae ortholog Svl3 plays a role in endocytosis and is localized to the bud neck; Spider biofilm induced
orf19.7021GPH1Candida albicans SC5314Putative glycogen phosphorylase; role in glycogen metabolism; regulated by Ssk1, Mig1, Tup1, Hap43; fluconazole-induced; localizes to cell surface of hyphae, not yeast; stationary phase enriched protein; Spider biofilm induced
orf19.7022Candida albicans SC5314Protein of unknown function
orf19.7023Candida albicans SC5314Ortholog of S. cerevisiae Ioc4, a protein that influences gene expression through chromatin remodeling; oxidative stress-induced via Cap1
orf19.7024Candida albicans SC5314Protein of unknown function
orf19.780DUR1,2Candida albicans SC5314Urea amidolyase; hydrolyzes urea to CO2; use of urea as N source and for hyphal switch in macrophage; regulated by Nrg1/Hap43; required for virulence; promotes mouse kidney and brain colonization; rat catheter and flow model biofilm induced
orf19.7027Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.782Candida albicans SC5314Protein of unknown function
orf19.7028Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; merged with orf19.7027 in Assembly 21
orf19.3820Candida albicans SC5314Protein with DNA binding domain, an endonuclease domain; adjacent to CEN4, the centromere region of Chr 4; clade-associated gene expression
orf19.783Candida albicans SC5314Protein of unknown function
orf19.7029Candida albicans SC5314Putative guanine deaminase; mutation confers hypersensitivity to toxic ergosterol analog; Spider biofilm induced
orf19.3822SCS7Candida albicans SC5314Putative ceramide hydroxylase; regulated by Nrg1; induced in high iron; fluconazole-induced; Hap43-repressed; Spider biofilm induced
orf19.3823ZDS1Candida albicans SC5314Nonessential protein; similar to S. cerevisiae Zds1p
orf19.787Candida albicans SC5314Protein of unknown function
orf19.4508Candida albicans SC5314Protein of unknown function
orf19.4509Candida albicans SC5314Protein of unknown function
orf19.5168Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.5169Candida albicans SC5314Protein of unknown function
orf19.1963GDS1Candida albicans SC5314Putative mitochondrial protein; Hap43-repressed gene; Spider biofilm induced
orf19.1967Candida albicans SC5314Protein of unknown function
orf19.1969CCW14Candida albicans SC5314Putative mannoprotein of cell wall with role in response to stress; increased mRNA abundance observed in cyr1 homozygous mutant (hyphal or yeast-form cells) and in ras1 homozygous mutant (yeast-form cells)
orf19.810Candida albicans SC5314Protein of unknown function
orf19.812Candida albicans SC5314Protein of unknown function
orf19.814SSY1Candida albicans SC5314Amino acid sensor; required for wild-type hyphal growth on solid serum or Lees media, not under all conditions; 12 predicted membrane spanning regions; Hap43-repressed; Spider biofilm induced
orf19.4510IFA4Candida albicans SC5314Protein of unknown function; oxidative stress-induced via Cap1
orf19.819Candida albicans SC5314Protein of unknown function
orf19.5170ENA21Candida albicans SC5314Predicted P-type ATPase sodium pump; Gcn4p-regulated; flucytosine, amphotericin B, or ketoconazole-induced; osmotic stress-induced; overlaps orf19.5170.1, which is annotated as a blocked reading frame; Spider biofilm induced
orf19.5171PMT1Candida albicans SC5314Protein mannosyltransferase; required for virulence in mice and for adhesion to epithelial cells; role in hyphal growth and drug sensitivity; Als1, Sec20, Kre9, Pir1 are substrates; 1 of 5 PMT family members
orf19.5172LIP9Candida albicans SC5314Secreted lipase, member of a lipase gene family whose members are expressed differentially in response to carbon source and during infection; may have a role in nutrition and/or in creating an acidic microenvironment
orf19.5174TAF19Candida albicans SC5314Putative TFIID subunit; mutation confers hypersensitivity to amphotericin B; rat catheter biofilm induced
orf19.4518Candida albicans SC5314Protein kinase of unknown function; mutants are viable
orf19.4519SUV3Candida albicans SC5314RNA helicase; mitochondrial RNA catabolism; required for chlamydospore formation, embedded hyphal growth, wild-type respiratory growth, alkaline-induced morphogenesis and SD or Spider biofilm formation; rat catheter biofilm induced
orf19.178Candida albicans SC5314Protein of unknown function
orf19.6558Candida albicans SC5314Protein of unknown function
orf19.6559Candida albicans SC5314RNA polymerase III transcription initiation factor complex (TFIIIC) subunit; growth phase regulated protein; downregulaated in stationary phase yeast cultures; Hap43-repressed; flow model biofilm induced; Spider biofilm repressed
orf19.3218Candida albicans SC5314Putative multidrug resistance protein; upregulated by Efg1p
orf19.5901PKC1Candida albicans SC5314Protein kinase C; functional homolog of S. cerevisiae Pkc1p; mutant has abnormal yeast-form cell morphology and increased cell lysis; activated by phosphatidylserine; target of antifungal, cercosporamide; R400P mutant is activated
Locus IdGene NameOrganismDescription
orf19.5902RAS2Candida albicans SC5314Protein similar to S. cerevisiae Ras2; has opposite effects to Ras1; Tn mutation affects filamentous growth; rat catheter and Spider biofilm induced
orf19.5904RPL19ACandida albicans SC5314Ribosomal protein L19; repressed upon phagocytosis by murine macrophages; Hap43-induced gene; Spider biofilm repressed
orf19.6561LAT1Candida albicans SC5314Putative dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex; sumoylation target; Spider biofilm repressed
orf19.182Candida albicans SC5314Protein of unknown function
orf19.6562RNH35Candida albicans SC5314Putative ribonuclease H2 catalytic subunit; flucytosine induced; Spider biofilm repressed
orf19.5906ADE2Candida albicans SC5314Phosphoribosylaminoimadazole carboxylase; role in adenine biosynthesis; required for normal growth and virulence in immunosuppressed mouse infection; not induced in GCN response, in contrast to S. cerevisiae ADE2; stationary phase-enriched
orf19.183HIS3Candida albicans SC5314Imidazoleglycerol-phosphate dehydratase, enzyme of histidine biosynthesis; functionally complements S. cerevisiae his3-1 mutation; hyphal-induced expression; regulated by Gcn2p and Gcn4p; fungal-specific (no human or murine homolog)
orf19.6563KCH1Candida albicans SC5314Ortholog of Kch1 a potassium transporter; mediates K+ influx and activates high-affinity Ca2+ influx system during mating pheromone response in S. cerevisiae; induced by alpha pheromone in SpiderM medium
orf19.3220Candida albicans SC5314Putative rRNA processing protein; Spider biofilm induced
orf19.184MDM10Candida albicans SC5314Predicted component of the mitochondrial sorting and assembly machinery (SAM complex) and ER-mitochondria encounter structure (ERMES) complex with a role in protein import into mitochondria
orf19.5908TEC1Candida albicans SC5314TEA/ATTS transcription factor; white cell pheromone response, hyphal gene regulation; required for Spider and RPMI biofilm formation; regulates BCR1; Cph2 regulated transcript; alkaline, rat catheter, Spider, flow model biofilm induced
C2_06660W_ACandida albicans SC5314Ortholog(s) have role in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA and LSU-rRNA), more
orf19.996Candida albicans SC5314Protein with a predicted leucine-rich repeat domain; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.997SNL1Candida albicans SC5314Ribosome-associated protein predicted to function in protein synthesis; 1 predicted transmembrane domain; rat catheter biofilm repressed
orf19.998Candida albicans SC5314Putative adapter protein; links synaptojanins Inp52 and Inp53 to the cortical actin cytoskeleton in S. cerevisiae; mutants are viable
orf19.999GCA2Candida albicans SC5314Predicted extracellular glucoamylase; induced by ketoconazole; possibly essential, disruptants not obtained by UAU1 method; promotes biofilm matrix formation; Spider biofilm induced; Bcr1-induced in RPMI a/a biofilms
orf19.1350Candida albicans SC5314Protein with a thioredoxin domain; predicted role in cell redox homeostasis; rat catheter and Spider biofilm induced
orf19.1352TIM22Candida albicans SC5314Mitochondrial inner membrane protein; predicted role in protein import; Hap43-repressed gene; flow model biofilm induced; Spider biofilm repressed
orf19.4697MDN1Candida albicans SC5314Putative midasin, a very large dynein-related AAA-type ATPase; induced during the mating process
orf19.1355Candida albicans SC5314Putative protein of unknown function; stationary phase enriched protein
Locus IdGene NameOrganismDescription
orf19.1356Candida albicans SC5314Protein of unknown function
orf19.1357FCY21Candida albicans SC5314High affinity, high capacity, hypoxanthine-adenine-guanine-cytosine/H+ symporter; similar to S. cerevisiae Fcy2; mutation confers resistance to 5-fluorocytosine (5-FC); flow model biofilm induced
orf19.1358GCN4Candida albicans SC5314bZIP transcription factor; amino acid control response; required for Efg1-dependent pseudohyphal induction by amino acid starvation, not by serum; human whole blood and PMN induced; required for biofilm formation; Spider biofilm induced
orf19.200Candida albicans SC5314Putative nuclear RNA-binding protein; Spider biofilm repressed
orf19.206Candida albicans SC5314Putative adhesin-like protein
orf19.7242NCR1Candida albicans SC5314Putative vacuolar membrane protein; predicted role in sphingolipid metabolism; transcript regulated by Nrg1 and Mig1; induced by prostaglandins
orf19.207PGA55Candida albicans SC5314GPI-anchored adhesin-like protein; filament induced; regulated by Nrg1, Tup1; regulated upon hyphal formation; mRNA binds to She3 and is localized to yeast-form buds and hyphal tips; induced during chlamydospore formation
orf19.7243Candida albicans SC5314Deoxycytidine monophosphate (dCMP) deaminase; role in dUMP and dTMP biosynthesis; Spider biofilm repressed
orf19.7244Candida albicans SC5314Putative fumarylacetoacetate hydrolase; induced by nitric oxide independent of Yhb1; regulated by Sef1, Sfu1, Hap43; flow model biofilm induced
orf19.209DFG10Candida albicans SC5314Protein of unknown function
orf19.7245Candida albicans SC5314Protein of unknown function
orf19.7247RIM101Candida albicans SC5314Transcription factor; alkaline pH response; required for alkaline-induced hyphal growth; role in virulence in mice; activated by C-terminal proteolytic cleavage; mediates both positive and negative regulation; Spider biofilm induced
orf19.4481MFALPHACandida albicans SC5314Alpha factor mating pheromone precursor; three copies of pheromone that are proteolytically processed by Kex2p and possibly by Orf19.5851p; required for alpha cells to mate; expressed specifically in opaque phase MTLalpha/MTLalpha cells
orf19.3825RCE1Candida albicans SC5314Putative Type II CAAX prenyl protease; induced during the mating process
orf19.3826Candida albicans SC5314Predicted transmembrane protein with a role in cell wall polymer composition; Plc1-regulated; Spider biofilm induced
orf19.1140Candida albicans SC5314Protein of unknown function; Spider biofilm repressed
orf19.3829PHR1Candida albicans SC5314Cell surface glycosidase; may act on cell-wall beta-1,3-glucan prior to beta-1,6-glucan linkage; role in systemic, not vaginal virulence (neutral, not low pH); high pH or filamentation induced; Bcr1-repressed in RPMI a/a biofilm
orf19.1143Candida albicans SC5314Protein of unknown function
orf19.1146Candida albicans SC5314Protein of unknown function
orf19.1149MRF1Candida albicans SC5314Putative mitochondrial respiratory protein; induced by farnesol, benomyl, nitric oxide, core stress response; oxidative stress-induced via Cap1; stationary-phase enriched protein; Spider biofilm induced
Locus IdGene NameOrganismDescription
orf19.7030SSR1Candida albicans SC5314Beta-glucan associated ser/thr rich cell-wall protein with a role in cell wall structure; GPI anchor; similar mRNA abundance in yeast-form and germ tubes; detected at germ tube plasma membrane; repressed in cells treated with Congo Red
orf19.7032Candida albicans SC5314Protein of unknown function
orf19.7034Candida albicans SC5314Putative eIF4E-associated protein;, accelerates mRNA degradation by promoting decapping; Spider biofilm repressed
orf19.7035RFC2Candida albicans SC5314Putative heteropentameric replication factor C subunit; periodic mRNA expression, peak at cell-cycle G1/S phase
orf19.7036Candida albicans SC5314Protein of unknown function
orf19.7037YAE1Candida albicans SC5314Protein of unknown function
orf19.792Candida albicans SC5314Protein of unknown function
orf19.793CAK1Candida albicans SC5314Monomeric CDK-activating kinase; functional homolog of S. cerevisiae Cak1p; phosphorylates cyclin-free human CDK2; lacks glycine loop motif; conserved lysine (K36) not required for activity; possibly essential gene (by UAU1 method)
orf19.794SSN3Candida albicans SC5314Putative cyclin-dependent protein kinase; mutants are sensitive to growth on H2O2 medium
orf19.797BAT21Candida albicans SC5314Putative branched chain amino acid aminotransferase; regulated by Gcn4, Gcn2; induced in response to amino acid starvation (3-aminotriazole treatment); early-stage flow model biofilm formation
orf19.4492Candida albicans SC5314Protein of unknown function
orf19.3838EFB1Candida albicans SC5314Translation elongation factor EF-1 beta; repressed by human whole blood or PMNs; macrophage/pseudohyphal-induced; antigenic in mouse; farnesol-downregulated; snoRNA snR18 is encoded within the EFB1 intron; Spider biofilm repressed
orf19.5178ERG5Candida albicans SC5314Putative C-22 sterol desaturase; fungal C-22 sterol desaturases are cytochrome P450 enzymes of ergosterol biosynthesis, catalyze formation of the C-22(23) double bond in the sterol side chain; transposon mutation affects filamentous growth
orf19.1970Candida albicans SC5314Putative vacuole biogenesis protein
orf19.1975Candida albicans SC5314Protein of unknown function
orf19.1976TRX2Candida albicans SC5314Similar to thioredoxins; not expected to be enzymatically active because it lacks a canonical thioredoxin active site (Trp-Cys-Gly-Pro-Cys); TRX1 encodes all of the cytoplasmic/nuclear thioredoxin function in C. albicans; Hap43p-induced
orf19.1978GIT2Candida albicans SC5314Putative glycerophosphoinositol permease; fungal-specific; repressed by alpha pheromone in SpiderM medium; Hap43-repressed; Spider biofilm induced
orf19.820SDS22Candida albicans SC5314Putative protein serine-threonine phosphatase; macrophage/pseudohyphal-repressed
orf19.825GCD7Candida albicans SC5314Putative translation initiator; downregulated in the presence of human whole blood or polymorphonuclear (PMN) cells
orf19.4520Candida albicans SC5314Putative gluconokinase; rat catheter biofilm induced
Locus IdGene NameOrganismDescription
orf19.4521Candida albicans SC5314S. cerevisiae ortholog Env9 has similarity to oxidoreductases and is proposed to have vacuolar functions, found in lipid particles; hyphal-induced expression
orf19.828Candida albicans SC5314Putative ribosomal protein, large subunit, mitochondrial precursor; repressed by prostaglandins; Spider biofilm repressed
orf19.829SCH9Candida albicans SC5314Protein kinase; involved in growth control, cell size, resistance to rapamycin, cations, chlamydospore formation, filamentous growth under some conditions, and virulence; prevents hyphal growth in hypoxia at high CO2; Spider biofilm induced
orf19.4523Candida albicans SC5314Protein of unknown function
orf19.5180PRX1Candida albicans SC5314Thioredoxin peroxidase; transcriptionally induced by interaction with macrophage; fluconazole induced; Fkh2p-downregulated; caspofungin repressed; protein present in exponential and stationary growth phase yeast cultures
orf19.4524ZCF24Candida albicans SC5314Predicted Zn(II)2Cys6 transcription factor; caspofungin induced; Hap43-repressed
orf19.5181NIK1Candida albicans SC5314Histidine kinase involved in a two-component signaling pathway that regulates cell wall biosynthesis; required for wild-type virulence in mouse systemic infection but not for wild-type growth or drug sensitivity/resistance; 9 HAMP domains
orf19.4525Candida albicans SC5314Protein of unknown function
orf19.5182POL3Candida albicans SC5314Large subunit of DNA polymerase III; partially complements defects of an S. cerevisiae cdc2 mutant; differing reports about periodic (G1/S) or non-periodic mRNA expression through cell cycle; Hap43p-repressed
orf19.4526HSP30Candida albicans SC5314Putative heat shock protein; fluconazole repressed; amphotericin B induced; Spider biofilm induced; rat catheter biofilm induced
orf19.4527HGT1Candida albicans SC5314High-affinity MFS glucose transporter; induced by progesterone, chloramphenicol, benomyl; likely essential for growth; protein newly produced during adaptation to the serum; rat catheter and Spider biofilm induced
orf19.5184Candida albicans SC5314Putative Ran guanyl-nucleotide exchange factor; probable signal transducer; Spider biofilm repressed
orf19.3221CPA2Candida albicans SC5314Putative arginine-specific carbamoylphosphate synthetase; protein enriched in stationary phase yeast cultures; rat catheter biofilm induced; Spider biofilm induced
orf19.185Candida albicans SC5314Protein of unknown function
orf19.6565Candida albicans SC5314Conserved mitochondrial inner membrane insertase; mediates insertion of mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane; Spider biofilm repressed
orf19.3222Candida albicans SC5314Predicted vacuolar protein; rat catheter biofilm repressed; flow model biofilm repressed
orf19.6566Candida albicans SC5314Protein of unknown function
orf19.3223ATP3Candida albicans SC5314F1-ATP synthase complex subunit; caspofungin repressed; flucytosine and macrophage/pseudohyphal-induced; present in exponential and stationary growth phases; Hap43p-induced gene
orf19.187Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; merged with orf19.188 in Assembly 21
orf19.6568SMC6Candida albicans SC5314Putative structural maintenance of chromosomes (SMC) protein; Hap43-induced; cell-cycle regulated periodic mRNA expression; S. cerevisiae ortholog not cell-cycle regulated; Spider biofilm induced
Locus IdGene NameOrganismDescription
orf19.188Candida albicans SC5314Protein of unknown function
orf19.3229Candida albicans SC5314Protein of unknown function; transcript detected on high-resolution tiling arrays
orf19.5910Candida albicans SC5314Putative histone acetyltransferase complex subunit; induced upon low-level peroxide stress; Spider biofilm induced
orf19.6570NUPCandida albicans SC5314Nucleoside permease; adenosine and guanosine are substrates, whereas cytidine, adenine, guanine, uridine, uracil are not; similar to a nucleoside permease of S. pombe; possibly processed by Kex2p
orf19.5915DUR35Candida albicans SC5314Putative urea transporter
orf19.193Candida albicans SC5314Protein of unknown function
orf19.5917STP1Candida albicans SC5314Transcription factor; regulates SAP2, OPT1 expression and thereby protein catabolism for nitrogen source; activated via amino-acid-induced proteolytic processing; macrophage/pseudohyphal-repressed; Spider biofilm repressed
orf19.6574ALK6Candida albicans SC5314Putative cytochrome P-450 of N-alkane-induced detoxification; macrophage-induced gene
orf19.3231CDC27Candida albicans SC5314Putative ubiquitin-protein ligase; periodic mRNA expression, peak at cell-cycle S/G2 phase
orf19.6577FLU1Candida albicans SC5314Multidrug efflux pump of the plasma membrane; MDR family member of the MFS (major facilitator superfamily) of transporters; involved in histatin 5 efflux; fungal-specific (no human/murine homolog)
orf19.6579Candida albicans SC5314Protein of unknown function
orf19.3237Candida albicans SC5314Protein of unknown function
orf19.1361TIM23Candida albicans SC5314Protein involved in mitochondrial matrix protein import
orf19.1362SMM1Candida albicans SC5314Putative dihydrouridine synthase; Hap43-induced gene; rat catheter biofilm induced; Spider biofilm induced
orf19.1363Candida albicans SC5314Putative protein of unknown function; Plc1-regulated; transcript induced by Mnl1 under weak acid stress; flow model, rat catheter, Spider biofilm induced
orf19.1364Candida albicans SC5314Ortholog of S. pombe Stm1 G-protein coupled receptor; PQ-loop domains; constitutive expression independent of MTL or white-opaque status; Hap43-repressed
orf19.1365Candida albicans SC5314Putative monooxygenase; mutation confers hypersensitivity to toxic ergosterol analog; constitutive expression independent of MTL or white-opaque status
orf19.1367MTW1Candida albicans SC5314Kinetochore component; amount of Nuf2p and Mtw1p protein detected at each centromere is consistent with a single kinetochore microtubule attachment site
orf19.1369Candida albicans SC5314Protein with predicted peptidase domains; Hap43-repressed gene
orf19.210Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.212VPS28Candida albicans SC5314ESCRT I protein sorting complex subunit; involved in Rim8 processing and proteolytic activation of Rim101, which regulates pH response; role in echinocandin, azole sensitivity
orf19.7250Candida albicans SC5314Protein of unknown function; rat catheter and Spider biofilm induced
orf19.215Candida albicans SC5314Component of a complex containing the Tor2p kinase; possible a role in regulation of cell growth; Spider biofilm induced
orf19.7251WSC4Candida albicans SC5314Putative cell wall integrity and stress response subunit 4 precursor; transcription is specific to white cell type
orf19.7252Candida albicans SC5314Protein of unknown function
orf19.217Candida albicans SC5314Protein of unknown function
orf19.7254Candida albicans SC5314Protein of unknown function
orf19.7255RPC10Candida albicans SC5314Putative RNA polymerase subunit ABC10-alpha of RNA polymerase complexes I, II, and III; flucytosine induced; Spider biofilm induced
orf19.7258DDI1Candida albicans SC5314Putative DNA damage inducible v-SNARE binding protein; macrophage/pseudohyphal-repressed
orf19.1372Candida albicans SC5314Protein of unknown function; transcript regulated by Mig1 and Tup1
orf19.1376Candida albicans SC5314Protein of unknown function
orf19.1377IPK2Candida albicans SC5314Putative inositol polyphosphate multikinase; moderately induced at 42 deg
orf19.220PIR1Candida albicans SC53141,3-beta-glucan-linked cell wall protein; N-mannosylated, O-glycosylated by Pmt1; cell wall defect in het mutant; Hog1/fluconazole/hypoxia induced; iron/Efg1/Plc1/temp regulated; flow model biofilm induced; hyphal, Spider biofilm repressed
orf19.6600Candida albicans SC5314Protein of unknown function
orf19.223Candida albicans SC5314Putative serine/threonine protein kinase; Hap43-repressed; induced by prostaglandins; possibly an essential gene, disruptants not obtained by UAU1 method; flow model biofilm induced; Spider biofilm induced
orf19.4495NDH51Candida albicans SC5314Nicotinamide adenine dinucleotide dehydrogenase complex I subunit of the mitochondrial electron transport chain; required for wild-type filamentous growth; alkaline repressed; Hap43-repressed; Spider biofilm repressed
orf19.3839SAP10Candida albicans SC5314Secreted aspartyl protease; roles in adhesion, virulence (RHE model), cell surface integrity; distinct specificity from Sap9; at cell membrane and wall; GPI-anchored; induced in low iron; Tbf1-activated; Spider biofilm induced
orf19.4496Candida albicans SC5314Protein of unknown function
orf19.4497MED8Candida albicans SC5314Protein of unknown function
orf19.1155DPP2Candida albicans SC5314Protein similar to S. cerevisiae pyrophosphate phosphatase Lpp1p; possible role in farnesol biosynthesis
Locus IdGene NameOrganismDescription
orf19.1156FUS1Candida albicans SC5314Membrane protein required for mating; ortholog of S. cerevisiae Fus1; transcript induced by Cph1 in cells homozygous for the MTLa locus; alpha factor induced
orf19.1159Candida albicans SC5314Protein similar to A. nidulans CysA serine O-trans-acetylase; suggests that C. albicans uses an O-acetyl-serine (OAS) pathway of sulfur assimilation; F-12/CO2 early biofilm induced; Spider biofilm induced
orf19.7041Candida albicans SC5314Putative pre-tRNA processing protein; heterozygous null mutant exhibits hypersensitivity to parnafungin and cordycepin in the C. albicans fitness test
orf19.7043Candida albicans SC5314Protein of unknown function
orf19.7044RIM15Candida albicans SC5314Protein of unknown function
orf19.7047RTF1Candida albicans SC5314Putative RNA polymerase II-associated Paf1 complex subunit; induced during the mating process
orf19.3840Candida albicans SC5314Putative serine/threonine kinase similar to S. cerevisiae Sak1; possibly an essential gene, disruptants not obtained by UAU1 method; Spider biofilm induced
orf19.7049CYB5Candida albicans SC5314Cytochrome b(5); ortholog of S. cerevisiae Cyb5; induced in high iron; fluconazole-induced; shows colony morphology-related gene regulation by Ssn6; mutants are viable
orf19.3843Candida albicans SC5314Protein of unknown function
orf19.3844MRP8Candida albicans SC5314Mitochondrial ribosomal protein; ortholog of S. cerevisiae Mrp8; transcript induced in hyphal form; mutant is viable; flow model and rat catheter biofilm repressed
orf19.3845FGR3Candida albicans SC5314Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth
orf19.3846LYS4Candida albicans SC5314Homoaconitase; regulated by Gcn4, Gcn2; induced in response to amino acid starvation (3-AT); induced by human whole blood or PMNs; Hap43-repressed; flow model and Spider biofilm repressed
orf19.1160Candida albicans SC5314Protein of unknown function
orf19.3848Candida albicans SC5314Protein of unknown function
orf19.4528Candida albicans SC5314Protein of unknown function
orf19.4529Candida albicans SC5314Ortholog of Srp21, signal recognition particle subunit, functions in protein targeting to the endoplasmic reticulum membrane; predicted adhesin-like protein; mutants are viable
orf19.5188CHS1Candida albicans SC5314Chitin synthase; essential; for primary septum synthesis in yeast and hyphae; 1 of several chitin synthases; enzymatically activated by proteolytic processing; complements defects of S. cerevisiae chs1 or chs2; Spider biofilm repressed
orf19.1981IMP2Candida albicans SC5314Predicted subunit of the mitochondrial inner membrane peptidase complex involved in protein targeting to mitochondria
orf19.1985Candida albicans SC5314Has aminoglycoside phosphotransferase and protein kinase domains; rat catheter and flow model biofilm induced
orf19.1988CDC45Candida albicans SC5314Putative DNA replication initiation factor; transcriptionally regulated by interaction with macrophage
Locus IdGene NameOrganismDescription
orf19.1989DCW1Candida albicans SC5314Protein with predicted GPI modification; dfg5 dcw1 double mutant is inviable; not required for wild-type hyphal growth; upregulated in cyr1 mutant (yeast or hyphal form); Hap43-induced
orf19.832GPI13Candida albicans SC5314Major facilitator superfamily protein; has phosphodiesterase/nucleotide pyrophosphatase domain; similar to S. cerevisiae Gpi13p, which acts in GPI anchor biosynthesis; Hap43p-induced gene
orf19.834Candida albicans SC5314Protein of unknown function
orf19.835Candida albicans SC5314Protein of unknown function
orf19.837GNA1Candida albicans SC5314Glucosamine-6-phosphate acetyltransferase; enzyme of UDP-GlcNAc biosynthesis; required for viability in absence of GlcNAc supplementation; required for persistent infection and wild-type virulence in mouse systemic infection
orf19.4531Candida albicans SC5314Putative PDR-subfamily ABC transporter; Spider biofilm induced
orf19.5190Candida albicans SC5314Protein of unknown function
orf19.4534Candida albicans SC5314Putative UBX-domain (ubiquitin-regulatory domain) protein; macrophage-downregulated gene
orf19.4535PTR3Candida albicans SC5314Protein similar to S. cerevisiae Ptr3p, which is a sensor of external amino acids; expression upregulated in an ssr1 null mutant
orf19.4536CYS4Candida albicans SC5314Cystathionine beta-synthase; sulfur amino acid biosynthesis; antigenic in mouse; flow model biofilm induced; alkaline induced; macrophage/pseudohyphal-induced; present in exponential and stationary growth phase yeast cultures
orf19.5197APE2Candida albicans SC5314Neutral arginine, alanine, leucine specific metallo-aminopeptidase; purified from cell wall/intracellular fractions; protein repressed during mating; Hog1, farnesol-induced; may be essential (UAU1 method); rat catheter biofilm repressed
orf19.1990SNX4Candida albicans SC5314Putative sorting nexin; induced during the mating process
orf19.1993Candida albicans SC5314Protein of unknown function
orf19.3238Candida albicans SC5314Protein of unknown function
orf19.5920Candida albicans SC5314Protein of unknown function
orf19.6580Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.6581Candida albicans SC5314Protein of unknown function
orf19.5925Candida albicans SC5314Protein of unknown function
orf19.5926ARG11Candida albicans SC5314Putative ornithine transporter of the mitochondrial inner membrane; induced during the mating process
orf19.6583Candida albicans SC5314Protein of unknown function; induced by alpha pheromone in SpiderM medium
Locus IdGene NameOrganismDescription
orf19.3240ERG27Candida albicans SC53143-Keto sterol reductase of ergosterol biosynthesis; acts in C-4 sterol demethylation with Erg25p and Erg26p; possible drug target, essential for viability; functional homolog of S. cerevisiae Erg27p
orf19.5928RPP2BCandida albicans SC5314Conserved acidic ribosomal protein; possibly involved in regulation of translation elongation; interacts with Rpp1A; 1 of 4 similar C. albicans proteins (Rpp1A, Rpp1B, Rpp2A, Rpp2B); macrophage/pseudohyphal-induced; Spider biofilm repressed
orf19.3241Candida albicans SC5314Protein of unknown function
orf19.5929Candida albicans SC5314Putative protein of unknown function, transcription is positively regulated by Tbf1p
orf19.6587GIR2Candida albicans SC5314Ortholog of S. cerevisiae Gir2; transposon mutation affects filamentous growth
orf19.3244Candida albicans SC5314Protein of unknown function
orf19.3245Candida albicans SC5314Protein of unknown function
orf19.6589SSF1Candida albicans SC5314Protein involved in ribosome biogenesis; ortholog of S. cerevisiae Ssf1; Hap43-induced; rat catheter and Spider biofilm induced
orf19.3248Candida albicans SC5314Protein of unknown function
orf19.3249LAG1Candida albicans SC5314Putative ceramide synthase component; Hap43p-repressed gene; amphotericin B repressed
orf19.5930Candida albicans SC5314Protein of unknown function
orf19.5931ARV1Candida albicans SC5314Lipid transporter involved in sterol trafficking and transport of glycosylphosphatidylinositol and sphingolipid precursors
orf19.5932Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.5934Candida albicans SC5314Protein of unknown function
orf19.6592Candida albicans SC5314Predicted membrane transporter, member of the aromatic acid:proton symporter (AAHS) family, major facilitator superfamily (MFS)
C6_02810C_ACandida albicans SC5314Ortholog of C. dubliniensis CD36 : Cd36_63300, Candida tropicalis MYA-3404 : CTRG_05769 and Candida albicans WO-1 : CAWG_05077
C1_02400C_AMNN11Candida albicans SC5314Ortholog(s) have alpha-1,6-mannosyltransferase activity, role in cell wall mannoprotein biosynthetic process, protein N-linked glycosylation and alpha-1,6-mannosyltransferase complex, endoplasmic reticulum localization
orf19.7260Candida albicans SC5314Protein with a predicted NADP-dependent oxidoreductase or aldo-keto reductase domain; Hap43-repressed; Spider biofilm repressed
orf19.6604Candida albicans SC5314Ortholog of S. cerevisiae Pba1 that is involved in 20S proteasome assembly; upregulated in a cyr1 null mutant; contains a 5' UTR intron
orf19.7261GDI1Candida albicans SC5314Putative Rab GDP-dissociation inhibitor; GlcNAc-induced protein; Spider biofilm repressed
Locus IdGene NameOrganismDescription
orf19.6605Candida albicans SC5314Protein of unknown function
orf19.227COX7Candida albicans SC5314Putative cytochrome c oxidase; flucytosine induced; repressed by nitric oxide
orf19.7263Candida albicans SC5314Putative X-Pro aminopeptidase; Spider biofilm repressed
orf19.229Candida albicans SC5314Protein of unknown function
orf19.7266Candida albicans SC5314Protein of unknown function
orf19.7267SAM35Candida albicans SC5314Predicted component of the sorting and assembly machinery (SAM complex) of the mitochondrial outer membrane, involved in protein import into mitochondria
orf19.1382YEA4Candida albicans SC5314Putative uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter; required for cell wall chitin synthesis; induced by alpha pheromone in SpiderM medium
orf19.1386Candida albicans SC5314Protein of unknown function
orf19.230Candida albicans SC5314Ortholog of S. cerevisiae Pet111; a mitochondrial translational activator specific for the COX2 mRNA; Hap43-induced gene
orf19.6610Candida albicans SC5314Protein of unknown function
orf19.231APL2Candida albicans SC5314Phosphorylated protein of unknown function; mutation confers hypersensitivity to toxic ergosterol analog
orf19.234PHA2Candida albicans SC5314Putative prephenate dehydratase; Hap43p-repressed gene; expression downregulated in an ssr1 null mutant
orf19.236RPL9BCandida albicans SC5314Ribosomal protein L9; repressed upon phagocytosis by murine macrophages; repressed by nitric oxide; protein levels decrease in stationary phase; Hap43-induced; Spider biofilm repressed
orf19.7272Candida albicans SC5314Protein of unknown function; transcript detected on high-resolution tiling arrays
orf19.238CCP1Candida albicans SC5314Cytochrome-c peroxidase N terminus; Rim101, alkaline pH repressed; induced in low iron or by macrophage interaction; oxygen-induced activity; regulated by Sef1, Sfu1, and Hap43; Spider biofilm induced; rat catheter biofilm repressed
orf19.7274Candida albicans SC5314Predicted ORF in retrotransposon Zorro2 with similarity to retroviral reverse transcriptase proteins
orf19.239Candida albicans SC5314Putative ATP-dependent helicase; induced by nitric oxide
orf19.7275FGR24Candida albicans SC5314Protein encoded in retrotransposon Zorro2 with similarity to retroviral endonuclease-reverse transcriptase proteins; lacks an ortholog in S. cerevisiae; transposon mutation affects filamentous growth
orf19.1166CTA3Candida albicans SC5314Protein similar to S. cerevisiae Ede1p, which is involved in endocytosis; activates transcription in 1-hybrid assay in S. cerevisiae
orf19.1168ZCF3Candida albicans SC5314Zn(II)2Cys6 domain transcription factor; required for filamentous growth, resistance to rapamycin and flucytosine; possibly an essential gene, disruptants not obtained by UAU1 method; Hap43-repressed; Spider and flow model biofilm induced
Locus IdGene NameOrganismDescription
orf19.1169Candida albicans SC5314Putative DnaJ-like molecular chaperone; Spider biofilm induced
orf19.7051Candida albicans SC5314Maf-like protein; rat catheter biofilm induced
orf19.7052Candida albicans SC5314Putative polyphosphatidylinositol phosphatase; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.7054Candida albicans SC5314Dubious open reading frame
orf19.7055Candida albicans SC5314Dubious open reading frame
orf19.7056Candida albicans SC5314Putative protein of unknown function; transcript is upregulated in clinical isolates from HIV+ patients with oral candidiasis; regulated by Sef1, Sfu1, and Hap43
orf19.7058Candida albicans SC5314Protein of unknown function
orf19.7059Candida albicans SC5314Protein of unknown function
orf19.3852Candida albicans SC5314Protein of unknown function
orf19.3856CDC28Candida albicans SC5314Cyclin-dependent protein kinase; interacts with regulatory subunit Cyb1; determination of cell morphology during the cell cycle; phosphorylated mostly by Swe1 and phosphorylation is regulated by Hsl1; 5'-UTR intron; Spider biofilm repressed
orf19.1170ARO7Candida albicans SC5314Putative chorismate mutase; fungal-specific (no human or murine homolog); alkaline upregulated
orf19.1171BTA1Candida albicans SC5314Protein of unknown function
orf19.1177Candida albicans SC5314Ortholog of S. cerevisiae Rtt106; histone chaperone that regulates chromatin structure in transcribed and silenced chromosomal regions; affects transcriptional elongation; Hap43-repressed; Spider biofilm repressed
orf19.1178Candida albicans SC5314Putative transcription factor with bZIP DNA-binding motif; Hap43p-repressed gene
orf19.6400Candida albicans SC5314Protein of unknown function
orf19.7060Candida albicans SC5314Protein of unknown function
orf19.6404GSH2Candida albicans SC5314Putative glutathione synthase; induced in high iron; heavy metal (cadmium) stress-induced
orf19.7061Candida albicans SC5314Protein of unknown function
orf19.7062RPA135Candida albicans SC5314Putative RNA polymerase I subunit A135; repressed by prostaglandins
orf19.1994Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.1996CHA1Candida albicans SC5314Similar to catabolic ser/thr dehydratases; repressed by Rim101; induced in low iron; regulated on white-opaque switch; filament induced; Tn mutation affects filamentation; flow model biofilm induced; Spider biofilm repressed
orf19.1998Candida albicans SC5314Protein of unknown function
orf19.840RPL21ACandida albicans SC5314Putative ribosomal protein; repressed upon phagocytosis by murine macrophage; Spider biofilm repressed
orf19.842ASR3Candida albicans SC5314Adenylyl cyclase and stress responsive protein; induced in cyr1 or ras1 mutant; Spider biofilm induced
orf19.843Candida albicans SC5314Putative DNA repair exonuclease; fungal-specific (no human or murine homolog)
orf19.846Candida albicans SC5314Predicted protein kinase similar to S. cerevisiae Nnk1; implicated in proteasome function in S. cerevisiae; induced by Mnl1 under weak acid stress
orf19.847YIM1Candida albicans SC5314Protein similar to protease of mitochondrial inner membrane; increased transcription is observed upon benomyl treatment; macrophage-downregulated gene
orf19.4542Candida albicans SC5314Protein of unknown function
orf19.849Candida albicans SC5314Protein of unknown function
orf19.1201Candida albicans SC5314Protein of unknown function
orf19.4545SWI4Candida albicans SC5314Putative component of the SBF transcription complex involved in G1/S cell-cycle progression; periodic mRNA expression, peak at cell-cycle G1/S phase; predicted, conserved MBF binding sites upstream of G1/S-regulated genes
orf19.1204Candida albicans SC5314Phosphorylated protein of unknown function; transcript is upregulated clinical isolates from HIV positive patients with oral candidiasis
orf19.4548MAK32Candida albicans SC5314Putative protein involved in the structural stability of L-A double-stranded RNA-containing particles; downregulated upon adherence to polystyrene
orf19.4549FGR38Candida albicans SC5314Protein lacking an ortholog in S. cerevisiae; member of a family of related proteins; transposon mutation affects filamentous growth; macrophage-induced gene; Hap43p-repressed gene
orf19.1207Candida albicans SC5314Protein of unknown function
orf19.1208Candida albicans SC5314Predicted ORF in the Major Repeat Sequence on chromosome 4; member of a family encoded by FGR6-related genes in the RB2 repeat sequence
orf19.6594PLB3Candida albicans SC5314GPI-anchored cell surface phospholipase B; possibly secreted; fungal-specific (no mammalian homolog); induced by Tbf1; fluconazole-induced; possible essential gene (UAU1 method); Spider and flow model biofilm induced
orf19.3252DAL81Candida albicans SC5314Zn(II)2Cys6 transcription factor; ortholog of S. cerevisiae Dal81, involved in the regulation of nitrogen-degradation genes; required for yeast cell adherence to silicone substrate; Spider biofilm induced
orf19.6597Candida albicans SC5314Protein of unknown function
orf19.6598WAL1Candida albicans SC5314Protein required for hyphal growth and for wild-type cell morphology, polarized budding, endocytosis, vacuole morphology; similar to Wiskott-Aldrich syndrome protein; localizes to cortical actin patches and hyphal tips
Locus IdGene NameOrganismDescription
orf19.3256SLN1Candida albicans SC5314Histidine kinase involved in a two-component signaling pathway that regulates cell wall biosynthesis; mutants are sensitive to growth on H2O2 medium; rat catheter and Spider biofilm induced
orf19.5940ZCF32Candida albicans SC5314Predicted Zn(II)2Cys6 transcription factor; possibly an essential gene, disruptants not obtained by UAU1 method; Hap43-repressed
orf19.5943Candida albicans SC5314Protein of unknown function
orf19.2601HEM1Candida albicans SC5314Putative 5-aminolevulinate synthase; caspofungin repressed; induced by high iron, nitric oxide; regulated by Ssn6; Hap43-repressed; Spider biofilm induced
orf19.5947SEC7Candida albicans SC5314Putative guanine nucleotide exchange factor (GEF); mutation confers hypersensitivity to Brefeldin A; caspofungin repressed
orf19.2604Candida albicans SC5314S. pombe ortholog SPAC2C4.06c is a predicted tRNA (cytosine-5-)-methyltransferase; Spider biofilm induced
orf19.2605PRK1Candida albicans SC5314Putative protein serine/threonine kinase; mutants sensitive to growth on hydrogen peroxide medium
orf19.5949FAS2Candida albicans SC5314Alpha subunit of fatty-acid synthase; required for virulence in mouse systemic infection and rat oropharyngeal infection models; regulated by Efg1; fluconazole-induced; amphotericin B repressed; flow model and Spider biofilm repressed
orf19.3263ATO10Candida albicans SC5314Putative fungal-specific transmembrane protein; rat catheter and Spider biofilm induced
orf19.2608ADH5Candida albicans SC5314Putative alcohol dehydrogenase; regulated by white-opaque switch; fluconazole-induced; antigenic in murine infection; regulated by Nrg1, Tup1; Hap43, macrophage repressed, flow model biofilm induced; Spider biofilm induced
orf19.2609CET1Candida albicans SC5314mRNA 5'-triphosphatase; large subunit of mRNA capping enzyme; positively regulates Ceg1 activity; functional homolog of S. cerevisiae Cet1; Cet1 and Cgt1 form a 2:1 complex; flow model biofilm induced
orf19.3266Candida albicans SC5314Protein of unknown function
orf19.3268TMA19Candida albicans SC5314Cell wall protein, ortholog of S. cerevisiae Tma19p (Ykl065cp)
orf19.5952Candida albicans SC5314Protein of unknown function; induced by nitric oxide independent of Yhb1; Sef1, Sfu1, and Hap43-induced; rat catheter and Spider biofilm induced
orf19.2610Candida albicans SC5314Putative tRNA binding protein; intron-containing gene; Spider biofilm induced
orf19.1390PMI1Candida albicans SC5314Phosphomannose isomerase; cell wall biosynthesis enzyme; drug target; functional homolog of S. cerevisiae, E. coli phosphomannose isomerase; Gcn4-regulated; induced on adherence to polystyrene, phagocytosis; 3-AT, Spider biofilm repressed
orf19.1392Candida albicans SC5314Protein of unknown function
orf19.1393Candida albicans SC5314Protein of unknown function
orf19.1395Candida albicans SC5314Protein of unknown function
orf19.1397Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.240PAM17Candida albicans SC5314Predicted component of the presequence translocase-associated import motor (PAM complex) involved in protein import into mitochondrial matrix
orf19.6621MHP1Candida albicans SC5314Protein similar to S. cerevisiae Mhp1p, which is involved in microtubule stabilization; transposon mutation affects filamentous growth; possibly transcriptionally regulated upon hyphal formation; possibly an essential gene (by UAU1 method)
orf19.6623Candida albicans SC5314Protein of unknown function
orf19.7280Candida albicans SC5314Protein of unknown function
orf19.6624Candida albicans SC5314Protein of unknown function
orf19.7281PDK2Candida albicans SC5314Putative pyruvate dehydrogenase kinase; mutation confers hypersensitivity to amphotericin B
orf19.6625Candida albicans SC5314Protein of unknown function
orf19.7282PEX13Candida albicans SC5314Protein required for peroxisomal protein import mediated by PTS1 and PTS2 targeting sequences; transcript induced in an RHE model of oral candidiasis; Hap43-repressed gene
orf19.7283Candida albicans SC5314Protein of unknown function; rat catheter and Spider biofilm induced
orf19.7284ASR2Candida albicans SC5314Adenylyl cyclase and stress responsive protein; induced in cyr1 or ras1 mutant; stationary phase enriched protein; Spider biofilm induced
orf19.6628Candida albicans SC5314Protein of unknown function; rat catheter biofilm repressed
orf19.6629ISC1Candida albicans SC5314Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C; hydrolyzes complex sphingolipids to produce ceramide; mutant is viable
orf19.7286RPN7Candida albicans SC5314Subunit of the proteasome regulatory particle; regulated by Gcn2p and Gcn4p; protein present in exponential and stationary growth phase yeast cultures
orf19.7288Candida albicans SC5314Protein with predicted oxidoreductase and dehydrogenase domains; Hap43-repressed; Spider biofilm induced
orf19.250SLC1Candida albicans SC5314Putative fatty acyltransferase; protein repressed during the mating process
orf19.6406Candida albicans SC5314Protein of unknown function
orf19.6407Candida albicans SC5314Protein of unknown function
orf19.7064GLN4Candida albicans SC5314Putative tRNA-Gln synthetase; genes encoding ribosomal subunits, translation factors, tRNA synthetases are downregulated upon phagocytosis by murine macrophage; protein present in exponential and stationary growth phase yeast cultures
orf19.7065PSF3Candida albicans SC5314Putative GINS complex subunit; cell-cycle regulated periodic mRNA expression; Spider biofilm induced
orf19.7067Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.7069Candida albicans SC5314Putative AdoMet-dependent proline methyltransferase; Hap43-induced; required for normal flow model biofilm growth; Spider biofilm repressed
orf19.3861SIS1Candida albicans SC5314Putative Type II HSP40 co-chaperone; macrophage/pseudohyphal-repressed; heavy metal (cadmium) stress-induced; heterozygous null mutant displays sensitivity to virgineone; rat catheter biofilm induced
orf19.3863Candida albicans SC5314Protein of unknown function
orf19.3867RPL7Candida albicans SC5314Ribosomal protein L7; repressed upon phagocytosis by murine macrophages; Hap43-induced; rat catheter and Spider biofilm induced
orf19.1181Candida albicans SC5314Protein of unknown function
orf19.1183Candida albicans SC5314Protein of unknown function
orf19.1189Candida albicans SC5314Protein of unknown function; regulated by yeast-hypha switch; induced by Mnl1 in weak acid stress; 5' UTR intron; repressed by chlamydospore formation in C. albicans and C. dubliniensis; rat catheter, Spider and flow model biofilm induced
orf19.6411Candida albicans SC5314Protein similar to S. cerevisiae Vac14p; a protein involved in regulated synthesis of PtdIns(3,5)P(2); transposon mutation affects filamentous growth
orf19.6413Candida albicans SC5314Protein of unknown function; rat catheter biofilm induced
orf19.6414Candida albicans SC5314Protein of unknown function
orf19.6416Candida albicans SC5314Protein involved in N-glycosylation; Spider biofilm induced; rat catheter biofilm repressed
orf19.7073Candida albicans SC5314Protein of unknown function
orf19.6417TSR1Candida albicans SC5314Component of 20S pre-rRNA processing unit; repressed by prostaglandins
orf19.7074Candida albicans SC5314Protein of unknown function
orf19.6418Candida albicans SC5314Protein of unknown function
orf19.7077Candida albicans SC5314Putative ferric reductase; induced by Mac1 under copper starvation; Plc1-regulated; Rim101-repressed
orf19.7078Candida albicans SC5314Protein of unknown function
orf19.3870ADE13Candida albicans SC5314Adenylosuccinate lyase; enzyme of adenine biosynthesis; soluble protein in hyphae; not induced during GCN response, in contrast to the S. cerevisiae ortholog; repressed by nitric oxide
orf19.850Candida albicans SC5314Protein of unknown function
orf19.851Candida albicans SC5314Protein of unknown function; repressed by Rim101; negatively modulates intracellular ATP levels during the development of azole resistance; induced by Ca(2+) in a calcineurin-dependent manner; Spider biofilm induced
Locus IdGene NameOrganismDescription
orf19.854UGA11Candida albicans SC5314Putative gamma-aminobutyrate (GABA) transaminase; macrophage-induced; overlaps orf19.854.1, which is a region annotated as a blocked reading frame; Spider biofilm induced
orf19.4550Candida albicans SC5314Predicted MFS membrane transporter, member of the drug:proton antiporter (12 spanner) (DHA1) family; flow model biofilm induced
orf19.4551CTN1Candida albicans SC5314Carnitine acetyl transferase; required for growth on nonfermentable carbon sources, not for hyphal growth or virulence in mice; induced in macrophage; macrophage/pseudohyphal-repressed after 16 hr; rat catheter, Spider biofilm induced
orf19.4553Candida albicans SC5314Protein of unknown function
orf19.1210Candida albicans SC5314Protein of unknown function
orf19.4555ALS4Candida albicans SC5314GPI-anchored adhesin; role in adhesion, germ tube induction; growth, temperature regulated; expressed during infection of human buccal epithelial cells; repressed by vaginal contact; biofilm induced; repressed during chlamydospore formation
orf19.1212Candida albicans SC5314Protein of unknown function
orf19.4557Candida albicans SC5314Protein of unknown function
orf19.1214Candida albicans SC5314Protein of unknown function
orf19.1215Candida albicans SC5314Protein of unknown function
orf19.1217Candida albicans SC5314Protein of unknown function
orf19.1219Candida albicans SC5314Protein of unknown function
orf19.7100Candida albicans SC5314Putative vacuolar transporter of large neutral amino acids; possibly transcriptionally regulated upon hyphal formation; not the true Avt1 ortholog of S. cerevisiae
orf19.7104Candida albicans SC5314Adhesin-like cell wall protein; similar to mucins and to a Litomosoides microfilarial sheath protein; N-terminal secretion signal; rat catheter and Spider biofilm repressed
orf19.2611MCM6Candida albicans SC5314Putative MCM DNA replication initiation complex component; mRNA expression peak at cell-cycle M/G1 phase; regulated by tyrosol and cell density; repressed by alpha pheromone in SpiderM medium; Hap43-induced gene
orf19.2612Candida albicans SC5314C2H2 zinc finger transcription factor; expression reduced in ssr1 null mutant; flow model biofilm induced
orf19.2615MDL1Candida albicans SC5314Putative mitochondrial, half-size MDR-subfamily ABC transporter
orf19.5959NOP14Candida albicans SC5314Putative nucleolar protein; Hap43-induced; mutation confers resistance to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine); heterozygous mutant is resistant to parnafungin; Spider biofilm induced
orf19.3272Candida albicans SC5314Protein of unknown function
orf19.2618MET2Candida albicans SC5314Homoserine acetyltransferase; Hap43p-, Gcn4p-regulated; macrophage/pseudohyphal-repressed; not highly biofilm induced, in contrast to many sulfur amino acid metabolic genes; no human or murine homolog; virulence-group-correlated expression
Locus IdGene NameOrganismDescription
orf19.2619PHO113Candida albicans SC5314Putative constitutive acid phosphatase; Rim101-repressed; DTT-extractable; N-glycosylated; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.3275Candida albicans SC5314Protein of unknown function
orf19.3277Candida albicans SC5314Protein of unknown function
orf19.3279HYR4Candida albicans SC5314Putative GPI-anchored adhesin-like protein; Rim101-repressed; constitutive expression independent of MTL or white-opaque status
orf19.5961Candida albicans SC5314Protein of unknown function
orf19.5962HGT4Candida albicans SC5314Glucose and galactose sensor; fermentation, filamentation, virulence roles; 20-member glucose transporter family; extended C terminus; high-glucose repressed; macrophage induced; flow model biofilm repressed; Spider biofilm induced
orf19.5963Candida albicans SC5314Putative prenyltransferase; essential gene in S. cerevisiae; Spider biofilm induced
orf19.2620Candida albicans SC5314Protein of unknown function
orf19.5964ARF2Candida albicans SC5314Putative ADP-ribosylation factor; mutation confers hypersensitivity to Brefeldin A; Spider biofilm repressed
orf19.2621Candida albicans SC5314Protein of unknown function
orf19.5965Candida albicans SC5314Protein of unknown function
orf19.5966Candida albicans SC5314Protein of unknown function
orf19.2623ECM22Candida albicans SC5314Zn(II)2Cys6 transcription factor; rat catheter and Spider biofilm induced
orf19.5967FGR44Candida albicans SC5314Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth
orf19.5968RDI1Candida albicans SC5314Putative rho GDP dissociation inhibitor; transposon mutation affects filamentous growth; farnesol, filament-induced; regulated by Nrg1, Tup1; protein levels low in stationary phase yeast
orf19.252Candida albicans SC5314Protein of unknown function; S. cerevisiae ortholog Fmp37 which localizes to mitochondria; Hap43-repressed; Spider biofilm repressed
orf19.254Candida albicans SC5314Protein of unknown function; Hog1p-repressed; Spider biofilm induced
orf19.7290Candida albicans SC5314Protein of unknown function
orf19.255ZCF1Candida albicans SC5314Zn(II)2Cys6 transcription factor; transcript regulated during hypha formation; 5'-UTR intron; mutants show decreased colonization of mouse kidneys; flow model biofilm induced; Spider biofilm induced
orf19.7291Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.7292ARP2Candida albicans SC5314Component of the Arp2/3 complex; required for virulence, hyphal growth, cell wall/cytoskeleton organization, not for endocytosis; mutation confers hypersensitivity to cytochalasin D; regulated by Gcn2 and Gcn4; Spider biofilm repressed
orf19.7293MPS1Candida albicans SC5314Monopolar spindle protein, a putative kinase; essential for growth; periodic mRNA expression, peak at cell-cycle S/G2 phase
orf19.6637Candida albicans SC5314Predicted glycosyl hydrolase; hypoxia induced; flow model biofilm induced
orf19.6638PTC4Candida albicans SC5314Type PP2C serine/threonine phosphatase; localized to mitochondria; mutation causes sensitivity to sodium, potassium and azole drugs; decreased expression in hyphae compared to yeast-form cells
orf19.7295Candida albicans SC5314Protein of unknown function
orf19.6639Candida albicans SC5314Ortholog of S. cerevisiae Mdm36; mitochondrial distribution and morphology protein; Hap43-repressed gene
orf19.7297Candida albicans SC5314Putative cystathionine gamma-synthase; decreased levels in stationary phase cultures; Hog1p-induced; Gcn4p-regulated
orf19.7298CHS2Candida albicans SC5314Chitin synthase; nonessential; required for wild-type chitin deposition in hyphae; transcript regulated during dimorphic transition; Chs1 and Chs2, but not Chs3, are inhibited by the protoberberine HWY-289; flow model biofilm repressed
orf19.6640TPS1Candida albicans SC5314Trehalose-6-phosphate synthase; role in hyphal growth and virulence in mouse systemic infection; induced in presence of human neutrophils; macrophage/pseudohyphal-repressed after 16h; stationary phase enriched protein; Hap43-repressed
orf19.261Candida albicans SC5314Protein of unknown function
orf19.262SMC3Candida albicans SC5314Protein similar to S. cerevisiae Smc3p, which is an ATPase involved in sister chromatid cohesion; likely to be essential for growth, based on an insertional mutagenesis strategy
orf19.6642Candida albicans SC5314Protein of unknown function
orf19.6643MCT1Candida albicans SC5314Putative malonyl-CoA acyl carrier protein acyltransferase
orf19.264Candida albicans SC5314Protein of unknown function
orf19.7079Candida albicans SC5314Protein of unknown function
orf19.3871DAD3Candida albicans SC5314Subunit of the Dam1 (DASH) complex, which acts in chromosome segregation by coupling kinetochores to spindle microtubules
orf19.3873ARC40Candida albicans SC5314Protein similar to S. cerevisiae Arc40; involved in actin filament organization in S. cerevisiae; transposon mutation affects filamentous growth; rat catheter and Spider biofilm repressed
orf19.3876ZCF19Candida albicans SC5314Predicted Zn(II)2Cys6 transcription factor
orf19.3877Candida albicans SC5314Protein of unknown function
orf19.1193GNP1Candida albicans SC5314Similar to asparagine and glutamine permease; fluconazole, caspofungin induced; regulated by Nrg1, Mig1, Tup1, Gcn2, Gcn4, and alkaline regulated by Rim101; repressed during chlamydospore formation; rat catheter, flow model biofilm induced
Locus IdGene NameOrganismDescription
orf19.1195Candida albicans SC5314Protein of unknown function
orf19.1198Candida albicans SC5314Predicted mitochondrial intermembrane space protein of unknown function; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.6420PGA13Candida albicans SC5314GPI-anchored cell wall protein involved in cell wall synthesis; required for normal cell surface properties; induced in oralpharyngeal candidasis; Spider biofilm induced; Bcr1-repressed in RPMI a/a biofilms
orf19.6422SSY5Candida albicans SC5314Protein of unknown function
orf19.7080LEU2Candida albicans SC5314Isopropyl malate dehydrogenase; leucine biosynthesis; induced by human whole blood or PMNs; protein level decreases in stationary phase; GlcNAc-induced protein; flow model biofilm repressed
orf19.6424Candida albicans SC5314Protein of unknown function
orf19.6425SKI2Candida albicans SC5314Protein of unknown function
orf19.7084DFI1Candida albicans SC5314Cell-surface associated glycoprotein; promotes activation of Cek1 in a matrix-dependent manner; N-glycosylated; Spider biofilm induced
orf19.7089PMR1Candida albicans SC5314Putative secretory pathway P-type Ca2+/Mn2+-ATPase; required for protein glycosylation and cell wall maintenance; required for hyphal tip oscillation in semisolid substrate; putative ortholog of S. cerevisiae PMR1
orf19.3884FGR50Candida albicans SC5314Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth; Spider biofilm repressed
orf19.3885Candida albicans SC5314Has domain(s) with predicted N-acetyltransferase activity; highly induced during chlamydospore formation in both C. albicans and C. dubliniensis
orf19.3887Candida albicans SC5314Protein of unknown function
orf19.6431Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.6434PEX19Candida albicans SC5314Protein of unknown function
orf19.7092Candida albicans SC5314Putative NAD dependent epimerase/dehydratase family protein; Spider biofilm repressed
orf19.5935Candida albicans SC5314Protein of unknown function
orf19.7105FAR1Candida albicans SC5314Protein involved in regulation of pheromone-mediated mating; repressed by A1p and Alpha2p in white-phase cells; null mutant shows no pheromone response in opaque cells; overexpression causes enhanced pheromone response and cell cycle arrest
orf19.861CAP4Candida albicans SC5314Predicted bZip transcription factor; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.862Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.7107Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.3900Candida albicans SC5314Protein of unknown function
orf19.7109Candida albicans SC5314Protein of unknown function
orf19.3901Candida albicans SC5314Putative benzene desulfurase; induced by nitric oxide independent of Yhb1p
orf19.866RAD32Candida albicans SC5314Protein similar to S. cerevisiae protein with role in nucleotide excision repair; down-regulation associated with azole resistance; Hap43p-repressed gene
orf19.4560BFR1Candida albicans SC5314Protein involved in the maintenance of normal ploidy; S. cerevisiae ortholog cofers Brefeldin A resistance; stationary phase enriched protein; Spider biofilm repressed
orf19.867Candida albicans SC5314Protein of unknown function
orf19.868ADAECCandida albicans SC5314Protein of unknown function; transcription is specific to white cell type
orf19.4563Candida albicans SC5314Protein of unknown function; repressed by prostaglandins; Hap43-induced, Spider biofilm induced
orf19.3908MRV8Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.1221ALG2Candida albicans SC5314Putative mannosyltransferase involved in cell wall mannan biosynthesis; transcription is elevated in chk1, nik1, and sln1 homozygous null mutants
orf19.4566Candida albicans SC5314Protein similar to S. cerevisiae Rot1p, which has roles in cytoskeletal dynamics and cell wall biosynthesis; predicted Kex2p substrate
orf19.4567Candida albicans SC5314Catechol 1,2-dioxygenase (1,2-CTD), involved in degradation of aromatic compounds; Spider biofilm induced
orf19.4568ZCF25Candida albicans SC5314Putative Zn(II)2Cys6 transcription factor
orf19.1228HAP2Candida albicans SC5314CCAAT-binding transcription factor; regulates low-iron induction of FRP1; in these conditions CBF comprises Hap43 and probably Hap2 and Hap3; possibly essential, disruptants not obtained by UAU1 method; Cap1-dependent induction in low iron
orf19.1229Candida albicans SC5314Protein of unknown function
orf19.7111Candida albicans SC5314Putative mitochondrial outer membrane protein membrane fission effector; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.2625Candida albicans SC5314Protein of unknown function
orf19.3282BMT3Candida albicans SC5314Beta-mannosyltransferase; adds 2nd beta-mannose to the acid-stable fraction of cell wall phosphopeptidomannan, elongation of beta-mannose chains on the phosphopeptidomannan acid-labile fraction; Hap43-induced; Spider biofilm induced
orf19.3283Candida albicans SC5314Protein of unknown function
orf19.2629USO1Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.3286Candida albicans SC5314Protein of unknown function
orf19.3288NMA111Candida albicans SC5314Putative serine protease and general molecular chaperone; macrophage-induced gene; repressed in core stress response; merged with orf19.3288.1 in Assembly 21
orf19.3289Candida albicans SC5314Phosphorylated protein of unknown function
orf19.5971Candida albicans SC5314Protein of unknown function
orf19.2630RAD59Candida albicans SC5314Protein involved in homologous recombination and DNA breaks repair; similar to S. cerevisiae Rad59p; N-terminal similarity with Rad52p
orf19.5974ATG9Candida albicans SC5314Protein similar to S. cerevisiae Atg9; required for early step in autophagy; required for cytoplasm to vacuole trafficking of Lap41; Spider biofilm induced
orf19.2631Candida albicans SC5314Subunit of Elongator complex; required for modification of wobble nucleosides in tRNA in S. cerevisiae; Hap43-induced gene
orf19.3292Candida albicans SC5314Protein of unknown function
orf19.3293Candida albicans SC5314Putative enoyl reductase involved in very long chain fatty acid elongation; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.2639Candida albicans SC5314Protein of unknown function
orf19.3296Candida albicans SC5314Protein of unknown function
orf19.3298CCH1Candida albicans SC5314Voltage-gated Ca2+ channel of the high affinity calcium uptake system; roles in thigmotropism, establishment of galvanotropism; transcript regulated by Nrg1 and Mig1; flow model biofilm repressed
orf19.5980Candida albicans SC5314Protein of unknown function; Hap43-repressed gene
orf19.2640FUR1Candida albicans SC5314Uracil phosphoribosyltransferase; predicted tetrameric enzyme of pyrimidine salvage; mutations associated with flucytosine resistance in clade I clinical isolates; flucytosine, macrophage-induced protein; levels decrease in stationary phase
orf19.2641ARP1Candida albicans SC5314Putative centractin; induced upon adherence to polystyrene
orf19.2642Candida albicans SC5314Protein of unknown function
orf19.5776TOM1Candida albicans SC5314Putative E3 ubiquitin ligase; transcript regulated by Nrg1 and Mig1
orf19.2433Candida albicans SC5314Protein of unknown function
orf19.2434NPL4Candida albicans SC5314Putative ubiquitin-binding protein; regulated by Gcn2p and Gcn4p
orf19.2435MSI3Candida albicans SC5314Essential HSP70 family protein; required for fluconazole resistance and calcineurin-dependent transcription; interacts with Cgr1; transcript regulated by iron; rat catheter biofilm induced; farnesol repressed in biofilm; sumoylation target
Locus IdGene NameOrganismDescription
orf19.2436Candida albicans SC5314Predicted protein serine/threonine kinase; Spider biofilm induced
orf19.2437ARC35Candida albicans SC5314Putative ARP2/3 complex subunit; shows colony morphology-related gene regulation by Ssn6p; mutation confers hypersensitivity to cytochalasin D
orf19.3098Candida albicans SC5314Predicted RNA-dependent ATPase RNA helicase; Hap43-induced gene
orf19.5780Candida albicans SC5314Putative protein of unknown function; Hap43p-repressed gene
orf19.5782Candida albicans SC5314Protein of unknown function
orf19.2443RGD1Candida albicans SC5314GTPase activator protein; transcript induced in low iron; alkaline upregulated; localized to the bud emergence area in G1 phase and in the bud tip during S and G2 phases
orf19.5788EFT2Candida albicans SC5314Elongation Factor 2 (eEF2); GTPase; essential; highly expressed; target of sordarin antifungals; antigenic in human/mouse; lacks site for regulatory phosphorylation by eEF2 kinase; GCN-regulated; higher protein amount in stationary phase
orf19.5789ADE8Candida albicans SC5314Putative phosphoribosylglycinamide formyl-transferase, enzyme of amino acid biosynthesis pathway; upregulated in biofilm; S. cerevisiae ortholog is Gcn4p regulated; protein enriched in stationary phase yeast-form cultures
orf19.2446Candida albicans SC5314Protein of unknown function
orf19.2449Candida albicans SC5314Putative adhesin-like protein; macrophage-induced gene
orf19.5792SMP3Candida albicans SC5314Mannosyltransferase of glycosylphosphatidylinositol (GPI) biosynthesis; catalyzes mannosylation of Man3-GPI precursor; essential for viability; 8-9 transmembrane regions predicted; has HQEXRF motif; functional homolog of S. cerevisiae Smp3p
orf19.5793PR26Candida albicans SC5314Protein with similarity to proteasomal 26S regulatory subunit of S. cerevisiae, H. sapiens, Methanobacterium thermoautotrophicum (Archaebacterium)
orf19.2452Candida albicans SC5314Protein of unknown function; induced in high iron; repressed in core caspofungin response; ketoconazole-repressed; colony morphology-related gene regulation by Ssn6; possibly subject to Kex2 processing
orf19.5797PLC2Candida albicans SC5314Phosphatidylinositol (PtdIns)-specific phospholipase C (PI-PLC); predicted type 2 membrane protein; role in, and regulated by, filamentation, Nrg1 and Tup1; no mouse systemic virulence role; orf19.5797 and orf19.1586 are almost identical
orf19.7093HGT13Candida albicans SC5314Predicted sugar transporter, involved in glycerol utilization; member of the major facilitator superfamily; 12 transmembrane; gene has intron; oxidative stress-induced via Cap1p; expressed in rich medium, 2% glucose
orf19.6437CDC23Candida albicans SC5314Similar to anaphase-promoting complex component; possibly transcriptionally regulated by Tac1p
orf19.6438Candida albicans SC5314Protein of unknown function
orf19.7096Candida albicans SC5314Protein of unknown function
orf19.7098Candida albicans SC5314Putative protein of unknown function; Hap43-repressed; repressed by nitric oxide; Spider biofilm induced
orf19.3893SCW11Candida albicans SC5314Cell wall protein; repressed in ace2 mutant; repressed in core caspofungin response; induced in high iron; possibly an essential gene, disruptants not obtained by UAU1 method; rat catheter and Spider biofilm repressed
Locus IdGene NameOrganismDescription
orf19.3894Candida albicans SC5314Putative inositol oxygenase; mutation confers hypersensitivity to toxic ergosterol analog; Spider biofilm induced
orf19.3899SDC1Candida albicans SC5314Putative COMPASS/SET1C histone methyltransferase complex subunit
orf19.6440Candida albicans SC5314Protein of unknown function
orf19.6443Candida albicans SC5314Protein with an enoyl-CoA hydratase related domain; Spider biofilm induced
orf19.6444Candida albicans SC5314Protein of unknown function
orf19.6445ECI1Candida albicans SC5314Protein similar to S. cerevisiae Eci1p, which is involved in fatty acid oxidation; transposon mutation affects filamentous growth; expression is regulated upon white-opaque switching
orf19.3102CTA6Candida albicans SC5314Protein that activates transcription in 1-hybrid assay in S. cerevisiae
orf19.3103Candida albicans SC5314Protein of unknown function
orf19.6447ARF1Candida albicans SC5314ADP-ribosylation factor; probable GTPase involved in intracellular transport; one of several C. albicans ADP-ribosylation factors; N-myristoylprotein; substrate of Nmt1; Spider biofilm induced
orf19.3104YDC1Candida albicans SC5314Alkaline dihydroceramidase; involved in sphingolipid metabolism; Mob2-dependent hyphal regulation; transcript is regulated by Nrg1 and Mig1; Hap43-repressed
orf19.6448Candida albicans SC5314Protein of unknown function; Spider biofilm repressed
orf19.3105Candida albicans SC5314Putative cytochrome P450 protein; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.6449Candida albicans SC5314Protein of unknown function
orf19.3106MET16Candida albicans SC5314Putative 3'-phosphoadenylsulfate reductase; sulfur amino acid metabolism; reports differ on regulation during biofilm formation; fungal-specific; possibly an essential gene, disruptants not obtained by UAU1 method; Hap43p-repressed gene
orf19.3107Candida albicans SC5314Protein of unknown function
orf19.3108Candida albicans SC5314Putative DNA repair methyltransferase; induced by nitric oxide independent of Yhb1; Spider biofilm induced
orf19.7112FRP2Candida albicans SC5314Putative ferric reductase; alkaline induced by Rim101; fluconazole-downregulated; upregulated in the presence of human neutrophils; possibly adherence-induced; regulated by Sef1, Sfu1, and Hap43
orf19.7114CSA1Candida albicans SC5314Surface antigen on elongating hyphae and buds; strain variation in repeat number; ciclopirox, filament induced, alkaline induced by Rim101; Efg1-, Cph1, Hap43-regulated; required for WT RPMI biofilm formation; Bcr1-induced in a/a biofilms
orf19.7115SAC7Candida albicans SC5314Putative GTPase activating protein (GAP) for Rho1; repressed upon adherence to polystyrene; macrophage/pseudohyphal-repressed; transcript is upregulated in RHE model of oral candidiasis and in clinical oral candidiasis
orf19.7116Candida albicans SC5314Protein of unknown function; transcript induced in RHE model of oral candidiasis; Spider biofilm repressed
Locus IdGene NameOrganismDescription
orf19.872Candida albicans SC5314Protein of unknown function
orf19.7118Candida albicans SC5314Protein of unknown function
orf19.3910Candida albicans SC5314Protein of unknown function
orf19.7119RAD3Candida albicans SC5314Ortholog of S. cerevisiae Rad3; 5' to 3' DNA helicase, nucleotide excision repair and transcription, subunit of RNA polII initiation factor TFIIH and Nucleotide Excision Repair Factor 3 (NEF3)
orf19.874Candida albicans SC5314Predicted mitochondrial i-AAA protease supercomplex; degrades misfolded mitochondrial proteins; Hap43-repressed gene
orf19.3912GLN3Candida albicans SC5314GATA transcription factor, involved in regulation of nitrogen starvation-induced filamentous growth; regulates transcription of Mep2 ammonium permease; regulated by Gcn2 and Gcn4; mRNA binds She3; Spider biofilm induced
orf19.875Candida albicans SC5314Protein required for respiratory growth
orf19.876PGA33Candida albicans SC5314Putative GPI-anchored protein of unknown function; Spider biofilm repressed
orf19.4570Candida albicans SC5314Protein of unknown function
orf19.878NBN1Candida albicans SC5314Subunit of the NuA4 histone acetyltransferase complex; Plc1p-regulated
orf19.879Candida albicans SC5314Protein of unknown function
orf19.4575Candida albicans SC5314Protein of unknown function
orf19.1232VRG4Candida albicans SC5314GDP-mannose transporter; essential; required for glycosylation, hyphal growth; functional homolog of S. cerevisiae Vrg4p, which imports GDP-mannose from cytoplasm to Golgi for protein and lipid mannosylation; no mammalian homolog
orf19.4577Candida albicans SC5314Protein of unknown function
orf19.1234FGR6-10Candida albicans SC5314Protein lacking an ortholog in S. cerevisiae; member of a family encoded by FGR6-related genes in the RB2 repeat sequence; transposon mutation affects filamentous growth
orf19.1235HOM3Candida albicans SC5314Putative L-aspartate 4-P-transferase; fungal-specific (no human or murine homolog); regulated by Gcn2 and Gcn4; early-stage flow model biofilm induced
orf19.1236GVP36Candida albicans SC5314BAR domain protein; ocalizes to early and late Golgi vesicles; predicted role in adaptation to varying nutrient concentrations, fluid-phase endocytosis, actin cytoskeleton polarization and vacuole biogenesis; rat catheter biofilm repressed
orf19.5986THI4Candida albicans SC5314Thiamine biosynthetic enzyme precursor; repressed during the mating process; stationary phase enriched protein; Spider biofilm induced
orf19.5987Candida albicans SC5314Protein of unknown function
orf19.2645Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.5989Candida albicans SC5314Putative cleavage factor I subunit; required for the cleavage and polyadenylation of pre-mRNA 3' ends; Spider biofilm repressed
orf19.2647ZCF14Candida albicans SC5314Putative Zn(II)2Cys6 transcription factor; caspofungin induced
orf19.5991Candida albicans SC5314Protein of unknown function
orf19.2650Candida albicans SC5314Protein of unknown function; rat catheter biofilm induced
orf19.2651CAM1-1Candida albicans SC5314Putative translation elongation factor; downregulated upon phagocytosis by murine macrophages; Hap43-induced gene; Spider biofilm repressed
orf19.2654RMS1Candida albicans SC5314Putative lysine methyltransferase; Hap43-induced; protein induced during mating; possibly essential, disruptants not obtained by UAU1 method; rat catheter and Spider biofilm induced
orf19.2655BUB3Candida albicans SC5314Protein similar to S. cerevisiae Bub3; a kinetochore checkpoint component; induced by hydroxyurea treatment; flow model biofilm induced; Spider biofilm induced
orf19.2657Candida albicans SC5314Protein of unknown function
orf19.5200SIT4Candida albicans SC5314Serine/threonine protein phosphatase catalytic subunit; has a role in cell wall maintenance, hyphal growth, and virulence in a mouse systemic infection model
orf19.5201Candida albicans SC5314Protein of unknown function
orf19.5204Candida albicans SC5314Protein of unknown function
orf19.5205Candida albicans SC5314Protein of unknown function; Hap43-repressed gene
orf19.5206Candida albicans SC5314Putative chaperone protein; role in the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing; Spider biofilm induced
orf19.5209Candida albicans SC5314Protein of unknown function
orf19.2660EAF3Candida albicans SC5314Subunit of the NuA4 histone acetyltransferase complex; rat catheter and Spider biofilm induced
orf19.2662Candida albicans SC5314Predicted ORF of unknown function; overlaps TLO34/orf19.2661
orf19.2664Candida albicans SC5314Protein of unknown function
orf19.2667RPF1Candida albicans SC5314Putative nucleolar protein with a predicted role in the assembly and export of the large ribosomal subunit; essential for growth; rat catheter and Spider biofilm induced
orf19.2669Candida albicans SC5314ORF in retrotransposon Tca4; similar to Pol region of retrotransposons encoding reverse transcriptase, protease, integrase; downstream of RHD2, similar to the Gag region encoding nucleocapsid-like protein; rat catheter biofilm induced
orf19.5210Candida albicans SC5314Putative Xbp1 transcriptional repressor; binds to cyclin gene promoters in S. cerevisiae; Hap43-repressed; possibly essential, disruptants not obtained by UAU1 method
Locus IdGene NameOrganismDescription
orf19.5212Candida albicans SC5314Protein of unknown function
orf19.2454PHO87Candida albicans SC5314Putative phosphate permease; transcript repressed by Rim101 at pH 8; regulated by white-opaque switch; caspofungin repressed; virulence-group-correlated expression; flow model biofilm induced
orf19.2455Candida albicans SC5314Protein of unknown function
orf19.2457Candida albicans SC5314Protein of unknown function; induced during chlamydospore formation in both C. albicans and C. dubliniensis; Spider biofilm induced
orf19.5001CUP2Candida albicans SC5314Putative copper-binding transcription factor; required for normal resistance to copper; activates transcription of metallothionein genes; Hap43-repressed; Spider biofilm induced
orf19.5003Candida albicans SC5314Protein of unknown function
orf19.5005OSM2Candida albicans SC5314Putative mitochondrial fumarate reductase; regulated by Ssn6p, Gcn2p, and Gcn4p; Hog1p-downregulated; stationary phase enriched protein; Hap43p-repressed gene
orf19.5007ACT1Candida albicans SC5314Actin; gene has intron; transcript regulated by growth phase, starvation; at polarized growth site in budding and hyphal cells; required for wild-type Cdc42 localization; unprocessed N terminus; Hap43-induced; Spider biofilm repressed
orf19.5009Candida albicans SC5314Protein of unknown function
orf19.1802OFD1Candida albicans SC5314Putative prolyl hydroxylase family member; regulates Ume6p stability in response to oxygen; inhibited by hypoxia; repressed by prostaglandins; Spider biofilm induced
orf19.1803CDC43Candida albicans SC5314Beta subunit of heterodimeric protein geranylgeranyltransferase type I; GGTase I enzyme binds zinc, is Mg-dependent; Cdc42p is GGTase I substrate
orf19.1804Candida albicans SC5314Protein of unknown function
orf19.1805PEX14Candida albicans SC5314Protein of unknown function
orf19.2462PRN3Candida albicans SC5314Protein similar to pirin; induced by Mnl1 under weak acid stress; Hap43-repressed; Spider biofilm induced
orf19.2463PRN2Candida albicans SC5314Protein similar to pirin; Hap43p-repressed gene
orf19.2465POL32Candida albicans SC5314Putative subunit of DNA polymerase delta, involved in chromosomal DNA replication; cell-cycle regulated periodic mRNA expression
orf19.2467PRN1Candida albicans SC5314Protein with similarity to pirins; induced by benomyl and in response to alpha pheromone in SpiderM medium; transcript induced by Mnl1 in weak acid stress; rat catheter and Spider biofilm induced
orf19.2468Candida albicans SC5314Protein of unknown function
orf19.2469RAD10Candida albicans SC5314Ortholog of S. cerevisiae Rad10, an endonuclease involved in nucleotide excision repair; mutant is extremely sensitive to UV irradiation; transcript repressed in alkaline conditions
orf19.5010DIM1Candida albicans SC5314Putative 18S rRNA dimethylase; predicted role in rRNA modification and processing; Hap43-induced; likely to be essential for growth based on insertional mutagenesis strategy; F-12/CO2 early biofilm induced
Locus IdGene NameOrganismDescription
orf19.5012Candida albicans SC5314Protein of unknown function
orf19.3109Candida albicans SC5314Protein of unknown function
orf19.6453Candida albicans SC5314Protein of unknown function
orf19.3111PRA1Candida albicans SC5314Cell surface protein that sequesters zinc from host tissue; enriched at hyphal tips; released extracellularly; binds to host complement regulators; mediates leukocyte adhesion and migration; immunogenic in mouse; produced at ambient pH
orf19.3112ZRT1Candida albicans SC5314Putative zinc transporter; acts with Pra1 in sequestration of zinc from host tissues during infection; hyphal, macrophage-induced; alkaline induced upon adherence to polystyrene; induced in oralpharyngeal candidasis; Spider biofilm induced
orf19.3113Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.6457Candida albicans SC5314Protein of unknown function
orf19.6459DPP3Candida albicans SC5314Protein similar to S. cerevisiae pyrophosphate phosphatase Dpp1; required for farnesol biosynthesis; repressed by 17-beta-estradiol, ethynyl estradiol; Spider biofilm induced
orf19.3116EXM2Candida albicans SC5314Putative U1 snRNP complex compotent; decreased transcription is observed upon fluphenazine treatment
orf19.5801RNR21Candida albicans SC5314Ribonucleoside-diphosphate reductase; regulated by tyrosol and cell density; ciclopirox olamine, fluconazole or flucytosine induced; regulated by Sef1, Sfu1, and Hap43
orf19.5802Candida albicans SC5314Protein of unknown function
orf19.5804HYU1Candida albicans SC5314Putative hydantoin utilization protein A; induced upon adherence to polystyrene; regulated by Gcn2p and Gcn4p
orf19.5805DLD1Candida albicans SC5314Putative D-lactate dehydrogenase; white cell-specific trancript; colony morphology-related gene regulation by Ssn6; Hap43-repressed; rat catheter biofilm induced; Spider biofilm repressed
orf19.5806ALD5Candida albicans SC5314NAD-aldehyde dehydrogenase; decreased expression in fluconazole-resistant isolate, or in hyphae; biofilm induced; fluconazole-downregulated; protein abundance is affected by URA3 expression in the CAI-4 strain; stationary phase enriched
orf19.3122ARR3Candida albicans SC5314Ortholog of S. cerevisiae Arr3; arsenite transporter of the plasma membrane required for resistance to arsenic compounds; benomyl-induced; Gcn4-regulated; Hap43-repressed; mutant is viable; Spider biofilm induced
orf19.3123RPT5Candida albicans SC531426S proteasome regulatory subunit; transcript regulated by Nrg1 and Mig1; regulated by Gcn2 and Gcn4; protein level decreases in stationary phase
orf19.6469Candida albicans SC5314Predicted ORF in retrotransposon Tca11 with similarity to the Gag-Pol region of retrotransposons, which encodes nucleocapsid-like protein, reverse transcriptase, protease, and integrase
orf19.3126CCT6Candida albicans SC5314Putative cytosolic chaperonin Cct ring complex subunit; mutation confers hypersensitivity to cytochalasin D; GlcNAc-induced protein; Spider biofilm repressed
orf19.6590VMA22Candida albicans SC5314Protein of unknown function
orf19.1237ARO9Candida albicans SC5314Aromatic transaminase; Ehrlich fusel oil pathway of aromatic alcohol biosynthesis; Rim101-dependent pH-regulation (alkaline induced); Hap43-induced gene
Locus IdGene NameOrganismDescription
orf19.7121Candida albicans SC5314Protein of unknown function; Spider biofilm repressed
orf19.7124RVS161Candida albicans SC5314Protein required for endocytosis; contains a BAR domain, which is found in proteins involved in membrane curvature; null mutant exhibits defects in hyphal growth, virulence, cell wall integrity, and actin patch localization
orf19.7125Candida albicans SC5314Protein of unknown function; Spider biofilm repressed
orf19.881DFG16Candida albicans SC5314Rim101 pathway protein that acts in Rim101 processing; regulates filamentation in response to alkaline pH; required for host tissue invasion during infection; flow model biofilm induced
orf19.7127TLO16Candida albicans SC5314Member of a family of telomere-proximal genes of unknown function; may be spliced in vivo
orf19.7128SYS1Candida albicans SC5314Putative Golgi integral membrane protein; transcript regulated by Mig1
orf19.3920Candida albicans SC5314Protein of unknown function
orf19.3923PGA37Candida albicans SC5314Putative GPI-anchored protein; Hap43-repressed; Spider biofilm induced
orf19.886PAN1Candida albicans SC5314Essential protein involved in endocytosis and polarized growth; ortholog of S. cerevisiae Pan1, which is a part of a complex that regulates actin cytoskeleton; Spider biofilm repressed
orf19.3924Candida albicans SC5314Protein of unknown function
orf19.3926RNY11Candida albicans SC5314Protein of unknown function
orf19.889THI20Candida albicans SC5314Putative trifunctional enzyme of thiamine biosynthesis, degradation and salvage; Spider biofilm induced
orf19.1240Candida albicans SC5314Protein of unknown function
orf19.4585TFG1Candida albicans SC5314Protein similar to S. cerevisiae Tfg1p, which is part of transcription factor TFIIF; transposon mutation affects filamentous growth; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.4587HGH1Candida albicans SC5314Putative HMG1/2-related protein; transcript regulated by Mig1
orf19.4589Candida albicans SC5314Protein of unknown function
orf19.1248Candida albicans SC5314Putative RNA polymerase II subunit B44; heterozygous null mutant exhibits resistance to parnafungin in the C. albicans fitness test; Spider biofilm repressed
orf19.7130Candida albicans SC5314Protein of unknown function; Hap43-repressed gene
orf19.7131Candida albicans SC5314Butyrobetaine dioxygenase, the fourth enzyme of the carnitine biosynthesis pathway
orf19.7136SPT6Candida albicans SC5314Putative transcription elongation factor; transposon mutation affects filamentous growth; transcript induced in an RHE model of oral candidiasis and in clinical isolates from oral candidiasis
Locus IdGene NameOrganismDescription
orf19.891Candida albicans SC5314Putative AMP deaminase; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.3930YUH2Candida albicans SC5314Putative ubiquitin C-terminal hydrolase; sumoylation target
orf19.5216Candida albicans SC5314Protein of unknown function
orf19.5217TES1Candida albicans SC5314Putative acyl-CoA thioesterase
orf19.5219IRA2Candida albicans SC5314GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form; Spider biofilm induced; flow model biofilm repressed
orf19.2672NCP1Candida albicans SC5314NADPH-cytochrome P450 reductase, acts with Erg11p in sterol 14 alpha-demethylation in ergosterol biosynthesis; subject to hypoxic regulation; ketoconazole-induced; caspofungin repressed
orf19.2678BUB1Candida albicans SC5314Putative cell cycle checkpoint kinase; mutation confers increased sensitivity to nocodazole
orf19.5220Candida albicans SC5314Putative RNA exonuclease; induced in a ssr1 null mutant
orf19.5223Candida albicans SC5314Protein of unknown function
orf19.5225Candida albicans SC5314Protein of unknown function
orf19.5226WRS1Candida albicans SC5314Putative tRNA-Trp synthetase; genes encoding ribosomal subunits, translation factors, tRNA synthetases are downregulated upon phagocytosis by murine macrophages
orf19.5228RIB3Candida albicans SC53143,4-Dihydroxy-2-butanone 4-phosphate synthase; homodimeric enzyme of riboflavin biosynthesis; converts ribulose 5-phosphate to L-3,4-dihydroxy-2-butanone 4-phosphate; transcription regulated on yeast-hyphal switch, macrophage interaction
orf19.5229Candida albicans SC5314Protein of unknown function
orf19.2681RBT7Candida albicans SC5314Protein with similarity to RNase T2 enzymes; has putative secretion signal; expression is Tup1-repressed
orf19.2684Candida albicans SC5314Protein of unknown function; flow model biofilm repressed
orf19.2688NAN1Candida albicans SC5314Putative U3 snoRNP protein; Hap43p-induced gene; physically interacts with TAP-tagged Nop1p
orf19.5231Candida albicans SC5314Protein of unknown function; flow model biofilm induced
orf19.5232CSI2Candida albicans SC5314Putative 66S pre-ribosomal particle component; Hap43-induced; essential for growth; transposon mutation affects filamentous growth; Spider biofilm induced
orf19.5234RBD1Candida albicans SC5314Rhomboid-like protein; similar to putative intramembrane serine proteases; role in filamentous growth; Gcn4-regulated; caspofungin repressed; Spider biofilm induced
orf19.5236Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.5237VPH2Candida albicans SC5314Protein of unknown function
orf19.5239Candida albicans SC5314Predicted alanine-tRNA ligase; oxidative stress-induced via Cap1
orf19.2691Candida albicans SC5314Planktonic growth-induced gene
orf19.5013AGM1Candida albicans SC5314Phosphoacetylglucosamine mutase (N-acetylglucosamine-phosphate mutase); enzyme of UDP-N-acetylglucosamine (UDP-GlcNAc) biosynthesis
orf19.5014Candida albicans SC5314Protein of unknown function
orf19.5019Candida albicans SC5314Protein of unknown function
orf19.1814STT4Candida albicans SC5314Putative phosphatidylinositol-4-kinase
orf19.2471GIM5Candida albicans SC5314Putative heterohexameric cochaperone prefoldin complex subunit; macrophage/pseudohyphal-repressed gene and macrophage-induced protein
orf19.2472Candida albicans SC5314Ortholog of S. pombe replication termination factor Rtf2; Spider biofilm induced
orf19.2473Candida albicans SC5314Putative RSC chromatin remodeling complex component; decreased transcription is observed upon fluphenazine treatment or in an azole-resistant strain that overexpresses CDR1 and CDR2
orf19.2478Candida albicans SC5314Protein of unknown function
orf19.5020Candida albicans SC5314Protein of unknown function; Hap43-induced; Spider biofilm induced
orf19.5022Candida albicans SC5314Protein of unknown function
orf19.5023DAL7Candida albicans SC5314Putative allantoate permease; mutant is viable
orf19.5025MET3Candida albicans SC5314ATP sulfurlyase; sulfate assimilation; repressed by Met, Cys, Sfu1, or in fluconazole-resistant isolate; Hog1, caspofungin, white phase-induced; induced on biofilm formation, even in presence of Met and Cys; Spider, F-12/CO2 biofilm induced
orf19.5027LCB2Candida albicans SC5314Putative serine palmitoyltransferase component; mutation confers hypersensitivity to aureobasidin A
orf19.1824PGA50Candida albicans SC5314Putative GPI-anchored protein; adhesin-like protein
orf19.2483RIM1Candida albicans SC5314Putative single-stranded DNA-binding protein; protein level decreases in stationary phase cultures; rat catheter biofilm repressed
orf19.1827Candida albicans SC5314Protein of unknown function; flow model biofilm induced; induced by alpha pheromone in SpiderM medium
orf19.1828BUD16Candida albicans SC5314Putative pyridoxal kinase; a key enzyme in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; involved in bud-site selection and genome integrity in S. cerevisiae; induced by alpha pheromone in SpiderM medium
Locus IdGene NameOrganismDescription
orf19.2487Candida albicans SC5314Protein with a predicted phosphoribulokinase/uridine kinase domain; Spider biofilm induced
orf19.2489Candida albicans SC5314Putative karyopherin beta; repressed by nitric oxide
orf19.5031SSK1Candida albicans SC5314Response regulator of two-component system; role in oxidative stress response, cell wall biosynthesis, virulence, hyphal growth on solid media; expressed in hyphae and yeast; peroxisomal targeting sequence (PTS1); Spider biofilm induced
orf19.5033Candida albicans SC5314Protein of unknown function
orf19.5038Candida albicans SC5314Predicted tRNA (guanine) methyltransferase activity; Spider biofilm induced
orf19.1830Candida albicans SC5314Protein of unknown function; Hap43-induced; rat catheter and Spider biofilm induced
orf19.1831Candida albicans SC5314Dubious open reading frame
orf19.1832FCY23Candida albicans SC5314Putative transporter; Gcn4p-regulated; more similar to S. cerevisiae Tpn1p, which is a vitamin B6 transporter, than to purine-cytosine permeases
orf19.5811MET1Candida albicans SC5314Putative uroporphyrin-3 C-methyltransferase, methionine biosynthesis enzyme; upregulated by human whole blood or polymorphonuclear (PMN) cells; Hog1p-induced; fungal-specific (no human or murine homolog); Hap43p-repressed
orf19.5813Candida albicans SC5314Putative adhesin-like protein; upregulated during growth in the mouse cecum; flow model, rat catheter and Spider biofilm induced
orf19.6470AHP2Candida albicans SC5314Putative thiol-specific peroxiredoxin; macrophage-downregulated gene
orf19.5815SCT2Candida albicans SC5314Putative glycerol-3-phosphate acyltransferase; fungal-specific (no human or murine homolog)
orf19.5816EBP7Candida albicans SC5314Putative NADPH oxidoreductase; mutation confers hypersensitivity to toxic ergosterol analog; oxidative stress-induced via Cap1p
orf19.5817Candida albicans SC5314Protein of unknown function
orf19.6474Candida albicans SC5314Protein with chitin synthesis regulation, resistance to Congo red domain; membrane-localized protein; Spider biofilm induced
orf19.3132Candida albicans SC5314Predicted endoplasmic reticulum zinc transporter; induced by nitric oxide
orf19.3133GUT2Candida albicans SC5314Glycerol-3-phosphate dehydrogenase; Plc1p-regulated; rat catheter biofilm induced; Spider biofilm induced
orf19.3134Candida albicans SC5314Protein of unknown function; flow model biofilm induced
orf19.6478YCF1Candida albicans SC5314Putative glutathione S-conjugate transporter; MRP/CFTR-subfamily, ABC type transporter; human neutrophil-induced; oxidative stress-induced via Cap1; possible association with multidrug resistance; possibly essential; Spider biofilm induced
orf19.3135Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.6479SEC1Candida albicans SC5314Protein of unknown function
orf19.3136Candida albicans SC5314Protein of unknown function
orf19.3138NOP1Candida albicans SC5314Nucleolar protein; flucytosine induced; Hap43-induced; Spider biofilm repressed
orf19.5820UGA6Candida albicans SC5314Putative GABA-specific permease; decreased transcription is observed upon benomyl treatment or in an azole-resistant strain that overexpresses MDR1
orf19.5821Candida albicans SC5314Protein of unknown function
orf19.5823SGT2Candida albicans SC5314Putative small tetratricopeptide repeat (TPR)-containing protein; protein abundance is affected by URA3 expression in the CAI-4 strain background; Mig1-regulated
orf19.6480Candida albicans SC5314Protein of unknown function
orf19.5824Candida albicans SC5314Protein of unknown function; rat catheter and Spider biofilm induced
orf19.6481YPS7Candida albicans SC5314Putative aspartic-type endopeptidase with limited ability to degrade alpha pheromone; mutants show increased sensitivity to alpha pheromone
orf19.5827BUB2Candida albicans SC5314Protein of unknown function
orf19.893PGA17Candida albicans SC5314Putative GPI-anchored protein; exogenously expressed protein substrate for Kex2 processing in vitro; repressed by alpha pheromone in SpiderM medium; macrophage-induced; induced in oralpharyngeal candidiasis; Spider biofilm induced
orf19.7139Candida albicans SC5314Protein of unknown function
orf19.3931SFC1Candida albicans SC5314Putative succinate-fumarate transporter; involved in repression of growth on sorbose; alkaline induced; rat catheter biofilm induced; Spider biofilm induced
orf19.894Candida albicans SC5314Protein of unknown function
orf19.895HOG1Candida albicans SC5314MAP kinase of osmotic-, heavy metal-, and core stress response; role in regulation of glycerol, D-arabitol in response to stress; phosphorylated in response to H2O2 (Ssk1-dependent) or NaCl; mutant induces protective mouse immune response
orf19.896CHK1Candida albicans SC5314Histidine kinase; 2-component signaling, cell wall synthesis; hyphal growth defect; avirulent in mouse, not rat vaginal infection; phagocytosis rate increased; Spider biofilm induced; required for RPMI biofilm; Bcr1-induced in a/a biofilm
orf19.3934CAR1Candida albicans SC5314Arginase; arginine catabolism; transcript regulated by Nrg1, Mig1, Tup1; colony morphology-related regulation by Ssn6; alkaline induced; protein decreased in stationary phase; sumoylation target; flow model biofilm induced
orf19.897VPS20Candida albicans SC5314ESCRT III complex protein; role in multivesicular body (MVB) trafficking; required for processing of Rim8; Bcr1-repressed in RPMI a/a biofilms
orf19.4591CAT2Candida albicans SC5314Major carnitine acetyl transferase; intracellular acetyl-CoA transport; localized in peroxisomes and mitochondria; induced in macrophages; Hog1-repressed; stationary phase enriched; farnesol-upregulated in biofilm; Spider biofilm induced
orf19.898HEM2Candida albicans SC5314Putative porphobilinogen synthase; induced in high iron; protein level decrease in stationary phase cultures; Spider biofilm repressed
Locus IdGene NameOrganismDescription
orf19.4592HSX11Candida albicans SC5314UDP-glucose:ceramide glucosyltransferase (glucosylceramide synthase [GCS], EC 2.4.1.80); involved in glucosylceramide biosynthesis, which is important for virulence
orf19.1250Candida albicans SC5314Protein of unknown function
orf19.4594CLC1Candida albicans SC5314Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; rat cathetr and Spider biofilm repressed
orf19.1251BRN1Candida albicans SC5314Putative condensin complex subunit; cell-cycle regulated periodic mRNA expression
orf19.3939Candida albicans SC5314Protein of unknown function
orf19.4596Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.1253PHO4Candida albicans SC5314bHLH transcription factor of the myc-family; required for growth in medium lacking phosphate and for resistance to copper and Phloxine B; induced by Mnl1 under weak acid stress
orf19.1254SEC23Candida albicans SC5314Putative GTPase-activating protein; regulated upon yeast-hypha switch; Spider biofilm repressed
orf19.1258Candida albicans SC5314Adhesin-like protein; regulated by Tsa1, Tsa1B in minimal media at 37 deg; clade-associated gene expression; induced by alpha pheromone in SpiderM medium; Hap43-induced; Spider biofilm repressed
orf19.100Candida albicans SC5314Alpha/beta hydrolase and lipase domain protein; Hap43-repressed; Spider and flow model biofilm induced
orf19.2694TYS1Candida albicans SC5314Putative tRNA-Tyr synthetase; downregulated upon phagocytosis by murine macrophages; stationary phase enriched protein; Spider biofilm repressed
orf19.2695UBR1Candida albicans SC5314Protein similar to S. cerevisiae Ubr1p ubiquitin-protein ligase; transposon mutation affects filamentous growth; Spider biofilm induced
orf19.2697Candida albicans SC5314Protein of unknown function
orf19.2699ABP1Candida albicans SC5314Ortholog of S. cerevisiae Abp1; actin-binding protein of the cortical actin cytoskeleton; caspofungin induced; protein only detected in stationary phase yeast-form cultures; Spider biofilm repressed
orf19.5242CDC6Candida albicans SC5314Putative ATP-binding protein with a predicted role in DNA replication; member of conserved Mcm1p regulon; periodic mRNA expression, peak at cell-cycle M/G1 phase
orf19.5243TRP3Candida albicans SC5314Putative bifunctional enzyme with predicted indole-3-glycerol-phosphate synthase and anthranilate synthase activities; regulated by Gcn2p and Gcn4p
orf19.5244MCD4Candida albicans SC5314Protein of major facilitator superfamily; has phosphodiesterase/nucleotide pyrophosphatase domain; similar to S. cerevisiae Mcd4p, which acts in GPI anchor biosynthesis; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.5245BUL4Candida albicans SC5314Protein with a predicted BUL1 N-terminal and C-terminal domains; Bul1 binds the ubiquitin ligase Rsp5 in S. cerevisiae; Hap43-repressed gene; rat catheter biofilm induced
orf19.5246Candida albicans SC5314Protein of unknown function; Hap43-repressed gene
orf19.5247Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.5248MSO1Candida albicans SC5314Putative secretory protein involved in S. cerevisiae sporulation; repressed during pseudohyphal growth in the presence of lysed macrophages; Hap43-repressed; Spider biofilm induced
orf19.5249Candida albicans SC5314Protein of unknown function
orf19.5251ZCF30Candida albicans SC5314Predicted Zn(II)2Cys6 transcription factor; mutants are viable; repressed by fluphenazine; Spider biofilm induced
orf19.5253Candida albicans SC5314Protein of unknown function
orf19.5255PXA2Candida albicans SC5314Putative peroxisomal, half-size adrenoleukodystrophy protein (ALD or ALDp) subfamily ABC transporter; Gcn4p-regulated
orf19.5256Candida albicans SC5314Protein of unknown function; Hap43-repressed gene; induced by alpha pheromone in SpiderM medium
orf19.5258Candida albicans SC5314Protein of unknown function; induced by nitric oxide
orf19.900NSP1Candida albicans SC5314Essential component of the nuclear pore complex; sumoylation target; stationary phase enriched protein; rat catheter biofilm repressed
orf19.903GPM1Candida albicans SC5314Phosphoglycerate mutase; surface protein that binds host complement Factor H and FHL-1; antigenic; fluconazole, or amino acid starvation (3-AT) induced, farnesol-repressed; Hap43, flow model biofilm induced; Spider biofilm repressed
orf19.4601Candida albicans SC5314Putative RNA polymerase III transcription initiation factor complex (TFIIIC) subunit; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.4602MDH1-1Candida albicans SC5314Predicted malate dehydrogenase precursor; macrophage-induced transcript; protein present in exponential and stationary growth phase yeast cultures; Spider biofilm repressed
orf19.1834Candida albicans SC5314Protein of unknown function
orf19.1835PEA2Candida albicans SC5314Putative coiled-coil polarisome; predicted role in polarized morphogenesis, cell fusion, and low affinity Ca2+ influx; rat catheter biofilm induced
orf19.1836APN2Candida albicans SC5314Putative class II abasic (AP) endonuclease; flucytosine induced
orf19.2494Candida albicans SC5314Protein of unknown function
orf19.2495GSL1Candida albicans SC5314Beta-1,3-glucan synthase subunit; 10 predicted transmembrane regions; caspofungin induced; repressed by yeast-to-hypha transition; young biofilm repressed, induced by biofilm drug exposure; Bcr1-repressed in RPMI a/a biofilms
orf19.1839RPA190Candida albicans SC5314Putative RNA polymerase I subunit A190; Hap43p-induced gene; flucytosine induced
orf19.5040Candida albicans SC5314Protein of unknown function
orf19.5041Candida albicans SC5314Protein of unknown function
orf19.5043Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.5046RAM1Candida albicans SC5314Protein that acts in prenylation; transcription is alpha-factor induced; regulated in response to lovastatin and fluconazole; Hap43p-repressed gene
orf19.5049Candida albicans SC5314Putative U3-containing 90S preribosome processome complex subunit; Hap43-induced gene; rat catheter and Spider biofilm induced; F-12/CO2 early biofilm induced
orf19.1841Candida albicans SC5314Protein of unknown function; Hap43-induced gene
orf19.1843ALG6Candida albicans SC5314Putative glucosyltransferase involved in cell wall mannan biosynthesis; transcription is elevated in chk1, nik1, and sln1 homozygous null mutants; repressed by nitric oxide; possibly essential gene, disruptants not obtained by UAU1 method
orf19.1847ARO10Candida albicans SC5314Aromatic decarboxylase; Ehrlich fusel oil pathway of aromatic alcohol biosynthesis; alkaline repressed; protein abundance affected by URA3 expression in CAI-4 strain; Spider biofilm induced
orf19.5050MTO1Candida albicans SC5314Putative mitochondrial protein; rat catheter biofilm induced
orf19.5051Candida albicans SC5314Protein of unknown function
orf19.5053Candida albicans SC5314Protein of unknown function
orf19.1850SIW14Candida albicans SC5314Putative protein phosphatase of the PTP family (tyrosine-specific), similar to S. cerevisiae Siw14p; mutant shows virulence defect; Hap43p-repressed gene
orf19.1852Candida albicans SC5314Protein of unknown function
orf19.1853HHT2Candida albicans SC5314Putative histone H3; farnesol regulated; Hap43-induced; rat catheter and Spider biofilm repressed
orf19.1855Candida albicans SC5314Predicted membrane transporter, member of the anion:cation symporter (ACS) family, major facilitator superfamily (MFS); Gcn4p-regulated; flucytosine induced; ketoconazole-repressed; oxidative stress-induced via Cap1p
orf19.3140Candida albicans SC5314Protein of unknown function
orf19.3141Candida albicans SC5314Protein of unknown function
orf19.6486LDG3Candida albicans SC5314Putative LDG family protein; F-12/CO2 early biofilm induced
orf19.6487Candida albicans SC5314Protein of unknown function
orf19.6489FMP45Candida albicans SC5314Predicted membrane protein induced during mating; mutation confers hypersensitivity to toxic ergosterol analog, to amphotericin B; alkaline repressed; repressed by alpha pheromone in SpiderM medium; rat catheter, Spider biofilm induced
orf19.3148Candida albicans SC5314Protein of unknown function; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.5830LHS1Candida albicans SC5314Protein similar to S. cerevisiae Hsp70p; predicted Kex2p substrate; possibly essential, disruptants not obtained by UAU1 method; flow model biofilm repressed
orf19.5831Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.5833Candida albicans SC5314Protein of unknown function
orf19.6491Candida albicans SC5314Protein of unknown function
orf19.6492Candida albicans SC5314Predicted protein serine/threonine kinase and/or protein tyrosine kinase; Spider biofilm induced
orf19.6493Candida albicans SC5314Protein of unknown function
orf19.3150GRE2Candida albicans SC5314Putative reductase; Nrg1 and Tup1-regulated; benomyl- and hyphal-induced; macrophage/pseudohyphal-repressed; repressed by low iron; possibly involved in osmotic stress response; stationary phase enriched protein; Spider biofilm induced
orf19.5838SER2Candida albicans SC5314Protein of unknown function
orf19.3151Candida albicans SC5314Protein of unknown function
orf19.3152AMO2Candida albicans SC5314Protein similar to A. niger predicted peroxisomal copper amino oxidase; mutation confers hypersensitivity to toxic ergosterol analog; F-12/CO2 early biofilm induced
orf19.3153MSS4Candida albicans SC5314Phosphatidylinositol-4-phosphate 5-kinase; activity induced by phosphatidic acid (Pld1 product); macrophage/pseudohyphal-repressed; mRNA binds to She3, localized to yeast cell buds and hyphal tips; Hap43-induced; Spider biofilm induced
orf19.3154Candida albicans SC5314Protein of unknown function
orf19.6499Candida albicans SC5314Predicted DNA-directed RNA polymerase; role in transcription; Spider biofilm induced
orf19.3158Candida albicans SC5314Protein of unknown function
orf19.3159UTP20Candida albicans SC5314Putative snoRNA-binding protein; S. cerevisiae Utp20 ortholog; likely essential for growth; repressed in core stress response; mutation confers resistance to 5-fluorocytosine (5-FC) and parnafungin
orf19.2500Candida albicans SC5314Protein of unknown function
orf19.101RIM9Candida albicans SC5314Protein required for alkaline pH response via the Rim101 signaling pathway; ortholog of S. cerevisiae Rim9 and A. nidulans palI; Spider biofilm induced
orf19.103KAR5Candida albicans SC5314Ortholog of S. cerevisiae Kar5; involved in nuclear membrane fusion during karyogamy; induced by alpha factor
orf19.104Candida albicans SC5314Protein of unknown function; induced by alpha pheromone in SpiderM medium
orf19.105HAL22Candida albicans SC5314Putative phosphoadenosine-5'-phosphate or 3'-phosphoadenosine 5'-phosphosulfate phosphatase; possible role in sulfur recycling; Hap43-repressed; F-12/CO2 biofilm induced
orf19.7141UFE1Candida albicans SC5314Protein interacting with Sec20p, possibly involved in retrograde transport between the Golgi and the endoplasmic reticulum; functional homolog of S. cerevisiae Ufe1p, which is an ER t-SNARE that mediates the retrograde traffic
orf19.7144Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.7148TPO2Candida albicans SC5314Putative polyamine transport protein; fungal-specific (no human or murine homolog)
orf19.7149Candida albicans SC5314Putative GTPase inhibitor; predicted role in endocytosis, protein targeting to vacuole; rat catheter biofilm repressed
orf19.3941URA7Candida albicans SC5314CTP synthase 1; flucytosine induced; protein present in exponential and stationary growth phase yeast cultures
orf19.3944GRR1Candida albicans SC5314F-box protein component of the SCF ubiquitin-ligase complex required for cell cycle progression; involved in negative control of pseudohyphal growth; Spider biofilm induced
orf19.3945Candida albicans SC5314Predicted COP9 signalosome complex subunit 12; flow model biofilm induced
orf19.1261CGT1Candida albicans SC5314mRNA 5' guanylyltransferase; small subunit of mRNA capping enzyme; binds an RNA Pol II C-terminal domain peptide; Cet1p and Cgt1p form a 2:1 complex; functional homolog of S. cerevisiae Ceg1p
orf19.1264CFL2Candida albicans SC5314Oxidoreductase; iron utilization; Sfu1/Sef1/Hap43/Nrg1/Tup1/Rim101 regulated; alkaline/low iron/fluphenazine/ciclopirox olamine, flucytosine, fluconazole, Spider/flow model/rat catheter biofilm induced; caspofungin/amphotericin B repressed
orf19.1266Candida albicans SC5314Protein of unknown function; transcript detected on high-resolution tiling arrays
orf19.1268Candida albicans SC5314Protein of unknown function; transcript detected on high-resolution tiling arrays; rat catheter biofilm induced
orf19.111CAN2Candida albicans SC5314Basic amino acid permease; arginine metabolism; regulated by Nrg1/Tup1; caspofungin, flucytosine induced; colony morphology-related regulation by Ssn6; Hap43-repressed; rat catheter and Spider biofilm induced; promoter bound by Efg1
orf19.114Candida albicans SC5314Protein of unknown function
orf19.7150NRG1Candida albicans SC5314Transcription factor/repressor; regulates chlamydospore formation/hyphal gene induction/virulence and rescue/stress response genes; effects both Tup1 dependent and independent regulation; flow model biofilm induced; Spider biofilm repressed
orf19.7151Candida albicans SC5314Protein of unknown function
orf19.4603ARL1Candida albicans SC5314Putative GTPase; mutation confers dose-dependent sensitivity to Brefeldin A
orf19.5262Candida albicans SC5314Protein of unknown function
orf19.4606ERG8Candida albicans SC5314Putative phosphomevalonate kinase; enzyme of the mevalonate pathway of isoprenoid biosynthesis; transcript regulated by Nrg1; possible drug target; not conserved in H. sapiens
orf19.4607Candida albicans SC5314Possible Golgi membrane protein; Hap43-repressed; hypha induced; flow model biofilm induced; Spider biofilm induced
orf19.4608PDC12Candida albicans SC5314Putative pyruvate decarboxylase; fungal-specific (no human or murine homolog)
orf19.4609Candida albicans SC5314Putative dienelactone hydrolase; protein abundance is affected by URA3 expression in the CAI-4 strain background; protein present in exponential and stationary growth phase yeast cultures; rat catheter biofilm repressed
orf19.5266Candida albicans SC5314Planktonic growth-induced gene
Locus IdGene NameOrganismDescription
orf19.5268MED10Candida albicans SC5314RNA polymerase II mediator complex subunit; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.910PRP3Candida albicans SC5314Predicted splicing factor, component of the U4/U6-U5 snRNP complex; Hap43-induced gene; rat catheter biofilm induced
orf19.915Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.4610Candida albicans SC5314Predicted metallocarboxypeptidase; role in proteolysis; rat catheter biofilm repressed
orf19.4611Candida albicans SC5314Protein of unknown function
orf19.5270Candida albicans SC5314Protein of unknown function; rat catheter biofilm induced
orf19.5271Candida albicans SC5314Protein of unknown function; Hap43-induced gene
orf19.4616POL30Candida albicans SC5314Similar to proliferating cell nuclear antigen (PCNA); RNA abundance regulated by tyrosol, cell density; induced by flucytosine, interaction with macrophages; stationary phase enriched protein; rat catheter and Spider biofilm repressed
orf19.4617Candida albicans SC5314Predicted peptide alpha-N-acetyltransferase; flow model biofilm induced
orf19.4618FBA1Candida albicans SC5314Fructose-bisphosphate aldolase; glycolytic enzyme; antigenic in murine/human infection; regulated by yeast-hypha switch; induced by Efg1, Gcn4, Hog1, fluconazole; phagocytosis-repressed; flow model biofilm induced; Spider biofilm repressed
orf19.5276Candida albicans SC5314Putative nuclear pore-associated protein; Hap43p-induced gene; induced upon low-level peroxide stress; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.5278Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.921HMS1Candida albicans SC5314hLh domain Myc-type transcript factor; required for morphogenesis induced by elevated temperature or Hsp90 compromise; acts downstream of Pcl1; Spider biofilm induced
orf19.923THR1Candida albicans SC5314Putative homoserine kinase; regulated by Tup1; amphotericin B repressed; regulated by Gcn2 and Gcn4; Spider biofilm repressed
orf19.926EXO1Candida albicans SC5314Putative exodeoxyribonuclease; cell-cycle regulated periodic mRNA expression
orf19.1857Candida albicans SC5314Putative L-azetidine-2-carboxylic acid acetyltransferase; mutants are viable
orf19.702Candida albicans SC5314Protein of unknown function
orf19.704SOL3Candida albicans SC5314Putative 6-phosphogluconolactonase; present in exponential and stationary growth phase yeast cultures; macrophage-downregulated protein; Spider biofilm repressed
orf19.706NMD3Candida albicans SC5314Putative nonsense-mediated mRNA decay protein; repressed in core stress response; repressed by prostaglandins
orf19.707APG7Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.708Candida albicans SC5314Protein of unknown function
orf19.709PUP2Candida albicans SC5314Alpha5 subunit of the 20S proteasome; macrophage/pseudohyphal-repressed; regulated by Gcn2p and Gcn4p; protein present in exponential and stationary growth phase yeast cultures
orf19.5061ADE5,7Candida albicans SC5314Phosphoribosylamine-glycine ligase and phosphoribosylformylglycinamidine cyclo-ligase; interacts with Vps34p; required for hyphal growth and virulence; flucytosine induced; not induced in GCN response, in contrast to S. cerevisiae ortholog
orf19.4406NIF3Candida albicans SC5314Protein of unknown function; ortholog of S. cerevisiae Nif3; rat catheter biofilm repressed
orf19.5064MRPL3Candida albicans SC5314Ribosomal protein of the large subunit, mitochondrial; repressed in core stress response; protein present in exponential and stationary growth phase yeast cultures
orf19.4409Candida albicans SC5314Protein of unknown function
orf19.5068IRE1Candida albicans SC5314Putative protein kinase; role in cell wall regulation; mutant is hypersensitive to caspofungin; Spider biofilm induced
orf19.5069Candida albicans SC5314Ortholog of S. cerevisiae Sae3; meiosis specific protein involved in DMC1-dependent meiotic recombination in S. cerevisiae; Spider biofilm induced
orf19.1862Candida albicans SC5314Possible stress protein; increased transcription associated with CDR1 and CDR2 overexpression or fluphenazine treatment; regulated by Sfu1, Nrg1, Tup1; stationary phase enriched protein; Spider biofilm induced
orf19.1863Candida albicans SC5314Protein of unknown function
orf19.1865MCS7Candida albicans SC5314S. cerevisiae ortholog Mcs7 has a role in reciprocal meiotic recombination; Spider biofilm repressed
orf19.1867Candida albicans SC5314Putative malate permease; induced during macrophage infection; regulated by Gcn2 and Gcn4; putative peroxisome targeting signal; Hap43-repressed; Spider biofilm induced
orf19.1868RNR22Candida albicans SC5314Putative ribonucleoside diphosphate reductase;colony morphology-related gene regulation by Ssn6; transcript regulated by tyrosol and cell density; Hap43-repressed; Spider biofilm induced
orf19.712KIP1Candida albicans SC5314Non-essential kinesin from the bipolar (Kinesis-5) family; involved in formation of the mitotic spindle
orf19.5846Candida albicans SC5314Putative TFIIH and nucleotide excision repair factor 3 complex subunit; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.2503Candida albicans SC5314Protein of unknown function
orf19.5847Candida albicans SC5314Protein of unknown function
orf19.2504BMS1Candida albicans SC5314Putative GTPase; Hap43-induced gene; mutation confers resistance to 5-fluorocytosine (5-FC); flucytosine induced; repressed by prostaglandins; Spider biofilm induced
orf19.5848Candida albicans SC5314RING-type zinc finger protein; upregulated during oral infection; mutants have reduced ability to damage oral epithelial cells; Spider and flow model biofilm induced
orf19.2505Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.2506Candida albicans SC5314Protein of unknown function; opaque-specific transcript; induced during chlamydospore formation in both C. albicans and C. dubliniensis; Hog1-repressed; Spider biofilm induced
orf19.2507ARP9Candida albicans SC5314Protein similar to S. cerevisiae Arp3p, a component of the Arp2/3 complex involved in actin-dependent processes; likely to be essential for growth, based on an insertional mutagenesis strategy
orf19.2508PRM9Candida albicans SC5314Protein described a similar to S. cerevisiae Prm9; not the ortholog though; mutant is viable
orf19.3166Candida albicans SC5314Protein of unknown function
orf19.3168RPN8Candida albicans SC5314Putative regulatory subunit of the 26S proteasome; mutation confers hypersensitivity to amphotericin B; regulated by Mig1, Gcn2 and Gcn4; Spider biofilm repressed
orf19.3169Candida albicans SC5314Protein of unknown function
orf19.5850NOC2Candida albicans SC5314Putative nucleolar complex protein; Hap43-induced; transposon mutation affects filamentous growth; mutation confers hypersensitivity to 5-fluorouracil (5-FU), tubercidin (7-deazaadenosine); repressed in core stress response
orf19.5851STE13Candida albicans SC5314Putative pheromone-processing dipeptidyl aminopeptidase; possible Kex2 substrate; transposon mutation affects filamentous growth; induced by low nitrogen, germ tube formation; flow model biofilm repressed
orf19.5852Candida albicans SC5314Protein of unknown function; rat catheter biofilm repressed
orf19.5854SBP1Candida albicans SC5314Similar to RNA binding proteins; downregulated upon adherence to polystyrene; stationary-phase enriched protein
orf19.5855MBP1Candida albicans SC5314Putative component of the MBF transcription complex involved in G1/S cell-cycle progression; non-periodic mRNA expression; predicted, conserved MBF binding sites upstream of G1/S-regulated genes
orf19.5856Candida albicans SC5314Membrane-localized protein of unknown function
orf19.2513Candida albicans SC5314Protein of unknown function
orf19.3170Candida albicans SC5314Protein of unknown function
orf19.2514Candida albicans SC5314Predicted methyltransferase; rat catheter biofilm induced
orf19.7153Candida albicans SC5314Putative exportin, member of the Exportin-T family; flow model biofilm repressed
orf19.118FAD2Candida albicans SC5314Delta-12 fatty acid desaturase, involved in production of linoleic acid, which is a major component of membranes
orf19.7154UTP18Candida albicans SC5314Putative U3 snoRNA-associated protein; Hap43-induced; repressed in core stress response; physically interacts with TAP-tagged Nop1
orf19.119Candida albicans SC5314Protein of unknown function
orf19.7156FAA2-3Candida albicans SC5314Predicted acyl CoA synthetase
Locus IdGene NameOrganismDescription
orf19.7157Candida albicans SC5314Protein with a tubulin binding cofactor C domain; flow model biofilm induced
orf19.7158Candida albicans SC5314Protein of allantoate permease family; fungal-specific (no human or murine homolog); Hap43p-repressed gene
orf19.3950MSM1Candida albicans SC5314Mitochondrial methionyl-tRNA synthetase (MetRS); functionally complements methionine auxotrophy of an E. coli MetRS mutant; transcript regulated by Nrg1; flow model biofilm induced
orf19.7159Candida albicans SC5314Putative protein of unknown function; Hap43p-repressed gene; ortholog of S. cerevisiae YMR185W
orf19.3951TIP1Candida albicans SC5314Protein with a predicted role in biogenesis of ER-derived COPII transport vesicles; mutation confers hypersensitivity to toxic ergosterol analog
orf19.3952SRP101Candida albicans SC5314Signal recognition particle (SRP) receptor alpha subunit; involved in SRP-dependent protein targeting; rat catheter biofilm repressed
orf19.3954PSD2Candida albicans SC5314Protein of unknown function
orf19.3956Candida albicans SC5314Protein of unknown function
orf19.3957Candida albicans SC5314Protein of unknown function
orf19.1270FRE3Candida albicans SC5314Protein with similarity to ferric reductase Fre10p; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.3959SSD1Candida albicans SC5314Protein with role in resistance to host antimicrobial peptides; virulence role in murine infection; functional homolog of S. cerevisiae Ssd1p, which suppresses various mutant phenotypes; constitutively expressed and not cell-cycle regulated
orf19.1272Candida albicans SC5314Protein of unknown function; may play a role in regulation of cell size; rat catheter biofilm repressed
orf19.1274Candida albicans SC5314Protein of unknown function
orf19.1279CDS1Candida albicans SC5314Protein similar to S. cerevisiae Cds1p; transposon mutation affects filamentous growth
orf19.6500ECM42Candida albicans SC5314Ornithine acetyltransferase; Gcn2, Gcn4-regulated; clade-specific gene expression; possibly essential gene, disruptants not obtained by UAU1 method; Spider biofilm induced
orf19.927Candida albicans SC5314Protein of unknown function
orf19.928Candida albicans SC5314Protein of unknown function
orf19.4621Candida albicans SC5314Protein of unknown function
orf19.929Candida albicans SC5314Protein of unknown function; rat catheter biofilm repressed
orf19.4622Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.5280MUP1Candida albicans SC5314Putative high affinity methionine permease; alkaline upregulated by Rim101; Spider biofilm induced
orf19.4624HRT2Candida albicans SC5314Protein described as having a role in Ty3 transposition; repressed in hyphae; stationary phase enriched protein; rat catheter and Spider biofilm repressed
orf19.5281Candida albicans SC5314Predicted essential RNA-binding G protein; ortholog an effector of mating response pathway in S. cerevisiae; mainly associated with nuclear envelope and ER; flow model and Spider biofilm repressed
orf19.4625TOA2Candida albicans SC5314Putative TFIIA small subunit; protein abundance decreased in CAI4 strain compared to the SC5314 strain, abundance not affected by reintegration of URA3 in CAI4; flucytosine induced; possibly an essential gene (UAU1 method)
orf19.4626Candida albicans SC5314Protein of unknown function
orf19.4627Candida albicans SC5314Protein of unknown function
orf19.4628Candida albicans SC5314Putative cleavage and polyadenylation factor; heterozygous null mutant exhibits hypersensitivity to parnafungin and cordycepin in the C. albicans fitness test; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.5285PST3Candida albicans SC5314Putative flavodoxin; YNB biofilm induced; stationary phase enriched protein; rat catheter and Spider biofilm repressed
orf19.5286YCP4Candida albicans SC5314Putative flavodoxin; flow model, rat catheter and Spider biofilm repressed
orf19.5287Candida albicans SC5314Protein of unknown function
orf19.5288IFE2Candida albicans SC5314Putative alcohol dehydrogenase; yeast-enriched transcript; Efg1-regulated; induced by prostaglandins, Hog1, fluconazole; rat catheter biofilm induced
orf19.930PET9Candida albicans SC5314Mitochondrial ADP/ATP carrier protein involved in ATP biosynthesis; possible lipid raft component; 3 predicted transmembrane helices; flucytosine induced; ketoconazole-induced; downregulated by Efg1p
orf19.932Candida albicans SC5314Putative aminophospholipid translocase (flippase); merged with orf19.2226 in Assembly 21; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.935AGA1Candida albicans SC5314Protein with some similarity to agglutinin subunit; expression regulated upon white-opaque switch; Spider biofilm induced
orf19.937Candida albicans SC5314Protein of unknown function
orf19.4631ERG251Candida albicans SC5314C-4 sterol methyl oxidase; role in ergosterol biosynthesis; Hap43-induced; ketoconazole-induced; amphotericin B, caspofungin repressed; possibly essential gene, disruptants not obtained by UAU1 method; Spider biofilm repressed
orf19.4632RPL20BCandida albicans SC5314Ribosomal protein L20; repressed upon phagocytosis by murine macrophage; alternatively spliced intron in 5' UTR; Hap43-induced; Spider biofilm repressed
orf19.713Candida albicans SC5314Protein of unknown function
orf19.714Candida albicans SC5314Protein of unknown function
orf19.715Candida albicans SC5314Protein of unknown function; Hap43-induced; rat catheter and Spider biofilm induced
Locus IdGene NameOrganismDescription
orf19.717HSP60Candida albicans SC5314Heat shock protein; soluble in hyphae; regulated by Nrg1 and by iron; induced in high iron; heavy metal (cadmium) stress-induced; sumoylation target; protein present in exponential and stationary phase cells; Hap43-repressed
orf19.4410ALG1Candida albicans SC5314Protein similar to S. cerevisiae Alg1p, a mannosyltransferase involved in N-linked protein glycosylation; likely to be essential for growth, based on an insertional mutagenesis strategy
orf19.718RRN11Candida albicans SC5314Putative RNA polymerase I subunit; rat catheter biofilm induced; Spider biofilm induced
orf19.4411HOS1Candida albicans SC5314Histone deacetylase; similar to S. cerevisiae Hos1; has conserved deacetylation motif; slightly greater expression in white cells than in opaque cells
orf19.4412Candida albicans SC5314Protein of unknown function
orf19.719Candida albicans SC5314Protein of unknown function
orf19.4413CMD1Candida albicans SC5314Calmodulin; calmodulin inhibitors cause a defect in hyphal growth; transcript not regulated by yeast-hyphal transition; mutation confers hypersensitivity to cytochalasin D and high concentrations of tunicamycin; gene has intron
orf19.4414Candida albicans SC5314Protein of unknown function
orf19.5071NRP1Candida albicans SC5314Protein of unknown function
orf19.4416VPS13Candida albicans SC5314Putative vacuolar protein sorting-associated protein; gene used for multilocus sequence typing
orf19.5076PFY1Candida albicans SC5314Profilin; functional homolog of S. cerevisiae Pfy1; hyphae, macrophage/pseudohyphal-induced; regulated by Nrg1, Tup1; gene lacks intron (unlike S. cerevisiae PFY1); complements growth of S. cerevisiae srv2 mutant; nonessential
orf19.5077Candida albicans SC5314Protein of unknown function; Hap43-repressed gene; repressed by nitric oxide
orf19.5079CDR4Candida albicans SC5314Putative ABC transporter superfamily; fluconazole, Sfu1, Hog1, core stress response induced; caspofungin repressed; fluconazole resistance not affected by mutation or correlated with expression; rat catheter and flow model biofilm induced
orf19.1872Candida albicans SC5314Plasma membrane protein; repressed by nitric oxide
orf19.1873Candida albicans SC5314Protein of unknown function; Hap43-repressed gene; repressed by nitric oxide
orf19.1877Candida albicans SC5314Protein of unknown function
orf19.1878MED4Candida albicans SC5314RNA polymerase II core mediator complex subunit
orf19.721Candida albicans SC5314Protein of unknown function
orf19.3171ACH1Candida albicans SC5314Acetyl-coA hydrolase; acetate utilization; nonessential; soluble protein in hyphae; antigenic in human; induced on polystyrene adherence; farnesol-, ketoconazole-induced; no human or murine homolog; stationary phase-enriched protein
orf19.5859DAL8Candida albicans SC5314Putative allantoate permease; fungal-specific (no human or murine homolog)
Locus IdGene NameOrganismDescription
orf19.3173Candida albicans SC5314Protein of unknown function
orf19.3174CDC24Candida albicans SC5314GDP-GTP exchange factor for Cdc42p; phosphorylated; required for maintenance of hyphal growth; misexpression blocks hyphal growth and causes avirulence in a mouse model of systemic infection; antigenic during human oral infection
orf19.2518Candida albicans SC5314Protein of unknown function
orf19.2519Candida albicans SC5314Protein of unknown function
orf19.3177Candida albicans SC5314Protein of unknown function
orf19.3178Candida albicans SC5314Protein of unknown function
orf19.5861KRE9Candida albicans SC5314Protein of beta-1,6-glucan biosynthesis; required for serum-induced hyphal growth; required for efficient utilization of galactose and for growth on glucose; similar to S. cerevisiae Kre9p and Knh1p; O-glycosylated by Pmt1p
orf19.5863Candida albicans SC5314Protein of unknown function
orf19.2520Candida albicans SC5314Protein of unknown function
orf19.5866Candida albicans SC5314Protein of unknown function
orf19.3180Candida albicans SC5314Protein of unknown function
orf19.2525LYS12Candida albicans SC5314Homoisocitrate dehydrogenase; catalyzes 4th step in the alpha-aminoadipate pathway of lysine biosynthesis; clade-associated gene expression; protein level decreases in stationary phase cultures; Spider biofilm repressed
orf19.5869Candida albicans SC5314Protein of unknown function
orf19.3184Candida albicans SC5314Protein of unknown function
orf19.2529Candida albicans SC5314Ortholog of S. cerevisiae Gpa15; involved in the synthesis of glycosylphosphatidylinositol (GPI) anchors; shuman Pig-H, which is also involved in GPI assembly; Spider biofilm induced
orf19.3187ZNC1Candida albicans SC5314Zn(2)-Cys(6) transcription factor; regulated by Gcn2 and Gcn4; gene located in zinc cluster region of Chromosome 5, near the MTL locus; required for yeast cell adherence to silicone substrate; Spider biofilm induced
orf19.2530Candida albicans SC5314Dubious open reading frame
orf19.5875VAM3Candida albicans SC5314Predicted target membrane receptor (t-SNARE) involved in vacuolar transport, endocytosis, and secretion; required for biofilm formation in RPMI-1640 and for virulence; rat catheter biofilm repressed
orf19.5876Candida albicans SC5314Protein of unknown function; Cyr1-repressed; induced by alpha pheromone in SpiderM medium; rat catheter and Spider biofilm induced
orf19.121ARC18Candida albicans SC5314Putative ARP2/3 complex subunit; mutation confers hypersensitivity to cytochalasin D
Locus IdGene NameOrganismDescription
orf19.122CDC20Candida albicans SC5314Activator of anaphase-promoting complex/cyclosome; induced under Cdc5 depletion; member of conserved Mcm1 regulon; mRNA expression peaks at cell-cycle G2/M phase; mRNA binds She3 and is localized to buds of yeast cells and to hyphal tips
orf19.6503Candida albicans SC5314Protein of unknown function
orf19.7160Candida albicans SC5314Protein of unknown function
orf19.125EBP1Candida albicans SC5314NADPH oxidoreductase; interacts with phenolic substrates (17beta-estradiol); possible role in estrogen response; induced by oxidative, weak acid stress, NO, benomyl, GlcNAc; Cap1, Mnl1 induced; Hap43-repressed; rat catheter biofilm induced
orf19.7163Candida albicans SC5314Protein of unknown function
orf19.6507Candida albicans SC5314Putative curved DNA-binding protein orthologous to S. pombe Cdb4; stationary phase enriched protein; rat catheter and Spider biofilm repressed
orf19.6508Candida albicans SC5314Protein of unknown function
orf19.6509Candida albicans SC5314Protein of unknown function
orf19.3960HYS2Candida albicans SC5314Putative DNA polymerase III (delta) subunit with a predicted role in DNA replication and DNA repair; cell-cycle regulated periodic mRNA expression
orf19.3963Candida albicans SC5314Protein of unknown function
orf19.3965Candida albicans SC5314Protein of unknown function
orf19.3966CRH12Candida albicans SC5314CRH family cell wall protein; transcript regulated by Nrg1 and Tup1; alkaline induced by Rim101; repressed during cell wall regeneration; flow model biofilm induced
orf19.1280SUI1Candida albicans SC5314Putative translation initiation factor; flucytosine induced; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage
orf19.3969SFL2Candida albicans SC5314Transcription factor involved in regulation of morphogenesis; required for filamentous growth, for virulence in RHE model but not in mice; induced upon RHE infection but C. dubliniensis ortholog is not; Spider biofilm induced
orf19.1283MEC1Candida albicans SC5314Cell cycle checkpoint protein with a role in genome integrity; RNA abundance regulated by tyrosol and cell density
orf19.1286Candida albicans SC5314Protein of unknown function
orf19.1288FOX2Candida albicans SC53143-hydroxyacyl-CoA epimerase; fatty acid beta-oxidation; induced by phagocytosis; regulated by Mig1, by white-opaque switch, by DNA methylation; transcriptional activation by oleate requires Ctf1; rat catheter and Spider biofilm induced
orf19.1289SCT1Candida albicans SC5314Putative glycerol-3-phosphate O-acyltransferase; fungal-specific (no human or murine homolog)
orf19.6510GRX1Candida albicans SC5314Putative glutaredoxin; induced in low iron
orf19.5290Candida albicans SC5314Protein of unknown function; repressed by Sfu1; Hap43-induced gene
Locus IdGene NameOrganismDescription
orf19.4634Candida albicans SC5314Protein required for thiolation of uridine at wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation; S. cerevisiae ortholog has a role in invasive and pseudohyphal growth
orf19.4635NIP1Candida albicans SC5314Putative translation initiation factor; mutation confers hypersensitivity to roridin A and verrucarin A; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage
orf19.5293Candida albicans SC5314Protein of unknown function
orf19.5294PDB1Candida albicans SC5314Putative pyruvate dehydrogenase; fluconazole-induced; protein level decreases in stationary phase cultures; Spider biofilm repressed
orf19.5295Candida albicans SC5314Protein with a predicted endonuclease/exonuclease/phosphatase family domain and a carbon catabolite repressor protein 4 domain; induced by alpha pheromone in SpiderM medium
orf19.4639Candida albicans SC5314Protein present in exponential and stationary growth phase yeast cultures
orf19.940BUD2Candida albicans SC5314GTPase activating protein (GAP) for Rsr1; negative regulator of filament branching, acts in hyphal growth guidance; required for wild-type budding pattern; induced in low iron; regulated by tyrosol and cell density
orf19.941SEC14Candida albicans SC5314Essential protein; functional homolog of S. cerevisiae Sec14p, a Golgi phosphatidylinositol/phosphatidylcholine transfer protein that regulates choline-phosphate cytidyltransferase and thereby affects secretion; biofilm-regulated
orf19.943FET33Candida albicans SC5314Putative multicopper ferro-O2-oxidoreductase; repressed in core caspofungin response; fails to complement S. cerevisiae fet3 iron-related phenotypes; rat catheter and Spider biofilm induced
orf19.945VPS2Candida albicans SC5314Protein of unknown function
orf19.946MET14Candida albicans SC5314Putative adenylylsulfate kinase; predicted role in sulfur metabolism; possibly adherence-induced; protein present in exponential and stationary growth phase yeast; F-12/CO2 biofilm induced
orf19.4640PWP1Candida albicans SC5314Putative rRNA processing protein; Hap43-induced; repressed in core stress response
orf19.4641NMT1Candida albicans SC5314Myristoyl-CoA:protein N-myristoyltransferase; attaches the fatty acid myristate to a small number of proteins at an N-terminal Gly; essential; antifungal drug target; functional homolog of S. cerevisiae Nmt1p
orf19.4642Candida albicans SC5314Protein of unknown function; Hap43-induced gene
orf19.1300Candida albicans SC5314Putative mitochondrial membrane protein; homozygous transposon insertion causes decreased colony wrinkling under filamentous growth-inducing conditions, but does not block true hyphal formation in liquid media
orf19.1301Candida albicans SC5314Protein of unknown function
orf19.4645BEM1Candida albicans SC5314Protein required for wild-type budding, hyphal growth, and virulence in a mouse systemic infection; suppresses pseudohyphal and filamentous growth defects of various S. cerevisiae mutants and heat sensitivity of S. cerevisiae cdc24-4 mutant
orf19.4646UEC1Candida albicans SC5314Protein required for damage to oral epithelial cells and for normal hyphal growth and stress resistance; transcription induced on contact with vascular endothelial cells; not highly conserved
orf19.725Candida albicans SC5314Protein of unknown function
orf19.726PPZ1Candida albicans SC5314Protein phosphatase Z; type 1 family serine/threonine specific protein phosphatase involved in cation homeostasis and cell wall integrity
Locus IdGene NameOrganismDescription
orf19.4423Candida albicans SC5314Putative glucosyltransferase; localized to the mitochondrial membrane
orf19.4426PEX3Candida albicans SC5314Putative peroxisomal protein involved in targeting proteins into peroxisomes; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.5083DRG1Candida albicans SC5314Member of the DRG family of GTP-binding proteins; involved in regulation of invasive filamentous growth
orf19.4428Candida albicans SC5314Protein of unknown function
orf19.5087BUD6Candida albicans SC5314Protein required for Spitzenkorper formation in hyphal cells (wild-type localization of Mlc1p to the Spitzenkorper); localizes to polarisome
orf19.5089TERTCandida albicans SC5314Telomerase reverse transcriptase; catalytic protein subunit of telomere synthesis; essential for telomerase activity; has telomerase-specific motif T and other conserved reverse transcriptase motifs
orf19.1883YCS4Candida albicans SC5314Putative condensin complex subunit; cell-cycle regulated periodic mRNA expression
orf19.1885TAF4Candida albicans SC5314Putative TFIID subunit; mutation confers hypersensitivity to toxic ergosterol analog
orf19.1887Candida albicans SC5314Protein of unknown function
orf19.729.1RGD3Candida albicans SC5314Putative Rho GTPase activating protein; fungal-specific (no human or murine homolog)
orf19.732Candida albicans SC5314Possible dehydrogenase; flow model biofilm induced; rat catheter biofilm induced; Spider biofilm induced
orf19.734GLK1Candida albicans SC5314Putative glucokinase; transcript regulated upon yeast-hyphal switch; Efg1 regulated; fluconazole-induced; induced in core stress response; colony morphology-related gene regulation by Ssn6; GlcNAc-induced protein
orf19.4430Candida albicans SC5314Protein of unknown function
orf19.738MYO5Candida albicans SC5314Class I myosin; nonessential; role in cortical actin patch polarity and polar budding; required for hyphal growth, white-opaque switch; regulatory phosphorylation on S366; downregulated on adherence to polystyrene
orf19.4432KSP1Candida albicans SC5314Putative serine/threonine protein kinase; mRNA binds She3 and is localized to hyphal tips; mutation confers hypersensitivity to amphotericin B
orf19.5090Candida albicans SC5314Protein of unknown function
orf19.5092Candida albicans SC5314Protein of unknown function
orf19.6458Candida albicans SC5314Protein of unknown function
orf19.6465Candida albicans SC5314Protein of unknown function
orf19.3190HAL9Candida albicans SC5314Putative Zn(II)2Cys6 transcription factor; gene in zinc cluster region of Chr. 5; induced by Mnl1 in weak acid; similar to S. cerevisiae Hal9, a putative transcription factor involved in salt tolerance
Locus IdGene NameOrganismDescription
orf19.5879Candida albicans SC5314Protein of unknown function
orf19.3193FCR3Candida albicans SC5314bZIP transcription factor; ortholog of S. cerevisiae Yap3; partially complements fluconazole sensitivity of S. cerevisiae pdr1 pdr3; Hap43-induced; required for yeast cell adherence to silicone substrate; flow model biofilm repressed
orf19.2537Candida albicans SC5314Protein of unknown function; transcript detected on high-resolution tiling arrays
orf19.3195HIP1Candida albicans SC5314Similar to amino acid permeases; alkaline, flucytosine induced; regulated by Plc1, Gcn2 and Gcn4; fungal-specific; Spider biofilm induced
orf19.3196Candida albicans SC5314Protein of unknown function
orf19.3197PAP1Candida albicans SC5314Poly(A) polymerase, likely involved in mRNA polyadenylation; PAP is inhibited by parnafungin antifungals; non-sex gene located within the MTLa mating-type-like locus
orf19.3198OBPACandida albicans SC5314Similar to oxysterol binding protein; non-sex gene located within the MTLa mating-type-like locus; Plc1p-regulated
orf19.3199PIKACandida albicans SC5314Putative phosphatidylinositol kinase; non-sex gene located within the MTLa mating-type-like locus
orf19.5880Candida albicans SC5314Putative voltage-gated chloride channel; predicted role in copper ion and iron ion homeostasis; flow model biofilm induced
orf19.2540SAS3Candida albicans SC5314Similar to silencing proteins; increased transcription is observed upon fluphenazine treatment; rat catheter biofilm repressed
orf19.2541Candida albicans SC5314Protein of unknown function
orf19.2542Candida albicans SC5314Protein of unknown function
orf19.5886CUP5Candida albicans SC5314Putative proteolipid subunit of the vacuolar H(+)-ATPase V0 sector; required for vacuolar acidification, secretion, filamentous growth; caspofungin repressed
orf19.5887NUP85Candida albicans SC5314Ortholog of S. cerevisiae Nup85; a structural constituent of the nuclear pore; required for alkaline-induced hyphal morphogenesis and for SD or Spider media biofilm formation
orf19.2544Candida albicans SC5314Protein of unknown function
orf19.2547Candida albicans SC5314Protein of unknown function
orf19.5890Candida albicans SC5314Protein of unknown function
orf19.5893RIP1Candida albicans SC5314Putative ubiquinol cytochrome c-reductase; induced by high iron; Hap43, nitric oxide, alkaline repressed; Spider biofilm repressed
orf19.131Candida albicans SC5314Protein of unknown function
orf19.6511LIG1Candida albicans SC5314tRNA ligase; functional homolog of S. cerevisiae Trl1
Locus IdGene NameOrganismDescription
orf19.6512EXO70Candida albicans SC5314Predicted subunit of the exocyst complex, involved in exocytosis; localizes to a crescent on the surface of the hyphal tip
orf19.134Candida albicans SC5314Protein of unknown function; overlaps retrotransposon Tca13; ciclopirox olamine induced
orf19.6514CUP9Candida albicans SC5314Transcription factor; represses SOK1 expression in response to farnesol inhibition; yeast-hypha switch repressed; ketoconazole-induced; Plc1-regulated; colony morphology-related Ssn6 regulation; Spider, flow model biofilm induced
orf19.6515HSP90Candida albicans SC5314Essential chaperone, regulates several signal transduction pathways and temperature-induced morphogenesis; activated by heat shock, stress; localizes to surface of hyphae, not yeast cells; mediates echinocandin and biofilm azole resistance
orf19.136QDR3Candida albicans SC5314Predicted membrane transporter, member of the drug:proton antiporter (12 spanner) (DHA1) family, major facilitator superfamily (MFS); Hap43p-repressed gene
orf19.7173Candida albicans SC5314Protein of unknown function
orf19.6518Candida albicans SC5314Predicted aldehyde dehydrogenase [NAD(P)+]; Spider biofilm induced
orf19.139TRA1Candida albicans SC5314Subunit of the NuA4 histone acetyltransferase complex
orf19.7175HLJ1Candida albicans SC5314Putative HSP40 co-chaperone; repressed during the mating process
orf19.7176NPT1Candida albicans SC5314Putative nicotinate phosphoribosyltransferase, involved in NAD salvage pathway; fungal-specific (no human or murine homolog)
orf19.7177KAP120Candida albicans SC5314Putative karyopherin; mutation confers hypersensitivity to cytochalasin D
orf19.7178PRE5Candida albicans SC5314Alpha6 subunit of the 20S proteasome; regulated by Gcn4; induced in response to amino acid starvation (3-AT); Spider biofilm repressed
orf19.7179Candida albicans SC5314Protein of unknown function
orf19.3971Candida albicans SC5314Protein of unknown function; early-stage flow model biofilm induced
orf19.3972Candida albicans SC5314Protein of unknown function
orf19.3973Candida albicans SC5314Ortholog of Hua1, a zinc finger domain protein with sequence similarity to Type I J-proteins; flow model biofilm induced
orf19.3974PUT2Candida albicans SC5314Putative delta-1-pyrroline-5-carboxylate dehydrogenase; alkaline upregulated; protein present in exponential and stationary growth phase yeast cultures; flow model biofilm induced; Spider biofilm induced
orf19.1304Candida albicans SC5314Protein of unknown function
orf19.1305Candida albicans SC5314Protein of unknown function
orf19.1306Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.4649ZCF27Candida albicans SC5314Putative Zn(II)2Cys6 transcription factor
orf19.952Candida albicans SC5314Protein of unknown function
orf19.954Candida albicans SC5314Putative DnaJ-like chaperone; Hap43-repressed gene
orf19.956Candida albicans SC5314Protein of unknown function
orf19.4650ILV6Candida albicans SC5314Putative regulatory subunit of acetolacetate synthase; alkaline induced; regulated by Gcn2 and Gcn4; protein present in exponential and stationary growth phase yeast; Spider biofilm repressed
orf19.4651PGA53Candida albicans SC5314GPI-anchored cell surface protein of unknown function; greater mRNA abundance observed in a cyr1 homozygous null mutant than in wild type
orf19.4652Candida albicans SC5314Protein of unknown function; rat catheter biofilm induced
orf19.1310Candida albicans SC5314Protein of unknown function
orf19.4653Candida albicans SC5314Protein similar to GPI-linked cell-wall proteins; induced in low iron; Spider biofilm induced; regulated in Spider biofilms by Bcr1, Tec1, Ndt80, Brg1
orf19.1311SPO75Candida albicans SC5314Protein of unknown function
orf19.4654Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.4655OPT6Candida albicans SC5314Putative oligopeptide transporter; fungal-specific (no human or murine homolog); expression of OPT6, OPT7, or OPT8 does not suppress defect of mutant lacking Opt1p, Opt2p, and Opt3p; alleles are nonidentical
orf19.4656Candida albicans SC5314Protein of unknown function
orf19.4657Candida albicans SC5314Protein of unknown function
orf19.4658Candida albicans SC5314RING finger and CHY zinc finger domain-containing protein; mutant are viable
orf19.1317OSH3Candida albicans SC5314Protein required for wild-type filamentation; has oxysterol binding protein domain and pleckstrin homology motif; overproducton suppresses cph1 homozygous null filamnetation defect; similar to S. cerevisiae Osh3p
orf19.7201SLA2Candida albicans SC5314Actin binding protein with roles in growth control and morphogenesis; required for alkaline pH-induced hyphal formation; localized to actin patches; rat catheter biofilm repressed
orf19.7202Candida albicans SC5314Protein of unknown function
orf19.7203MRP7Candida albicans SC5314Mitochondrial ribosomal protein of the large subunit; rat catheter biofilm induced
orf19.7205DUR7Candida albicans SC5314Putative urea transporter; fungal-specific (no human or murine homolog)
Locus IdGene NameOrganismDescription
orf19.4438RME1Candida albicans SC5314Zinc finger protein; controls meiosis in S. cerevisae; white-specific transcript; upregulation correlates with clinical development of fluconazole resistance; Upc2-regulated in hypoxia; flow model biofilm induced; Spider biofilm repressed
orf19.5095Candida albicans SC5314Putative oxysterol-binding protein; caspofungin induced; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.4439Candida albicans SC5314Protein of unknown function
orf19.5097CAT8Candida albicans SC5314Zn(II)2Cys6 transcription factor; similar to S. cerevisiae Cat8 but mutant phenotype suggests different target genes; mutant displays increased filamentous/invasive growth; flucytosine repressed; rat catheter biofilm induced
orf19.5098NTG1Candida albicans SC5314Protein with strong similarity to both S. cerevisiae Ntg1 and Ntg2 DNA repair glycosylases; transcript induced by iron; Hap43-repressed gene; Spider biofilm induced
orf19.1890Candida albicans SC5314Protein of unknown function
orf19.1891APR1Candida albicans SC5314Vacuolar aspartic proteinase; transcript equivalent in yeast-form and mycelial cells but is elevated at lower growth temperatures; upregulated iby human neutrophils; protein enriched in stationary phase; Spider biofilm induced
orf19.1893Candida albicans SC5314Protein of unknown function; Spider biofilm repressed
orf19.1896SSC1Candida albicans SC5314Heat shock protein; at yeast-form cell surface, not hyphae; antigenic; Gcn4-regulated; induced by amino acid starvation (3-AT) or by adherence to polystyrene; macrophage-repressed; sumoylation target; possibly essential
orf19.1897Candida albicans SC5314Protein of unknown function
orf19.741Candida albicans SC5314Dubious open reading frame
orf19.744GDB1Candida albicans SC5314Putative glycogen debranching enzyme; expression is regulated upon white-opaque switch; regulated by Nrg1, Tup1; rat catheter biofilm repressed
orf19.745VAC8Candida albicans SC5314Protein involved in vacuolar inheritance; required for hyphal growth; contains armadillo repeats
orf19.4440SEC34Candida albicans SC5314Protein of unknown function
orf19.4441Candida albicans SC5314Protein of unknown function
orf19.748Candida albicans SC5314Protein of unknown function
orf19.4444PHO15Candida albicans SC53144-nitrophenyl phosphatase, possible histone H2A phosphatase; involved in regulation of white-opaque switch; hyphal repressed; induced in core stress response; induced by cadmium stress via Hog1; rat catheter and Spider biofilm repressed
orf19.4447YMC1Candida albicans SC5314Putative inner mitochondrial membrane transporter; flucytosine induced; Spider biofilm repressed
orf19.1105Candida albicans SC5314Protein of unknown function
orf19.1106Candida albicans SC5314Protein with Mob2p-dependent hyphal regulation; fluconazole-induced
Locus IdGene NameOrganismDescription
orf19.1107Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.750Candida albicans SC5314Protein of unknown function; exogenously expressed protein is a substrate for Kex2p processing in vitro
orf19.2551MET6Candida albicans SC5314Essential 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase (cobalamin-independent methionine synthase); antigenic in murine/human systemic infection; heat shock, estrogen, GCN-induced; Spider biofilm repressed
orf19.2552Candida albicans SC5314Protein similar to S. cerevisiae Pmr1p; amphotericin B induced; previously merged with orf19.2553; unmerged from orf19.2553 in a revision of Assembly 21
orf19.5896Candida albicans SC5314Protein of unknown function; induced by alpha pheromone in SpiderM medium
orf19.5897Candida albicans SC5314Protein of unknown function
orf19.2559CDC4Candida albicans SC5314F-box subunit of SCF(CDC4) ubiquitin ligase; functional homolog of S. cerevisiae Cdc4; mutation/depletion causes hyperfilamentation; Sol1 is a substrate of SCF-Cdc4; Spider biofilm induced
orf19.5100MLT1Candida albicans SC5314Vacuolar membrane transporter; MRP subfamily of ABC family; may transport organic anions conjugated to glutathione, glucuronate, or sulfate; needed for virulence in mouse peritonitis; Spider biofilm induced; flow model biofilm repressed
orf19.5102PLB5Candida albicans SC5314Putative GPI-linked phospholipase B, fungal-specific (no mammalian homolog); null mutation eliminates cell-associated phospholipase A2 activity and attenuates virulence; fluconazole-repressed; flow model biofilm repressed
orf19.5104LTP1Candida albicans SC5314Putative protein phosphatase of the PTP family (tyrosine-specific), similar to S. cerevisiae Ltp1p
orf19.5106DIP2Candida albicans SC5314Putative small ribonucleoprotein complex; Tn mutation affects filamentous growth; physically interacts with TAP-tagged Nop1; heterozygous null mutant exhibits resistance to parnafungin; Hap43-induced gene; Spider biofilm induced
orf19.5107NOT5Candida albicans SC5314Protein with similarity to S. cerevisiae Not5p, a member of the transcription regulatory CCR4-NOT complex; required for hyphal growth; antigenic during human oral infection; greater expression in yeast-form cells than hyphae
orf19.1906Candida albicans SC5314Protein of unknown function; flow model biofilm induced
orf19.1907EMC9Candida albicans SC5314Ortholog of S. cerevisiae Nnf2; possible role in chromosome segregation; mutants are viable, induced during the mating process
orf19.2564Candida albicans SC5314Putative nucleolar protein; implicated in ribosome biogenesis; rat catheter biofilm repressed
orf19.2568IFU5Candida albicans SC5314Predicted membrane protein; estradiol-induced; upregulation associated with CDR1 and CDR2 overexpression or fluphenazine; putative drug-responsive regulatory site; similar to S. cerevisiae Wwm1p; Hap43-repressed; Spider biofilm repressed
orf19.5112TKL1Candida albicans SC5314Putative transketolase; localizes to surface of yeast cells, not hyphae; soluble protein in hyphae; transcript regulated by Nrg1, Mig1, and Tup1; antigenic in human or murine infection; possibly essential (by UAU1 method)
orf19.5113ADH2Candida albicans SC5314Alcohol dehydrogenase; soluble in hyphae; expression regulated by white-opaque switching; regulated by Ssn6; indued by Mnl1 in weak acid stress; protein enriched in stationary phase yeast cultures; Spider biofilm induced
orf19.5117OLE1Candida albicans SC5314Fatty acid desaturase, essential protein involved in oleic acid synthesis; required for aerobic hyphal growth and chlamydospore formation; subject to hypoxic regulation; fluconazole-induced; caspofungin repressed; Hap43p-induced
orf19.3976Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.3977Candida albicans SC5314Protein with a role in translation; flow model biofilm repressed
orf19.3978Candida albicans SC5314Protein required for maturation of 18S rRNA; rat catheter biofilm repressed
orf19.1291ABZ1Candida albicans SC5314Protein of unknown function
orf19.1295VAS1Candida albicans SC5314Putative tRNA-Val synthetase; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage
orf19.1297Candida albicans SC5314Protein of unknown function
orf19.1299RPN6Candida albicans SC5314Putative 26S proteasome subunit; Hap43p-induced gene; regulated by Gcn2p and Gcn4p
orf19.144SNU114Candida albicans SC5314Protein similar to S. cerevisiae Snu114p, which is an RNA helicase involved in pre-mRNA splicing; likely to be essential for growth, based on an insertional mutagenesis strategy
orf19.6524TOM40Candida albicans SC5314Protein involved in mitochondrial protein import; Spider biofilm repressed
orf19.7181Candida albicans SC5314Protein of unknown function
orf19.7182Candida albicans SC5314Protein of unknown function
orf19.6526Candida albicans SC5314Protein of unknown function
orf19.7183Candida albicans SC5314Protein of unknown function
orf19.6527Candida albicans SC5314Pheromone-regulated protein (Prm10) of S. cerevisiae; colony morphology-related gene regulation by Ssn6; induced by Mnl1 under weak acid stress; possibly essential gene, disruptants not obtained by UAU1 method; Spider biofilm induced
orf19.7184Candida albicans SC5314Protein of unknown function
orf19.149Candida albicans SC5314Protein of unknown function; transcript detected on high-resolution tiling arrays
orf19.6529CDC34Candida albicans SC5314Putative ubiquitin-protein ligase; transcript regulated by Nrg1 and Tup1, and by Gcn2 and Gcn4; rat catheter biofilm induced
orf19.7187MAM33Candida albicans SC5314Putative mitochondrial acidic matrix protein; regulated by Ssn6p; protein present in exponential and stationary growth phase yeast cultures
orf19.3980Candida albicans SC5314Protein of unknown function
orf19.3981MAL31Candida albicans SC5314Putative high-affinity maltose transporter; transcript is upregulated in clinical isolates from HIV+ patients with oral candidiasis; alkaline induced; Spider biofilm induced
orf19.3983Candida albicans SC5314Protein with a predicted transcription factor BTF3 domain; flow model biofilm induced
Locus IdGene NameOrganismDescription
orf19.3124Candida albicans SC5314Protein of unknown function
orf19.5057Candida albicans SC5314Protein of unknown function
orf19.7206OCA6Candida albicans SC5314Putative protein phosphatase of the PTP family (tyrosine-specific), similar to S. cerevisiae Oca6p; mutant shows virulence defect
orf19.7207DOA4Candida albicans SC5314Ortholog of S. cerevisiae Doa4;, a ubiquitin hydrolase involved in recycling ubiquitin from proteasome-bound ubiquitinated intermediates; oxidative stress-induced via Cap1; mutants are viable
orf19.7208CSK1Candida albicans SC5314Putative mitogen-activated protein (MAP) kinase with an unknown role; null mutant produces wrinkled colonies; similar to S. cerevisiae Smk1p, which is a protein kinase required for sporulation
orf19.966DUS4Candida albicans SC5314Protein of unknown function
orf19.4660RPS6ACandida albicans SC5314Ribosomal protein 6A; localizes to cell surface of yeast cells but not hyphae; repressed upon phagocytosis by murine macrophage; possibly essential; Hap43-induced; Spider biofilm repressed
orf19.969Candida albicans SC5314Protein of unknown function
orf19.1321HWP1Candida albicans SC5314Hyphal cell wall protein; host transglutaminase substrate; opaque-, a-specific, alpha-factor induced; at MTLa side of conjugation tube; virulence complicated by URA3 effects; Bcr1-repressed in RPMI a/a biofilms; Spider biofilm induced
orf19.4665Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.1323Candida albicans SC5314Phosphorylated protein of unknown function; Hap43p-repressed gene
orf19.1324RAD2Candida albicans SC5314Ortholog of S. cerevisiae Rad2, a nucleotide excision repair nuclease; null mutant is extremely sensitive to UV irradiation; transcript induced by interaction with macrophages
orf19.4668Candida albicans SC5314Protein with a glycoside hydrolase domain; mutants are viable
orf19.1326Candida albicans SC5314Protein of unknown function
orf19.1327RBT1Candida albicans SC5314Cell wall protein with similarity to Hwp1; required for virulence; predicted glycosylation; fluconazole, Tup1 repressed; farnesol, alpha factor, serum, hyphal and alkaline induced; Rfg1, Rim101-regulated
orf19.7210Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.7212Candida albicans SC5314Phosphorylated protein; homozygous transposon insertion causes decreased colony wrinkling in filamentous growth-inducing conditions, but does not block hyphal formation in liquid media; Hap43-repressed
orf19.7213Candida albicans SC5314Putative ATP-dependent RNA helicase; fungal-specific (no human or murine homolog)
orf19.7215Candida albicans SC5314Nucleolar protein; component of the small subunit processome containing the U3 snoRNA; involved in pre-18S rRNA processing; flow model biofilm repressed
orf19.7217RPL4BCandida albicans SC5314Ribosomal protein 4B; repressed upon phagocytosis by murine macrophage; Spider biofilm repressed
Locus IdGene NameOrganismDescription
orf19.972Candida albicans SC5314Protein of unknown function
orf19.752Candida albicans SC5314Protein of unknown function
orf19.754YBN5Candida albicans SC5314P-loop ATPase with similarity to human OLA1 and bacterial YchF; Spider biofilm repressed
orf19.756SAP7Candida albicans SC5314Pepstatin A-insensitive secreted aspartyl protease; self-processing; expressed in human oral infection; Ssn6p-regulated; role in murine intravenous infection; induced during, but not required for, murine vaginal infection; N-glycosylated
orf19.4451RIA1Candida albicans SC5314Putative translation elongation factor; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage
orf19.759SEC21Candida albicans SC5314Protein of unknown function
orf19.1110Candida albicans SC5314Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate); active as a homodimer
orf19.4455Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.1113Candida albicans SC5314Protein of unknown function
orf19.1114Candida albicans SC5314Cytochrome c oxidase subunit; membrane-localized protein; rat catheter biofilm induced
orf19.4459Candida albicans SC5314Predicted heme-binding stress-related protein; Tn mutation affects filamentous growth; induced during chlamydospore formation in C. albicans and C. dubliniensis; Spider biofilm induced
orf19.1117Candida albicans SC5314Protein similar to Candida boidinii formate dehydrogenase; virulence-group-correlated expression; Hap43-repressed; Spider biofilm repressed
orf19.7002Candida albicans SC5314Protein of unknown function
orf19.761TCO89Candida albicans SC5314Putative homolog of S. cerevisiae Tco89p, which is a component of the TOR C1 complex that is involved in the regulation of growth and cell wall integrity; heterozygous null mutant displays sensitivity to rapamycin
orf19.762Candida albicans SC5314Protein of unknown function
orf19.7009Candida albicans SC5314Protein of unknown function
orf19.3801FAV1Candida albicans SC5314Protein with weak similarity to S. cerevisiae Fus2p; induced by alpha pheromone mating factor in MTLa/MTLa opaque cells
orf19.764Candida albicans SC5314Protein of unknown function
orf19.3802PMT6Candida albicans SC5314Protein mannosyltransferase; required for virulence in mice, adhesion to endothelium; role in hyphal growth signaling, hygromycin B sensitivity; no major role in cellular PMT activity; Hap4-repressed; Bcr1-repressed in RPMI a/a biofilms
orf19.767ERG3Candida albicans SC5314C-5 sterol desaturase; introduces C-5(6) double bond into episterol; some clinical isolates show increased azole resistance and defects in hyphal growth and virulence; Efg1p-repressed; fluconazole-induced
Locus IdGene NameOrganismDescription
orf19.4461Candida albicans SC5314Protein of unknown function
orf19.1910Candida albicans SC5314Predicted NADH-dependent flavin oxidoreductase; Hap43-repressed gene
orf19.1913Candida albicans SC5314Protein of unknown function; flow model biofilm induced
orf19.1914FAV3Candida albicans SC5314Putative alpha-1,6-mannanase; induced by mating factor in MTLa/MTLa opaque cells
orf19.2571SEC4Candida albicans SC5314Small GTPase of Rab family; role in post-Golgi secretion; possible C-terminal palmitoylation; downregulated on adherence to polystyrene; localizes to the Spitzenkorper during hyphal growth; functional homolog of S. cerevisiae Sec4p
orf19.2573FRS1Candida albicans SC5314Phenylalanyl-tRNA synthetase; possible role in early cell wall biosynthesis; downregulated by phagocytosis by macrophages; possibly essential gene, disruptants not obtained by UAU1 method; protein present in exponential and stationary phase
orf19.2574Candida albicans SC5314Protein of unknown function
orf19.2575Candida albicans SC5314Putative S-adenosylmethionine-dependent methyltransferase; Hap43p-induced gene
orf19.5121OPT5Candida albicans SC5314Oligopeptide transporter; fungal-specific (no human or murine homolog); induced by BSA, but not by tetrapeptide or pentapeptide
orf19.5124RBR3Candida albicans SC5314Cell wall adhesin-like protein; repressed by Rim101; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.5126Candida albicans SC5314Putative adhesin-like protein
orf19.1920Candida albicans SC5314Protein of unknown function
orf19.5129Candida albicans SC5314Protein of unknown function
orf19.1923RRN3Candida albicans SC5314Protein with a predicted role in recruitment of RNA polymerase I to rDNA; caspofungin induced; flucytosine repressed; repressed in core stress response; repressed by prostaglandins
orf19.2580HST2Candida albicans SC5314Putative histone deacetylase; role in regulation of white-opaque switch; Spider biofilm induced
orf19.2581Candida albicans SC5314Protein with a predicted epimerase/dehydratase domain; Hap43-repressed gene
orf19.2583PTR2Candida albicans SC5314Oligopeptide transporter involved in uptake of di-/tripeptides; highly induced during chlamydospore formation in both C. albicans and C. dubliniensis
orf19.1927SNM1Candida albicans SC5314Protein similar to RNase MRP RNA binding protein; ciclopirox olamine induced; regulated by Sef1, Sfu1, and Hap43; Spider biofilm induced
orf19.2587HNM3Candida albicans SC5314Putative transporter; Hap43, flucytosine repressed; possibly essential, disruptants not obtained by UAU1 method; Spider biofilm induced
orf19.5131Candida albicans SC5314Ortholog of S. cerevisiae Gid7, a GID complex protein; involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; Hap43-repressed gene
Locus IdGene NameOrganismDescription
orf19.5133ZCF29Candida albicans SC5314Zn(II)2Cys6 transcription factor; mutants sensitive to caffeine and menadione, resistant to fenpropimorph; Hap43-repressed; mutants have decreased CFU in mouse kidneys and defects in filamentous growth; Spider biofilm induced
orf19.5134Candida albicans SC5314Protein of unknown function
orf19.3986PPR1Candida albicans SC5314Putative transcription factor with zinc cluster DNA-binding motif; has similarity to S. cerevisiae Ppr1p, which is a transcription factor involved in the regulation of uracil biosynthesis genes
orf19.6530Candida albicans SC5314Similar to bacterial DnaJ; transcript upregulated in low iron; flow model biofilm induced; Spider biofilm induced
orf19.6533MSK1Candida albicans SC5314Putative mitochondrial lysine-tRNA synthetase; flucytosine repressed
orf19.7190OGG1Candida albicans SC5314Mitochondrial glycosylase/lyase; repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance, role in base-excision repair; Spider biofilm induced
orf19.6534Candida albicans SC5314Protein of unknown function
orf19.156FGR51Candida albicans SC5314Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth; Hap43p-repressed gene
orf19.6536IQG1Candida albicans SC5314Actomyosin ring component at bud neck; cell-cycle regulated ser phosphorylation at CDK sites regulate association with Bni1/Bnr1, Iqg1 degradation, and ring disassembly; mutation causes cytokinetic defects; rat catheter biofilm repressed
orf19.158Candida albicans SC5314Ortholog of S. cerevisiae Apd1; required for normal localization of actin patches and normal tolerance of sodium ions and hydrogen peroxide; Hap43-induced; Spider biofilm induced
orf19.7194Candida albicans SC5314Protein required for virulence in reconstituted human epithelium (RHE) model of ex vivo infection; decreased transcription is observed upon fluphenazine treatment; induced upon adherence to polystyrene
orf19.6538VMA11Candida albicans SC5314Predicted ortholog of S. cerevisiae Tfp3/Vma11; c' subunit of the V0 subcomplex of the vacuolar ATPase; required for hemoglobin-iron utilization; Spider biofilm repressed
orf19.7195RAD6Candida albicans SC5314Functional ortholog of S. cerevisiae Rad6; negative regulator of hyphal growth; required for wild-type UV resistance; acts in pathway with Efg1; ; transcript is UV-induced, slightly repressed during hyphal growth; gene has two introns
orf19.6539Candida albicans SC5314Putative trancription modulator; RuvB-like protein family member; heterozygous null mutant displays sensitivity to virgineone
orf19.7196Candida albicans SC5314Putative vacuolar protease; upregulated in the presence of human neutrophils; Spider biofilm induced
orf19.7197Candida albicans SC5314Putative intranuclear transport and DNA replication mediator; heterozygous null mutant exhibits resistance to parnafungin in the C. albicans fitness test; Spider biofilm induced
orf19.7198Candida albicans SC5314CCR4-NOT complex component; involved in controlling mRNA initiation, elongation and degradation; rat catheter biofilm induced
orf19.3990Candida albicans SC5314Protein of unknown function
orf19.7199Candida albicans SC5314Protein of unknown function
orf19.3991Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.3994Candida albicans SC5314Dolichyl-diphosphooligosaccharide-protein glycotransferase; predicted role in protein N-linked glycosylation, protein O-linked mannosylation; Spider biofilm repressed
orf19.7219FTR1Candida albicans SC5314High-affinity iron permease; required for mouse virulence, low-iron growth; iron, amphotericin B, caspofungin, ciclopirox, Hog1p, Sef1p, Sfu1p, and Hap43p regulated; complements S. cerevisiae ftr1 iron transport; Hap43p-repressed
orf19.974ROT2Candida albicans SC5314Alpha-glucosidase II, catalytic subunit, required for N-linked protein glycosylation and normal cell wall synthesis; alkaline downregulated
orf19.976BRE1Candida albicans SC5314Putative transcription factor with C3HC4 zinc finger DNA-binding motif; similar to S. cerevisiae Bre1p; transposon mutation affects filamentous growth
orf19.978BDF1Candida albicans SC5314Bromodomain transcription factor; repressed upon adherence to polystyrene; reduced mRNA abundance detected in null mutant; macrophage/pseudohyphal-repressed; possibly essential, disruptants not obtained by UAU1 method
orf19.979FAS1Candida albicans SC5314Beta subunit of fatty-acid synthase; multifunctional enzyme; Hap43, fluconazole-induced; amphotericin B, caspofungin repressed; macrophage/pseudohyphal-induced; flow model and Spider biofilm repressed
orf19.1330Candida albicans SC5314Protein of unknown function
orf19.1331HSM3Candida albicans SC5314Protein of unknown function
orf19.4675ASK1Candida albicans SC5314Essential subunit of the Dam1 (DASH) complex, which acts in chromosome segregation by coupling kinetochores to spindle microtubules
orf19.4676Candida albicans SC5314Protein with homology to mitochondrial intermembrane space proteins; regulated by Sef1p-, Sfu1p-, and Hap43p
orf19.4677Candida albicans SC5314Putative protein of unknown function, transcript is upregulated in clinical isolates from HIV+ patients with oral candidiasis; Spider biofilm induced
orf19.1335Candida albicans SC5314Ortholog of S. cerevisiae Mtr4, an ATP-dependent 3'-5' RNA helicase of the DEAD-box family; Hap43-induced gene; Spider biofilm induced
orf19.1336PUP3Candida albicans SC5314Putative beta 3 subunit of the 20S proteasome; macrophage/pseudohyphal-repressed
orf19.4679AGP2Candida albicans SC5314Amino acid permease; hyphal repressed; white-opaque switch regulated; induced in core caspofungin response, during cell wall regeneration, by flucytosine; regulated by Sef1, Sfu1, and Hap43; rat catheter and Spider biofilm induced
orf19.1338Candida albicans SC5314Protein of unknown function; possible COPI-coated vesicle, Golgi apparatus, ribosome localization; rat catheter biofilm repressed
orf19.1339CPY1Candida albicans SC5314Carboxypeptidase Y; transcript regulated at yeast-hypha transition or macrophage response; induced human neutrophils; regulated by Gcn2 and Gcn4; putative N-glycosylation
orf19.7221SET3Candida albicans SC5314NAD-dependent histone deacetylase; mutations affect filamentous growth; genetic evidence suggests Set3/Hos2 function as a complex to regulate white-opaque switching, morphogenesis, and virulence; flow model biofilm induced
orf19.7222PAM16Candida albicans SC5314Putative maltase; regulated by Gcn4; repressed by amino acid starvation (3-AT); rat catheter biofilm induced
orf19.7223Candida albicans SC5314Protein of unknown function
orf19.7224Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.7225Candida albicans SC5314Protein of unknown function
orf19.768SYG1Candida albicans SC5314Protein of unknown function
orf19.769IFE1Candida albicans SC5314Putative medium-chain alcohol dehydrogenase; rat catheter and Spider biofilm repressed
orf19.1120FAV2Candida albicans SC5314Adhesin-like protein; induced by mating factor in MTLa/a opaque cells, in cyr1 null, in filaments; regulated by Nrg1, Rfg1, Tup1, Tec1, Efg1, Ntd80, Rob1, Brg1; induced in oralpharyngeal candidasis; Spider biofilm induced
orf19.1121Candida albicans SC5314Protein of unknown function
orf19.1122Candida albicans SC5314Protein of unknown function; induced by alpha pheromone in SpiderM medium; Spider biofilm induced
orf19.1123Candida albicans SC5314Dubious open reading frame
orf19.4468Candida albicans SC5314Putative succinate dehydrogenase; localized to the mitochondrial membrane; Hap43p-repressed gene
orf19.7010Candida albicans SC5314Protein of unknown function
orf19.7011Candida albicans SC5314Protein of unknown function
orf19.7013Candida albicans SC5314Protein of unknown function
orf19.7015RPP0Candida albicans SC5314Putative ribosomal protein; antigenic in mouse; repressed upon phagocytosis by murine macrophage; induced by Tbf1; overlaps orf19.7014; Spider biofilm repressed
orf19.7016PHM5Candida albicans SC5314Protein of unknown function
orf19.772LYS21Candida albicans SC5314Homocitrate synthase; lysine biosynthesis; expression increased in a fluconazole-resistant isolate; colony morphology-related gene regulation by Ssn6; ketoconazole-repressed; regulated by Gcn2, Gcn4, Hap43
orf19.7017YOX1Candida albicans SC5314Putative homeodomain-containing transcription factor; transcriptional repressor; periodic mRNA expression, peak at cell-cycle G1/S phase
orf19.3810Candida albicans SC5314Protein of unknown function
orf19.7019YML6Candida albicans SC5314Putative mitochondrial ribosomal protein; induced upon adherence to polystyrene
orf19.3811GYP1Candida albicans SC5314Putative Cis-golgi GTPase-activating protein; transcript regulated by Nrg1, Mig1, and Tup1
orf19.3812SSZ1Candida albicans SC5314Putative HSP70 chaperone; protein level decreases in stationary phase cultures; Spider biofilm repressed
orf19.775Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.3815Candida albicans SC5314Protein of unknown function
orf19.4472Candida albicans SC5314Protein of unknown function
orf19.938Candida albicans SC5314Protein of unknown function
orf19.4437Candida albicans SC5314Protein of unknown function
orf19.1109Candida albicans SC5314Protein of unknown function
orf19.5136Candida albicans SC5314Putative pyridoxamine 5'-phosphate oxidase; planktonic growth and early-stage flow model biofilm induced
orf19.5138IFA21Candida albicans SC5314IPF family A protein; mutants are viable; Spider biofilm induced
orf19.1930CFL5Candida albicans SC5314Ferric reductase; induced in low iron; ciclopirox olamine, flucytosine induced; amphotericin B, Sfu1 repressed; Tbf1, Hap43 induced
orf19.1932CFL4Candida albicans SC5314C-terminus similar to ferric reductases; induced in low iron; Sfu1-repressed; ciclopirox olamine induced; colony morphology-related gene regulation by Ssn6; Hap43-repressed; Sef1-regulated
orf19.2590Candida albicans SC5314Putative dethiobiotin synthetase; transcript upregulated in clinical isolates from HIV+ patients with oral candidiasis; Hap43-repressed; GlcNAc-induced protein; Spider biofilm induced
orf19.1934HST3Candida albicans SC5314Histone H3K56 deacetylase; reduced copy number increases opaque cell formation; repressed by MMS, hydroxyurea and high-levels of hydrogen peroxide; Hap43p-induced; ectopic expression blocks genotoxin-induced switching; nicotinamide target
orf19.1935Candida albicans SC5314Dubious open reading frame
orf19.2594Candida albicans SC5314Protein of unknown function
orf19.2597MRS2Candida albicans SC5314Putative magnesium ion transporter, mitochondrial; fungal-specific (no human or murine homolog)
orf19.2599CRC1Candida albicans SC5314Mitochondrial carnitine carrier protein
orf19.5140Candida albicans SC5314Protein of unknown function; rat catheter and Spider biofilm induced
orf19.5142DFR1Candida albicans SC5314Trimethoprim resistant dihydrofolate reductase (DHFR), reduces 7,8-dihydrofolate to 5,4,7,8-tetrahydrofolate; binds NADPH; target of drugs that selectively inhibit the fungal enzyme rather than the human enzyme
orf19.5145SSP96Candida albicans SC5314Putative flavin-containing monooxygenase; F-12/CO2 early biofilm induced
orf19.5148CYR1Candida albicans SC5314Class III adenylyl cyclase; mutant lacks cAMP; mutant hyphal growth defect rescued by exogenous cAMP; required for mouse mucosal or systemic infection; role in macrophage sensitivity, apoptosis; downstream of Ras1p and CO2 signaling
orf19.1941NUF2Candida albicans SC5314Kinetochore component; amount of Nuf2p and Mtw1p protein detected at each centromere is consistent with a single kinetochore microtubule attachment site
Locus IdGene NameOrganismDescription
orf19.1943Candida albicans SC5314Protein of unknown function
orf19.1944GPR1Candida albicans SC5314Plasma membrane G-protein-coupled receptor of the cAMP-PKA pathway; required for WT hyphal growth; reports differ on role in cAMP-mediated glucose signaling; Gpr1 C terminus binds Gpa2; regulates HWP1 and ECE1; flow model biofilm induced
orf19.1946Candida albicans SC5314Similar to an aldose 1-epimerase-related protein; antigenic during murine systemic infection; protein present in exponential and stationary phase yeast cultures; Hap43-induced; Spider biofilm repressed
orf19.1949VPS1Candida albicans SC5314Dynamin-family GTPase-related protein; induced upon adherence to polystyrene; regulated by Gcn2p and Gcn4p
orf19.5155CHS6Candida albicans SC5314Protein with tetratricopeptide repeats (TPRs); ortholog of S. cerevisiae Chs6, which has role in localizing chitin synthase; Cyr1-regulated in hyphae; possibly essential, disruptants not obtained by UAU1 method; flow model biofilm repressed
orf19.3471Candida albicans SC5314Protein with a predicted anaphase-promoting complex APC subunit 1 CDC26 domain; Hap43-repressed gene
orf19.2818Candida albicans SC5314Protein of unknown function
orf19.3476HRR25Candida albicans SC5314Predicted protein serine/threonine kinase; Spider biofilm induced
orf19.3477Candida albicans SC5314Putative pseudouridine synthase; predicted role in snRNA pseudouridine synthesis, tRNA pseudouridine synthesis; Spider biofilm induced
orf19.3478NIP7Candida albicans SC5314Putative nucleolar protein with role in ribosomal assembly; hyphal-induced; Hap43-induced; Spider biofilm induced
orf19.6020Candida albicans SC5314Protein of unknown function
orf19.6021IHD2Candida albicans SC5314Protein of unknown function; induced during hyphae development; induced in low iron; Spider biofilm induced
orf19.6025Candida albicans SC5314Protein of unknown function
orf19.6027Candida albicans SC5314Protein of unknown function
orf19.6028HGC1Candida albicans SC5314Hypha-specific G1 cyclin-related protein involved in regulation of morphogenesis, biofilm formation; Cdc28-Hgc1 maintains Cdc11 S394 phosphorylation during hyphal growth; required for virulence in mice; regulated by Nrg1, Tup1, farnesol
orf19.6029ROT1Candida albicans SC5314Similar to S. cerevisiae Rot1p, which is involved in cell wall 1,6-beta-glucan biosynthesis; has predicted transmembrane region; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.2822Candida albicans SC5314Essential component of the conserved oligomeric Golgi complex; role in fusion of transport vesicles to Golgi compartments; rat catheter biofilm repressed
orf19.2823RFG1Candida albicans SC5314HMG domain transcriptional repressor of filamentous growth and hyphal genes; in Tup1-dependent and -independent pathways; binds DNA; transcript not regulated by oxygen or serum; not responsible for hypoxic repression; Spider biofilm induced
orf19.3480Candida albicans SC5314Protein of unknown function
orf19.3481Candida albicans SC5314Putative mitochondrial ATP-dependent RNA helicase of the DEAD-box family, transcription is activated in the presence of elevated CO2
Locus IdGene NameOrganismDescription
orf19.2826Candida albicans SC5314Protein of unknown function
orf19.2827Candida albicans SC5314Protein of unknown function
orf19.2828Candida albicans SC5314Protein of unknown function
orf19.3487Candida albicans SC5314Protein of unknown function
orf19.6030Candida albicans SC5314Protein of unknown function; transcript detected on high-resolution tiling arrays
orf19.7475PHO81Candida albicans SC5314Protein involved in regulation of hyphal development; required for response to farnesoic acid; possibly adherence-induced
orf19.4133Candida albicans SC5314Protein wth a predicted role in transcription from RNA polymerase II promoters; Spider biofilm induced
orf19.7477YRB1Candida albicans SC5314Functional homolog of S. cerevisiae Yrb1p; regulates Gsp1 GTPase activity and thereby affects nucleocytoplasmic transport and cytoskeletal dynamics; transcript is not regulated by white-opaque switch or by dimorphic transition
orf19.7478Candida albicans SC5314Protein of unknown function
orf19.4135PRC2Candida albicans SC5314Putative carboxypeptidase; induced by human neutrophils; Spider biofilm induced
orf19.7479NTH1Candida albicans SC5314Neutral trehalase; hyphal induction in mutant delayed but not reduced overall; not required for virulence in mice; possible regulatory cAMP-dependent phosphorylation at S10,S213; Hap43-repressed gene; Spider biofilm induced
orf19.1592Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.1595Candida albicans SC5314Protein of unknown function
orf19.1597ABG1Candida albicans SC5314Vacuolar membrane protein; depletion causes abnormal vacuolar morphology, cell separation defect, sensitivity to cell wall stress, increased hyphal branching; essential, no mammalian homolog; Cyr1-regulated; rat catheter biofilm repressed
orf19.1598ERG24Candida albicans SC5314C-14 sterol reductase, has a role in ergosterol biosynthesis; mutation confers increased sensitivity to dyclonine; rat catheter and Spider biofilm repressed
orf19.440SDH1Candida albicans SC5314Putative mitochondrial succinate dehydrogenase; macrophage/pseudohyphal-induced; repressed by nitric oxide
orf19.6821Candida albicans SC5314Protein of unknown function
orf19.6822Candida albicans SC5314Protein of unknown function
orf19.443Candida albicans SC5314Protein of unknown function
orf19.445Candida albicans SC5314Protein of unknown function; repressed by prostaglandins
Locus IdGene NameOrganismDescription
orf19.7481MDH1Candida albicans SC5314Mitochondrial malate dehydrogenase; regulated by Mig1, Tup1, white-opaque switch, phagocytosis; induced in high iron; antigenic during murine and human infection; repressed in Spider biofilms by Bcr1, Tec1, Ndt80, Rob1, Brg1
orf19.6826SLF1Candida albicans SC5314Putative polysome-associated RNA binding protein; macrophage-induced gene
orf19.7483CRM1Candida albicans SC5314Functional homolog of S. cerevisiae Crm1, which acts in protein nuclear export; predicted to be resistant to antifungal drug leptomycin B; partially suppresses signal transduction defects of S. cerevisiae ste20 mutant
orf19.448CUE5Candida albicans SC5314Predicted ubiquitin-binding protein; rat catheter biofilm repressed
orf19.7484ADE1Candida albicans SC5314Phosphoribosylaminoimadazole succinocarboxamide synthetase, enzyme of adenine biosynthesis; not induced in GCN response, unlike the S. cerevisiae ortholog; fungal-specific (no human or murine homolog); levels decrease in stationary phase
orf19.2262Candida albicans SC5314Protein similar to quinone oxidoreductases; induced by benomyl treatment, nitric oxide; oxidative stress-induced via Cap1; stationary-phase enriched protein; Spider biofilm induced
orf19.2263Candida albicans SC5314Protein of unknown function
orf19.2264OLE2Candida albicans SC5314Protein with similarity to fatty acid desaturase (stearoyl-CoA desaturase); homozygous null mutant shows decreased production of prostaglandin E2
orf19.1608Candida albicans SC5314Protein of unknown function
orf19.1609Candida albicans SC5314Protein of unknown function
orf19.2266Candida albicans SC5314Protein of unknown function
orf19.2267RFA2Candida albicans SC5314Putative DNA replication factor A; RNA abundance regulated by cell cycle, tyrosol and cell density
orf19.2268RCK2Candida albicans SC5314Predicted MAP kinase-activated protein kinase, similar to S. cerevisiae serine/threonine protein kinase Rck2p; induced by osmotic stress via Hog1p; macrophage/pseudohyphal-repressed; mutants are sensitive to rapamycin
orf19.2269Candida albicans SC5314Putative 3-phosphoserine phosphatase; induced by benomyl or in azole-resistant strain that overexpresses MDR1; early-stage flow model biofilm induced; Spider biofilm repressed
orf19.4950AKR1Candida albicans SC5314Ankyrin-repeat protein; induced by fluphenazine
orf19.4952Candida albicans SC5314Protein of unknown function; flow model biofilm induced; Spider biofilm induced
orf19.1610Candida albicans SC5314Putative protein of unknown function, transcription is activated in the presence of elevated CO2
orf19.4954Candida albicans SC5314Protein of unknown function
orf19.1611Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.1613ILV2Candida albicans SC5314Putative acetolactate synthase; regulated by Gcn4p; induced by amino acid starvation (3-AT treatment); stationary phase enriched protein
Locus IdGene NameOrganismDescription
orf19.1614MEP1Candida albicans SC5314Ammonium permease; Mep1 more efficient permease than Mep2, Mep2 has additional regulatory role; 11 predicted transmembrane regions; low mRNA abundance; hyphal downregulated; flow model biofilm induced
orf19.4959Candida albicans SC5314Protein of unknown function; Spider biofilm repressed
orf19.2272AFT2Candida albicans SC5314Putative Aft domain transcription factor; role in regulation of iron metabolism, oxidative stress, adhesion, hyphal growth, colony morphology, virulence; complements S. cerevisiae aft1 mutation; Spider biofilm induced
orf19.1617Candida albicans SC5314Protein similar to S. cerevisiae Ydr282cp; transposon mutation affects filamentous growth; Hap43p-repressed gene
orf19.2275Candida albicans SC5314Putative mitochondrial ribosomal protein; predicted role in aerobic respiration; Spider biofilm repressed
orf19.2276Candida albicans SC5314Protein of unknown function
orf19.2277TPK2Candida albicans SC5314cAMP-dependent protein kinase catalytic subunit; isoform of Tpk1; needed for epithelial cell damage, engulfment and oral (not systemic) virulence in mice; control of morphogenesis and stress response; rat catheter, Spider biofilm repressed
orf19.7500PXA1Candida albicans SC5314Putative peroxisomal, half-size adrenoleukodystrophy protein (ALD or ALDp) subfamily ABC family transporter
orf19.4738Candida albicans SC5314Protein of unknown function
orf19.5395Candida albicans SC5314Protein of unknown function
orf19.4739MSS116Candida albicans SC5314Putative DEAD-box protein; required for efficient splicing of mitochondrial Group I and II introns; Hap43-induced; rat catheter biofilm induced
orf19.2054FGR15Candida albicans SC5314Putative transcription factor with zinc finger DNA-binding motif; lacks an ortholog in S. cerevisiae; transposon mutation affects filamentous growth; caspofungin induced; mutation causes marginal increase in caspofungin sensitivity
orf19.2057Candida albicans SC5314Protein of unknown function
orf19.4740Candida albicans SC5314Protein of unknown function
orf19.1400Candida albicans SC5314Protein of unknown function
orf19.1401EAP1Candida albicans SC5314GPI-anchored cell wall adhesin; Efg1-regulated; mutant suppresses cell adhesion, filamentation, invasive growth defects of S. cerevisiae flo8 or flo11 mutant; biofilm induced; required for biofilm formation; Bcr1-repressed in a/a biofilms
orf19.4744Candida albicans SC5314Putative phosphatidylinositol 3-phosphate (PI3P) phosphatase; repressed by alpha pheromone in SpiderM medium
orf19.1403Candida albicans SC5314Protein of unknown function
orf19.1404Candida albicans SC5314Predicted tRNA dihydrouridine synthase; Spider biofilm induced
orf19.2060SOD5Candida albicans SC5314Cu and Zn-containing superoxide dismutase; protects against oxidative stress; induced by neutrophils, hyphal growth, caspofungin, osmotic/oxidative stress; oralpharyngeal candidiasis induced; rat catheter and Spider biofilm induced
Locus IdGene NameOrganismDescription
orf19.1405PHO13Candida albicans SC5314Putative 4-nitrophenylphosphatase; Hap43p-repressed gene; transcription is regulated upon yeast-hyphal switch
orf19.4748Candida albicans SC5314Putative U2B'' component of the U2 snRNP, involved in splicing; contains an RNA recognition motif (RRM); ortholog of S. cerevisiae MSL1; Hap43p-induced gene
orf19.2062SOD4Candida albicans SC5314Cu and Zn-containing superoxide dismutase; role in response to host innate immune ROS; regulated on white-opaque switch; ciclopirox olamine induced; caspofungin repressed; SOD1,4,5,6 gene family; yeast-associated; Spider biofilm induced
orf19.2063Candida albicans SC5314Protein of unknown function
orf19.1409VAC7Candida albicans SC5314Ortholog of S. cerevisiae Vac7; integral vacuolar membrane protein involved in vacuole inheritance and morphology; mutants are viable
orf19.2068Candida albicans SC5314Protein of unknown function
orf19.2069SMF3Candida albicans SC5314Putative vacuolar iron transporter; alkaline upregulated; caspofungin repressed; induced by Mnl1 under weak acid stress; Hap43-repressed
orf19.6032SPE1Candida albicans SC5314Ornithine decarboxylase; enzyme of polyamine biosynthesis; mutant is viable; functionally complements polyamine auxotrophy of S. cerevisiae spe1 mutant; downregulated upon adherence to polystyrene
orf19.6033CMP1Candida albicans SC5314Catalytic subunit of calcineurin (Ca[2+]-calmodulin-regulated S/T protein phosphatase); required for wild-type virulence, resistance to high pH, Na(+), Li(+), Mn(2+), and fluconazole tolerance; micafungin is fungicidal to null mutant
orf19.6035Candida albicans SC5314Protein of unknown function; repressed by nitric oxide
orf19.6037ASM3Candida albicans SC5314Putative secreted acid sphingomyelin phosphodiesterase; possible Kex2 substrate; transcript increased in an azole-resistant strain that overexpresses MDR1; flow model biofilm induced; F-12/CO2 early biofilm induced
orf19.6038UGA32Candida albicans SC5314Predicted Zn(II)2Cys6 transcription factor; has similarity to S. cerevisiae Uga3, a transcription factor involved in the regulation of gamma-aminobutyrate metabolism genes; rat catheter biofilm induced
orf19.6039Candida albicans SC5314Protein of unknown function
orf19.2832INN1Candida albicans SC5314Protein with similarity to S. cerevisiae Inn1p, which is an essential protein of the contractile actomyosin ring required for ingression of the plasma membrane into the bud neck during cytokinesis; contains a C2 membrane targeting domain
orf19.2833PGA34Candida albicans SC5314Putative GPI-anchored protein; transcript repressed by alpha pheromone in SpiderM medium; induced in oralpharyngeal candidasis; flow model biofilm induced; Spider biofilm induced
orf19.3490FGR6-4Candida albicans SC5314Protein lacking an ortholog in S. cerevisiae; member of a family encoded by FGR6-related genes in the RB2 repeat sequence; transposon mutation affects filamentous growth
orf19.2835Candida albicans SC5314Protein of unknown function
orf19.2836Candida albicans SC5314Protein with similarity to carbonic anhydrases
orf19.2838Candida albicans SC5314Protein of unknown function; mutation confers hypersensitivity to amphotericin B; flow model biofilm induced
orf19.2839CIRT4BCandida albicans SC5314Cirt family transposase; transcript repressed in an azole-resistant strain that overexpresses CDR1 and CDR2; Hap43-repressed; flow model biofilm induced
Locus IdGene NameOrganismDescription
orf19.3498Candida albicans SC5314Protein of unknown function
orf19.3499Candida albicans SC5314Secreted potein; Hap43-repressed; fluconazole-induced; regulated by Tsa1, Tsa1B under H2O2 stress conditions; induced by Mnl1p under weak acid stress; Spider biofilm induced
orf19.6041RPO41Candida albicans SC5314Putative mitochondrial RNA polymerase; repressed in core stress response; Spider biofilm induced
orf19.6044MOB2Candida albicans SC5314Mob1/phocein domain protein of RAM signaling network; cell wall integrity; role in cell separation, cortical actin polarization; required for hyphal growth; phosphorylated by Cdc28 on hyphal induction; activates Cbk1; mRNA binds She3
orf19.6045Candida albicans SC5314Putative phosphatidylserine decarboxylase; involved in phosphatidylethanolamine; Spider biofilm repressed
orf19.6047TUF1Candida albicans SC5314Translation elongation factor TU; macrophage/pseudohyphal-induced; repressed upon phagocytosis by murine macrophage; levels decrease in stationary phase cells; Spider biofilm repressed
orf19.7485Candida albicans SC5314Putative mitochondrial ribosomal protein of the large subunit; Hap43p-repressed gene; ortholog of S. cerevisiae MRPL9
orf19.4142Candida albicans SC5314Putative transporter; decreased transcription is observed upon fluphenazine treatment
orf19.4143FYV5Candida albicans SC5314Protein with a predicted role maturation of 18S rRNA; rat catheter biofilm induced
orf19.7487Candida albicans SC5314Protein of unknown function
orf19.7488Candida albicans SC5314Component of the SSU processome; predicted role in pre-18S rRNA processing; Spider biofilm induced
orf19.4145ZCF20Candida albicans SC5314Zn(II)2Cys6 transcription factor orthologous to S. cerevisiae Hap1; regulated by Sef1, Sfu1; Hap43-induced; Spider biofilm induced
orf19.4146SMD3Candida albicans SC5314Putative core snRNP protein; induced upon adherence to polystyrene
orf19.4148Candida albicans SC5314Protein of unknown function
orf19.4149Candida albicans SC5314Predicted protein of unknown function; overlaps orf19.4149.1
orf19.6830Candida albicans SC5314Putative enoyl-CoA hydratase; Spider biofilm induced
orf19.6831PRP5Candida albicans SC5314Putative pre-mRNA processing RNA-helicase; induced upon adherence to polystyrene; rat catheter and Spider biofilm induced
orf19.454SFL1Candida albicans SC5314Transcription factor involved in negative regulation of morphogenesis, flocculation and virulence; induced in core caspofungin response; Spider biofilm induced
orf19.7490Candida albicans SC5314Predicted membrane transporter; fucose:proton symporter family member, MFS superfamily; flow model biofilm induced
orf19.457Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.7494Candida albicans SC5314Protein of unknown function; cell-cycle regulated periodic mRNA expression
orf19.6838Candida albicans SC5314Putative protein of unknown function, transcript upregulated in clinical isolates from HIV+ patients with oral candidiasis; Spider biofilm induced
orf19.4151SPO1Candida albicans SC5314Protein similar to phospholipase B; fungal-specific (no human or murine homolog)
orf19.7495Candida albicans SC5314Protein with NADPH oxidoreductase containing flavin mononucleotide (FMN) domain; induced by nitric oxide
orf19.4152CEF3Candida albicans SC5314Translation elongation factor 3; antigenic in humans; predicted C-term nucleotide-binding active site; protein on surface of yeast, not hyphae; polystyrene adherence induced; higher protein amount in stationary phase; possibly essential
orf19.7497Candida albicans SC5314Protein of unknown function
orf19.7499Candida albicans SC5314Putative nicotinic acid mononucleotide adenylyltransferase, involved in NAD salvage pathway; Spider biofilm repressed
orf19.7501NAP1Candida albicans SC5314Nucleosome assembly protein; mutants show constitutive filamentous growth; present in exponential and stationary growth phase yeast cultures
orf19.7504Candida albicans SC5314Ortholog of S. cerevisiae Rts3; a component of the protein phosphatase type 2A complex; Plc1-regulated; induced in core caspofungin response; Spider biofilm induced
orf19.7506Candida albicans SC5314Protein of unknown function
orf19.4960Candida albicans SC5314Protein of unknown function
orf19.4962RMP1Candida albicans SC5314Ortholog of Rmp1; subunit of RNase MRP subunit that processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; rat catheter and Spider biofilm induced
orf19.4964Candida albicans SC5314Protein of unknown function
orf19.4965Candida albicans SC5314Protein of unknown function; rat catheter biofilm induced
orf19.1623CAP1Candida albicans SC5314AP-1 bZIP transcription factor; apoptotic, oxidative stress response/resistance, multidrug resistance; nuclear in oxidative stress; complements S. cerevisiae yap1 mutant; oralpharyngeal candidasis-, human neutrophil, Spider biofilm induced
orf19.2280ZCF10Candida albicans SC5314Putative transcription factor with zinc cluster DNA-binding motif
orf19.2281Candida albicans SC5314Protein of unknown function
orf19.4969KEM1Candida albicans SC53145'->3' exoribonuclease of cytoplasmic stress granules; role in filamentous growth; complements slow growth/mating of S. cerevisiae kem1 mutant; required for SD or Spider medium biofilm formation
orf19.2282Candida albicans SC5314Protein of unknown function
orf19.2283DQD1Candida albicans SC5314Putative 3-dehydroquinate dehydratase; ketoconazole-repressed; protein abundance downregulated by macrophages; flow model biofilm induced
Locus IdGene NameOrganismDescription
orf19.1628LAP41Candida albicans SC5314Putative aminopeptidase yscI precursor; mutant is viable; protein present in exponential and stationary growth phase yeast cultures; Spider biofilm repressed
orf19.2285Candida albicans SC5314Protein of unknown function; transcription induced by benomyl treatment
orf19.2287RPA12Candida albicans SC5314Putative DNA-directed RNA polymerase I; induced upon adherence to polystyrene
orf19.2289ARP3Candida albicans SC5314Protein with Myo5p-dependent localization to cortical actin patches at hyphal tip; mutation confers hypersensitivity to cytochalasin D; Spider biofilm repressed
orf19.7510KIN2Candida albicans SC5314Protein with similarity to S. cerevisiae Kin2p, transcription is positively regulated by Tbf1
orf19.7512Candida albicans SC5314Protein of unknown function
orf19.7513ALK2Candida albicans SC5314N-Alkane inducible cytochrome P450
orf19.7514PCK1Candida albicans SC5314Phosphoenolpyruvate carboxykinase; glucose, C-source, yeast-hypha, Hap43 regulated; fluconazole, phagocytosis, H2O2, oral candidasis, Spider/rat catheter/flow model biofilm induced; repressed in biofilm by Bcr1, Tec1, Ndt80, Rob1, Brg1
orf19.4751Candida albicans SC5314Protein of unknown function
orf19.4753PFK26Candida albicans SC5314Putative 6-phosphofructo-2-kinase; protein repressed during the mating process
orf19.1411Candida albicans SC5314Putative cytochrome P450; Hap43-repressed gene
orf19.1412Candida albicans SC5314Protein of unknown function
orf19.1413YFH1Candida albicans SC5314Frataxin; may be required for iron storage or delivery; role in oxidative stress resistance; transcript regulated by Nrg1, repressed if iron absent induced by macrophage interaction; Hap43-repressed gene
orf19.4756Candida albicans SC5314Protein of unknown function
orf19.2070Candida albicans SC5314Protein of unknown function
orf19.1415FRE10Candida albicans SC5314Major cell-surface ferric reductase under low-iron conditions; 7 transmembrane regions and a secretion signal predicted; Tup1, Rim101, Ssn6, Hog1, caspofungin repressed; ciclopirox olamine induced; rat catheter biofilm induced
orf19.4758Candida albicans SC5314Putative reductase or dehydrogenase; Hap43-repressed gene; alkaline repressed
orf19.4759COX5Candida albicans SC5314Cytochrome oxidase subunit V; putative upstream CCAAT box regulatory element; macrophage/pseudohyphal-induced; repressed by nitric oxide; intron in 5'-UTR; Hap43p-dependent repression in low iron medium
orf19.2073Candida albicans SC5314Protein with a multidrug and toxin extrusion protein domain; induced by Mnl1 under weak acid stress
orf19.1418SEC15Candida albicans SC5314Predicted exocyst subunit; cellular bud tip-associated protein; ortholog of S. cerevisiae SEC15
Locus IdGene NameOrganismDescription
orf19.2076Candida albicans SC5314Protein of unknown function; S. pombe ortholog SPAC7D4.05 encodes a predicted hydrolase; Hap43-repressed; Spider biofilm induced
orf19.2079PHHBCandida albicans SC5314Putative 4a-hydroxytetrahydrobiopterin dehydratase; transposon mutation affects filamentous growth; flow model biofilm induced; Spider biofilm induced
orf19.7301Candida albicans SC5314Protein of unknown function
orf19.7303Candida albicans SC5314Protein of unknown function
orf19.7304Candida albicans SC5314Protein of unknown function; Hap43-induced; transcript induced early in infection of reconstituted human epithelium, while expression of the C. dubliniensis ortholog is not upregulated; mutants are viable; rat catheter biofilm repressed
orf19.7306Candida albicans SC5314Aldo-keto reductase; increased transcript associated with MDR1 overexpression, benomyl or long-term fluconazole treatment; overexpression does not affect drug or oxidative stress sensitivity; stationary phase enriched; flow biofim repressed
orf19.7307Candida albicans SC5314Putative oxidoreductase; similar to S. cerevisiae Pga3p; possible Kex2p substrate
orf19.7308TUB1Candida albicans SC5314Alpha-tubulin; gene has intron; complements cold-sensitivity of S. cerevisiae tub1 mutant; C. albicans has single alpha-tubulin gene, whereas S. cerevisiae has two (TUB1, TUB3); farnesol-upregulated in biofilm; sumoylation target
orf19.2841PGM2Candida albicans SC5314Ortholog of S. cerevisiae Pgm2; induced in planktonic culture; Tye7p-regulated; flow model biofilm induced; rat catheter biofilm repressed
orf19.2842GZF3Candida albicans SC5314GATA-type transcription factor; oxidative stress-induced via Cap1; mutant has abnormal colony morphology and altered sensitivity to fluconazole, LiCl, and copper; Spider biofilm induced
orf19.2843RHO1Candida albicans SC5314Small GTPase of Rho family; regulates beta-1,3-glucan synthesis activity and binds Gsc1p; essential; expected to be geranylgeranylated by geranylgeranyltransferase type I; plasma membrane-localized
orf19.2844APL4Candida albicans SC5314Predicted gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; that binds clathrin and is involved in vesicle mediated transport; induced in core caspofungin response; rat catheter biofilm repressed
orf19.2847Candida albicans SC5314Protein of unknown function
orf19.2848Candida albicans SC5314Predicted regulatory subunit of the Atg1 signaling complex; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; Spider biofilm induced
orf19.2849AQY1Candida albicans SC5314Aquaporin water channel; osmotic shock resistance, WT freeze tolerance; virulent in mice; flucytosine repressed; flow model/RPMI/Spider/rat catheter biofilm induced; required for RPMI biofilm formation; Bcr1-induced in a/a RPMI biofilms
orf19.6052CNS1Candida albicans SC5314Putative co-chaperone; Hap43p-induced gene; mutation confers hypersensitivity to radicicol
orf19.6053CIS2Candida albicans SC5314Putative role in regulation of biogenesis of the cell wall; upregulated in biofilm; Gcn4p-regulated
orf19.6055Candida albicans SC5314Protein of unknown function
orf19.6056Candida albicans SC5314Protein of unknown function
orf19.6058GLO1Candida albicans SC5314Putative monomeric glyoxalase I; oxidative stress-induced via Cap1; flow model and rat catheter biofilm repressed
Locus IdGene NameOrganismDescription
orf19.2850Candida albicans SC5314Protein of unknown function; induced by nitric oxide independent of Yhb1p
orf19.2851Candida albicans SC5314Putative ornithine transport protein; localized to the mitochondrial membrane
orf19.2853Candida albicans SC5314Protein of unknown function; rat catheter biofilm induced
orf19.2859SRP40Candida albicans SC5314Putative chaperone of small nucleolar ribonucleoprotein particles; macrophage/pseudohyphal-induced; rat catheter biofilm induced
orf19.5404Candida albicans SC5314Putative cell wall mannoprotein; repressed during the mating process; merged with orf19.5401 into orf19.5404.1; Spider biofilm induced
orf19.6062Candida albicans SC5314Putative TIM23 translocase complex subunit; membrane-localized; Hap43-repressed
orf19.6063UBP6Candida albicans SC5314Putative ubiquitin-specific protease of the 26S proteasome; oxidative stress-induced via Cap1p
orf19.5407SOF1Candida albicans SC5314Putative protein with a predicted role in 40S ribosomal subunit biogenesis; rat catheter biofilm induced
orf19.5408HRK1Candida albicans SC5314Putative serine/threonine kinase; predicted role in cellular ion homeostasis; Spider biofilm repressed
orf19.5409IST1Candida albicans SC5314Protein with a positive role in the multivesicular body sorting pathway; rat catheter biofilm repressed
orf19.4159Candida albicans SC5314Protein of unknown function
orf19.6840Candida albicans SC5314Protein of unknown function; transcript detected in high-resolution tiling arrays; transcription induced by alpha pheromone in SpiderM medium; Spider and early-stage flow model biofilm induced
orf19.6842TUS1Candida albicans SC5314Putative guanine nucleotide exchange factor; induced by Mnl1 under weak acid stress; Spider biofilm induced
orf19.6844ICL1Candida albicans SC5314Isocitrate lyase; glyoxylate cycle enzyme; required for virulence in mice; induced upon phagocytosis by macrophage; farnesol regulated; Pex5-dependent peroxisomal localization; stationary phase enriched; rat catheter, Spider biofilm induced
orf19.465IFF9Candida albicans SC5314Predicted GPI-linked cell-wall protein; similar to Hyr1; induced in low iron; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.6845Candida albicans SC5314Putative transcription factor with bZIP DNA-binding motif; rat catheter biofilm induced
orf19.6847Candida albicans SC5314Putative tRNA U44 2'-O-methyltransferase; virulence-group-correlated expression; induced during oral infection; mutants have reduced ability to damage oral epithelial cells; early-stage flow model biofilm induced
orf19.467WOR3Candida albicans SC5314Transcription factor; modulator of white-opaque switch; induced in opaque cells; promoter bound by Wor1; overexpression at 25 degr shifts cells to opaque state; deletion stabilizes opaque cells at higher temperatures; Spider biofilm induced
orf19.3504RPL23ACandida albicans SC5314Ribosomal protein; downregulated upon phagocytosis by murine macrophage; Hap43-induced; sumoylation target; Spider biofilm repressed
orf19.4160Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.6848VPS16Candida albicans SC5314Protein similar to S. cerevisiae Vps16p, which is involved in protein-vacuolar targeting; likely to be essential for growth, based on insertional mutagenesis; downregulated in biofilm or in azole-resistant strain that overexpresses MDR1
orf19.3505Candida albicans SC5314Protein of unknown function
orf19.469HST7Candida albicans SC5314MAP kinase kinase involved in mating and hyphal growth signal transduction pathways; phosphorylates Cek1p; wild-type virulence in mouse systemic infection; functional homolog of S. cerevisiae Ste7p; mutants are hypersensitive to caspofungin
orf19.3506DBR1Candida albicans SC5314Debranchase; homozygous mutant accumulates lariat intermediates of mRNA splicing; rat catheter biofilm repressed
orf19.4162MLH1Candida albicans SC5314Putative mismatch repair protein; cell-cycle regulated periodic mRNA expression
orf19.4163Candida albicans SC5314Protein of unknown function
orf19.3508Candida albicans SC5314Putative protein of unknown function; stationary phase enriched protein
orf19.4167Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.4168Candida albicans SC5314Protein of unknown function
orf19.7517CHT1Candida albicans SC5314Chitinase; putative N-terminal catalytic domain; has secretory signal sequence; lacks S/T region and N-glycosylation motifs of Chs2p and Chs3p; alkaline downregulated; expression not detected in yeast-form or hyphal cells
orf19.7518ZCF38Candida albicans SC5314Putative Zn(II)2Cys6 transcription factor
orf19.4972Candida albicans SC5314Putative transcription factor with zinc finger DNA-binding motif
orf19.1631ERG6Candida albicans SC5314Delta(24)-sterol C-methyltransferase, converts zymosterol to fecosterol, ergosterol biosynthesis; mutation confers nystatin resistance; Hap43, GlcNAc-, fluconazole-induced; upregulated in azole-resistant strain; Spider biofilm repressed
orf19.4975HYR1Candida albicans SC5314GPI-anchored hyphal cell wall protein; macrophage-induced; repressed by neutrophils; resistance to killing by neutrophils, azoles; regulated by Rfg1, Efg1, Nrg1, Tup1, Cyr1, Bcr1, Hap43; Spider and flow model biofilm induced
orf19.4976Candida albicans SC5314Protein of unknown function
orf19.1633UTP4Candida albicans SC5314Putative U3 snoRNA-associated protein; Hap43-induced; physically interacts with TAP-tagged Nop1; Spider biofilm induced
orf19.2290TOR1Candida albicans SC5314Protein similar to TOR family phosphatidylinositol kinases; mutation confers resistance to rapamycin; involved in regulation of ribosome biogenesis, starvation response, and adhesion
orf19.1634Candida albicans SC5314Protein of unknown function
orf19.1635RPL12Candida albicans SC5314Ribosomal protein L12, 60S ribosomal subunit; downregulated by human whole blood or polymorphonuclear cells; genes encoding cytoplasmic ribosomal subunits are downregulated upon phagocytosis by macrophage; Tbf1p-activated; Hap43p-induced
orf19.4979KNS1Candida albicans SC5314Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway, phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; Spider and flow model biofilm induced
Locus IdGene NameOrganismDescription
orf19.1636STE50Candida albicans SC5314Protein with sterile alpha motif (SAM) and Ras-associated domain (RAD); similar to S. cerevisiae Rad50p, which is involved in signal transduction via interaction with and regulation of MAPKKK
orf19.1637Candida albicans SC5314Protein of unknown function
orf19.1638Candida albicans SC5314Protein of unknown function
orf19.1639Candida albicans SC5314Protein of unknown function
orf19.2297ARL3Candida albicans SC5314Putative Ras superfamily GTPase; induced by nitric oxide independent of Yhb1p
orf19.2298WBP1Candida albicans SC5314Putative oligosaccharyltransferase subunit; Spider biofilm repressed
orf19.2299Candida albicans SC5314Protein of unknown function
orf19.7520POT1Candida albicans SC5314Putative peroxisomal 3-oxoacyl CoA thiolase; transcript regulated by Nrg1 and Mig1; farnesol regulated; Hap43-repressed
orf19.4760Candida albicans SC5314Putative protein-histidine N-methyltransferase; Spider biofilm induced
orf19.4761HST1Candida albicans SC5314Putative histone deacetylase, involved in regulation of white-opaque switching
orf19.1420Candida albicans SC5314Protein of unknown function
orf19.1421Candida albicans SC5314Protein of unknown function
orf19.1422FZO1Candida albicans SC5314Mitochondrial biogenesis protein; rat catheter and Spider biofilm induced
orf19.4765PGA6Candida albicans SC5314GPI-anchored cell wall adhesin-like protein; induced by high iron; upregulated upon Als2 depletion; mRNA binds She3 and is localized to hyphal tips; Spider biofilm repressed
orf19.1424Candida albicans SC5314Predicted membrane transporter, member of the oxalate:formate antiporter (OFA) family, major facilitator superfamily (MFS)
orf19.2081POM152Candida albicans SC5314Putative nuclear pore membrane glycoprotein
orf19.4768Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.1427Candida albicans SC5314Putative transporter; fungal-specific; Spider biofilm induced
orf19.2084CDH1Candida albicans SC5314Protein involved in regulation of mitosis; similar to S. cerevisiae Cdh1, which is an APC/C component; transcriptionally induced by Mnl1 under weak acid stress
orf19.1429SOH1Candida albicans SC5314Subunit of the RNA polymerase II mediator complex; involved in control of cytokinesis, morphogenesis, biofilm formation, virulence; cell-cycle regulated periodic mRNA expression
Locus IdGene NameOrganismDescription
orf19.2088DPB4Candida albicans SC5314Putative DNA polymerase epsilon subunit D; null mutant is viable but slow-growing and displays abnormal invasive growth on SD and YPD media; Spider biofilm repressed
orf19.7311Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.7312ERG13Candida albicans SC53143-hydroxy-3-methylglutaryl coenzyme A synthase; ergosterol biosynthesis; sumoylation target; Tn mutation affects filamentation; amphotericin B, caspofungin repressed; exponential, stationary growth phase expressed; Spider biofilm repressed
orf19.7313SSU1Candida albicans SC5314Protein similar to S. cerevisiae Ssu1 sulfite transport protein; Tn mutation affects filamentous growth; regulated by Gcn2 and Gcn4; induced by nitric oxide; Hap43-repressed; Spider and flow model biofilm induced
orf19.7317UGA33Candida albicans SC5314Zinc-finger transcription factor; similar to S. cerevisiae Uga3 which regulates gamma-aminobutyrate metabolism gene expression; required for yeast cell adherence to silicone substrate; rat catheter biofilm induced
orf19.7319SUC1Candida albicans SC5314Zinc-finger transcription factor; regulates alpha-glucosidase exression; complements S. cerevisiae suc2 for sucrose utilization and mal13 maltase defect; required for yeast cell adherence to silicone substrate; rat catheter biofilm induced
orf19.4772SSU81Candida albicans SC5314Predicted adaptor protein involved in activation of MAP kinase-dependent signaling pathways; links response to oxidative stress to morphogenesis and cell wall biosynthesis; caspofungin repressed
orf19.4774AOX1Candida albicans SC5314Alternative oxidase; low abundance; constitutively expressed; one of two isoforms (Aox1p and Aox2p); involved in a cyanide-resistant respiratory pathway present in plants, protists, and some fungi, absent in S. cerevisiae; Hap43p-repressed
orf19.6066Candida albicans SC5314Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; Spider biofilm induced
orf19.2862RIB1Candida albicans SC5314Putative GTP cyclohydrolase II; enzyme of riboflavin biosynthesis; fungal-specific (no human or murine homolog); regulated by Sef1p-, Sfu1p-, and Hap43p
orf19.2866Candida albicans SC5314Protein of unknown function
orf19.2867Candida albicans SC5314Protein of unknown function
orf19.5410Candida albicans SC5314Protein of unknown function
orf19.5412Candida albicans SC5314Protein of unknown function
orf19.6070ENA2Candida albicans SC5314Putative sodium transporter; induced by ciclopirox olamine; alkaline induced by Rim101; repressed by high-level peroxide stress; induced in oral candidiasis clinical isolates; possibly essential gene; rat catheter and Spider biofilm induced
orf19.6071Candida albicans SC5314Protein of unknown function
orf19.5416ESA1Candida albicans SC5314Subunit of the NuA4 histone acetyltransferase complex; member of MYST family; Spider biofilm induced
orf19.5417DOT5Candida albicans SC5314Putative nuclear thiol peroxidase; alkaline downregulated; sumoylation target; Spider and flow model biofilm induced
orf19.6074HBR1Candida albicans SC5314Essential protein involved in regulation of MTL gene expression; hemoglobin-regulated inhibitor of white-opaque switching, may affect survival in host; activator of MTLalpha1 and MTLalpha2; transcript activated by hemoglobin
orf19.6076Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.6078POL93Candida albicans SC5314Predicted ORF in retrotransposon Tca8 with similarity to the Pol region of retrotransposons encoding reverse transcriptase, protease and integrase; downregulated in response to ciclopirox olamine; F-12/CO2 early biofilm induced
orf19.2870Candida albicans SC5314Protein of unknown function; rat catheter and Spider biofilm induced
orf19.6079Candida albicans SC5314Predicted ORF in retrotransposon Tca8 with similarity to the Gag region encoding nucleocapsid-like protein; repressed by ciclopirox olamine; filament induced; regulated by Rfg1, Tup1; overlaps orf19.6078.1
orf19.2873TOP2Candida albicans SC5314DNA topoisomerase II; catalyzes ATP-dependent DNA relaxation and decatenation in vitro; Y842 predicted to be catalytic; functional homolog of S. cerevisiae Top2p; sensitive to amsacrine or doxorubicin; farnesol-upregulated in biofilm
orf19.2876CBF1Candida albicans SC5314Transcription factor; binds ribosomal protein gene promoters and rDNA locus with Tbf1; regulates sulfur starvation-response, respiratory, glycolytic genes; does not bind to centromeres as does S. cerevisiae Cbf1; Spider biofilm repressed
orf19.2879IFF5Candida albicans SC5314Putative GPI-anchored protein; adhesin-like protein; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.5422Candida albicans SC5314Protein of unknown function
orf19.470Candida albicans SC5314Protein of unknown function
orf19.6851CHL4Candida albicans SC5314Protein described as having role in chromosome segregation; RNA abundance regulated by tyrosol and cell density
orf19.6852Candida albicans SC5314Ortholog of Rmd6 involved in S. cerevisiae sporulation; flow model biofilm induced
orf19.6853Candida albicans SC5314Protein of unknown function; Spider biofilm repressed
orf19.3510Candida albicans SC5314Predicted ORF in Assemblies 19 and 20; identical to orf19.5284; merged with orf19.5284 in Assembly 20 (see Locus History)
orf19.6854ATP1Candida albicans SC5314ATP synthase alpha subunit; antigenic in human/mouse; at hyphal surface; ciclopirox, ketoconazole, flucytosine induced; Efg1, caspofungin repressed; may be essential; sumoylation target; stationary phase-enriched; Spider biofilm repressed
orf19.6855Candida albicans SC5314Protein of unknown function
orf19.477Candida albicans SC5314Protein of unknown function
orf19.4170CSP2Candida albicans SC5314Putative cell wall associated protein; C. albicans and C. dubliniensis specific gene highly induced during chlamydospore development in both species; localized to chlamydospore cell wall; Hap43-repressed; Spider biofilm induced
orf19.478Candida albicans SC5314Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; plays a role in autophagy, protein targeting to vacuole and vesicle docking; flow model biofilm induced
orf19.4171Candida albicans SC5314Protein of unknown function
orf19.4172Candida albicans SC5314Protein of unknown function
orf19.4173Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.3518Candida albicans SC5314Protein of unknown function
orf19.3519SUA72Candida albicans SC5314Predicted transcription factor; induced during planktonic growth, whereas related SUA71 is downregulated
orf19.4175TOK1Candida albicans SC5314Outwardly rectifying, noisily gated potassium channel; modulates sensitivity to human salivary histatin (Hst5); very similar to S. cerevisiae Tok1p; Bcr1-repressed in RPMI a/a biofilms
orf19.4177HIS5Candida albicans SC5314Putative histidinol-phosphate aminotransferase; Gcn4p-regulated; protein present in exponential and stationary growth phase yeast cultures
orf19.480Candida albicans SC5314Protein of unknown function; rat catheter and Spider biofilm induced
orf19.6861Candida albicans SC5314Protein of unknown function
orf19.529Candida albicans SC5314Protein of unknown function
orf19.4222SST2Candida albicans SC5314Predicted regulator of G-protein signaling in mating pathway; null mutation causes alpha-factor hypersensitivity and mating defect (in opaque MTLa/MTLa background); transcript induced by alpha factor
orf19.7568Candida albicans SC5314Protein of unknown function
orf19.4227Candida albicans SC5314Protein of unknown function
orf19.4229Candida albicans SC5314Putative polyphosphate phosphatase; role in hydrolysis of diphosphorylated inositol polyphosphates and diadenosine polyphosphates; Spider biofilm induced
orf19.1681Candida albicans SC5314Protein of unknown function
orf19.1683PPH21Candida albicans SC5314Putative protein phosphatase of the Type 2A-related family (serine/threonine-specific), similar to S. cerevisiae Pph21p; caspofungin repressed; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.1686Candida albicans SC5314Protein of unknown function
orf19.530Candida albicans SC5314Protein with a UV radiation resistance protein/autophagy-related protein 14 domain; Hap43p-induced gene; mutants are viable
orf19.4232PTH1Candida albicans SC5314Putative gluconate transport protein; antigenic during human oral infection; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.4233THR4Candida albicans SC5314Putative threonine synthase; protein present in exponential and stationary growth phase yeast cultures; Gcn4p-regulated; sumoylation target
orf19.7578Candida albicans SC5314Protein of unknown function
orf19.4236RET2Candida albicans SC5314Delta subunit of the coatomer complex (COPI); coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER; interacts with Crk1 in the two-hybrid system; Spider biofilm repressed
orf19.1690TOS1Candida albicans SC5314Protein similar to alpha agglutinin anchor subunit; secreted; exogenously expressed protein is a substrate for Kex2 processing in vitro; fluconazole-induced; induced by alpha pheromone in SpiderM medium; Hap43-induced
Locus IdGene NameOrganismDescription
orf19.1693CAS4Candida albicans SC5314RAM cell wall integrity signaling network protein; cell separation, azole sensitivity; needed for hyphal growth; insertion mutation near 3' end of gene increases caspofungin sensitivity; pheromone/hyphal induced; flow biofilm repressed
orf19.3010.1ECM33Candida albicans SC5314GPI-anchored cell wall protein; mutants show cell-wall defects and reduced adhesion, host cell damage, and endocytosis; mutant infection is immunoprotective in murine model; fluconazole-induced; caspofungin repressed
orf19.1699BZZ1Candida albicans SC5314Protein similar to S. cerevisiae Bzz1p, which is an SH3 domain protein involved in the regulation of actin polymerization
orf19.6920Candida albicans SC5314Protein of unknown function; induced during chlamydospore formation in both C. albicans and C. dubliniensis; Hap43-induced gene; Spider biofilm induced; F-12/CO2 early biofilm induced
orf19.542HXK2Candida albicans SC5314Hexokinase II; antigenic in humans; repressed by human neutrophils; Efg1-regulated; fluconazole-induced; gene regulation by Ssn6; present in exponential and stationary growth phase; flow model biofilm induced; Spider biofilm repressed
orf19.1433Candida albicans SC5314Protein of unknown function; Hap43-repressed; colony morphology-related gene regulation by Ssn6; Spider biofilm induced
orf19.1434Candida albicans SC5314Protein of unknown function
orf19.2090Candida albicans SC5314Ortholog of S. cerevisiae Ecm16, an essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP required for 18S rRNA synthesis; Hap43-induced; Spider biofilm induced
orf19.1435TEF1Candida albicans SC5314Translation elongation factor 1-alpha; at cell surface; binds human plasminogen; macrophage/pseudohyphal-induced; induced in RHE model of oral candidiasis, in clinical oral candidiasis isolates; possibly essential; Spider biofilm repressed
orf19.4778LYS142Candida albicans SC5314Zn(II)2Cys6 transcription factor; has similarity to S. cerevisiae Lys14, involved in the regulation of lysine biosynthesis genes; fungal-specific
orf19.2092Candida albicans SC5314Putative peroxisomal cystathionine beta-lyase; Gcn4p-regulated
orf19.2093RFA1Candida albicans SC5314Putative DNA replication factor A; RNA abundance regulated by cell cycle, tyrosol and cell density
orf19.2095Candida albicans SC5314Protein of unknown function
orf19.2097Candida albicans SC5314Predicted DNA-dependent ATPase/helicase; Spider biofilm induced
orf19.2099HIR1Candida albicans SC5314Component of the HIR complex, a nucleosome assembly factor involved in chromatin formation; involved in regulation of white-opaque switching frequency
orf19.7323CBP1Candida albicans SC5314Corticosteroid binding protein; transcription induced at late log-phase or upon adherence to polystyrene; not induced by corticosterone; contains a possible NAD/FAD binding region; regulated by Nrg1, Tup1; Spider biofilm induced
orf19.7324THI13Candida albicans SC5314Thiamin pyrimidine synthase; synthesis of the thiamine precursor hydroxymethylpyrimidine phosphate; single-turnover enzyme that provides histidine for HMP-P formation; induced by nitric oxide independent of Yhb1; Spider biofilm induced
orf19.7326Candida albicans SC5314Protein of unknown function
orf19.7327PHO88Candida albicans SC5314Protein with a role in phosphate transport; biofilm-regulated expression; amphotericin B repressed
orf19.7328Candida albicans SC5314Protein with a Staphylococcal nuclease domain; transcript regulated by Mig1 and Tup1; flow model and Spider biofilm repressed
Locus IdGene NameOrganismDescription
orf19.4780Candida albicans SC5314Predicted MFS family membrane transporter, member of the drug:proton antiporter (12 spanner) (DHA1) family; Spider biofilm induced
orf19.4781GRP1Candida albicans SC5314Protein similar to dihydroflavonol-4-reductases
orf19.1441Candida albicans SC5314Protein of unknown function
orf19.4784CRP1Candida albicans SC5314Copper transporter; CPx P1-type ATPase; mediates Cu resistance; similar to Menkes and Wilson disease proteins; copper-induced; Tbf1-activated; suppresses Cu sensitivity of S. cerevisiae cup1 mutant; flow model biofilm induced
orf19.1442PLB4.5Candida albicans SC5314Phospholipase B; Hog1-induced; regulated by Ssn6; putative GPI-anchor; repressed during cell wall regeneration; clade-associated gene expression; Hap43-induced; rat catheter and Spider biofilm repressed
orf19.5423EST3Candida albicans SC5314Telomerase subunit; required for telomere maintenance in vivo; separable roles in telomerase activity and processivity; not required for catalytic activity in vitro; related to mammalian Tpp1p
orf19.6081PHR2Candida albicans SC5314Glycosidase; role in vaginal not systemic infection (low pH not neutral); low pH, high iron, fluconazole, Hap43-induced; Rim101-repressed at pH8; rat catheter biofilm induced; Bcr1-repressed in RPMI a/a biofilms
orf19.6082Candida albicans SC5314Protein of unknown function
orf19.6083Candida albicans SC5314Protein of unknown function
orf19.6084Candida albicans SC5314Protein of unknown function; flow model biofilm induced; Spider biofilm induced
orf19.5428Candida albicans SC5314Putative Golgi membrane protein with a predicted role in manganese homeostasis; Hap43p-repressed gene; clade-associated gene expression
orf19.6085RPL16ACandida albicans SC5314Ribosomal protein; transposon mutation affects filamentous growth; repressed upon phagocytosis by murine macrophages; Hap43-induced; Spider biofilm repressed
orf19.5429Candida albicans SC5314Protein of unknown function
orf19.6086LEU4Candida albicans SC5314Putative 2-isopropylmalate synthase; regulated by Nrg1, Mig1, Tup1, Gcn4; induced by human whole blood or PMNs; macrophage/pseudohyphal-repressed after 16h; Spider biofilm repressed
orf19.2881MNN4Candida albicans SC5314Regulator of mannosylphosphorylation of N-linked mannans to cell wall proteins; no role in virulence or normal interaction with macrophages; mutant induces inflammatory cytokines in dendritic cells; rat catheter and Spider biofilm induced
orf19.2882XUT1Candida albicans SC5314Putative high-affinity, high-capacity xanthine-uric acid/H+ symporter; similar to A. nidulans UapA; member of the Nucleobase-Ascorbate Transporter/Nucleobase-Cation Symporter (NAT/NCS2) family; rat catheter biofilm induced
orf19.2884CDC68Candida albicans SC5314Functional homolog of S. cerevisiae Cdc68, a transcription elongation factor; essential; possible drug target
orf19.2885PRI2Candida albicans SC5314Putative DNA primase; gene adjacent to and divergently transcribed with CDC68; Hap43-induced; Spider biofilm repressed
orf19.2886CEK1Candida albicans SC5314ERK-family protein kinase; required for wild-type yeast-hypha switch, mating efficiency, virulence in mice; Cst20-Hst7-Cek1-Cph1 MAPK pathway regulates mating, and invasive hyphal growth under some conditions; Spider biofilm induced
orf19.2887Candida albicans SC5314Ortholog in S. cerevisiae is localizedto the bud, mating projection tip, and associates with ribosomes; Spider biofilm induced
Locus IdGene NameOrganismDescription
orf19.2888Candida albicans SC5314Protein of unknown function
orf19.2889Candida albicans SC5314Protein of unknown function
orf19.5431Candida albicans SC5314Protein of unknown function; Hap43-repressed; Spider biofilm induced
orf19.5432TPT1Candida albicans SC5314tRNA 2'-phosphotransferase; enzyme of tRNA splicing; functionally complements viability of S. cerevisiae tpt1 null mutant
orf19.6092KEL1Candida albicans SC5314Kelch repeat domain-containing protein; localizes to sites of polarized growth; mutant colonies exhibit slightly decreased filamentation ratio; not required for buccal epithelial cell adherence or virulence in mice
orf19.5437RHR2Candida albicans SC5314Glycerol 3-phosphatase; roles in osmotic tolerance, glycerol accumulation in response to salt; Spider/flow model biofilm induced; regulated by macrophage, stress, yeast-hyphal switch, pheromone, Gcn4, Hog1, Nrg1, Tup1
orf19.6862Candida albicans SC5314Hap43-induced gene; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine)
orf19.484MRPL40Candida albicans SC5314Putative mitochondrial ribosomal protein; Spider biofilm repressed
orf19.3521ARH2Candida albicans SC5314Putative adrenodoxin-NADPH oxidoreductase; role in heme biosynthesis
orf19.486NIP100Candida albicans SC5314p150 subunit of dynactin; required for normal spindle formation and position
orf19.6867Candida albicans SC5314Protein with a predicted cytochrome b5-like heme/steroid binding domain; repressed by alpha pheromone in SpiderM medium
orf19.488MEX67Candida albicans SC5314Nuclear export protein; has NTF2-like domain; interacts with Mtr2p via the NTF2-like domain
orf19.6869Candida albicans SC5314Putative lipid raft associated protein; Spider biofilm induced
orf19.489DAP1Candida albicans SC5314Similar to mammalian membrane-associated progesterone receptors involved in DNA damage response; induced in core stress response; Hog1 regulated; clade-associated expression; Hap43-repressed
orf19.3526ITR1Candida albicans SC5314MFS inositol transporter; uptake of exogenous inositol; 12 transmembrane motifs; expressed in rich medium; fluconazole, caspofungin repressed; possibly essential (UAU1 method); flow model, rat catheter and Spider biofilm induced
orf19.4182Candida albicans SC5314Protein of unknown function
orf19.3527CYT1Candida albicans SC5314Cytochrome c1; induced in high iron; alkaline repressed; possibly an essential gene, disruptants not obtained by UAU1 method; Hap43-repressed; Spider biofilm repressed
orf19.4183MUC1Candida albicans SC5314Protein similar to S. cerevisiae Muc1; a cell surface glycoprotein involved in filamentous growth; repressed by benomyl treatment; mutant is viable
orf19.3528Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.4184Candida albicans SC5314Protein with a predicted role in clathrin cage assembly; Hap43-repressed; Spider biofilm repressed
Locus IdGene NameOrganismDescription
orf19.3529ABP2Candida albicans SC5314Putative alpha-actinin-like protein; induced by alpha pheromone in SpiderM medium
orf19.4185Candida albicans SC5314Protein of unknown function
orf19.4186PCT1Candida albicans SC5314Putative choline-phosphate cytidylyl transferase, antigenic during human oral infection
orf19.4187Candida albicans SC5314Protein of unknown function
orf19.4188NMD5Candida albicans SC5314Karyopherin; carrier protein involved in nuclear import of proteins; repressed in core stress response; Hap43-induced; Spider biofilm induced
orf19.4189Candida albicans SC5314Protein of unknown function
orf19.491Candida albicans SC5314Endoplasmic reticulum (ER) protein-translocation complex subunit
orf19.492ADE17Candida albicans SC53145-Aminoimidazole-4-carboxamide ribotide transformylase, enzyme of adenine biosynthesis; antigenic in human; soluble protein in hyphae; not induced during GCN response, in contrast to the S. cerevisiae ortholog
orf19.543FUM11Candida albicans SC5314Fumarate hydratase; induced in high iron; protein in exponential and stationary-phase yeast cells, but higher in stationary phase; rat catheter biofilm repressed
orf19.4195.1FCA1Candida albicans SC5314Cytosine deaminase; enzyme of pyrimidine salvage; functional homolog of S. cerevisiae Fcy1p; mutation is associated with resistance to flucytosine (5-FC) in a clinical isolate; hyphal downregulated; gene has intron
orf19.7581Candida albicans SC5314Protein with a predicted role in assembly of U2 snRNP into the spliceosome; Spider biofilm induced
orf19.6926CSC25Candida albicans SC5314Guanyl-nucleotide exchange factor; activator of Ras/adenylyl cyclase pathway; functional homolog of S. cerevisiae Cdc25p; commonly called Cdc25; transposon mutation affects filamentous growth
orf19.6927PEP8Candida albicans SC5314Protein similar to S. cerevisiae Pep8p, which is involved in retrograde transport; transposon mutation affects filamentous growth
orf19.4241Candida albicans SC5314Protein of unknown function; transcript detected on high-resolution tiling arrays
orf19.6929Candida albicans SC5314Protein of unknown function
orf19.549Candida albicans SC5314Protein of unknown function
orf19.4244Candida albicans SC5314Protein of unknown function
orf19.4246Candida albicans SC5314Protein with similarity to S. cerevisiae Ykr070w; Tn mutation affects filamentation; Hog1-repressed; colony morphology-related gene regulation by Ssn6p; induced during cell wall regeneration; possibly essential
orf19.4248Candida albicans SC5314Ortholog of S. cerevisiae YLR118C (alias Apt1); acyl-protein thioesterase responsible for depalmitoylation of Gpa1 in S. cerevisiae; regulated by Gcn4; repressed in response to amino acid starvation (3AT); rat catheter biofilm repressed
orf19.551Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.552Candida albicans SC5314Ortholog of a S. cerevisiae Atg22; a vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.1789.1LYS1Candida albicans SC5314Saccharopine dehydrogenase (biosynthetic); enzyme of alpha-aminoadipate lysine biosynthesis pathway; functionally complements S. cerevisiae lys1 mutation; fungal-specific (no human or murine homolog)
orf19.5342.1MTR2Candida albicans SC5314Nuclear export protein; member of NTF2 family; monomeric in solution; interacts with Mex67p via the NTF2-like domain
orf19.2158NAG3Candida albicans SC5314Putative MFS transporter; similar to Nag4; required for wild-type mouse virulence and cycloheximide resistance; in gene cluster that includes genes encoding enzymes of GlcNAc catabolism; Spider biofilm repressed
orf19.513Candida albicans SC5314Protein with a DNA-binding domain, similar to S. cerevisiae meiosis-specific transcription factor Ndt80p
orf19.519Candida albicans SC5314Protein of unknown function
orf19.4785PTC1Candida albicans SC5314Putative protein phosphatase of the Type 2C-related family (serine/threonine-specific), similar to S. cerevisiae Ptc1p; mutant shows virulence defect
orf19.1444Candida albicans SC5314Protein of unknown function
orf19.4787Candida albicans SC5314Protein of unknown function
orf19.1445ESC4Candida albicans SC5314Protein similar to S. cerevisiae Esc4; a protein that represses transposition; transposon mutation affects filamentation; rat catheter biofilm repressed
orf19.4788ARG5,6Candida albicans SC5314Arginine biosynthetic enzyme; processed in S. cerevisiae into 2 polypeptides with acetylglutamate kinase (Arg6) activity and acetylglutamate-phosphate reductase (Arg5) activity; Gcn4 regulated; alkaline repressed; Spider biofilm induced
orf19.4789Candida albicans SC5314Protein of unknown function
orf19.1448APT1Candida albicans SC5314Adenine phosphoribosyltransferase; flucytosine induced; repressed by nitric oxide; protein level decreased in stationary phase yeast cultures
orf19.1449Candida albicans SC5314Protein of unknown function; induced in azole-resistant strain that overexpresses MDR1; protein present in exponential and stationary growth phase yeast cultures; Spider biofilm induced
orf19.7331FCY24Candida albicans SC5314Putative transporter; more similar to S. cerevisiae Tpn1, which is a vitamin B6 transporter, than to purine-cytosine permeases; transcription is regulated by Nrg1; Spider biofilm induced
orf19.7332ELF1Candida albicans SC5314Putative mRNA export protein; Walker A and B (ATP/GTP binding) motifs; required for wild-type morphology, growth; expressed in hyphal, pseudohyphal, and yeast form; Hap43-induced; Spider and flow model biofilm induced
orf19.7335PRE8Candida albicans SC5314Putative alpha-2_sc subunit of proteasome; macrophage-induced protein; regulated by Gcn2p and Gcn4p; transcription is positively regulated by Tbf1p; stationary phase enriched protein
orf19.7339BGL22Candida albicans SC5314Putative glucanase; induced during cell wall regeneration
orf19.4791Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.4793Candida albicans SC5314Putative ribosome-associated protein; ortholog of S. cerevisiae Tma16; Hap43-induced gene; Spider biofilm induced
Locus IdGene NameOrganismDescription
orf19.1453SPT5Candida albicans SC5314Protein similar to S. cerevisiae Spt5p transcription elongation factor; transposon mutation affects filamentous growth
orf19.4799CEF1Candida albicans SC5314Putative mRNA splicing factor; ortholog is essential in S. cerevisiae; Spider biofilm induced
orf19.1457Candida albicans SC5314Putative RNA polymerase transcription factor TFIIH core component; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.1459PPE1Candida albicans SC5314Protein similar to S. cerevisiae Ppe1p; shows genetic interaction with some genes involved in diploid filamentous growth and haploid invasive growth in S. cerevisiae
orf19.301PGA18Candida albicans SC5314Putative GPI-anchored protein; regulated by Nrg1, Tup1; rat catheter biofilm repressed
orf19.304Candida albicans SC5314Putative transporter similar to MDR proteins; fungal-specific; Spider biofilm induced
orf19.6094VPS53Candida albicans SC5314Protein of unknown function
orf19.5439Candida albicans SC5314Protein of unknown function
orf19.2890Candida albicans SC5314Protein of unknown function
orf19.6099CCT8Candida albicans SC5314Chaperonin-containing T-complex subunit; role in hyphal morphogenesis, particularly starvation-induced; essential; expression in S. cerevisiae inhibits Ras2-mediated pathways; CCT8 and TRP1 overlap; Spider biofilm repressed
orf19.2891Candida albicans SC5314Protein of unknown function
orf19.2895VMA8Candida albicans SC5314Putative vacuolar H+-ATPase subunit; regulated by Nrg1 and Mig1; transcript increases in populations of cells exposed to fluconazole over multiple generations; rat catheter and Spider biofilm repressed
orf19.2897SOU2Candida albicans SC5314Protein similar to Sou1; not required for utilization of L-sorbose; Spider biofilm induced
orf19.2898Candida albicans SC5314Protein of unknown function
orf19.5440RPT2Candida albicans SC5314Putative ATPase of the 19S regulatory particle of the 26S proteasome; oxidative stress-induced via Cap1; Spider biofilm repressed
orf19.5442Candida albicans SC5314Protein of unknown function
orf19.5443BNA4Candida albicans SC5314Putative kynurenine 3-monooxygenase, involved in NAD biosynthesis; transposon mutation affects filamentous growth; Hap43p-repressed gene; oral infection upregulated; mutants have reduced capacity to damage oral epithelial cells
orf19.2102CKB1Candida albicans SC5314Regulatory subunit of protein kinase CK2 (casein kinase II), beta subunit; null mutants are hypersensitive to caspofungin and hydrogen peroxide medium
orf19.2104Candida albicans SC5314Protein of unknown function
orf19.2105Candida albicans SC5314Putative pre-mRNA-splicing factor; possibly an essential gene, disruptants not obtained by UAU1 method
Locus IdGene NameOrganismDescription
orf19.2106Candida albicans SC5314Putative protein of unknown function; Hap43p-repressed gene
orf19.2108SOD6Candida albicans SC5314Copper- and zinc-containing superoxide dismutase; gene family includes SOD1, SOD4, SOD5, and SOD6; gene may contain an intron; Hap43-repressed; flow model and rat catheter biofilm induced
orf19.2110Candida albicans SC5314Protein of unknown function
orf19.5454DAL1Candida albicans SC5314Putative allantoinase; transcript regulated by Nrg1 and Mig1; macrophage/pseudohyphal-repressed
orf19.5455Candida albicans SC5314Protein of unknown function
orf19.2113Candida albicans SC5314Putative integral peroxisomal membrane protein; Hap43p-repressed gene
orf19.2114Candida albicans SC5314Predicted uricase; ortholog of S. pombe SPCC1223.09; Spider biofilm induced
orf19.2116NAT2Candida albicans SC5314Putative N-terminal acetyltransferase; Hap43p-repressed gene; mutation confers hypersensitivity to toxic ergosterol analog
orf19.493RPL15ACandida albicans SC5314Putative ribosomal protein; repressed upon phagocytosis by murine macrophage; positively regulated by Tbf1; Spider biofilm repressed
orf19.6873RPS8ACandida albicans SC5314Small 40S ribosomal subunit protein; induced by ciclopirox olamine; repressed upon phagocytosis by murine macrophage; 5'-UTR intron; Hap43-induced; Spider biofilm repressed
orf19.6874Candida albicans SC5314Putative helix-loop-helix (HLH) transcription factor with a role in filamentous growth
orf19.3531Candida albicans SC5314Protein of unknown function
orf19.6875VPS35Candida albicans SC5314Putative role in vacuolar sorting; downregulated in biofilm; induced upon adherence to polystyrene
orf19.497EAF7Candida albicans SC5314Subunit of the NuA4 histone acetyltransferase complex
orf19.4190PAM18Candida albicans SC5314Predicted component of the presequence translocase-associated import motor (PAM complex) involved in protein import into mitochondrial matrix; rat catheter biofilm induced
orf19.3535Candida albicans SC5314Protein of unknown function
orf19.499Candida albicans SC5314Protein of unknown function
orf19.4193Candida albicans SC5314Protein of unknown function
orf19.3538FRE9Candida albicans SC5314Ferric reductase; alkaline induced; ciclopirox olamine; Hap43-induced
orf19.3539Candida albicans SC5314Predicted nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; Spider biofilm induced
Locus IdGene NameOrganismDescription
orf19.4196Candida albicans SC5314Dubious open reading frame
orf19.4197YHM2Candida albicans SC5314Predicted carrier protein; exports citrate from and imports oxoglutarate into the mitochondrion; alkaline induced; Spider biofilm repressed
orf19.6880COG4Candida albicans SC5314Protein of unknown function
orf19.6881YTH1Candida albicans SC5314Putative mRNA cleavage and polyadenylation specificity factor; transcription is regulated upon yeast-hyphal switch; decreased expression in hyphae compared to yeast-form cells; fluconazole or flucytosine induced
orf19.6883Candida albicans SC5314Putative oxysterol binding protein family; probable peripheral membrane protein of the Golgi complex; flow model and Spider biofilm repressed
orf19.6884GWT1Candida albicans SC5314Inositol acyltransferase with role in early steps of GPI anchor biosynthetic process; antifungal drug target
orf19.3542LEM3Candida albicans SC5314Putative membrane protein; mutation increases resistance to miltefosine; early-stage flow model biofilm induced
orf19.3543Candida albicans SC5314Dubious open reading frame
orf19.439Candida albicans SC5314Protein of unknown function
orf19.4213Candida albicans SC5314Putative iron transport multicopper oxidase precursor; flucytosine induced; caspofungin repressed
orf19.7558YTA6Candida albicans SC5314Protein similar to S. cerevisiae Yta6p ATPase but ortholog of S. cervisiae Sap1; transposon mutation affects filamentous growth; induced by Mnl1 under weak acid stress
orf19.4216Candida albicans SC5314Putative heat shock protein; decreased expression in hyphae; transcription is increased in populations of cells exposed to fluconazole over multiple generations; overexpression increases resistance to farnesol and azoles
orf19.1672Candida albicans SC5314Alpha subunit of COPI vesicle coatomer complex; role in ER to Golgi vesicle-mediated transport, retrograde vesicle-mediated transport, Golgi to ER transport; flow model biofilm repressed
orf19.1675Candida albicans SC5314Protein of unknown function
orf19.1677Candida albicans SC5314Protein of unknown function; transcript detected on high-resolution tiling arrays
orf19.1679Candida albicans SC5314Protein of unknown function
orf19.6901Candida albicans SC5314Protein of unknown function
orf19.6903Candida albicans SC5314Predicted RNA polymerase III subunit C37; Spider biofilm induced
orf19.7561DEF1Candida albicans SC5314RNA polymerase II regulator; role in filamentation, epithelial cell escape, dissemination in RHE model; induced by fluconazole, high cell density; Efg1/hyphal regulated; role in adhesion, hyphal growth on solid media; Spider biofilm induced
orf19.6906ASC1Candida albicans SC531440S ribosomal subunit similar to G-beta subunits; glucose or N starvation induced filamentation; required for virulence in mice; snoRNA snR24 encoded in ASC1 intron; repressed in stationary phase; GlcNAc-induced; Spider biofilm repressed
Locus IdGene NameOrganismDescription
orf19.6907Candida albicans SC5314Protein of unknown function
orf19.528SEC26Candida albicans SC5314Secretory vesicles coatomer complex protein
orf19.2310.1RPL29Candida albicans SC5314Ribosomal protein L29; induced upon germ tube formation; colony morphology-related gene regulation by Ssn6; intron in 5'-UTR; Spider biofilm repressed
orf19.827.1RPL39Candida albicans SC5314Ribosomal protein L39; transcript induced upon germ tube formation; colony morphology-related gene regulation by Ssn6; Hap43-induced
orf19.7188RPP1BCandida albicans SC5314Conserved acidic ribosomal protein, likely involved in regulation of translation elongation; interacts with Rpp2A; 1 of 4 similar C. albicans ribosomal proteins (Rpp1A, Rpp1B, Rpp2A, Rpp2B); induced by Tbf1; Spider biofilm repressed
orf19.6403.1RPP2ACandida albicans SC5314Acidic ribosomal protein; likely role in translation elongation regulation; interacts with Rpp1B; 1 of 4 similar ribosomal proteins (Rpp1A, Rpp1B, Rpp2A, Rpp2B); CUG start codon; upstream uORFs; Tbf1-induced; Spider biofilm repressed
orf19.2770.1SOD1Candida albicans SC5314Cytosolic copper- and zinc-containing superoxide dismutase; role in protection from oxidative stress; required for full virulence; alkaline induced by Rim101; induced by human blood; rat catheter, flow model and Spider biofilm repressed
orf19.7340Candida albicans SC5314Protein of unknown function; possibly C. albicans specific; Spider biofilm induced
orf19.7341Candida albicans SC5314Protein of unknown function; flow model biofilm induced; ketoconazole-repressed
orf19.306USO5Candida albicans SC5314Putative type II myosin heavy chain; transcription is induced upon filamentous growth and in response to alpha pheromone in SpiderM medium
orf19.7342AXL1Candida albicans SC5314Putative endoprotease; induced by alpha factor; transcript is upregulated in an RHE model of oral candidiasis and in clinical isolates from HIV+ patients with oral candidiasis
orf19.7343Candida albicans SC5314Protein of unknown function
orf19.4000GRF10Candida albicans SC5314Putative homeodomain transcription factor; null mutant is an adenine auxotroph; Spider biofilm induced; promoter bound by Bcr1, Tec1, Efg1, Ndt80 and Brg1
orf19.7344Candida albicans SC5314Protein of unknown function
orf19.4001Candida albicans SC5314Protein of unknown function
orf19.7345Candida albicans SC5314Protein of unknown function
orf19.7347Candida albicans SC5314Protein of unknown function
orf19.7348Candida albicans SC5314Protein of unknown function
orf19.4006Candida albicans SC5314Protein of unknown function
orf19.4009CNB1Candida albicans SC5314Regulatory subunit of calcineurin B (Ca[2+]-calmodulin-regulated S/T protein phosphatase); required for wild-type resistance to fluconazole or to SDS; micafungin is fungicidal to null mutant
Locus IdGene NameOrganismDescription
orf19.1461Candida albicans SC5314S. pombe ortholog SPCC576.01c is a predicted sulfonate dioxygenase; possibly transcriptionally regulated upon hyphal formation; Spider biofilm induced
orf19.1462SMP2Candida albicans SC5314Putative Mg2+-dependent phosphatidate phosphatase; transcript regulated by Nrg1
orf19.1465Candida albicans SC5314Protein of unknown function
orf19.1467COX13Candida albicans SC5314Cytochrome c oxidase; flucytosine induced; repressed by nitric oxide
orf19.1468CDC55Candida albicans SC5314Protein of unknown function
orf19.310Candida albicans SC5314Putative mitochondrial protein with a predicted role in cell wall biogenesis; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.313DAL4Candida albicans SC5314Putative allantoin permease; fungal-specific (no human or murine homolog)
orf19.314Candida albicans SC5314Protein of unknown function
orf19.316SEC13Candida albicans SC5314Putative protein transport factor; antigenic during murine systemic infection; macrophage-downregulated protein; protein level decreases in stationary phase cultures; Spider biofilm repressed
orf19.2119NDT80Candida albicans SC5314Ortholog of Ndt80; meiosis-specific transcription factor; activator of CDR1 induction by antifungal drugs; required for wild-type drug resistance and for Spider biofilm formation; transcript induced by antifungal drug treatment
orf19.4801Candida albicans SC5314Protein of unknown function
orf19.4804LIP2Candida albicans SC5314Secreted lipase; member of a differentially expressed lipase gene family; expressed in alimentary tract, but not oral tissue, during mouse oral infection; may have a role in nutrition and/or in creating an acidic microenvironment
orf19.5463SEC6Candida albicans SC5314Predicted subunit of the exocyst complex, involved in exocytosis; localizes to a crescent on the surface of the hyphal tip; Hap43p-repressed gene, overlaps orf19.5464 and orf19.5465
orf19.4807Candida albicans SC5314Protein of unknown function
orf19.4808NUP188Candida albicans SC5314Putative nuclear pore complex subunit; transcript regulated by Nrg1 and Mig1
orf19.5465Candida albicans SC5314Protein of unknown function
orf19.5466RPS24Candida albicans SC5314Predicted ribosomal protein; hyphal downregulated; repressed upon phagocytosis by murine macrophage; transcriptionally activated by Tbf1; Spider biofilm repressed
orf19.5467TLO7Candida albicans SC5314Member of a family of telomere-proximal genes of unknown function; may be spliced in vivo; rat catheter biofilm repressed
orf19.2124Candida albicans SC5314Predicted alcohol dehydrogenase; Spider biofilm induced
orf19.2125Candida albicans SC5314Protein of unknown function; GlcNAc-induced protein; Spider biofilm induced; rat catheter biofilm repressed
Locus IdGene NameOrganismDescription
orf19.2128Candida albicans SC5314Protein of unknown function
orf19.4811Candida albicans SC5314Putative tricarboxylate carrier family protein; localized to the mitochondrial membrane
orf19.4813GUA1Candida albicans SC5314Putative GMP synthase, involved in the final step of guanine biosynthesis; soluble protein in hyphae; flucytosine induced; macrophage-downregulated protein abundance; protein level decreases in stationary phase cultures
orf19.4814Candida albicans SC5314Protein of unknown function
orf19.4816Candida albicans SC5314Protein of unknown function; induced by nitric oxide
orf19.4818Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.2132Candida albicans SC5314Protein of unknown function
orf19.2133LIP4Candida albicans SC5314Secreted lipase, member of a differentially expressed lipase gene family with possible roles in nutrition and/or in creating an acidic microenvironment; expressed more strongly during mucosal infections than during systemic infections
orf19.2135TSM1Candida albicans SC5314Putative transcription initiation factor TFIID subunit; transcript is upregulated in clinical isolates from HIV+ patients with oral candidiasis; Nrg1-regulated
orf19.3546PEX2Candida albicans SC5314Protein of unknown function
orf19.3548Candida albicans SC5314Protein of unknown function
orf19.6891RFC1Candida albicans SC5314Putative DNA replication factor C subunit; ortholog of S. cerviaie Rfc1; likely essential, based on an insertional mutagenesis strategy; rat catheter biofilm repressed
orf19.3550SGO1Candida albicans SC5314Component of the spindle checkpoint; cell-cycle regulated periodic mRNA expression
orf19.3551DAD2Candida albicans SC5314Essential subunit of the Dam1 (DASH) complex, which acts in chromosome segregation by coupling kinetochores to spindle microtubules
orf19.3552Candida albicans SC5314Protein of unknown function
orf19.6896Candida albicans SC5314Predicted ORF overlapping the Major Repeat Sequence on chromosome 7; member of a family encoded by FGR6-related genes in the RB2 repeat sequence
orf19.6897Candida albicans SC5314Protein of unknown function
orf19.3554AAT1Candida albicans SC5314Aspartate aminotransferase; soluble protein in hyphae; macrophage-induced protein; alkaline upregulated; amphotericin B repressed; gene used for strain identification by multilocus sequence typing; farnesol-, Hap43p-induced; GlcNAc-induced
orf19.3555BUD14Candida albicans SC5314Putative SH3-domain-containing protein; predicted role in bud-site selection; Spider biofilm induced
orf19.6899Candida albicans SC5314Putative oxidoreductase; mutation confers hypersensitivity to toxic ergosterol analog; rat catheter and Spider biofilm induced
Locus IdGene NameOrganismDescription
orf19.3557GPI19Candida albicans SC5314Subunit of GPI-GlcNAc transferase; role in synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in GPI anchor synthesis; complements S. cerevisiae gpi19 mutant; flow model biofilm induced
orf19.3558Candida albicans SC5314Protein of unknown function
orf19.3559Candida albicans SC5314S. cerevisiae ortholog Mrps35p is a structural constituent of ribosome and localizes to mitochondrial small ribosomal subunit; the snoRNA CD39 is encoded within the MRPS35 intron
orf19.6100Candida albicans SC5314Cardiolipin synthase; ortholog of S. cerevisiae Crd1; transcript is upregulated in clinical isolates from HIV+ patients with oral candidiasis; mutants are viable; Spider biofilm repressed
orf19.6102RCA1Candida albicans SC5314Protein involved in regulation of carbonic anhydrases; controls CO2 sensing; bZIP domain-containing transcription factor of the ATF/CREB family; null mutant displays slow growth, abnormal colony morphology and invasive growth
orf19.6103Candida albicans SC5314Protein of unknown function
orf19.6109TUP1Candida albicans SC5314Transcriptional corepressor; represses filamentous growth; regulates switching; role in germ tube induction, farnesol response; in repression pathways with Nrg1, Rfg1; farnesol upregulated in biofilm; rat catheter, Spider biofilm repressed
orf19.2901NUP60Candida albicans SC5314Ortholog of S. cerevisiae Nup60p; a subunit of the nuclear pore complex; mutants are viable
orf19.2905Candida albicans SC5314Protein of unknown function
orf19.3300ZPR1Candida albicans SC5314Protein with putative zinc finger; regulated by Gcn4p; repressed in response to amino acid starvation (3-aminotriazole treatment); upregulation correlates with clinical development of fluconazole resistance
orf19.6644Candida albicans SC5314Protein of unknown function; 2 predicted transmembrane domains; transcript detected on high-resolution tiling arrays; flow model biofilm induced; Spider biofilm repressed
orf19.265Candida albicans SC5314Protein with a ribonuclease III domain; flow model biofilm induced; Spider biofilm induced
orf19.3301Candida albicans SC5314Putative ubiquitin ligase complex component; induced by heavy metal (cadmium) stress; Hog1-induced; transcript induced by Mnl1p under weak acid stress; flow model biofilm induced; Spider biofilm induced
orf19.6645HMO1Candida albicans SC5314HMG-box transcription factor; binds upstream of hexose and ergosterol metabolism and cell cycle genes; activates pseudohyphal growth when expressed in S. cerevisiae; repressed in hyphae; Spider biofilm repressed
orf19.267Candida albicans SC5314Protein required for normal filamentous growth; mRNA binds She3
orf19.268Candida albicans SC5314Protein of unknown function
orf19.3304Candida albicans SC5314Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in the nucleus and cytoplasm; Spider biofilm induced
orf19.3305ZCF17Candida albicans SC5314Putative Zn(II)2Cys6 transcription factor
orf19.269SES1Candida albicans SC5314Seryl-tRNA synthetase; charges the tRNA that recognizes the CUG codon, which typically specifies Leu, but specifies Ser in C. albicans; complements S. cerevisiae ses1 mutant viability; soluble protein in hyphae; macrophage-regulated
orf19.3306Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.6650Candida albicans SC5314Protein of unknown function
orf19.272FAA21Candida albicans SC5314Predicted acyl CoA synthetase; upregulated upon phagocytosis; transcript regulated by Nrg1 and Mig1
orf19.6652DBP8Candida albicans SC5314Protein similar to S. cerevisiae Dbp8p, an ATP-dependent helicase involved in rRNA processing; oxidative stress-repressed via Cap1p; flucytosine repressed; likely to be essential for growth, based on insertional mutagenesis
orf19.273Candida albicans SC5314Protein of unknown function
orf19.6653MTG2Candida albicans SC5314Putative Obg family GTPase member; peripheral protein of the mitochondrial inner membrane; associates with the large ribosomal subunit; required for mitochondrial translation; rat catheter biofilm repressed
orf19.6654Candida albicans SC5314Predicted membrane transporter, member of the L-amino acid transporter-3 (LAT3) family, major facilitator superfamily (MFS)
orf19.6656Candida albicans SC5314Spermidine transporter; induced in strains from HIV patients with oral candidiasis; alkaline repressed; amphotericin B induced; colony morphology regulated by Ssn6; reduced oral epithelial cell damage by mutant; Spider biofilm induced
orf19.277THI6Candida albicans SC5314Putative thiamin-phosphate pyrophosphorylase, hydroxyethylthiazole kinase; fungal-specific; Spider biofilm induced
orf19.278Candida albicans SC5314Protein of unknown function; required for adhesion to abiotic substrate; Spider biofilm induced
orf19.6659GAP6Candida albicans SC5314Broad-specificity amino acid permease; Plc1, Gcn4 regulated; rat catheter biofilm induced
orf19.279Candida albicans SC5314Protein with a predicted D-Tyr-tRNA(Tyr) deacylase domain; Hap43-repressed gene
orf19.3318Candida albicans SC5314Protein of unknown function
orf19.317PNP1Candida albicans SC5314Purine nucleoside phosphorylase; metabolizes inosine and guanosine nucleosides; in the nicotinamide riboside salvage pathway; Spider biofilm repressed
orf19.7353Candida albicans SC5314Protein of unknown function
orf19.318Candida albicans SC5314Protein of unknown function
orf19.4010PAN3Candida albicans SC5314Protein of unknown function
orf19.319Candida albicans SC5314Protein of unknown function
orf19.7355SSN8Candida albicans SC5314Ortholog of S. cerevisiae Ssn8; a component of RNA polymerase II holoenzyme; mutants are viable and are sensitive to hydrogen peroxide medium
orf19.4012PCL5Candida albicans SC5314Putative cyclin for Pho85 kinase; Gcn4-induced; suppresses toxicity of C. albicans Gcn4 overproduction in S. cerevisiae via increased Pho85-dependent phosphorylation and degradation of Gcn4; rat catheter and Spider biofilm induced
orf19.7356Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.7357Candida albicans SC5314Protein of unknown function
orf19.4014Candida albicans SC5314Planktonic growth-induced gene
orf19.4015CAG1Candida albicans SC5314heterotrimeric G protein alpha subunit; positive role in mating pheromone response; opaque-enriched transcript; transcript repressed by MTLa1-MTLalpha2; regulated by hemoglobin-responsive Hbr1 via MTL genes; rat catheter biofilm repressed
orf19.4017Candida albicans SC5314Protein of unknown function
orf19.4019Candida albicans SC5314Protein of unknown function
orf19.1470RPS26ACandida albicans SC5314Ribosomal protein; regulated by Nrg1, Tup1; repressed upon phagocytosis by murine macrophage; alternatively spliced intron in 5'-UTR; Spider biofilm repressed
orf19.1473Candida albicans SC53142-hydroxyacid dehydrogenase domain-containing protein; Hap43-repressed gene; induced by alpha pheromone in SpiderM medium
orf19.1476Candida albicans SC5314Protein of unknown function
orf19.1478STT3Candida albicans SC5314Putative oligosaccharyltransferase complex component; flow model and rat catheter biofilm repressed
orf19.1479Candida albicans SC5314Ortholog of the mitochondria localized S. cerevisiae Pib2 protein of unknown function; has a FYVE zinc finger domain; Spider biofilm induced
orf19.321Candida albicans SC5314Protein of unknown function
orf19.322Candida albicans SC5314Protein of unknown function
orf19.6702DED81Candida albicans SC5314Putative tRNA-Asn synthetase; genes encoding ribosomal subunits, translation factors, tRNA synthetases are downregulated upon phagocytosis by murine macrophage; protein enriched in stationary phase yeast cultures
orf19.6703Candida albicans SC5314Protein of unknown function
orf19.325Candida albicans SC5314Putative mRNA cleavage and polyadenlylation factor; heterozygous null mutant exhibits hypersensitivity to parnafungin and cordycepin in the C. albicans fitness test
orf19.2137Candida albicans SC5314Protein of unknown function
orf19.4820Candida albicans SC5314Protein of unknown function
orf19.4822LIP10Candida albicans SC5314Secreted lipase, member of a lipase gene family whose members are expressed differentially in response to carbon source and during infection; may have a role in nutrition and/or in creating an acidic microenvironment
orf19.5480ILV1Candida albicans SC5314Putative threonine dehydratase; regulated by Gcn4 and Gcn2; induced by amino acid starvation (3-AT); protein present in yeast exponential and stationary phase cultures; early-stage flow model biofilm induced
orf19.4826IDH1Candida albicans SC5314Putative mitochondrial NAD-isocitrate dehydrogenase subunit 1; soluble protein in hyphae; protein level decrease in stationary phase cultures
Locus IdGene NameOrganismDescription
orf19.4827ADE12Candida albicans SC5314Adenylosuccinate synthase; upregulated in biofilm; decreased expression in hyphae vs yeast-form cells; not induced during GCN response, in contrast to S. cerevisiae ADE12, which is induced by Gcn4p; stationary phase-enriched protein
orf19.5484SER1Candida albicans SC5314Putative 3-phosphoserine aminotransferase; predicted role in serine and glycine biosynthesis; protein present in exponential and stationary yeast growth phases; Spider biofilm repressed
orf19.5486Candida albicans SC5314Putative endoribonuclease; heterozygous null mutant exhibits hypersensitivity to parnafungin and cordycepin in the C. albicans fitness test
orf19.5487CDC46Candida albicans SC5314Putative hexameric MCM complex subunit; predicted role in control of cell division; periodic mRNA expression. peak at cell-cycle M/G1 phase; regulated by tyrosol, cell density, Plc1; repressed by alpha pheromone in SpiderM medium
orf19.5488Candida albicans SC5314Protein of unknown function
orf19.2146HAT2Candida albicans SC5314Putative Hat1-Hat2 histone acetyltransferase complex subunit; role in DNA damage repair and morphogenesis; mutations cause constitutive pseudohyphal growth, caspofungin sensitivity; rat catheter and Spider biofilm repressed
orf19.4830Candida albicans SC5314Protein of unknown function
orf19.4831MTS1Candida albicans SC5314Sphingolipid C9-methyltransferase; catalyzes methylation of the 9th carbon in the long chain base component of glucosylceramides; glucosylceramide biosynthesis is important for virulence; Spider biofilm repressed
orf19.5490Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; merged with orf19.5489 in Assembly 21
orf19.4835Candida albicans SC5314Protein of unknown function
orf19.4836URA1Candida albicans SC5314Dihydroorotate dehydrogenase; de novo pyrimidine biosynthesis; regulated by yeast-hypha switch, Nrg1/Mig1/Tup1; flow model biofilm induced; rat catheter and Spider biofilm repressed
orf19.2150Candida albicans SC5314Putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-alpha; Spider biofilm repressed
orf19.2151NAG6Candida albicans SC5314Protein required for wild-type mouse virulence and wild-type cycloheximide resistance; putative GTP-binding motif; similar to S. cerevisiae Yor165Wp; in gene cluster that encodes enzymes of GlcNAc catabolism; no human or murine homolog
orf19.2154HXK1Candida albicans SC5314N-acetylglucosamine (GlcNAc) kinase; involved in GlcNAc utilization; required for wild-type hyphal growth and mouse virulence; GlcNAc-induced transcript; induced by alpha pheromone in SpiderM medium
orf19.3561CDC7Candida albicans SC5314Putative kinase; cell-cycle regulated periodic mRNA expression; S. cerevisiae ortholog is not cell-cycle regulated; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.2907PGA42Candida albicans SC5314Putative GPI-anchored adhesin-like protein; decreased transcription is observed in azole-resistant strains that overexpress CDR1 and CDR2 or MDR1
orf19.2908Candida albicans SC5314Predicted oxidoreductase; rat catheter biofilm induced
orf19.3564RPC40Candida albicans SC5314Putative RNA polymerase; protein level decreases in stationary phase cultures; Hap43p-induced gene
orf19.3565Candida albicans SC5314Protein of unknown function
orf19.3568RXT3Candida albicans SC5314Putative transcriptional repressor
Locus IdGene NameOrganismDescription
orf19.6112CTA2Candida albicans SC5314Putative transcription factor; Med2 mediator domain; activates transcription in 1-hybrid assay in S. cerevisiae; repressed by Efg1; member of a family of telomere-proximal genes; Tbf1-induced
orf19.6114Candida albicans SC5314Protein of unknown function; transcript detected on high-resolution tiling arrays
orf19.6116GLK4Candida albicans SC5314Putative glucokinase; decreased expression in hyphae compared to yeast-form cells
orf19.6117Candida albicans SC5314S. pombe ortholog SPAC5D6.04 is a predicted auxin family transmembrane transporter; ketoconazole and hypoxia induced
orf19.2910PGA43Candida albicans SC5314Putative GPI-anchored protein
orf19.6119Candida albicans SC5314Protein of unknown function; Spider biofilm repressed
orf19.2915Candida albicans SC5314Protein of unknown function
orf19.3571Candida albicans SC5314Protein of unknown function
orf19.3572Candida albicans SC5314Protein of unknown function
orf19.3573PEX6Candida albicans SC5314Protein of unknown function
orf19.2919MPH1Candida albicans SC5314Protein similar to S. cerevisiae Mph1p, which is a DNA helicase involved in DNA repair; induced under hydroxyurea treatment
orf19.3575CDC19Candida albicans SC5314Pyruvate kinase at yeast cell surface; Gcn4/Hog1/GlcNAc regulated; Hap43/polystyrene adherence induced; repressed by phagocytosis/farnesol; hyphal growth role; stationary phase enriched; flow model biofilm induced; Spider biofilm repressed
orf19.6121MNL1Candida albicans SC5314Transcription factor; induces transcripts of stress response genes via SLE (STRE-like) elements; required for adaptation to weak acid stress; activates a subset of the genes that are repressed by Nrg1
orf19.6124ACE2Candida albicans SC5314Transcription factor; similar to S. cerevisiae Ace2 and Swi5; regulates morphogenesis, cell separation, adherence, virulence in a mice; mutant is hyperfilamentous; rat catheter and Spider biofilm induced
orf19.6127LPD1Candida albicans SC5314Putative dihydrolipoamide dehydrogenase; soluble in hyphae; antigenic in human oral infection and murine systemic infection; macrophage-induced protein; protein present in exponential and stationary phase yeast cultures; Hap43p-repressed
orf19.280Candida albicans SC5314Protein of unknown function
orf19.6660Candida albicans SC5314Protein of unknown function; mRNA binds to She3; Hap43-repressed; rat catheter and flow model biofilm induced
orf19.6662Candida albicans SC5314Putative coenzyme Q (ubiquinone) binding protein; transcript is upregulated in clinical isolates from HIV+ patients with oral candidiasis
orf19.6663RPS25BCandida albicans SC5314Ribosomal protein; macrophage/pseudohyphal-induced after 16 h; repressed upon phagocytosis by murine macrophage; transcript positively regulated by Tbf1; 5'-UTR intron; Hap43-induced; Spider biofilm repressed
orf19.3320Candida albicans SC5314Dubious open reading frame
Locus IdGene NameOrganismDescription
orf19.285Candida albicans SC5314Ortholog of S. cerevisiae Igo2; role in mRNA stabilization of mRNA; Spider biofilm induced
orf19.6665Candida albicans SC5314Protein of unknown function
orf19.6667Candida albicans SC5314Predicted histone deacetylase activity; Spider biofilm induced
orf19.3324TIFCandida albicans SC5314Translation initiation factor; upregulated in highly virulent strain compared to less virulent strain; antigenic in human; flucytosine induced; downregulated upon phagocytosis by macrophages; Spider biofilm repressed
orf19.6668Candida albicans SC5314Protein of unknown function
orf19.3325Candida albicans SC5314Putative glycogen synthesis initiator; regulated by Efg1 and Efh1; Hog1-repressed; colony morphology-related gene regulation by Ssn6; induced by prostaglandins; flow model biofilm induced
orf19.290KRE5Candida albicans SC5314UDP-glucose:glycoprotein glucosyltransferase; 1,6-beta-D-glucan biosynthesis, hyphal growth, virulence in mouse IV model; partially complements S. cerevisiae kre5 mutant defects; flow biofilm repressed, Bcr1-repressed in RPMI a/a biofilms
orf19.6670CAC2Candida albicans SC5314Component of the chromatin assembly factor I (CAF-1); involved in regulation of white-opaque switching frequency; macrophage-induced
orf19.6671LAP4Candida albicans SC5314Protein similar to aminopeptidase I; mutation confers hypersensitivity to amphotericin B; transcript regulated in macrophage response; flow model biofilm induced
orf19.292Candida albicans SC5314Protein of unknown function
orf19.6672MDJ1Candida albicans SC5314Putative member of the HSP40 (DnaJ) family of chaperones; rat catheter and Spider biofilm induced
orf19.3330CRL1Candida albicans SC5314Predicted GTPase of RHO family; CAAX motif geranylgeranylated; expression in S. cerevisiae causes dominant-negative inhibition of pheromone response
orf19.6674BTS1Candida albicans SC5314Putative geranylgeranyl diphosphate synthase; repressed by benomyl treatment; Spider biofilm induced
orf19.295Candida albicans SC5314Protein of unknown function
orf19.3332Candida albicans SC5314Ortholog of Bre4 in S. cerevisiae has a role in brefeldin A resistence; a drug that affect intracellular transport; Spider biofilm induced
orf19.6676Candida albicans SC5314Protein of unknown function
orf19.296Candida albicans SC5314Protein of unknown function
orf19.7361Candida albicans SC5314Protein of unknown function
orf19.6706GYP7Candida albicans SC5314Protein similar to S. cerevisiae Gyp7p (GTPase-activating protein for Ypt1p); caspofungin-induced
orf19.7363KRE6Candida albicans SC5314Essential beta-1,6-glucan synthase subunit; change in mRNA length, not abundance, at yeast-hypha transition; alkaline induced by Rim101, on cell wall regeneration; Spider biofilm induced; Bcr1-repressed in RPMI a/a biofilms
Locus IdGene NameOrganismDescription
orf19.7364Candida albicans SC5314Protein of unknown function
orf19.4021Candida albicans SC5314Protein of unknown function
orf19.7365Candida albicans SC5314Protein of unknown function
orf19.4022SDH4Candida albicans SC5314Succinate dehydrogenase, membrane subunit; induced in high iron
orf19.7366Candida albicans SC5314Protein of unknown function
orf19.7367UBP1Candida albicans SC5314Protein of unknown function
orf19.4024RIB5Candida albicans SC5314Putative riboflavin synthase; fungal-specific (no human or murine homolog); farnesol-downregulated; protein present in exponential and stationary growth phase yeast cultures
orf19.7368Candida albicans SC5314Protein of unknown function
orf19.7369TRM12Candida albicans SC5314Protein of unknown function
orf19.4028Candida albicans SC5314Putative cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting; flow model biofilm induced
orf19.4029Candida albicans SC5314Protein of unknown function
orf19.1483Candida albicans SC5314Protein of unknown function
orf19.1484Candida albicans SC5314Ortholog of S, cerevisiae Spc24; a component of the conserved kinetochore-associated Ndc80 complex involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering; Hap43-induced gene
orf19.1486Candida albicans SC5314Protein with a life-span regulatory factor domain; regulated by Sef1, Sfu1, and Hap43; flow model biofilm induced; Spider biofilm induced
orf19.6710UTP9Candida albicans SC5314Small-subunit processome protein; Ssr1-induced; repressed by prostaglandins; physically interacts with TAP-tagged Nop1
orf19.331Candida albicans SC5314Protein of unknown function
orf19.332Candida albicans SC5314Member of a complex that contains Prp19; stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; Spider biofilm induced
orf19.6712Candida albicans SC5314Protein of unknown function
orf19.5498EFH1Candida albicans SC5314APSES transcription factor; homodimer; minor role in transcriptional regulation vs Efg1; regulates filamentous growth, phenotypic switch; EFG1 and EFH1 genetically interact; expression interferes with mouse intestinal tract colonization
orf19.2156NAG1Candida albicans SC5314Glucosamine-6-phosphate deaminase; required for normal hyphal growth and mouse virulence; converts glucosamine 6-P to fructose 6-P; reversible reaction in vitro; gene and protein is GlcNAc-induced; Spider biofilm induced
Locus IdGene NameOrganismDescription
orf19.4841SHY1Candida albicans SC5314Cytochrome c oxidase biosynthesis protein; transcript regulated by Nrg1 and Mig1
orf19.4842Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.4843Candida albicans SC5314Putative iron/copper reductas; involved in iron homeostasis; rat catheter and Spider biofilm induced
orf19.1500Candida albicans SC5314Protein of unknown function
orf19.4844Candida albicans SC5314Protein of unknown function
orf19.4845TVP18Candida albicans SC5314Putative integral membrane protein; fluconazole-induced
orf19.1502Candida albicans SC5314Protein of unknown function
orf19.4846Candida albicans SC5314GlcNAc-induced protein
orf19.2160NAG4Candida albicans SC5314Putative transporter; fungal-specific; similar to Nag3p and to S. cerevisiae Ypr156Cp and Ygr138Cp; required for wild-type mouse virulence and wild-type cycloheximide resistance; gene cluster encodes enzymes of GlcNAc catabolism
orf19.1505Candida albicans SC5314Protein of unknown function
orf19.4849Candida albicans SC5314Protein required for localizing proteasomes to the nucleus; involved in ubiquitin-mediated protein degradation; possibly an essential gene, disruptants not obtained by UAU1 method; Spider biofilm induced
orf19.2163Candida albicans SC5314Protein of unknown function
orf19.1509ROD1Candida albicans SC5314Protein similar to S. cerevisiae Rod1;a membrane protein with a role in drug tolerance; repressed by Rgt1; mutant is viable
orf19.2166VMA5Candida albicans SC5314Putative vacuolar H(+)-ATPase; plasma membrane localized; rat catheter biofilm repressed
orf19.2168Candida albicans SC5314Putative sterol deacetylase; flow model biofilm induced; rat catheter biofilm repressed
orf19.4850Candida albicans SC5314Protein of unknown function
orf19.4853HCM1Candida albicans SC5314Protein with forkhead domain; similar to S. cerevisiae Hcm1p; Hap43p-induced gene
orf19.1510SRD1Candida albicans SC5314Sur7 family protein with PalI-like domains; not required for stress responses; mutant is viable
orf19.4856LIP3Candida albicans SC5314Secreted lipase; gene family member whose members are expressed differentially in response to carbon source and infection; possible role in nutrition and/or in creating an acidic microenvironment; flow model biofilm induced
orf19.4857Candida albicans SC5314Protein with a dual-specificity phosphatase domain; Hap43-induced gene
Locus IdGene NameOrganismDescription
orf19.4858VPS41Candida albicans SC5314Protein similar to S. cerevisiae Vps41p, which is involved in vacuole organization and biogenesis; transposon mutation affects filamentous growth; regulated by Gcn4p; induced in response to amino acid starvation (3-aminotriazole treatment)
orf19.6129MRPL8Candida albicans SC5314Mitochondrial 60S ribosomal protein subunit; Hap43p-repressed gene
orf19.2921Candida albicans SC5314Protein of unknown function
orf19.3582Candida albicans SC5314Protein of unknown function
orf19.3583Candida albicans SC5314Protein of unknown function
orf19.2928Candida albicans SC5314Protein of unknown function
orf19.3586Candida albicans SC5314Protein of unknown function
orf19.6131KSR1Candida albicans SC53143-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis
orf19.6133PIF1Candida albicans SC5314Putative DNA helicase; decreased transcription is observed upon fluphenazine treatment
orf19.6134Candida albicans SC5314Protein of unknown function
orf19.6135Candida albicans SC5314Protein of unknown function
orf19.6137Candida albicans SC5314Protein of unknown function
orf19.6138Candida albicans SC5314Protein similar to ferric reductase Fre10p; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.2930Candida albicans SC5314Predicted translation initiation factor; role in translational initiation; Spider biofilm repressed
orf19.6139FRE7Candida albicans SC5314Copper-regulated cupric reductase; repressed by ciclopirox olamine or 17-beta-estradiol; induced by alkaline conditions or interaction with macrophage; Spider biofilm induced
orf19.2933Candida albicans SC5314Protein of unknown function
orf19.2934Candida albicans SC5314Similar to S. cerevisiae Bud20; predicted role in cellular bud site selection; rat catheter and Spider biofilm induced
orf19.3590IPP1Candida albicans SC5314Putative inorganic pyrophosphatase; antigenic; soluble protein in hyphae; macrophage-induced protein; protein present in exponential and stationary phase yeast; possibly essential (UAU1 method); sumoylation target; Spider biofilm repressed
orf19.2935RPL10Candida albicans SC5314Ribosomal protein L10; intron in 5'-UTR; downregulated upon phagocytosis by murine macrophage; transcription regulated by yeast-hypha switch; Spider biofilm repressed
orf19.3592JEM1Candida albicans SC5314Functional homolog of S. cerevisiae Jem1p, which acts with Scj1p and Kar2p (BiP) in protein folding and ER-associated degradation of misfolded proteins, and also has a role in karyogamy; has J domain and 4 tetratricopeptide repeats
Locus IdGene NameOrganismDescription
CR_03070W_ADOM34Candida albicans SC5314Endonuclease involved in regulation of translation; stimulates translation of protein O-mannosyltransferase family which includes PMT1, PMT2, PMT4, PMT5, and PMT6; peloto ortholog; Hap43-repressed gene
orf19.3333Candida albicans SC5314Protein of unknown function
orf19.3334RPS21Candida albicans SC5314Protein component of the small (40S) subunit; repressed upon phagocytosis by murine macrophage; positively regulated by Tbf1; Spider biofilm repressed
orf19.6678Candida albicans SC5314Protein of unknown function; Hap43-repressed gene
orf19.6679Candida albicans SC5314Protein of unknown function
orf19.299ECM14Candida albicans SC5314Protein of unknown function
orf19.3338Candida albicans SC5314Protein of unknown function; Bcr1-repressed in RPMI a/a biofilms; rat catheter and Spider biofilm induced; ORF deleted and merged with orf19.3337
orf19.6680FGR27Candida albicans SC5314Zn(II)2Cys6 transcription factor; transposon mutation affects filamentous growth; required for yeast cell adherence to silicone substrate; Spider biofilm induced
orf19.6681Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.6684PNC1Candida albicans SC5314Putative nicotinamidase, involved in NAD salvage pathway; decreased transcription is observed in an azole-resistant strain that overexpresses MDR1
orf19.3341Candida albicans SC5314Putative tRNA-Arg synthetase; essential; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage; downregulated by growth in the mouse cecum
orf19.3342Candida albicans SC5314Protein of unknown function
orf19.6687Candida albicans SC5314Protein of unknown function; rat catheter biofilm repressed
orf19.3344VPS17Candida albicans SC5314Protein of unknown function
orf19.3345SIZ1Candida albicans SC5314Possible SUMO/Smt3 ligase; Rim101-repressed
orf19.3347RPB7Candida albicans SC5314Functional homolog of S. cerevisiae Rpb7; essential subunit of RNA Polymerase II; enhances hyperfilamentation of an S. cerevisiae rpb4 mutant; suppresses defects of S. cerevisiae rpb4 and ess1 mutants; Spider biofilm repressed
orf19.3349Candida albicans SC5314Putative RNA polymerase II subunit B150; heterozygous null mutant exhibits resistance to parnafungin in the C. albicans fitness test
orf19.6692MNN26Candida albicans SC5314Putative alpha-1,2-mannosyltransferase; mutant sensitive to calcofluor, SDS and growth at 42 deg; present in detergent-resistant membrane fraction (possible lipid raft component); predicted N-terminal acetylation and transmembrane helix
orf19.3350MRP20Candida albicans SC5314Component of mitochondrial ribosome; decreased expression in hyphae compared to yeast-form cells
orf19.6694Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.3352Candida albicans SC5314Protein of unknown function
orf19.3353Candida albicans SC5314Protein similar to a mitochondrial complex I intermediate-associated protein; fluconazole-repressed; Spider biofilm induced; rat catheter biofilm repressed
orf19.333FCY2Candida albicans SC5314Purine-cytosine permease of pyrimidine salvage; mutation associated with resistance to flucytosine in clinical isolates; transposon mutation affects filamentation; farnesol-upregulated in biofilm
orf19.6713WOR4Candida albicans SC5314Protein of unknown function
orf19.334Candida albicans SC5314Protein of unknown function; flow model biofilm induced; Spider biofilm induced; regulated by Sef1, Sfu1, and Hap43
orf19.335Candida albicans SC5314Sef1p-, Sfu1p-, and Hap43p-regulated gene
orf19.7371ZCF35Candida albicans SC5314Zn(II)2Cys6 transcription factor; Hap43-induced; Spider biofilm induced
orf19.6715Candida albicans SC5314Protein of unknown function
orf19.336YAH1Candida albicans SC5314Protein similar to oxidoreductases; induced in high iron; Hap43-repressed
orf19.7372MRR1Candida albicans SC5314Putative Zn(II)2Cys6 transcription factor; regulator of MDR1 transcription; gain-of-function mutations cause upregulation of MDR1 (a plasma membrane multidrug efflux pump) and multidrug resistance; Hap43-induced
orf19.6717Candida albicans SC5314Putative serine hydrolase; Spider biofilm repressed
orf19.4030Candida albicans SC5314Protein of unknown function
orf19.7374CTA4Candida albicans SC5314Zn(II)2Cys6 transcription factor; induced by nitric oxide; induced by Mnl1 under weak acid stress; repressed upon adherence to polystyrene; Hap43-repressed; Spider biofilm induced
orf19.339NDE1Candida albicans SC5314Putative NADH dehydrogenase; may act alternatively to complex I in respiration; caspofungin repressed; rat catheter biofilm induced; Spider biofilm repressed
orf19.7375Candida albicans SC5314Putative U1A component of the U1 snRNP, involved in splicing; contains two RNA recognition motifs (RRMs); ortholog of S. cerevisiae MUD1
orf19.6719Candida albicans SC5314Putative nucleosome assembly protein; homozygous transposon insertion causes decreased colony wrinkling under filamentous growth-inducing conditions, but does not block true hyphal formation in liquid media
orf19.7376Candida albicans SC5314Protein of unknown function
orf19.4033PRP22Candida albicans SC5314Putative RNA-dependent ATPase; induced upon adherence to polystyrene; induced by Mnl1p under weak acid stress
orf19.7378Candida albicans SC5314Protein of unknown function
orf19.7379FAA2Candida albicans SC5314Putative acyl CoA synthetase; expression regulated upon white-opaque switch; rat catheter biofilm induced; Spider biofilm induced
Locus IdGene NameOrganismDescription
orf19.4036APM1Candida albicans SC5314Ortholog of S. cerevisiae/S. pombe Apm1; a clathrin-associated protein complex (AP-1) subunit; phosphorylated protein; Tn mutation affects filamentous growth; Spider biofilm repressed
orf19.1491Candida albicans SC5314Protein of unknown function
orf19.1493RAD7Candida albicans SC5314Protein similar to S. cerevisiae Rad7p, which is a subunit of the Nucleotide Excision Repair Factor 4; induced under hydroxyurea treatment
orf19.1516Candida albicans SC5314Protein of unknown function
orf19.1517ARO3Candida albicans SC53143-deoxy-D-arabinoheptulosonate-7-phosphate synthase; aromatic amino acid synthesis; GCN-regulated; feedback-inhibited by phe if expressed in S. cerevisiae; decreased in stationary phase; flow model biofilm repressed
orf19.2174RAD57Candida albicans SC5314Putative DNA recombination and repair protein; induced by interaction with macrophage; transcript is regulated by Nrg1, Mig1, and Tup1; essential protein; S. cerevisiae ortholog is essential
orf19.2178MRS4Candida albicans SC5314Mitochondrial carrier family member, involved in iron homeostasis; putative membrane transporter localized to the mitochondrial membrane; transcription under control of Atf2p; regulated by Sef1p, Sfu1p, and Hap43p
orf19.2179SIT1Candida albicans SC5314Transporter of ferrichrome siderophores, not ferrioxamine B; required for human epithelial cell invasion in vitro, not for mouse systemic infection; regulated by iron, Sfu1, Rfg1, Tup1, Hap43; rat catheter and Spider biofilm induced
orf19.7401ISW2Candida albicans SC5314Ortholog of S. cerevisiae Isw2; an ATPase involved in chromatin remodeling; required for chlamydospore formation; Hap43-induced gene; repressed by high-level peroxide stress
orf19.7402DOT1Candida albicans SC5314Putative modulator of white-opaque switching
orf19.7403Candida albicans SC5314Protein of unknown function
orf19.7405Candida albicans SC5314Ortholog of Rad33; involved in nucleotide excision repair in S. cerevisiae; induced by Mnl1 under weak acid stress
orf19.7406Candida albicans SC5314Protein of unknown function
orf19.7409ERV25Candida albicans SC5314Component of COPII-coated vesicles; transcript induced upon filamentous growth; rat catheter biofilm repressed
orf19.4861Candida albicans SC5314Protein of unknown function; rat catheter biofilm repressed
orf19.4863PDC2Candida albicans SC5314Homeodomain-like transcription factor; regulator of pyruvate decarboxylase; contains a putative C-terminal activation domain, Glu- and Pro-rich; complements glucose utilization defect of S. cerevisiae pdc2 mutant
orf19.4865Candida albicans SC5314Protein of unknown function
orf19.1522Candida albicans SC5314Protein of unknown function
orf19.1523FMO1Candida albicans SC5314Putative oxidoreductase; mutation confers hypersensitivity to toxic ergosterol analog, and to amphotericin B
orf19.1524SPR3Candida albicans SC5314Septin; mutant has no obvious phenotype
Locus IdGene NameOrganismDescription
orf19.4869SFU1Candida albicans SC5314GATA-type transcription factor; regulator of iron-responsive genes; represses iron utilization genes if iron is present; Hap43-repressed; promotes gastrointestinal commensalism in mice; Spider biofilm induced
orf19.1526SNF2Candida albicans SC5314Protein involved in transcriptional regulation; ortholog of S. cerevisiae Snf2p, which is the catalytic subunit of the SWI/SNF chromatin remodeling complex; interacts with Swi1p; SWI/SNF complex is essential for hyphal growth and virulence
orf19.3593RPT6Candida albicans SC5314Putative ATPase of the 19S regulatory particle of the 26S proteasome; transcript regulated by Mig1; regulated by Gcn2 and Gcn4
orf19.2939Candida albicans SC5314Protein of unknown function
orf19.6142Candida albicans SC5314Protein of unknown function
orf19.6143Candida albicans SC5314Predicted long-chain-alcohol oxidase; Spider biofilm induced
orf19.6147Candida albicans SC5314Putative histone chaperone; role in chromatin remodeling; rat catheter and Spider biofilm repressed
orf19.2940Candida albicans SC5314Putative v-SNARE of the endoplasmic reticulum membrane; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.2941SCW4Candida albicans SC5314Putative cell wall protein; substrate for Kex2p processing in vitro; expression regulated by white-opaque switch; alkaline repressed; possibly essential (UAU1 method); flow model biofilm induced; Spider biofilm induced
orf19.2947SNZ1Candida albicans SC5314Stationary phase protein; vitamin B synthesis; induced byyeast-hypha switch, 3-AT or in azole-resistant strain overexpressing MDR1; soluble in hyphae; regulated by Gcn4, macrophage; Spider biofilm induced; rat catheter biofilm repressed
orf19.6152Candida albicans SC5314Protein of unknown function
orf19.6155Candida albicans SC5314Protein of unknown function
orf19.2952EXG2Candida albicans SC5314GPI-anchored cell wall protein, similar to S. cerevisiae exo-1,3-beta-glucosidase Exg2p; predicted Kex2p substrate; induced during cell wall regeneration; possibly an essential gene, disruptants not obtained by UAU1 method; Hap43p-repressed
orf19.2956MGM101Candida albicans SC5314Putative mitochondrial genome maintenance protein; fungal-specific (no human or murine homolog); mutation confers hypersensitivity to tubercidin (7-deazaadenosine)
orf19.2958Candida albicans SC5314Planktonic growth-induced gene
orf19.5500MAK16Candida albicans SC5314Putative constituent of 66S pre-ribosomal particles; Hap43-induced; repressed by prostaglandins; Spider biofilm induced
orf19.5501YAF9Candida albicans SC5314Subunit of the NuA4 histone acetyltransferase complex; transcript regulated by Mig1; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.5502Candida albicans SC5314Protein of unknown function
orf19.5504Candida albicans SC5314Protein of unknown function
orf19.5505HIS7Candida albicans SC5314Putative imidazole glycerol phosphate synthase; histidine biosynthesis; no human/murine homolog; transcription induced by histidine starvation; regulated by Gcn2p and Gcn4p; higher protein level in stationary phase
Locus IdGene NameOrganismDescription
orf19.6163CSE4Candida albicans SC5314Centromeric histone H3 variant; role in structural changes of centromeric nucleosomes during cell cycle; 4 nucleosomes bind 1 centromere, each has 1 Cse4 molecule during most of cell cycle, 2 molecules in anaphase; Spider biofilm repressed
orf19.5507ENP1Candida albicans SC5314Protein required for pre-rRNA processing and 40S ribosomal subunit synthesis; associated with U3 and U14 snoRNAs; transposon mutation affects filamentous growth; repressed by prostaglandins; Spider biofilm induced
orf19.6698Candida albicans SC5314Protein of unknown function
orf19.6699Candida albicans SC5314Protein of unknown function
orf19.3357Candida albicans SC5314Protein of unknown function
orf19.3358LSC1Candida albicans SC5314Putative succinate-CoA ligase subunit; induced by high iron; fluconazole-induced; protein present in exponential and stationary growth phase yeast cultures; Spider biofilm repressed
orf19.3360Candida albicans SC5314Protein of unknown function; flow model biofilm induced; Spider biofilm induced
orf19.3362Candida albicans SC5314Protein of unknown function
orf19.2708Candida albicans SC5314Protein of unknown function
orf19.2709ZUO1Candida albicans SC5314Ortholog of S. cerevisiae Zuo1; a cytosolic ribosome-associated chaperone; likely to be essential for growth, based on an insertional mutagenesis strategy; Spider biofilm repressed
orf19.3367Candida albicans SC5314Protein of unknown function
orf19.3368Candida albicans SC5314Protein of unknown function
orf19.2710Candida albicans SC5314Protein of unknown function
orf19.2712HCA4Candida albicans SC5314Putative role in regulation of cell wall biogenesis; Hap43p-induced gene; possibly an essential gene, disruptants not obtained by UAU1 method; flow model and rat catheter biofilm induced
orf19.3370DOT4Candida albicans SC5314Protein similar to ubiquitin C-terminal hydrolase; localizes to cell surface of hyphal cells, but not yeast-form cells; repressed upon high-level peroxide; Hap43p-induced; rat catheter biofilm induced
orf19.3371JAB1Candida albicans SC5314Component of the COP9 signalosome (CSN) complex, provides catalytic activity for deneddylation that cleaves the ubiquitin-like protein tag Rub1p off the cullin (Cdc53p) molecule
orf19.2717SAS10Candida albicans SC5314Putative U3-containing small subunit processome complex subunit; Hap43p-induced gene; mutation confers resistance to 5-fluorocytosine (5-FC); repressed upon high-level peroxide stress
orf19.3373Candida albicans SC5314Putative protein of unknown function; transcript upregulated in clinical isolates from HIV+ patients with oral candidiasis; Spider biofilm induced
orf19.3374ECE1Candida albicans SC5314Hypha-specific protein; regulated by Rfg1, Nrg1, Tup1, Cph1, Efg1, Hog1, farnesol, phagocytosis; fluconazole-induced; rat catheter and Spider biofilm induced; flow model biofilm repressed; Bcr1-repressed in RPMI a/a biofilms
orf19.3376Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.2720Candida albicans SC5314Cytosolic chaperonin Cct ring complex subunit; role in the assembly of actin and tubulins; Spider biofilm repressed
orf19.1494RAD23Candida albicans SC5314S. cerevisiae Rad23 ortholog; binds damaged DNA; Spider biofilm repressed
orf19.1499CTF1Candida albicans SC5314Putative zinc-finger transcription factor, similar to A. nidulans FarA and FarB; activates genes required for fatty acid degradation; induced by oleate; null mutant displays carbon source utilization defects and slightly reduced virulence
orf19.6720Candida albicans SC5314P-Loop domain-containing protein of unknown function; transposon mutation affects filamentous growth; Spider biofilm induced
orf19.341Candida albicans SC5314Putative spermidine export pump; fungal-specific (no human or murine homolog)
orf19.6722Candida albicans SC5314Protein similar to S. cerevisiae Rad4p; down-regulation associated with azole resistance
orf19.7380Candida albicans SC5314Protein of unknown function
orf19.345Candida albicans SC5314Succinate semialdehyde dehydrogenase; for utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of 4-aminobutyrate and glutamate degradation pathways; rat catheter biofilm induced
orf19.7381AHR1Candida albicans SC5314Zn(II)2Cys6 transcription factor; involved in regulation of adhesion genes; involved in white-opaque switch; forms complex with Mcm1; mutant is sensetive to 5-fluorocytosine and lithium chloride; Spider biofilm induced
orf19.7382CAM1Candida albicans SC5314Putative translation elongation factor eEF1 gamma; protein level decreased in stationary phase cultures; Spider biofilm repressed
orf19.6726Candida albicans SC5314Protein of unknown function
orf19.7383MNN9Candida albicans SC5314Protein of N-linked outer-chain mannan biosynthesis; mutant has defective cell wall; required for wild-type hyphal growth; mutant is hygromycin B sensitive and vanadate resistant; has N-terminal membrane-spanning segment (positions 18-34)
orf19.6727RIT1Candida albicans SC5314Putative initiator tRNA methionine ribosyltransferase; fungal-specific (no human or murine homolog)
orf19.4040ILV3Candida albicans SC5314Dihydroxyacid dehydratase; repressed by nitric oxide; macrophage-induced protein; protein in exponential and stationary growth phase; Sef1, Sfu1p, Hap43-regulated; farnesol-repressed; flow model biofilm induced; Spider biofilm repressed
orf19.7384NOG1Candida albicans SC5314Putative GTPase; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine); repressed by prostaglandins; Hap43-induced
orf19.7385Candida albicans SC5314CCCH zinc finger protein; Spider biofilm induced
orf19.7387ELP3Candida albicans SC5314Predicted histone acetyltransferase; role in regulation of transcription, tRNA wobble uridine modification; Spider biofilm induced
orf19.4044MUM2Candida albicans SC5314Protein similar to S. cerevisiae Mum2, a protein essential for meiotic DNA replication and sporulation; induced by alpha pheromone in SpiderM medium; transcript regulated by Tup1
orf19.4045EST1Candida albicans SC5314Telomerase subunit; allosteric activator of catalytic activity, but not required for catalytic activity; has TPR domain
orf19.4046Candida albicans SC5314Putative transcription factor containing a Zn(2)-Cys(6) binuclear cluster
Locus IdGene NameOrganismDescription
orf19.1527Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.2185NSA1Candida albicans SC5314Putative 66S pre-ribosomal particles conmponent; Hap43-induced; repressed by prostaglandins
orf19.2186SEH1Candida albicans SC5314Protein of unknown function
orf19.2187ALG7Candida albicans SC5314Protein involved in cell wall mannan biosynthesis; mutation confers hypersensitivity to tunicamycin; transcript elevated in chk1, nik1, and sln1 homozygous null mutants; possibly essential gene, disruptants not obtained by UAU1 method
orf19.7410CYM1Candida albicans SC5314Putative metalloprotease of the mitochondrial intermembrane space; rat catheter biofilm induced
orf19.7413MMS21Candida albicans SC5314Putative MMS21-SMC5-SMC6 complex component
orf19.7414ALS6Candida albicans SC5314ALS family protein; expression in S. cerevisiae confers adhesion to gelatin; macrophage-induced gene; N-terminal adhesion domain; ALS family includes cell-surface glycoproteins, some with adhesin function
orf19.7417TSA1Candida albicans SC5314TSA/alkyl hydroperoxide peroxidase C (AhPC) family protein; similar to thiol-dependent peroxidases of oxidative stress signaling; antigenic; hyphal surface, nucleus; yeast-form nucleus, cytoplasm; biofilm, phagocytosis, peroxide induced
orf19.7419HNT2Candida albicans SC5314Putative dinucleoside triphosphate hydrolase; induced upon low-level peroxide stress
orf19.4870DBP3Candida albicans SC5314Putative ATP-dependent DEAD-box RNA helicase; Hap43-induced; repressed by prostaglandins; Spider biofilm induced
orf19.4871ERO1Candida albicans SC5314Ortholog of S. cerevisiae Ero1; role in formation of disulfide bonds in the endoplasmic reticulum; fluconazole-induced; induced by Mnl1 under weak acid stress; Spider biofilm induced
orf19.4874MNN23Candida albicans SC5314Alpha-1,2-mannosyltransferase; mutants hypersensitive to toxic ergosterol analog, amphotericin B, calcofluor white, growth at 42 degrees and have decreased cell wall mannan; flow model biofilm induced
orf19.1531Candida albicans SC5314Protein of unknown function
orf19.1532SAM37Candida albicans SC5314Protein of the mitochondrial outer membrane, component of the Sorting and Assembly Machinery (SAM) involved in insertion of proteins into the outer membrane; mutants show loss of mtDNA
orf19.1533Candida albicans SC5314Possible vacuolar protein; Hap43-induced gene
orf19.1534Candida albicans SC5314Ortholog of S. cerevisiae Zrt3, vacuolar membrane zinc transporter; predicted Kex2 substrate; induced in oralpharyngeal candidasis; flow model biofilm induced; Spider biofilm induced
orf19.2191Candida albicans SC5314Protein of unknown function
orf19.1535Candida albicans SC5314Protein of unknown function; Hap43-induced gene
orf19.1536Candida albicans SC5314Putative vacuolar transporter; Hap43-induced; required for normal filamentous growth; mRNA binds She3 and is localized to hyphal tips
orf19.2194APM4Candida albicans SC5314Cargo-binding subunit of the clathrin associated protein complex (AP-2), involved in endocytosis
Locus IdGene NameOrganismDescription
orf19.6165KGD1Candida albicans SC5314Putative 2-oxoglutarate dehydrogenase; regulated by Efg1 under yeast but not hyphal growth conditions; transcript induced in an RHE model of oral candidiasis; stationary phase enriched protein; Hap43-repressed; rat catheter biofilm induced
orf19.6166Candida albicans SC5314Protein of unknown function
orf19.6168Candida albicans SC5314Protein of unknown function
orf19.2960FRS2Candida albicans SC5314Putative tRNA-Phe synthetase; downregulated upon phagocytosis by murine macrophage; protein present in exponential and stationary growth phase yeast cultures; Spider biofilm repressed
orf19.2961Candida albicans SC5314Putative transcription factor with zinc finger DNA-binding motif
orf19.2963Candida albicans SC5314Protein of unknown function
orf19.2964Candida albicans SC5314Protein of unknown function
orf19.2966Candida albicans SC5314Predicted dienelactone hydrolase domain; clade-associated gene expression; farnesol-downregulated; rat catheter biofilm repressed
orf19.2968Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.2969RAD16Candida albicans SC5314Ortholog of S. cerevisiae Rad16; a protein that recognizes and binds damaged DNA; flucytosine induced; rat catheter and Spider biofilm induced
orf19.5510Candida albicans SC5314Protein of unknown function
orf19.5513PRP45Candida albicans SC5314Protein required for pre-mRNA splicing; Spider biofilm induced
orf19.6170Candida albicans SC5314Protein of unknown function
orf19.5514Candida albicans SC5314Ortholog of S. pombe SPCC550.08, an N-acetyltransferase; transcript induced during growth in the mouse cecum
orf19.6171NUP159Candida albicans SC5314FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport; rat catheter biofilm repressed
orf19.5515Candida albicans SC5314Protein of unknown function
orf19.5516Candida albicans SC5314Protein of unknown function
orf19.6173STD1Candida albicans SC5314Putative transcription factor; involved in control of glucose-regulated gene expression; repressed by Rgt1; Spider biofilm induced
orf19.6175Candida albicans SC5314Putative 35S rRNA processing protein; Hap43-induced; repressed by prostaglandins; Spider biofilm induced
orf19.5519GCV1Candida albicans SC5314Putative T subunit of glycine decarboxylase; transcript negatively regulated by Sfu1; Spider biofilm repressed
Locus IdGene NameOrganismDescription
orf19.6176SEC61Candida albicans SC5314ER protein-translocation complex subunit; essential; 10 predicted transmembrane regions; chimeric mutant partially functionally complements S. cerevisiae sec61 defects; Spider biofilm repressed
orf19.2721Candida albicans SC5314Protein of unknown function
orf19.2722CGR1Candida albicans SC5314Negative regulator of yeast-form growth; HSP70 family member; induced by growth cessation at yeast-hyphal transition or in planktonic growth; physically interacts with Msi3p; similar to rat anti-aging gene, SMP30, stationary phase enriched
orf19.2723HIT1Candida albicans SC5314Ortholog of S. cerevisiae Hit1; protein of unknown function required for high temperature growth; flow model biofilm induced; Spider biofilm induced
orf19.2724Candida albicans SC5314Protein of unknown function; flow model, rat catheter and Spider biofilm induced; Hap43-repressed
orf19.2725Candida albicans SC5314Protein of unknown function
orf19.2731Candida albicans SC5314Protein of unknown function
orf19.2733Candida albicans SC5314Putative subunit of phosphatidylinositol 3-kinase complexes I and II; transcription is activated in the presence of elevated CO2
orf19.2734Candida albicans SC5314Protein with a glucose/ribitol dehydrogenase family domain; mutants are viable
orf19.2735SEN2Candida albicans SC5314Putative tRNA splicing endonuclease subunit; mutation confers hypersensitivity to toxic ergosterol analog and to amphotericin B; 5'-UTR intron; Hap43-induced; Spider biofilm induced
orf19.2736HFL2Candida albicans SC5314HAP5-like; ortholog of S. cerevisiae Bur6, a heterodimeric NC2 transcription regulator complex subunit; flucytosine induced
orf19.2737Candida albicans SC5314Carbohydrate kinase domain-containing protein; Spider biofilm induced
orf19.3393Candida albicans SC5314Putative DEAD-box helicase; Hap43-induced; Spider biofilm induced
orf19.3394Candida albicans SC5314Predicted membrane protein; induced by alpha pheromone in SpiderM medium
orf19.3396HCH1Candida albicans SC5314Ortholog of S. cerevisiae Hch1, a regulator of heat shock protein Hsp90; regulated by Gcn4; induced in response to amino acid starvation (3-aminotriazole treatment); mutants are viable
orf19.2743Candida albicans SC5314Protein of unknown function
orf19.2746EMP70Candida albicans SC5314Protein with a role in endosome-to-vacuole sorting; rat catheter biofilm repressed
orf19.2747RGT1Candida albicans SC5314Zn(II)2Cys6 transcription factor; transcriptional repressor involved in the regulation of glucose transporter genes; ortholog of S. cerevisiae Rgt1; mutants display decreased colonization of mouse kidneys
orf19.2749Candida albicans SC5314BTB/POZ domain protein; induced by Mnl1 under weak acid stress; flow model biofilm induced; Spider biofilm induced
orf19.2752ADR1Candida albicans SC5314C2H2 transcription factor; ortholog of S. cerevisiae Adr1 but mutant phenotype suggests a different set of target genes; transposon mutation affects filamentous growth; Spider biofilm induced
Locus IdGene NameOrganismDescription
orf19.2753ZCF15Candida albicans SC5314Predicted Zn(II)2Cys6 transcription factor of unknown function; rat catheter biofilm induced
orf19.2755Candida albicans SC5314Protein of unknown function
orf19.4048DES1Candida albicans SC5314Putative delta-4 sphingolipid desaturase; planktonic growth-induced gene
orf19.6730Candida albicans SC5314Protein of unknown function
orf19.351Candida albicans SC5314Protein of unknown function
orf19.6731Candida albicans SC5314Protein of unknown function; repressed by alpha pheromone in SpiderM medium; Spider biofilm induced
orf19.352Candida albicans SC5314Protein of unknown function
orf19.6732Candida albicans SC5314Protein of unknown function
orf19.353ULP1Candida albicans SC5314SUMO deconjugation enzyme that cleaves the small ubiquitin-like modifier (SUMO) off proteins
orf19.354Candida albicans SC5314Protein of unknown function
orf19.355Candida albicans SC5314Protein of unknown function
orf19.7391OCH1Candida albicans SC5314Alpha-1,6-mannosyltransferase; initiates N-glycan outer chain branch addition; similar to S. cerevisiae Och1p; required for wild-type virulence in mouse intravenous infection; fungal-specific (no human or murine homolog)
orf19.7392DED1Candida albicans SC5314Predicted ATP-dependent RNA helicase; RNA strand annealing activity; Spider biofilm induced
orf19.6737Candida albicans SC5314Protein of unknown function; mutants are viable; induced in a cyr1, ras1, or efg1 homozygous null
orf19.7394GDA1Candida albicans SC5314Golgi membrane GDPase, required for wild-type O-mannosylation, not N-glycosylation; required for wild-type hyphal induction, cell wall, and cell surface charge; not required for HeLa cell adherence; functional homolog of S. cerevisiae Gda1p
orf19.4051HTS1Candida albicans SC5314Putative tRNA-His synthetase; downregulated upon phagocytosis by murine macrophage; stationary phase enriched protein; Spider biofilm repressed
orf19.7395Candida albicans SC5314Protein of unknown function
orf19.359GTT12Candida albicans SC5314Protein of unknown function
orf19.4054CTA24Candida albicans SC5314Putative transcription factor; positive regulator of gene expression; Efg1-repressed; member of a family of telomere-proximal genes; transcript upregulated in RHE model of oral candidiasis
orf19.4057Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.4059Candida albicans SC5314Protein of unknown function
orf19.6740Candida albicans SC5314Protein of unknown function
orf19.362TLO9Candida albicans SC5314Member of a family of telomere-proximal genes of unknown function; Hap43p-repressed gene
orf19.2197Candida albicans SC5314Protein of unknown function
orf19.2199PHO86Candida albicans SC5314Putative endoplasmic reticulum protein; possibly adherence-induced
orf19.7420Candida albicans SC5314Protein of unknown function
orf19.7421CYP5Candida albicans SC5314Putative peptidyl-prolyl cis-trans isomerase; macrophage-downregulated protein level; protein level decrease in stationary phase cultures; predicted endoplasmic reticulum (ER) localization
orf19.7424NSA2Candida albicans SC5314Putative protein constituent of 66S pre-ribosomal particles; Hap43-induced; repressed by prostaglandins
orf19.7425Candida albicans SC5314Protein of unknown function
orf19.7426Candida albicans SC5314Protein of unknown function
orf19.7428APN1Candida albicans SC5314Ortholog of S. cerevisiae Apn1; an AP endonuclease; transcript induced by interaction with macrophages; fungal-specific (no human or murine homolog)
orf19.4880Candida albicans SC5314Protein of unknown function; flow model biofilm induced
orf19.4882Candida albicans SC5314TFIIE small subunit; involved in RNA polymerase II transcription initiation; Spider biofilm induced
orf19.4884WOR1Candida albicans SC5314Transcription factor ("master switch") of white-opaque phenotypic switching; required to establish and maintain the opaque state; opaque-specific, nuclear; regulates its own expression; suggested role in regulation of adhesion factors
orf19.4885MIR1Candida albicans SC5314Putative mitochondrial phosphate transporter; caspofungin repressed; expression is increased in a fluconazole-resistant isolate; induced upon adherence to polystyrene
orf19.1542HEX3Candida albicans SC5314Protein similar to S. cerevisiae Hex3p, which is involved in DNA damage response; transposon mutation affects filamentous growth
orf19.1543OPI1Candida albicans SC5314Leucine zipper transcription factor; repressor of INO1 involved in inositol biosynthesis; functional homolog of S. cerevisiae Opi1; has putative Opi1-Sin3 interaction domain; interacts with ScSin3, but not CaSin3
orf19.4889Candida albicans SC5314Predicted MFS family membrane transporter, member of the drug:proton antiporter (12 spanner) (DHA1) family; Spider biofilm induced
orf19.1547Candida albicans SC5314Protein of unknown function
orf19.1549Candida albicans SC5314Plasma membrane-associated protein identified in detergent-resistant membrane fraction (possible lipid raft component); repressed by nitric oxide; predicted transmembrane helix
Locus IdGene NameOrganismDescription
orf19.7433Candida albicans SC5314Protein of unknown function
orf19.7436AAF1Candida albicans SC5314Possible regulatory protein; possible adhesin-like; Glu-rich domain; production in S. cerevisiae increases endothelial cell adherence and flocculence; flow model biofilm, alkaline or caspofungin induced
orf19.6178FBP1Candida albicans SC5314Fructose-1,6-bisphosphatase; key gluconeogenesis enzyme; regulated by Efg1, Ssn6; induced by phagocytosis; effects switch from glycolysis to gluconeogenesis in macrophage; rat flow model biofilm induced; overlaps orf19.6179
orf19.2970LYS2Candida albicans SC5314Heterodimeric alpha-aminoadipate reductase large subunit; lysine biosynthesis; predicted binding sites for AMP and alpha-aminoadipate; inhibited by lys or thialysine; regulated by Gcn2 and Gcn4; Spider biofilm induced, flow model repressed
orf19.2972PDE2Candida albicans SC5314High affinity cyclic nucleotide phosphodiesterase; moderates signaling by cAMP; required for virulence, switching, cell wall, hyphal, not pseudohyphal growth; expressed shortly after hyphal induction; rat catheter and Spider biofilm induced
orf19.2974YKT6Candida albicans SC5314Putative protein of the vacuolar SNARE complex; predicted role in vacuolar fusion; rat catheter biofilm repressed
orf19.2975YPT7Candida albicans SC5314Protein of YPT/RAB family; induced during the mating process
orf19.5521ISA1Candida albicans SC5314Putative mitochondrial iron-sulfur protein; alkaline repressed; induced in high iron; regulated by Sef1, Sfu1, Hap43; Spider biofilm induced
orf19.5523Candida albicans SC5314Protein of unknown function
orf19.6180Candida albicans SC5314Protein similar to Pichia anomala YDL054c and S. cerevisiae Ydl054cp; transmembrane regions predicted; Hap43p-repressed gene
orf19.5525Candida albicans SC5314Putative oxidoreductase; protein levels affected by URA3 expression in CAI-4 strain background; Efg1, Efh1 regulated; Rgt1-repressed; protein present in exponential and stationary growth phase yeast; rat catheter biofilm repressed
orf19.6182ZCF34Candida albicans SC5314Zn(II)2Cys6 transcription factor involved in regulation of multidrug resistance via control of CDR1 expression; mutants display decreased colonization of mouse kidneys; required for yeast cell adherence to silicone substrate
orf19.6183TIM8Candida albicans SC5314Predicted mitochondrial intermembrane space protein with role in protein import into mitochondrial inner membrane and cytosol
orf19.6185Candida albicans SC5314Putative pseudouridine-5'-phosphate glycosidase; overlaps orf19.6186 and orf19.6187; Spider biofilm repressed
orf19.6186Candida albicans SC5314Predicted protein of unknown function; overlaps orf19.6185
orf19.6187Candida albicans SC5314possible pseudouridine monophosphate glycosidase; overlaps orf19.6185 and orf19.618; has intron; Spider biofilm repressed
orf19.6189Candida albicans SC5314Chalcone related protein family; flow model biofilm induced
orf19.2982Candida albicans SC5314Protein of unknown function
orf19.2984MST1Candida albicans SC5314Protein of unknown function
orf19.2986Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.2988Candida albicans SC5314Predicted aminotransferase based on S. pombe ortholog SPBC660.12c; flow model biofilm induced
orf19.2989GOR1Candida albicans SC5314Protein of unknown function
orf19.5533Candida albicans SC5314Protein of unknown function
orf19.2757Candida albicans SC5314Protein of unknown function
orf19.5300Candida albicans SC5314Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; caspofungin induced
orf19.5302PGA31Candida albicans SC5314Cell wall protein; putative GPI anchor; expression regulated upon white-opaque switch; induced by Congo Red and cell wall regeneration; Bcr1-repressed in RPMI a/a biofilms
orf19.5304Candida albicans SC5314Protein of unknown function
orf19.5306Candida albicans SC5314Protein of unknown function
orf19.5307JEN2Candida albicans SC5314Dicarboxylic acid transporter; regulated by glucose repression; induced by Rgt1; disruptants not obtained by UAU1 method; rat catheter and Spider biofilm induced
orf19.2760Candida albicans SC5314Putative mRNA cleavage and polyadenylation factor; heterozygous null mutant exhibits hypersensitivity to parnafungin and cordycepin in the C. albicans fitness test
orf19.2762AHP1Candida albicans SC5314Alkyl hydroperoxide reductase; immunogenic; fluconazole-induced; amphotericin B, caspofungin, alkaline repressed; core stress response induced; Ssk1/Nrg1/Tup1/Ssn6/Hog1 regulated; flow model biofilm induced; rat catheter biofilm repressed
orf19.2765PGA62Candida albicans SC5314Adhesin-like cell wall protein; putative GPI-anchor; fluconazole-induced; induced in high iron; induced during cell wall regeneration; Cyr1 or Ras1 repressed; Tbf1 induced
orf19.2766Candida albicans SC5314Dubious open reading frame
orf19.2768AMS1Candida albicans SC5314Putative alpha-mannosidase; transcript regulated by Nrg1; induced during cell wall regeneration; flow model biofilm induced; Spider biofilm induced
orf19.5311Candida albicans SC5314Protein of unknown function
orf19.5312MET4Candida albicans SC5314Putative transcription coactivator; predicted role in sulfur amino acid metabolism; required for yeast cell adherence to silicone substrate; Spider biofilm induced
orf19.5316FGR29Candida albicans SC5314Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth; rat catheter biofilm repressed
orf19.2770Candida albicans SC5314Protein of unknown function
orf19.2771BEM3Candida albicans SC5314Putative GTPase-activating protein (GAP) for Rho-type GTPase Cdc42p; involved in cell signaling pathways that control cell polarity; similar to S. cerevisiae Bem3p
orf19.2774LAB5Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.2775IDI1Candida albicans SC5314Protein of unknown function
orf19.2778Candida albicans SC5314Protein of unknown function; transcript is upregulated in clinical isolates from HIV+ patients with oral candidiasis
orf19.5320NCE4Candida albicans SC5314Putative RecQ-mediated genome instability protein; Hap43-repressed gene; periodic mRNA expression, peak at cell-cycle G2/M phase; flow model biofilm induced
orf19.5321Candida albicans SC5314Protein of unknown function
orf19.6742Candida albicans SC5314Protein of unknown function
orf19.3400COQ3Candida albicans SC5314Protein with a predicted role in coenzyme Q biosynthesis; transcriptionally induced by interaction with macrophages; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.3401CTA1Candida albicans SC5314Protein similar to S. cerevisiae Mos10p, which affects S. cerevisiae filamentous growth; activates transcription in 1-hybrid assay in S. cerevisiae; protein levels increase under weak acid stress; nonessential
orf19.6745TPI1Candida albicans SC5314Triose-phosphate isomerase; antigenic in mouse/human; mutation affects filamentation; macrophage-repressed; protein in exponential and stationary growth phase yeast; possibly essential; flow model biofilm induced; Spider biofilm repressed
orf19.3402FPG1Candida albicans SC5314Formamidopyrimidine DNA glycosylase, involved in repair of gamma-irradiated DNA; Hap43p-repressed gene
orf19.4060ARO4Candida albicans SC53143-deoxy-D-arabinoheptulosonate-7-phosphate synthase; aromatic amino acid biosynthesis; GCN-regulated; feedback-inhibited by tyrosine if produced in S. cerevisiae Aro3p and Aro4p catalyze same reaction; protein decreases in stationary phase
orf19.6748Candida albicans SC5314Protein of unknown function
orf19.4061Candida albicans SC5314Protein of unknown function; clade-associated gene expression
orf19.3406Candida albicans SC5314Predicted chloride transporter; member of conserved Mcm1 regulon; Spider biofilm repressed
orf19.4062TRY2Candida albicans SC5314Transcription factor; regulator of yeast form adherence; required for yeast cell adherence to silicone substrate; Spider biofilm induced
orf19.4063GPT1Candida albicans SC5314GABA/polyamine transporter; 9 to 11 membrane spanning segments; complements GABA uptake defect of an S. cerevisiae uga4 put4 gap1 triple mutant; complements growth of an S. cerevisiae spe1 mutant under polyamine limitation
orf19.3409SEC12Candida albicans SC5314Putative guanyl-nucleotide exchange factor; induced in high iron; Hap43-repressed
orf19.4067FGR18Candida albicans SC5314Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth
orf19.4069Candida albicans SC5314Protein of unknown function; repressed by alpha pheromone in SpiderM medium
orf19.371Candida albicans SC5314Protein of unknown function
orf19.372Candida albicans SC5314Putative protein of unknown function; Hap43p-repressed gene
Locus IdGene NameOrganismDescription
orf19.6752Candida albicans SC5314Protein of unknown function
orf19.3411Candida albicans SC5314Protein of unknown function
orf19.6755DLD2Candida albicans SC5314Protein of unknown function
orf19.3412ATG15Candida albicans SC5314Putative lipase; fungal-specific (no human or murine homolog); Hap43p-repressed gene
orf19.7438UBA1Candida albicans SC5314Ubiquitin-activating enzyme; protein level decreases in stationary phase cultures
orf19.4892TPK1Candida albicans SC5314cAMP-dependent protein kinase catalytic subunit; Tpk2 isoform; control of morphogenesis and stress response; WT nuclear localization requires Bcy1; produced during stationary, not exponential growth; rat catheter and Spider biofilm induced
orf19.4894Candida albicans SC5314Protein with similarity to S. cerevisiae Yer010cp, a protein of unknown function belonging to the prokaryotic RraA family; repressed by benomyl; Hap43-induced; Spider biofilm induced
orf19.1551Candida albicans SC5314Predicted protein of unknown function; overlaps CPR3/orf19.1552
orf19.1552CPR3Candida albicans SC5314Putative peptidyl-prolyl cis-trans isomerase; macrophage-induced protein; protein levels decrease in stationary phase yeast cultures; predicted mitochondrial localization; overlaps orf19.1551
orf19.1553ENT3Candida albicans SC5314Putative epsin; induced during the mating process; transcript is upregulated in an RHE model of oral candidiasis
orf19.4898Candida albicans SC5314Putative protein of unknown function; induced by prostaglandins
orf19.4899GCA1Candida albicans SC5314Extracellular/plasma membrane-associated glucoamylase; expressed in rat oral infection; regulated by carbohydrates, pH, galactose; promotes biofilm matrix formation; flow model biofilm induced; Bcr1 repressed in RPMI a/a biofilms
orf19.1557Candida albicans SC5314Protein of unknown function
orf19.1559HOM2Candida albicans SC5314Aspartate-semialdehyde dehydrogenase; forms a homodimer; conserved in bacteria, archaea, and fungi but not in mammals; ketoconazole-repressed; protein present in exponential and stationary growth phase yeast cultures; GlcNAc-induced protein
orf19.401TCP1Candida albicans SC5314Chaperonin-containing T-complex subunit, induced by alpha pheromone in SpiderM medium; stationary phase enriched protein
orf19.403PCL2Candida albicans SC5314Cyclin homolog; reduced expression observed upon depletion of Cln3; farnesol regulated; periodic mRNA expression, peak at cell-cycle G1/S phase; Hap43-induced; rat catheter biofilm repressed
orf19.405VCX1Candida albicans SC5314Putative H+/Ca2+ antiporter; Spider biofilm repressed
orf19.7441Candida albicans SC5314Protein of unknown function
orf19.406ERG1Candida albicans SC5314Squalene epoxidase, epoxidation of squalene to 2,3(S)-oxidosqualene; ergosterol biosynthesis; allylamine antifungal drug target; NADH reducing cofactor but S. cerevisiae Erg1 uses NADPH; flow model biofilm induced; Spider biofilm repressed
orf19.7442Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.407GCD6Candida albicans SC5314Ortholog of S. cerevisiae Gcd6; catalytic epsilon subunit of the translation initiation factor eIF2B; genes encoding translation factors are repressed by phagocytosis by murine macrophages
orf19.7444Candida albicans SC5314Protein of unknown function
orf19.4101Candida albicans SC5314Protein of unknown function
orf19.6190SRB1Candida albicans SC5314Essential GDP-mannose pyrophosphorylase; makes GDP-mannose for protein glycosylation; functional in S. cerevisiae psa1; on yeast-form, not hyphal cell surface; alkaline induced; induced on adherence to polystyrene; Spider biofilm repressed
orf19.6191TLO8Candida albicans SC5314Member of a family of telomere-proximal genes of unknown function; may be spliced in vivo
orf19.5535Candida albicans SC5314Predicted membrane transporter, member of the anion:cation symporter (ACS) family, major facilitator superfamily (MFS)
orf19.6193TAF145Candida albicans SC5314Protein similar to S. cerevisiae Taf145p, a component of RNA polymerase II transcription factor TFIID; flucytosine repressed; likely to be essential for growth, based on an insertional mutagenesis strategy
orf19.6195Candida albicans SC5314Protein of unknown function
orf19.6196Candida albicans SC5314Component of the SWI/SNF and RSC chromatin remodeling complexes; suggested role in chromosome maintenance; Spider biofilm induced
orf19.2990XOG1Candida albicans SC5314Exo-1,3-beta-glucanase; 5 glycosyl hydrolase family member; affects sensitivity to chitin and glucan synthesis inhibitors; not required for yeast-to-hypha transition or for virulence in mice; Hap43-induced; Spider biofilm induced
orf19.6199Candida albicans SC5314Protein of unknown function
orf19.2992RPP1ACandida albicans SC5314Conserved acidic ribosomal protein; likely role in regulation of translation elongation; interacts with Rpp2B; 1 of 4 similar C. albicans ribosomal proteins (Rpp1A, Rpp1Bp, Rpp2A, Rpp2B); Hap43-induced; Spider biofilm repressed
orf19.2995Candida albicans SC5314Protein of unknown function; induced by nitric oxide; rat catheter and Spider biofilm induced
orf19.2996Candida albicans SC5314Protein of unknown function
orf19.5541Candida albicans SC5314Protein with similarity to S. pombe Nrd1p; transcription induced upon induction of hyphal growth; regulated by Cph1p, Efg1p, Cph2p; low-level expression; alkaline upregulated; fungal-specific (no human or murine homolog)
orf19.5543Candida albicans SC5314Protein of unknown function
orf19.2200Candida albicans SC5314Protein of unknown function; rat catheter biofilm repressed
orf19.5544SAC6Candida albicans SC5314Fimbrin; actin filament bundling protein; transcript regulated by Nrg1 and Mig1; protein level decreases in stationary phase
orf19.2203Candida albicans SC5314Protein of unknown function
orf19.5547Candida albicans SC5314Protein of unknown function; Hap43-repressed gene
Locus IdGene NameOrganismDescription
orf19.2204Candida albicans SC5314Predicted membrane protein of unknown function; Spider biofilm induced
orf19.5548LYS14Candida albicans SC5314Zn(II)2Cys6 transcription factor; has similarity to S. cerevisiae Lys14, which is a transcription factor involved in the regulation of lysine biosynthesis genes
orf19.5549Candida albicans SC5314Protein of unknown function
orf19.2209YVC1Candida albicans SC5314Putative vacuolar cation channel shock; repressed by alpha pheromone in SpiderM medium; flow model biofilm repressed
orf19.5550MRT4Candida albicans SC5314Putative mRNA turnover protein; Hap43-induced; mutation confers hypersensitivity to tubercidin (7-deazaadenosine); rat catheter biofilm induced
orf19.5322Candida albicans SC5314Protein of unknown function
orf19.5323MDH1-3Candida albicans SC5314Predicted malate dehydrogenase; farnesol regulated; protein present in exponential and stationary growth phase yeast; Hap43p-repressed gene
orf19.5325KIN3Candida albicans SC5314Protein similar to S. cerevisiae Kin3p; induced under Cdc5p depletion; shows Mob2p-dependent hyphal regulation; mutants are hypersensitive to caspofungin
orf19.5328GCN1Candida albicans SC5314Protein of unknown function
orf19.2781Candida albicans SC5314Protein with predicted serine/threonine kinase and tyrosine kinase domains; possibly an essential gene, disruptants not obtained by UAU1 method; Spider biofilm induced
orf19.2785ATP7Candida albicans SC5314Putative subunit of the F1F0-ATPase complex; colony morphology-related gene regulation by Ssn6; farnesol, macrophage-downregulated protein abundance; protein present in exponential and stationary yeast growth phases; Hap43-induced
orf19.2786Candida albicans SC5314Protein of unknown function
orf19.2788Candida albicans SC5314Protein of unknown function
orf19.5335SGS1Candida albicans SC5314RecQ-related DNA helicase; Bloom's syndrome-related gene; haploinsufficient for wild-type lifespan; upregulated in farnesol treated biofilm
orf19.5337UBC15Candida albicans SC5314Putative E2 ubiquitin-conjugating enzyme
orf19.5339Candida albicans SC5314Ortholog of S. cerevisiae Spg5; required for proteasome assembly during quiescence; transcript detected on high-resolution tiling arrays; Spider biofilm induced
orf19.2791BBC1Candida albicans SC5314Putative SH3-domain-containing protein
orf19.2792IST2Candida albicans SC5314Protein of unknown function
orf19.2795LHP1Candida albicans SC5314Protein of unknown function
orf19.2797Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.5340Candida albicans SC5314Putative Rab GTPase activator; role in ER to Golgi vesicle-mediated transport; Spider biofilm induced
orf19.2000Candida albicans SC5314Protein of unknown function
orf19.2001Candida albicans SC5314Protein of unknown function
orf19.2002Candida albicans SC5314Protein of unknown function
orf19.2003HNM1Candida albicans SC5314Putative choline/ethanolamine transporter; mutation confers hypersensitivity to toxic ergosterol analog; colony morphology-related gene regulation by Ssn6; clade-associated gene expression
orf19.3578Candida albicans SC5314Protein of unknown function
orf19.2936Candida albicans SC5314Protein of unknown function
orf19.3413FGR37Candida albicans SC5314Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth
orf19.6757GCY1Candida albicans SC5314Aldo/keto reductase; mutation confers hypersensitivity to toxic ergosterol analog; farnesol-repressed; stationary phase enriched protein; flow model biofilm induced; Spider biofilm repressed
orf19.3414SUR7Candida albicans SC5314Protein required for normal cell wall, plasma membrane, cytoskeletal organization, endocytosis; localizes to eisosome subdomains of plasma membrane; four transmembrane motifs; mutant shows ectopic, chitin-rich cell wall; fluconazole-induced
orf19.4070Candida albicans SC5314Protein of unknown function
orf19.6758Candida albicans SC5314Predcted glucose 1-dehydrogenase (NADP+); rat catheter biofilm repressed
orf19.3415PTK2Candida albicans SC5314Putative protein kinase of polyamine import; mutation confers hypersensitivity to high concentrations of tunicamycin; YPD flow model biofilm induced; rat catheter and Spider biofilm induced
orf19.6759Candida albicans SC5314Protein of unknown function
orf19.4072IFF6Candida albicans SC5314Putative GPI-anchored adhesin-like protein; opaque-specific transcript; macrophage-induced gene; Hap43-repressed gene; Spider biofilm induced
orf19.3417ACF2Candida albicans SC5314Putative endo-1,3-beta-glucanase; fungal-specific (no human or murine homolog)
orf19.3418Candida albicans SC5314Protein of unknown function
orf19.3419MAE1Candida albicans SC5314Malic enzyme, mitochondrial; transcription regulated by Mig1, Tup1; colony morphology-related gene regulation by Ssn6; Hap43-repressed; Spider biofilm repressed
orf19.4076MET10Candida albicans SC5314Sulfite reductase; role in sulfur amino acid metabolism; induced by human whole blood or PMNs; Hog1-induced; possibly adherence-induced; flow model, Spider model, F-12/CO2 biofilm induced
orf19.4077MIT1Candida albicans SC5314Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; sphingolipid biosynthesis; fluconazole, caspofungin induced; macrophage-repressed; Spider biofilm induced
Locus IdGene NameOrganismDescription
orf19.4078Candida albicans SC5314Protein of unknown function
orf19.4079SLP2Candida albicans SC5314Protein similar to stomatin mechanoreception protein
orf19.382TEF2Candida albicans SC5314Translation elongation factor 1-alpha; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage
orf19.384Candida albicans SC5314Protein of unknown function
orf19.3422FMP27Candida albicans SC5314Putative mitochondrial protein; mRNA binds She3
orf19.386SAM4Candida albicans SC5314Putative S-adenosylmethionine-homocysteine methyltransferase; Hap43-repressed; alkaline induced; Spider biofilm repressed
orf19.3423TIF3Candida albicans SC5314Putative translation initiation factor; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage
orf19.3425Candida albicans SC5314RING/FYVE/PHD zinc finger protein; Spider biofilm induced
orf19.4081Candida albicans SC5314Dubious open reading frame
orf19.389Candida albicans SC5314Protein of unknown function; Hap43-induced gene
orf19.7445Candida albicans SC5314Ortholog of S.c. Vid24; a peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulated by Sef1, Sfu1, and Hap43; Spider biofilm induced
orf19.7446OPI3Candida albicans SC5314Phosphatidylethanolamine N-methyltransferase; phosphatidylcholine biosynthesis; downregulation correlates with clinical development of fluconazole resistance; amphotericin B, caspofungin repressed; Hap43-induced; Spider biofilm repressed
orf19.7447JEN1Candida albicans SC5314Lactate transporter; induced by lactic acid, activated by Cat8; alkaline repressed by Rim101; localizes to plasma membrane; Spider biofilm induced
orf19.4104Candida albicans SC5314Protein of unknown function
orf19.4105Candida albicans SC5314Protein of unknown function
orf19.7449Candida albicans SC5314Protein of unknown function
orf19.4107Candida albicans SC5314Exopolyphosphatase, hydrolyzes inorganic polyphosphate (poly P) into Pi residues; Spider biofilm repressed
orf19.1560POB3Candida albicans SC5314Protein involved in chromatin assembly and disassembly; ortholog of S. cerevisiae Pob3; transposon mutation affects filamentous growth; rat catheter biofilm repressed
orf19.1563ECM3Candida albicans SC5314Protein of unknown function
orf19.1564Candida albicans SC5314Plasma membrane-localized protein of unknown function
Locus IdGene NameOrganismDescription
orf19.1566UTP21Candida albicans SC5314Putative U3 snoRNP protein; Hap43-induce; physically interacts with TAP-tagged Nop1; Spider biofilm induced
orf19.411Candida albicans SC5314Protein similar to GTPase regulators; induced in low iron; transcript activated by Mnl1 under weak acid stress; Hap43-, Sfu1- and Sef1-regulated; flow model biofilm induced, Spider biofilm induced
orf19.413Candida albicans SC5314Protein of unknown function; induced by Sfu1; Spider biofilm induced
orf19.7450Candida albicans SC5314Protein of unknown function
orf19.7451FUN31Candida albicans SC5314Putative PAS kinase involved in cell wall damage response; similar to S. cerevisiae Psk1p, a putative serine/threonine protein kinase; induced by Mnl1 under weak acid stress; rat catheter and Spider biofilm induced
orf19.7452Candida albicans SC5314Protein of unknown function
orf19.417MTM1Candida albicans SC5314Protein of unknown function
orf19.7454TAF60Candida albicans SC5314Putative TFIID and SAGA complex subunit; mutation confers hypersensitivity to amphotericin B
orf19.419Candida albicans SC5314Protein of unknown function; flow model biofilm induced; Spider biofilm induced
orf19.7456Candida albicans SC5314Protein of unknown function; flow model biofilm repressed
orf19.7457Candida albicans SC5314Protein with Mob2p-dependent hyphal regulation
orf19.7458Candida albicans SC5314Protein of unknown function
orf19.4115Candida albicans SC5314Protein of unknown function
orf19.5552Candida albicans SC5314Putative transcriptional regulator of ribonucleotide reductase genes; Spider biofilm induced
orf19.2210Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.2211Candida albicans SC5314Protein of unknown function
orf19.2212Candida albicans SC5314Protein of unknown function
orf19.2213Candida albicans SC5314Protein of unknown function
orf19.5557MNN4-4Candida albicans SC5314Mannosyltransferase; transcript upregulated in Ssk1 response regulator mutant or in nik1 null mutant, but not in chk1 or sln1 null mutants; pheromone induced; Spider biofilm induced
orf19.5559RAV2Candida albicans SC5314Protein similar to S. cerevisiae Rav2; a regulator of (H+)-ATPase in vacuolar membrane; transposon mutation affects filamentous growth
Locus IdGene NameOrganismDescription
orf19.4900MNN12Candida albicans SC5314Predicted alpha-1,3-mannosyltransferase activity with a role in protein glycosylation
orf19.4903Candida albicans SC5314Protein of unknown function
orf19.4904Candida albicans SC5314Protein of unknown function
orf19.4906Candida albicans SC5314Putative adhesin-like protein; positively regulated by Tbf1; Spider biofilm induced
orf19.5564Candida albicans SC5314Protein of unknown function
orf19.4908Candida albicans SC5314Dubious open reading frame
orf19.5565HPD1Candida albicans SC53143-hydroxypropionate dehydrogenase; involved in degradation of toxic propionyl-CoA; rat catheter and Spider biofilm induced
orf19.2222Candida albicans SC5314Putative casein kinase; plasma membrane-localized
orf19.5567POP4Candida albicans SC5314Ortholog of S. cerevisiae Pop4; a subunit of both RNase MRP and nuclear RNase P; filament induced; regulated by Nrg1, Tup1; likely essential, based on UAU1 strategy; rat catheter and Spider biofilm induced
orf19.5568VPS51Candida albicans SC5314Protein with a role in vacuolar function; null mutant has defect in damaging oral epithelial and vascular endothelial cells; required for normal hyphal growth and stress resistance; induced in presence of host oral or vascular cells
orf19.2229Candida albicans SC5314Protein of unknown function
orf19.4911Candida albicans SC5314BED zinc finger protein; predicted DNA binding protein; Spider biofilm repressed
orf19.4912Candida albicans SC5314Protein of unknown function
orf19.4914Candida albicans SC5314Protein of unknown function
orf19.4916Candida albicans SC5314Protein of unknown function; induced by alpha pheromone in SpiderM medium
orf19.4917Candida albicans SC5314Protein of unknown function
orf19.2005REG1Candida albicans SC5314Putative protein phosphatase regulatory subunit; Hap43-repressed gene; macrophage/pseudohyphal-induced; possibly regulated upon hyphal formation; flow model biofilm induced
orf19.2006Candida albicans SC5314Protein of unknown function
orf19.2008Candida albicans SC5314Protein of unknown function
orf19.2009PEX12Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.5351TIF11Candida albicans SC5314Translation initiation factor eIF1a; possibly transcriptionally regulated upon hyphal formation; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage
orf19.5353Candida albicans SC5314Protein of unknown function
orf19.2010Candida albicans SC5314Protein of unknown function
orf19.2013KAR2Candida albicans SC5314Similar to Hsp70 family chaperones; role in translocation of proteins into the ER; induced in high iron; protein present in exponential and stationary growth phase yeast cultures; flow model and Spider biofilm repressed
orf19.5357AKL1Candida albicans SC5314Putative serine/threonine protein kinase; induced during the mating process
orf19.5358Candida albicans SC5314Phosphorylated protein of unknown function
orf19.2017Candida albicans SC5314Protein of unknown function
orf19.2019Candida albicans SC5314Protein of unknown function
orf19.5360RPC11Candida albicans SC5314Putative RNA polymerase III subunit C11; repressed in core caspofungin response; Spider biofilm induced
orf19.4704ARO1Candida albicans SC5314Putative pentafunctional arom enzyme; fungal-specific (no human or murine homolog); Gcn2p-, Gcn4p-regulated
orf19.4705Candida albicans SC5314Protein of unknown function
orf19.5362PSO2Candida albicans SC5314Putative DNA cross-link repair protein; expressed in opaque or white MTLa/MTLa or MTLalpha/MTLalpha, but not MTLa/MTLalpha cells; telomere-proximal gene; mutation does not affect white-to-opaque phenotypic switching
orf19.5363Candida albicans SC5314Component of UDP-GlcNAc transferase; required for the 2nd step of dolichyl-linked oligosaccharide synthesis; Spider biofilm induced
orf19.2020HGT6Candida albicans SC5314Putative high-affinity MFS glucose transporter; 20 family members; induced in core stress response; fluconazole, oralpharyngeal candidasis induced; flow model biofilm induced; Spider biofilm induced
orf19.4707Candida albicans SC5314Putative secreted acid sphingomyelin phosphodiesterase; possible Kex2p substrate
orf19.5367RDH54Candida albicans SC5314Putative DNA-dependent ATPase with a predicted role in DNA recombination and repair; transcriptionally induced by interaction with macrophages
orf19.2024Candida albicans SC5314Protein of unknown function
orf19.2025Candida albicans SC5314Dubious open reading frame
orf19.3427Candida albicans SC5314Protein of unknown function
orf19.4084KIS1Candida albicans SC5314Snf1p complex scaffold protein; similar to S. cerevisiae Gal83p and Sip2p with regions of similarity to Sip1p (ASC and KIS domain); interacts with Snf4p; mutants are hypersensitive to caspofungin and hydrogen peroxide; Hap43p-repressed gene
Locus IdGene NameOrganismDescription
orf19.4085Candida albicans SC5314Protein of unknown function; transcript detected on high-resolution tiling arrays
orf19.4086Candida albicans SC5314Protein of unknown function
orf19.4089SGT1Candida albicans SC5314Putative co-chaperone protein with a predicted role in kinetochore assembly; mutation confers hypersensitivity to radicicol; sumoylation target
orf19.392Candida albicans SC5314Protein of unknown function
orf19.394Candida albicans SC5314Putative kynureninase; predicted role in NAD biosynthesis; Hap43-repressed gene; flow model biofilm induced
orf19.3430Candida albicans SC5314Plasma membrane-associated protein; physically interacts with TAP-tagged Nop1p
orf19.395ENO1Candida albicans SC5314Enolase; glycolysis and gluconeogenesis; major cell-surface antigen; binds host plasmin/plasminogen; immunoprotective; Hap43, phagocytosis induced; farnesol-repressed; flow model biofilm induced; Spider biofilm repressed; may be essential
orf19.6776GCD2Candida albicans SC5314Putative translation initiation factor; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage
orf19.396EAF6Candida albicans SC5314Subunit of the NuA4 histone acetyltransferase complex; Hap43-repressed; Spider biofilm repressed
orf19.6777Candida albicans SC5314Protein of unknown function
orf19.3434TRY5Candida albicans SC5314Zn(II)2Cys6 transcription factor; regulator of yeast form adherence; required for yeast cell adherence to silicone substrate
orf19.6778Candida albicans SC5314Aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; flow model biofilm repressed
orf19.398Candida albicans SC5314Protein of unknown function
orf19.4091MED18Candida albicans SC5314RNA polymerase II mediator complex subunit; rat catheter biofilm repressed
orf19.3436Candida albicans SC5314Protein with a Rho GDP-dissociation inhibitor domain; macrophage-induced gene
orf19.3437Candida albicans SC5314Protein of unknown function
orf19.3438Candida albicans SC5314Protein of unknown function
orf19.4094Candida albicans SC5314Protein of unknown function
orf19.4095Candida albicans SC5314Protein of unknown function
orf19.4099ECM17Candida albicans SC5314Putative sulfite reductase beta subunit; role in cell wall biogenesis; regulated by Tsa1/Tsa1B in H2O2 stress; Gcn4-regulated; Tbf1-activated; Hap43-repressed; Spider, flow, F-12/CO2 model biofilm induced
Locus IdGene NameOrganismDescription
orf19.1571ATO7Candida albicans SC5314Putative fungal-specific transmembrane protein
orf19.1573Candida albicans SC5314Protein of unknown function
orf19.1575PRS1Candida albicans SC5314Phosphoribosylpyrophosphate synthetase; enzyme of purine, pyrimidine, histidine, and tryptophan biosynthesis; essential; flucytosine induced; macrophage/pseudohyphal-induced
orf19.1576Candida albicans SC5314Protein of unknown function
orf19.6801RPD31Candida albicans SC5314Putative histone deacetylase; involved in regulation of white-opaque switch; Spider biofilm repressed
orf19.422SPT20Candida albicans SC5314Putative transcription factor; downregulated upon adherence to polystyrene; flucytosine repressed
orf19.6802Candida albicans SC5314Protein of unknown function
orf19.423Candida albicans SC5314Protein of unknown function
orf19.6803HUT1Candida albicans SC5314Protein of unknown function
orf19.424TRP99Candida albicans SC5314Putative thioredoxin peroxidase/alkyl hydroperoxide reductase; induced in low iron; regulated by Gcn4; induced in response to amino acid starvation (3-AT treatment)
orf19.7460Candida albicans SC5314Putative 2'-O-methyltransferase with a predicted role in tRNA modification; transcription is activated in the presence of elevated CO2
orf19.6804Candida albicans SC5314Protein of unknown function
orf19.425Candida albicans SC5314Protein of unknown function
orf19.6805Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.7463Candida albicans SC5314Protein of unknown function
orf19.6807Candida albicans SC5314Predicted ORF in retrotransposon Tca17 with similarity to parts of the Gag-Pol region of retrotransposons; clade-associated gene expression
orf19.428Candida albicans SC5314Putative serine/threonine kinase; induced during planktonic growth; rat catheter biofilm repressed
orf19.4120LAS1Candida albicans SC5314Putative bud formation and morphogenesis protein; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU); macrophage-induced; Spider biofilm induced
orf19.4116Candida albicans SC5314Protein of unknown function
orf19.5572Candida albicans SC5314Protein of unknown function; Spider biofilm repressed
Locus IdGene NameOrganismDescription
orf19.4097Candida albicans SC5314Protein of unknown function
orf19.5574Candida albicans SC5314Protein of unknown function
orf19.4918Candida albicans SC5314Protein of unknown function
orf19.5575Candida albicans SC5314Putative peripheral peroxisomal membrane peroxin; required for regulating peroxisome size and maintenance; Spider biofilm induced
orf19.2232RPL11Candida albicans SC5314Ribosomal protein; repressed by phagocytosis; colony morphology-related gene regulation by Ssn6; Hap43-induced; Spider biofilm repressed
orf19.2233PRE2Candida albicans SC5314Putative proteasome beta-5 subunit; macrophage-induced protein
orf19.5578Candida albicans SC5314Protein of unknown function
orf19.5579Candida albicans SC5314Protein with a predicted double-strand break repair domain; Hap43-repressed gene
orf19.2236FHL1Candida albicans SC5314Fork-head transcription factor; forms a heterodimer with Ifh1 that is tethered to promoters by Tbf1; positively regulates rRNA and ribosomal protein gene transcription
orf19.2237SPR1Candida albicans SC5314Putative GPI-anchored protein; similar but not orthologous to S. cerevisiae Spr1, a sporulation-specific exo-1,3-beta-glucanase; mutant is viable
orf19.2238LTE1Candida albicans SC5314Protein similar to GDP/GTP exchange factors; repressed by alpha pheromone in SpiderM medium; flow model biofilm repressed
orf19.4921Candida albicans SC5314Protein of unknown function
orf19.4922Candida albicans SC5314Protein of unknown function
orf19.4924Candida albicans SC5314Protein of unknown function; repressed in ssr1 mutant; Spider biofilm induced
orf19.4927BNI1Candida albicans SC5314Formin; role in cytoskeletal organization, cell polarity; role in systemic virulence in mouse; cell-cycle regulated localization to site of polarized growth, bud neck; localizes to Spitzenkorper of hyphae, minor localization at septum
orf19.5584PEP3Candida albicans SC5314Peptidase; activity useful for strain identification by multilocus enzyme electrophoresis (MLEE); clade-associated gene expression
orf19.2241PST1Candida albicans SC5314Putative 1,4-benzoquinone reductase; hyphal-induced; regulated by Cyr1, Ras1, Efg1, Nrg1, Rfg1, Tup1; Hap43-induced; Spider biofilm induced
orf19.5585SAP5Candida albicans SC5314Secreted aspartyl proteinase; sap4,5,6 triple null defective in utilization of protein as N source; virulence role effected by URA3; expressed during infection; mRNA localized to hyphal tip via She3; rat catheter and Spider biofilm induced
orf19.2242PRB1Candida albicans SC5314Endoprotease B; regulated by heat, carbon source (GlcNAc-induced), nitrogen, macrophage response, human neutrophils; similar to (does not replace) S. cerevisiae vacuolar B protease Prb1p; flow model biofilm induced; Spider biofilm induced
orf19.5369Candida albicans SC5314Uroporphyrinogen decarboxylase; catalyzes the 5th step in the heme biosynthetic pathway; flow model and Spider biofilm repressed
Locus IdGene NameOrganismDescription
orf19.2028MXR1Candida albicans SC5314Putative methionine sulfoxide reductase; Plc1-regulated; induced by human neutrophils, flucytosine; macrophage regulated (gene induced, protein decreased); possibly adherence-induced; Spider biofilm induced
orf19.4711Candida albicans SC5314Protein of unknown function
orf19.4712FGR6-3Candida albicans SC5314Protein lacking an ortholog in S. cerevisiae; member of a family encoded by FGR6-related genes in the RB2 repeat sequence; transposon mutation affects filamentous growth
orf19.4715Candida albicans SC5314Protein of unknown function
orf19.4718TRP5Candida albicans SC5314Predicted tryptophan synthase; identified in detergent-resistant membrane fraction (possible lipid raft component); predicted N-terminal acetylation; Gcn4p-regulated; S. cerevisiae ortholog is Gcn4p regulated; upregulated in biofilm;
orf19.4719CWH41Candida albicans SC5314Processing alpha glucosidase I, involved in N-linked protein glycosylation and assembly of cell wall beta 1,6 glucan; rat catheter biofilm repressed
orf19.2033PGA19Candida albicans SC5314Putative GPI-anchored protein; macrophage-induced gene; mutants are viable
orf19.2034Candida albicans SC5314Protein of unknown function
orf19.2035Candida albicans SC5314Protein of unknown function
orf19.5379ERG4Candida albicans SC5314Protein similar to sterol C-24 reductase; shows Mob2p-dependent hyphal regulation; fluconazole-induced; caspofungin repressed; rat catheter biofilm repressed
orf19.2037Candida albicans SC5314Protein of unknown function
orf19.2039MSF1Candida albicans SC5314Putative phenylalanine-tRNA ligase; protein level decreases in stationary phase cultures; Hap43p-repressed gene
orf19.4721Candida albicans SC5314Protein of unknown function
orf19.4722RTG1Candida albicans SC5314Protein of unknown function
orf19.5380LYS144Candida albicans SC5314Zn(II)2Cys6 transcription factor; has similarity to S. cerevisiae Lys14, involved in the regulation of lysine biosynthesis genes
orf19.4724Candida albicans SC5314Protein of unknown function
orf19.4725SWI6Candida albicans SC5314Putative component of the MBF and SBF transcription complexes involved in G1/S cell-cycle progression; periodic mRNA expression, peak at cell-cycle G1/S phase
orf19.5383PMA1Candida albicans SC5314Plasma membrane H(+)-ATPase; highly expressed, comprises 20-40% of total plasma membrane protein; levels increase at stationary phase transition; fluconazole induced; caspofungin repressed; upregulated in RHE model; Spider biofilm repressed
orf19.4727Candida albicans SC5314Protein of unknown function
orf19.6780MET8Candida albicans SC5314Putative bifunctional dehydrogenase and ferrochelatase with a predicted role in siroheme biosynthesis; regulated by Gcn2p and Gcn4p
Locus IdGene NameOrganismDescription
orf19.6781ZFU2Candida albicans SC5314Zn(II)2Cys6 transcription factor; regulator of yeast form adherence; mutants display increased colonization of mouse kidneys; required for yeast cell adherence to silicone substrate; Spider biofilm induced
orf19.6782BMT1Candida albicans SC5314Beta-mannosyltransferase, required for addition of the 1st beta-mannose residue to acid-stable fraction of cell wall phosphopeptidomannan; 9-gene family member; mutants induce higher levels of inflammatory cytokines in mouse dendritic cells
orf19.6783Candida albicans SC5314Putative geranylgeranyltransferase regulatory component
orf19.3440FRP5Candida albicans SC5314Protein with a GPR1/FUN34/yaaH family domain; flucytosine repressed
orf19.6784PGA32Candida albicans SC5314Putative GPI-anchored adhesin-like protein; induced in high iron; Spider biofilm induced
orf19.3441FRP6Candida albicans SC5314Putative ammonia transport protein; regulated by Nrg1 and Tup1; regulated by Ssn6; induced by human neutrophils
orf19.6785RPS12Candida albicans SC5314Acidic ribosomal protein S12; regulated by Gcn4, activated by Tbf1; repressed by amino acid starvation (3-AT); protein abundance is affected by URA3 expression in CAI-4 strain background; sumoylation target; Spider biofilm repressed
orf19.3442Candida albicans SC5314Putative oxidoreductase; Hap43-repressed gene
orf19.6786Candida albicans SC5314Protein of unknown function; flow model biofilm induced
orf19.6787Candida albicans SC5314Protein of unknown function
orf19.3444Candida albicans SC5314Predicted membrane transporter, member of the drug:proton antiporter (14 spanner) (DHA2) family, major facilitator superfamily (MFS); Hap43p-repressed gene
orf19.3445HOC1Candida albicans SC5314Protein with similarity to mannosyltransferases; similar to S. cerevisiae Hoc1p and C. albicans Och1p
orf19.3446Candida albicans SC5314Protein of unknown function
orf19.3449Candida albicans SC5314Protein of unknown function
orf19.6791HHT1Candida albicans SC5314Putative histone H3; reduced mRNA abundance in fkh2 mutant; farnesol regulated; Spider biofilm induced; rat catheter biofilm repressed
orf19.6793Candida albicans SC5314Protein of unknown function; Sef1, Sfu1, and Hap43 regulated; rat catheter and Spider biofilm induced
orf19.6796YSA1Candida albicans SC5314Predicted Nudix hydrolase family member with ADP-ribose pyrophosphatase activity; role in metabolism of O-acetyl-ADP-ribose to AMP and acetylated ribose 5'-phosphate; rat catheter biofilm repressed
orf19.6797Candida albicans SC5314Protein of unknown function
orf19.7464Candida albicans SC5314Putative subtilisin-family protease; mutation confers hypersensitivity to toxic ergosterol analog
orf19.4121Candida albicans SC5314Predicted thioesterase/thiol ester dehydrase-isomerase; Spider biofilm induced
Locus IdGene NameOrganismDescription
orf19.4122Candida albicans SC5314Protein of unknown function
orf19.7466ACC1Candida albicans SC5314Putative acetyl-coenzyme-A carboxylases; regulated by Efg1; amphotericin B repressed; caspofungin repressed; 5'-UTR intron; gene used for strain identification by multilocus sequence typing; Hap43-induced; flow model biofilm repressed
orf19.4123Candida albicans SC5314Putative THO complex subunit; possibly an essential gene, disruptants not obtained by UAU1 method; protein newly produced during adaptation to the serum
orf19.4125PZF1Candida albicans SC5314C2H2 transcription factor; Hap43-induced; rat catheter and Spider biofilm induced
orf19.7469ARG1Candida albicans SC5314Argininosuccinate synthase; arginine synthesis; Gcn4, Rim101 regulated; induced by amino acid starvation (3-AT), benomyl treatment; stationary phase enriched protein; repressed in alkalinizing medium; rat catheter, Spider biofilm induced
orf19.4127Candida albicans SC5314Protein of unknown function
orf19.1581Candida albicans SC5314Planktonic growth-induced gene
orf19.1586FGR22Candida albicans SC5314Putative phosphatidylinositol-specific phospholipase C (PI-PLC); predicted type 2 membrane protein; no S. cerevisiae ortholog; role in, and regulated by, filamentation, Hap43p; almost identical to orf19.5797
orf19.1588Candida albicans SC5314Putative mitochondrial protein of unknown function; regulated by Sef1p-, Sfu1p-, and Hap43p
orf19.6811ISA2Candida albicans SC5314Protein required for maturation of mitochondrial [4Fe-4S] proteins; role in biotin biosynthetic process; rat catheter and Spider biofilm induced
orf19.6812PMT2Candida albicans SC5314Protein mannosyltransferase (PMT) with roles in hyphal growth and drug sensitivity; member of the PMT family which includes Pmt1p, Pmt2p, Pmt4p, Pmt5p, and Pmt6p; induced during cell wall regeneration; essential
orf19.433Candida albicans SC5314Protein of unknown function
orf19.434PRD1Candida albicans SC5314Putative proteinase; transcript regulated by Nrg1, Mig1, and Tup1; Hogp-induced; stationary phase enriched protein; Hap43-repressed; rat catheter biofilm repressed
orf19.7472IFF4Candida albicans SC5314Adhesin-like cell surface protein; putative GPI-anchor; null mutant germ tubes show decreased adhesion to plastic substrate; mutants are viable; Hap43-repressed gene
orf19.6816Candida albicans SC5314Putative xylose and arabinose reductase; flow model biofilm induced; Spider biofilm repressed
orf19.6817FCR1Candida albicans SC5314Transcription factor; repressor of fluconazole/ketoconazole/brefeldin A resistance; Tn mutation enhances filamentation; partially rescues S. cerevisiae pdr1 pdr3 fluconazole sensitivity; rat catheter biofilm induced/Spider biofilm repressed
orf19.6818Candida albicans SC5314Protein of unknown function
orf19.4131Candida albicans SC5314Protein of unknown function
orf19.2245YPT72Candida albicans SC5314Vacuolar Rab small monomeric GTPase involved in vacuolar biogenesis; involved in filamentous growth and virulence
orf19.5589Candida albicans SC5314Protein of unknown function; transcript detected on high-resolution tiling arrays
Locus IdGene NameOrganismDescription
orf19.2247Candida albicans SC5314Protein of unknown function
orf19.2249Candida albicans SC5314Putative metalloprotease of the mitochondrial inner membrane; expression downregulated in an ssr1 null mutant
orf19.4930SPC3Candida albicans SC5314Essential protein; similar to S. cerevisiae Spc3p, a component of the signal peptidase complex required for signal peptidase activity; predicted integral ER membrane protein; complements spc3 and suppresses sec61 S. cerevisiae mutants
orf19.4932Candida albicans SC5314Protein of unknown function
orf19.4934OP4Candida albicans SC5314Ala- Leu- and Ser-rich protein; secreted; N-terminal hydrophobic region; possible glycosylation; opaque-specific transcript; repressed by alpha pheromone in opaque MTLa homozygotes; fluconazole-induced; Spider biofilm induced
orf19.5591ADO1Candida albicans SC5314Adenosine kinase; heterozygous null mutant is resistant to cordycepin in C. albicans fitness test; ketoconazole-induced; protein level decrease in stationary phase cultures; sumoylation target; Spider biofilm repressed
orf19.4936Candida albicans SC5314Dubious open reading frame
orf19.2252Candida albicans SC5314Protein of unknown function; rat catheter biofilm repressed
orf19.5599MDL2Candida albicans SC5314Putative mitochondrial, half-size MDR-subfamily ABC transporter
orf19.2257Candida albicans SC5314Predicted ER protein involved in ER-nucleus signaling; Spider biofilm repressed
orf19.4940Candida albicans SC5314Putative histidine permease; fungal-specific (no human or murine homolog); Hap43p-induced gene
orf19.4942Candida albicans SC5314Protein of unknown function
orf19.1600Candida albicans SC5314Protein of unknown function
orf19.1601RPL3Candida albicans SC5314Ribosomal protein, large subunit; induced by ciclopirox olamine treatment; genes encoding cytoplasmic ribosomal subunits are downregulated upon phagocytosis by murine macrophages; Hap43-induced gene; Spider biofilm repressed
orf19.4946Candida albicans SC5314Protein of unknown function
orf19.2260Candida albicans SC5314Putative transcription factor with zinc finger DNA-binding motif
orf19.4948REX3Candida albicans SC5314Protein of unknown function
orf19.2261Candida albicans SC5314Protein of unknown function
orf19.4949Candida albicans SC5314Protein of unknown function
orf19.5384CHS8Candida albicans SC5314Chitin synthase required for synthesis of long-chitin fibrils; nonessential; 8 or 9 membrane spanning regions; mRNA present in yeast and hyphae; induced during cell wall regeneration; flow model biofilm repressed
Locus IdGene NameOrganismDescription
orf19.4728Candida albicans SC5314Protein of unknown function
orf19.2043Candida albicans SC5314Protein of unknown function
orf19.2044PGA27Candida albicans SC5314Putative GPI-anchored protein
orf19.5388SWD1Candida albicans SC5314Protein of unknown function
orf19.5389FKH2Candida albicans SC5314Forkhead transcription factor; morphogenesis regulator; required for wild-type hyphal transcription, cell separation, and for virulence in cell culture; mutant lacks true hyphae, is constitutively pseudohyphal; upregulated in RHE model
orf19.2047Candida albicans SC5314Putative protein of unknown function; Hap43p-repressed gene; mutation confers hypersensitivity to toxic ergosterol analog, and to amphotericin B
orf19.2049Candida albicans SC5314Plasma membrane-associated protein; heterozygous null mutant displays sensitivity to virgineone; Spider biofilm induced
orf19.4730Candida albicans SC5314Protein of unknown function
orf19.4732SEC24Candida albicans SC5314Protein with a possible role in ER to Golgi transport; induced upon yeast-hyphal switch; sumoylation target; Spider biofilm repressed
orf19.5390Candida albicans SC5314Protein of unknown function
orf19.5391Candida albicans SC5314Predicted RNA splicing and ER to Golgi transport protein; Hap43-induced gene
orf19.4735Candida albicans SC5314Ornithine cyclodeaminase family protein; Sef1, Sfu1, and Hap43-regulated; ortholog of S. cerevisiae YGL159W and S. pombe SPAP11E10.01; rat catheter biofilm induced
orf19.5392NGT1Candida albicans SC5314N-acetylglucosamine (GlcNAc)-specific transporter; role in GlcNAc (but not serum) induced hyphal growth; localizes to plasma membrane; induced by GlcNAc, macrophage engulfment; 12 transmembrane, major facilitator superfamily
orf19.4736Candida albicans SC5314Protein of unknown function
orf19.5393Candida albicans SC5314Putative cysteine sulfinate decarboxylase; transcript positively regulated by Tbf1; Spider biofilm induced
orf19.2050Candida albicans SC5314Protein of unknown function
orf19.4737TPO3Candida albicans SC5314Putative polyamine transporter; MFS-MDR family; induced by Sfu1, regulated upon white-opaque; decreased expression in hyphae vs yeast-form cells; regulated by Nrg1; Spider biofilm repressed
orf19.2051Candida albicans SC5314Protein of unknown function
orf19.3455Candida albicans SC5314Putative mitochondrial inner membrane magnesium transporter; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.3459Candida albicans SC5314Putative serine/threonine/tyrosine (dual-specificity) kinase; disruptants not obtained by UAU1 method
Locus IdGene NameOrganismDescription
orf19.6001SAP3Candida albicans SC5314Secreted aspartyl proteinase, acts in utilization of protein as nitrogen source; assessment of virulence role complicated by URA3 effects; regulated by growth phase; produced by opaque phase cells; alpha-pheromone repressed
orf19.6003Candida albicans SC5314Protein of unknown function; role in intracellular signal transduction; Spider biofilm induced
orf19.6005HGT5Candida albicans SC5314Putative glucose transporter of the major facilitator superfamily; the C. albicans glucose transporter family comprises 20 members; 12 probable membrane-spanning segments, extended N terminus; expressed in rich medium; Hap43p-repressed
orf19.6009SET1Candida albicans SC5314Lysine histone methyltransferase; methylates histone H3 K4; regulates of white-opaque switch, epithelial cell adhesion, agar-embedded filamentation, virulence in mice; unique N-terminus immunogenic in human; rat catheter biofilm repressed
orf19.2803HEM13Candida albicans SC5314Coproporphyrinogen III oxidase; antigenic; on yeast cell surface, not hyphae; iron-regulated expression; Hap43, macrophage-repressed; farnesol-induced; possibly essential; flow model biofilm induced; rat catheter, Spider biofilm repressed
orf19.3460Candida albicans SC5314Protein of unknown function; mRNA binds She3; transcript regulated upon yeast-hypha switch; induced in oralpharyngeal candidasis
orf19.3461Candida albicans SC5314Protein of unknown function; oxidative stress-induced via Cap1; induced by alpha pheromone in SpiderM medium
orf19.3463Candida albicans SC5314Putative GTPase; role in 60S ribosomal subunit biogenesis; Spider biofilm induced
orf19.2809CTN3Candida albicans SC5314Peroxisomal carnitine acetyl transferase; no obvious metabolic, hyphal, virulence defects in Ura+ strain; induced by macrophage engulfment, hyphal growth, starvation, nonfermentable carbon sources; rat catheter, Spider biofilm induced
orf19.3465RPL10ACandida albicans SC5314Predicted ribosomal protein; downregulated upon phagocytosis by murine macrophages; Hap43-induced; Spider biofilm repressed
orf19.3467SEC27Candida albicans SC5314Protein of unknown function
orf19.6010CDC5Candida albicans SC5314Polo-like kinase; member of conserved Mcm1 regulon; depletion causes defects in spindle elongation and Cdc35-dependent filamentation; virulence-group-correlated expression; likely essential (UAU1 method); Spider biofilm repressed
orf19.6012Candida albicans SC5314Protein of unknown function
orf19.6016Candida albicans SC5314Protein of unknown function
orf19.6018LRO1Candida albicans SC5314Acyltransferase that catalyzes diacylglycerol esterification of phospholipids; role in lipid storage, triglyceride biosynthesis; flow model biofilm repressed
orf19.2812Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.3470Candida albicans SC5314Putative flavodoxin; similar to S. cerevisiae Tyw1, an iron-sulfur protein required for synthesis of wybutosine modified tRNA; predicted Kex2p substrate; Spider biofilm induced
orf19.1067GPM2Candida albicans SC5314Putative phosphoglycerate mutase; repressed in hyphae; macrophage/pseudohyphal-repressed; induced by high levels of peroxide stress, farnesol; flow model biofilm induced; rat catheter and Spider biofilm repressed
orf19.3753SEF1Candida albicans SC5314Zn2-Cys6 transcription factor; regulates iron uptake; negatively regulated by Sfu1p, positively regulated by Tbf1; promotes virulence in mice; mutants display decreased colonization of mouse kidneys; Spider biofilm induced
orf19.3756CHR1Candida albicans SC5314Predicted DEAD-box ATP-dependent RNA helicase; functional homolog of S. cerevisiae Rok1; Hap43-induced; Spider biofilm induced
Locus IdGene NameOrganismDescription
orf19.1070Candida albicans SC5314Protein of unknown function
orf19.3759Candida albicans SC5314Putative elongator complex subunit; for modification of wobble nucleosides in tRNA; Spider biofilm induced
orf19.1075Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.1078HBR2Candida albicans SC5314Putative alanine glyoxylate aminotransferase; regulated by Gcn4p and hemoglobin; stationary phase enriched protein
orf19.6302PGA39Candida albicans SC5314Putative GPI-anchored protein
orf19.6305Candida albicans SC5314Hydroxytrimethyllysine aldolase, the second enzyme in the carnitine biosynthesis pathway; rat catheter biofilm repressed
orf19.6308Candida albicans SC5314Protein of unknown function
orf19.3760DLH1Candida albicans SC5314Functional homolog of S. cerevisiae Dmc1; a meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes
orf19.3763Candida albicans SC5314Protein of unknown function
orf19.3765RAX2Candida albicans SC5314Plasma membrane protein involved in establishment of bud sites and linear direction of hyphal growth; filament induced, repressed by Rim101, Tup1; Hap43-induced; Spider biofilm induced
orf19.1082Candida albicans SC5314Protein with an Alba DNA/RNA-binding protein domain; Spider biofilm induced
orf19.1085Candida albicans SC5314Protein of unknown function
orf19.1087Candida albicans SC5314Protein of unknown function
orf19.6311Candida albicans SC5314Protein of unknown function; Hap43-induced; rat catheter and Spider biofilm induced
orf19.6313MNT4Candida albicans SC5314Predicted alpha-1,3-mannosyltransferase with a role in protein glycosylation; induced in low iron
orf19.6316Candida albicans SC5314Predicted membrane transporter, member of the L-amino acid transporter-3 (LAT3) family, major facilitator superfamily (MFS)
orf19.6472CYP1Candida albicans SC5314Peptidyl-prolyl cis-trans isomerase; cyclosporin A sensitive activity; soluble in hyphae; biofilm induced, macrophage-induced protein; downregulated upon treatment of biofilm with farnesol; present in exponential and stationary phase cells
orf19.3130Candida albicans SC5314Ortholog of S. cerevisiae Gpn3 a GTPase with a role in biogenesis of RNA pol II and polIII; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.5818SUR2Candida albicans SC5314Putative ceramide hydroxylase; predicted enzyme of sphingolipid biosynthesis; regulated by Tsa1, Tsa1B under H2O2 stress conditions; Spider and flow model biofilm induced
orf19.6476Candida albicans SC5314Putative protein with a predicted role in exocytic transport from the Golgi; filament induced
Locus IdGene NameOrganismDescription
orf19.6477Candida albicans SC5314Protein of unknown function
orf19.5825NCB2Candida albicans SC5314Beta subunit of NC2, heterodimeric regulator of transcription; activates CDR1 transcription; possibly an essential gene, disruptants not obtained by UAU1 method; conditional mutants show decreased susceptibility to azoles
orf19.5826Candida albicans SC5314Predicted amino acid transmembrane transporter; rat catheter biofilm repressed
orf19.6484Candida albicans SC5314Protein of unknown function
orf19.3142Candida albicans SC5314Protein of unknown function
orf19.6488Candida albicans SC5314Protein of unknown function
orf19.3147Candida albicans SC5314Protein of unknown function
orf19.3149LSP1Candida albicans SC5314Eisosome component with a predicted role in endocytosis; protein present in exponential and stationary growth phase yeast cultures; caspofungin repressed; biofilm induced; fungal-specific (no human/murine homolog); sumoylation target
orf19.5832HPT1Candida albicans SC5314Putative hypoxanthine-guanine phosphoribosyltransferase; protein abundance affected by URA3 expression in the CAI4 strain background; protein level decreases in stationary phase; Spider biofilm induced
orf19.5834Candida albicans SC5314Protein of unknown function
orf19.5835Candida albicans SC5314Protein of unknown function
orf19.5837Candida albicans SC5314Protein of unknown function
orf19.6494WHI3Candida albicans SC5314Putative RNA binding protein; induced during infection of murine kidney, compared to growth in vitro; has murine homolog
orf19.5839PDR17Candida albicans SC5314Fungal-specific protein (no human or murine homolog); role in sensitivity to fluconazole, specifically
orf19.6496TRS33Candida albicans SC5314Putative TRAPP complex subunit; constitutive expression independent of MTL or white-opaque status
orf19.6498Candida albicans SC5314Protein of unknown function
orf19.3156Candida albicans SC5314Protein of unknown function; induced by Mnl1 under weak acid stress
orf19.5840Candida albicans SC5314Protein of unknown function
orf19.3273Candida albicans SC5314Protein of unknown function
orf19.3276PWP2Candida albicans SC5314Putative 90S pre-ribosomal component; repressed in core stress response; repressed by prostaglandins; physically interacts with TAP-tagged Nop1; Hap43-induced
Locus IdGene NameOrganismDescription
orf19.3278GSY1Candida albicans SC5314UDP glucose/starch glucosyltransferase; transcript repressed by yeast-hyphal switch, Efg1-regulated; strong oxidative stress induced; colony morphology-related regulation by Ssn6; stationary phase enriched; flow model biofilm induced
orf19.5960NCE102Candida albicans SC5314Non classical protein export protein; localized to plasma membrane; Hap43-induced gene; flow model biofilm induced; Spider biofilm induced
orf19.3281Candida albicans SC5314Protein of unknown function
orf19.3285Candida albicans SC5314Protein of unknown function
orf19.5970Candida albicans SC5314Putative DNA repair helicase; transcriptionally induced by interaction with macrophage; fungal-specific (no human or murine homolog)
orf19.5973PHB2Candida albicans SC5314Prohibitin 2; plasma membrane localized
orf19.5975TRY4Candida albicans SC5314C2H2 transcription factor; fluconazole-repressed; induced in ssr1 mutant; required for yeast cell adherence to silicone substrate; Spider biofilm induced
orf19.2633HGT14Candida albicans SC5314Putative MFS glucose transporter; 20 member C. albicans glucose transporter family; 12 probable membrane-spanning segments; expressed in rich medium with 2% glucose; rat catheter and flow model biofilm induced
orf19.3290Candida albicans SC5314Plasma membrane-localized protein; repressed by nitric oxide; Hap43p-repressed gene
orf19.3291HMT1Candida albicans SC5314Major type I protein arginine methyltransferase (PRMT); involved in asymmetric dimethylation of arginine residues; involved in nuclear export of Npl3p; Spider biofilm repressed
orf19.2637Candida albicans SC5314Protein of unknown function
orf19.2638Candida albicans SC5314Protein of unknown function; Spider biofilm induced
orf19.3295Candida albicans SC5314Protein of unknown function
orf19.3297Candida albicans SC5314Protein of unknown function
orf19.5982RPL18Candida albicans SC5314Predicted ribosomal protein; Plc1p-regulated, Tbf1-activated; repressed upon phagocytosis by murine macrophage; Hap43p-induced; Spider biofilm repressed
orf19.5984Candida albicans SC5314Putative protein of unknown function; homozygous transposon insertion causes decreased colony wrinkling under filamentous growth-inducing conditions, but does not block true hyphal formation in liquid media
orf19.2643RPO26Candida albicans SC5314Putative RNA polymerase subunit; heterozygous null mutant exhibits resistance to parnafungin in the C. albicans fitness test
orf19.6225.1Candida albicans SC5314Protein of unknown function
orf19.6630Candida albicans SC5314Protein of unknown function
orf19.6264.4Candida albicans SC5314Ortholog of S. cerevisiae Rpl39; a component of the 60S ribosomal subunit; Hap43-induced; Spider biofilm repressed
Locus IdGene NameOrganismDescription
orf19.6265.1RPS14BCandida albicans SC5314Putative ribosomal protein; repressed upon phagocytosis by murine macrophage; transcript positively regulated by Tbf1; Spider biofilm repressed
orf19.6286.2RPS27Candida albicans SC5314Putative ribosomal protein; repressed upon phagocytosis by murine macrophage; Spider biofilm repressed
orf19.6313.2MVB12Candida albicans SC5314ESCRT-I complex subunit with a role in multivesicular body (MVB) trafficking; mutant displays growth defect on alkaline medium; Hap43p-repressed gene
orf19.6316.4Candida albicans SC5314Protein of unknown function; Hap43-induced; rat catheter and Spider biofilm induced
orf19.6415.1Candida albicans SC5314Protein of unknown function
orf19.6531.1TOM7Candida albicans SC5314Predicted component of the TOM (translocase of outer membrane) complex involved in protein translocation into mitochondria; flucytosine induced
orf19.6534.2CRN1Candida albicans SC5314Coronin; cortical actin cytoskeletal component; predicted role in regulation of actin patch assembly; rat catheter and Spider biofilm repressed
orf19.6731.1Candida albicans SC5314Protein of unknown function
orf19.6833.2Candida albicans SC5314Protein of unknown function
orf19.6873.1KTI11Candida albicans SC5314Zn-ribbon protein; required for synthesis of diphthamide on translation factor eEF2; involved in modification of wobble nucleosides in tRNAs; rat catheter and Spider biofilm induced
orf19.6882.1Candida albicans SC5314Ribosomal 60S subunit protein; Spider biofilm repressed
orf19.7014Candida albicans SC5314Putative protein of unknown function; transcription is positively regulated by Tbf1p; overlaps orf19.7015
orf19.7070Candida albicans SC5314Protein of unknown function
orf19.1091NOP8Candida albicans SC5314Ortholog of S. cereviiae Nop8; has a role in ribosomal large subunit biogenesis; rat catheter and Spider biofilm induced
orf19.6323HPA2Candida albicans SC5314Protein of unknown function
orf19.3781Candida albicans SC5314Protein of unknown function; Hap43-repressed; Spider biofilm induced
orf19.3787Candida albicans SC5314Protein of unknown function
orf19.6337TLO13Candida albicans SC5314Member of a family of telomere-proximal genes of unknown function; may be spliced in vivo; overlaps orf19.6337.1, which is a region annotated as blocked reading frame
orf19.3791FGR10Candida albicans SC5314Putative asparaginase; lacks ortholog in S. cerevisiae; transposon mutation affects filamentous growth; Spider biofilm induced
orf19.3793Candida albicans SC5314Protein of unknown function; mRNA binds She3; regulated by Nrg1; upregulated in a cyr1 or ras1 mutant
Locus IdGene NameOrganismDescription
orf19.3796DCR1Candida albicans SC5314Putative Dicer RNAse involved in RNA interference, similar to S. cerevisiae Rnt1p but orthologous to S. castellii Dcr1p, which is not conserved in S. cerevisiae
orf19.3798Candida albicans SC5314Protein of unknown function
orf19.6340Candida albicans SC5314Protein of unknown function
orf19.6343FEN1Candida albicans SC5314Putative fatty acid elongase; predicted role in sphingolipid biosynthesis; possibly an essential gene, disruptants not obtained by UAU1 method; Spider and flow model biofilm induced
orf19.3001TEM1Candida albicans SC5314Protein similar to S. cerevisiae Tem1p, which is a GTPase involved in termination of the M phase of the cell cycle; induced under Cdc5p depletion
orf19.3002RPS1Candida albicans SC5314Putative ribosomal protein 10 of the 40S subunit; elicits host antibody response during infection; transcript induced during active growth; Spider biofilm repressed
orf19.3003Candida albicans SC5314Putative lipid-binding protein with a predicted role in calcium-dependent phospholipid-binding
orf19.6348Candida albicans SC5314Predicted cysteine proteinase domain; mutants are viable
orf19.3006GGA2Candida albicans SC5314Protein involved in Golgi trafficking; rat catheter and Spider biofilm repressed
orf19.3009Candida albicans SC5314Protein of unknown function
orf19.6351Candida albicans SC5314Protein of unknown function
orf19.6354Candida albicans SC5314Protein of unknown function
orf19.5842Candida albicans SC5314Protein with predicted siroheme synthase middle domains NAD(P)-binding; Hap43-repressed gene
orf19.5844Candida albicans SC5314Protein of unknown function
orf19.5845RNR3Candida albicans SC5314Putative ribonucleotide reductase large subunit; transcript induced in low iron; rat catheter and Spider biofilm induced
orf19.3160HSP12Candida albicans SC5314Heat-shock protein; induced by osmotic/oxidative/cadmium stress, fluphenazine treatment, low iron, CDR1 and CDR2 overexpression, or ssn6 or ssk1 null mutation; overexpression increases resistance to farnesol and azoles
orf19.3161Candida albicans SC5314Protein of unknown function
orf19.5849CWT1Candida albicans SC5314Zn2Cys6 transcription factor involved in negative regulation of nitrosative stress response; mutant has cell wall defects; transcription increased at stationary phase; has predicted PAS domain; similar to S. cerevisiae Rds2p
orf19.3163Candida albicans SC5314Protein of unknown function
orf19.2509Candida albicans SC5314Protein of unknown function
Locus IdGene NameOrganismDescription
orf19.3167Candida albicans SC5314Heme A:farnesyltransferase; catalyzes the 1st step in conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; Spider biofilm repressed
orf19.5857Candida albicans SC5314Protein of unknown function
orf19.5858EGD2Candida albicans SC5314Nascent polypeptide associated complex protein alpha subunit; soluble protein in hyphae; macrophage/pseudohyphal-induced; protein level decrease in stationary phase cultures; GlcNAc-induced protein; Spider biofilm repressed
orf19.2515Candida albicans SC5314ZZ-type zinc finger protein; rat catheter and Spider biofilm induced
orf19.2516Candida albicans SC5314Protein of unknown function
orf19.2517Candida albicans SC5314Predicted membrane transporter, member of the drug:proton antiporter (12 spanner) (DHA1) family, major facilitator superfamily (MFS)
orf19.3175Candida albicans SC5314Putative ortholog of human electron transfer flavoprotein dehydrogenase (ETF-dH); alkaline repressed; repressed by nitric oxide; virulence-group-correlated expression; Spider biofilm induced
orf19.3176RIM21Candida albicans SC5314Plasma membrane pH-sensor involved in the Rim101 pH response pathway; required for processing and activation of Rim101 and for alkaline pH-induced hyphal growth; Spider biofilm induced
orf19.5862AFP99Candida albicans SC5314Protein related to arginases; downregulated upon adherence to polystyrene; regulated by Gcn2p and Gcn4p
orf19.5864URK1Candida albicans SC5314Protein similar to uridine kinase; repressed by ciclopirox olamine; Spider biofilm induced
orf19.5865Candida albicans SC5314Protein of unknown function
orf19.5867WSC1Candida albicans SC5314Putative cell wall component; transcript upregulated in cyr1 mutant (yeast or hyphae); Spider and flow model biofilm induced
orf19.2524MGE1Candida albicans SC5314Putative mitochondrial matrix cochaperone; macrophage/pseudohyphal-repressed
orf19.2644QCR2Candida albicans SC5314Ubiquinol-cytochrome-c reductase; antigenic; induced by interaction with macrophage; repressed by nitric oxide; in detergent-resistant membrane fraction (possible lipid raft component); levels decrease in stationary phase; Hap43p-repressed
orf19.2646ZCF13Candida albicans SC5314Predicted Zn(II)2Cys6 transcription factor; similar to but not the true ortholog of S. cerevisiae Hap1; mutants display decreased colonization of mouse kidneys
orf19.2649PCL1Candida albicans SC5314Cyclin homolog; transcript induced by filamentous growth; induced by alpha pheromone in SpiderM medium
orf19.5992WOR2Candida albicans SC5314Zn(II)2Cys6 transcription factor; regulator of white-opaque switching; required for maintenance of opaque state; Hap43-induced
orf19.5994RHB1Candida albicans SC5314Putative small G protein from the Ras superfamily involved in cell wall integrity and control of filamentous growth under nitrogen starvation
orf19.5995MCA1Candida albicans SC5314Putative cysteine protease with similarity to S. cerevisiae Mca1p; has a role in apoptotic cell death upon H2O2 treatment; fungal-specific (no human or murine homolog); farnesol-induced
orf19.2653Candida albicans SC5314Protein with a transient receptor potential (TRP) ion channel domain; mutants are viable; rat catheter and Spider biofilm induced; flow model biofilm repressed
Locus IdGene NameOrganismDescription
orf19.5999DYN1Candida albicans SC5314Dynein heavy chain; motor protein that moves to microtubule minus end; required for yeast cell separation, spindle positioning, nuclear migration, hyphal growth; regulated by Mig1, Hap43; flow model and rat catheter biofilm repressed
orf19.5207Candida albicans SC5314Predicted diphthamide biosynthesis protein; Spider biofilm induced
orf19.2663Candida albicans SC5314Protein of unknown function
orf19.2665MSN5Candida albicans SC5314Predicted karyopherin involved in nuclear import and export of proteins; flow model biofilm induced; Spider biofilm induced
orf19.2668RHD2Candida albicans SC5314Predicted ORF in retrotransposon Tca4 with similarity to the Gag region encoding nucleocapsid-like protein; overlaps blocked reading frame orf19.2668.1; yeast-enriched transcript; rat catheter biofilm induced
orf19.5211IDP1Candida albicans SC5314Putative isocitrate dehydrogenase; transcriptionally induced by interaction with macrophage; alkaline induced; Spider biofilm repressed
orf19.5213Candida albicans SC5314Putative protein of unknown function; transcript is upregulated in clinical isolates from HIV+ patients with oral candidiasis
orf19.5215TES15Candida albicans SC5314Putative acyl-CoA thioesterase; Hap43-repressed; Spider biofilm induced
orf19.2670Candida albicans SC5314Protein of unknown function
orf19.2673Candida albicans SC5314Protein of unknown function
orf19.2675Candida albicans SC5314Protein of unknown function
orf19.2677Candida albicans SC5314Putative GPI transamidase component; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.6179Candida albicans SC5314Protein of unknown function
orf19.6181Candida albicans SC5314Protein of unknown function
orf19.6188Candida albicans SC5314Putative adhesin-like protein
orf19.6325.1Candida albicans SC5314Protein of unknown function
orf19.2661TLO34Candida albicans SC5314Non-telomeric member of a family of telomere-proximal genes of unknown function; predicted N-terminus is extended, relative to that of other family members; overlaps orf19.2662
orf19.6599.1Candida albicans SC5314Protein of unknown function
orf19.6601.1YKE2Candida albicans SC5314Possible heterohexameric Gim/prefoldin protein complex subunit; role in folding alpha-tubulin, beta-tubulin, and actin; transcript induced by yeast-to-hypha switch; regulated by Nrg1, Tup1; Spider and flow model biofilm induced
orf19.6834.10TAR1Candida albicans SC5314Ortholog of S. cerevisiae Tar1p; Transcript Antisense to Ribosomal RNA; encoded within the 25S rRNA gene on the opposite strand; induced by Tbf1
Locus IdGene NameOrganismDescription
orf19.6898.1Candida albicans SC5314Protein of unknown function
orf19.7127.1Candida albicans SC5314Putative protein of unknown function, transcript is upregulated in an RHE model of oral candidiasis
orf19.7215.3Candida albicans SC5314Protein of unknown function
orf19.7276.1TLO4Candida albicans SC5314Member of a family of telomere-proximal genes of unknown function; transcript induced in an RHE model of oral candidiasis; Hap43-repressed
orf19.7299.1Candida albicans SC5314Protein of unknown function
orf19.7398.1TSA1BCandida albicans SC5314Putative peroxidase; orf19.7398.1 is contig-truncated fragment of gene identical to TSA1; Tsa1p and Tsa1Bp role under oxidative/reductive stress, hyphal cell wall formation; in hyphal nucleus, cell wall; yeast-form nucleus, cytoplasm
orf19.7399Candida albicans SC5314ORF Predicted by Annotation Working Group; removed from Assembly 21
orf19.7409.1Candida albicans SC5314Protein of unknown function
orf19.7436.1ECM15Candida albicans SC5314Protein of unknown function; predicted role in cell wall organization; Hap43-repressed; caspofungin repressed; Spider biofilm induced; rat catheter biofilm repressed
orf19.7675Candida albicans SC5314Mitochondrial ribosomal protein of the large subunit; Spider biofilm repressed
orf19.7489.3Candida albicans SC5314Protein of unknown function
orf19.7509.1ATP17Candida albicans SC5314Mitochondrial ATPase complex subunit; downregulated by Efg1p; flucytosine induced; caspofungin repressed
orf19.6355Candida albicans SC5314Protein of unknown function
orf19.6356Candida albicans SC5314Protein of unknown function
orf19.5705NAM2Candida albicans SC5314Mitochondrial leucyl-tRNA synthetase
orf19.3021Candida albicans SC5314Putative protein of unknown function; Hap43-repressed gene; Spider biofilm induced
orf19.6366Candida albicans SC5314Protein of unknown function
orf19.6369RIO2Candida albicans SC5314Putative serine kinase with a predicted role in the processing of the 20S pre-rRNA into mature 18S rRNA; null mutants are hypersensitive to caspofungin
orf19.3027Candida albicans SC5314Putative DNA translocase; Spider biofilm repressed
orf19.5710Candida albicans SC5314Nucleoporin component of central core of the nuclear pore complex; mRNA binds She3
Locus IdGene NameOrganismDescription
orf19.5714SAP1Candida albicans SC5314Secreted aspartyl proteinase; acts in utilization of protein as nitrogen source; assessment of virulence role complicated by URA3 effects; regulated by growth phase, alpha-pheromone; produced by opaque cells
orf19.5716SAP4Candida albicans SC5314Secreted aspartyl proteinase; sap4,5,6 mutant defective in protein utilization for nitrogen; virulence role complicated by URA3 effects; expressed during mucosal and systemic infections; N-glycosylated; rat catheter, Spider biofilm induced
orf19.3030Candida albicans SC5314Protein of unknown function
orf19.5718Candida albicans SC5314Protein of unknown function
orf19.6377Candida albicans SC5314Protein of unknown function
orf19.6378TRM9Candida albicans SC5314Putative tRNA methyltransferase; repressed during the mating process
orf19.3037Candida albicans SC5314Putative poly(A)-binding protein; regulated by Gcn4p; induced in response to amino acid starvation (3-AT treatment); protein present in exponential and stationary growth phase yeast cultures
orf19.5724Candida albicans SC5314Protein of unknown function
orf19.6382Candida albicans SC5314Putative MRP/CFTR-subfamily ABC transporter; member of multidrug resistance-associated protein (MRP) subfamily of ABC family; similar to S. cerevisiae Bpt1p
orf19.5727Candida albicans SC5314Protein of unknown function
orf19.5728Candida albicans SC5314Putative cytochrome P450; Spider biofilm induced
orf19.5729FGR17Candida albicans SC5314Putative DNA-binding transcription factor; has zinc cluster DNA-binding motif; lacks an ortholog in S. cerevisiae; transposon mutation affects filamentous growth; Hap43p-repressed gene
orf19.3043Candida albicans SC5314Protein of unknown function
orf19.3182GIS2Candida albicans SC5314Translational activator for mRNAs with internal ribosome entry sites; induced in high iron; repressed by yeast-hypha switch; null exhibits sensitivity to sorbitol, 5-fluorocytosine, and cold temperatures; Spider biofilm repressed
orf19.2527Candida albicans SC5314Putative protein of unknown function; Hap43-induced; required for normal biofilm growth; F-12/CO2 early biofilm induced
orf19.3185Candida albicans SC5314Protein of unknown function
orf19.3188TAC1Candida albicans SC5314Zn(2)-Cys(6) transcriptional activator of drug-responsive genes (CDR1 and CDR2); binds DRE element; gene in zinc cluster region near MTL locus; resequencing indicates that TAC1 spans orf19.3188 and orf19.3189; Spider biofilm induced
orf19.5871SNF5Candida albicans SC5314SWI/SNF chromatin remodeling complex subunit involved in transcriptional regulation; mutants have defects in silicone adherence, biofilm formation, hyphal morphogenesis, cell wall defects; increased cell aggregation during yeast form growth
orf19.5873POL1Candida albicans SC5314Putative DNA directed DNA polymerase alpha; RNA abundance regulated by cell cycle, tyrosol and cell density; rat catheter biofilm induced
orf19.2531CSP37Candida albicans SC5314Hyphal cell wall protein; role in progression of mouse systemic infection; predicted P-loop, divalent cation binding, N-glycosylation sites; expressed in yeast and hyphae; hyphal downregulated; stationary-phase