External Resources |
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Candida Genomes |
Candida albicans strain SC5314 genome sequence
Assembly 19: The C. albicans strain SC5314 genome sequence and diploid contig-level assembly by the Stanford Genome Technology Center was published in Jones et al. (2004). View the A19 paper and download the A19
supplementary information and sequence files or the original A19 sequence trace files.
(The construction of the sequencing library and sequencing methods are described in Tzung et al. (2001).) Assembly 21: The haploid chromosomal-level
Assembly 21 reference sequence is described in van het Hoog et al. (2007).
Candida albicans strain WO-1 genome project The genome of
C. albicans strain WO-1, sequenced at the Broad Institute as part of the Fungal Genome Initiative
(FGI).
Candida albicans strain 1161 genome project Home page for C. albicans strain
1161 sequencing at the Sanger Institute.
Candida dubliniensis genome project Home page for C. dubliniensis
sequencing at the Sanger Institute.
Candida glabrata genome project A sequencing project of the Genolevures Consortium.
Candida guilliermondii genome project The C.
guilliermondii genome, sequenced at the Broad Institute as part of the Fungal Genome Initiative
(FGI).
Candida lusitaniae genome project The C. lusitaniae
genome, sequenced at the Broad Institute as part of the Fungal Genome Initiative (FGI).
Candida parapsilosis genome project Home page for C. parapsilosis
sequencing at the Sanger Institute.
Candida tropicalis genome project The C. tropicalis
genome, sequenced at the Broad Institute as part of the Fungal Genome Initiative (FGI).
Candida Genome Comparisons Supplementary data from Butler et al. (2009) for eight
Candida genomes. Includes genome characteristics (size, telomeres, centromeres, retrotransposons and repeats, CUG usage, SNPs, etc.), phylogeny, gene families and
function (pathogenesis-associated gene families, cell wall, stress response, mating and meiosis, etc.), cross-species comparisons (alignments, synteny). Data are available
for download as supplementary material associated with the paper, and from the Broad Institute website.
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Candida Resources |
Candida albicans pages at the NRC-BRI Genomic information and tools from the
Biotechnology Research Institute (National Research Council, Canada). View Assembly 21 of the C. albicans genome sequence and search the annotation of Assembly 19
generated by the Annotation Working Group, described in the publication by Braun et al., 2005.
CandidaDB Genomic database for C. albicans and related species, part of the
Galar Fungail Consortium project. The previous version of CandidaDB is described in the publication by d'Enfert et al., 2005.
Institute for Candida experimentation at the University of Minnesota Database containing physical
map data and other molecular biology information.
Multi Locus Sequence Typing (MLST)
Multi Locus Sequence Typing (MLST) schemes and isolate databases for C. albicans, C. glabrata, C. krusei, and C. tropicalis are available from PubMLST.org
The website offers tools for strain typing and epidemiology, as well as extensive, manually curated isolate databases. Sequence data is accepted on the basis of individual sanger sequences as well as whole genome level.
The old databases (not curated anymore) are still available. All data have been migrated to PubMLST.org in 2016.
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Analysis Tools |
PathoYeastract PathoYeastract (Pathogenic Yeast Search for Transcriptional Regulators And Consensus Tracking) is a curated repository of all known regulatory associations between transcription factors (TF) and target genes in pathogenic Candida species, based on hundreds of bibliographic references. Currently, it includes C. albicans and C. glabrata, but addition of six more Candida species is under way. Described in Monteiro et al., 2017.
FungiFun2 Online resource that assigns functional annotations to lists of fungal genes or proteins
based on different classification methods (Gene Ontology, Functional Catalog, KEGG) and performs an enrichment analysis to identify significantly enriched pathways or
processes, described in Priebe et al., 2015.
Homann et al. Phenotype Viewer Software and instructions to view phenotype image data reported in Homann et al., 2009.
C. albicans Multilocus Sequence Typing (MLST) Tools for strain typing and epidemiology, hosted at
Imperial College London, and described in M.-E. Bougnoux et al.
(2003).
Bioinformatics and Sequence Analysis Tools Tools on the web
site of the Center for Biological Sequence Analysis at the Technical University of Denmark. Gene-finding, RNA splicing, protein modification, protein sorting predictions,
and more.
Regulatory Sequence Analysis (RSA) Tools Tools for analysis of nucleotide sequence patterns in Assembly
19.
Multi-genome Analysis of Positions and Patterns of Elements of Regulation (MAPPER) Tools for prediction of
transcription factor binding sites.
Fungal Genomes BLAST at SGD BLAST search for sequence similarity within fungal genomes,
provided by the Saccharomyces Genome Database.
Microbial Genomes BLAST at NCBI BLAST search for sequence similarity within microbial
genomes.
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Research Tools |
Candida strains at the Fungal Genetics Stock Center
Request strains from several different mutant collections
Developmental Studies Hybridoma Bank Collection of hybridomas and their antibodies that in the future will
include DSHB-Microbe, a collection of antibodies against C. albicans antigens and those of other microbial pathogens.
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Medical Mycology Resources |
Candidiasis Information at Medline Plus Medical information about
candidiasis.
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Other Fungal Information |
Saccharomyces Genome Database Genome, gene, and protein information for the model yeast Saccharomyces
cerevisiae.
Debaryomyces hansenii genome project A sequencing project of the Genolevures Consortium.
Lodderomyces elongisporus Database The
Lodderomyces elongisporus genome, sequenced at the Broad Institute as part of the Fungal Genome Initiative
(FGI).
Cryptococcus neoformans genome project Home page of the genome
sequencing effort for the fungal pathogen C. neoformans at the Stanford Genome Technology Center.
Aspergillus Genome Database Genome, gene, and protein information for Aspergillus
nidulans.
The Aspergillus Website Database with genomic information
on the fungal pathogen Aspergillus fumigatus and clinical information on aspergillosis.
Aspergillus nidulans Database Home page for the A. nidulans genome
project at the Broad Institute, part of the Fungal Genome Initiative (FGI).
Ashbya Genome Database Genome information for Ashbya gossypii, a hemiascomycete plant pathogen with a
small genome that exhibits remarkable synteny with the S. cerevisiae genome.
Magnaporthe grisea Database Home page for the M. grisea genome
project at the Broad Institute, part of the Fungal Genome Initiative (FGI).
Schizosaccharomyces pombe genome project Complete sequence and annotation of the S.
pombe ("fission yeast") genome at the Sanger Institute.
Neurospora crassa Database Home page for the N. crassa genome project
at the Broad Institute, part of the Fungal Genome Initiative (FGI).
Fungal Genetics Stock Center General fungal information, focusing on filamentous fungi; has links to many fungal
genome projects.
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Other Resources |
GenBank Sequence repository at the NCBI,
Bethesda, Maryland, USA.
EMBL Sequence repository at the EBI, Hinxton Hall, Cambridge,
UK.
DDBJ Sequence repository at Mishima, Japan.
GenePalette Software application, freely available to academic users, for visualizing annotated
features and other sequence elements in GenBank sequences.
PredictProtein Program for protein structure prediction, from the Protein Design Group at EMBL.
Gene Ontology Gene Ontology (GO) Consortium home page.
KEGG Metabolic reactions and pathways from Kyoto University, Kyoto, Japan.
Nucleic Acids Research Database Issues Articles about genomic and biological databases. Papers about CGD were published in the 2010, 2007, and 2005 Database Issues.
Go to NAR Database Issue for:
2010| 2009| 2008| 2007| 2006| 2005| 2004| 2003| 2002| 2001| 2000| 1999| 1998
CGD Papers |
Skrzypek MS, Arnaud MB, Costanzo MC, Inglis DO, Shah P, Binkley G, Miyasato SR, Sherlock G. New tools at the Candida Genome Database: biochemical pathways and full-text literature search. Nucleic Acids Res. 2010 Jan;38(Database issue):D428-32. Available here.
Arnaud MB, Costanzo MC, Shah P, Skrzypek MS, Sherlock G. Gene Ontology and the
annotation of pathogen genomes: the case of Candida albicans. Trends Microbiol. 2009 Jul 3. Available here.
Butler G, Rasmussen MD, Lin MF, Santos MA, Sakthikumar S, Munro CA, Rheinbay E, Grabherr M, Forche A, Reedy JL, Agrafioti I, Arnaud MB, Bates S, Brown AJ,
Brunke S, Costanzo MC, Fitzpatrick DA, de Groot PW, Harris D, Hoyer LL, Hube B, Klis FM, Kodira C, Lennard N, Logue ME, Martin R, Neiman AM, Nikolaou E, Quail MA, Quinn J,
Santos MC, Schmitzberger FF, Sherlock G, Shah P, Silverstein KA, Skrzypek MS, Soll D, Staggs R, Stansfield I, Stumpf MP, Sudbery PE, Srikantha T, Zeng Q, Berman J,
Berriman M, Heitman J, Gow NA, Lorenz MC, Birren BW, Kellis M, Cuomo CA. Evolution of pathogenicity
and sexual reproduction in eight Candida genomes. Nature 459(7247):657-62. Available
here.
Arnaud MB, Costanzo MC, Skrzypek MS, Shah P, Binkley G, Lane C, Miyasato SR, Sherlock G. Sequence resources at the Candida Genome Database. Nucleic Acids Res. 2007 Jan; 35(Database
issue):D452-6. Available here.
Costanzo MC, Arnaud MB, Skrzypek MS, Binkley G, Lane C, Miyasato SR, Sherlock G. The
Candida Genome Database: Facilitating research on Candida albicans molecular biology. FEMS Yeast Res. 2006 Aug;6(5):671-84. Available on request.
Arnaud MB, Costanzo MC, Skrzypek MS, Binkley G, Lane C, Miyasato SR, Sherlock G. The
Candida Genome Database (CGD), a community resource for Candida albicans gene and protein information. Nucleic Acids Res. 2005 Jan
1;33(Database issue):D358-63. Available here.
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